CN101332309A - Water soluble polyose composite medical dressing and preparation method thereof - Google Patents
Water soluble polyose composite medical dressing and preparation method thereof Download PDFInfo
- Publication number
- CN101332309A CN101332309A CNA2006100009355A CN200610000935A CN101332309A CN 101332309 A CN101332309 A CN 101332309A CN A2006100009355 A CNA2006100009355 A CN A2006100009355A CN 200610000935 A CN200610000935 A CN 200610000935A CN 101332309 A CN101332309 A CN 101332309A
- Authority
- CN
- China
- Prior art keywords
- water
- soluble
- medical dressing
- polyose
- polysaccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims description 47
- 239000002131 composite material Substances 0.000 title claims description 23
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 47
- 239000005017 polysaccharide Substances 0.000 claims abstract description 47
- 150000004676 glycans Chemical class 0.000 claims abstract description 46
- 229920001661 Chitosan Polymers 0.000 claims abstract description 17
- 229920002101 Chitin Polymers 0.000 claims abstract description 16
- 229920002678 cellulose Polymers 0.000 claims abstract description 14
- 239000001913 cellulose Substances 0.000 claims abstract description 14
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 8
- 150000001875 compounds Chemical class 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 7
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 5
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 5
- 239000000661 sodium alginate Substances 0.000 claims abstract description 5
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 5
- 239000004744 fabric Substances 0.000 claims description 14
- 235000013311 vegetables Nutrition 0.000 claims description 14
- 239000004745 nonwoven fabric Substances 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 9
- 239000000443 aerosol Substances 0.000 claims description 7
- 239000000835 fiber Substances 0.000 claims description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 239000003292 glue Substances 0.000 claims description 4
- 239000011259 mixed solution Substances 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 239000003380 propellant Substances 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- 230000032050 esterification Effects 0.000 claims description 3
- 238000005886 esterification reaction Methods 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 3
- 239000000243 solution Substances 0.000 claims description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 239000012535 impurity Substances 0.000 claims description 2
- 238000001802 infusion Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 150000007524 organic acids Chemical class 0.000 claims description 2
- 238000003825 pressing Methods 0.000 claims description 2
- 238000001291 vacuum drying Methods 0.000 claims description 2
- 239000004627 regenerated cellulose Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- -1 polysaccharide compound Chemical class 0.000 abstract description 2
- 230000004913 activation Effects 0.000 abstract 3
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 230000023597 hemostasis Effects 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- AQLLBJAXUCIJSR-UHFFFAOYSA-N OC(=O)C[Na] Chemical compound OC(=O)C[Na] AQLLBJAXUCIJSR-UHFFFAOYSA-N 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000006266 etherification reaction Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention relates to a water-soluble polysaccharide compound medical dressing and a preparation method thereof; the medical dressing compounds a plant polysaccharide which has water-soluble property after the activation with an animal polysaccharide which has water-soluble property after the activation, or compounds a plant polysaccharide material or an animal polysaccharide material to form a water-soluble, natural antimicrobial compound medical dressing through the activation. The water-soluble plant polysaccharide comprises cellulose and sodium alginate after being activated and implanted; the water-soluble animal polysaccharide comprises chitin and chitosan after being activated and implanted. After being activated and implanted, the water-soluble animal polysaccharide and the water-soluble plant polysaccharide have better antibacterial effect when in a compatible use and are easy to absorb.
Description
Technical field
The present invention relates to a kind of medical dressing, especially a kind of have water solublity and a natural antibacterial medical dressing, this medical dressing can be dosage forms such as fabric, non-woven fabrics, powder, paster, diaphragm, aerosol and sponge, can be absorbed by the body, can be used for medical operating, military first aid, family's hemostasis, protect wound, have the adhesion of preventing, protect from infection, promote function such as healing.
Background technology
Existing medical dressing mostly is the material that contains vegetable polysaccharides or animal polysaccharide greatly and makes, for example vegetable polysaccharides cellulose, sodium alginate, hyaluronic acid or animal polysaccharide chitin, chitosan or the like.After the cellulose etherificate reaction,, do not possess antibacterial functions, also can shrink incrustation when being used for trauma hemostasis, cause local discomfort though hemostasis, absorption, compatibility performance are good; The use of contaminative wound surface can cause infection.For making it have antibacterial functions, usually need to add medicine, can cause side effect such as stimulation to human body.Behind the chitin etherification reaction, though have certain hemostasis, antibacterial functions, absorbability is poor, and implanting usually causes untoward reaction.
