CN108815569A - A kind of medical type wound repairs the preparation method of liquid - Google Patents
A kind of medical type wound repairs the preparation method of liquid Download PDFInfo
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- CN108815569A CN108815569A CN201810639596.8A CN201810639596A CN108815569A CN 108815569 A CN108815569 A CN 108815569A CN 201810639596 A CN201810639596 A CN 201810639596A CN 108815569 A CN108815569 A CN 108815569A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/14—Methyl esters, e.g. methyl (meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
- C08F220/1804—C4-(meth)acrylate, e.g. butyl (meth)acrylate, isobutyl (meth)acrylate or tert-butyl (meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
- C08F220/1808—C8-(meth)acrylate, e.g. isooctyl (meth)acrylate or 2-ethylhexyl (meth)acrylate
Abstract
The invention belongs to medical material technical fields, and in particular to a kind of medical type wound repairs the preparation method of liquid.The preparation method that the medical type wound repairs liquid is, in desinfection chamber, mixed solvent is added in a kettle, 40-45 parts of mass fraction meter of methylpropanoic acid acid methyl esters, 1-2 parts of acrylic acid, the lower acrylic ester monomer of 40-42 parts of glass transition temperature, the acrylic ester monomer of 2-3 parts of hydroxyl, 0.3-0.5 parts of initiator, after reacting 4h, acrylic ester monomer and 2-3 parts of the Isooctyl acrylate monomer that 1 part of hydroxyl is added dropwise are mixed, react 2h, 30 DEG C of cooling, 4-5 parts of mixed liquor one and 0.5 part of hydrogen peroxide is added, stop reaction after mixing 15 minutes, obtain a kind of medical type wound reparation liquid；By the modification to polyvinyl alcohol, the silicon dioxide granule of essential oil has been adsorbed by its cladding, has made it have the effect of sustained release essential oil, and the proportion by adjusting acrylic ester monomer, and the monomer with skin-friendly is added, keeps it good with the adhesive property of skin.
Description
Technical field
The invention belongs to medical material technical fields, and in particular to a kind of medical type wound repairs the preparation method of liquid.
Background technique
Medical type wound repair liquid solve the problems, such as defect present in traditional bandage use and, belong to biological film-forming type
Disinfectant has many advantages, such as good waterproofness and gas permeability, easy to use.
Chinese patent application CN106110382A discloses a kind of preparation method of liquid bandage, belongs to medical technology neck
Domain includes the following steps：Step 1 prepares modification of chitosan；Step 2, take cape jasmine, Cortex Phellodendri, honeysuckle, Cortex Magnoliae Officinalis, radix saposhnikoviae, Radix Ophiopogonis,
Fructus Forsythiae, rhizoma anemarrhenae, cloves, Rhizoma Chuanxiong carry out impregnation；Step 3 prepares concentrate；Step 4, alcohol reflux extract, and obtain medicinal extract；
After being uniformly mixed concentrate and medicinal extract, modification of chitosan and alginate is added in step 5, is stirred evenly to get liquid is arrived
Bandage.The liquid bandage filming performance of invention preparation is extremely excellent, has ideal hemostasis, analgesic, sterilizes, disappears
Effect that is scorching and preventing secondary infection, but preparation cost is higher and the process is more complicated.
Chinese patent application 107468904A discloses that the invention discloses a kind of liquid bandage and preparation method thereof, institutes
Stating liquid bandage includes following components and its parts by weight：20~60 parts of radix tetrastigme extracting solution；10~50 parts of bletilla striata extract；
5~50 parts of filmogen；20~200 parts of volatile solvent；0.5~15 part of plasticizer；0.5~10 part of moisturizer；Laurel nitrogen is tall and erect
1~10 part of ketone, the liquid bandage which provides be coated on behind affected part can the surface of a wound quickly form one layer it is soft, be not easy
It falls off, nontoxic nonirritant skin sparing film, have the function of hemostasis, prevent wound infection, waterproof etc., but the invention is bonded
Performance is inadequate, and usage amount is larger.
But existing liquid bandage all cannot persistently effectively repair wound well, therefore research and develop one kind
It repairs persistently, the good bandage of filming performance is particularly important.
Summary of the invention
In order to achieve the purpose that in background technique, a kind of preparation method of medical type wound reparation liquid proposed by the present invention；
By the modification to polyvinyl alcohol, the silicon dioxide granule of essential oil has been adsorbed by its cladding, has made it have the work of sustained release essential oil
With, and the proportion by adjusting acrylic ester monomer, the monomer with skin-friendly is added, makes its adhesive property with skin
It is good.
