CN105251036A - Medical hemostatic material and preparation method thereof - Google Patents
Medical hemostatic material and preparation method thereof Download PDFInfo
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- CN105251036A CN105251036A CN201510639513.1A CN201510639513A CN105251036A CN 105251036 A CN105251036 A CN 105251036A CN 201510639513 A CN201510639513 A CN 201510639513A CN 105251036 A CN105251036 A CN 105251036A
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- hemostatic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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Abstract
The invention particularly relates to a medical hemostatic material and a preparation method thereof, and belongs to the technical field of medical materials. The medical hemostatic material is prepared from a set of mixed materials and non-woven fabrics, wherein the mixed materials comprise, by mass, 60-75 parts of chitosan fiber, 6-15 parts of keratin, 10-25 parts of sodium carboxymethylcellulose and 5-10 parts of polyvinyl alcohol. The medical hemostatic material has the advantages of being fast in hemostasis, excellent in mechanical property, good in biocompatibility and the like.
Description
Technical field
The invention belongs to medical material tech field, be specifically related to a kind of hemostatic material in medical use and preparation method thereof.
Background technology
Usually, in the normal situation of blood of human body self coagulation function, general tissue injury can self-regeneration, and the hemorrhage or venous hemorrhage of epidermis can self-solidifying.But, when arterial hemorrhage, hemorrhage compared with large vein, more serious tissue injury or most surgical procedures, blood cannot reach the function of self-protection in time from coalescence, as taken measures not in time, will cause serious hemorrhage, excessive often threat to life of losing blood.Especially, afield, in the various situation such as field burst accident, earthquake class natural disaster, surgical operation, use hemostatic material fast and effectively particularly important.
In recent years, develop increasing hemostatic material both at home and abroad, existing hemostasia products is mainly divided into two large classes according to hemostatic mechanism, one class is based on the normal clotting mechanism of blood, as gel sthptic sponge product, dry haemproteins product etc., another kind of, be the clotting mechanism not relying on normal blood, the hemostasia products that the material as being representative with chitosan and molecular sieve is made.The range of application of a rear series products is wider, and particularly when the wounded has blood coagulation disorders or use anticoagulant, effect is more more superior.
Usually need to possess following characteristic as excellent hemostatic material in medical use: 1) there is biocompatibility, and to organism avirulence; 2) infection of wound can not be increased, can not can't bring out the reaction of inflammation by contaminated wound; 3) bleeding stopping period is short, haemostatic effect good; 4) mechanical property reaches the premium properties of hemostatic material in medical use; 5) good with the adhesiveness of tissue, good with the anastomose property in wound, site, wound surface place; 6) answer no antigen, degraded and absorbed in vivo can select degradable absorbing material or Nondegradable material according to different hemostasis objects; 7) a large amount of heats is not produced while stopping blooding, to prevent tissue, neural burning; 8) manufacturing cost is as far as possible cheap etc.
In prior art, study the hemostatic material obtaining many types both at home and abroad and developed many hemostasia products, but its mechanical property, anthemorrhagic speed, also do not reach very desirable haemostatic effect with the attaching performance of the tissue of bleeding site or the combination property such as anastomose property, absorbent, and function singleness, all more or less there is such or such deficiency or defect.
Summary of the invention
The object of the invention is to provide a kind of hemostatic material in medical use and preparation method thereof to solve the deficiencies in the prior art, this hemostatic material in medical use has the advantages such as hemostasis is fast, excellent in mechanical performance, good biocompatibility.
The technical solution used in the present invention is as follows:
A kind of hemostatic material in medical use, prepared by one group of composite material and non-woven fabrics and obtain, wherein one group of composite material comprises the following raw material according to mass fraction meter: chitin fiber 60-75 part, k eratin 6-15 parts, sodium carboxymethyl cellulose 10-25 part, polyvinyl alcohol 5-10 part.
