CN106729962A - A kind of antibacterial skin protection film liquid and preparation method thereof - Google Patents

A kind of antibacterial skin protection film liquid and preparation method thereof Download PDF

Info

Publication number
CN106729962A
CN106729962A CN201611186246.8A CN201611186246A CN106729962A CN 106729962 A CN106729962 A CN 106729962A CN 201611186246 A CN201611186246 A CN 201611186246A CN 106729962 A CN106729962 A CN 106729962A
Authority
CN
China
Prior art keywords
preparation
film liquid
antibacterial skin
antibacterial
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201611186246.8A
Other languages
Chinese (zh)
Other versions
CN106729962B (en
Inventor
苏晓明
杨毅
李乘风
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qingdao Chen Blue Ocean Biological Engineering Co Ltd
Original Assignee
Qingdao Chen Blue Ocean Biological Engineering Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qingdao Chen Blue Ocean Biological Engineering Co Ltd filed Critical Qingdao Chen Blue Ocean Biological Engineering Co Ltd
Priority to CN201611186246.8A priority Critical patent/CN106729962B/en
Publication of CN106729962A publication Critical patent/CN106729962A/en
Application granted granted Critical
Publication of CN106729962B publication Critical patent/CN106729962B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention relates to a kind of antibacterial skin protection film liquid and preparation method thereof.The primary raw material composition of the antibacterial skin protection film liquid：Bactericide, absolute ethyl alcohol, film forming matrix, plasticizer, cosolvent, plants essential oil, marine algae extract, purified water.Principle active component of the present invention is bactericide, film forming matrix; as a kind of film-forming type antibacterial and protective preparation; after being applied to skin; high resilience, transparent glued membrane can be formed; the bactericidal composition of the bacterium in isolation external environment, glued membrane and its internal load can carry out sustainable protection, and ventilative, waterproof and dustproof to skin; the daily emergency antibacterial and protective for being contacted with water, can be used for cut wound, incised wound, wiping the minor cut or wounds such as scratch, chap, hangnail such as do not influence to take a shower, swim.