What the present invention realized by the following technical solutions
A kind of medical type wound repairs the preparation method of liquid, which is characterized in that the medical type wound repairs the system of liquid
Preparation Method is：
(1) Rosa Damascana is dispersed in nano silica, then gathers the silica for having adsorbed essential oil with modified
Glycohol solution stirring, is made mixed liquor one；
(2) in desinfection chamber, control temperature of reaction kettle is 70 DEG C, revolving speed 200rpm, and 100 parts are added in a kettle
Mass ratio is 95：5 ethyl alcohol and ethyl acetate mixed solvent, and by 40-45 parts of mass fraction meter of methylpropanoic acid acid methyl esters, 1-
The acrylic acid of the lower acrylic ester monomer of 2 parts of acrylic acid, 40-42 parts of glass transition temperature, 2-3 parts of hydroxyl
Esters monomer, 0.3-0.5 parts of initiator after mixing, takes 1/8 mixed liquor in reaction kettle, after reacting 1h, is added dropwise remaining
Mixed liquor is controlled and is added dropwise to complete in 1h, and after isothermal reaction 4h, the esters of acrylic acid list of 1 part of hydroxyl is added dropwise with the speed of 1s/ drop
Body, 2-3 parts of Isooctyl acrylate monomer mixed liquor, heat up 5 DEG C of reaction 2h after being added dropwise to complete, and then cools the temperature to 30 DEG C, on one side
4-5 parts of mixed liquor one is added, on one side with speed 0.5 part of hydrogen peroxide of addition of 3s/ drop with the speed of 1s/ drop, mixes 15 minutes
Stop reaction afterwards, be cooled to room temperature, obtains a kind of medical type wound reparation liquid.
Further, the modified polyvinylalcohol preparation method is that in desinfection chamber, control temperature of reaction kettle is 75 DEG C,
Revolving speed is 200rpm, by 20-25 parts of mass fraction meter of polyvinyl alcohol ultrasonic disperse 15 parts mass ratio be 12：3 ethyl alcohol
With ethyl acetate in the mixed solvent, and the acrylic ester monomer of 1-2 parts of acrylic acid, 1-2 parts of hydroxyls is added, carries out high-speed stirring
It after mixing 1-2h, is cooled to room temperature taking-up and is sealed preservation, this substance is exactly a kind of modified polyvinylalcohol.
Further, the mixed liquor one is prepared as, and at room temperature, 2-3 parts of Rosa Damascana ultrasonic disperse is being received
In rice silica, for 24 hours, filter residue is added in modified poly ethylene alcoholic solution staticaccelerator adsorption by filtering, and filtrate can be used for next time
Adsorption process stirs 15 minutes, obtains mixed liquor one.
Further, the lower acrylic ester monomer of the glass transition temperature is ethyl acrylate, acrylic acid fourth
One or more of ester, Isooctyl acrylate monomer.
Further, the acrylic ester monomer of the hydroxyl is hydroxyethyl methacrylate, methacrylic acid hydroxypropyl
Ester.
Further, the solid content that the medical type wound repairs liquid must not be higher than 50%, must not be lower than 40%.
Further, it is that the glass transition temperature control of crylic acid ester mixture liquid exists that the medical type wound, which repairs liquid,
40-42℃。
Further, the solid content of the polyvinyl alcohol must not be lower than 55%.
Beneficial to benefit
1, the present invention is modified polyvinyl alcohol, can make and can preferably coat the nano-silica for having adsorbed essential oil
SiClx particle, discharges essential oil persistently, repairs to wound；
2, the present invention is modified polyvinyl alcohol, keeps it more preferable with matrix liquid phase capacitive, and skin-friendly is more preferable, rises to wound
To preferably as effect；
3, simple production process of the present invention, raw material are cheap.
Specific embodiment
In order to keep the purpose of the present invention, technical scheme and beneficial effects clearer, below in conjunction with experimental data, to this
The preferred embodiment of invention is described in detail, to facilitate the technical staff to understand.
Embodiment 1
The preparation method that a kind of medical type wound repairs liquid includes the following steps：
(1) at room temperature, by 3 parts of Rosa Damascana ultrasonic disperse in nano silica, staticaccelerator adsorption for 24 hours, is filtered
Filter residue is added in modified poly ethylene alcoholic solution, filtrate can be used for adsorption process next time, stirs 15 minutes, obtains mixed liquor
One.
