CN106178095A - A kind of antibacterial liquid Wound-protection liquid film and preparation method thereof - Google Patents
A kind of antibacterial liquid Wound-protection liquid film and preparation method thereof Download PDFInfo
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- CN106178095A CN106178095A CN201610584059.9A CN201610584059A CN106178095A CN 106178095 A CN106178095 A CN 106178095A CN 201610584059 A CN201610584059 A CN 201610584059A CN 106178095 A CN106178095 A CN 106178095A
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- parts
- wound
- antibacterial
- film
- liquid
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The present invention relates to a kind of antibacterial liquid Wound-protection liquid film and preparation method thereof, its composition of raw materials includes the component of following parts by weight: oil-soluble polyvinyl alcohol contracting alkyl aldehydes 5 ~ 50 parts；Polyacrylate 1 ~ 5 part；Heptyl acetate 15 parts；Polydimethylsiloxane 15 parts；Ethanol 150 ~ 200 parts；Camphora 0.5 ~ 1.5 part；Glycerol 5 ~ 10 parts；Isopropyl palmitate 10 ~ 20 parts；Triclosan 0.05 ~ 0.2 part.After smearing, form the film of layer of transparent at wound surface, wound can be played sterilization, restrain, analgesia etc. acts on；Antibacterial and foreign body can be stoped after smearing to immerse wound, and isolation performance is good, and water proofing property is good simultaneously；After smearing, wound surface is had analgesia, convergence, antibacterial, promotes the effects such as wound healing；Applied widely, coatable with different size, shape and the wound surface at position, place, smearing formation film has certain elasticity, coating position can activity freely；Without obvious irritation, without allergy and drug resistance, safety is high；Carry, easy to use.
Description
Technical field
The invention belongs to Medical dressing field, relate to a kind of Wound-protection liquid film, be specifically related to a kind of antibacterial liquid Wound-protection liquid film
And preparation method thereof.
Background technology
The processing method of the wound of the little area in daily life mostly is advanced person and serves a round of liquor to the guests essence or iodine disinfection, then with gauze
Or adhesive bandage wrapping or protection, although wound surface can be protected, but there is also certain drawback, such as gauze or adhesive bandage
The wrapping of the wound surface of improper privileged sites, and need repeated multiple times replacing to easily cause the secondary injury of wound, simultaneously after parcel
Poor air permeability, steam and the perspiration of wound secretion can not ooze out in time, local skin can be produced action of soaking, be easily caused antibacterial
Secondary infection, and gauze or adhesive bandage wrapping cannot completely cut off completely wound with the external world contact, be easily caused dust or water
Penetrate into wound, be unfavorable for that wound recovers.This needs exist for more practical convenient succedaneum effectively.The research of liquid adhesive bandage should
Fortune and give birth to, currently also have the research to liquid bandage, such as ZL200410031161.3, CN 102258804 A, and it ground
Study carefully and also deepening continuously, but it is the most little to protect the wound significant commercialized product of antibacterial effect.Outstanding for busy quick modern society
There is deficiency and cannot be waterproof, cause wound healing time long, and cannot effectively prevent the shortcomings such as wound infection.By antibiotic substance with
It is important research direction that new liquid Wound-protection liquid film wound surface combines.
Summary of the invention
The invention aims to overcome the deficiencies in the prior art to provide a kind of antibacterial liquid Wound-protection liquid film.
For reaching above-mentioned purpose, the technical solution used in the present invention is: a kind of antibacterial liquid Wound-protection liquid film, it includes following
The component of parts by weight:
Oil-soluble polyvinyl alcohol contracting alkyl aldehydes 5 ~ 50 parts；
Polyacrylate 1 ~ 5 part；
Polydimethylsiloxane 1 ~ 5 part；
Heptyl acetate 1 ~ 5 part；
Ethanol 150 ~ 200 parts；
Camphora 0.5 ~ 1.5 part；
Glycerol 5 ~ 10 parts；
Isopropyl palmitate 10 ~ 20 parts；
Triclosan 0.05 ~ 0.2 part.
Optimally, described oil-soluble polyvinyl alcohol contracting alkyl aldehydes is polyvinyl butyral resin, polyvinyl formal and gathers
Vinyl alcohol contract in the first and second aldehyde one or more composition mixture.
Optimally, during described polyacrylate is polymethyl acrylate, polyethyl acrylate and butyl polyacrylate
Plant or the mixture of multiple composition.
