CN105727345A - Absorbable hemostasis membrane material and preparation method thereof - Google Patents
Absorbable hemostasis membrane material and preparation method thereof Download PDFInfo
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- CN105727345A CN105727345A CN201410748904.2A CN201410748904A CN105727345A CN 105727345 A CN105727345 A CN 105727345A CN 201410748904 A CN201410748904 A CN 201410748904A CN 105727345 A CN105727345 A CN 105727345A
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Abstract
The invention relates to an absorbable hemostasis membrane material. The absorbable hemostasis membrane material mainly contains starch, carboxymethylcellulose and gelatin, wherein the weight ratio of the starch to the carboxymethylcellulose to the gelatin is (1-4) to (1-2) to (1-3). The invention further discloses a preparation method of the absorbable hemostasis membrane material. According to the preparation method, a prepared starch solution, a prepared carboxymethylcellulose solution and a prepared gelatin solution are mixed uniformly through a stirring-blending method, thus the membrane material is prepared. The hemostasis membrane material prepared by the preparation method disclosed by the invention has good biocompatibility as well as good absorbable degradation, and has the adhesion-preventing effect while having the hemostasis function. In addition, the composite haemostatic material has the advantages that the raw materials are wide in source, the membrane material is safe and non-toxic, and a preparation technology is simple.
Description
Technical field
The invention belongs to biological medicine Material Field, be specifically related to a kind of absorbable hemostasia membrane material and preparation method thereof.
Background technology
War wound, emergency care of trauma and operating bleeding problems need solution badly.Normal human is respectively provided with hemostatic function, slowly a small amount of hemorrhage self function can be relied on to stop blooding, but, the disguised oozing phenomenon body broken for human body massive hemorrhage phenomenon, internal organs etc. in various sudden accidents can not stop blooding voluntarily, if patient's severe loss of blood, may result in shock, even entail dangers to life and health.In recent years, development along with medical science, biotechnology and material science, various novel hemostatic materials constantly come out, along with improving constantly hemostatic material performance requirement, exploitation haemostatic effect more preferably, there is good biocompatibility, the hemostatic material in medical use that has no side effect imperative.
Starch is plant polysaccharide, its good biocompatibility, nontoxic, non-stimulated, not easily cause the anaphylaxis of body, when it contacts with wound surface, powerful water absorption can reduce blood flowing speed, makes erythrocyte and PC increase, and excites blood self-solidifying mechanism；Starch hemostatic material representative at present is Arista styptic powder produced in USA, although its haemostatic effect is good, but still Shortcomings: first, adopt epichlorohydrin cross-linked, there is genotoxic potential；Two is that cohesiveness is not good；Three is expensive, limits its application.
Carboxymethyl cellulose (CMC), is a kind of plant polysaccharides, has good biocompatibility and biodegradability, safety non-toxic, to skin, mucosa nonirritant, without immunoreation, in the process of tissue injury healing, has agglutinant effect.
Gelatin is a kind of natural absorbable material being widely used in biomedical sector, and good biocompatibility is nontoxic non-stimulated, and molecular structure has substantial amounts of hydroxyl, amino and carboxyl, is a kind of amphiprotic substance, has extremely strong hydrophilic；It is placed in bleeding part, absorbs blood rapidly, cause plaque rupture, promote blood coagulation, reach the purpose of hemostasis, there is adhesion simultaneously, well can attach with wound surface.
Compound hemostatic film prepared by the present invention has efficient anastalsis, has good adhesion simultaneously, well can attach with wound surface, has no report with the Patent Domestic that starch, carboxymethyl cellulose and gelatin prepare hemostatic material for raw material.
Summary of the invention
It is an object of the invention to make up above-mentioned the deficiencies in the prior art, it is provided that a kind of absorbable and degradable, safety non-toxic efficient hemostatic material, this hemostatic material has certain promoting healing effect simultaneously.
The preparation method of the absorbable hemostasia membrane material of the present invention, comprises the steps:
1) weighing a certain amount of starch and be dissolved in deionized water, uniform stirring is to being completely dissolved, and obtaining concentration is 0.5～5.0%(W/V) starch solution, standby；
2) weighing a certain amount of carboxymethyl cellulose and be dissolved in deionized water, uniform stirring is to being completely dissolved, and obtaining concentration is 0.5～0.7%(W/V) cmc soln, standby；
3) weighing a certain amount of gelatin and be dissolved in deionized water, 30 DEG C of heated and stirred are to being completely dissolved, and obtaining concentration is 0.5～1.5%(W/V) gelatin solution, standby；
4) by step 1), 2), 3) in the starch solution of preparation, cmc soln and gelatin solution by weight (1～4): (1～2): (1～3) is blended, prepare blended liquid, again blended liquid is filtered, vacuum deaerator, casting film-forming after standing, is drying to obtain absorbable hemostasia film.
Preferably, described starch is the one in carboxymethyl starch, hydroxypropyl starch, enzyme change starch, etherification starch etc..
The absorbable hemostasia membrane material that the present invention is prepared in aforementioned manners, it it is a kind of efficient hemostatic material with good biocompatibility, absorbable and degradable, safety non-toxic, this hemostatic material has certain biocidal property and promoting healing effect simultaneously, and raw material sources are extensive, and preparation technology is simple.
Specific embodiment
In order to be more fully understood that technical scheme, it is described in further detail by embodiment in detail below, but protection scope of the present invention is not limited only to following embodiment.
Embodiment 1:
Weighing 3g starch and be dissolved in deionized water, uniform stirring, to being completely dissolved, obtains the starch solution that mass body volume concentrations is 3%, standby；Weighing the carboxymethyl cellulose of 1g, heating is dissolved in deionized water, and uniform stirring, to being completely dissolved, obtains the cmc soln that mass body volume concentrations is 0.5%, standby；Weighing 1g gelatin and be dissolved in deionized water, 30 DEG C of heated and stirred, to being completely dissolved, obtain the gelatin solution that mass body volume concentrations is 1.0%, standby；By the starch solution of preparation, cmc soln and gelatin solution by weight blended for 2:1:2, stir, prepare blended liquid, then blended liquid is filtered, vacuum deaerator, casting film-forming after standing, be drying to obtain absorbable hemostasia membrane material.
Embodiment 2:
Weighing 3g starch and be dissolved in deionized water, uniform stirring, to being completely dissolved, obtains the starch solution that mass volume ratio is 5%, standby；Weighing the carboxymethyl cellulose of 1g, heating is dissolved in deionized water, and uniform stirring, to being completely dissolved, obtains the cmc soln that mass volume ratio is 0.6%, standby；The gelatin weighing 1g is dissolved in deionized water, and 30 DEG C of heated and stirred, to being completely dissolved, obtain the gelatin solution that mass volume ratio is 0.5%, standby；By the starch solution of preparation, cmc soln and gelatin solution by weight blended for 2:1:2, stir, prepare blended liquid, then blended liquid is filtered, vacuum deaerator, casting film-forming after standing, be drying to obtain absorbable hemostasia membrane material.
Embodiment 3:
Weighing 4g starch and be dissolved in deionized water, uniform stirring, to being completely dissolved, obtains the starch solution that mass volume ratio is 3.5%, standby；Weighing the carboxymethyl cellulose of 1.5g, heating is dissolved in deionized water, and uniform stirring, to being completely dissolved, obtains the cmc soln that mass volume ratio is 0.7%, standby；The gelatin weighing 2g is dissolved in deionized water, and 30 DEG C of heated and stirred, to being completely dissolved, obtain the gelatin solution that mass volume ratio is 1.5%, standby；By the starch solution of preparation, cmc soln and gelatin solution by weight blended for 2:1:2, stir, prepare blended liquid, then blended liquid is filtered, vacuum deaerator, casting film-forming after standing, be drying to obtain absorbable hemostasia membrane material.
Embodiment 4:
Weighing 4g starch and be dissolved in deionized water, uniform stirring, to being completely dissolved, obtains the starch solution that mass volume ratio is 3.5%, standby；Weighing the carboxymethyl cellulose of 1.5g, heating is dissolved in deionized water, and uniform stirring, to being completely dissolved, obtains the cmc soln that mass volume ratio is 0.7%, standby；The gelatin weighing 2g is dissolved in deionized water, and 30 DEG C of heated and stirred, to being completely dissolved, obtain the gelatin solution that mass volume ratio is 1.5%, standby；By the starch solution of preparation, cmc soln and gelatin solution by weight blended for 3:1:1, stir, prepare blended liquid, then blended liquid is filtered, vacuum deaerator, casting film-forming after standing, be drying to obtain absorbable hemostasia membrane material.
Embodiment 5:
Weighing 4g starch and be dissolved in deionized water, uniform stirring, to being completely dissolved, obtains the starch solution that mass volume ratio is 3.5%, standby；Weighing the carboxymethyl cellulose of 1.5g, heating is dissolved in deionized water, and uniform stirring, to being completely dissolved, obtains the cmc soln that mass volume ratio is 0.7%, standby；The gelatin weighing 2g is dissolved in deionized water, and 30 DEG C of heated and stirred, to being completely dissolved, obtain the gelatin solution that mass volume ratio is 1.5%, standby；By the starch solution of preparation, cmc soln and gelatin solution by weight blended for 3:1:2, stir, prepare blended liquid, then blended liquid is filtered, vacuum deaerator, casting film-forming after standing, be drying to obtain absorbable hemostasia membrane material.
Embodiment 6:
Weighing 4g starch and be dissolved in deionized water, uniform stirring, to being completely dissolved, obtains the starch solution that mass volume ratio is 3.5%, standby；Weighing the carboxymethyl cellulose of 1.5g, heating is dissolved in deionized water, and uniform stirring, to being completely dissolved, obtains the cmc soln that mass volume ratio is 0.7%, standby；The gelatin weighing 2g is dissolved in deionized water, and 30 DEG C of heated and stirred, to being completely dissolved, obtain the gelatin solution that mass volume ratio is 1.5%, standby；By the starch solution of preparation, cmc soln and gelatin solution by weight blended for 4:2:3, stir, prepare blended liquid, then blended liquid is filtered, vacuum deaerator, casting film-forming after standing, be drying to obtain absorbable hemostasia membrane material.
Claims (4)
1. an absorbable hemostasia membrane material, it is characterised in that main component includes starch, carboxymethyl cellulose, gelatin；Described starch, carboxymethyl cellulose, gelatin weight ratio be (1～4): (1～2): (1～3).
2. the preparation method of absorbable hemostasia membrane material as claimed in claim 1, it is characterized in that, by the mode of blended under agitation by the starch solution of preparation, cmc soln, gelatin solution mix homogeneously, again blended liquid is carried out vacuum deaerator, casting film-forming after standing, is drying to obtain absorbable hemostasia film.
3. absorbable hemostasia membrane material preparation method as claimed in claim 2, it specifically comprises the following steps that
1) weighing a certain amount of starch and be dissolved in deionized water, uniform stirring is to being completely dissolved, and obtaining concentration is 0.5～5.0%(W/V) starch solution, standby；
2) weighing a certain amount of carboxymethyl cellulose and be dissolved in deionized water, uniform stirring is to being completely dissolved, and obtaining concentration is 0.5～0.7%(W/V) cmc soln, standby；
3) weighing a certain amount of gelatin and be dissolved in deionized water, 30 DEG C of heated and stirred are to being completely dissolved, and obtaining concentration is 0.5～1.5%(W/V) gelatin solution, standby；
4) by step 1), 2), 3) in the starch solution of preparation, cmc soln and gelatin solution by weight (1～4): (1～2): (1～3) is blended, prepare blended liquid, again blended liquid is filtered, vacuum deaerator, casting film-forming after standing, is drying to obtain absorbable hemostasia film.
4. absorbable hemostasia membrane material preparation method as claimed in claim 3, it is characterised in that described starch can be the one in carboxymethyl starch, hydroxypropyl starch, enzyme change starch, etherification starch etc..
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| CN201410748904.2A CN105727345A (en) | 2014-12-10 | 2014-12-10 | Absorbable hemostasis membrane material and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125792A (en) * | 2018-07-16 | 2019-01-04 | 广西民族大学 | A kind of cassava porous-starch hemostatic material and its preparation method and application |
| CN111346267A (en) * | 2020-04-14 | 2020-06-30 | 中国人民解放军海军军医大学第三附属医院 | Area can absorb antibiotic pancreas pipe drainage tube of hemostasis |
| WO2022018610A1 (en) | 2020-07-21 | 2022-01-27 | Ethicon, Inc. | Hemostatic composite aggregate materials having surface enriched with hemostasis-promoting agents |
| CN115873299A (en) * | 2022-11-10 | 2023-03-31 | 三亚中国农业大学研究院 | Porous cellulose/gelatin composite hemostatic aerogel and preparation method and application thereof |
-
2014
- 2014-12-10 CN CN201410748904.2A patent/CN105727345A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125792A (en) * | 2018-07-16 | 2019-01-04 | 广西民族大学 | A kind of cassava porous-starch hemostatic material and its preparation method and application |
| CN111346267A (en) * | 2020-04-14 | 2020-06-30 | 中国人民解放军海军军医大学第三附属医院 | Area can absorb antibiotic pancreas pipe drainage tube of hemostasis |
| WO2022018610A1 (en) | 2020-07-21 | 2022-01-27 | Ethicon, Inc. | Hemostatic composite aggregate materials having surface enriched with hemostasis-promoting agents |
| CN115873299A (en) * | 2022-11-10 | 2023-03-31 | 三亚中国农业大学研究院 | Porous cellulose/gelatin composite hemostatic aerogel and preparation method and application thereof |
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