CN102258804A - Liquid bandage plaster and preparation method thereof - Google Patents
Liquid bandage plaster and preparation method thereof Download PDFInfo
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- CN102258804A CN102258804A CN2011102009721A CN201110200972A CN102258804A CN 102258804 A CN102258804 A CN 102258804A CN 2011102009721 A CN2011102009721 A CN 2011102009721A CN 201110200972 A CN201110200972 A CN 201110200972A CN 102258804 A CN102258804 A CN 102258804A
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- callicarpa nudiflora
- glycerol
- laurocapram
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Abstract
The invention discloses a liquid bandage plaster and a preparation method thereof. Raw materials of the liquid bandage plaster comprise polyvinyl alcohol, dioctyl phthalate, glycerol, laurocapram, chitosan and callicarpa nudiflora; and the preparation method comprises the following steps of: dissolving the polyvinyl alcohol and ethanol at the temperature of 50 DEG C by stirring; adding the laurocapram, the glycerol and the dioctyl phthalate to prepare membrane solution; and adding the callicarpa nudiflora into the prepared membrane solution, and mixing to be uniform. The liquid bandage plaster disclosed by the invention has the advantages of convenience in application, the effects of hemostasis, bacteriostasis, antiphlogosis and the like, good water-resisting property and good air permeability, no anaphylactic reaction and drug resistance and no restriction by size and shape of a wound.
Description
Technical field
The present invention relates to a kind of preparation method of liquid bandage, is a kind of medical dressing, belongs to field of medical technology.
Background technology
The product such as the various bandage that are used for the traumatic wounds nursing at present in the medical field, though have advantages such as inexpensive, easy to use, but in use also have some defectives: the used adhesive plaster breathability of traditional bandage is poor, body local normocrinic steam of institute and perspiration can not penetrate this layer adhesive plaster, so local skin is produced action of soaking, and it is wrinkled to be embodied in local skin; Be fixed on wound by tack coat, wound and extraneous poor sealing so just make dust or water infiltrate wound easily, make wound infection and cicatrix excessive; Various existing bandages all have certain size, are inconvenient to use for some specific wound site, and at present the medicine that adds in the bandage is only brought into play antibacterial, antiinflammation and drug resistance is often taken place.The research of pair liquid bandage is also arranged at present, and as ZL200410031161.3, but the product of determined curative effect seldom.And Callicarpa nudiflora in clinical use for many years, determined curative effect, diseases such as that dosage forms such as existing on the market Callicarpa nudiflora sheet, Callicarpa nudiflora suppository are used for the treatment of is hemorrhage, inflammation.Callicarpa nudiflora extract or effective ingredient are added in the dressing and can promote wound healing by antiinflammatory, hemostasis, analgesia, multi-efficiency such as antibacterial, also without any side effects.
Summary of the invention
The present invention seeks to problem at defective that exists in the prior art and existence, and provide a kind of liquid bandage, its easy to use, good permeability, promote wound healing by antiinflammatory, hemostasis, analgesia, multi-efficiency such as antibacterial, and without any side effects, can be used for the wound of any position, any size on the health.
The raw material of liquid bandage proposed by the invention is formed and proportioning is:
Polyvinyl alcohol 30-80 part dioctyl phthalate 0.5-10 part
Laurocapram 1-5 part glycerol 0.5-10 part
95% ethanol 100-200 part Callicarpa nudiflora 20-70 part,
Wherein, solid constituent with the corresponding relation of liquid components is: solid part unit is that the corresponding liquid part unit of g is ml, or solid part unit is that liquid part unit of Kg correspondence is L.
This prescription can be:
5 parts of 50 parts of dioctyl phthalates of polyvinyl alcohol
5 parts of 2 parts of glycerol of laurocapram
45 parts of 95% ethanol 100-200 part Callicarpa nudiflora,
Its preparation method is:
1), polyvinyl alcohol, ethanol are heated while stirring, after material to be filmed dissolves fully, add laurocapram, dioctyl phthalate and glycerol in 50-60 ℃ of water bath with thermostatic control, mix and stir Zhi De Mo liquid, mixing speed is 500-1000rpm;
2), Bian Jiao Ban Mo liquid, the limit promptly gets product to the effective site or the composition that wherein add the former powder of Callicarpa nudiflora or extract or extraction behind the mix homogeneously, mixing speed is 500-1000rpm.
Each raw material role is as follows in the above-mentioned bandage:
Polyvinyl alcohol is good film forming matter, has fine hygroscopicity, water solublity and pliability;
Dioctyl phthalate is the plasticizer of using always, makes film have good flexibility.Good emollescence is arranged, and stability and water proofing property are all better;
But the glycerol skin care prevents the skin be full of cracks.Clarification, thick liquid, odorless, water-soluble, pure, in air, easily absorb moisture, wound is preserved moisture better.
Laurocapram is typical case's representative of transdermal enhancer, promotes that osmosis is strong, and valid density is low, stable in properties, and toxicity is low, has no side effect, and can be widely used in transdermal drug delivery system.