A further object of the present invention is to provide the preparation method of a kind of above-mentioned antibacterial liquid Wound-protection liquid film, and it includes following
Step:
A the oil-soluble polyvinyl alcohol contracting alkyl aldehydes of formula ratio, polyacrylate are dissolved in ethanol by (), add formula after stirring
Isopropyl palmitate, heptyl acetate, polydimethylsiloxane and the glycerol of amount, stirring is mixed to prepare film liquid；
B () adds Camphora and the triclosan of formula ratio while stirring described film liquid, mix ultrasonic.
Owing to technique scheme is used, the present invention compared with prior art has the advantage that antibacterial liquid of the present invention
Wound-protection liquid film, forms the film of layer of transparent after smearing at wound surface, wound can be played sterilization, restrain, analgesia etc. acts on；Smear
After antibacterial and foreign body can be stoped to immerse wound, isolation performance is good, and water proofing property is good simultaneously；After smearing, wound surface is had analgesia,
Convergence, antibacterial, promote the effect such as wound healing；Applied widely, coatable and different size, shape and the wound at position, place
Face, smearing formation film has certain elasticity, coating position can activity freely；Without obvious irritation, without allergy and drug resistance, safety
Property high；Carry, easy to use.
Accompanying drawing explanation
Accompanying drawing 1 is the antibacterial test design sketch of antibacterial liquid Wound-protection liquid film in embodiment 1；
Accompanying drawing 2 is the cytotoxicity test figure of antibacterial liquid Wound-protection liquid film in embodiment 1；
Accompanying drawing 3 is the antibacterial test design sketch of antibacterial liquid Wound-protection liquid film in embodiment 2；
Accompanying drawing 4 is the cytotoxicity test figure of antibacterial liquid Wound-protection liquid film in embodiment 2.
Detailed description of the invention
Below in conjunction with accompanying drawing embodiment, the present invention is further described.
Embodiment 1
The present embodiment provides a kind of antibacterial liquid Wound-protection liquid film, and it includes the component of following parts by weight:
Polyvinyl formal-acetal 25 parts,
Polyvinyl butyral resin 25 parts；
Polymethyl acrylate 1 part；
Polydimethylsiloxane 1 part；
Heptyl acetate 2 parts；
Ethanol 150 parts；
Camphora 0.5 part；
Glycerol 5 parts；
Isopropyl palmitate 10 parts；
Triclosan 0.05 part.
The preparation method of above-mentioned antibacterial liquid Wound-protection liquid film, it comprises the following steps:
A the oil-soluble polyvinyl alcohol contracting alkyl aldehydes of formula ratio, polyacrylate are dissolved in ethanol by (), add formula after stirring
Isopropyl palmitate, heptyl acetate polydimethylsiloxane and the glycerol of amount, stirring (mixing speed is 500rpm) mixing system
Obtain film liquid；
B () adds Camphora and the triclosan of formula ratio while stirring (mixing speed is 500rpm) described film liquid,
Mix ultrasonic.
Prepared product is carried out antibacterial test, cytotoxicity test, irritation test and application effect appraisal:
Antibacterial test: test this product antibiotic property to escherichia coli, staphylococcus aureus and Candida albicans.Take this respectively
Product, is coated on 1.5cm2Glass surface, and with blank glass as a control group, drip respectively at experimental group and matched group surface
Add the bacterium solution (comprising escherichia coli, staphylococcus aureus and Candida albicans) of OD=0.1, coated plate after cultivating 4 hours, then train
Counting after supporting 24 hours, its antibiotic property is as it is shown in figure 1, illustrate that escherichia coli, staphylococcus aureus and white are read by this product
Pearl bacterium is respectively provided with the antibiotic property of excellence.
Cytotoxicity is tested: utilize MTT(3-(4,5-dimethylthiazole-2)-2,5-diphenyltetrazolium bromide bromide) method antagonism
The toxicity of human dermal fibroblasts is tested by the liquid film of bacterium adhesive bandage.By human dermal fibroblasts (1 × 104
CFU/ml) in 24 orifice plates, cultivate 48 h by 10% hyclone culture medium, take 1.0 × 1.0 cm respectively2It is coated with antimicrobial fluid
The glass of body adhesive bandage film and the glass of uncoated join in human dermal fibroblasts's solution and cultivate at 37 DEG C, after 72h
Take 0.1 mL MTT solution (5 g/L PBS solution) respectively to drop to orifice plate is further cultured for, after 4h, supernatant in orifice plate is moved
Remove, and add 0.75 mL DMSO and test its OD to dissolve first a ceremonial jade-ladle, used in libation crystal microplate reader490 nmValue characterizes the burst size of first a ceremonial jade-ladle, used in libation,
Parallel laboratory test 3 times, the relative growth rate of test human dermal fibroblasts, its cytotoxicity is as in figure 2 it is shown, illustrate this product
Product the most do not have obvious cytotoxicity to fibroblast.