Description

A kind of antibacterial skin protection film liquid and preparation method thereof
Technical field
The invention belongs to the protection film liquid technical field of antibacterial skin, and in particular to a kind of antibacterial skin protection film liquid and its Preparation method.
Background technology
In daily life, people occur some collision frictions frequently, cause some small wounds, such as abrade, stab, cut Hinder, scratch, biting, squeezing wound, cut wound etc., people can often be bound up a wound when injury using adhesive bandage, so as to avoid wound Mouthfeel contaminates.Traditional adhesive bandage can hemostasis by compression, protect wound, avoid wound infection, with small volume, carry it is convenient, make The advantages of using simple, but traditional adhesive bandage is not convenient to use when wound is irregular, and the surface of a wound can not for a long time contact water, such as For a long time contact the water capacity easily cause wound infection, the adhesive plaster poor air permeability that it is used, the normocrinic steam of body local and Sweat can not penetrate this layer of adhesive plaster, easily produce immersion to local skin；And some are new as liquid adhesive bandage, liquid are applied Material, wound spray-filming agent, liquid protective film, skin degerming film liquid etc. can improve limitation when traditional adhesive bandage is used, and have Waterproof, resistance bacterium, it is ventilative, easy to use, beneficial to observation wound the advantages of, recent domestic is to this kind of new liquid shield wound product The concern of product is more and more.
New liquid shield wound class product can further meet the sterilized emergency nursing demand of the daily wound disinfection of people, mainly Including consisting of part：Contain filmogen in liquid, diaphragm can be formed in wound, play a part of waterproof, resistance bacterium； Add coordinative solvent, cosolvent and dissolve filmogen, beneficial to fast filming；Other functions material, mainly plasticizer, help Stick, bacteriostatic agent promote the functional mass for healing；Fully combine the functional materials such as filmogen and plasticizer, bacteriostatic agent Excellent properties, energy rapid draing simultaneously forms ventilative, waterproof, resilient diaphragm, effectively antibacterial, promotion wound healing, reduction Scar is formed.
Authorization Notice No. provides a kind of skin superficies insulation protecting film and its system for the patent of invention of CN100553609C Preparation Method, the main technical schemes of the patent are：Raw material including following mass percent, bactericide 0.5%, dimethyl silica Alkane polyether high molecular polymer 3% ~ 6%, natrosol high molecular polymer 1% ~ 4%, polyaminoamide 2% ~ 5%th, propane diols 1% ~ 3%, glycerine 4% ~ 7%, ethanol 4% ~ 6%, tea oil 0.1% ~ 0.4%, balance of water.The skin Superficies insulation protecting film has loaded effective sterilization component and skin supplement ingredient, and the film layer formed in skin surface has good Isolating and protecting effect, the various poisonous and hazardous chemical substance that skin surface is likely to be exposed can be effectively isolated, such as acid, alkali, Heavy metal, organic matter and microorganism etc., can reach the long-acting bactericidal of 4 ~ 6 h and nourish, and a small amount of clear water of the protecting film is with regard to energy Remove easily, so its water resistance could be improved.
A kind of Authorization Notice No. surface of a wound protection liquid with water proofing property for the patent of invention of CN102058900B is provided Body bandage and preparation method thereof, the liquid bandage mainly includes absolute ethyl alcohol, ethyl acetate, nitrocellulose, acetyl tributyl citrate Tributyl, isopropyl palmitate and vitamin e acetate, its advantage are with water proofing property, physical protection, promote wound healing etc. Function, safety and environmental protection, film forming speed are fast and easy to use, comfortableness is good, the skin superficial wound such as are mainly used in abrading, hurt The protection in face, but the liquid bandage is applied to during the use of the surface of a wound and has penetrating odor, the comfort that influence is used.
The content of the invention
In order to overcome the deficiencies in the prior art, there is provided a kind of antibacterial skin protection film liquid and preparation method thereof, the present invention is adopted Use following technical scheme：
A kind of antibacterial skin protection film liquid and preparation method thereof, it is characterised in that by the raw material preparation of following mass percent Into：Bactericide 0.1% ~ 1.5%, absolute ethyl alcohol 45.5% ~ 70.0%, film forming matrix 6.3% ~ 20.0%, plasticizer 0.5 ~ 3.5%, cosolvent 0.5 ~ 2.0%, plants essential oil 0.1 ~ 1.2%, marine algae extract 0.2 ~ 1.3%, balance of water.
Described bactericide be Triclosan, PCMX, TCC in one kind or Various mixtures.
Described film forming matrix is polyacrylic resin.
Described plasticizer be ATBC, diethyl phthalate, PEG-4000, polyethylene glycol- 4000th, one kind in PEG-4000.
Described cosolvent is the one kind in propane diols, glycerine.
Described plants essential oil is the one kind in tea oil, eucalyptus oil.
Described marine algae extract is preferably compatibile extract.
One kind prepares antibacterial skin protection film liquid as described above, and specific preparation process is as follows：
1）The absolute ethyl alcohol and purified water for taking formula ratio are well mixed, and obtain ethanol solution；
2）To polyacrylic resin is added in above-mentioned mixed liquor, stirring is completely dissolved to it, obtains transparent homogeneous mixed solution；
3）Bactericide, plasticizer, cosolvent, plants essential oil, the sea of formula ratio are sequentially added in transparent homogeneous mixed solution Algae extract, is evenly stirred until and is completely dissolved；
4）Finally by the filtering of above-mentioned gained mixed solution, simultaneously vacuum sloughs bubble, obtains homogeneous antibacterial skin protection film liquid.
The beneficial effects of the invention are as follows:
1）This antibacterial skin protection film liquid is film-forming type shield wound antiseptic, and preparation process is simple does not receive skin surface shape when using Shape, size, the limitation at position, can be applied to that joint, fold etc. be irregular, not easy-operating position, easily apply exhibition, smear after not The activity at the positions such as influence joint, solves the limitation that tradition shield wound antimicrobial product is not readily used for irregular position, is applied to skin Skin has antibacterial, the effect of anti-inflammatory, there is preferable protective effect to skin surface;
