CN104721874A - Polysaccharide styptic powder, preparation method thereof and application - Google Patents
Polysaccharide styptic powder, preparation method thereof and application Download PDFInfo
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Abstract
The invention relates to polysaccharide styptic powder, a preparation method thereof and an application. The preparation method comprises the following steps of using plant native starch and etherified starch as raw materials; treating the plant native starch and the etherified starch by using a microwave oven and glycerol; performing emulsion dispersion on the plant native starch and the etherified starch by using span 80, tween 80 and vegetable oil under the conditions that the pH (potential of hydrogen) is 9-10 and the temperature is 45-70 DEG C; performing crosslinking on the plant native starch and the etherified starch by using sodium trimetaphosphate; performing extraction and skimming on the plant native starch and the etherified starch by using ethyl acetate; washing the plant native starch and the etherified starch by using absolute ethyl alcohol; and drying the plant native starch and the etherified starch by using an oven and performing sterilization so as to obtain the polysaccharide styptic powder. The polysaccharide styptic powder has high biocompatibility, can be directly used for stopping general bleeding, deep bleeding and bleeding of parts at which a surgical tool cannot reach, and is easy and convenient to use. The starch serves as the raw materials of the styptic powder and is non-toxic and non-irritant, the sources of the starch are extensive, the cost is low, a technology is simple and feasible, and the polysaccharide styptic powder has a wide clinical application prospect.
Description
Technical field
The invention belongs to biological medicine Material Field, be specifically related to a kind of polysaccharide styptic powder and preparation method thereof, application.
Background technology
Hemorrhage is one of problem needing solution badly in surgical operation, normal human all has hemostatic function, slowly a small amount of hemorrhage self function that can rely on is stopped blooding, but the disguised oozing phenomenon body that, internal organs etc. hemorrhage for human body artery in various sudden accident breaks can not stop blooding voluntarily, only can not lean on common tourniquet bandage hemostasis by compression, intraoperative hemorrhage too much makes operating time extend, heavy then occur serious complication, as hemorrhagic shock, even entail dangers to life and health.Effective Hemostasis conventional is at present the resorbable material hemostasis adopting biocompatibility, and in the hemostasis such as surgical operation, first aid, provide a kind of safe and effective, easy to use, hemostatic material with low cost seems particularly important.
At present, the hemostatic material used clinically mainly contains Fibrin Glue, collagen protein, gelfoam and cellulose hemostatic material, these materials all achieve good effect in zoopery and clinical practice, but also all come with some shortcomings: its raw material sources of collagen are in animal tissue, it is foreign protein, easily there is rejection, there is potential sensitization; Gelatin infiltration rate is slow, general more than 4 weeks, can increase the infection risk of wound; Cellulose family, human body lacks the enzyme making it degrade, and degradation time is long, may bring the side effect such as infection to patient.
Starch is plant polysaccharide, its good biocompatibility, nontoxic, non-stimulated, the anaphylaxis that not easily causes body, and can be monosaccharide by the amylase degrades in body fluid in vivo, degradation in vivo absorbs.Etherification starch is a class modified starch, is the starch substituent group ether that hydroxyl in starch molecule and reactivity substance reaction generate, improves viscosity stability, stablize in the basic conditions, have stronger water absorption and dilatancy.Starch hemostatic material representative is at present Arista styptic powder produced in USA, although its haemostatic effect is good, it adopts epichlorohydrin cross-linked, there is genotoxic potential, and expensive, limits its application.
Summary of the invention
In order to solve the deficiencies in the prior art, the invention provides a kind of polysaccharide styptic powder and its preparation method and application, this styptic powder has good biocompatibility, can by body degraded and absorbed, safety non-toxic, technique simple possible, can directly act on generally hemorrhage, Hemorrhage in Deep and the unapproachable position of operation technique hemorrhage, easy to use, and provide the preparation method of this styptic powder.
A kind of polysaccharide styptic powder, its main component is plant ative starch, etherification starch, and its weight ratio is (1-100): (5-100).
Further, described polysaccharide styptic powder is by described plant ative starch and described etherification starch respectively after microwave-glycerol process, more obtained through emulsification and cross linked.
Further, described etherification starch is one or more in carboxymethyl starch, hetastarch, hydroxypropyl starch, hydroxymethyl starch, cationic starch etc.
