CN105770969A - Absorbable starch styptic powder, preparation method and applications thereof - Google Patents
Absorbable starch styptic powder, preparation method and applications thereof Download PDFInfo
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- CN105770969A CN105770969A CN201410807309.1A CN201410807309A CN105770969A CN 105770969 A CN105770969 A CN 105770969A CN 201410807309 A CN201410807309 A CN 201410807309A CN 105770969 A CN105770969 A CN 105770969A
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Abstract
The invention discloses an absorbable starch styptic powder, and a preparation method thereof. The absorbable starch styptic powder is prepared by the following steps: taking plant origin starch and hydroxyethyl starch as the raw materials, emulsifying and dispersing the starches in span 80, tween 80, and plant oil at a temperature of 45 to 70 DEG C under a pH value of 9 to 10, adding sodium trimetaphosphate to carry out crosslinking, using ethyl acetate to perform extraction and liquid separation, washing the solid by anhydrous ethanol, drying the solid in a baking oven, and performing sterilization to obtain the styptic powder. The styptic powder has a good biocompatibility, can be directly applied to the common bleeding parts, deep bleeding parts, and bleeding parts that are hard to reach through surgery operation, and is simple and convenient to use. Starches are the raw materials of the styptic powder, thus the styptic powder is nontoxic and nonirritant, moreover, the sources of raw materials are wide, the cost is low, the technology is simple and feasible, and thus the styptic powder has a wide clinical application prospect.
Description
Technical field
The invention belongs to biological medicine Material Field, be specifically related to a kind of absorbability starch hemostatic powder and preparation method thereof.
Background technology
War wound, emergency care of trauma and surgical operation all can be formed hemorrhage, this problem needs solution badly, normal human is respectively provided with hemostatic function, slowly a small amount of hemorrhage self function can be relied on to stop blooding, but, the disguised oozing phenomenon body broken for hemorrhage, the internal organs of human body artery in various sudden accidents etc. can not stop blooding voluntarily, can not only lean on common tourniquet bandage hemostasis by compression, if patient's severe loss of blood, it is possible to shock, even entail dangers to life and health can be caused.Effective Hemostasis conventional at present is the resorbable material hemostasis of employing biocompatibility, provides a kind of safe and effective in surgical operation, first aid etc. are stopped blooding, and easy to use, hemostatic material with low cost is particularly important.
At present, the hemostatic material used clinically mainly has Fibrin Glue, collagen protein, gelfoam and cellulose hemostatic material, these materials all achieve good effect in zoopery and clinical practice, but also all come with some shortcomings: its raw material sources of collagen are in animal tissue, it it is foreign protein, rejection easily occurs, there is potential sensitization；Gelatin infiltration rate is slow, general more than 4 weeks, can increase the infection risk of wound；Cellulose family, human body lacks makes its enzyme degraded, and degradation time is long, it is possible to can bring the side effect such as infection to patient.
Starch is plant polysaccharide, its good biocompatibility, nontoxic, non-stimulated, not easily cause the anaphylaxis of body, monosaccharide can be degraded to by the amylase in body fluid in vivo, degradation in vivo absorbs.Carboxymethyl starch (CMS) is a kind of water solublity modified starch, has good biocompatibility, has stronger water absorption and dilatancy, can comparatively fast steep and rise in cold water, and after water suction grain expansion and insoluble.Starch hemostatic material representative at present is Arista styptic powder produced in USA, although its haemostatic effect is good, but it adopts epichlorohydrin cross-linked, there is genotoxic potential, and expensive, limits its application.
Summary of the invention
In order to solve the deficiencies in the prior art, the present invention provides a kind of absorbability starch hemostatic powder and its preparation method and application, this styptic powder has good biocompatibility, safety non-toxic, technique simple possible, can be done directly on generally hemorrhage, Hemorrhage in Deep and the unapproachable position of operation technique hemorrhage, easy to use, and the preparation method providing this styptic powder.
