CN108686103A - A kind of hemostatic traditional Chinese medicine composition and multifunctional emergency stop blooding composite material - Google Patents
A kind of hemostatic traditional Chinese medicine composition and multifunctional emergency stop blooding composite material Download PDFInfo
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- CN108686103A CN108686103A CN201810988096.5A CN201810988096A CN108686103A CN 108686103 A CN108686103 A CN 108686103A CN 201810988096 A CN201810988096 A CN 201810988096A CN 108686103 A CN108686103 A CN 108686103A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The invention discloses a kind of hemostatic traditional Chinese medicine composition and multifunctional emergency hemostasis composite materials, which includes that following raw material medicine is prepared:20-40 parts of bletilla, 20-40 parts of hairyvein agrimony, 5-15 parts of cattail pollen, 20-40 parts of Radix Notoginseng, 10-30 parts of Paris polyphylla, 10-30 parts of radix ampelopsis, 20-40 parts of Sambucus thunbergiana;This forms synergistic function using the special compatibility relationship between bulk pharmaceutical chemicals, to have the advantages that anthemorrhagic speed is fast, analgesic effect is good;Meanwhile by the Chinese medicine composition and composite material prepared by auxiliary material or compound carrier material, it may have faster anthemorrhagic speed, and be provided with analgesic effect, make the composite material be suitable for it is a variety of in the case of hemostasis, analgesia.
Description
Technical field
The present invention relates to field of medicaments, and in particular to a kind of hemostatic traditional Chinese medicine composition and multifunctional emergency stop blooding composite wood
Material.
Background technology
Under the emergency situations such as war, major traffic accidents and natural calamity, cause to lose blood because that can not stop blooding rapidly
It is excessively the main factor for leading to died of wounds.According to statistics, in the emergency care of trauma in battlefield and usually, have in the dead wounded
40% or more is caused by excessive blood loss.Therefore hemostasis is the committed step stood in the breach in emergency care of trauma.Tradition
Hemostasis use tourniquet bandage compressing, filler oppress, but its to arterial hamorrhage, to the narrow cavity of human body such as duct, nose
Not only effect is poor for the hemostasis of chamber bleeding, but also sequelae is more.
Currently, having developed various new hemostatic material both at home and abroad, the more universal hemostatic material of application has oxidized fibre
Element and oxidized regenerated cellulose, gelfoam, microcrystalline collagen and increase coagulate gelfoam, medical polyurethane sponge, chitosan and its
Derivant material and Fibrin Glue etc..
Oxycellulose and oxidized regenerated cellulose are a kind of cotton fiber parts of absorbability of acquisition after processing
Hemostatic material has the appearance and quality of cotton yarn, is applied in present neurosurgery more.The two hemostatic mechanism is with acid
Carboxyl and iron in hemoglobin(fe3+)After ions binding, forms the damaged capillary of stickiness blob of viscose closing and stop blooding, simultaneously
Have to blood platelet and stick and aggtegation, to activate internal clotting mechanism, accelerate blood coagulation, meets in vivo slowly molten after blood
Solution is absorbed in general 3~6 weeks.
Collagen hemostatic includes that gelfoam etc. is coagulated in gelfoam, microcrystalline collagen and increasing.Its porous structure absorbs blood
It is expanded after liquid, forms the rack of blood coagulation, sealing blood vessels breach or the surface of a wound, and activate blood platelet, reach hemostasis purpose.Gelfoam
It can be absorbed within about 4~6 weeks.Gelfoam hemostasis needs coagulation factor to participate in, therefore to there is the patient outcome of blood coagulation disorders not good enough.
Chitosan is the primary derivative of chitin deacetylation, is rare alkaline polysaccharide in nature.Its hemostat
Make it is complex, researches show that:Red blood cell, leucocyte and blood negatively charged in positively charged molecule and blood in chitosan
The visible components such as platelet are combined to form cell thrombus or blood coagulation bolt generation hemoglutination, while can promote the osamines such as hyaluronic acid
Polysaccharide is secreted, and is cicatrized a wound and is speeded, moreover it is possible to increase material mechanical performance etc..In the animal of intravenous injection heparin, chitosan
Equally there is haemostatic effect, illustrate the hemoglutination of chitosan independent of coagulation factor and blood platelet, thus can be used for blood coagulation
Dysfunction.In addition, chitosan also has the effect for inhibiting various bacteria and fungi growth, the surface of a wound made by chitosan to apply
Material has water suction oxygen permeability, flexibility and degradability so that the wound tissue under dressing can obtain enough partials pressure of oxygen, favorably
In the growth and reparation of epithelial cell, while inhibiting the function of fibroblastic growth.
Fibrin Glue is extracted from people or mammalian plasma, by fibrinogen, fibrin ferment, Aprotinin and chlorination
A kind of biological hemostatic binder of calcium composition.Its hemostatic mechanism is the fibrinogen and coagulation factor analog machine by high concentration
3rd stage of body blood coagulation, and directly form one layer of fibrin film in the surface of a wound and effectively stop blooding.It is with good hemostasis, glutinous
Performance and histocompatbility are closed, intraoperative blood loss can be largely reduced, it is especially suitable to being associated with coagulation disorders patient, this
Outside, Fibrin Glue can also play the role of binder, and the tissue of separation is made to be easier to be combined together, the small surface of a wound can be with
Save stitching step.
Although above-mentioned hemostatic material all achieves good haemostatic effect in zoopery and clinical application, due to
Blood mechanism existing for hemostatic material itself is more single, anthemorrhagic speed is relatively slow and defect without analgesic effect, and is not suitable for
Hemostasis in the case of a variety of.
Invention content
Anthemorrhagic speed existing for existing hemostatic material is slow, the defect without analgesic effect it is an object of the invention to overcoming, and carries
For a kind of hemostatic traditional Chinese medicine composition and the multifunctional emergency containing the Chinese medicine composition stop blooding composite material;Chinese medicine group of the present invention
Object is closed using the special compatibility relationship between bulk pharmaceutical chemicals, forms synergistic function, to, analgesia effect fast with anthemorrhagic speed
The good advantage of fruit;Meanwhile by the Chinese medicine composition and composite material prepared by auxiliary material or compound carrier material, it may have faster
Anthemorrhagic speed, and be provided with analgesic effect, make the composite material be suitable for it is a variety of in the case of hemostasis, analgesia.
In order to achieve the above-mentioned object of the invention, the present invention provides a kind of hemostatic traditional Chinese medicine composition, including following parts by weight are former
Material medicine is prepared:It is 20-40 parts of bletilla, 20-40 parts of hairyvein agrimony, 5-15 parts of cattail pollen, 20-40 parts of Radix Notoginseng, 10-30 parts of Paris polyphylla, white
10-30 parts of liana, 20-40 parts of Sambucus thunbergiana.
Wherein, bletilla bitter, sweet, puckery;Cold nature;Return lung, liver, stomach;With astringing to arrest bleeding, the effect of detumescence and promoting granulation;
It spits blood, spits blood for treating, traumatic hemorrhage, sore swollen toxin, chapped skin.
Hairyvein agrimony bitter;It is mild-natured;Return liver, lung, the spleen channel;With astringing to arrest bleeding, the effect of stop dysentery, desinsection;It is each for treating
The card of kind bleeding, such as:Haematemesis, hematuria, have blood in stool, uterine bleeding, spitting of blood, bleeding from five sense organs or subcutaneous tissue, dysentery, internal lesion caused by overexertion power off, carbuncle swells, bruise, wound
Hinder bleeding etc..
Cattail pollen is sweet in flavor;It is mild-natured;Return liver, pericardium channel;With hemostasis, stagnation resolvation, treating stranguria effect;It spits blood for treating, bleeding from five sense organs or subcutaneous tissue,
Spitting of blood, uterine bleeding, traumatic hemorrhage, closed dysmenorrhea, gastral cavity abdomen shouting pain, tumbling and swelling, blood strangury and dry pain.
Radix Notoginseng is sweet in flavor, slight bitter;It is warm-natured;Return liver, stomach;With dissipate stasis of blood hemostasis, the effect of detumescence ding-tong;It is coughed up for treating
Blood is spitted blood, and bleeding from five sense organs or subcutaneous tissue is had blood in stool, uterine bleeding, traumatic hemorrhage, chest and abdomen shouting pain, tumbling and swelling.
Paris polyphylla bitter;Cold nature;With the effect of clearing heat and detoxicating, swelling and pain relieving, cool liver is calmed the frightened;For treating furunculosis carbuncle
It is swollen, abscess of throat, snakebite and bugbite, the pain of injury caused by falling and tumbling, convulsion.
Radix ampelopsis bitter;Cold nature;The thoughts of returning home, stomach;With clearing heat and detoxicating, the effect of carbuncle that disappears dissipating bind;For treating ulcer hair
The back of the body, furunculosis, scrofula, scald.
Sambucus thunbergiana is sweet in flavor, bitter;It is mild-natured;Return liver warp;Have effects that expelling wind and removing dampness, promoting blood circulation, hemostasis;For treating rheumatism numbness
Bitterly, gout, Kaschin-Beck disease, acute and chronic nephritis, rubella, traumatic injury, fracture swelling and pain, traumatic hemorrhage.
Hemostatic traditional Chinese medicine composition of the present invention with bletilla, cattail pollen, hairyvein agrimony altogether for monarch drug in a prescription, the work(of row astringing to arrest bleeding;With Radix Notoginseng,
Paris polyphylla is ministerial drug, the work(of row invigorating blood circulation analgesia altogether;With radix ampelopsis, Sambucus thunbergiana altogether for adjutant, work(that row detumescence and promoting granulation, synthetism are cured the wound;It is all
Medicine shares, synergistic, has significantly and quick hemostatic analgesia effect, and have no toxic side effect, also has rush to the healing of wound
Into effect.
Wherein, it is preferred that the hemostatic traditional Chinese medicine composition includes that following raw material medicine is prepared:Bletilla 25-35
Part, 25-35 parts of hairyvein agrimony, 8-12 parts of cattail pollen, 25-35 parts of Radix Notoginseng, 15-25 parts of Paris polyphylla, 15-25 parts of radix ampelopsis, Sambucus thunbergiana 25-35
Part;Most preferably, the hemostatic traditional Chinese medicine composition includes that following raw material medicine is prepared:30 parts of bletilla, hairyvein agrimony 30
Part, 10 parts of cattail pollen, 30 parts of Radix Notoginseng, 20 parts of Paris polyphylla, 20 parts of radix ampelopsis, 30 parts of Sambucus thunbergiana.By preferred, obtained Chinese medicine composition
Hemostatic analgesia speed is faster, more preferable to the healing facilitation effect of wound.
Wherein, it is preferred that can also be added in the Chinese medicine composition with astringing to arrest bleeding, invigorating blood circulation analgesia, detumescence and promoting granulation,
The Chinese medicine that synthetism is cured the wound carries out compatible use, can increase the drug effect of Chinese medicine composition;Wherein, the Chinese medicine includes radix ampelopsis, flower
Stamen stone, folium artemisiae argyi, garden burnet, sophora flower, setose thistle, field thistle, rhizoma imperatae, dragon's blood, catechu, pollen pini, Girald Pteroxygonum Root, water river sword, flies at cacumen biotae
Dragon the palm blood, Chinese small iris, Daylily Root, insect wax, Radix Melastomae, take root, painted euphorbia herb, Callicarpa bodinieri Levl., crinis trachycarpi, carbonized hair, madder, drop
It is one or more in perfume, rhizoma typhonii, rhizoma nelumbinis, dragon's blood, clinopodium polycephalum, teasel root, acalyphae,herba.
Wherein, hemostatic traditional Chinese medicine composition of the present invention is by carrying bulk pharmaceutical chemicals through what Chinese medicine customary preparation methods were prepared
Take object;The customary preparation methods include the existing Chinese medicines extracting method such as alcohol extracting, reflux, supercritical extract.
In order to achieve the above-mentioned object of the invention, further, the present invention provides a kind of multifunctional emergency stop blooding composite material,
The composite material is to fill hemostatic for external use agent, dressing or wound made of above-mentioned Chinese medicine composition and customary adjuvant or carrier
Agent;Such as ointment, emplastrum, powder, gelling agent, medicine fourth, patch, paste, tape shape agent, liniment, solution, porous material
Deng.Composite material of the present invention contains hemostatic traditional Chinese medicine composition, and hemostatic analgesia is more rapid, more preferable to wound healing facilitation effect.
Wherein, it is preferred that the composite material contains following parts by weight raw material:Degradable medical high molecular material 40-
60 parts, 20-30 parts of Chinese medicine composition, 1-5 parts of disinfection preservative.By preferred, make composite material that not only there is excellent hemostasis
Effect, meanwhile, disinfection, sterilization, anti-corrosion, analgesia function are also had both, wound infection probability is reduced, extends the guarantor of composite material
The matter phase.
Wherein, it is preferred that the degradable medical high molecular material includes chitosan and its derivative, oxidized fibre
Element, gelfoam, microcrystalline collagen, increases and coagulates gelfoam, polyethanol acidic group sponge, aliphatic polyester, gathers oxidized regenerated cellulose
The one or more of amino acid, polyvinyl alcohol, polylactic acid, polycaprolactone, polyphosphazene, medical polyurethane etc.;By preferred, make
Composite material have it is safe and non-toxic, can dissolve and gelling characteristic, be applicable to it is a variety of in the case of hemostasis.
It is further preferred that the degradable medical high molecular material be chitosan and its derivative in one kind or
It is a variety of;Chitosan and its derivative have it is clearing heat and detoxicating, relieve oedema or abdominal distension through diuresis or purgation subtract Huang, inducing diuresis to remove edema, moisturizing are promoted the production of body fluid, disperse accumulation stagnation resolvation, softening hard masses knot
It dissipates, hemostasia and promoting granulation, promoting blood circulation and removing blood stasis, nourishing yin-nourishing, shade removing, eliminating pathogens, mend the effect of essence consolidates;Meanwhile in chitosan
Positively charged molecule is combined to form cell with visible components such as red blood cell negatively charged in blood, leucocyte and blood platelets
Embolus or blood coagulation bolt generate hemoglutination, and the glycosaminoglycans such as hyaluronic acid can be promoted to secrete, cicatrize a wound and speed, moreover it is possible to increase
Material mechanical performance etc.;It is found through experiment, chitosan and its derivative is shared with above-mentioned hemostatic traditional Chinese medicine composition, can generate collaboration
Synergistic effect makes the anthemorrhagic speed of composite material further increase.
Most preferably, the degradable medical high molecular material is deacetylation chitosan;Deacetylation chitosan
Trauma hemostasis, improve speed of wound healing, prevention wound face infection, accelerate bone reparation, promote vascular smooth muscle regeneration,
It is curative for effect to repair damaged peripheral nerves, treatment burn and scald etc., the comprehensive performance of composite material can be further increased, especially
It is more preferable to the effect for promoting wound healing.
Wherein, it is preferred that the disinfection preservative is one or more in quarternary ammonium salt compound or polymeric biguanide;Into
One step is preferred, and the disinfection preservative is compound double-chain quaternary ammonium salt such as benzalkonium bromide, chlorhexidine, poly- aminopropyl
It is one or more in biguanides, poly hexamethylene biguanide;Most preferably, the disinfection preservative is polyaminopropyl biguanide.It is logical
It crosses preferably, the anti-corrosion effect of composite material can be made more preferable, the shelf-life is longer, and does not generate toxic side effect.
Wherein, multifunctional emergency hemostasis composite material of the present invention is prepared by the existing customary preparation methods in this field
It arrives.
Compared with prior art, beneficial effects of the present invention:
1, there is synergistic function, Chinese medicine composition to have notable and quick between hemostatic traditional Chinese medicine composition bulk pharmaceutical chemicals of the present invention
Hemostatic analgesia effect, and have no toxic side effect, wound healing can be promoted.
2, multifunctional emergency hemostasis composite material of the present invention contains hemostatic traditional Chinese medicine composition, and hemostatic analgesia is rapider, right
The facilitation effect of wound healing is more preferable.
3, chitosan and its derivative and hemostatic traditional Chinese medicine composition share in multifunctional emergency hemostasis composite material of the present invention,
Synergistic function can be generated, the anthemorrhagic speed of composite material is made and the healing facilitation effect of wound is further increased.
Specific implementation mode
With reference to test example and specific implementation mode, the present invention is described in further detail.But this should not be understood
It is only limitted to embodiment below for the range of the above-mentioned theme of the present invention, it is all that this is belonged to based on the technology that the content of present invention is realized
The range of invention.
Embodiment 1
A kind of multifunctional emergency styptic sponge is prepared by following parts by weight raw material:50 parts of deacetylation chitosan, in
25 parts of drug composition, 2 parts of polyaminopropyl biguanide;
Wherein, the Chinese medicine composition is prepared by following raw material medicine:30 parts of bletilla, 30 parts of hairyvein agrimony, cattail pollen
10 parts, 30 parts of Radix Notoginseng, 20 parts of Paris polyphylla, 20 parts of radix ampelopsis, 30 parts of Sambucus thunbergiana;
Specific preparation method is as follows:(1)By 30 parts of bletilla, 30 parts of hairyvein agrimony, 10 parts of cattail pollen, 30 parts of Radix Notoginseng, 20 parts of Paris polyphylla, white
20 parts of liana, 30 parts of Sambucus thunbergiana are uniformly mixed after crushing respectively, obtain mixed raw material medicine;The mixed raw material medicine for taking 25 parts, with 95% second
Alcohol carries out alcohol extracting, concentrated, be dried to obtain Chinese medicine composition, spare;
(2)By step(1)The Chinese medicine composition of middle preparation mixed with 2 parts of polyaminopropyl biguanide after with 50 parts of deacetylated base enclosure
Glycan is loaded, and multifunctional emergency styptic sponge is obtained.