At above deficiency, produced and novel engaged the medical dressing made from the animal polysaccharide, but the water solublity of this medical dressing is not good, extremely is difficult for being absorbed by the body, and is unfavorable for treatment of diseases by vegetable polysaccharides.
Summary of the invention
The objective of the invention is at existing medical dressing because existing antibiotic property of self property or the not good deficiency of water solublity, provide a kind of that water miscible animal polysaccharide is mutually compound with vegetable polysaccharides, being convenient to of making absorbs and has strong antibiotic property simultaneously again and need not new medical dressing of dosing and preparation method thereof.
Technical scheme of the present invention is: a kind of water soluble polyose composite medical dressing, described medical dressing is with through having water miscible vegetable polysaccharides behind the overactivation and to have water miscible animal polysaccharide behind overactivation compound, or with water solublity, the natural antibacterial type based composite dressing for medical use of plant or the compound postactivated formation of animal polysaccharide material.
Preferably, described water-soluble plant polysaccharide comprises cellulose, the sodium alginate after the activated grafting; Described water soluble animal polysaccharide comprises chitin, the chitosan after the activated grafting.
Described medical dressing is to form paster on fabric, non-woven fabrics or the fiber that water miscible vegetable polysaccharides and animal polysaccharide are compounded in.
Described medical dressing is that water miscible vegetable polysaccharides and animal polysaccharide are mixed with mixed solution, is coated in the film that forms on glass or the stainless smooth surface, or the sponge that the mixed solution lyophilization is formed.
Described medical dressing is that water miscible vegetable polysaccharides and animal polysaccharide are ground into powder, adds the aerosol that propellant forms.
A kind of preparation method of water soluble polyose composite medical dressing, the fabric of water-insoluble cellulose and chitosan or fiber, non-woven fabrics will be compounded with, put into the NaOH of 10%-25%, reaction is 1-3 hour under the room temperature, press material weight subsequently than 1.0: 1.1-2.0 adds organic acid, and 20-75 ℃ was reacted 3-8 hour, and then be neutralized to pH value 5-8 in organic solvent, wash and remove impurity at last, dry to finished product.
A kind of preparation method of water soluble polyose composite medical dressing, to contain the fabric of water-soluble cellulose or non-woven fabrics or fiber and be compounded in by water-soluble glue on the fabric or non-woven fabrics or fiber that contains water-soluble chitosan or chitosan, be shaped in pressing 3-10 below 130 ℃ minute.
A kind of preparation method of water soluble polyose composite medical dressing, with chitin more than water miscible 100 orders or chitosan powder, in organic solvent, be dispersed into the 2%-20% suspension,, dry to finished product with applying, pad or infusion process being compounded on the fabric that contains water-soluble cellulose.
A kind of preparation method of water soluble polyose composite medical dressing, with water-soluble cellulose and water solublity etherificate, esterification chitin or chitosan in 1: 0.5-1: 2 ratio is mixed with solution, apply film forming subsequently on smooth surface, and vacuum drying is to finished product.
A kind of preparation method of water soluble polyose composite medical dressing, water-soluble plant polysaccharide and water soluble animal polysaccharide are ground into powder more than 300 orders, press 5-50: the mixed of 95-50, get mixture 10-60 part, seal, add propellant 90-40 part subsequently, make the powdery aerosol.
Beneficial effect of the present invention is: the compositely proportional of suitably controlling animal polysaccharide and vegetable polysaccharides, and grafting condition, can make the antibiotic based composite dressing for medical use of water-soluble natural, be used for wound and surgical hemostasis, transudate absorption, prevent adhesion, both are had complementary advantages, make hemostasis well, absorb based composite dressing for medical use fast, pliable and tough, comfortable, natural antibacterial, bacteriostasis rate is higher than 70%.
The specific embodiment
First specific embodiment of the present invention is got viscose rayon 5 grams that contain 15% chitin, adds 40% (W/W) NaOH40ml, room temperature reaction 2 hours; Add 70% (W/W) monoxone 15ml; 75 ℃ were reacted 6 hours, and were neutralized to 7 with acetic acid; Use 85% washing with alcohol, oven dry.
