CN105920661A - Absorbable wound buffering dressing - Google Patents
Absorbable wound buffering dressing Download PDFInfo
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- CN105920661A CN105920661A CN201610355375.9A CN201610355375A CN105920661A CN 105920661 A CN105920661 A CN 105920661A CN 201610355375 A CN201610355375 A CN 201610355375A CN 105920661 A CN105920661 A CN 105920661A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0031—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/009—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The invention belongs to the field of biological medicine materials, and particularly relates to an absorbable wound buffering dressing. The absorbable wound buffering dressing is formed by mixing plant crosslinked starch and body fluid. A preparation method for the absorbable wound buffering dressing comprises the steps that raw plant starch is dissolved in a water medium, and after the pH value is adjusted, by means of emulsification cross-linking reaction, extraction washing, drying and sterilization, plant crosslinked starch particles are obtained; the plant crosslinked starch particles and the body fluid are mixed fully, and the absorbable wound buffering dressing is obtained. The absorbable wound buffering dressing can play a role in protecting the wound and buffering the external force, is beneficial for wound healing, good in biocompatibility and easy and convenient to use, can directly act on an ordinary bleeding wound, a deep bleeding wound and a bleeding wound of a part which is hard to arrive in an operation, carry out degradation and absorption in a body and does not need to be removed out of the wound. Using is easy and convenient, and the absorbable wound buffering dressing has great significance in development of new biological medicine materials.
Description
Technical field
The invention belongs to biological medicine Material Field, be specifically related to a kind of absorbability wound buffering dressing.
Background technology
The dressing of wound, in its kind, has powder type dressing, foam type dressing, porous build dressing respectively
Or non-woven fabric type dressing etc., various dressing have its pluses and minuses respectively.In powder type dressing, its advantage is to make
Area big, therefore can cover on a large scale on wound, shortcoming is easily to form agglomerate, and is moving
Except upper more difficult removal.In foam type dressing, its advantage is the moistening degree of adjustable wound, to avoid wound
Mouth is injured by physical property, and shortcoming is to act only on the surface of wound, and its effect of wound for cavity type has
Limit.In porous build dressing, its advantage is absorbable substantial amounts of body fluid, it is to avoid wound inflammation festers, system
Making the healing environment of wet type, shortcoming is that structural strength is more weak, after moisture absorption swelling, will be unable to remove smoothly.
In non-woven fabric type dressing, its advantage is often to use biopolymer, has bio-compatibility, has wound
Promoting the effect of healing, after shortcoming is absorptive tissue liquid, fabric construction is destroyed, and is formed at wound and is stained with glutinous feelings
Shape, causes two degree of injuries；Medically for Wound protection, absorbing wound exudate body be usually the most common
The dressing such as gauze, such dressing does not possess promotion wound healing, and easily and the defect such as wound adhesion.
A kind of wound dressing of the patent disclosure of Application No. 201110458280.7, described wound dressing includes
Multiple hydrogel particles, each hydrogel particle be one present particle shape and have absorption liquid after dilatancy
The colloid of matter, described hydrogel particle adequately fills up wound；And one apply material, it covers on this wound,
To close described hydrogel particle in this wound.The patent disclosure of Application No. 201310224319.8 one
Planting wound covering thing, described wound covering thing comprises: a tissue layer, and described tissue layer is to be lived by polyacrylonitrile
Property carbon fiber braiding form, and its activated carbon fiber is that oxidized polyacrylonitrile fiber is at aqueous carbon dioxide gas
In body, maintain at 700 DEG C to 1200 DEG C and formed for 1 to 60 minute；One adsorption layer, be located at described in knit
Nitride layer is away from the side of described wound, and its material is super absorbent polymer, cotton, alginate, polyethylene
Alcohol, PU foam or a combination thereof；Described adsorption layer is higher than described tissue layer to the absorbability of water.Application number
Be a kind of wound dressing of patent disclosure of 200910115417.1, described wound dressing by medical hot melt adhesive and
Sodium carboxymethyl cellulose mixes, and described medical hot melt adhesive is medical poisonless, low irritability PUR,
Need after using to peel off from wound.
Above-mentioned wound dressing needs to remove carrier by one and remove from this wound after using, and has and cannot be applied to deeply
Portion's wound and operation technique are difficult to reach the wound that position is hemorrhage, and associated materials can not degradation in vivo absorb.
At present, the hemostatic material used clinically mainly has Fibrin Glue, collagen protein, gelfoam and fiber
Element hemostatic material, these materials all achieve good effect in zoopery and clinical practice, but the most all
Come with some shortcomings: its raw material sources of collagen, in animal tissue, are foreign proteins, rejection easily occur,
There is potential sensitization；Gelatin infiltration rate is slow, general more than 4 weeks, can increase the infection wind of wound
Danger；Cellulose family, human body lacks makes its enzyme degraded, and degradation time is long, may bring infection to patient
Deng side effect.