Embodiment 2
A kind of multifunctional emergency styptic sponge is prepared by following parts by weight raw material:40 parts of polyethanol acidic group sponge, Chinese medicine
30 parts of composition, 1 part of chlorhexidine;
Wherein, the Chinese medicine composition is prepared by following raw material medicine:20 parts of bletilla, 40 parts of hairyvein agrimony, cattail pollen 5
Part, 40 parts of Radix Notoginseng, 10 parts of Paris polyphylla, 30 parts of radix ampelopsis, 20 parts of Sambucus thunbergiana;
Specific preparation method is as follows:(1)20 parts of bletilla, 40 parts of hairyvein agrimony, 5 parts of cattail pollen, 40 parts of Radix Notoginseng, 10 parts of Paris polyphylla, radix ampelopsis
30 parts, 20 parts of Sambucus thunbergiana crush respectively after be uniformly mixed, obtain mixed raw material medicine;The mixed raw material medicine for taking 30 parts, with 95% ethyl alcohol
Alcohol extracting is carried out, it is concentrated, be dried to obtain Chinese medicine composition, it is spare;
(2)By step(1)The Chinese medicine composition of middle preparation mixed with 1 part of chlorhexidine after with 40 parts of polyglycolic acid
Base sponge is loaded, and multifunctional emergency styptic sponge is obtained.
Embodiment 3
A kind of multifunctional emergency hemostasis paste, is prepared by following parts by weight raw material:40 parts of polylactic acid, Chinese medicine composition 20
Part, compound double-chain quaternary ammonium salt such as 5 parts of benzalkonium bromide;
Wherein, the Chinese medicine composition is prepared by following raw material medicine:40 parts of bletilla, 20 parts of hairyvein agrimony, cattail pollen
15 parts, 20 parts of Radix Notoginseng, 30 parts of Paris polyphylla, 10 parts of radix ampelopsis, 40 parts of Sambucus thunbergiana;
Specific preparation method is as follows:(1)By 40 parts of bletilla, 20 parts of hairyvein agrimony, 15 parts of cattail pollen, 20 parts of Radix Notoginseng, 30 parts of Paris polyphylla, white
10 parts of liana, 40 parts of Sambucus thunbergiana are uniformly mixed after crushing respectively, obtain mixed raw material medicine;The mixed raw material medicine for taking 20 parts, with 95% second
Alcohol carries out refluxing extraction, concentrated, be dried to obtain Chinese medicine composition, spare;
(2)By step(1)The Chinese medicine composition of middle preparation mixed with 5 parts of compound double-chain quaternary ammonium salt such as benzalkonium bromide after with 40 parts
Poly-lactic acid material loaded, obtain multifunctional emergency hemostasis paste.
Embodiment 4
A kind of multifunctional emergency hemostasis ointment, is prepared by following parts by weight raw material:60 parts of oxycellulose, Chinese traditional medicine composition
20 parts of object, 1 part of poly hexamethylene biguanide;
Wherein, the Chinese medicine composition is prepared by following raw material medicine:25 parts of bletilla, 35 parts of hairyvein agrimony, cattail pollen 8
Part, 25 parts of Radix Notoginseng, 25 parts of Paris polyphylla, 15 parts of radix ampelopsis, 35 parts of Sambucus thunbergiana;
Specific preparation method is as follows:(1)By 25 parts of bletilla, 35 parts of hairyvein agrimony, 8 parts of cattail pollen, 25 parts of Radix Notoginseng, 25 parts of Paris polyphylla, white
15 parts of liana, 35 parts of Sambucus thunbergiana are uniformly mixed after crushing respectively, obtain mixed raw material medicine;The mixed raw material medicine for taking 20 parts, with 95% second
Alcohol carries out refluxing extraction, concentrated, be dried to obtain Chinese medicine composition, spare;
(2)By step(1)The Chinese medicine composition of middle preparation mixed with 1 part of poly hexamethylene biguanide after with 60 parts of oxidized fibre
Element is loaded, and multifunctional emergency hemostasis ointment is obtained.
Embodiment 5
A kind of multifunctional emergency hemostasis filler, is prepared by following parts by weight raw material:60 parts of polyaminoacid, Chinese medicine group
Close 30 parts of object, 5 parts of polyaminopropyl biguanide;
Wherein, the Chinese medicine composition is prepared by following raw material medicine:35 parts of bletilla, 25 parts of hairyvein agrimony, cattail pollen
12 parts, 35 parts of Radix Notoginseng, 15 parts of Paris polyphylla, 25 parts of radix ampelopsis, 25 parts of Sambucus thunbergiana;
Specific preparation method is as follows:(1)By 35 parts of bletilla, 25 parts of hairyvein agrimony, 12 parts of cattail pollen, 35 parts of Radix Notoginseng, 15 parts of Paris polyphylla, white
25 parts of liana, 25 parts of Sambucus thunbergiana are uniformly mixed after crushing respectively, obtain mixed raw material medicine;The mixed raw material medicine for taking 30 parts, using super
Critical method for extraction obtains Chinese medicine composition, spare;
(2)By step(1)The Chinese medicine composition of middle preparation mixed with 5 parts of polyaminopropyl biguanide after with 60 parts of polyaminoacid into
Row load obtains multifunctional emergency hemostasis filler.