Irritation test: observe this product skin irritation to mice.Method: this product is respectively with every square li
Silverskin skin 0.05g, 0.1g, 0.15g make single and repeatedly intact skin and injured skin irritation test respectively to mice, are painted with
After this product, according to the form below 1 skin wound repair standards of grading calculate integral mean value, and make the inspection of recipient site histopathology of skin
Look into.This product single or multiple contact wounds in mice, its histopathology of skin checks with blank group without significant difference, skin
The scoring of skin irritative response is zero, shows that this product, in a short time to mice nonirritant, is safe for locally or systemically skin.
Table 1 skin wound repair standards of grading
| Dermoreaction | Integration |
| Erythema and eschar are formed | |
| Without erythema | 0 |
| Slight erythema | 1 |
| Substantially erythema | 2 |
| Slightly form a scab formation | 1 |
| Edema is formed | |
| Without edema | 0 |
| Slight edema | 1 |
| Intermediate edema | 2 |
| Severe edema | 0 |
Embodiment 2
The present embodiment provides a kind of antibacterial liquid Wound-protection liquid, basically identical, except for the difference that with embodiment 1 of its preparation method:
It includes the component of following parts by weight,
Polyvinyl formal-acetal 5 parts；
Polyethyl acrylate 5 parts；
Polydimethylsiloxane 5 parts；
Heptyl acetate 5 parts；
Ethanol 200 parts；
Camphora 1.5 parts；
Glycerol 10 parts；
Isopropyl palmitate 20 parts；
Triclosan 0.2 part.
Its antibacterial test and cytotoxicity test are the most as shown in Figure 3, Figure 4.
Embodiment 3
The present embodiment provides a kind of antibacterial liquid Wound-protection liquid, basically identical, except for the difference that with embodiment 1 of its preparation method:
It includes the component of following parts by weight,
Polyvinyl formal-acetal 45 parts；
Butyl polyacrylate 2 parts；
Polydimethylsiloxane 1.5 parts；
Heptyl acetate 1 part；
Ethanol 160 parts；
Camphora 0.8 part；
Glycerol 6 parts；
Isopropyl palmitate 12 parts；
Triclosan 0.1 part.
It is carried out antibacterial test, records the survival rate of escherichia coli, staphylococcus aureus and Candida albicans respectively
It is 5%, 3%, 6%.
Embodiment 4
The present embodiment provides a kind of antibacterial liquid Wound-protection liquid, basically identical, except for the difference that with embodiment 1 of its preparation method:
It includes the component of following parts by weight,
Polyvinyl formal-acetal 10 parts；
Polyethyl acrylate 4 parts；
Polydimethylsiloxane 5 parts；
Heptyl acetate 5 parts；
Ethanol 190 parts；
Camphora 1.2 parts；
Glycerol 8 parts；
Isopropyl palmitate 18 parts；
Triclosan 0.18 part.
It is carried out antibacterial test, records the survival rate of escherichia coli, staphylococcus aureus and Candida albicans respectively
It is 3%, 5%, 3%.
Embodiment 5
The present embodiment provides a kind of antibacterial liquid Wound-protection liquid, basically identical, except for the difference that with embodiment 1 of its preparation method:
It includes the component of following parts by weight,
Oil-soluble polyvinyl alcohol contracting alkyl aldehydes 20 parts；
Polyacrylate 3 parts；
Polydimethylsiloxane 3 parts；
Heptyl acetate 3 parts；
Ethanol 170 parts；
Camphora 1 part；
Glycerol 7 parts；
Isopropyl palmitate 5 parts；
Triclosan 0.15 part.
It is carried out antibacterial test, records the survival rate of escherichia coli, staphylococcus aureus and Candida albicans respectively
It is 5%, 6%, 8%.
Above-described embodiment, only for technology design and the feature of the explanation present invention, its object is to allow person skilled in the art
Scholar will appreciate that present disclosure and implements according to this, can not limit the scope of the invention with this, all according to the present invention
The equivalence that spirit is made changes or modifies, and all should contain within protection scope of the present invention.
