CN103656730A - Medical chitosan dressing - Google Patents
Medical chitosan dressing Download PDFInfo
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- CN103656730A CN103656730A CN201310662619.4A CN201310662619A CN103656730A CN 103656730 A CN103656730 A CN 103656730A CN 201310662619 A CN201310662619 A CN 201310662619A CN 103656730 A CN103656730 A CN 103656730A
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- dressing
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- medical chitosan
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Abstract
The invention discloses a medical chitosan dressing, and a preparation method thereof. The medical chitosan dressing is characterized in comprising following raw materials, by weight, 25 to 40 parts of chitosan, 5 to 15 parts of alginate, 1 to 5 parts of an antibacterial agent, 2 to 8 parts of a calming anti-inflammatory agent, and 2 to 10 parts of a plasticizer. The medical chitosan dressing is suitable for medical hemostasis, antibiosis and antiphlogosis, and promoting of wound healing.
Description
Technical field
The present invention relates to a kind of medical dressing, be specifically related to a kind of medical chitosan dressing and preparation method thereof.
Background technology
Chitin, chitosan and derivant thereof have the effects such as hemostasis, pain relieving, inhibition growth of microorganism, and these healings for wound surface have positive meaning.The effect of the wound healing of chitin, chitosan and derivant is at present proved by numerous scholars' institute.
Find after deliberation, the mechanism that chitosan promotes wound healing mainly: (1) is accelerated PMN cell and is exuded to wound district; (2) accelerate to ooze out, to form silk fabric fibrin and to activate fibroblast, move to wound district; (3) stimulating expression of macrophage moves; (4) stimulate fibroblast proliferation and III type collagen fiber to produce.
At present the put into production bleeding-stopping dressing ubiquity haemostatic effect of clinical use of industry is undesirable, and the problem such as the laminating degree of skin is poor, therefore still await further improving and improve its haemostatic effect and with the stickiness of skin histology.
Summary of the invention
First object of the present invention is to provide a kind of medical chitosan dressing, comprises the raw material of following weight portion: 25 ~ 40 parts of chitosans, 5 ~ 15 parts of alginates, 1 ~ 5 part of antibacterial, 2 ~ 8 parts of calm antiinflammatory, 2 ~ 10 parts of plasticizers.
Above-mentioned alginate is potassium alginate, sodium alginate or calcium alginate.
Above-mentioned antibacterial is nanometer silver inorganic antiseptic, nano zine oxide or Ammonium biphosphate.
Above-mentioned calm antiinflammatory is ciprofloxacin, rifamycin or metronidazole.
Above-mentioned plasticizer is glycerol, sorbitol, ethylene glycol, mannose or Polyethylene Glycol.
Above-mentioned dressing is powdery or membranaceous.
Second object of the present invention is to provide a kind of preparation method of medical chitosan dressing, wherein, the preparation of above-mentioned powdery dressing is by following processing step: take in proportion chitosan, alginate, antibacterial and calm antiinflammatory, be placed in agitator and stir 10 ~ 20 min, mix homogeneously bottling.
The preparation of above-mentioned membranaceous dressing is by following processing step: take in proportion chitosan, alginate, antibacterial and calm antiinflammatory, be placed in reactor, add 1% ~ 1.5% acetic acid aqueous solution, be stirred to abundant dissolving; Add plasticizer, continue to stir and heated at constant temperature 15 ~ 30 min at 80 ~ 110 ℃; This mixed solution is poured on masking mould, struck off, after being dried fully, demoulding.
Products material of the present invention is easily buied, and preparation method is simple, and haemostatic effect is positive.
the specific embodiment:
Below in conjunction with concrete case study on implementation, the present invention is described in further detail:
Embodiment 1:
By chitosan 40 kg, potassium alginate 15 kg, nanometer silver inorganic antiseptic 5 kg, ciprofloxacin 8 kg, are placed in agitator and stir 10 ~ 20 min, mix homogeneously, bottling.
Embodiment 2:
Take in proportion chitosan 40 kg, potassium alginate 15 kg, nanometer silver inorganic antiseptic 5 kg, ciprofloxacin 8 kg, are placed in reactor, add 1% ~ 1.5% acetic acid aqueous solution, are stirred to abundant dissolving; Add analytical pure level ethylene glycol 10 kg, continue to stir and heated at constant temperature 15 ~ 30 min at 80 ~ 110 ℃; This mixed solution is poured on masking mould, struck off, after being dried fully, demoulding.
Embodiment 3:
By chitosan 30 kg, sodium alginate 12 kg, nano zine oxide 5 kg, metronidazole 8 kg, are placed in agitator and stir 10 ~ 20 min, mix homogeneously, bottling.
Embodiment 4:
Take in proportion chitosan 30 kg, sodium alginate 12 kg, nano zine oxide 5 kg, metronidazole 8 kg, are placed in reactor, add 1% ~ 1.5% acetic acid aqueous solution, are stirred to abundant dissolving; Adding purity is more than 98% mannose 8 kg, continues to stir and heated at constant temperature 15 ~ 30 min at 80 ~ 110 ℃; This mixed solution is poured on masking mould, struck off, after being dried fully, demoulding.
Claims (8)
1. a medical chitosan dressing, is characterized in that, comprises the raw material of following weight portion: 25 ~ 40 parts of chitosans, 5 ~ 15 parts of alginates, 1 ~ 5 part of antibacterial, 2 ~ 8 parts of calm antiinflammatory, 2 ~ 10 parts of plasticizers.
2. medical chitosan dressing according to claim 1, is characterized in that, described alginate is potassium alginate, sodium alginate or calcium alginate.