Second specific embodiment of the present invention, with 8% water-soluble carboxymethyl sodium cellulosate colloid, coated or be printed on 5 * 10cm by certain decorative pattern
2On the Sodium Tvlose gauze, cover 5 * 10cm again
2The carboxymethyl chitin non-woven fabrics, 110 ℃ of pressurization 5min get final product; Perhaps with 10% water-soluble chitosan colloid, coated (or by certain decorative pattern printing) is at 5 * 10cm
2On the Sodium Tvlose gauze, cover 5 * 10cm again
2Carboxymethyl chitin (chitosan) non-woven fabrics, 120 ℃ of pressurization 3-5min get final product.
The 3rd specific embodiment of the present invention with the above chitins of water solublity 200 orders (chitosan) powder, is configured to 20% suspension in 75% ethanol, pad this suspension with the sodium alginate fabric nonwoven cloth, and pick-up rate 80% is dried.
The 4th specific embodiment of the present invention, with Sodium Tvlose 5% aqueous solution and 5% carboxymethyl chitin sodium water solution, by 1: 1 mixed, lyophilization, can be made into spongy,
The 5th specific embodiment of the present invention with Sodium Tvlose and the carboxymethyl chitosan mixed by 1: 0.3, is ground into 400 order powder, gets 4 parts, injects the aerosol tank body, after the sealing, injects 6 parts of LPG, makes the powdery aerosol.
Claims (11)
1. water soluble polyose composite medical dressing, it is characterized in that: described medical dressing is with through having water miscible vegetable polysaccharides behind the overactivation and to have water miscible animal polysaccharide behind overactivation compound, or with water solublity, the natural antibacterial type based composite dressing for medical use of plant or the compound postactivated formation of animal polysaccharide material.
2. water soluble polyose composite medical dressing as claimed in claim 1 is characterized in that: described water-soluble plant polysaccharide comprises cellulose or regenerated cellulose or sodium alginate or the hyaluronic acid after the activated grafting; Described water soluble animal polysaccharide comprises the chitin after the activated grafting, or chitosan.
3. water soluble polyose composite medical dressing as claimed in claim 2 is characterized in that: described medical dressing is that water miscible vegetable polysaccharides and water soluble animal polysaccharide are compounded in the paster that forms on fabric or non-woven fabrics or the fiber.
4. water soluble polyose composite medical dressing as claimed in claim 2, it is characterized in that: described medical dressing is that water miscible vegetable polysaccharides and animal polysaccharide are mixed with mixed solution, be coated in the film that forms on glass or the stainless smooth surface, or the sponge that the mixed solution lyophilization is formed.
5. water soluble polyose composite medical dressing as claimed in claim 2 is characterized in that: described medical dressing is that water miscible vegetable polysaccharides and animal polysaccharide are ground into powder, adds the aerosol that propellant forms.
6. the preparation method of water soluble polyose composite medical dressing as claimed in claim 3, it is characterized in that: fabric or the non-woven fabrics or the fiber that will be compounded with water-insoluble vegetable polysaccharides cellulose and animal polysaccharide chitin or chitosan, put into the NaOH of 10%-25%, reaction is 1-3 hour under the room temperature, press material weight subsequently than 1.0: 1.1-2.0 adds organic acid, 20-75 ℃ was reacted 3-8 hour, then in organic solvent, be neutralized to pH value 5-8, wash and remove impurity at last, dry to finished product.
7. the preparation method of water soluble polyose composite medical dressing as claimed in claim 3, it is characterized in that: the fabric that will contain water-soluble cellulose is compounded in by water-soluble glue on the fabric that contains water-soluble chitosan, and 130 ℃ of following temperature pressings were shaped in 3-10 minute.
8. the preparation method of water soluble polyose composite medical dressing as claimed in claim 7, it is characterized in that: described water-soluble glue is to contain chitin or the chitosan of water solublity through esterification, etherificate; This water-soluble glue by spray, apply or with 40-80 order wire mark on the fabric that contains water-soluble cellulose or non-woven fabrics or fiber.
9. the preparation method of water soluble polyose composite medical dressing as claimed in claim 3, it is characterized in that: the chitin powder that water miscible 100 orders are above, in organic solvent, be dispersed into the 2%-20% suspension, with applying, pad or infusion process being compounded on the fabric that contains water-soluble cellulose, dry to finished product.