Comparative example 1
A kind of multifunctional emergency hemostasis medicinal powder, is prepared by following raw material medicine:30 parts of bletilla, 30 parts of hairyvein agrimony, Pu
10 parts yellow, 30 parts of Radix Notoginseng, 20 parts of Paris polyphylla, 20 parts of radix ampelopsis, 30 parts of Sambucus thunbergiana;
Specific preparation method is as follows:By 30 parts of bletilla, 30 parts of hairyvein agrimony, 10 parts of cattail pollen, 30 parts of Radix Notoginseng, 20 parts of Paris polyphylla, radix ampelopsis
20 parts, 30 parts of Sambucus thunbergiana crush respectively after be uniformly mixed, obtain mixed raw material medicine;Again by mixed raw material medicine, carried out with 95% ethyl alcohol
Alcohol extracting, concentrated, be dried to obtain Chinese medicine composition, i.e. multifunctional emergency stops blooding medicinal powder.
Comparative example 2
A kind of multifunctional emergency styptic sponge is prepared by following parts by weight raw material:50 parts of deacetylation chitosan gathers
2 parts of aminopropyl biguanides;
Specific preparation method is as follows:2 parts of polyaminopropyl biguanide is loaded with 50 parts of deacetylation chitosan, is obtained
Multifunctional emergency styptic sponge.
Comparative example 3
A kind of multifunctional emergency styptic sponge is prepared by following parts by weight raw material:50 parts of gelfoam, Chinese traditional medicine composition
25 parts of object, 2 parts of polyaminopropyl biguanide;
Wherein, the Chinese medicine composition is prepared by following raw material medicine:30 parts of bletilla, 30 parts of hairyvein agrimony, cattail pollen
10 parts, 30 parts of Radix Notoginseng, 20 parts of Paris polyphylla, 20 parts of radix ampelopsis, 30 parts of Sambucus thunbergiana;
Specific preparation method is as follows:(1)By 30 parts of bletilla, 30 parts of hairyvein agrimony, 10 parts of cattail pollen, 30 parts of Radix Notoginseng, 20 parts of Paris polyphylla, white
20 parts of liana, 30 parts of Sambucus thunbergiana are uniformly mixed after crushing respectively, obtain mixed raw material medicine;The mixed raw material medicine for taking 25 parts, with 95% second
Alcohol carries out alcohol extracting, concentrated, be dried to obtain Chinese medicine composition, spare;
(2)By step(1)The Chinese medicine composition of middle preparation mixed with 2 parts of polyaminopropyl biguanide after with 50 parts of gelfoam into
Row load, obtains multifunctional emergency styptic sponge.
Comparative example 4
A kind of multifunctional emergency styptic sponge is prepared by following parts by weight raw material:50 parts of deacetylation chitosan, in
25 parts of drug composition, 2 parts of polyaminopropyl biguanide;
Wherein, the Chinese medicine composition is prepared by following raw material medicine:30 parts of clinopodium polycephalum, 30 parts of hairyvein agrimony, Pu
10 parts yellow, 30 parts of Radix Notoginseng, 20 parts of Paris polyphylla, 20 parts of radix ampelopsis, 30 parts of Sambucus thunbergiana;
Specific preparation method such as embodiment 1.
Comparative example 5
A kind of multifunctional emergency styptic sponge is prepared by following parts by weight raw material:50 parts of deacetylation chitosan, in
25 parts of drug composition, 2 parts of polyaminopropyl biguanide;
Wherein, the Chinese medicine composition is prepared by following raw material medicine:30 parts of bletilla, 30 parts of hairyvein agrimony, cattail pollen
10 parts, 30 parts of teasel, 20 parts of Paris polyphylla, 20 parts of radix ampelopsis, 30 parts of Sambucus thunbergiana;
Specific preparation method such as embodiment 1.
Comparative example 6
A kind of multifunctional emergency styptic sponge is prepared by following parts by weight raw material:50 parts of deacetylation chitosan, in
25 parts of drug composition, 2 parts of polyaminopropyl biguanide;
Wherein, the Chinese medicine composition is prepared by following raw material medicine:30 parts of bletilla, 30 parts of hairyvein agrimony, cattail pollen
20 parts, 30 parts of Radix Notoginseng, 20 parts of Paris polyphylla, 20 parts of radix ampelopsis, 30 parts of Sambucus thunbergiana;
Specific preparation method such as embodiment 1.