A kind of preparation method of absorbability starch hemostatic powder, including step: plant ative starch is first microwaved, and wash dry, then again by blended soluble in water to the starch after microwaved and carboxymethyl starch, disperse through emulsifier, cross-linking agents, extractant extracting, washing, dries, sterilizing, thus obtaining the product absorbability starch hemostatic powder.
Further, described step microwaved for described plant ative starch is specifically included: weigh a certain amount of ative starch and be dissolved in distilled water, make serosity, be then placed in microwave oven, carry out microwave treatment, microwave treatment power is 700-800W, microwave treatment time is 5-8min, and microwave treatment temperature is 80-90 DEG C, cooled sucking filtration, absolute ethanol washing, dries the starch after obtaining microwave treatment.
Further, described by blended soluble in water to the starch after microwaved and carboxymethyl starch, disperse through emulsifier, cross-linking agents, extractant extracting, washing, drying, the step of sterilizing, thus obtaining the product absorbability starch hemostatic powder specifically includes: produce mixing starch suspension: by weight for (0.5-2): (1-5), by starch in step 1) and carboxymethyl starch, is dissolved in the distilled water of 20-40 times, stir, regulate pH to 9-10 with sodium hydroxide；
Produce mixing starch emulsion: weigh a certain amount of Span 80 for 1:1 by weight and Tween 80 makes blended emulsifier, mix with the vegetable oil dispersion of certain volume again, 10-30min is stirred under 45-70 DEG C of water bath with thermostatic control, make emulsifying dispersant, then the mixing starch suspension produced is added wherein, stir 10-30min, the envelope-bulk to weight ratio of vegetable oil and mixing starch is 15-100:1, the weight ratio of ml/g, blended emulsifier and mixing starch is 0.5-2.5:1, g/g；
Cross-linking reaction: weigh a certain amount of sodium trimetaphosphate and be dissolved in distilled water, is subsequently adding in step 3) in the mixing starch emulsion of preparation, stirring reaction 2-8h, and wherein, the weight ratio of sodium trimetaphosphate and mixing starch is 0.01-0.2:1, g/g；
Extracting extracts: by the mixed solution stratification through cross-linking reaction, abandon supernatant, the ethyl acetate solution of 5-10 times of volume is added in lower floor's milky white liquid, after stirring, stratification, takes off layer milky white liquid and adds the absolute ethanol washing of 2-5 times of volume, stratification after stirring, abandoning supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle；
Prepare styptic powder: be dissolved in the distilled water of 3-5 times of volume by prepared powder, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
Preferably, the weight ratio of described starch and carboxymethyl starch is 1:2.
Preferably, described plant amylum includes potato starch, corn starch, sweet potato starch, one or more in wheaten starch.
Preferably, described vegetable oil is bean plant oil.
Correspondingly, present invention also offers a kind of absorbability starch hemostatic powder adopting said method to prepare.
Product of the present invention adopts good biocompatibility, the starch of safety non-toxic is that raw material prepares, bleeding part can be directly acted on, absorb rapidly the moisture in blood, reduce blood flowing speed, erythrocyte and PC increase, blood self-solidifying, play the effect of hemostasis by compression after material imbibition simultaneously.
Product preparation process of the present invention is simple, with low cost, can be used for various operating generally hemorrhage, Hemorrhage in Deep and the unapproachable position of operation technique is hemorrhage, easy to use.
Specific embodiment
In order to be more fully understood that technical scheme, it is described in further detail by embodiment in detail below, but protection scope of the present invention is not limited only to following embodiment.
