CN108434503A - A kind of environment-friendly type medical dressing of antibacterial hemostasis and preparation method thereof - Google Patents
A kind of environment-friendly type medical dressing of antibacterial hemostasis and preparation method thereof Download PDFInfo
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- CN108434503A CN108434503A CN201810504263.4A CN201810504263A CN108434503A CN 108434503 A CN108434503 A CN 108434503A CN 201810504263 A CN201810504263 A CN 201810504263A CN 108434503 A CN108434503 A CN 108434503A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
Abstract
The invention discloses a kind of environment-friendly type medical dressing of antibacterial hemostasis, the medical dressing is using the medical cloth of carbon fiber as base fabric, having nano-titanium oxide/chitosan microball composite layer, sodium alginate glue-line, hemostatic layer, the hemostatic layer above base fabric successively is prepared by Chinese herbal medicine extract.The invention also discloses the preparation methods of the environmental protection medical dressing.Medical dressing produced by the present invention has good antibacterial haemostatic effect, can effectively facilitate wound healing, improves healing quality, prepares simply, at low cost.
Description
Technical field：
The present invention relates to field of medical materials, are specifically related to a kind of environment-friendly type medical dressing of antibacterial hemostasis.
Background technology：
In daily life, there are many type of wound, including burn caused by the factors such as machinery, electricity, heat, chemistry, Yi Jiyou
In the morphogenetic chronic trauma of the physiological disease of patient.Medical dressing be a kind of flap coverage, assist wound healing material.Cotton yarn
Cloth is China's production and the maximum medical dressing of usage amount.In terms of service condition, cotton yarn is furnished with higher imbibition ability, can make liquid
Body is uniformly distributed in monoblock gauze, prevents local hydrops from generating, but cotton gauze is easily dry, can be from wound surface in removal
Some vital tissues under adhesion, prodigious pain is brought to patient.
Currently, the main direction of studying about medical dressing be mainly improve dressing with the compatibility of the surface of a wound, antibiotic property with
And biodegradable properties etc..
Invention content：
The object of the present invention is to provide a kind of environment-friendly type medical dressing of antibacterial hemostasis, and the medical dressing skin-friendly is good, suppression
Bacterium haemostatic effect is good, can effectively facilitate wound healing, improves healing quality.
It is a further object to provide the preparation methods of the environment-friendly type medical dressing.
To achieve the above object, the present invention uses following technical scheme：
A kind of environment-friendly type medical dressing of antibacterial hemostasis, the medical dressing is using the medical cloth of carbon fiber as base fabric, above base fabric
Having nano-titanium oxide/chitosan microball composite layer, sodium alginate glue-line, hemostatic layer, the hemostatic layer successively is carried by Chinese herbal medicine
Object is taken to be prepared.
A kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis, includes the following steps：
(1) chitosan is dissolved in acetic acid solution, chitosan solution is made；Then atoleine and silane coupling agent are mixed
Stirring obtained solution is closed, chitosan solution is then added and is stirred 30-50min, butyl titanate, quality then is added dropwise simultaneously
A concentration of 5% glutaraldehyde solution is warming up to 50-60 DEG C after completion of dropwise addition, stir 1-2h, be cooled to room temperature, and filters, and precipitation is washed
It is dry after washing, nano-titanium oxide/chitosan microball composite material is made；
(2) nano-titanium oxide obtained above/chitosan microball composite material is scattered in nanometer hectorite solution and is stirred
It mixes and slurry is made after mixing, slurry obtained is coated on the medical cloth surface of carbon fiber, it is dry, obtained nano-titanium oxide/
Chitosan microball composite layer；
(3) sodium alginate is dissolved in deionized water, sodium alginate soln is made, be then coated with surface nano oxidized
The carbon fiber of titanium/chitosan microball composite layer is medical to be arranged in sodium alginate soln, stewing process 3-5h, is taken out, dry；
(4) by Radix Notoginseng powder, cacumen biotae, rhizoma imperatae drying and crushing, mixed-powder is made, is then added ethyl alcohol, at 50-60 DEG C
Refluxing extraction 1-2h, is cooled to room temperature, filtering, collects filtrate, and ethyl alcohol, which is added, in filter residue continues to extract, and 2-3 times repeatedly, merges
Extracts of Chinese herbal medicine is made in filtrate；
(5) extracts of Chinese herbal medicine is sprayed to sodium alginate film surface by way of spraying, it is dry, Medical coating is made
Material.