(2) in desinfection chamber, control temperature of reaction kettle is 75 DEG C, revolving speed 200rpm, by 23 parts of mass fraction meter gather
Vinyl alcohol ultrasonic disperse is 12 in 15 parts of mass ratio：3 ethyl alcohol and ethyl acetate in the mixed solvent, and 1.5 parts of propylene are added
Sour, 1.5 parts of hydroxyls acrylic ester monomers are cooled to room temperature taking-up and are sealed preservation after carrying out high-speed stirred 1-2h,
This substance is exactly a kind of modified polyvinylalcohol.
(3) in desinfection chamber, control temperature of reaction kettle is 70 DEG C, revolving speed 200rpm, and 100 parts are added in a kettle
Mass ratio is 95：5 ethyl alcohol and ethyl acetate mixed solvent, and by 45 parts of mass fraction meter of methylpropanoic acid acid methyl esters, 1-2 parts
Acrylic acid, the lower acrylic ester monomer of 40-42 parts of glass transition temperature, 2-3 parts of hydroxyl acrylate
Class monomer, 0.35 part of initiator after mixing, take 1/8 mixed liquor in reaction kettle, and after reacting 1h, remaining mixing is added dropwise
Liquid is controlled and is added dropwise to complete in 1h, after isothermal reaction 4h, with the acrylic ester monomer of the speed of 1s/ drop 1 part of hydroxyl of dropwise addition,
2.5 parts of Isooctyl acrylate monomer mixed liquor, after being added dropwise to complete heat up 5 DEG C of reaction 2h, then cool the temperature to 30 DEG C, on one side with
4.5 parts of mixed liquor one is added, on one side with speed 0.5 part of hydrogen peroxide of addition of 3s/ drop in the speed of 1s/ drop, after mixing 15 minutes
Stop reaction, be cooled to room temperature, obtains a kind of medical type wound reparation liquid.
Embodiment 2
The preparation method that a kind of medical type wound repairs liquid includes the following steps：
(1) at room temperature, by 3 parts of Rosa Damascana ultrasonic disperse in nano silica, staticaccelerator adsorption for 24 hours, is filtered
Filter residue is added in modified poly ethylene alcoholic solution, filtrate can be used for adsorption process next time, stirs 15 minutes, obtains mixed liquor
One.
(2) in desinfection chamber, control temperature of reaction kettle is 75 DEG C, revolving speed 200rpm, by 25 parts of mass fraction meter gather
Vinyl alcohol ultrasonic disperse is 12 in 15 parts of mass ratio：3 ethyl alcohol and ethyl acetate in the mixed solvent, and 2 parts of acrylic acid of addition,
The acrylic ester monomer of 1 part of hydroxyl is cooled to room temperature taking-up and is sealed preservation after carrying out high-speed stirred 1-2h, this object
Matter is exactly a kind of modified polyvinylalcohol.
(3) in desinfection chamber, control temperature of reaction kettle is 70 DEG C, revolving speed 200rpm, and 100 parts are added in a kettle
Mass ratio is 95：5 ethyl alcohol and ethyl acetate mixed solvent, and by 43 parts of mass fraction meter of methylpropanoic acid acid methyl esters, 1.5 parts
Acrylic acid, the lower acrylic ester monomer of 42 parts of glass transition temperature, 3 parts of hydroxyl esters of acrylic acid list
Body, 0.3 part of initiator after mixing, take 1/8 mixed liquor in reaction kettle, and after reacting 1h, residual mixed liquor, control is added dropwise
Be added dropwise to complete in 1h, after isothermal reaction 4h, with the speed of 1s/ drop be added dropwise 1 part of hydroxyl acrylic ester monomer, 2.5 parts
Isooctyl acrylate monomer mixed liquor, heat up 5 DEG C of reaction 2h after being added dropwise to complete, and 30 DEG C is then cooled the temperature to, on one side with the speed of 1s/ drop
4.5 parts of mixed liquor one is added, on one side with speed 0.5 part of hydrogen peroxide of addition of 3s/ drop in degree, stops reaction after mixing 15 minutes,
It is cooled to room temperature, obtains a kind of medical type wound reparation liquid.
Embodiment 3
The preparation method that a kind of medical type wound repairs liquid includes the following steps：
(1) at room temperature, by 3 parts of Rosa Damascana ultrasonic disperse in nano silica, staticaccelerator adsorption for 24 hours, is filtered
Filter residue is added in modified poly ethylene alcoholic solution, filtrate can be used for adsorption process next time, stirs 15 minutes, obtains mixed liquor
One.