Comparative example 7
A kind of multifunctional emergency styptic sponge is prepared by following parts by weight raw material:50 parts of deacetylation chitosan, in
25 parts of drug composition, 2 parts of polyaminopropyl biguanide;
Wherein, the Chinese medicine composition is prepared by following raw material medicine:30 parts of bletilla, 10 parts of cattail pollen, Radix Notoginseng 30
Part, 20 parts of Paris polyphylla, 20 parts of radix ampelopsis, 30 parts of Sambucus thunbergiana;
Specific preparation method such as embodiment 1.
Comparative example 8
A kind of multifunctional emergency styptic sponge is prepared by following parts by weight raw material:50 parts of deacetylation chitosan, in
25 parts of medicine, 2 parts of polyaminopropyl biguanide;
Wherein, the Chinese medicine is prepared by hairyvein agrimony;
Specific preparation method such as embodiment 1.
Effect experiment:
1, experimental subjects:Cleaning grade healthy rabbits 42, weight 2.5-3.0 kg all select male rabbit.
2, experimental method:Using modeling and interference method
Specific experiment step:Experimental rabbit is deprived of food but not water 6 h, is anaesthetized with chloraldurate auricular vein, by postanesthetic 42
Male rabbit is randomly divided into 14 groups, every group 3, and numbers(5 groups of experimental group, 8 groups of control group, the hero in 1 group, every group of blank control group
It is No. 1, No. 2, No. 3 that rabbit is numbered respectively);Rabbit is lain on the back on experimental bench, fixing head and four limbs, belly shaving;Part disappears
Incision skin to the right is hit exactly in abdomen under germ-free condition after poison, successively opens abdomen:Each experimental group of exposure, each control group subcutaneous abdomen are soft
Tissue, with knife blade, the cutting on 42 rabbit abdomens forms one and is about 3 cm respectively, away from the deep about 0.3cm respectively of skin,
The surface of a wound of 0.6cm, 0.9cm(Every group No. 1 is 0.3cm, and No. 2 are 0.6cm, and No. 3 are 0.9cm), until surface of a wound blood exosmoses rapidly, with
After sterile gauze blots cutting part blood, each group is completed at the same time rapidly following operation:
The composite material being prepared in embodiment 1-5 and comparative example 1-8 is respectively used to corresponding one to five group of experimental group and right
According to the rabbit wound surface of one to eight group of group, every dosage 1.0-2.0 g records bleeding stopping period;Blank control group 1, No. 2,3
The bleeding surface of a wound of number rabbit blots the time rear without any processing, record bleeding to bleeding stops naturally with sterile gauze.
Post surgery treatment:The surface of a wound is wrapped up or sutured after the completion of experiment, and rabbit is put back in cage and is raised 4 weeks.Postoperative continuous 3 d fleshes
It notes gentamicin 40,000 U/ times, 3 times a day, observes animal activity situation daily.
Haemostatic effect is observed:Respectively after continuous one or two administrations of the surface of a wound, haemostatic effect is observed, blood flow stops indicating hemostasis
Success, and record and stop the bleeding time.
1. haemostatic effect:Hemostasis, bleeding stop completely completely;Not exclusively hemostasis, bleeding mitigate before relatively applying composite material
But do not stop completely;Hemostasis failure, it is unchanged using bleeding before and after composite material.
2. bleeding stopping period:Observe that the time interval that bleeding stops completely is bleeding stopping period from using composite material.Ginseng
The all personnel of experimental study is added to pass through system training, bleeding stopping period assessment uses double, double-blind study timing.
3. whether there is or not bleedings again:From complete hemostasis bleeding part bleeding once again under without outer force effect.
4. hemostasis is invalid:Observing time up to 5 min then record bleeding stopping period as stopped blooding in 5 min;More than 5
Min does not stop blooding yet, then hemostasis is invalid, should control bleeding using other surgical hemostasis modes, and record Chu Xueshijian >5 min.
5. whether there is or not death for 4 weeks rabbit after experiment.
Observe wound healing situation:A wound healing situation is observed every 12h, and records observation result.