10. the preparation method of water soluble polyose composite medical dressing as claimed in claim 4, it is characterized in that: with water-soluble cellulose and water solublity etherificate, esterification chitin or chitosan in 1: 0.5-1: 2 ratio is mixed with solution, on smooth surface, apply film forming subsequently, and vacuum drying is to finished product.
11. the preparation method of water soluble polyose composite medical dressing as claimed in claim 5, it is characterized in that: water-soluble plant polysaccharide and water soluble animal polysaccharide are ground into powder more than 300 orders, press 5-50: the mixed of 95-50, get mixture 10-60 part, seal, add propellant 90-40 part subsequently, make the powdery aerosol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100009355A CN101332309B (en) | 2006-01-12 | 2006-01-12 | Water soluble polyose composite medical dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100009355A CN101332309B (en) | 2006-01-12 | 2006-01-12 | Water soluble polyose composite medical dressing and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101332309A true CN101332309A (en) | 2008-12-31 |
| CN101332309B CN101332309B (en) | 2012-11-14 |
Family
ID=40195357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006100009355A Active CN101332309B (en) | 2006-01-12 | 2006-01-12 | Water soluble polyose composite medical dressing and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101332309B (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101905034A (en) * | 2010-07-19 | 2010-12-08 | 武汉理工大学 | Method for preparing biological polysaccharide self-assembly modificatory chitosan antibacterial biological material |
| CN102335451A (en) * | 2011-09-15 | 2012-02-01 | 德州海利安生物科技股份有限公司 | Medical colloid dressing with functions for inhibiting bacteria and promoting heal and application thereof |
| CN103061109A (en) * | 2012-12-14 | 2013-04-24 | 青岛海蓝生物制品有限公司 | Method for modifying non-water-soluble chitosan fiber into water-soluble chitosan fiber |
| CN103656730A (en) * | 2013-12-10 | 2014-03-26 | 徐花 | Medical chitosan dressing |
| CN103705971A (en) * | 2013-12-19 | 2014-04-09 | 褚加冕 | Composite hyaluronic acid (HA) wound dressing |
| CN104324413A (en) * | 2014-11-10 | 2015-02-04 | 华玉叶 | Preparation method of hydrogel dressing |
| CN107233617A (en) * | 2017-06-05 | 2017-10-10 | 浙江工业大学 | A kind of wound dressing of liquid chitosan and its preparation and application |
| WO2019071587A1 (en) * | 2017-10-13 | 2019-04-18 | Gunze Limited | Biological tissue-reinforcing material kit and biological tissue-reinforcing material |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297957A (en) * | 1999-12-01 | 2001-06-06 | 武汉大学 | Preparation and use of intermingled film or fiber of carboxymethyl chitosan and alginic acid |
| CN1120198C (en) * | 2001-04-30 | 2003-09-03 | 武汉大学 | Chitin/cellulose intermingling material and its preparation and use |
| CN1332081C (en) * | 2005-04-27 | 2007-08-15 | 武汉大学 | Blended fiber of sodium alginate/water soluble chitin, preparation method and application thereof |
-
2006
- 2006-01-12 CN CN2006100009355A patent/CN101332309B/en active Active
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101905034A (en) * | 2010-07-19 | 2010-12-08 | 武汉理工大学 | Method for preparing biological polysaccharide self-assembly modificatory chitosan antibacterial biological material |
| CN101905034B (en) * | 2010-07-19 | 2013-06-12 | 武汉理工大学 | Method for preparing biological polysaccharide self-assembly modificatory chitosan antibacterial biological material |
| CN102335451A (en) * | 2011-09-15 | 2012-02-01 | 德州海利安生物科技股份有限公司 | Medical colloid dressing with functions for inhibiting bacteria and promoting heal and application thereof |
| CN103061109A (en) * | 2012-12-14 | 2013-04-24 | 青岛海蓝生物制品有限公司 | Method for modifying non-water-soluble chitosan fiber into water-soluble chitosan fiber |
| CN103061109B (en) * | 2012-12-14 | 2016-03-02 | 青岛海蓝生物制品有限公司 | Water-insoluble chitin fiber modification becomes the method for water soluble chitosan fiber |
| CN103656730A (en) * | 2013-12-10 | 2014-03-26 | 徐花 | Medical chitosan dressing |
| CN103705971A (en) * | 2013-12-19 | 2014-04-09 | 褚加冕 | Composite hyaluronic acid (HA) wound dressing |