Above-described a kind of hemostatic material in medical use, wherein one group of composite material comprises the following raw material according to mass fraction meter: chitin fiber 68 parts, Keratin 10 part, sodium carboxymethyl cellulose 17 parts, polyvinyl alcohol 6 parts.
The preparation method of above-described a kind of hemostatic material in medical use, comprises the steps:
(1) each raw material mix homogeneously in one group of composite material is added to the water, and ultrasonic disperse 1h, obtain dispersion liquid, ultrasonic power is 300W;
(2) non-woven fabrics is impregnated in above-mentioned dispersion liquid, concussion process 12h;
(3) re-use dehydrated alcohol and carry out washing 3 times to the non-woven fabrics after dipping, vacuum lyophilization 24h at-10 DEG C, obtains described hemostatic material in medical use.
Further, in described step (1), the quality of mix homogeneously material and the volume ratio of water are 1mg:1mL.
Further, in described step (2), the surface area of non-woven fabrics and the volume ratio of dispersion liquid are 1cm
2: 2mL.
Beneficial effect of the present invention is: the hemostatic material in medical use that the present invention obtains has the advantages such as hemostasis is fast, excellent in mechanical performance, good biocompatibility, can meet the hemostasis demand of various occasion.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but should not be construed as limitation of the present invention.The raw material used in the present invention unless otherwise noted, all by commercial acquisition.
Embodiment 1
A kind of hemostatic material in medical use, is prepared by one group of composite material and non-woven fabrics and is obtained, and wherein one group of composite material comprises the following raw material according to mass fraction meter: chitin fiber 60 parts, k eratin 6 part, sodium carboxymethyl cellulose 10 parts, polyvinyl alcohol 5 parts.
The preparation method of above-described hemostatic material in medical use, comprises the steps:
(1) each raw material mix homogeneously in one group of composite material is added to the water, and ultrasonic disperse 1h, obtain dispersion liquid, ultrasonic power is 300W, and the quality of mix homogeneously material and the volume ratio of water are 0.8mg:1mL;
(2) be impregnated into by non-woven fabrics in above-mentioned dispersion liquid, concussion process 12h, the surface area of non-woven fabrics and the volume ratio of dispersion liquid are 1cm
2: 1mL;
(3) re-use dehydrated alcohol and carry out washing 3 times to the non-woven fabrics after dipping, vacuum lyophilization 24h at-10 DEG C, obtains described hemostatic material in medical use.
Embodiment 2
A kind of hemostatic material in medical use, is prepared by one group of composite material and non-woven fabrics and is obtained, and wherein one group of composite material comprises the following raw material according to mass fraction meter: chitin fiber 64 parts, CK8 part, sodium carboxymethyl cellulose 13 parts, polyvinyl alcohol 6 parts.
The preparation method of above-described hemostatic material in medical use, comprises the steps:
(1) each raw material mix homogeneously in one group of composite material is added to the water, and ultrasonic disperse 1h, obtain dispersion liquid, ultrasonic power is 300W, and the quality of mix homogeneously material and the volume ratio of water are 0.9mg:1mL;
(2) be impregnated into by non-woven fabrics in above-mentioned dispersion liquid, concussion process 12h, the surface area of non-woven fabrics and the volume ratio of dispersion liquid are 1cm
2: 2mL;
(3) re-use dehydrated alcohol and carry out washing 3 times to the non-woven fabrics after dipping, vacuum lyophilization 24h at-10 DEG C, obtains described hemostatic material in medical use.
Embodiment 3
A kind of hemostatic material in medical use, is prepared by one group of composite material and non-woven fabrics and is obtained, and wherein one group of composite material comprises the following raw material according to mass fraction meter: chitin fiber 68 parts, Keratin 10 part, sodium carboxymethyl cellulose 17 parts, polyvinyl alcohol 6 parts.