(2) in desinfection chamber, control temperature of reaction kettle is 75 DEG C, revolving speed 200rpm, by 22 parts of mass fraction meter gather
Vinyl alcohol ultrasonic disperse is 12 in 15 parts of mass ratio：3 ethyl alcohol and ethyl acetate in the mixed solvent, and 1.2 parts of propylene are added
Sour, 1.2 parts of hydroxyls acrylic ester monomers are cooled to room temperature taking-up and are sealed preservation after carrying out high-speed stirred 2h, this
Substance is exactly a kind of modified polyvinylalcohol.
(3) in desinfection chamber, control temperature of reaction kettle is 70 DEG C, revolving speed 200rpm, and 100 parts are added in a kettle
Mass ratio is 95：5 ethyl alcohol and ethyl acetate mixed solvent, and by 40 parts of mass fraction meter of methylpropanoic acid acid methyl esters, 2 parts
Acrylic acid, the lower acrylic ester monomer of 42 parts of glass transition temperature, 3 parts of hydroxyl acrylic ester monomer,
0.4 part of initiator after mixing, takes 1/8 mixed liquor in reaction kettle, and after reacting 1h, residual mixed liquor is added dropwise, controls 1h
It is inside added dropwise to complete, after isothermal reaction 4h, acrylic ester monomer, 3 parts of the propylene of 1 part of hydroxyl is added dropwise with the speed of 1s/ drop
The different monooctyl ester mixed liquor of acid, heat up 5 DEG C of reaction 2h after being added dropwise to complete, and then cools the temperature to 30 DEG C, is added on one side with the speed of 1s/ drop
Enter 4 parts of mixed liquor one, on one side with speed 0.5 part of hydrogen peroxide of addition of 3s/ drop, stops reaction after mixing 15 minutes, be cooled to
Room temperature obtains a kind of medical type wound reparation liquid.
Embodiment 4
The preparation method that a kind of medical type wound repairs liquid includes the following steps：
(1) at room temperature, by 3 parts of Rosa Damascana ultrasonic disperse in nano silica, staticaccelerator adsorption for 24 hours, is filtered
Filter residue is added in modified poly ethylene alcoholic solution, filtrate can be used for adsorption process next time, stirs 15 minutes, obtains mixed liquor
One.
(2) in desinfection chamber, control temperature of reaction kettle is 75 DEG C, revolving speed 200rpm, by 23 parts of mass fraction meter gather
Vinyl alcohol ultrasonic disperse is 12 in 15 parts of mass ratio：3 ethyl alcohol and ethyl acetate in the mixed solvent, and 1.2 parts of propylene are added
Sour, 1.8 parts of hydroxyls acrylic ester monomers are cooled to room temperature taking-up and are sealed preservation after carrying out high-speed stirred 2h, this
Substance is exactly a kind of modified polyvinylalcohol.
(3) in desinfection chamber, control temperature of reaction kettle is 70 DEG C, revolving speed 200rpm, and 100 parts are added in a kettle
Mass ratio is 95：5 ethyl alcohol and ethyl acetate mixed solvent, and by 43 parts of mass fraction meter of methylpropanoic acid acid methyl esters, 2 parts
Acrylic acid, the lower acrylic ester monomer of 40 parts of glass transition temperature, 3 parts of hydroxyl acrylic ester monomer,
0.3 part of initiator after mixing, takes 1/8 mixed liquor in reaction kettle, and after reacting 1h, residual mixed liquor is added dropwise, controls 1h
It is inside added dropwise to complete, after isothermal reaction 4h, with the acrylic ester monomer of speed 1 part of hydroxyl of dropwise addition of 1s/ drop, the third of 2-3 parts
The different monooctyl ester mixed liquor of olefin(e) acid, heat up 5 DEG C of reaction 2h after being added dropwise to complete, and 30 DEG C is then cooled the temperature to, on one side with the speed of 1s/ drop
5 parts of mixed liquor one is added, on one side with speed 0.5 part of hydrogen peroxide of addition of 3s/ drop, stops reaction after mixing 15 minutes, it is cooling
To room temperature, a kind of medical type wound reparation liquid is obtained.
Experimental analysis：
1, peel strength is tested
Medical type wound prepared by embodiment 1-4 repairs liquid and commercially available medical type wound repairs liquid and carries out peel strength
Test, testing result are as shown in the table：
Above-mentioned test result is it is found that medical type wound prepared by the present invention reparation liquid peel strength is big, with skin cementability
Can be strong, this can reduce the usage amount for repairing liquid.