| CN103705971B (en) * | 2013-12-19 | 2016-01-20 | 褚加冕 | A kind of composite transparent matter acid wound dressing |
| CN104324413A (en) * | 2014-11-10 | 2015-02-04 | 华玉叶 | Preparation method of hydrogel dressing |
| CN107233617A (en) * | 2017-06-05 | 2017-10-10 | 浙江工业大学 | A kind of wound dressing of liquid chitosan and its preparation and application |
| WO2019071587A1 (en) * | 2017-10-13 | 2019-04-18 | Gunze Limited | Biological tissue-reinforcing material kit and biological tissue-reinforcing material |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101332309B (en) | 2012-11-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101332309B (en) | Water soluble polyose composite medical dressing and preparation method thereof | |
| CN105641733A (en) | Preparation method for compound antibacterial haemostatic wound dressing | |
| US20070104769A1 (en) | Bioabsorbable hemostatic gauze | |
| CN101138648A (en) | Method of preparing antimicrobial hemostasis Chinese medicine-containing biological dressings | |
| WO2018214007A1 (en) | Antibacterial wound dressing and preparation method and application thereof | |
| CN103550817B (en) | A kind of Bacterial cellulose/shitosan composite sponge dressing and preparation method thereof | |
| JP2008532662A (en) | Method for producing antimicrobial wound dressing and use thereof | |
| CN101049515B (en) | Method for preparing medical dressing of non-woven fabrics by wet-process blending chitosan and silk fibrino | |
| CN101716362B (en) | Bactericidal disinfectant material containing chlorine dioxide, and application thereof | |
| CN107456321B (en) | A kind of nanometer silver antimicrobial sanitary napkin and its production method | |
| EP1951326A2 (en) | Bioabsorbable hemostatic gauze | |
| CN101721734A (en) | Medical calcium alginate antiseptic dressing and preparation method thereof | |
| CN104436279A (en) | Preparation method for medical biological antiseptic chitosan dressing | |
| CN202699681U (en) | Composite biological dressing of carboxymethyl chitosan and calcium alginate | |
| CN107296975A (en) | A kind of antibacterial anti hemorrhagic based composite dressing for medical use and preparation method thereof | |
| KR101562604B1 (en) | Manufacturing method of wound gauze and the wound gauze manufactured by the same | |
| CN104491915B (en) | One kind is postoperative to prevent being adhered medical dressing and preparation method thereof | |
| CN104383585B (en) | A kind of three-dimensional manometer composite adhesive bandage and preparation and application thereof | |
| CN105616074A (en) | Highly-antibacterial novel slight-soluble healthcare sanitary napkin capable of adsorbing heavy metal particles | |
| US11136720B2 (en) | Moisture-proof, fibrous substrate having adjustable moisture and wet strength, and method for production thereof | |
| CN206026745U (en) | Anti bacteria dressing of slowly -releasing | |
| CN101721733B (en) | Medical chitosan antiseptic dressing and preparation method thereof | |
| CN111265709A (en) | Pediatric wound protection film for preventing pneumovirus infection and preparation method thereof | |
| CN105860544B (en) | It is a kind of using stalk as the preparation method of the composite absorbent material of base material | |
| CN211705027U (en) | Chitosan dressing with super-strong absorbability |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: BEIJING TAIKE SIMAN TECHNOLOGICAL TECHNOLOGY CO., Free format text: FORMER OWNER: ZHANG MEI Effective date: 20140321 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100062 CHONGWEN, BEIJING TO: 101304 SHUNYI, BEIJING |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20140321 Address after: 101304 Beijing city Shunyi District Li Qiao Zhen Li Li Road Bridge No. 5 Patentee after: Beijing Taikesiman Technology Development Co. Ltd. Address before: 100062 Beijing city Chongwen District South East market in East No. 3 Building 1 No. 401 Patentee before: Zhang Mei |
|
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhang Mei Inventor after: Zhang Jinyu Inventor before: Zhang Mei |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHANG MEI TO: ZHANG MEI ZHANG JINYU |