Starch is plant polysaccharide, its good biocompatibility, nontoxic, non-stimulated, be difficult to cause the mistake of body
Quick reaction, can be degraded to monosaccharide by the amylase in body fluid in vivo, and degradation in vivo absorbs.
At present, the relevant report of wound dressing with plant ative starch as raw material is had no.Therefore exploitation one can
Be applied to various wound and good biocompatibility, can the wound buffering dressing that absorbs of degradation in vivo for exploitation
New biological medicine material is significant.
Summary of the invention
In view of this, it is an object of the invention to provide a kind of absorbability wound buffering dressing, this can absorb
Property wound buffering dressing wound can be played protection and buffering external force effect, absorbability wound in the present invention
Buffering dressing good biocompatibility, can be done directly on general bleeding wounds, Hemorrhage in Deep wound and operation behaviour
Make unapproachable position bleeding wounds, easy to use, can degradation in vivo absorb, after using without
Remove from wound.
For achieving the above object, the technical scheme is that
The buffering dressing of absorbability wound, the buffering dressing of described absorbability wound is by plant crosslinked starch and body
Liquid is mixed to form.
Described body fluid includes interstitial fluid, blood, blood plasma.
The buffering dressing of described absorbability wound is protected and in addition to the effect of buffering external force except playing wound,
Medicine can also be made to wound from absorbability wound buffering dressing slow release as the carrier of medicine, accelerates wound
Face is repaired, and reduces wound infection, improves cure rate, shortens the course of disease, alleviates patient suffering.
Further, described plant crosslinked starch is 10:10-200 with the weight ratio of body fluid.
Preferred as one, described plant crosslinked starch is 10:50-150 with the weight ratio of body fluid.
The weight ratio of plant crosslinked starch and body fluid in the range of 10:10-200, the absorbability prepared
Wound buffering dressing is flexible glue shape, freely deformable and be difficult to dispersion, easily applies in wound, viscous to tissue
Attached power is strong, can continue to draw the body fluid that wound is oozed out, protect while protection wound and buffering wound external force
Protect wound, exempt the antibacterial intrusion to wound, it is to avoid wound inflammation festers, provide good healing for wound
Environment.If plant crosslinked starch excess, the absorbability wound prepared on this proportional basis
Buffering dressing is harder colloid, it is impossible to arbitrary deformation is less susceptible to apply in wound, weak to bioadhesion,
It is difficult to apply in wound；If body fluid excess, the then absorbability prepared on this proportional basis
Wound buffering dressing is diluter glue, applies and can flow at wound, it is difficult to reach to protect the purpose of wound.
Further, described plant crosslinked starch is that plant ative starch prepares through emulsification and cross linked reaction, described plant
Ative starch includes potato starch, corn starch, one or more of sweet potato starch and wheaten starch.
Plant crosslinked starch is plant polysaccharide, its good biocompatibility, nontoxic, non-stimulated, be difficult to cause
The anaphylaxis of body, can be degraded to monosaccharide by the amylase in body fluid in vivo, and degradation in vivo absorbs.
The two of the purpose of the present invention are to provide the preparation method of a kind of absorbability wound buffering dressing, including
Following steps:
1) take described plant ative starch to be dissolved in aqueous medium, after regulation pH value, through emulsification and cross linked reaction, take out
Propose washing, dry sterilization obtains plant crosslinked starch microgranule；
2) by step 1) described in plant crosslinked starch microgranule be sufficiently mixed with body fluid, obtain absorbability wound
Buffering dressing.
The buffering dressing of described absorbability wound is gluey, easily applies in wound, and plant therein crosslinking is formed sediment
The micropore of powder microparticle surfaces plays molecular sieve effect, has strong absorptive, can in moment draw body fluid body fluid
Moisture, such as the visible component (such as: thrombin, platelet, fibrin, erythrocyte etc.) in blood
And/or the visible component (such as: plasma protein etc.) in blood plasma is gathered in particle surface, produce " instant gel ".
Meanwhile, platelet, thrombin and fibrinous local concentration raise significantly, start activation simultaneously
And strengthen intrinsic coagulation mechanism, play machine plugging blood vessel cut effect.Described absorbability is hindered
Mouth buffering dressing can continue, while protection wound and buffering wound external force, the body fluid that absorption wound is oozed out,
Avoid wound inflammation to fester, Moist healing environment is provided in wound, maintains the hypoxia of wound surface local microenvironment
The dissolving of state, beneficially slough and the proliferation and differentiation of cell, create the healing environment close to physiological status.
The buffering dressing of described absorbability wound may be used on traumatic hemorrhage, and surgical operation wound surface is hemorrhage, oozing of blood,
Hemorrhage in Deep and operation technique are difficult to reach the wound that position is hemorrhage, and it can degradation in vivo absorb, biological
The compatibility is good, nontoxic, non-stimulated, be difficult to cause the anaphylaxis of body and bring the side effect such as infection.