As a preferred embodiment of the above technical solution, in step (1), the mass concentration of the acetic acid solution is 3-6%.
As a preferred embodiment of the above technical solution, in step (1), atoleine, silane coupling agent, chitosan mass ratio be
10：(0.01-0.03)：1.
As a preferred embodiment of the above technical solution, in step (1), butyl titanate, glutaraldehyde solution volume ratio be 1：
(15-30)。
As a preferred embodiment of the above technical solution, in step (1), the nano-titanium oxide, chitosan mass ratio be 1：(3-
5)。
As a preferred embodiment of the above technical solution, in step (2), the mass concentration of the nanometer hectorite solution is 1-3%.
As a preferred embodiment of the above technical solution, in step (2), nano-titanium oxide/chitosan microball composite material and nanometer
The mass ratio of hectorite solution is (0.3-0.7)：5.
As a preferred embodiment of the above technical solution, in step (3), the mass concentration of the sodium alginate soln is 15-33%.
As a preferred embodiment of the above technical solution, in step (4), Radix Notoginseng powder, cacumen biotae, rhizoma imperatae mass ratio be (1-4)：
1：(0.5-1).
As a preferred embodiment of the above technical solution, nano-titanium oxide/chitosan microball composite material, sodium alginate, Chinese herbal medicine
The mass ratio of extract is 2：(5-8)：3.
The invention has the advantages that：
For the medical cloth of carbon fiber of the present invention as base fabric, flexibility, pro-skin performance are good, antibacterial hemostatic in order to improve its
Can, the method comprises the steps of firstly, preparing chitosan microball lotions, and butyl titanate, glutaraldehyde solution then is added simultaneously, is received obtained
Rice titanium oxide is effectively crosslinked with chitosan microball, and nano-titanium oxide/chitosan microball composite material of excellent in stability is made,
Good dispersion, surface have more hydroxyl isoreactivity group, are scattered in nanometer hectorite solution, and nano-titanium oxide/
Chitosan microball composite material could be formed with effect crosslinking with nanometer hectorite, and uniform protection is formed in composite material surface
Film can be effectively bonded and the medical cloth surface of carbon fiber；
The present invention prepares one layer of sodium alginate glue-line by the method for dipping on nano-titanium oxide/chitosan surface, then
One layer of Chinese herbal medicine extract layer, medical dressing skin-friendly obtained are coated in sodium alginate film surface using the method for spraying
Good, antibacterial anthemorrhagic performance is good, can effectively facilitate wound healing.
Specific implementation mode：
In order to better understand the present invention, below by embodiment, the present invention is further described, and embodiment is served only for solving
The present invention is released, any restriction will not be constituted to the present invention.
Embodiment 1
A kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis, includes the following steps：
(1) chitosan is dissolved in the acetic acid solution that mass concentration is 3%, chitosan solution is made；Then by liquid stone
Obtained solution is mixed in wax and silane coupling agent, and chitosan solution is then added and is stirred 30min, titanium then is added dropwise simultaneously
Sour four butyl esters, the glutaraldehyde solution that mass concentration is 5%, are warming up to 50-60 DEG C, stir 1h, be cooled to room temperature after completion of dropwise addition,
Filtering, it is dry after washing of precipitate, nano-titanium oxide/chitosan microball composite material is made；Wherein, atoleine, silane coupled
Agent, chitosan mass ratio be 10：0.01：1；Butyl titanate, glutaraldehyde solution volume ratio be 1：15；Nano-titanium oxide,
The mass ratio of chitosan is 1：3；
(2) nano-titanium oxide obtained above/chitosan microball composite material is scattered in the nanometer that mass concentration is 1%
Slurry is made after being uniformly mixed in hectorite solution, slurry obtained is coated on the medical cloth surface of carbon fiber, dry, system
Obtain nano-titanium oxide/chitosan microball composite layer；Wherein, nano-titanium oxide/chitosan microball composite material and nanometer hectorite
The mass ratio of solution is 0.3：5；
(3) sodium alginate is dissolved in deionized water, the sodium alginate soln that mass concentration is 15% is made, then by table
Carbon fiber of the face coated with nano-titanium oxide/chitosan microball composite layer is medical to be arranged in sodium alginate soln, stewing process
3h takes out, dry；
(4) by Radix Notoginseng powder, cacumen biotae, rhizoma imperatae drying and crushing, mixed-powder is made, is then added ethyl alcohol, at 50-60 DEG C
Refluxing extraction 1h, is cooled to room temperature, filtering, collects filtrate, and ethyl alcohol, which is added, in filter residue continues to extract, and 2-3 times repeatedly, merges filter
Extracts of Chinese herbal medicine is made in liquid；Radix Notoginseng powder, cacumen biotae, rhizoma imperatae mass ratio be 1：1：0.5；
(5) extracts of Chinese herbal medicine is sprayed to sodium alginate film surface by way of spraying, it is dry, Medical coating is made
Material；Wherein, nano-titanium oxide/chitosan microball composite material, sodium alginate, Chinese herbal medicine extract mass ratio be 2：5：3.
