CN105770966A - Absorbable starch styptic powder, preparation method and applications thereof - Google Patents
Absorbable starch styptic powder, preparation method and applications thereof Download PDFInfo
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- CN105770966A CN105770966A CN201410806354.5A CN201410806354A CN105770966A CN 105770966 A CN105770966 A CN 105770966A CN 201410806354 A CN201410806354 A CN 201410806354A CN 105770966 A CN105770966 A CN 105770966A
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Abstract
The invention discloses an absorbable starch styptic powder, and a preparation method thereof. The absorbable starch styptic powder is prepared by the following steps: taking plant origin starch and hydroxyethyl starch as the raw materials, emulsifying and dispersing the starches in span 80, tween 80, and plant oil at a temperature of 45 to 70 DEG C under a pH value of 9 to 10, adding sodium trimetaphosphate to carry out crosslinking, using ethyl acetate to perform extraction and liquid separation, washing the solid by anhydrous ethanol, drying the solid in a baking oven, and performing sterilization to obtain the styptic powder. The styptic powder has a good biocompatibility, can be directly applied to the common bleeding parts, deep bleeding parts, and bleeding parts that are hard to reach through surgery operation, and is simple and convenient to use. Starches are the raw materials of the styptic powder, thus the styptic powder is nontoxic and nonirritant, moreover, the sources of raw materials are wide, the cost is low, the technology is simple and feasible, and thus the styptic powder has a wide clinical application prospect.
Description
Technical field
The invention belongs to biological medicine Material Field, be specifically related to a kind of absorbability starch hemostatic powder and preparation method thereof, application.
Background technology
War wound, emergency care of trauma and surgical operation all can be formed hemorrhage, this problem needs solution badly, normal human is respectively provided with hemostatic function, slowly a small amount of hemorrhage self function can be relied on to stop blooding, but, the disguised oozing phenomenon body broken for hemorrhage, the internal organs of human body artery in various sudden accidents etc. can not stop blooding voluntarily, can not only lean on common tourniquet bandage hemostasis by compression, if patient's severe loss of blood, it is possible to shock, even entail dangers to life and health can be caused.Effective Hemostasis conventional at present is the resorbable material hemostasis of employing biocompatibility, provides a kind of safe and effective in surgical operation, first aid etc. are stopped blooding, and easy to use, hemostatic material with low cost is particularly important.
At present, the hemostatic material used clinically mainly has Fibrin Glue, collagen protein, gelfoam and cellulose hemostatic material, these materials all achieve good effect in zoopery and clinical practice, but also all come with some shortcomings: its raw material sources of collagen are in animal tissue, it it is foreign protein, rejection easily occurs, there is potential sensitization;Gelatin infiltration rate is slow, general more than 4 weeks, can increase the infection risk of wound;Cellulose family, human body lacks makes its enzyme degraded, and degradation time is long, it is possible to can bring the side effect such as infection to patient.
Starch is plant polysaccharide, its good biocompatibility, nontoxic, non-stimulated, not easily cause the anaphylaxis of body, monosaccharide can be degraded to by the amylase in body fluid in vivo, degradation in vivo absorbs.Hetastarch is a kind of modified starch, nontoxic non-stimulated, do not cause inflammation reaction, can be used for treating and preventing hypovolemia, there is maintenance blood colloid osmotic pressure effect, can be used for losing blood, wound, burn etc., be the material of a kind of good biocompatibility, there is stronger water absorption and dilatancy, can comparatively fast steep in cold water and rise.Starch hemostatic material representative at present is Arista styptic powder produced in USA, although its haemostatic effect is good, but it adopts epichlorohydrin cross-linked, there is genotoxic potential, and expensive, limits its application.
Summary of the invention
In order to solve the deficiencies in the prior art, the present invention provides a kind of absorbability starch hemostatic powder and preparation method thereof, application, this styptic powder has efficient anastalsis, good biocompatibility, safety non-toxic, technique simple possible, can be done directly on generally hemorrhage, Hemorrhage in Deep and the unapproachable position of operation technique hemorrhage, easy to use, and the preparation method providing this styptic powder.