Further, step 1) particle diameter of described plant crosslinked starch microgranule is 30-200um.
Further, step 1) described regulation pH value is pH9-10.
Further, step 1) described emulsification and cross linked reaction in emulsifying agent include Span 80 and liquid paraffin, institute
The weight ratio stating liquid paraffin and Span 80 is 0.5-45:0.5-2；Described emulsifying agent and the weight of plant ative starch
Ratio is 0.5-150:1.
Emulsifying agent is to improve the various surface tension constituted between phase in emulsion, is allowed to be formed the most surely
Fixed dispersion or the material of emulsion.Although chemical reaction the most directly participated in by emulsifying agent, but its consumption meeting
Affect the quantity of emulsion particle, size and distribution in emulsification system, thus determine final plant ative starch microgranule
Diameter and particle diameter distribution.
Further, step 1) cross-linking agent is epoxychloropropane in the reaction of described emulsification and cross linked, described epoxy chloropropionate
Alkane is 0.01-0.2:1 with the weight ratio of described plant ative starch.
Cross-linking agent is that one can be at intermolecular bridging action of line style, so that the mutual key of multiple linear molecule
Conjunction is cross-linked into cancellated material, promotes or regulate what polymer molecule interchain covalent bond or ionic bond were formed
Material.The swelling behavior of the consumption impact regulation cross-linked polymer particle of cross-linking agent, swelling behavior includes swelling
Size and swelling rate.
Further, step 1) in reaction time mixing speed be 100-500rpm；The temperature of described reaction is 40
-70℃。
The quality of absorbability wound buffering dressing is also had a significant impact by mixing speed and temperature, mixing speed
The absorbability wound buffering dressing formed in the range of 100-500rpm is homogeneous, freely deformable and be difficult to point
Dissipate, easily apply in wound, strong to bioadhesion；The following is different mixing speed and be prepared by different temperatures
The quality of the absorbability wound buffering dressing obtained:
As the relatively low 0-100rpm of mixing speed, it is impossible to make emulsifying agent be sufficiently mixed with reaction mass and cross-linking agent,
Causing reaction inequality, cross-linking effect is poor；
As the too high 500-1000rpm of mixing speed, it is easily caused the structure after crosslinking and is broken, thus lose
Loose structure, the most easily produces less granule, thus reduces product quality.
Preferred as one, described preparation method, comprise the following steps:
1) take plant ative starch to be dissolved in aqueous medium, 50 ± 5 DEG C of stirring 20min, after stirring, regulate pH extremely
9-10, prepares starch suspension；
2) taking Span 80 by above-mentioned weight ratio to be dissolved in liquid paraffin, stir 20min, prepared mixing and emulsifying divides
Powder, is subsequently adding starch suspension, stirs 20min, prepares starch emulsion；
3) take epoxychloropropane to be dissolved in aqueous medium, be subsequently adding in starch emulsion, stirring crosslinking 3h, stirs
Mixing speed is 100-500rpm, and temperature is 40-70 DEG C, prepares crosslinked fluid；
4) by crosslinked fluid stratification, abandon supernatant, in lower floor's milky white liquid, add ethyl acetate stirring all
After even, stratification, take off layer milky white liquid and add an absolute ethanol washing, stratification after stirring,
Abandoning supernatant, lower floor's milky white liquid vacuum is drained, and obtains solid particle；
5) prepared solid particle is dissolved in aqueous medium, magnetic agitation, then stratification, abandon supernatant, take
Lower floor's milky white liquid, repeated washing 3-5 time, the milky white liquid finally obtained is dried, sterilizing, thus obtaining the product is planted
Thing crosslinked starch microgranule；
6) by step 5) described in plant crosslinked starch microgranule be sufficiently mixed with body fluid according to the above ratio, can
Absorbent wound buffering dressing.
The present invention also aims to provide a kind of plant ative starch in preparation absorbability wound buffering dressing side
The application in face.
Described wound includes traumatic hemorrhage, and surgical operation wound surface is hemorrhage, oozing of blood, Hemorrhage in Deep and operation technique
It is difficult to reach the wound that position is hemorrhage.
The beneficial effects of the present invention is:
1) wound can be played protection and the work of buffering external force by the absorbability wound buffering dressing that the present invention provides
With, beneficially wound healing, the biological medicine material new for exploitation is significant；
2) dressing of absorbability wound buffering can provide Moist healing environment in wound, maintains wound surface local micro-
The dissolving of the hypoxia of environment, beneficially slough and the proliferation and differentiation of cell, create close to physiological status
Healing environment；
3) dressing of described absorbability wound buffering has a good biocompatibility, nontoxic, non-stimulated, be difficult to
Cause the anaphylaxis of body, monosaccharide degradation in vivo can be degraded to by the amylase in body fluid in vivo and absorb,
Without removing from wound after using；
4) dressing of described absorbability wound buffering can be done directly on general bleeding wounds, Hemorrhage in Deep wound
And operation technique unapproachable position bleeding wounds, easy to use, low cost；
5) dressing of described absorbability wound buffering is flexible glue shape, easily applies in wound, and plant therein is former
The micropore on starch microparticles surface plays molecular sieve effect, has strong absorptive, and described absorbability wound buffers
Dressing can continue to draw the body fluid that wound is oozed out, protection wound while protection wound and buffering wound external force
Mouthful, exempt the antibacterial intrusion to wound, it is to avoid wound inflammation festers, provide good healing environment for wound.
Detailed description of the invention
Hereinafter detailed description of a preferred embodiment of the present invention will be given.Unreceipted concrete bar in preferred embodiment
The experimental technique of part, generally according to normal condition, illustrated embodiment is in order to preferably to present disclosure
Illustrate, but be not that present disclosure is only limitted to illustrated embodiment.So being familiar with the technology of this area
Personnel carry out nonessential improvement and adjustment according to foregoing invention content to embodiment, still fall within the present invention's
Protection domain.
The buffering dressing of embodiment 1 absorbability wound
The buffering dressing of absorbability wound, the buffering dressing of described absorbability wound is by plant crosslinked starch and body
Liquid is mixed to form, and described plant crosslinked starch is 10:100 with the weight ratio of body fluid.
The buffering dressing of embodiment 2 absorbability wound
The buffering dressing of absorbability wound, the buffering dressing of described absorbability wound is by plant crosslinked starch and body
Liquid is mixed to form, and described plant crosslinked starch is 10:120 with the weight ratio of body fluid.
The preparation method of embodiment 3 absorbability wound buffering dressing
Proportioning according to embodiment 1 prepares the buffering dressing of absorbability wound, comprises the following steps:
1) take 20g potato starch to be dissolved in 300ml distilled water, after stirring, regulate pH with sodium hydroxide
To 9-10, prepare starch suspension；
2) take 4g Span 80 to be dissolved in 50ml liquid paraffin, stir 20min, prepare mixing and emulsifying dispersant,
It is subsequently adding starch suspension, stirs 20min, prepare starch emulsion；
3) take 0.1g epoxychloropropane to be dissolved in distilled water, be subsequently adding in starch emulsion, stirring crosslinking 5h,
Mixing speed is 100rpm, and temperature is 40 DEG C, prepares crosslinked fluid；
4) by crosslinked fluid stratification, abandon supernatant, in lower floor's milky white liquid, add the acetic acid of 8 times of volumes
After ethyl ester stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 4 times of volumes,
Stratification after stirring, abandons supernatant, and lower floor's milky white liquid vacuum is drained, and obtains solid particle；
5) prepared solid particle is dissolved in the distilled water of 3 times of volumes, magnetic agitation, then stratification,
Abandon supernatant, take off a layer milky white liquid, repeated washing 4 times, the milky white liquid finally obtained is dried, goes out
Bacterium i.e. obtains plant crosslinked starch microgranule；
6) by step 5) described in plant crosslinked starch microgranule be sufficiently mixed with body fluid according to the above ratio, can
Absorbent wound buffering dressing.
Prepare absorbability wound buffering dressing be flexible glue shape, freely deformable and be difficult to dispersion, hold
Easily apply in wound, strong to bioadhesion, can continue to inhale while protection wound and buffering wound external force
Take the body fluid that wound is oozed out, protect wound, exempt the antibacterial intrusion to wound, it is to avoid wound inflammation festers,
Good healing environment is provided for wound.
The preparation method of embodiment 4 absorbability wound buffering dressing
Proportioning according to embodiment 2 prepares the buffering dressing of absorbability wound, comprises the following steps:
1) take 15g sweet potato starch to be dissolved in 300ml distilled water, after stirring with sodium hydroxide regulation pH extremely
9-10, prepares starch suspension；
2) take 4g Span 80 to be dissolved in 80ml liquid paraffin, stir 20min, prepare mixing and emulsifying dispersant,
It is subsequently adding starch suspension, stirs 20min, prepare starch emulsion；
3) take 0.2g epoxychloropropane to be dissolved in distilled water, be subsequently adding in starch emulsion, stirring crosslinking 3h,
Mixing speed is 200rpm, and temperature is 45 DEG C, prepares crosslinked fluid；
4) by crosslinked fluid stratification, abandon supernatant, in lower floor's milky white liquid, add the acetic acid of 5 times of volumes
After ethyl ester stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 3 times of volumes,
Stratification after stirring, abandons supernatant, and lower floor's milky white liquid vacuum is drained, and obtains solid particle；
5) prepared solid particle is dissolved in the distilled water of 5 times of volumes, magnetic agitation, then stratification,
Abandon supernatant, take off a layer milky white liquid, repeated washing 3 times, the milky white liquid finally obtained is dried, goes out
Bacterium i.e. obtains plant crosslinked starch microgranule；
6) by step 5) described in plant crosslinked starch microgranule be sufficiently mixed with body fluid according to the above ratio, can
Absorbent wound buffering dressing.
Prepare absorbability wound buffering dressing be flexible glue shape, freely deformable and be difficult to dispersion, hold
Easily apply in wound, strong to bioadhesion, can continue to inhale while protection wound and buffering wound external force
Take the body fluid that wound is oozed out, protect wound, exempt the antibacterial intrusion to wound, it is to avoid wound inflammation festers,
Good healing environment is provided for wound.
Comparative example 1
Absorbability wound buffering is prepared by the formula that weight ratio is 50:50 of Crosslinked Potato Starch Yu body fluid
Dressing, comprises the following steps:
1) take 15g potato starch to be dissolved in 300ml distilled water, regulate with sodium hydroxide after stirring
PH to 9-10, prepares starch suspension；
2) take 4g Span 80 to be dissolved in 80ml liquid paraffin, stir 20min, prepare mixing and emulsifying dispersion
Agent, is subsequently adding starch suspension, stirs 20min, prepares starch emulsion；
3) take 0.2g epoxychloropropane to be dissolved in distilled water, be subsequently adding in starch emulsion, stirring crosslinking 3h,
Mixing speed is 200rpm, and temperature is 45 DEG C, prepares crosslinked fluid；
4) by crosslinked fluid stratification, abandon supernatant, in lower floor's milky white liquid, add the acetic acid of 5 times of volumes
After ethyl ester stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 3 times of volumes,
Stratification after stirring, abandons supernatant, and lower floor's milky white liquid vacuum is drained, and obtains solid particle；
5) prepared solid particle is dissolved in the distilled water of 5 times of volumes, magnetic agitation, then stratification,
Abandon supernatant, take off a layer milky white liquid, repeated washing 3 times, the milky white liquid finally obtained is dried, goes out
Bacterium i.e. obtains plant crosslinked starch microgranule；
6) by step 5) described in plant crosslinked starch microgranule be sufficiently mixed with body fluid according to the above ratio, can
Absorbent wound buffering dressing.
The absorbability wound buffering dressing taking comparative example 1 and embodiment 2 preparation does bioadhesion mensuration
Experiment, experimental result finds, the absorbability wound buffering dressing of preparation in embodiment 2 is bright to bioadhesion
The adhesion (p ＜ 0.05) of the aobvious absorbability wound buffering dressing higher than comparative example 1 preparation.
The absorbability wound buffering dressing prepared is harder colloid, it is impossible to arbitrary deformation is less susceptible to apply
In wound, weak to bioadhesion, it is difficult to apply in wound.
Comparative example 2
Absorbability wound buffering is prepared by the formula that weight ratio is 2:120 of Crosslinked Potato Starch Yu body fluid
Dressing, comprises the following steps:
1) take 15g potato starch to be dissolved in 300ml distilled water, regulate with sodium hydroxide after stirring
PH to 9-10, prepares starch suspension；
2) take 4g Span 80 to be dissolved in 80ml liquid paraffin, stir 20min, prepare mixing and emulsifying dispersion
Agent, is subsequently adding starch suspension, stirs 20min, prepares starch emulsion；
3) take 0.2g epoxychloropropane to be dissolved in distilled water, be subsequently adding in starch emulsion, stirring crosslinking 3h,
Mixing speed is 200rpm, and temperature is 45 DEG C, prepares crosslinked fluid；
4) by crosslinked fluid stratification, abandon supernatant, in lower floor's milky white liquid, add the acetic acid of 5 times of volumes
After ethyl ester stirs, stratification, take off layer milky white liquid and add the absolute ethanol washing of 3 times of volumes,
Stratification after stirring, abandons supernatant, and lower floor's milky white liquid vacuum is drained, and obtains solid particle；
5) prepared solid particle is dissolved in the distilled water of 5 times of volumes, magnetic agitation, then stratification,
Abandon supernatant, take off a layer milky white liquid, repeated washing 3-5 time, the milky white liquid finally obtained is dried,
Sterilizing, thus obtaining the product plant crosslinked starch microgranule；
6) by step 5) described in plant crosslinked starch microgranule be sufficiently mixed with body fluid according to the above ratio, can
Absorbent wound buffering dressing.
The absorbability wound buffering dressing taking comparative example 2 and embodiment 2 preparation does bioadhesion mensuration
Experiment, experimental result finds, the absorbability wound buffering dressing of preparation in embodiment 2 is bright to bioadhesion
The adhesion (p ＜ 0.05) of the aobvious absorbability wound buffering dressing higher than comparative example 2 preparation.
The absorbability wound buffering dressing prepared is diluter glue, applies and can flow at wound, it is difficult to
Reach to protect the purpose of wound.
The buffering dressing of embodiment 5 absorbability wound processes femoral artery bleeding wounds
Experimental technique: healthy rabbits 18, male and female dual-purpose, body weight 2.0-3.0kg, causes the hemorrhage wound of femoral artery
Mouth die type, sewing-up cut, it is randomly divided into 2 groups, often group 9.It is grouped as follows: 1. model group, uses common
The dressing such as gauze, hemostasis by compression 10 minutes, need to remove from wound after using；2. by reagent group, use can be inhaled
The property received wound buffering dressing, presses 3 minutes.Each group is used for detecting solidifying in experiment foreneck total arterial blood extracting 2.0ml
Blood function, index includes: PT (prothrombin time), APTT (partial thromboplastin time), PT-INR
International standard ratio, Fib: Fibrinogen, TT thrombin time.1week after experiment, 2week,
3week, 4week common carotid artery takes blood 2.0ml and carries out coagulation function detection, and index ibid, and observes animal
General status such as body weight change, wound local response and healing situation.Data process: use GraphPad Prism
6.0 softwares carry out data analysis, and data are usedRepresent, t inspection, P ＜ 0.05 table between sample employing group
Bright difference is statistically significant.
Experimental result:
1. the absorbability wound buffering dressing impact on coagulation function: compared with model group, by reagent group pair
Coagulation function is without impact (p ＞ 0.05).
2. the absorbability wound buffering dressing impact on Rabbit Femoral Artery bleeding wounds amount of bleeding: model group is hindered
Stomatorrhagia amount is apparently higher than by reagent group (p** ＜ 0.01).
3. the absorbability wound buffering dressing impact on Rabbit Femoral Artery bleeding wounds healing state:
The dressing healing of absorbability wound buffering wants fast compared with model group, and healing state is good.By reagent group
In postoperative 3 days, wound surface is red and swollen, one week, red and swollen disappearance, and wound starts healing.Heal completely after 2 weeks, have no
Suppurating and infect, healed surface is smooth, without hyperplasia.
4. the absorbability wound buffering dressing impact on femoral artery bleeding wounds rabbit ordinary circumstance: Post operation 3
In it, animal general status is good, and fur is smooth.Body weight compares no significant difference (p ＞ 0.05 between respectively organizing.).
Experiment conclusion: the buffering dressing of absorbability wound has protection wound and subtracts Rabbit Femoral Artery bleeding wounds
The little effect with buffering external impacts, beneficially wound healing, can obviously reduce wound Continuous hemorrhage, and right
Wound healing, without impact, is also had no adverse effects, also has no adverse effects the general state of animal by coagulation function,
Illustrate that wound effectively can be played protection and buffering External Force Acting by the buffering dressing of absorbability wound, prevent and continue
Hemorrhage, beneficially wound healing, and there is good safety.
The buffering dressing of embodiment 6 absorbability wound processes liver surface bleeding wounds
Experimental technique: healthy rabbits 18, male and female dual-purpose, body weight 2.0-3.0kg, makes on animal livers surface
1.5 × 1.5cm, the wound surface of degree of depth 0.2cm, causes hepatorrhagia wound model, is randomly divided into 2 groups, often group 9.
It is grouped as follows: 1. model group, uses the dressing such as common gauze, hemostasis by compression 10 minutes, need to be from wound after using
Mouth sews up abdominal cavity after removing；2. by reagent group, stitch after using the buffering dressing of absorbability wound and pressing 3 minutes
Close abdominal cavity.
Each group is used for detecting hemorheology index in experiment foreneck total arterial blood extracting 3.0ml, and index includes: complete
Blood viscosity undercut (mpas1, mpas3, mpas30, mpas50, mpas200), blood viscosity (XJND).
Take blood 3.0ml in Post operation 2day, 1week, 2week, 4week common carotid artery and carry out Hemorheology detection,
Index ibid, and observes general status such as body weight change, wound local response and the healing situation of animal.Number
According to process: using GraphPad Prism 6.0 software to carry out data analysis, data are usedRepresent, sample
T inspection between this employing group, P ＜ 0.05 shows that difference is statistically significant.
Experimental result:
1. the dressing of absorbability wound buffering is on the hepatorrhagia rheol impact of wound rabbit blood: cause liver
After hemorrhage, model group gauze pressing haemostatic needs 10 minutes；The buffering dressing of absorbability wound is used by reagent group
And can stop blooding after pressing 3 minutes.Compared with model group, reduced (p by the blood viscosity of reagent group 2day after surgery
＜ 0.01, p ＜ 0.05), and model group blood viscosity raises (p ＜ 0.01), illustrates that 2 days blood of hepatic injury glues
Degree is to increase, and this contributes to hemostasis, and is not increased blood viscosity by the hemostasis of reagent group, and this can be avoided
The thrombotic risk increased by blood viscosity and cause.
2. the absorbability wound buffering dressing impact on Rabbit Liver wound surface amount of bleeding: model group hepatorrhagia wound
Amount of bleeding is apparently higher than by reagent group (p* ＜ 0.05).