Further, the percentage by weight of described plant ative starch and described etherification starch is 4:5.
The present invention also provides the preparation method of above-mentioned polysaccharide styptic powder, it is specially: plant ative starch and etherification starch are distinguished water-soluble with in the blended liquid of glycerol, then carry out microwave heating treatment respectively, obtain two kinds of soluble starches, then by blended soluble in water for two kinds of obtained soluble starches, disperse through emulsifier, cross-linking agents, extractant extracting, washing, dry, namely sterilizing obtains absorbability starch hemostatic powder.
Further, described by the blended liquid of plant ative starch and etherification starch water-soluble and glycerol respectively, the step of then carrying out microwave heating treatment is respectively specially:
Microwave-glycerol process starch: plant ative starch and etherification starch are dissolved in respectively volume ratio for (1-2): in the water-glycerol blended liquid of (1-2), after stirring, make the farinaceous size that mass volume ratio is 10-25%, again respectively through microwave treatment, microwave treatment power is 700-800W, and microwave treatment time is 5-8min, microwave treatment temperature is 80-90 DEG C, through cooling sucking filtration, absolute ethanol washing, drying obtains two kinds of soluble starches of microwave treatment.
Further, described by blended soluble in water for two kinds of obtained soluble starches, through emulsifier dispersion, cross-linking agents, extractant extracting, washing, dry, namely sterilizing obtains the step of absorbability starch hemostatic powder, specifically comprises:
Prepare mixing starch suspension: by weight for (1-100): (5-100) takes a certain amount of ative starch after microwave-glycerol process and etherification starch, add in 20-40 distilled water doubly, after stirring, regulate pH9-10 with sodium hydroxide;
Produce mixing starch emulsion: take class of a certain amount of department 80 and Tween 80 makes blended emulsifier by weight 1:1, mix with vegetable oil again, 45-70 DEG C of water bath with thermostatic control is stirred 10-30min and is stirred, then is joined by emulsion in described starch suspension, stirs 10-30min; Wherein, the envelope-bulk to weight ratio of described vegetable oil and described mixing starch is 15-100:1, ml/g, and the weight ratio of blended emulsifier and mixing starch is 0.5-2.5:1, g/g;
Cross-linking reaction: take a certain amount of sodium trimetaphosphate and be dissolved in distilled water, then joins in described mixing starch emulsion, and stir 2-8h, the mass ratio of sodium trimetaphosphate and mixing starch is 0.01-0.2:1, g/g;
Extracting extracts: by the mixing starch emulsion liquid stratification after cross-linking reaction, abandon supernatant, the ethyl acetate of 5-10 times of volume is added in lower floor's milky white liquid, stratification after abundant stirring, take off a layer milky white liquid, add 2-5 absolute ethyl alcohol and stirring cleaning doubly, then vacuum filtration is to moisture pump, obtains pressed powder;
Prepare polysaccharide styptic powder: be dissolved in the distilled water of 3-5 times of volume by extracting through extracting the powder obtained, magnetic agitation, stratification again, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, place in thermostatic drying chamber dry by the milky white liquid finally obtained, namely sterilizing obtains this polysaccharide styptic powder.
Further, described plant ative starch is potato starch, corn starch, sweet potato starch, one or more in wheaten starch, described etherification starch is one or more in carboxymethyl starch, hetastarch, hydroxypropyl starch, hydroxymethyl starch, cationic starch etc., and/or described vegetable oil is bean plant oil.
Further, the percentage by weight of described plant ative starch and described etherification starch is 4:5.
Product of the present invention adopts good biocompatibility, degradable absorbs, the starch of safety non-toxic is that raw material prepares, bleeding part can be directly acted on, moisture in rapid absorbing blood, reduce blood flowing speed, erythrocyte and PC increase, blood self-solidifying, plays the effect of hemostasis by compression simultaneously after material imbibition.The present invention processes starch by adopting microwave-glycerol, water absorbent rate and the rate of water absorption of starch can be improved, absorbable hemostasia powder prepared by the present invention, can significantly improve its water absorption, have efficient anastalsis, preparation technology is simple simultaneously, be easy to suitability for industrialized production, with low cost, can be used for various operating generally hemorrhage, Hemorrhage in Deep and the unapproachable position of operation technique hemorrhage, easy to use.
Specific embodiment
In order to understand technical scheme of the present invention better, be described in further detail by following specific embodiment, but protection scope of the present invention is not limited only to following embodiment.
Embodiment 1:
1) take 20g potato starch, 25g carboxymethyl starch is dissolved in the mixed solution of distilled water and glycerol respectively, make serosity, wherein, the volume ratio of distilled water and glycerol is 1:1, make the starch solution that mass volume ratio is 10%, be then placed in microwave oven, carry out microwave treatment, microwave treatment power is 800W, microwave treatment time is 5min, and microwave treatment temperature is 85 DEG C, through cooling sucking filtration, absolute ethanol washing, drying obtains two kinds of soluble starches of microwave treatment;
2) by weight the potato starch 0.1g taken respectively for 1:100 in step 1) after microwave-glycerol process, carboxymethyl starch 10g, mixing is dissolved in 350ml distilled water, regulates pH to 9-10 after stirring with sodium hydroxide, obtained mixing starch suspension;
3) take class of 7g department 80 respectively and Tween 80 mixing is dissolved in the vegetable oil of 800ml, 50 ± 5 DEG C are stirred 20min, and obtained mixing and emulsifying dispersant, then adds step 2) in obtained mixing starch suspension stir 20min, obtained mixing starch emulsified dispersed liquid;
4) taking 0.3g sodium trimetaphosphate is dissolved in distilled water, is stirred to and dissolves completely, makes sodium trimetaphosphate solution, then adds in the obtained mixing starch emulsion of step 3), stirs, cross-linking reaction 4h, obtained crosslinked fluid;
5) the crosslinked fluid stratification will obtained in step 4), abandon supernatant, after the ethyl acetate adding 5 times of volumes in lower floor's milky white liquid stirs, stratification, take off the absolute ethanol washing that layer milky white liquid adds 3 times of volumes, stratification after stirring, abandons supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle;
6) solid particle that step 5) obtains is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, place in thermostatic drying chamber dry by the milky white liquid finally obtained, namely sterilizing obtains this polysaccharide styptic powder.
Embodiment 2:
1) take 20g potato starch, 25g hetastarch is dissolved in the mixed solution of distilled water and glycerol respectively, make serosity, wherein, the volume ratio of distilled water and glycerol is 1:2, make the starch solution that mass volume ratio is 20%, be then placed in microwave oven, carry out microwave treatment, microwave treatment power is 800W, microwave treatment time is 5min, and microwave treatment temperature is 85 DEG C, through cooling sucking filtration, absolute ethanol washing, drying obtains two kinds of soluble starches of microwave treatment;
2) by weight the sweet potato starch 2g taken respectively for 1:5 in step 1) after microwave-glycerol process, hetastarch 10g, mixing is dissolved in 400ml distilled water, regulates pH to 9-10 after stirring with sodium hydroxide, obtained mixing starch suspension;
3) take class of 7.5g department 80 respectively and Tween 80 mixing is dissolved in the vegetable oil of 800ml, 50 ± 5 DEG C are stirred 15min, and obtained mixing and emulsifying dispersant, then adds step 2) in obtained mixing starch suspension stir 20min, obtained mixing starch emulsified dispersed liquid;
4) taking 0.4g sodium trimetaphosphate is dissolved in distilled water, is stirred to and dissolves completely, makes sodium trimetaphosphate solution, then adds in the obtained mixing starch emulsion of step 3), stirs, cross-linking reaction 5h, obtained crosslinked fluid;
5) the crosslinked fluid stratification will obtained in step 4), abandon supernatant, after the ethyl acetate adding 5 times of volumes in lower floor's milky white liquid stirs, stratification, take off the absolute ethanol washing that layer milky white liquid adds 3 times of volumes, stratification after stirring, abandons supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle;
6) solid particle that step 5) obtains is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, place in thermostatic drying chamber dry by the milky white liquid finally obtained, namely sterilizing obtains this polysaccharide styptic powder.
Embodiment 3:
1) take 20g potato starch, 25g carboxymethyl starch is dissolved in the mixed solution of distilled water and glycerol respectively, make serosity, wherein, the volume ratio of distilled water and glycerol is 2:1, make the starch solution that mass volume ratio is 30%, be then placed in microwave oven, carry out microwave treatment, microwave treatment power is 700W, microwave treatment time is 5min, and microwave treatment temperature is 85 DEG C, through cooling sucking filtration, absolute ethanol washing, drying obtains two kinds of soluble starches of microwave treatment;
2) by weight the potato starch 5g taken respectively for 1:2 in step 1) after microwave-glycerol process, carboxymethyl starch 10g, mixing is dissolved in 450ml distilled water, regulates pH to 9-10 after stirring with sodium hydroxide, obtained mixing starch suspension;
3) take class of 7g department 80 respectively and Tween 80 mixing is dissolved in the vegetable oil of 800ml, 50 ± 5 DEG C are stirred 15min, and obtained mixing and emulsifying dispersant, then adds step 2) in obtained mixing starch suspension stir 20min, obtained mixing starch emulsified dispersed liquid;
4) taking 0.3g sodium trimetaphosphate is dissolved in distilled water, is stirred to and dissolves completely, makes sodium trimetaphosphate solution, then adds in the obtained mixing starch emulsion of step 3), stirs, cross-linking reaction 4h, obtained crosslinked fluid;
5) the crosslinked fluid stratification will obtained in step 4), abandon supernatant, after the ethyl acetate adding 5 times of volumes in lower floor's milky white liquid stirs, stratification, take off the absolute ethanol washing that layer milky white liquid adds 3 times of volumes, stratification after stirring, abandons supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle;
6) solid particle that step 5) obtains is dissolved in the distilled water of 5 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, place in thermostatic drying chamber dry by the milky white liquid finally obtained, namely sterilizing obtains this polysaccharide styptic powder.
Embodiment 4:
1) take 20g potato starch, 25g carboxymethyl starch is dissolved in the mixed solution of distilled water and glycerol respectively, make serosity, wherein, the volume ratio of distilled water and glycerol is 1:1, make the starch solution that mass volume ratio is 10%, be then placed in microwave oven, carry out microwave treatment, microwave treatment power is 750W, microwave treatment time is 8min, and microwave treatment temperature is 90 DEG C, through cooling sucking filtration, absolute ethanol washing, drying obtains two kinds of soluble starches of microwave treatment;
2) by weight the potato starch 5g taken respectively for 1:1 in step 1) after microwave-glycerol process, carboxymethyl starch 10g, mixing is dissolved in 450ml distilled water, regulates pH to 9-10 after stirring with sodium hydroxide, obtained mixing starch suspension;
3) take class of 8g department 80 respectively and Tween 80 mixing is dissolved in the vegetable oil of 800ml, 50 ± 5 DEG C are stirred 20min, and obtained mixing and emulsifying dispersant, then adds step 2) in obtained mixing starch suspension stir 20min, obtained mixing starch emulsified dispersed liquid;
4) taking 0.8g sodium trimetaphosphate is dissolved in distilled water, is stirred to and dissolves completely, makes sodium trimetaphosphate solution, then adds in the obtained mixing starch emulsion of step 3), stirs, cross-linking reaction 4h, obtained crosslinked fluid;
5) the crosslinked fluid stratification will obtained in step 4), abandon supernatant, after the ethyl acetate adding 5 times of volumes in lower floor's milky white liquid stirs, stratification, take off the absolute ethanol washing that layer milky white liquid adds 3 times of volumes, stratification after stirring, abandons supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle;
6) solid particle that step 5) obtains is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, place in thermostatic drying chamber dry by the milky white liquid finally obtained, namely sterilizing obtains this polysaccharide styptic powder.
Embodiment 5:
1) take 20g potato starch, 25g carboxymethyl starch is dissolved in the mixed solution of distilled water and glycerol respectively, make serosity, wherein, the volume ratio of distilled water and glycerol is 1:1, make the starch solution that mass volume ratio is 10%, be then placed in microwave oven, carry out microwave treatment, microwave treatment power is 750W, microwave treatment time is 8min, and microwave treatment temperature is 90 DEG C, through cooling sucking filtration, absolute ethanol washing, drying obtains two kinds of soluble starches of microwave treatment;
2) by weight the potato starch 10g taken respectively for 100:1 in step 1) after microwave-glycerol process, carboxymethyl starch 0.1g, mixing is dissolved in 200ml distilled water, regulates pH to 9-10 after stirring with sodium hydroxide, obtained mixing starch suspension;
3) take class of 5g department 80 respectively and Tween 80 mixing is dissolved in the vegetable oil of 1000ml, 50 ± 5 DEG C are stirred 20min, and obtained mixing and emulsifying dispersant, then adds step 2) in obtained mixing starch suspension stir 20min, obtained mixing starch emulsified dispersed liquid;
4) taking 0.3g sodium trimetaphosphate is dissolved in distilled water, is stirred to and dissolves completely, makes sodium trimetaphosphate solution, then adds in the obtained mixing starch emulsion of step 3), stirs, cross-linking reaction 4h, obtained crosslinked fluid;
5) the crosslinked fluid stratification will obtained in step 4), abandon supernatant, after the ethyl acetate adding 5 times of volumes in lower floor's milky white liquid stirs, stratification, take off the absolute ethanol washing that layer milky white liquid adds 3 times of volumes, stratification after stirring, abandons supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle;
6) solid particle that step 5) obtains is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, place in thermostatic drying chamber dry by the milky white liquid finally obtained, namely sterilizing obtains this polysaccharide styptic powder.