The preparation method of above-described hemostatic material in medical use, comprises the steps:
(1) each raw material mix homogeneously in one group of composite material is added to the water, and ultrasonic disperse 1h, obtain dispersion liquid, ultrasonic power is 300W, and the quality of mix homogeneously material and the volume ratio of water are 1mg:1mL;
(2) be impregnated into by non-woven fabrics in above-mentioned dispersion liquid, concussion process 12h, the surface area of non-woven fabrics and the volume ratio of dispersion liquid are 1cm
2: 2mL;
(3) re-use dehydrated alcohol and carry out washing 3 times to the non-woven fabrics after dipping, vacuum lyophilization 24h at-10 DEG C, obtains described hemostatic material in medical use.
Embodiment 4
A kind of hemostatic material in medical use, is prepared by one group of composite material and non-woven fabrics and is obtained, and wherein one group of composite material comprises the following raw material according to mass fraction meter: chitin fiber 72 parts, Keratin 13 part, sodium carboxymethyl cellulose 21 parts, polyvinyl alcohol 8 parts.
The preparation method of above-described hemostatic material in medical use, comprises the steps:
(1) each raw material mix homogeneously in one group of composite material is added to the water, and ultrasonic disperse 1h, obtain dispersion liquid, ultrasonic power is 300W, and the quality of mix homogeneously material and the volume ratio of water are 1.1mg:1mL;
(2) be impregnated into by non-woven fabrics in above-mentioned dispersion liquid, concussion process 12h, the surface area of non-woven fabrics and the volume ratio of dispersion liquid are 1cm
2: 2mL;
(3) re-use dehydrated alcohol and carry out washing 3 times to the non-woven fabrics after dipping, vacuum lyophilization 24h at-10 DEG C, obtains described hemostatic material in medical use.
Embodiment 5
A kind of hemostatic material in medical use, prepared by one group of composite material and non-woven fabrics and obtain, wherein one group of composite material comprises the following raw material according to mass fraction meter: chitin fiber 60-75 part, k eratin 6-15 parts, sodium carboxymethyl cellulose 10-25 part, polyvinyl alcohol 5-10 part.
The preparation method of above-described hemostatic material in medical use, comprises the steps:
(1) each raw material mix homogeneously in one group of composite material is added to the water, and ultrasonic disperse 1h, obtain dispersion liquid, ultrasonic power is 300W, and the quality of mix homogeneously material and the volume ratio of water are 1.2mg:1mL;
(2) be impregnated into by non-woven fabrics in above-mentioned dispersion liquid, concussion process 12h, the surface area of non-woven fabrics and the volume ratio of dispersion liquid are 1cm
2: 1mL;
(3) re-use dehydrated alcohol and carry out washing 3 times to the non-woven fabrics after dipping, vacuum lyophilization 24h at-10 DEG C, obtains described hemostatic material in medical use.
Performance test
Carry out performance test to embodiment of the present invention 1-5 products obtained therefrom, result is as following table:
Table 1 properties of product test data
Test event | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
Bleeding stopping period, s | 12 | 11 | 11 | 12 | 12 |
Hot strength, MPa | 10.7 | 11.4 | 12.2 | 11.5 | 10.8 |
Biocompatibility | Without rejection | Without rejection | Without rejection | Without rejection | Without rejection |
As seen from the above table, products obtained therefrom of the present invention has the advantages such as hemostasis is fast, mechanical property is good, biocompatibility is good, wherein embodiment 3 best results.
Claims (5)
1. a hemostatic material in medical use, it is characterized in that, prepared by one group of composite material and non-woven fabrics and obtain, wherein one group of composite material comprises the following raw material according to mass fraction meter: chitin fiber 60-75 part, k eratin 6-15 parts, sodium carboxymethyl cellulose 10-25 part, polyvinyl alcohol 5-10 part.
2. a kind of hemostatic material in medical use according to claim 1, is characterized in that, described one group of composite material comprises the following raw material according to mass fraction meter: chitin fiber 68 parts, Keratin 10 part, sodium carboxymethyl cellulose 17 parts, polyvinyl alcohol 6 parts.