Embodiment 2
A kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis, includes the following steps：
(1) chitosan is dissolved in the acetic acid solution that mass concentration is 6%, chitosan solution is made；Then by liquid stone
Obtained solution is mixed in wax and silane coupling agent, and chitosan solution is then added and is stirred 50min, titanium then is added dropwise simultaneously
Sour four butyl esters, the glutaraldehyde solution that mass concentration is 5%, are warming up to 50-60 DEG C, stir 2h, be cooled to room temperature after completion of dropwise addition,
Filtering, it is dry after washing of precipitate, nano-titanium oxide/chitosan microball composite material is made；Wherein, atoleine, silane coupled
Agent, chitosan mass ratio be 10：0.03：1；Butyl titanate, glutaraldehyde solution volume ratio be 1：30；Nano-titanium oxide,
The mass ratio of chitosan is 1：5；
(2) nano-titanium oxide obtained above/chitosan microball composite material is scattered in the nanometer that mass concentration is 3%
Slurry is made after being uniformly mixed in hectorite solution, slurry obtained is coated on the medical cloth surface of carbon fiber, dry, system
Obtain nano-titanium oxide/chitosan microball composite layer；Wherein, nano-titanium oxide/chitosan microball composite material and nanometer hectorite
The mass ratio of solution is 0.7：5；
(3) sodium alginate is dissolved in deionized water, the sodium alginate soln that mass concentration is 33% is made, then by table
Carbon fiber of the face coated with nano-titanium oxide/chitosan microball composite layer is medical to be arranged in sodium alginate soln, stewing process
5h takes out, dry；
(4) by Radix Notoginseng powder, cacumen biotae, rhizoma imperatae drying and crushing, mixed-powder is made, is then added ethyl alcohol, at 50-60 DEG C
Refluxing extraction 2h, is cooled to room temperature, filtering, collects filtrate, and ethyl alcohol, which is added, in filter residue continues to extract, and 2-3 times repeatedly, merges filter
Extracts of Chinese herbal medicine is made in liquid；Radix Notoginseng powder, cacumen biotae, rhizoma imperatae mass ratio be 4：1：1；
(5) extracts of Chinese herbal medicine is sprayed to sodium alginate film surface by way of spraying, it is dry, Medical coating is made
Material；Wherein, nano-titanium oxide/chitosan microball composite material, sodium alginate, Chinese herbal medicine extract mass ratio be 2：8：3.