3. the absorbability wound buffering dressing impact on hepatorrhagia wound rabbit wound healing situation: with model
Group is compared the buffering dressing healing of absorbability wound and is wanted fast, and healing state is good.In postoperative 3 days, wound surface is red and swollen,
One week, red and swollen disappearance, wound started healing.Healing completely after 2 weeks, have no suppuration and infect, healed surface is put down
Whole, without hyperplasia, illustrate by reagent, the healing of wound to be had no adverse effects.
4. the absorbability wound buffering dressing impact on hepatorrhagia wound rabbit ordinary circumstance: Post operation is in 3 days,
Animal general status is not good enough, and fur owes smooth.After 1 week, general status is good, and fur brilliance, between each group of body weight
Relatively no significant difference (p ＞ 0.05.), one week body weight of hepatic injury has respectively organized reduction, model group (##p ＜
0.01), by reagent group (#p ＜ 0.05)；After hepatic injury 3 weeks, each group body weight has notable model of growth group 3
Week (#p ＜ 0.05), 4 weeks (##p ＜ 0.01)；, by reagent group 3 weeks (#p ＜ 0.05), 4 weeks (##p ＜ 0.01).
Experiment conclusion: the buffering dressing of absorbability wound has protection wound and subtracts Rabbit Liver bleeding due to trauma wound
The little effect with buffering external impacts, beneficially wound healing, can obviously reduce wound Continuous hemorrhage, to blood
Fluid rheology has no adverse effects, and the reaction that also can reduce the blood viscosity caused by bleeding lesions is increased and hyperamization
The risk that bolt is formed, to the recovery after hepatic injury, also has no adverse effects, has good safety.Explanation
Wound effectively can be played protection and buffering External Force Acting by the buffering dressing of absorbability wound, prevents Continuous hemorrhage,
It is beneficial to wound healing, and there is good safety.
The buffering dressing of embodiment 7 absorbability wound processes liver surface bleeding wounds as pharmaceutical carrier
Experimental technique: healthy rabbits 18, male and female dual-purpose, body weight 2.0-3.0kg, makes on animal livers surface
1.5 × 1.5cm, the wound surface of degree of depth 0.2cm, causes hepatorrhagia wound model, is randomly divided into 2 groups, often group 9.
It is grouped as follows: 1. model group, uses the dressing such as common gauze, hemostasis by compression 10 minutes, need to be from wound after using
Mouth sews up abdominal cavity after removing；2. by reagent group, stitch after using the buffering dressing of absorbability wound and pressing 3 minutes
Close abdominal cavity；3. slow releasing pharmaceutical group, uses and with the addition of the buffering dressing of penicillin absorbability wound and press 3 minutes
Rear stitching abdominal cavity.
Each group is used for detecting hemorheology index in experiment foreneck total arterial blood extracting 3.0ml, and index includes: complete
Blood viscosity undercut (mpas1, mpas3, mpas30, mpas50, mpas200), blood viscosity (XJND).
Take blood 3.0ml in Post operation 2day, 1week, 2week, 4week common carotid artery and carry out Hemorheology detection,
Index ibid, and observes general status such as body weight change, wound local response and the healing situation of animal.Number
According to process: using GraphPad Prism 6.0 software to carry out data analysis, data are usedRepresent, sample
T inspection between this employing group, P ＜ 0.05 shows that difference is statistically significant.
Experimental result:
1. the dressing of absorbability wound buffering is on the hepatorrhagia rheol impact of wound rabbit blood: cause liver
After hemorrhage, model group gauze pressing haemostatic needs 10 minutes；Absorbability is used by reagent group and slow releasing pharmaceutical group
Wound can stop blooding after buffering dressing and pressing 3 minutes.Compared with model group, existed by reagent group and slow releasing pharmaceutical group
The blood viscosity of postoperative 2day reduces (p ＜ 0.01, p ＜ 0.05), and model group blood viscosity raises (p ＜ 0.01),
Illustrating what 2 days blood viscositys of hepatic injury were to increase, this contributes to hemostasis, and by reagent group and and slow releasing pharmaceutical group
Stop blooding and do not increase blood viscosity, this thrombotic risk can avoided being increased by blood viscosity and cause.
2. the absorbability wound buffering dressing impact on Rabbit Liver wound surface amount of bleeding: model group hepatorrhagia wound
Amount of bleeding is apparently higher than by reagent group (p* ＜ 0.05), and test medicine group and slow releasing pharmaceutical group amount of bleeding are without aobvious
Write difference (p ＞ 0.05).
3. the absorbability wound buffering dressing impact on hepatorrhagia wound rabbit wound healing situation: with model
Group is compared the buffering dressing healing of absorbability wound and is wanted fast, and healing state is good；In postoperative 3 days, wound surface is red and swollen,
One week, red and swollen disappearance, wound started healing.Healing completely after 2 weeks, have no suppuration and infect, healed surface is put down
Whole, without hyperplasia, illustrate by reagent, the healing of wound to be had no adverse effects.Slow releasing pharmaceutical group with by reagent
Thing group is compared healing and is wanted fast, and healing state is good.In postoperative 3 days, wound surface is red and swollen, 5 days, red and swollen disappearance, wound
Mouth starts healing.Healing completely after 10 days, have no suppuration and infect, healed surface is smooth, without hyperplasia,
Illustrate that the healing of wound is had no adverse effects by slow releasing pharmaceutical group.