3. medical chitosan dressing according to claim 2, is characterized in that, described antibacterial is nanometer silver inorganic antiseptic, nano zine oxide or Ammonium biphosphate.
4. medical chitosan dressing according to claim 3, is characterized in that, described calm antiinflammatory is ciprofloxacin, rifamycin or metronidazole.
5. medical chitosan dressing according to claim 4, is characterized in that, described plasticizer is glycerol, sorbitol, ethylene glycol, mannose or Polyethylene Glycol.
6. medical chitosan dressing according to claim 5, is characterized in that, described dressing is powdery or membranaceous.
7. a method of preparing medical chitosan dressing as claimed in claim 6, it is characterized in that, the preparation of described powdery dressing is by following processing step: take in proportion chitosan, alginate, antibacterial and calm antiinflammatory, be placed in agitator and stir 10 ~ 20 min, mix homogeneously bottling.
8. a method of preparing medical chitosan dressing as claimed in claim 6, it is characterized in that, the preparation of described membranaceous dressing is by following processing step: take in proportion chitosan, alginate, antibacterial and calm antiinflammatory, be placed in reactor, add 1% ~ 1.5% acetic acid aqueous solution, be stirred to abundant dissolving; Add plasticizer, continue to stir and heated at constant temperature 15 ~ 30 min at 80 ~ 110 ℃; This mixed solution is poured on masking mould, struck off, after being dried fully, demoulding.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310662619.4A CN103656730A (en) | 2013-12-10 | 2013-12-10 | Medical chitosan dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310662619.4A CN103656730A (en) | 2013-12-10 | 2013-12-10 | Medical chitosan dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103656730A true CN103656730A (en) | 2014-03-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310662619.4A Pending CN103656730A (en) | 2013-12-10 | 2013-12-10 | Medical chitosan dressing |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288827A (en) * | 2014-09-29 | 2015-01-21 | 张亚丽 | Haemostatic wound dressing |
| CN104307029A (en) * | 2014-09-29 | 2015-01-28 | 张亚丽 | Medical natural biological dressing |
| CN104368031A (en) * | 2014-11-07 | 2015-02-25 | 苏州维泰生物技术有限公司 | Medical antibacterial dressing and preparation method thereof |
| CN104984384A (en) * | 2015-07-27 | 2015-10-21 | 南阳市汇博生物技术有限公司 | Medical antibacterial dressing and preparation method thereof |
| CN106110383A (en) * | 2016-07-07 | 2016-11-16 | 浙江大学 | A kind of chitosan alginate dressing and freeze-drying process thereof |
| CN107137751A (en) * | 2017-05-20 | 2017-09-08 | 河南福切尔生物科技有限公司 | A kind of medical dressing of the globulin containing wheat germ |
| CN107802527A (en) * | 2017-12-12 | 2018-03-16 | 中国药科大学 | Muffin prepared using edible mushroom source combine dressing and preparation method thereof |
| CN108498844A (en) * | 2017-12-18 | 2018-09-07 | 张祖玲 | A kind of obstetrics and gynecology department quick hemostatic dressing and preparation method thereof |
| CN112295008A (en) * | 2020-11-10 | 2021-02-02 | 北京深核智能科技有限公司 | Bioactive dressing with anti-inflammatory and hemostatic functions |
| CN113425889A (en) * | 2021-06-25 | 2021-09-24 | 延安大学 | Antibacterial hemostatic sponge and preparation method and application thereof |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288827A (en) * | 2014-09-29 | 2015-01-21 | 张亚丽 | Haemostatic wound dressing |
| CN104307029A (en) * | 2014-09-29 | 2015-01-28 | 张亚丽 | Medical natural biological dressing |
| CN104368031A (en) * | 2014-11-07 | 2015-02-25 | 苏州维泰生物技术有限公司 | Medical antibacterial dressing and preparation method thereof |
| CN104368031B (en) * | 2014-11-07 | 2017-05-10 | 马明 | Medical antibacterial dressing and preparation method thereof |
| CN104984384A (en) * | 2015-07-27 | 2015-10-21 | 南阳市汇博生物技术有限公司 | Medical antibacterial dressing and preparation method thereof |
| CN106110383A (en) * | 2016-07-07 | 2016-11-16 | 浙江大学 | A kind of chitosan alginate dressing and freeze-drying process thereof |
| CN107137751A (en) * | 2017-05-20 | 2017-09-08 | 河南福切尔生物科技有限公司 | A kind of medical dressing of the globulin containing wheat germ |
| CN107802527A (en) * | 2017-12-12 | 2018-03-16 | 中国药科大学 | Muffin prepared using edible mushroom source combine dressing and preparation method thereof |
| CN108498844A (en) * | 2017-12-18 | 2018-09-07 | 张祖玲 | A kind of obstetrics and gynecology department quick hemostatic dressing and preparation method thereof |
| CN112295008A (en) * | 2020-11-10 | 2021-02-02 | 北京深核智能科技有限公司 | Bioactive dressing with anti-inflammatory and hemostatic functions |
| CN112295008B (en) * | 2020-11-10 | 2021-08-10 | 广州图微科创生物科技有限公司 | Bioactive dressing with anti-inflammatory and hemostatic functions |
| CN113425889A (en) * | 2021-06-25 | 2021-09-24 | 延安大学 | Antibacterial hemostatic sponge and preparation method and application thereof |
| CN113425889B (en) * | 2021-06-25 | 2023-01-24 | 延安大学 | Antibacterial hemostatic sponge and preparation method and application thereof |
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Application publication date: 20140326 |