2）This antibacterial skin protection film liquid can quickly form high resilience, transparent protection glued membrane after being applied to skin, protect skin Bacterium in skin and isolation external environment, the bactericide of load, plants essential oil, marine algae extract Common Persistence are acted in its film Skin, long-effective protection is carried out to skin, with lasting long-acting sterilization function, multiple-protection biocidal efficacies, and breathe freely, waterproof, It is dust-proof, do not influence to take a shower, swim etc. it is daily contacted with water, can be used for cut wound, incised wound, wipe the minor cut or wounds such as scratch, chap, hangnail Emergency antibacterial and protective.
Specific embodiment
Below by specific embodiment, technical scheme is described in further detail.
Embodiment 1
A kind of antibacterial skin protects film liquid, the raw material comprising following percentage by weight：PCMX 0.5%, anhydrous second Alcohol 58.6%, polyacrylic resin 12.5%, ATBC 2.5%, glycerine 1.5%, tea oil 0.2%, compatibile is extracted Thing 0.2%, balance of water.
Antibacterial skin protection film liquid is prepared by the raw material of above-mentioned percentage by weight, is comprised the following steps that：
1）Take 58.6g absolute ethyl alcohols and 24g purified waters are well mixed, obtain ethanol solution；
2）To 12.5g polyacrylic resins are added in above-mentioned mixed liquor, stirring is completely dissolved to it, obtains transparent homogeneous mixing Solution；
3）Sequentially added in transparent homogeneous mixed solution 0.5g PCMXs, 2.5g ATBCs, 1.5g glycerine, 0.2g tea oils, 0.2g compatibile extracts, are evenly stirred until and are completely dissolved；
4）Finally by the filtering of above-mentioned gained mixed solution, simultaneously vacuum sloughs bubble, obtains homogeneous antibacterial skin protection film liquid 1#。
Embodiment 2
A kind of antibacterial skin protects film liquid, the raw material comprising following percentage by weight：Triclosan 0.5%, absolute ethyl alcohol 62.5%, polyacrylic resin 16.2%, PEG-4000 1.5%, glycerine 1.5%, tea oil 0.3%, compatibile is extracted The % of thing 0.2, balance of water.
Antibacterial skin protection film liquid is prepared by the raw material of above-mentioned percentage by weight, is comprised the following steps that：
1）Take 62.5g absolute ethyl alcohols and 17.3g purified waters are well mixed, obtain ethanol solution；
2）To 16.2g polyacrylic resins are added in above-mentioned mixed liquor, stirring is completely dissolved to it, obtains transparent homogeneous mixing Solution；
3）0.5g Triclosans, 1.5g PEG-4000s, 1.5g are sequentially added in transparent homogeneous mixed solution Glycerine, 0.3g tea oils, 0.2g compatibile extracts, are evenly stirred until and are completely dissolved；
4）Finally by the filtering of above-mentioned gained mixed solution, simultaneously vacuum sloughs bubble, obtains homogeneous antibacterial skin protection film liquid 2#。
Embodiment 3
A kind of antibacterial skin protects film liquid, the raw material comprising following percentage by weight：TCC 0.5%, absolute ethyl alcohol 65.5%, polyacrylic resin 15.5%, PEG-4000 2.5%, the % of propane diols 0.5, eucalyptus oil 0.1%, compatibile is carried Take thing 0.2%, balance of water.
Antibacterial skin protection film liquid is prepared by the raw material of above-mentioned percentage by weight, is comprised the following steps that：
1）Take 65.5g absolute ethyl alcohols and 15.2g purified waters are well mixed, obtain ethanol solution；
2）To 15.5g polyacrylic resins are added in above-mentioned mixed liquor, stirring is completely dissolved to it, obtains transparent homogeneous mixing Solution；
3）0.5g TCCs, 2.5g PEG-4000s, 0.5g third are sequentially added in transparent homogeneous mixed solution Glycol, 0.1g eucalyptus oils, 0.2g compatibile extracts, are evenly stirred until and are completely dissolved；
4）Finally by the filtering of above-mentioned gained mixed solution, simultaneously vacuum sloughs bubble, obtains homogeneous antibacterial skin protection film liquid 3#。
Embodiment 4
Antibacterial skin protects the BA of film liquid：
Sterilized carrier-pellet is laid in sterilized petri dishes, 10 μ L bacteria suspensions is taken and is added dropwise piecewise, and smoothened entirely with oese Carrier surface, puts and used after being dried in 37 DEG C of incubators.Above-mentioned bacterium piece is taken, is separately added into and is impregnated with made in embodiment 1 ~ 3 Standby 5.0mL antibacterial skins protection film liquid 1#、2#、3#In sample liquid, start timing, effect 2,5,10,20min, with aseptic tweezer by bacterium Piece is taken out in test tube of the input containing the corresponding nertralizers of 5.0mL, is fully mixed, and makees appropriate dilution, finally takes wherein 2 ~ 3 dilutions Degree, draws 0.5mL and is directly inoculated with plate respectively, and often pipe is inoculated with 2 plates, then plate is placed in 37 DEG C of constant incubators and is trained Support 48h（Bacterium）Or 72h（Saccharomycete）, make viable bacteria colony counting, a plate is separately taken, injection 5.0mL dilutions are made instead of sample liquid It is positive controls, its subsequent test procedure is identical with above-mentioned experimental group.The sterilization of sample is evaluated by calculating sterilizing rate Performance, computational methods are as follows：
In formula：--- sterilizing rate, %；
A --- control sample average colony number；
B --- tested sample average clump count.
Killing effect of the antibacterial skin of the table 1 protection film liquid to test organisms
The result of the test of table 1 shows that antibacterial skin protection film liquid of the invention is read Escherichia coli, staphylococcus aureus, white Pearl bacterium has good killing performance.
Embodiment 5
Antibacterial skin protects the stability test of film liquid：
Antibacterial skin protection film liquid 1 prepared in Example 1 ~ 3#、2#、3#, in placing 90d, Yu Fang in 37 DEG C of insulating boxs Put it is forward and backward determine effective sterilization component content respectively, the BA in 4 is in determining its sterilizing rate in conjunction with the embodiments after placement, Each sample retest 3 times, takes its average value, and specific stability test the results are shown in Table shown in 2, table 3.
The antibacterial skin of table 2 protects the effective sterilization component assay result of film liquid
Killing effect of the antibacterial skin protection film liquid to test organisms after 3 37 DEG C of insulating box storage 90d of table
From table 2, the result of the test of table 3, antibacterial skin protection film liquid of the invention has long-time stability, in 37 DEG C of constant temperature trainings Support after case places 90d, the active constituent content rate of descent of its stoste≤5%, to Escherichia coli, staphylococcus aureus, white The killing rate of candida albicans can reach >=90%, and still with bactericidal action, its storage life is at least 2 years.
The above is presently preferred embodiments of the present invention, but the present invention should not be limited to the embodiment disclosure of that. So every do not depart from the lower equivalent or modification for completing of spirit disclosed in this invention, the scope of protection of the invention is both fallen within.