Embodiment 3
A kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis, includes the following steps：
(1) chitosan is dissolved in the acetic acid solution that mass concentration is 4%, chitosan solution is made；Then by liquid stone
Obtained solution is mixed in wax and silane coupling agent, and chitosan solution is then added and is stirred 35min, titanium then is added dropwise simultaneously
Sour four butyl esters, the glutaraldehyde solution that mass concentration is 5%, are warming up to 50-60 DEG C, stir 1.2h, be cooled to room after completion of dropwise addition
Temperature, filtering is dry after washing of precipitate, and nano-titanium oxide/chitosan microball composite material is made；Wherein, atoleine, silane are even
Join agent, the mass ratio of chitosan is 10：0.015：1；Butyl titanate, glutaraldehyde solution volume ratio be 1：18；It is nano oxidized
Titanium, chitosan mass ratio be 1：3.5；
(2) nano-titanium oxide obtained above/chitosan microball composite material is scattered in the nanometer that mass concentration is 1%
Slurry is made after being uniformly mixed in hectorite solution, slurry obtained is coated on the medical cloth surface of carbon fiber, dry, system
Obtain nano-titanium oxide/chitosan microball composite layer；Wherein, nano-titanium oxide/chitosan microball composite material and nanometer hectorite
The mass ratio of solution is 0.4：5；
(3) sodium alginate is dissolved in deionized water, the sodium alginate soln that mass concentration is 20% is made, then by table
Carbon fiber of the face coated with nano-titanium oxide/chitosan microball composite layer is medical to be arranged in sodium alginate soln, stewing process
3.5h takes out, dry；
(4) by Radix Notoginseng powder, cacumen biotae, rhizoma imperatae drying and crushing, mixed-powder is made, is then added ethyl alcohol, at 50-60 DEG C
Refluxing extraction 1.2h, is cooled to room temperature, filtering, collects filtrate, and ethyl alcohol, which is added, in filter residue continues to extract, and 2-3 times repeatedly, merges
Extracts of Chinese herbal medicine is made in filtrate；Radix Notoginseng powder, cacumen biotae, rhizoma imperatae mass ratio be 2：1：0.6；
(5) extracts of Chinese herbal medicine is sprayed to sodium alginate film surface by way of spraying, it is dry, Medical coating is made
Material；Wherein, nano-titanium oxide/chitosan microball composite material, sodium alginate, Chinese herbal medicine extract mass ratio be 2：6：3.
Embodiment 4
A kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis, includes the following steps：
(1) chitosan is dissolved in the acetic acid solution that mass concentration is 4%, chitosan solution is made；Then by liquid stone
Obtained solution is mixed in wax and silane coupling agent, and chitosan solution is then added and is stirred 40min, titanium then is added dropwise simultaneously
Sour four butyl esters, the glutaraldehyde solution that mass concentration is 5%, are warming up to 50-60 DEG C, stir 1.4h, be cooled to room after completion of dropwise addition
Temperature, filtering is dry after washing of precipitate, and nano-titanium oxide/chitosan microball composite material is made；Wherein, atoleine, silane are even
Join agent, the mass ratio of chitosan is 10：0.02：1；Butyl titanate, glutaraldehyde solution volume ratio be 1：21；It is nano oxidized
Titanium, chitosan mass ratio be 1：4；
(2) it is 1.5% to receive nano-titanium oxide obtained above/chitosan microball composite material to be scattered in mass concentration
Slurry is made after being uniformly mixed in rice hectorite solution, slurry obtained is coated on the medical cloth surface of carbon fiber, it is dry,
Nano-titanium oxide/chitosan microball composite layer is made；Wherein, nano-titanium oxide/chitosan microball composite material and nanometer lithium soap
The mass ratio of stone solution is 0.5：5；
(3) sodium alginate is dissolved in deionized water, the sodium alginate soln that mass concentration is 23% is made, then by table
Carbon fiber of the face coated with nano-titanium oxide/chitosan microball composite layer is medical to be arranged in sodium alginate soln, stewing process
4h takes out, dry；
(4) by Radix Notoginseng powder, cacumen biotae, rhizoma imperatae drying and crushing, mixed-powder is made, is then added ethyl alcohol, at 50-60 DEG C
Refluxing extraction 1.4h, is cooled to room temperature, filtering, collects filtrate, and ethyl alcohol, which is added, in filter residue continues to extract, and 2-3 times repeatedly, merges
Extracts of Chinese herbal medicine is made in filtrate；Radix Notoginseng powder, cacumen biotae, rhizoma imperatae mass ratio be 2：1：0.7；
(5) extracts of Chinese herbal medicine is sprayed to sodium alginate film surface by way of spraying, it is dry, Medical coating is made
Material；Wherein, nano-titanium oxide/chitosan microball composite material, sodium alginate, Chinese herbal medicine extract mass ratio be 2：6.5：3.