A kind of absorbability starch hemostatic powder, its main component is plant ative starch, hetastarch, and its weight ratio is (0.1-10): (10-0.1).
Further, described plant ative starch is 1:2 or 5:2 with the weight ratio of described hetastarch.
Correspondingly, present invention also offers the method preparing this absorbability starch hemostatic powder, it specifically includes and soluble in water obtains mixing starch suspension by blended to plant ative starch and hetastarch, mixing starch emulsion is obtained then through emulsifier dispersion, then through cross-linking agents, extractant extracting, washing, dry, sterilizing, thus obtaining the product absorbability starch hemostatic powder.
Further, described by blended to plant ative starch and the hetastarch step obtaining mixing starch suspension soluble in water, particularly as follows: by weight for (0.1-10): (10-0.1) weighs plant ative starch and hetastarch, it is dissolved in the distilled water of 20-40 times, stir, regulate pH to 9-10 with sodium hydroxide.
Further, the described step obtaining mixing starch emulsion through emulsifier dispersion, it is specially by weight weighing Span 80 for 1:1 and Tween 80 makes blended emulsifier, mix with vegetable oil dispersion again, 10-30min is stirred under 45-70 DEG C of water bath with thermostatic control, make emulsifying dispersant, then above-mentioned mixing starch suspension adds wherein, stirring 10-30min, the envelope-bulk to weight ratio of described vegetable oil and described mixing starch is 15-100:1, the weight ratio of ml/g, blended emulsifier and described mixing starch is 0.5-2.5:1, g/g.
Further, described crosslinked dose of crosslinking, extractant extracting, washing, to dry, the step of sterilizing, thus obtaining the product absorbability starch hemostatic powder specifically includes:
Cross-linking reaction: weigh a certain amount of sodium trimetaphosphate and be dissolved in distilled water, is subsequently adding in starch emulsion, stirring reaction 2-8h, and wherein, the weight ratio of sodium trimetaphosphate and mixing starch is 0.01-0.2:1, g/g;
Extracting extracts: by the mixed solution stratification through cross-linking reaction, abandon supernatant, the ethyl acetate solution of 5-10 times of volume is added in lower floor's milky white liquid, after stirring, stratification, takes off layer milky white liquid and adds the absolute ethanol washing of 2-5 times of volume, stratification after stirring, abandoning supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle;
Prepare styptic powder: be dissolved in the distilled water of 3-5 times of volume by prepared powder, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
Especially, described plant amylum includes potato starch, corn starch, sweet potato starch, one or more in wheaten starch.
Especially, described vegetable oil is bean plant oil.
Product of the present invention adopts good biocompatibility, the starch of safety non-toxic is that raw material prepares, bleeding part can be directly acted on, absorb rapidly the moisture in blood, reduce blood flowing speed, erythrocyte and PC increase, blood self-solidifying, play the effect of hemostasis by compression after material imbibition simultaneously.
Product preparation process of the present invention is simple, with low cost, can be used for various operating generally hemorrhage, Hemorrhage in Deep and the unapproachable position of operation technique is hemorrhage, easy to use.
Specific embodiment
In order to be more fully understood that technical scheme, it is described in further detail by embodiment in detail below, but protection scope of the present invention is not limited only to following embodiment.