Experiment conclusion: reagent thing group and slow releasing pharmaceutical group have protection wound and subtract Rabbit Liver bleeding due to trauma wound
The little effect with buffering external impacts, beneficially wound healing, can obviously reduce wound Continuous hemorrhage, to blood
Fluid rheology has no adverse effects, and the reaction that also can reduce the blood viscosity caused by bleeding lesions is increased and hyperamization
The risk that bolt is formed, to the recovery after hepatic injury, also has no adverse effects, has good safety.Explanation
Wound effectively can be played protection and buffering External Force Acting by the buffering dressing of absorbability wound, prevents Continuous hemorrhage,
It is beneficial to wound healing, and there is good safety.But slow releasing pharmaceutical healing rate is very fast, healing state ratio
Reagent thing group to be got well, and illustrates that absorbability wound buffering applies the carrier as medicine, makes medicine from absorbability
Wound buffering dressing slow release, to wound, accelerates wound repair, reduces wound infection, improves cure rate, contracting
The short course of disease, alleviates patient suffering.
The embodiment 8 absorbability wound buffering dressing mensuration to bioadhesion
Experimental technique: packet and method are shown in embodiment 5, observes wound bleeding and really stops, slowly after 15min
Pressure relief, draws haemostatic membrane the most vertically upward and (connects single line in the center of nylon wire in advance, use
In connecting tonotransducer, model group traction gauze), calculate adhesion with maximum drawbar pull crest.
Experimental result: absorbability wound buffering dressing wound surface hemorrhage to Rabbit Femoral Artery local organization adhesion:
By the bioadhesion of reagent group apparently higher than the adhesion (p ＜ 0.05) of model group.
Conclusion: absorbability wound buffering dressing wound surface hemorrhage to Rabbit Femoral Artery local organization has the most viscous
Attached power, effectively can play protection and buffering External Force Acting, prevent Continuous hemorrhage, beneficially wound healing wound,
And there is good safety.
Finally illustrate, above example only in order to technical scheme to be described and unrestricted, although
With reference to preferred embodiment, the present invention is described in detail, it will be understood by those within the art that,
Technical scheme can be modified or equivalent, without deviating from technical solution of the present invention
Objective and scope, it all should be contained in the middle of scope of the presently claimed invention.
Claims (10)
1. absorbability wound buffering dressing, it is characterised in that the buffering dressing of described absorbability wound is handed over by plant
Connection starch and body fluid are mixed to form.
Absorbability wound the most according to claim 1 buffering dressing, it is characterised in that described plant cross-links
Starch is 1-9:10-200 with the weight ratio of body fluid.
Absorbability wound the most according to claim 1 buffering dressing, it is characterised in that described plant cross-links
Starch is that plant ative starch prepares through emulsification and cross linked reaction, and described plant ative starch includes potato starch,
Corn starch, one or more of sweet potato starch and wheaten starch.
4. the preparation method of absorbability wound buffering dressing described in any one of claim 1-3, it is characterised in that
Comprise the following steps:
1) take described plant ative starch to be dissolved in aqueous medium, after regulation pH value, through emulsification and cross linked reaction, extracting
Washing, dry sterilization obtain plant crosslinked starch microgranule；
2) by step 1) described in plant crosslinked starch microgranule be sufficiently mixed with body fluid, obtain absorbability wound delay
Rush dressing.
Preparation method the most according to claim 4, it is characterised in that step 1) described plant crosslinked starch
The particle diameter of microgranule is 30-200um.
Preparation method the most according to claim 4, it is characterised in that step 1) described regulation pH value is
pH9-10。
Preparation method the most according to claim 4, it is characterised in that step 1) reaction of described emulsification and cross linked
In emulsifying agent include that Span 80 and liquid paraffin, described liquid paraffin with the weight ratio of Span 80 are
0.5-45:0.5-2；Described emulsifying agent is 0.5-150:1 with the weight ratio of plant ative starch.
Preparation method the most according to claim 4, it is characterised in that step 1) reaction of described emulsification and cross linked
Middle cross-linking agent is epoxychloropropane, and described epoxychloropropane with the weight ratio of described plant ative starch is
0.01-0.2:1。
Preparation method the most according to claim 4, it is characterised in that step 1) in reaction time stirring speed
Degree is 100-500rpm；The temperature of described reaction is 40-70 DEG C.
10. plant crosslinked starch application in terms of preparation absorbability wound buffering dressing.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421865A (en) * | 2016-07-29 | 2017-02-22 | 江苏蓝湾生物科技有限公司 | Preparation method of collagen-based dressing with self anti-inflammatory function |
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