Embodiment 1:
1) weigh 5g potato starch and be dissolved in distilled water, make serosity, be then placed in microwave oven, carry out microwave treatment, microwave treatment power is 800W, and microwave treatment time is 5min, and microwave treatment temperature is 85 DEG C, cooled sucking filtration, absolute ethanol washing, the dry starch obtaining microwave treatment；
2) starch in step 1) is mixed with 10g carboxymethyl starch it is dissolved in 300ml distilled water, regulate pH to 9-10 with sodium hydroxide after stirring, prepare mixing starch suspension；
3) weigh 4g Span 80 respectively and Tween 80 is dissolved in the vegetable oil of 800ml, 50 ± 5 DEG C of stirring 20min, prepare mixing and emulsifying dispersant, be subsequently adding in mixing starch suspension and stir 20min, prepare mixing starch emulsion；
4) weigh 0.2g sodium trimetaphosphate and be dissolved in distilled water, be subsequently adding in mixing starch emulsion, stirring crosslinking 2h, prepare crosslinked fluid；
5) by crosslinked fluid stratification, abandon supernatant, after in lower floor's milky white liquid, the ethyl acetate of 5 times of volumes of addition stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 3 times of volumes, stratification after stirring, abandon supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle；
6) prepared solid particle is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
Embodiment 2:
1) weigh 10g potato starch and be dissolved in distilled water, make serosity, be then placed in microwave oven, carry out microwave treatment, microwave treatment power is 750W, and microwave treatment time is 5min, and microwave treatment temperature is 85 DEG C, cooled sucking filtration, absolute ethanol washing, the dry starch obtaining microwave treatment；
2) starch in step 1) is mixed with 10g carboxymethyl starch it is dissolved in 300ml distilled water, regulate pH to 9-10 with sodium hydroxide after stirring, prepare mixing starch suspension；
3) weigh 7g Span 80 respectively and Tween 80 is dissolved in the vegetable oil of 800ml, 50 ± 5 DEG C of stirring 20min, prepare mixing and emulsifying dispersant, be subsequently adding in mixing starch suspension and stir 20min, prepare mixing starch emulsion；
4) weigh 0.6g sodium trimetaphosphate and be dissolved in distilled water, be subsequently adding in mixing starch emulsion, stirring crosslinking 6h, prepare crosslinked fluid；
5) by crosslinked fluid stratification, abandon supernatant, after in lower floor's milky white liquid, the ethyl acetate of 5 times of volumes of addition stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 3 times of volumes, stratification after stirring, abandon supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle；
6) prepared solid particle is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
Embodiment 3:
1) weigh 5g potato starch and be dissolved in distilled water, make serosity, be then placed in microwave oven, carry out microwave treatment, microwave treatment power is 750W, and microwave treatment time is 8min, and microwave treatment temperature is 90 DEG C, cooled sucking filtration, absolute ethanol washing, the dry starch obtaining microwave treatment；
2) starch in step 1) is mixed with 10g carboxymethyl starch it is dissolved in 300ml distilled water, regulate pH to 9-10 with sodium hydroxide after stirring, prepare mixing starch suspension；
3) weigh 4g Span 80 respectively and Tween 80 is dissolved in the vegetable oil of 800ml, 50 ± 5 DEG C of stirring 20min, prepare mixing and emulsifying dispersant, be subsequently adding in mixing starch suspension and stir 20min, prepare mixing starch emulsion；
4) weigh 0.2g sodium trimetaphosphate and be dissolved in distilled water, be subsequently adding in mixing starch emulsion, stirring crosslinking 3h, prepare crosslinked fluid；
5) by crosslinked fluid stratification, abandon supernatant, after in lower floor's milky white liquid, the ethyl acetate of 5 times of volumes of addition stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 3 times of volumes, stratification after stirring, abandon supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle；
6) prepared solid particle is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
Embodiment 4:
1) weigh 10g potato starch and be dissolved in distilled water, make serosity, be then placed in microwave oven, carry out microwave treatment, microwave treatment power is 700W, and microwave treatment time is 7min, and microwave treatment temperature is 90 DEG C, cooled sucking filtration, absolute ethanol washing, the dry starch obtaining microwave treatment；