Embodiment 1:
1) weighing 0.1g potato starch, 10g hetastarch is dissolved in 300ml distilled water, regulates pH to 9-10 with sodium hydroxide, prepare mixing starch suspension after stirring;
2) weigh 3.5g Span 80 respectively and Tween 80 is dissolved in the vegetable oil of 800ml, 50 ± 5 DEG C of stirring 20min, prepare mixing and emulsifying dispersant, be subsequently adding in mixing starch suspension and stir 20min, prepare mixing starch emulsion;
3) weigh 0.2g sodium trimetaphosphate and be dissolved in distilled water, be subsequently adding in mixing starch emulsion, stirring crosslinking 3h, prepare crosslinked fluid;
4) by crosslinked fluid stratification, abandon supernatant, after in lower floor's milky white liquid, the ethyl acetate of 5 times of volumes of addition stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 3 times of volumes, stratification after stirring, abandon supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle;
5) prepared solid particle is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
Embodiment 2:
1) weighing 5g potato starch, 10g hetastarch is dissolved in 400ml distilled water, regulates pH to 9-10 with sodium hydroxide, prepare mixing starch suspension after stirring;
2) weigh 6g Span 80 respectively and Tween 80 is dissolved in the vegetable oil of 800ml, 50 ± 5 DEG C of stirring 20min, prepare mixing and emulsifying dispersant, be subsequently adding in mixing starch suspension and stir 20min, prepare mixing starch emulsion;
3) weigh 0.2g sodium trimetaphosphate and be dissolved in distilled water, be subsequently adding in mixing starch emulsion, stirring crosslinking 3h, prepare crosslinked fluid;
4) by crosslinked fluid stratification, abandon supernatant, after in lower floor's milky white liquid, the ethyl acetate of 5 times of volumes of addition stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 3 times of volumes, stratification after stirring, abandon supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle;
5) prepared solid particle is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
Embodiment 3:
1) weighing 10g potato starch, 10g hetastarch is dissolved in 700ml distilled water, regulates pH to 9-10 with sodium hydroxide, prepare mixing starch suspension after stirring;
2) weigh 15g Span 80 respectively and Tween 80 is dissolved in the vegetable oil of 800ml, 50 ± 5 DEG C of stirring 15min, prepare mixing and emulsifying dispersant, be subsequently adding in mixing starch suspension and stir 20min, prepare mixing starch emulsion;
3) weigh 0.5g sodium trimetaphosphate and be dissolved in distilled water, be subsequently adding in mixing starch emulsion, stirring crosslinking 5h, prepare crosslinked fluid;
4) by crosslinked fluid stratification, abandon supernatant, after in lower floor's milky white liquid, the ethyl acetate of 5 times of volumes of addition stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 3 times of volumes, stratification after stirring, abandon supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle;
5) prepared solid particle is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
Embodiment 4:
1) weighing 10g potato starch, 4g hetastarch is dissolved in 400ml distilled water, regulates pH to 9-10 with sodium hydroxide, prepare mixing starch suspension after stirring;
2) weigh 7g Span 80 respectively and Tween 80 is dissolved in the vegetable oil of 800ml, 50 ± 5 DEG C of stirring 15min, prepare mixing and emulsifying dispersant, be subsequently adding in mixing starch suspension and stir 20min, prepare mixing starch emulsion;
3) weigh 0.7g sodium trimetaphosphate and be dissolved in distilled water, be subsequently adding in mixing starch emulsion, stirring crosslinking 5h, prepare crosslinked fluid;
4) by crosslinked fluid stratification, abandon supernatant, after in lower floor's milky white liquid, the ethyl acetate of 5 times of volumes of addition stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 3 times of volumes, stratification after stirring, abandon supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle;
5) prepared solid particle is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
Embodiment 5:
1) weighing 10g potato starch, 0.1g hetastarch is dissolved in 300ml distilled water, regulates pH to 9-10 with sodium hydroxide, prepare mixing starch suspension after stirring;
2) weigh 3.5g Span 80 respectively and Tween 80 is dissolved in the vegetable oil of 800ml, 50 ± 5 DEG C of stirring 15min, prepare mixing and emulsifying dispersant, be subsequently adding in mixing starch suspension and stir 20min, prepare mixing starch emulsion;
3) weigh 0.2g sodium trimetaphosphate and be dissolved in distilled water, be subsequently adding in mixing starch emulsion, stirring crosslinking 5h, prepare crosslinked fluid;
4) by crosslinked fluid stratification, abandon supernatant, after in lower floor's milky white liquid, the ethyl acetate of 8 times of volumes of addition stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 4 times of volumes, stratification after stirring, abandon supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle;