Experimental record result:
Note:"+" is more, illustrates that wound healing situation is better
To known to above-mentioned analysis of experimental results:The composite material being prepared using the method for the present invention(Experimental group)With excellent
Haemostatic effect can realize quick-acting haemostatic powder to wound;And deacetylation chitosan is not added in control group one as carrier and auxiliary
Hemostasis, directly uses hemostatic traditional Chinese medicine composition as hemostatic material, although can also realize the effect stopped blooding completely, bleeding stopping period
Significantly extend, and the healing state of wound is remarkably decreased, meanwhile, in hemostasis, Chinese medicine composition is easy to be washed away by blood, right
Hemostasis has some impact on;In control group two, hemostatic traditional Chinese medicine composition is not used, deacetylation chitosan is used only as hemostasis
Material, although equally can realize the effect stopped blooding completely, bleeding stopping period is too long, is unfavorable for practical application, and the healing of wound
Poor effect;In control group three, the carrier and auxiliary hemostatic material that use are gelfoam, and obtained composite material also has very
Good haemostatic effect and shorter bleeding stopping period, but average bleeding stopping period is less than experimental example one, meanwhile, the healing state of wound
It is worse than experimental example one, it is known that the auxiliary haemostatic effect of gelfoam is less than deacetylation chitosan;Clinopodium polycephalum is used in control group four
The monarch drug in a prescription bletilla striata of Chinese medicine composition is substituted, the synergistic function of Chinese medicine composition is caused to disappear, anthemorrhagic speed significantly reduces,
The healing facilitation effect of wound is significantly reduced;The ministerial drug Radix Notoginseng of Chinese medicine composition is substituted in control group five with teasel,
The synergistic function of Chinese medicine composition is caused to disappear, anthemorrhagic speed significantly reduces, also notable to the healing facilitation effect of wound
It reduces;The dosage of monarch drug in a prescription cattail pollen is excessive in control group six, be more than present invention provide that dosage, also result in the association of Chinese medicine composition
It disappears with synergistic effect, anthemorrhagic speed significantly reduces, and also decreases to the healing facilitation effect of wound;In in control group seven
Drug composition lacks monarch drug in a prescription hairyvein agrimony, and the synergistic function of Chinese medicine composition is caused to disappear, and anthemorrhagic speed significantly reduces, to wound
The healing facilitation effect of mouth is significantly reduced;Only use hairyvein agrimony as Hemostatic of traditional herb medicine in control group eight, although also having centainly
Promote the effect of hemostasis, but haemostatic effect is poor, it is poor to the healing facilitation effect of wound, meanwhile, the haemostatic effect with control group seven
It is added, is less than the haemostatic effect of experimental group one of the present invention, i.e., there is synergistic function, hemostasis between Chinese medicine composition of the present invention
Significant effect increases.
Claims (10)
1. a kind of hemostatic traditional Chinese medicine composition, which is characterized in that be prepared including following raw material medicine:20-40 parts of bletilla,
20-40 parts of hairyvein agrimony, 5-15 parts of cattail pollen, 20-40 parts of Radix Notoginseng, 10-30 parts of Paris polyphylla, 10-30 parts of radix ampelopsis, 20-40 parts of Sambucus thunbergiana.
2. Chinese medicine composition according to claim 1, which is characterized in that be prepared including following raw material medicine:
25-35 parts of bletilla, 25-35 parts of hairyvein agrimony, 8-12 parts of cattail pollen, 25-35 parts of Radix Notoginseng, 15-25 parts of Paris polyphylla, 15-25 parts of radix ampelopsis, synthetism
It is 25-35 parts careless.
3. Chinese medicine composition according to claim 2, which is characterized in that be prepared including following raw material medicine:
30 parts of bletilla, 30 parts of hairyvein agrimony, 10 parts of cattail pollen, 30 parts of Radix Notoginseng, 20 parts of Paris polyphylla, 20 parts of radix ampelopsis, 30 parts of Sambucus thunbergiana.
The composite material 4. a kind of multifunctional emergency stops blooding, which is characterized in that be by any one of the claim 1-3 Chinese traditional medicine compositions
Object and hemostatic for external use agent, dressing or wound filler made of customary adjuvant or carrier.
5. composite material according to claim 4, which is characterized in that the composite material contains following parts by weight former material
Material:40-60 parts of degradable medical high molecular material, 20-30 parts of Chinese medicine composition, 1-5 parts of disinfection preservative.
6. composite material according to claim 5, which is characterized in that the degradable medical high molecular material includes that shell is poly-
Carbohydrates and their derivative, oxidized regenerated cellulose, gelfoam, microcrystalline collagen, increases and coagulates gelfoam, polyethanol oxycellulose
One in acidic group sponge, aliphatic polyester, polyaminoacid, polyvinyl alcohol, polylactic acid, polycaprolactone, polyphosphazene, medical polyurethane
Kind is a variety of.
7. composite material according to claim 6, which is characterized in that the degradable medical high molecular material is chitosan
And its it is one or more in derivative.
8. composite material according to claim 7, which is characterized in that the degradable medical high molecular material is deacetylated
Base enclosure glycan.
9. composite material according to claim 5, which is characterized in that the disinfection preservative includes quarternary ammonium salt compound
Or it is one or more in polymeric biguanide.
10. composite material according to claim 9, which is characterized in that the disinfection preservative is polyaminopropyl biguanide.
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