Claims (8)

1. a kind of antibacterial skin protects film liquid and preparation method thereof, it is characterised in that prepared by the raw material of following mass percent Form：Bactericide 0.1% ~ 1.5%, absolute ethyl alcohol 45.5% ~ 70.0%, film forming matrix 6.3% ~ 20.0%, plasticizer 0.5 ~ 3.5%, cosolvent 0.5 ~ 2.0%, plants essential oil 0.1 ~ 1.2%, marine algae extract 0.2 ~ 1.3%, balance of water.
2. a kind of antibacterial skin according to claim 1 protects film liquid and preparation method thereof, it is characterised in that described kills Microbial inoculum is the mixture of one or more in Triclosan, PCMX, TCC.
3. a kind of antibacterial skin protection film liquid according to claim 1 and preparation method thereof, it is characterised in that it is described into Membrane matrix is polyacrylic resin.
4. a kind of antibacterial skin according to claim 1 protects film liquid and preparation method thereof, it is characterised in that described increasing Modeling agent is ATBC, diethyl phthalate, PEG-4000, PEG-4000, PEG-4000 In one kind.
5. a kind of antibacterial skin according to claim 1 protects film liquid and preparation method thereof, it is characterised in that described helps Solvent is the one kind in propane diols, glycerine.
6. a kind of antibacterial skin according to claim 1 protects film liquid and preparation method thereof, it is characterised in that described plant Thing essential oil is the one kind in tea oil, eucalyptus oil.
7. a kind of antibacterial skin according to claim 1 protects film liquid and preparation method thereof, it is characterised in that described sea Algae extract is preferably compatibile extract.
8. a kind of antibacterial skin according to any one of claim 1 ~ 7 protects film liquid and preparation method thereof, it is characterised in that Including following preparation process：
1）The absolute ethyl alcohol and purified water for taking formula ratio are well mixed, and obtain ethanol solution；
2）To polyacrylic resin is added in above-mentioned mixed liquor, stirring is completely dissolved to it, obtains transparent homogeneous mixed solution；
3）Bactericide, plasticizer, cosolvent, plants essential oil, the sea of formula ratio are sequentially added in transparent homogeneous mixed solution Algae extract, is evenly stirred until and is completely dissolved；
4）Finally by the filtering of above-mentioned gained mixed solution, simultaneously vacuum sloughs bubble, obtains homogeneous antibacterial skin protection film liquid.
CN201611186246.8A 2016-12-21 2016-12-21 Skin antibacterial protective film liquid and preparation method thereof Active CN106729962B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201611186246.8A CN106729962B (en) 2016-12-21 2016-12-21 Skin antibacterial protective film liquid and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201611186246.8A CN106729962B (en) 2016-12-21 2016-12-21 Skin antibacterial protective film liquid and preparation method thereof

Publications (2)

Publication Number Publication Date
CN106729962A true CN106729962A (en) 2017-05-31
CN106729962B CN106729962B (en) 2020-08-07