2) starch in step 1) is mixed with 1g carboxymethyl starch it is dissolved in 300ml distilled water, regulate pH to 9-10 with sodium hydroxide after stirring, prepare mixing starch suspension；
3) weigh 5g Span 80 respectively and Tween 80 is dissolved in the vegetable oil of 800ml, 50 ± 5 DEG C of stirring 15min, prepare mixing and emulsifying dispersant, be subsequently adding in mixing starch suspension and stir 20min, prepare mixing starch emulsion；
4) weigh 0.8g sodium trimetaphosphate and be dissolved in distilled water, be subsequently adding in mixing starch emulsion, stirring crosslinking 8h, prepare crosslinked fluid；
5) by crosslinked fluid stratification, abandon supernatant, after in lower floor's milky white liquid, the ethyl acetate of 5 times of volumes of addition stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 3 times of volumes, stratification after stirring, abandon supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle；
6) prepared solid particle is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
Embodiment 5:
1) weigh 5g potato starch and be dissolved in distilled water, make serosity, be then placed in microwave oven, carry out microwave treatment, microwave treatment power is 800W, and microwave treatment time is 5min, and microwave treatment temperature is 85 DEG C, cooled sucking filtration, absolute ethanol washing, the dry starch obtaining microwave treatment；
2) starch in step 1) is mixed with 10g carboxymethyl starch it is dissolved in 450ml distilled water, regulate pH to 9-10 with sodium hydroxide after stirring, prepare mixing starch suspension；
3) weigh 4g Span 80 respectively and Tween 80 is dissolved in the vegetable oil of 800ml, 60 ± 5 DEG C of stirring 15min, prepare mixing and emulsifying dispersant, be subsequently adding in mixing starch suspension and stir 20min, prepare mixing starch emulsion；
4) weigh 0.2g sodium trimetaphosphate and be dissolved in distilled water, be subsequently adding in mixing starch emulsion, stirring crosslinking 3h, prepare crosslinked fluid；
5) by crosslinked fluid stratification, abandon supernatant, after in lower floor's milky white liquid, the ethyl acetate of 5 times of volumes of addition stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 3 times of volumes, stratification after stirring, abandon supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle；
6) prepared solid particle is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
Embodiment 6:
1) weigh 5g sweet potato starch and be dissolved in distilled water, make serosity, be then placed in microwave oven, carry out microwave treatment, microwave treatment power is 800W, and microwave treatment time is 5min, and microwave treatment temperature is 90 DEG C, cooled sucking filtration, absolute ethanol washing, the dry starch obtaining microwave treatment；
2) starch in step 1) is mixed with 10g carboxymethyl starch it is dissolved in 450ml distilled water, regulate pH to 9-10 with sodium hydroxide after stirring, prepare mixing starch suspension；
3) weigh 4g Span 80 respectively and Tween 80 is dissolved in the vegetable oil of 800ml, 50 ± 5 DEG C of stirring 15min, prepare mixing and emulsifying dispersant, be subsequently adding in mixing starch suspension and stir 20min, prepare mixing starch emulsion；
4) weigh 0.2g sodium trimetaphosphate and be dissolved in distilled water, be subsequently adding in mixing starch emulsion, stirring crosslinking 7h, prepare crosslinked fluid；
5) by crosslinked fluid stratification, abandon supernatant, after in lower floor's milky white liquid, the ethyl acetate of 8 times of volumes of addition stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 4 times of volumes, stratification after stirring, abandon supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle；
6) prepared solid particle is dissolved in the distilled water of 5 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
Claims (7)
1. the preparation method of an absorbability starch hemostatic powder, it is characterized in that, plant ative starch is first microwaved, and wash dry, then again by blended soluble in water with carboxymethyl starch for the starch after microwaved, disperse through emulsifier, cross-linking agents, extractant extracting, washing, dry, sterilizing, thus obtaining the product absorbability starch hemostatic powder.