Claims (4)
1. an antibacterial liquid Wound-protection liquid film, it is characterised in that it includes the component of following parts by weight:
Oil-soluble polyvinyl alcohol contracting alkyl aldehydes 5 ~ 50 parts；
Polyacrylate 1 ~ 5 part；
Polydimethylsiloxane 1 ~ 5 part；
Heptyl acetate 1 ~ 5 part；
Ethanol 150 ~ 200 parts；
Camphora 0.5 ~ 1.5 part；
Glycerol 5 ~ 10 parts；
Isopropyl palmitate 10 ~ 20 parts；
Triclosan 0.05 ~ 0.2 part.
Antibacterial liquid Wound-protection liquid film the most according to claim 1, it is characterised in that: described oil-soluble polyvinyl alcohol contracting alkyl
Aldehyde is the mixing of one or more compositions in polyvinyl butyral resin, polyvinyl formal and polyvinyl formal-acetal
Thing.
Antibacterial liquid Wound-protection liquid film the most according to claim 1, it is characterised in that: described polyacrylate is polyacrylic acid
The mixture of one or more compositions in methyl ester, polyethyl acrylate and butyl polyacrylate.
4. the preparation method of arbitrary described antibacterial liquid Wound-protection liquid film in claims 1 to 3, it is characterised in that it includes following
Step:
A the oil-soluble polyvinyl alcohol contracting alkyl aldehydes of formula ratio, polyacrylate are dissolved in ethanol by (), add formula after stirring
Isopropyl palmitate, heptyl acetate, polydimethylsiloxane and the glycerol of amount, stirring is mixed to prepare film liquid；
B () adds Camphora and the triclosan of formula ratio while stirring described film liquid, mix ultrasonic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610584059.9A CN106178095A (en) | 2016-07-22 | 2016-07-22 | A kind of antibacterial liquid Wound-protection liquid film and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610584059.9A CN106178095A (en) | 2016-07-22 | 2016-07-22 | A kind of antibacterial liquid Wound-protection liquid film and preparation method thereof |
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| CN106178095A true CN106178095A (en) | 2016-12-07 |
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|---|---|---|---|
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108815569A (en) * | 2018-06-20 | 2018-11-16 | 北京点域科技有限公司 | A kind of medical type wound repairs the preparation method of liquid |
| CN110974810A (en) * | 2019-12-24 | 2020-04-10 | 重庆铭仁堂医疗科技有限公司 | Film-forming wound protecting liquid and preparation method and application thereof |
| CN112165960A (en) * | 2018-04-06 | 2021-01-01 | 佩利斯护理有限公司 | Composition for treating chronic wounds |
| CN114306729A (en) * | 2022-03-15 | 2022-04-12 | 中国人民解放军总医院第一医学中心 | Biological antibacterial film-forming liquid medical dressing and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1647804A (en) * | 2004-01-20 | 2005-08-03 | 北京东方凯恩医药科技有限公司 | External medicine spray |
| CN102406959A (en) * | 2011-11-29 | 2012-04-11 | 江苏德达医药科技有限公司 | Liquid bandage containing povidone iodine and preparation method thereof |
| CN105363066A (en) * | 2015-11-30 | 2016-03-02 | 江苏华能药业有限公司 | Liquid band-aid |
-
2016
- 2016-07-22 CN CN201610584059.9A patent/CN106178095A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1647804A (en) * | 2004-01-20 | 2005-08-03 | 北京东方凯恩医药科技有限公司 | External medicine spray |
| CN102406959A (en) * | 2011-11-29 | 2012-04-11 | 江苏德达医药科技有限公司 | Liquid bandage containing povidone iodine and preparation method thereof |
| CN105363066A (en) * | 2015-11-30 | 2016-03-02 | 江苏华能药业有限公司 | Liquid band-aid |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112165960A (en) * | 2018-04-06 | 2021-01-01 | 佩利斯护理有限公司 | Composition for treating chronic wounds |
| CN108815569A (en) * | 2018-06-20 | 2018-11-16 | 北京点域科技有限公司 | A kind of medical type wound repairs the preparation method of liquid |
| CN110974810A (en) * | 2019-12-24 | 2020-04-10 | 重庆铭仁堂医疗科技有限公司 | Film-forming wound protecting liquid and preparation method and application thereof |
| CN110974810B (en) * | 2019-12-24 | 2023-10-17 | 重庆铭仁堂怡和中医诊所有限公司 | Film-forming wound protection liquid and preparation method and application thereof |
| CN114306729A (en) * | 2022-03-15 | 2022-04-12 | 中国人民解放军总医院第一医学中心 | Biological antibacterial film-forming liquid medical dressing and preparation method thereof |
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Application publication date: 20161207 |