Embodiment 6:
1) take the sweet starch of 20g, 25g carboxymethyl starch is dissolved in the mixed solution of distilled water and glycerol respectively, make serosity, wherein, the volume ratio of distilled water and glycerol is 1:1, make the starch solution that mass volume ratio is 10%, be then placed in microwave oven, carry out microwave treatment, microwave treatment power is 750W, microwave treatment time is 8min, and microwave treatment temperature is 90 DEG C, through cooling sucking filtration, absolute ethanol washing, drying obtains two kinds of soluble starches of microwave treatment;
2) by weight the potato starch 10g taken respectively for 100:1 in step 1) after microwave-glycerol process, carboxymethyl starch 0.1g, mixing is dissolved in 300ml distilled water, regulates pH to 9-10 after stirring with sodium hydroxide, obtained mixing starch suspension;
3) take class of 5g department 80 respectively and Tween 80 mixing is dissolved in the vegetable oil of 800ml, 50 ± 5 DEG C are stirred 20min, and obtained mixing and emulsifying dispersant, then adds step 2) in obtained mixing starch suspension stir 20min, obtained mixing starch emulsified dispersed liquid;
4) taking 0.7g sodium trimetaphosphate is dissolved in distilled water, is stirred to and dissolves completely, makes sodium trimetaphosphate solution, then adds in the obtained mixing starch emulsion of step 3), stirs, cross-linking reaction 7h, obtained crosslinked fluid;
5) the crosslinked fluid stratification will obtained in step 4), abandon supernatant, after the ethyl acetate adding 7 times of volumes in lower floor's milky white liquid stirs, stratification, take off the absolute ethanol washing that layer milky white liquid adds 5 times of volumes, stratification after stirring, abandons supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle;
6) solid particle that step 5) obtains is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, place in thermostatic drying chamber dry by the milky white liquid finally obtained, namely sterilizing obtains this polysaccharide styptic powder.
Claims (10)
1. a polysaccharide styptic powder, is characterized in that, described polysaccharide styptic powder main component is plant ative starch, etherification starch, and its weight ratio is (1-100): (5-100).
2. polysaccharide styptic powder as claimed in claim 1, is characterized in that, described polysaccharide styptic powder be by described plant ative starch with described etherification starch respectively after microwave-glycerol process, then to obtain through emulsification and cross linked.
3. polysaccharide styptic powder as claimed in claim 2, is characterized in that, described etherification starch is one or more in carboxymethyl starch, hetastarch, hydroxypropyl starch, hydroxymethyl starch, cationic starch etc.
4. the polysaccharide styptic powder as described in claim 1 or 2 or 3, is characterized in that, the percentage by weight of described plant ative starch and described etherification starch is 4:5.
5. as the preparation method of the polysaccharide styptic powder in Claims 1-4 as described in any one, it is characterized in that, plant ative starch and etherification starch are distinguished water-soluble with in the blended liquid of glycerol, then carry out microwave heating treatment respectively, obtain two kinds of soluble starches, two kinds of soluble starches again by obtained are blended soluble in water, through emulsifier dispersion, and cross-linking agents, extractant extracting, washing, dry, namely sterilizing obtains absorbability starch hemostatic powder.