2. the preparation method of absorbability starch hemostatic powder as claimed in claim 1, it is characterized in that, described by step microwaved for plant ative starch particularly as follows: weigh a certain amount of ative starch and be dissolved in distilled water, make serosity, then it is placed in microwave oven, carrying out microwave treatment, microwave treatment power is 700-800W, and microwave treatment time is 5-8min, microwave treatment temperature is 80-90 DEG C, cooled sucking filtration, absolute ethanol washing, dry the starch after obtaining microwave treatment.
3. the preparation method of absorbability starch hemostatic powder as claimed in claim 2, it is characterized in that, described by blended soluble in water to the starch after microwaved and carboxymethyl starch, disperse through emulsifier, cross-linking agents, extractant extracting, washing, drying, the step of sterilizing, thus obtaining the product absorbability starch hemostatic powder specifically includes:
Prepare mixing starch suspension: by weight for (0.5-2): prepared starch is mixed by (1-5) with carboxymethyl starch, adds in the distilled water of 20-40 times, after stirring, regulates pH9-10 with sodium hydroxide；
Produce mixing starch emulsion: by weight 1:1 weighs a certain amount of Span 80, Tween 80 makes blended emulsifier, mix with the vegetable oil of certain volume again, 45-70 DEG C of water bath with thermostatic control stirring 10-30min stirs, again emulsion is joined in the above-mentioned mixing starch suspension produced, stir 10-30min；The envelope-bulk to weight ratio of vegetable oil and mixing starch is 15-100:1, ml/g, and the weight ratio of blended emulsifier and mixing starch is 0.5-2.5:1, g/g；
Cross-linking reaction: weigh a certain amount of sodium trimetaphosphate and be dissolved in distilled water, is then added in above-mentioned mixing starch emulsion, and the mass ratio stirring 2-8h, sodium trimetaphosphate and mixing starch is 0.01-0.2:1, g/g；
Extracting extracts: by the above-mentioned product stratification through cross-linking reaction, abandon supernatant, the ethyl acetate of 5-10 times of volume is added in lower floor's milky white liquid, it is sufficiently stirred for rear stratification, take off a layer milky white liquid, the absolute ethyl alcohol and stirring adding 2-5 times is cleaned, and then vacuum filtration is to moisture pump, obtains pressed powder；
Prepare styptic powder: be dissolved in the distilled water of 3-5 times of volume by powder obtained above, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
4. the preparation method of absorbability starch hemostatic powder as described in any one in claims 1 to 3, it is characterised in that the weight ratio of described starch and carboxymethyl starch is 1:2.
5. the preparation method of absorbability starch hemostatic powder as described in any one in claims 1 to 3, it is characterised in that described plant ative starch is potato starch, corn starch, sweet potato starch, one or more in wheaten starch.
6. the absorbability starch hemostatic powder that the method as described in claim 1 to 5 prepares.
7. the hemostasis that the application of absorbability starch hemostatic powder as claimed in claim 6, it is characterised in that being applied to various traumatic hemorrhage, surgical operation wound surface is hemorrhage, oozing of blood, Hemorrhage in Deep and the unapproachable position of operation technique are hemorrhage etc..
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108815566A (en) * | 2018-09-20 | 2018-11-16 | 黄旭东 | A kind of preparation method of porous hemostatic starch |
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| CN102406956A (en) * | 2011-03-09 | 2012-04-11 | 天津爱勒易医药材料有限公司 | Starch hemostatic microsphere and preparation method thereof |
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Patent Citations (5)
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| CN101121041A (en) * | 2007-08-09 | 2008-02-13 | 美国淀粉医疗公司 | Denaturated starch absorbable hemostatic material and preparation method thereof |
| EP2233157A1 (en) * | 2007-12-11 | 2010-09-29 | Xin Ji | A biocompatible denatured starch sponge material |
| CN102406956A (en) * | 2011-03-09 | 2012-04-11 | 天津爱勒易医药材料有限公司 | Starch hemostatic microsphere and preparation method thereof |
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| CN108815566A (en) * | 2018-09-20 | 2018-11-16 | 黄旭东 | A kind of preparation method of porous hemostatic starch |
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Application publication date: 20160720 |