Embodiment 5
A kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis, includes the following steps：
(1) chitosan is dissolved in the acetic acid solution that mass concentration is 5%, chitosan solution is made；Then by liquid stone
Obtained solution is mixed in wax and silane coupling agent, and chitosan solution is then added and is stirred 40min, titanium then is added dropwise simultaneously
Sour four butyl esters, the glutaraldehyde solution that mass concentration is 5%, are warming up to 50-60 DEG C, stir 1.6h, be cooled to room after completion of dropwise addition
Temperature, filtering is dry after washing of precipitate, and nano-titanium oxide/chitosan microball composite material is made；Wherein, atoleine, silane are even
Join agent, the mass ratio of chitosan is 10：0.02：1；Butyl titanate, glutaraldehyde solution volume ratio be 1：25；It is nano oxidized
Titanium, chitosan mass ratio be 1：4.5；
(2) it is receiving for 1-3% nano-titanium oxide obtained above/chitosan microball composite material to be scattered in mass concentration
Slurry is made after being uniformly mixed in rice hectorite solution, slurry obtained is coated on the medical cloth surface of carbon fiber, it is dry,
Nano-titanium oxide/chitosan microball composite layer is made；Wherein, nano-titanium oxide/chitosan microball composite material and nanometer lithium soap
The mass ratio of stone solution is 0.5：5；
(3) sodium alginate is dissolved in deionized water, the sodium alginate soln that mass concentration is 27% is made, then by table
Carbon fiber of the face coated with nano-titanium oxide/chitosan microball composite layer is medical to be arranged in sodium alginate soln, stewing process
4.5h takes out, dry；
(4) by Radix Notoginseng powder, cacumen biotae, rhizoma imperatae drying and crushing, mixed-powder is made, is then added ethyl alcohol, at 50-60 DEG C
Refluxing extraction 1.8h, is cooled to room temperature, filtering, collects filtrate, and ethyl alcohol, which is added, in filter residue continues to extract, and 2-3 times repeatedly, merges
Extracts of Chinese herbal medicine is made in filtrate；Radix Notoginseng powder, cacumen biotae, rhizoma imperatae mass ratio be 3.5：1：0.7；
(5) extracts of Chinese herbal medicine is sprayed to sodium alginate film surface by way of spraying, it is dry, Medical coating is made
Material；Wherein, nano-titanium oxide/chitosan microball composite material, sodium alginate, Chinese herbal medicine extract mass ratio be 2：7：3.
Embodiment 6
A kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis, includes the following steps：
(1) chitosan is dissolved in the acetic acid solution that mass concentration is 5.5%, chitosan solution is made；Then by liquid
Obtained solution is mixed in paraffin and silane coupling agent, and chitosan solution is then added and is stirred 45min, is then added dropwise simultaneously
Butyl titanate, the glutaraldehyde solution that mass concentration is 5%, are warming up to 50-60 DEG C, stir 1.8h, be cooled to after completion of dropwise addition
Room temperature, filtering is dry after washing of precipitate, and nano-titanium oxide/chitosan microball composite material is made；Wherein, atoleine, silane
Coupling agent, chitosan mass ratio be 10：0.025：1；Butyl titanate, glutaraldehyde solution volume ratio be 1：25；Nano oxygen
Change titanium, the mass ratio of chitosan is 1：4.5；
(2) nano-titanium oxide obtained above/chitosan microball composite material is scattered in the nanometer that mass concentration is 2%
Slurry is made after being uniformly mixed in hectorite solution, slurry obtained is coated on the medical cloth surface of carbon fiber, dry, system
Obtain nano-titanium oxide/chitosan microball composite layer；Wherein, nano-titanium oxide/chitosan microball composite material and nanometer hectorite
The mass ratio of solution is 0.6：5；
(3) sodium alginate is dissolved in deionized water, the sodium alginate soln that mass concentration is 30% is made, then by table
Carbon fiber of the face coated with nano-titanium oxide/chitosan microball composite layer is medical to be arranged in sodium alginate soln, stewing process
4.5h takes out, dry；
(4) by Radix Notoginseng powder, cacumen biotae, rhizoma imperatae drying and crushing, mixed-powder is made, is then added ethyl alcohol, at 50-60 DEG C
Refluxing extraction 1.8h, is cooled to room temperature, filtering, collects filtrate, and ethyl alcohol, which is added, in filter residue continues to extract, and 2-3 times repeatedly, merges
Extracts of Chinese herbal medicine is made in filtrate；Radix Notoginseng powder, cacumen biotae, rhizoma imperatae mass ratio be 3.5：1：0.9；
(5) extracts of Chinese herbal medicine is sprayed to sodium alginate film surface by way of spraying, it is dry, Medical coating is made
Material；Wherein, nano-titanium oxide/chitosan microball composite material, sodium alginate, Chinese herbal medicine extract mass ratio be 2：7.5：3.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (10)
1. a kind of environment-friendly type medical dressing of antibacterial hemostasis, it is characterised in that：The medical dressing using the medical cloth of carbon fiber as base fabric,
Have nano-titanium oxide/chitosan microball composite layer, sodium alginate glue-line, hemostatic layer above base fabric successively, the hemostatic layer be by
Chinese herbal medicine extract is prepared.
2. a kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis as described in claim 1, which is characterized in that including
Following steps：
(1) chitosan is dissolved in acetic acid solution, chitosan solution is made；Then atoleine and silane coupling agent are mixed and is stirred
Obtained solution is mixed, chitosan solution is then added and is stirred 30-50min, butyl titanate, mass concentration then is added dropwise simultaneously
For 5% glutaraldehyde solution, it is warming up to 50-60 DEG C after completion of dropwise addition, stirs 1-2h, is cooled to room temperature, filters, after washing of precipitate
It is dry, nano-titanium oxide/chitosan microball composite material is made；
(2) nano-titanium oxide obtained above/chitosan microball composite material is scattered in stir in nanometer hectorite solution and is mixed
Slurry obtained is coated on the medical cloth surface of carbon fiber by obtained slurry after closing uniformly, dry, and it is poly- that nano-titanium oxide/shell is made
Sugared microballoon composite layer；
(3) sodium alginate is dissolved in deionized water, be made sodium alginate soln, then by surface be coated with nano-titanium oxide/
The carbon fiber of chitosan microball composite layer is medical to be arranged in sodium alginate soln, stewing process 3-5h, is taken out, dry；
(4) by Radix Notoginseng powder, cacumen biotae, rhizoma imperatae drying and crushing, mixed-powder is made, ethyl alcohol is then added, flows back at 50-60 DEG C
1-2h is extracted, is cooled to room temperature, is filtered, filtrate is collected, ethyl alcohol, which is added, in filter residue continues to extract, and 2-3 times repeatedly, merges filter
Extracts of Chinese herbal medicine is made in liquid；
(5) extracts of Chinese herbal medicine is sprayed to sodium alginate film surface by way of spraying, it is dry, medical dressing is made.
3. a kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis as described in claim 1, it is characterised in that：Step
(1) in, the mass concentration of the acetic acid solution is 3-6%.
4. a kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis as described in claim 1, it is characterised in that：Step
(1) in, atoleine, silane coupling agent, chitosan mass ratio be 10：(0.01-0.03)：1.
5. a kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis as described in claim 1, it is characterised in that：Step
(1) in, butyl titanate, glutaraldehyde solution volume ratio be 1：(15-30).
6. a kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis as described in claim 1, it is characterised in that：Step
(1) in, the nano-titanium oxide, chitosan mass ratio be 1：(3-5).
7. a kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis as described in claim 1, it is characterised in that：Step
(2) in, the mass concentration of the nanometer hectorite solution is 1-3%.
8. a kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis as described in claim 1, it is characterised in that：Step
(2) in, the mass ratio of nano-titanium oxide/chitosan microball composite material and nanometer hectorite solution is (0.3-0.7)：5.
9. a kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis as described in claim 1, it is characterised in that：Step
(3) in, the mass concentration of the sodium alginate soln is 15-33%.
10. a kind of preparation method of the environment-friendly type medical dressing of antibacterial hemostasis as described in claim 1, it is characterised in that：Step
Suddenly in (4), Radix Notoginseng powder, cacumen biotae, rhizoma imperatae mass ratio be (1-4)：1：(0.5-1), nano-titanium oxide/chitosan microball are multiple
Condensation material, sodium alginate, Chinese herbal medicine extract mass ratio be 2：(5-8)：3.
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Cited By (1)
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| CN110755669A (en) * | 2019-10-31 | 2020-02-07 | 河南亚都实业有限公司 | Medical collagen wound repair membrane |
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| CN1077652A (en) * | 1993-01-02 | 1993-10-27 | 杨俊� | Medicinal dressing |
| EP0788378B1 (en) * | 1994-10-27 | 2003-01-02 | Advanced Medical Solutions Limited | Wound dressing |
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