Family

ID=58896159

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201611186246.8A Active CN106729962B (en) 2016-12-21 2016-12-21 Skin antibacterial protective film liquid and preparation method thereof

Country Status (1)

Country Link
CN (1) CN106729962B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022126629A1 (en) * 2020-12-18 2022-06-23 江苏奇力康皮肤药业有限公司 Liquid adhesive bandage and preparation method therefor
CN116159044A (en) * 2023-04-19 2023-05-26 山东安得医疗用品股份有限公司 Antibacterial skin protectant and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090123111A (en) * 2008-05-27 2009-12-02 전남대학교산학협력단 Antimicrobial agents containing essential oils loaded on polymeric beads and methods for inhibiting microbial growth using the same
CN102920615A (en) * 2011-08-08 2013-02-13 陈明智 Gum composition for external use on skin
CN104878477A (en) * 2015-05-14 2015-09-02 青岛大学 Method for preparing antibacterial alginate fibers through natural antibacterial agent
CN105797202A (en) * 2016-03-23 2016-07-27 广州瑞辉生物科技股份有限公司 Liquid band-aid and preparing method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090123111A (en) * 2008-05-27 2009-12-02 전남대학교산학협력단 Antimicrobial agents containing essential oils loaded on polymeric beads and methods for inhibiting microbial growth using the same
CN102920615A (en) * 2011-08-08 2013-02-13 陈明智 Gum composition for external use on skin
CN104878477A (en) * 2015-05-14 2015-09-02 青岛大学 Method for preparing antibacterial alginate fibers through natural antibacterial agent
CN105797202A (en) * 2016-03-23 2016-07-27 广州瑞辉生物科技股份有限公司 Liquid band-aid and preparing method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022126629A1 (en) * 2020-12-18 2022-06-23 江苏奇力康皮肤药业有限公司 Liquid adhesive bandage and preparation method therefor
CN116159044A (en) * 2023-04-19 2023-05-26 山东安得医疗用品股份有限公司 Antibacterial skin protectant and preparation method thereof
CN116159044B (en) * 2023-04-19 2023-10-13 山东安得医疗用品股份有限公司 Antibacterial skin protectant and preparation method thereof

Also Published As

Publication number Publication date
CN106729962B (en) 2020-08-07

Similar Documents

Publication Publication Date Title
US9913476B2 (en) Antimicrobial articles of manufacture produced from masterbatches
CA2963114C (en) Composition and kits for inhibition of pathogenic microbial infection and methods of using the same
CN101601382B (en) Thymol mite-killing microemulsion and preparation method thereof
CN104274490B (en) Bactericidal composition including source of silver ions and menthol and application thereof
CN104257639B (en) A kind of liniment for Wound treating and preparation method thereof
CN102058900B (en) Waterproof liquid bandage for wound surface protection and preparation method thereof
CN111345295B (en) Traditional Chinese medicine oil modified active silicon antibacterial liquid and preparation method thereof, and preparation method of antibacterial coating
CN107412847A (en) A kind of Wound dressing of liquid form and preparation method thereof
CN105055642A (en) Compound guanidine disinfectant and preparation method of compound guanidine disinfectant
CN108078959A (en) A kind of antibacterial and protective film and its preparation method and application
TW201216859A (en) Disinfectant and antiseptic formulation having reduced iodine content
CN111150697A (en) Wash-free antibacterial hand sanitizer and preparation method thereof
CN112245652A (en) Bacteriostatic liquid band-aid capable of quickly forming film and preparation method thereof
CN110478293A (en) A kind of disposable disinfection hand cleanser and preparation method thereof
CN104971377A (en) Liquid wound glue and preparation method
CN105999360B (en) A kind of antibacterial liquid adhesive bandage and preparation method thereof
CN106729962A (en) A kind of antibacterial skin protection film liquid and preparation method thereof
CN106178095A (en) A kind of antibacterial liquid Wound-protection liquid film and preparation method thereof
CN103893022A (en) Application of antibacterial peptide as preservative in preparing cosmetics
CN110420257A (en) A kind of compound mammilla of milk cattle dip and preparation method thereof
KR20150107376A (en) Antibacterials composition comprising Sedum extract composition and food additives and preparation method thereof
CN103766339B (en) The composition that contains trans-cinnamic aldehyde
Joshi et al. Evaluation of herbal handwash formulation.
WO2018156881A1 (en) Ecofriendly biofilm-disrupting antimicrobial formulations, their development, and their uses
CN106511132A (en) Anticorrosion system of infant wet tissue immersion liquid and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant