CN104307031B - A kind of Preparation method and use of external preparation for skin repair materials - Google Patents
A kind of Preparation method and use of external preparation for skin repair materials Download PDFInfo
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- CN104307031B CN104307031B CN201410626693.5A CN201410626693A CN104307031B CN 104307031 B CN104307031 B CN 104307031B CN 201410626693 A CN201410626693 A CN 201410626693A CN 104307031 B CN104307031 B CN 104307031B
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Abstract
The invention discloses a kind of Preparation method and use of external preparation for skin repair materials, sodium alginate, polyvinyl alcohol and gelatin solution are mixed, add glutaraldehyde and the heating of glycerol mixed liquor is blended, then blended liquid carried out filter, vacuum deaerator, leave standstill and obtain this external preparation for skin repair materials.This external preparation for skin repair materials is applied to various traumatic wound surface, skin mucosa, empyrosis wound surface, the antibacterial anti hemorrhagic of operative incision etc., promotion organization healing.This external preparation for skin repair materials has good biocompatibility and biodegradability, and antibacterial, hemostasis, the short specific function such as more, the product of crosslinking curing is when contacting with wound surface, the growth of granulation tissue and the formation of epithelium can be accelerated, the disappearance and this product is degraded while organization healing, thus play the effect preventing hyperplastic tissue's adhesion.
Description
Technical field
The invention belongs to field of biomedical materials, be specifically related to a kind of Preparation method and use of external preparation for skin repair materials.
Background technology
Medical dressing is a class in order to cover the important medical material of skin ulcer wound or other damages, and their alternative impaired skin plays temporary barrier action, avoids or controls wound infection, providing the environment being beneficial to wound healing.Along with modern life rhythm is accelerated and the continuous growth of requirements of health care, the demand of medical dressing is also increasing year by year, especially has higher requirement to high performance functionality wound dressing.Combine dressing is paid much attention to as the application of modern medical dressing in recent years.
Gelatin is a kind of protein colloid, extracted by the skin of animal, bone, ligament, tendon and connective tissue thereof to obtain, it is the protein substance that there is water solublity He can congeal, odorless, tasteless, transparent or semitransparent crispy slice or powder, be widely used in industrial bonding agent, food product etc., be the main material of medicament capsule, suppository, wafer, plasma substitute in medical, also for tablet coating, gelfoam etc.
Alginic acid is also known as alginic acid, alginic acid, seaweeds, it is a kind of natural polysaccharide by monosaccharide aldehydic acid linear polymerization be present in Brown algae cell wall, its wide material sources, safety non-toxic, be widely used, when sodium alginate and calcium chloride generation ion exchange, be converted into the gel of stickiness while discharging calcium ion, there is the premium properties of the good compatibility, antiinflammatory, anti.
Polyvinyl alcohol has very high mechanical strength, good crystallinity, light transmission, hydrophilic, heat stability and chemical stability.Its aqueous solution is nonpoisonous and tasteless, has good biocompatibility, especially in medical treatment, repair dressing being widely used in ophthalmology, wound dressing and artificial joint as its aqueous.The mechanical performance of polyvinyl alcohol film is excellent, water white transparency, can natural decomposition in the short time at occurring in nature, pollution-free, is good environmental protection goods.
In sum, gelatin, alginic acid and polyvinyl alcohol all have respective premium properties, but performance is single, there is certain deficiency as medical dressing.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Preparation method and use of external preparation for skin repair materials.
For solving the problems of the technologies described above, preparation method of the present invention is mixed sodium alginate, polyvinyl alcohol and gelatin solution, adds glutaraldehyde and the heating of glycerol mixed liquor is blended, then carried out by blended liquid filtering, vacuum deaerator, leave standstill and get final product.
Preparation method of the present invention comprises the steps:
1) by alginic acid concentration be sodium hydroxide solution heating for dissolving under 45-55 DEG C of condition of 0.1mol/L, be mixed with the sodium alginate soln of mass percentage concentration at 5%-10%;
2) getting polyvinyl alcohol is dissolved in the water of 93-96 DEG C, and obtained mass percentage concentration is at the poly-vinyl alcohol solution of 5%-15%;
3) be added in water by gelatin, heated and stirred under 45-55 DEG C of condition, obtained mass percentage concentration is at the gelatin solution of 5%-15%;
4) by sodium alginate soln, poly-vinyl alcohol solution and gelatin solution be the ratio mixing of 1:1:1-3:3:1 by volume, and stir, obtained mixed solution;
5) by glutaraldehyde and glycerol according to volume ratio 1:1 mixing, its mixture is added in mixed solution prepared by step 4), blended 0.5-1h under 50-60 DEG C of condition, then blended liquid is carried out filter, vacuum deaerator, leaves standstill and get final product.
The mass volume ratio of mixed solution prepared by described glutaraldehyde and glycerol mixture and step 4) is 1:100-1:50g/ml.
Described sodium alginate soln is yellow emulsus.
This external preparation for skin repair materials is applied to various traumatic wound surface, skin mucosa, empyrosis wound surface, the antibacterial anti hemorrhagic of operative incision etc., promotion organization healing.
Tool of the present invention has the following advantages:
1) alginic acid has the biological activity such as good biocompatibility and antiinflammatory, anti, antibacterial and wound healing, can be degraded and absorbed, show good biodegradability, and about playing blood coagulation.
2) the inventive method cost of manufacture is low, due to raw materials used be alginic acid, polyvinyl alcohol and gelatin, cost is very low, makes external preparation for skin repair materials become possibility as a kind of conventional material.
3) easy to operate, the transparency of this external preparation for skin repair materials is good, good barrier property, wound healing, simultaneously soft, moistening gelinite provides wettability repairing environment for wound, accelerate the growth of granulation tissue and the formation of epithelium, thus make that this dressing is better than other similar dressing antibacterial effect, haemostatic effect is better, short more act on stronger.
4) preparation method of external preparation for skin repair materials of the present invention is simple, and material is easy to get, and is applicable to suitability for industrialized production, has a extensive future.
To sum up, this external preparation for skin repair materials has good biocompatibility and biodegradability, and antibacterial, hemostasis, the short specific function such as more, the product of crosslinking curing is when contacting with wound surface, the growth of granulation tissue and the formation of epithelium can be accelerated, the disappearance and this product is degraded while organization healing, thus play the effect preventing hyperplastic tissue's adhesion.
Detailed description of the invention
Embodiment 1
Taking 8g alginic acid is dissolved in the sodium hydroxide solution of 0.1mol/L, stir at 50 DEG C and be mixed with the sodium alginate soln that mass percentage concentration is 5%, getting 8g polyvinyl alcohol is dissolved in the hot water of 95 DEG C, obtain the poly-vinyl alcohol solution that mass percentage concentration is 5%, taking 8g gelatin is dissolved in 55 DEG C of water, stir, obtain the gelatin solution that mass percentage concentration is 5%.
The sodium alginate prepared, polyvinyl alcohol and gelatin solution are respectively got the mixing of 100ml sodium alginate, polyvinyl alcohol and gelatin solution according to the volume ratio of 1:1:1, add the mixed liquor that volume ratio is 1:1 glutaraldehyde and glycerol again, the amount of adding is 3g, at 50 DEG C of blended 1h, again blended liquid is carried out filtering, vacuum deaerator, leave standstill after, external preparation for skin repair materials can be obtained.This repair materials is gel, milky.
Embodiment 2:
Taking 20g alginic acid is dissolved in the sodium hydroxide solution of 0.1mol/L, stir at 55 DEG C and be mixed with the sodium alginate soln that mass percentage concentration is 8%, getting 20g polyvinyl alcohol is dissolved in the hot water of 93 DEG C, obtain the poly-vinyl alcohol solution that mass percentage concentration is 10%, taking 10g gelatin is dissolved in 45 DEG C of water, stir, obtain the gelatin solution that mass percentage concentration is 10%.
By the sodium alginate, polyvinyl alcohol and the gelatin solution that the prepare volume ratio according to 2:2:1, get the mixing of 160ml sodium alginate soln, 160ml poly-vinyl alcohol solution and 80ml gelatin solution, add the mixed liquor that volume ratio is 1:1 glutaraldehyde and glycerol again, the amount of adding is 5.3g, at 55 DEG C of blended 0.8h, again blended liquid is carried out filtering, vacuum deaerator, leave standstill after, external preparation for skin repair materials can be obtained.This repair materials is gel, milky.
Embodiment 3:
Taking 30g alginic acid is dissolved in the sodium hydroxide solution of 0.1mol/L, stir at 45 DEG C and be mixed with the sodium alginate soln that mass percentage concentration is 10%, getting 40g polyvinyl alcohol is dissolved in the hot water of 96 DEG C, obtain the poly-vinyl alcohol solution that mass percentage concentration is 15%, taking 15g gelatin is dissolved in 50 DEG C of water, stir, obtain the gelatin solution that mass percentage concentration is 15%.
By the sodium alginate, polyvinyl alcohol and the gelatin solution that the prepare volume ratio according to 3:3:1, get the mixing of 240ml sodium alginate soln, 240ml poly-vinyl alcohol solution and 80ml gelatin solution, add the mixed liquor that volume ratio is 1:1 glutaraldehyde and glycerol again, the amount of adding is 11.2g, at 60 DEG C of blended 0.5h, again blended liquid is carried out filtering, vacuum deaerator, leave standstill after, external preparation for skin repair materials can be obtained.This repair materials is gel, milky.
Claims (3)
1. a preparation method for external preparation for skin repair materials, is characterized in that comprising the steps:
1) by alginic acid concentration be sodium hydroxide solution heating for dissolving under 45-55 DEG C of condition of 0.1mol/L, be mixed with the sodium alginate soln of mass percentage concentration at 5%-10%;
2) getting polyvinyl alcohol is dissolved in the water of 93-96 DEG C, and obtained mass percentage concentration is at the poly-vinyl alcohol solution of 5%-15%;
3) be added in water by gelatin, heated and stirred under 45-55 DEG C of condition, obtained mass percentage concentration is at the gelatin solution of 5%-15%;
4) by sodium alginate soln, poly-vinyl alcohol solution and gelatin solution be the ratio mixing of 1:1:1-3:3:1 by volume, and stir, obtained mixed solution;
5) by glutaraldehyde and glycerol according to volume ratio 1:1 mixing, its mixture is added in mixed solution prepared by step 4), blended 0.5-1h under 50-60 DEG C of condition, then blended liquid is carried out filter, vacuum deaerator, leaves standstill and get final product.
2. the preparation method of external preparation for skin repair materials according to claim 1, is characterized in that the mass volume ratio of mixed solution prepared by described glutaraldehyde and glycerol mixture and step 4) is 1:100-1:50g/ml.
3. the preparation method of external preparation for skin repair materials according to claim 1, is characterized in that described sodium alginate soln is yellow emulsus.
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| CN201410626693.5A CN104307031B (en) | 2014-11-10 | 2014-11-10 | A kind of Preparation method and use of external preparation for skin repair materials |
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| CN201410626693.5A CN104307031B (en) | 2014-11-10 | 2014-11-10 | A kind of Preparation method and use of external preparation for skin repair materials |
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| CN104307031A CN104307031A (en) | 2015-01-28 |
| CN104307031B true CN104307031B (en) | 2015-12-30 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105561375B (en) * | 2016-01-05 | 2018-11-30 | 山东省药学科学院 | A kind of gelatin liquid-absorbent hemostatic sponge and preparation method thereof of dopamine crosslinking |
| CN105524956A (en) * | 2016-01-13 | 2016-04-27 | 山东贝诺医药生物科技有限公司 | Medical bacterial cellulose gel |
| CN108452366B (en) * | 2018-03-26 | 2021-08-13 | 中国海洋大学 | Cod skin gelatin composite hemostatic dressing and preparation method thereof |
| CN114949332B (en) * | 2022-04-15 | 2023-07-07 | 永康市第一人民医院 | Treating agent for rapidly promoting wound hemostasis and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5827840A (en) * | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
| CN103446621A (en) * | 2013-05-07 | 2013-12-18 | 哈尔滨工程大学 | Nano-silver-containing sodium alginate based antibacterial medical dressing and preparation method thereof |
| CN103520767A (en) * | 2013-10-28 | 2014-01-22 | 山东赛克赛斯药业科技有限公司 | Anti-microbial healing-promoting hydrogel dressing and preparation method therefor |
| CN104069535A (en) * | 2014-07-10 | 2014-10-01 | 山东贝诺医药生物科技有限公司 | Preparation method and application of bioactive composite film hemostasis dressing |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5827840A (en) * | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
| CN103446621A (en) * | 2013-05-07 | 2013-12-18 | 哈尔滨工程大学 | Nano-silver-containing sodium alginate based antibacterial medical dressing and preparation method thereof |
| CN103520767A (en) * | 2013-10-28 | 2014-01-22 | 山东赛克赛斯药业科技有限公司 | Anti-microbial healing-promoting hydrogel dressing and preparation method therefor |
| CN104069535A (en) * | 2014-07-10 | 2014-10-01 | 山东贝诺医药生物科技有限公司 | Preparation method and application of bioactive composite film hemostasis dressing |
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