6. the preparation method of polysaccharide styptic powder as claimed in claim 5, is characterized in that, described by the blended liquid of plant ative starch and etherification starch water-soluble and glycerol respectively, the step of then carrying out microwave heating treatment is respectively specially:
Plant ative starch and etherification starch are dissolved in respectively volume ratio for (1-2): in the water-glycerol blended liquid of (1-2), after stirring, make the farinaceous size that mass volume ratio is 10-25%, again respectively through microwave treatment, microwave treatment power is 700-800W, and microwave treatment time is 5-8min, microwave treatment temperature is 80-90 DEG C, through cooling sucking filtration, absolute ethanol washing, drying obtains two kinds of soluble starches of microwave treatment.
7. polysaccharide styptic powder preparation method as claimed in claim 6, it is characterized in that, described by blended soluble in water for two kinds of obtained soluble starches, through emulsifier dispersion, cross-linking agents, extractant extracting, washing, dry, namely sterilizing obtains the step of absorbability starch hemostatic powder, specifically comprises:
Prepare mixing starch suspension: by weight for (1-100): (5-100) takes a certain amount of ative starch after microwave-glycerol process and etherification starch, add in 20-40 distilled water doubly, after stirring, regulate pH9-10 with sodium hydroxide;
Produce mixing starch emulsion: take class of a certain amount of department 80 and Tween 80 makes blended emulsifier by weight 1:1, mix with vegetable oil again, 45-70 DEG C of water bath with thermostatic control is stirred 10-30min and is stirred, then is joined by emulsion in described starch suspension, stirs 10-30min; Wherein, the envelope-bulk to weight ratio of described vegetable oil and described mixing starch is 15-100:1, ml/g, and the weight ratio of blended emulsifier and mixing starch is 0.5-2.5:1, g/g;
Cross-linking reaction: take a certain amount of sodium trimetaphosphate and be dissolved in distilled water, then joins in described mixing starch emulsion, and stir 2-8h, the mass ratio of sodium trimetaphosphate and mixing starch is 0.01-0.2:1, g/g;
Extracting extracts: by the mixing starch emulsion liquid stratification after cross-linking reaction, abandon supernatant, the ethyl acetate of 5-10 times of volume is added in lower floor's milky white liquid, stratification after abundant stirring, take off a layer milky white liquid, add 2-5 absolute ethyl alcohol and stirring cleaning doubly, then vacuum filtration is to moisture pump, obtains pressed powder;
Prepare polysaccharide styptic powder: be dissolved in the distilled water of 3-5 times of volume by extracting through extracting the powder obtained, magnetic agitation, stratification again, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, place in thermostatic drying chamber dry by the milky white liquid finally obtained, namely sterilizing obtains this polysaccharide styptic powder.
8. the preparation method of polysaccharide styptic powder as claimed in claim 5, it is characterized in that, described plant ative starch is potato starch, corn starch, sweet potato starch, one or more in wheaten starch, described etherification starch is one or more in carboxymethyl starch, hetastarch, hydroxypropyl starch, hydroxymethyl starch, cationic starch etc.
9. the preparation method of polysaccharide styptic powder as claimed in claim 5, is characterized in that, described vegetable oil is bean plant oil.
10. as the application of the polysaccharide styptic powder in Claims 1-4 as described in any one, it is characterized in that, be applied to various traumatic hemorrhage, surgical operation wound surface is hemorrhage, oozing of blood, hemorrhage etc. the hemostasis of Hemorrhage in Deep and the unapproachable position of operation technique.
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| CN106073992A (en) * | 2016-05-25 | 2016-11-09 | 重庆联佰博超医疗器械有限公司 | The buffering dressing of absorbability composite wound |
| CN106377792A (en) * | 2016-09-29 | 2017-02-08 | 江苏华能药业有限公司 | Compound micro-porous cross-linked starch styptic powder |
| CN106377792B (en) * | 2016-09-29 | 2019-12-03 | 江苏华能药业有限公司 | Composite microporous crosslinked starch styptic powder |
| CN108853564A (en) * | 2017-05-08 | 2018-11-23 | 常州药物研究所有限公司 | Hemostasis cross-link dextran particle and preparation method thereof |
| CN108853564B (en) * | 2017-05-08 | 2021-04-06 | 常州药物研究所有限公司 | Cross-linked dextran microparticles for hemostasis and preparation method thereof |
| CN110115776A (en) * | 2018-02-07 | 2019-08-13 | 沈阳药科大学 | A kind of absorbable spherex styptic powder and its application with antibacterial activity |
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