5) prepared solid particle is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
Embodiment 6:
1) weighing 10g sweet potato starch, 10g hetastarch is dissolved in 500ml distilled water, regulates pH to 9-10 with sodium hydroxide, prepare mixing starch suspension after stirring;
2) weigh 4g Span 80 respectively and Tween 80 is dissolved in the vegetable oil of 800ml, 60 ± 5 DEG C of stirring 15min, prepare mixing and emulsifying dispersant, be subsequently adding in mixing starch suspension and stir 30min, prepare mixing starch emulsion;
3) weigh 0.4g sodium trimetaphosphate and be dissolved in distilled water, be subsequently adding in mixing starch emulsion, stirring crosslinking 5h, prepare crosslinked fluid;
4) by crosslinked fluid stratification, abandon supernatant, after in lower floor's milky white liquid, the ethyl acetate of 10 times of volumes of addition stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 4 times of volumes, stratification after stirring, abandon supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle;
5) prepared solid particle is dissolved in the distilled water of 5 times of volumes, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
Claims (10)
1. an absorbability starch hemostatic powder, it is characterised in that described absorbability starch hemostatic powder main component is plant ative starch, hetastarch, and its weight ratio is (0.1-10): (10-0.1).
2. absorbability starch hemostatic powder as claimed in claim 1, it is characterised in that described plant ative starch is potato starch, corn starch, sweet potato starch, one or more in wheaten starch.
3. absorbability starch hemostatic powder as claimed in claim 1 or 2, it is characterised in that the weight ratio of described plant ative starch and described hetastarch is 1:2 or 5:2.
4. the preparation method of absorbability starch hemostatic powder as claimed in claim 1 or 2, it is characterized in that, including: soluble in water obtain mixing starch suspension by blended to plant ative starch and hetastarch, mixing starch emulsion is obtained then through emulsifier dispersion, then through cross-linking agents, extractant extracting, washing, dry, sterilizing, thus obtaining the product absorbability starch hemostatic powder.
5. the preparation method of absorbability starch hemostatic powder as claimed in claim 4, it is characterised in that described by blended to plant ative starch and the hetastarch step obtaining mixing starch suspension soluble in water, particularly as follows:
By weight for (0.1-10): (10-0.1) weighs plant ative starch and hetastarch, adds in the distilled water of 20-40 times, after stirring, regulates pH9-10 with sodium hydroxide.
6. the preparation method of absorbability starch hemostatic powder as claimed in claim 4, it is characterized in that, the described step obtaining mixing starch emulsion through emulsifier dispersion, particularly as follows: by weight 1:1 weighs Span 80, Tween 80 makes blended emulsifier, mix with vegetable oil again, 45-70 DEG C of water bath with thermostatic control stirring 10-30min stirs, then is joined by emulsified dispersed liquid in the above-mentioned mixing starch suspension produced, and stirs 10-30min;Wherein, the envelope-bulk to weight ratio of described vegetable oil and described mixing starch is 15-100:1, ml/g, and the weight ratio of blended emulsifier and described mixing starch is 0.5-2.5:1, g/g.
7. the preparation method that can absorb starch hemostatic powder as claimed in claim 4, it is characterised in that described crosslinked dose of crosslinking, extractant extracting, washing, to dry, the step of sterilizing, thus obtaining the product absorbability starch hemostatic powder specifically includes:
Cross-linking reaction: weigh a certain amount of sodium trimetaphosphate and be dissolved in distilled water, is then added in above-mentioned mixing starch emulsion, and the mass ratio stirring 2-8h, sodium trimetaphosphate and mixing starch is 0.01-0.2:1, g/g;
Extracting extracts: by the above-mentioned product stratification through cross-linking reaction, abandon supernatant, the ethyl acetate of 5-10 times of volume is added in lower floor's milky white liquid, it is sufficiently stirred for rear stratification, take off a layer milky white liquid, the absolute ethyl alcohol and stirring adding 2-5 times is cleaned, and then vacuum filtration is to moisture pump, obtains pressed powder;
Prepare styptic powder: be dissolved in the distilled water of 3-5 times of volume by powder obtained above, magnetic agitation, then stratification, abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, placing in thermostatic drying chamber dry by the milky white liquid that finally obtains, sterilizing, thus obtaining the product is to this starch hemostatic powder.