2, cost compares
1-4 cost of the embodiment of the present invention is respectively 25-30 Yuan/㎏, 25-30 Yuan/㎏, 26-32 Yuan/㎏, 25-30 Yuan/㎏,
And it is 32-50 Yuan/㎏ that medical type wound, which repairs liquid, therefore, product price of the invention is cheap, and it is raw to can be used for extensive batch
It produces.
Finally, it is stated that preferred embodiment above is only used to illustrate the technical scheme of the present invention rather than limits, although logical
It crosses above preferred embodiment the present invention is described in detail, however, those skilled in the art should understand that, can be
Various changes are made to it in form and in details, without departing from defined by claims of the present invention.
Claims (8)
1. the preparation method that a kind of medical type wound repairs liquid, which is characterized in that the medical type wound repairs the preparation of liquid
Method is：
(1) Rosa Damascana is dispersed in nano silica, then will have adsorbed the silica and modified poly ethylene of essential oil
Alcoholic solution stirring, is made mixed liquor one；
(2) in desinfection chamber, control temperature of reaction kettle is 70 DEG C, revolving speed 200rpm, and 100 parts of quality is added in a kettle
Than being 95：5 ethyl alcohol and ethyl acetate mixed solvent, and by 40-45 parts of mass fraction meter of methylpropanoic acid acid methyl esters, 1-2 parts
Acrylic acid, the lower acrylic ester monomer of 40-42 parts of glass transition temperature, 2-3 parts of hydroxyl acrylate
Class monomer, 0.3-0.5 parts of initiator after mixing, takes 1/8 mixed liquor in reaction kettle, after reacting 1h, is added dropwise remaining mixed
Liquid is closed, controls and is added dropwise to complete in 1h, after isothermal reaction 4h, the esters of acrylic acid list of 1 part of hydroxyl is added dropwise with the speed of 1s/ drop
Body, 2-3 parts of Isooctyl acrylate monomer mixed liquor, heat up 5 DEG C of reaction 2h after being added dropwise to complete, and then cools the temperature to 30 DEG C, on one side
4-5 parts of mixed liquor one is added, on one side with speed 0.5 part of hydrogen peroxide of addition of 3s/ drop with the speed of 1s/ drop, mixes 15 minutes
Stop reaction afterwards, be cooled to room temperature, obtains a kind of medical type wound reparation liquid.
2. the preparation method that a kind of medical type wound according to claim 1 repairs liquid, which is characterized in that the modification
Polyvinyl alcohol preparation method is, in desinfection chamber, control temperature of reaction kettle is 75 DEG C, revolving speed 200rpm, by mass fraction meter
20-25 parts of polyvinyl alcohol ultrasonic disperse is 12 in 15 parts of mass ratio：3 ethyl alcohol and ethyl acetate in the mixed solvent, and add
Enter the acrylic ester monomer of 1-2 parts of acrylic acid, 1-2 parts of hydroxyls, after carrying out high-speed stirred 1-2h, be cooled to room temperature take out into
Row is sealed, this substance is exactly a kind of modified polyvinylalcohol.
3. the preparation method that a kind of medical type wound according to claim 1 repairs liquid, which is characterized in that the mixing
Liquid one is prepared as, at room temperature, by 2-3 parts of Rosa Damascana ultrasonic disperse in nano silica, staticaccelerator adsorption for 24 hours,
Filter residue is added in modified poly ethylene alcoholic solution by filtering, and filtrate can be used for adsorption process next time, is stirred 15 minutes, is mixed
Close liquid one.
4. the preparation method that a kind of medical type wound according to claim 1 repairs liquid, which is characterized in that the glass
Change the lower acrylic ester monomer of transition temperature be, one of ethyl acrylate, butyl acrylate, Isooctyl acrylate monomer or
It is several.
5. the preparation method that a kind of medical type wound according to claim 1 repairs liquid, which is characterized in that described contains hydroxyl
The acrylic ester monomer of base is hydroxyethyl methacrylate, hydroxy propyl methacrylate.
6. the preparation method that a kind of medical type wound according to claim 1 repairs liquid, which is characterized in that described is medical
The solid content that type wound repairs liquid must not be higher than 50%, must not be lower than 40%.
7. the preparation method that a kind of medical type wound according to claim 2 repairs liquid, which is characterized in that described is medical
Type wound repairs liquid, and the glass transition temperature of crylic acid ester mixture liquid is controlled at 40-42 DEG C.
8. the preparation method that a kind of medical type wound according to claim 3 repairs liquid, which is characterized in that the poly- second
The solid content of enol must not be lower than 55%.
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