3. the preparation method of a kind of hemostatic material in medical use described in claim 1 or 2, is characterized in that, comprise the steps:
(1) each raw material mix homogeneously in one group of composite material is added to the water, and ultrasonic disperse 1h, obtain dispersion liquid, ultrasonic power is 300W;
(2) non-woven fabrics is impregnated in above-mentioned dispersion liquid, concussion process 12h;
(3) re-use dehydrated alcohol and carry out washing 3 times to the non-woven fabrics after dipping, vacuum lyophilization 24h at-10 DEG C, obtains described hemostatic material in medical use.
4. the preparation method of a kind of hemostatic material in medical use according to claim 3, is characterized in that, in described step (1), the quality of mix homogeneously material and the volume ratio of water are 1mg:1mL.
5. the preparation method of a kind of hemostatic material in medical use according to claim 3, is characterized in that, in described step (2), the surface area of non-woven fabrics and the volume ratio of dispersion liquid are 1cm
2: 2mL.
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105854071A (en) * | 2016-04-01 | 2016-08-17 | 石琦 | Vaginal packing hemostatic material and preparation method thereof |
CN106421888A (en) * | 2016-11-01 | 2017-02-22 | 北京东方艾美生物技术股份有限公司 | Keratin-chitosan composite medical dressing and preparation method thereof |
CN108914382A (en) * | 2018-07-27 | 2018-11-30 | 铜陵熙成塑料制品有限公司 | A kind of water suction antibacterial nonwoven cloth |
CN108939140A (en) * | 2018-08-14 | 2018-12-07 | 中山大学 | Composition for hemostasis and medical hemostatic dressing |
CN112156224A (en) * | 2020-01-20 | 2021-01-01 | 海南海默斯医学生物科技有限公司 | Composition for preparing keratin liquid dressing and preparation method and application thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102137684A (en) * | 2008-04-25 | 2011-07-27 | 医疗行业产品有限公司 | Haemostatic material |
CN103656734A (en) * | 2012-09-21 | 2014-03-26 | 青岛道合生物科技有限公司 | Wound-healing dressing film |
WO2014074503A1 (en) * | 2012-11-06 | 2014-05-15 | Imbed Biosciences, Inc. | Methods and compositions for wound healing |
CN103800940A (en) * | 2012-11-14 | 2014-05-21 | 天津禹王生物医药科技有限公司 | Hemostatic application and preparation method thereof |
-
2015
- 2015-09-30 CN CN201510639513.1A patent/CN105251036A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102137684A (en) * | 2008-04-25 | 2011-07-27 | 医疗行业产品有限公司 | Haemostatic material |
CN103656734A (en) * | 2012-09-21 | 2014-03-26 | 青岛道合生物科技有限公司 | Wound-healing dressing film |
WO2014074503A1 (en) * | 2012-11-06 | 2014-05-15 | Imbed Biosciences, Inc. | Methods and compositions for wound healing |
CN103800940A (en) * | 2012-11-14 | 2014-05-21 | 天津禹王生物医药科技有限公司 | Hemostatic application and preparation method thereof |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105854071A (en) * | 2016-04-01 | 2016-08-17 | 石琦 | Vaginal packing hemostatic material and preparation method thereof |
CN106421888A (en) * | 2016-11-01 | 2017-02-22 | 北京东方艾美生物技术股份有限公司 | Keratin-chitosan composite medical dressing and preparation method thereof |
CN108914382A (en) * | 2018-07-27 | 2018-11-30 | 铜陵熙成塑料制品有限公司 | A kind of water suction antibacterial nonwoven cloth |
CN108939140A (en) * | 2018-08-14 | 2018-12-07 | 中山大学 | Composition for hemostasis and medical hemostatic dressing |
CN112156224A (en) * | 2020-01-20 | 2021-01-01 | 海南海默斯医学生物科技有限公司 | Composition for preparing keratin liquid dressing and preparation method and application thereof |
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Application publication date: 20160120 |