8. the preparation method of absorbability starch hemostatic powder as claimed in claim 5, it is characterised in that the weight ratio of described plant ative starch and described hetastarch is 1:2 or 5:2.
9. the preparation method of the absorbability starch hemostatic powder as described in any one in claim 4 to 8, it is characterised in that described plant ative starch is potato starch, corn starch, sweet potato starch, one or more in wheaten starch.
10. the hemostasis that the application of absorbability starch hemostatic powder as described in any one in claims 1 to 3, it is characterised in that being applied to various traumatic hemorrhage, surgical operation wound surface is hemorrhage, oozing of blood, Hemorrhage in Deep and the unapproachable position of operation technique are hemorrhage etc..
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106377792A (en) * | 2016-09-29 | 2017-02-08 | 江苏华能药业有限公司 | Compound micro-porous cross-linked starch styptic powder |
CN113912870A (en) * | 2021-11-12 | 2022-01-11 | 重庆联佰博超医疗器械有限公司 | Starch modification method and application |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101121041A (en) * | 2007-08-09 | 2008-02-13 | 美国淀粉医疗公司 | Denaturated starch absorbable hemostatic material and preparation method thereof |
WO2009018126A2 (en) * | 2007-08-01 | 2009-02-05 | Ethicon, Inc. | Collagen-related peptides and uses thereof |
CN101485897A (en) * | 2008-01-14 | 2009-07-22 | 纪欣 | Biocompatible hemostatic, antiblocking, healing-promoting and surgical wound-closing modified starch material |
CN102302796A (en) * | 2011-09-08 | 2012-01-04 | 江苏天麟生物医药科技有限公司 | Absorptive hemostatic biological material and preparation method thereof |
CN102406956A (en) * | 2011-03-09 | 2012-04-11 | 天津爱勒易医药材料有限公司 | Starch hemostatic microsphere and preparation method thereof |
-
2014
- 2014-12-23 CN CN201410806354.5A patent/CN105770966A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009018126A2 (en) * | 2007-08-01 | 2009-02-05 | Ethicon, Inc. | Collagen-related peptides and uses thereof |
CN101121041A (en) * | 2007-08-09 | 2008-02-13 | 美国淀粉医疗公司 | Denaturated starch absorbable hemostatic material and preparation method thereof |
CN101361986A (en) * | 2007-08-09 | 2009-02-11 | 美国淀粉医疗公司 | Modified starch absorbable hemostasia material and preparation method thereof |
CN101485897A (en) * | 2008-01-14 | 2009-07-22 | 纪欣 | Biocompatible hemostatic, antiblocking, healing-promoting and surgical wound-closing modified starch material |
CN102406956A (en) * | 2011-03-09 | 2012-04-11 | 天津爱勒易医药材料有限公司 | Starch hemostatic microsphere and preparation method thereof |
CN102302796A (en) * | 2011-09-08 | 2012-01-04 | 江苏天麟生物医药科技有限公司 | Absorptive hemostatic biological material and preparation method thereof |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106377792A (en) * | 2016-09-29 | 2017-02-08 | 江苏华能药业有限公司 | Compound micro-porous cross-linked starch styptic powder |
CN106377792B (en) * | 2016-09-29 | 2019-12-03 | 江苏华能药业有限公司 | Composite microporous crosslinked starch styptic powder |
CN113912870A (en) * | 2021-11-12 | 2022-01-11 | 重庆联佰博超医疗器械有限公司 | Starch modification method and application |
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