Effects such as that Callicarpa nudiflora has is antibacterial, antiinflammatory, hemostasis, analgesia, convergence, and without any side effects.
The present invention forms the translucent film of one deck in conjunction with the advantage of traditional bandage and novel bandage dressing, adds Chinese medicine ingredients in the film, can play effects such as convergence, analgesia to wound.
Liquid bandage provided by the present invention has following characteristics:
1, has hemostasis, analgesia, convergence, antibacterial, promote effects such as wound healing;
2, good seal performance can prevent that antibacterial and foreign body from immersing wound, reduces and infects, and breathable waterproof is good simultaneously;
3, be not subjected to the restriction at wound size, shape, position, place, film forming has certain elasticity, thereby applies the position activity freely;
4, do not produce allergy and drug resistance, safe;
5, nonirritant;
6, carry, easy to use.
The specific embodiment
The specific embodiment of the invention is further specified the present invention, the invention is not restricted to following examples, and is any based on the variation of the equivalence on the technical solution of the present invention basis, all belongs within the protection domain of the present invention.
Embodiment 1:
Liquid bandage provided by the invention is semimobile paste when not contacting with air, and its raw material is formed and proportioning is: (weight portion)
10 parts of 80 parts of dioctyl phthalates of polyvinyl alcohol
10 parts of 5 parts of glycerol of laurocapram
70 parts of 200 parts of Callicarpa nudiflora of 95% ethanol,
Its preparation method is:
(1) 80 parts of polyvinyl alcohol, ethanol are heated while stirring in 50-60 ℃ of water bath with thermostatic control for 200 parts, after material to be filmed dissolves fully, add 10 parts of 5 parts of laurocaprams, 10 parts of dioctyl phthalates and glycerol, mix and stir Zhi De Mo liquid, mixing speed is 1000rpm;
(2) Callicarpa nudiflora extracts: get Callicarpa nudiflora, crushed after being dried becomes the Callicarpa nudiflora coarse powder, with the purified water extraction of 8 times of amounts 2 times, and merge extractive liquid,, filter, be condensed into thick paste, add 95% ethanol of 4 times of amounts, fully stir, the washing after-filtration, discard ethanol mother solution (recovery ethanol), the vacuum drying precipitate, it is standby to cross 80 mesh sieves after pulverizing;
(3) Bian Jiao Ban Mo liquid, the limit promptly gets product to 70 parts of the effective site that wherein adds the former powder of Callicarpa nudiflora or extract or extraction or compositions behind the mix homogeneously, and mixing speed is 1000rpm.Promptly get this liquid bandage.
This product is carried out skin irritation test and effect evaluation:
The skin irritation test
(1) zoopery
Observe the skin irritation of this product to Cavia porcellus.Method: this product is made single and repeatedly intact skin and injured skin irritation test with every square centimeter of skin 0.1g, 0.5g, 1g respectively to Cavia porcellus respectively, according to the form below 1 skin irritation reaction standards of grading are calculated integral mean value after being coated with this product, and are tried position histopathology of skin and check.
Table 1 skin irritation reaction scoring
Dermoreaction | Integration |
? Erythema and eschar form | ? |
No erythema | 0 |
Slight erythema (reluctantly as seen) | 1 |
Obvious erythema | 2 |
Moderate ~ severe erythema | 3 |
Serious erythema (aubergine) to slight eschar forms | 4 |
? Edema forms | ? |
No edema | 0 |
Slight edema (reluctantly as seen) | 1 |
Mild edema (the cutaneous protuberance profile is clear) | 2 |
Intermediate edema (the about 1mm of cutaneous protuberance) | 3 |
Severe edema's (cutaneous protuberance surpasses 1mm, expanded range) | 4 |
Top | 8 |
Result: this product high and low dose group single or multiple contact Cavia porcellus, its histopathology of skin checks with the blank group does not have significant difference, skin irritation reaction scoring is zero, shows this product in a short time to the Cavia porcellus nonirritant, and it is safe being used for part or whole skin.
(2) human experimentation
This product is applied on 30 volunteer's the back of the hand, is being tried back 12h, 1d, 2d, 4d, 8d respectively,, stop trying to observe behind the 8d, skin irritation reaction scoring is zero, shows this product nonirritant.
2, this product effect experiment:
Get 10 of rabbit, each Cavia porcellus is cut the wounds (0.2cm is dark, 0.8cm is long or 0.3 cm is dark, 1cm grow) of three equal sizes at RAT, is numbered a, b, c.The a wound is coated with this product, and the b wound sticks Bandaid, and the c wound is left intact, normal healing.Found that a wound heals at first, on average shift to an earlier date 20 hours than the b wound, cicatrix is shallow than the b wound, and the c wound has stream yellow fluid, inflammation phenomenon.
Embodiment 2:
Liquid bandage provided by the invention is semimobile paste when not contacting with air, and its raw material is formed and proportioning is: (weight portion)
0.5 part of 30 parts of dioctyl phthalate of polyvinyl alcohol
0.5 part of 1 part of glycerol of laurocapram
20 parts of 100 parts of Callicarpa nudiflora of 95% ethanol,
Its preparation method, skin irritation result, effect are substantially the same manner as Example 1.
Embodiment 3:
Liquid bandage provided by the invention is semimobile paste when not contacting with air, and its raw material is formed and proportioning is: (weight portion)
5 parts of 50 parts of dioctyl phthalates of polyvinyl alcohol
5 parts of 2 parts of glycerol of laurocapram
45 parts of 150 parts of Callicarpa nudiflora of 95% ethanol,
Its preparation method, skin irritation result, effect are substantially the same manner as Example 1.
Claims (4)
1. a liquid bandage is semimobile paste when not contacting with air, and its raw material is formed and proportioning is: (weight portion)
Polyvinyl alcohol 30-80 part dioctyl phthalate 0.5-10 part
Laurocapram 1-5 part glycerol 0.5-10 part
95% ethanol 100-200 part Callicarpa nudiflora 20-70 part,
Wherein, solid constituent with the corresponding relation of liquid components is: solid part unit is that the corresponding liquid part unit of g is ml, or solid part unit is that liquid part unit of Kg correspondence is L.
2. a kind of liquid bandage of claim 1 is characterized in that, raw material is formed and proportioning is:
5 parts of 50 parts of dioctyl phthalates of polyvinyl alcohol
5 parts of 2 parts of glycerol of laurocapram
45 parts of 95% ethanol 100-200 part Callicarpa nudiflora.
3. according to the described liquid bandage of claim 1-2, it is characterized in that: described Callicarpa nudiflora comprises the effective site or the composition of the former powder of Callicarpa nudiflora or extract or extraction, wherein extract comprises water, alcohol or diluted ketone extraction thing, and the effective site of extraction or composition comprise the mixture of one or more active component of flavone, tannin, phenols.
4. according to the preparation method of the described a kind of liquid bandage of claim 1-2, it is characterized in that step is:
1), polyvinyl alcohol, ethanol are heated while stirring, after material to be filmed dissolves fully, add laurocapram, dioctyl phthalate and glycerol in 50-60 ℃ of water bath with thermostatic control, mix and stir Zhi De Mo liquid, mixing speed is 500-1000rpm;
2), Bian Jiao Ban Mo liquid, the limit promptly gets product to the effective site or the composition that wherein add the former powder of Callicarpa nudiflora or extract or extraction behind the mix homogeneously, mixing speed is 500-1000rpm.
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CN2011102009721A CN102258804A (en) | 2011-07-19 | 2011-07-19 | Liquid bandage plaster and preparation method thereof |
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CN2011102009721A CN102258804A (en) | 2011-07-19 | 2011-07-19 | Liquid bandage plaster and preparation method thereof |
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103272260A (en) * | 2013-06-13 | 2013-09-04 | 海南医学院 | Chitosan composite medical dressing comprising callicarpa nudiflora extract and preparation method thereof |
CN104147646A (en) * | 2014-08-19 | 2014-11-19 | 张秀华 | Compound Callicarpa macrophylla Vahl sponge for surgical hemostasis, and preparation method thereof |
CN104548185A (en) * | 2015-02-10 | 2015-04-29 | 广州赛莱拉干细胞科技股份有限公司 | Liquid dressing and preparation method thereof |
CN105381502A (en) * | 2015-12-21 | 2016-03-09 | 杨雁 | Larva chrysomyiae liquid wound dressing and preparation method thereof |
CN106110382A (en) * | 2016-07-05 | 2016-11-16 | 李康 | A kind of preparation method of liquid bandage |
CN107951959A (en) * | 2017-12-22 | 2018-04-24 | 海南医学院 | A kind of callicarpa nudiflora plastics and preparation method thereof |
CN108815569A (en) * | 2018-06-20 | 2018-11-16 | 北京点域科技有限公司 | A kind of medical type wound repairs the preparation method of liquid |
CN114618012A (en) * | 2022-04-01 | 2022-06-14 | 上海医妃医药科技有限公司 | Liquid dressing with skin care effect |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101623394A (en) * | 2009-01-22 | 2010-01-13 | 九芝堂股份有限公司 | Nakedflower beautyberry extract as well as preparation method, preparation and application thereof |
CN101920042A (en) * | 2010-07-16 | 2010-12-22 | 四川理工学院 | Liquid bandage and preparation method |
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2011
- 2011-07-19 CN CN2011102009721A patent/CN102258804A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101623394A (en) * | 2009-01-22 | 2010-01-13 | 九芝堂股份有限公司 | Nakedflower beautyberry extract as well as preparation method, preparation and application thereof |
CN101920042A (en) * | 2010-07-16 | 2010-12-22 | 四川理工学院 | Liquid bandage and preparation method |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103272260A (en) * | 2013-06-13 | 2013-09-04 | 海南医学院 | Chitosan composite medical dressing comprising callicarpa nudiflora extract and preparation method thereof |
CN104147646A (en) * | 2014-08-19 | 2014-11-19 | 张秀华 | Compound Callicarpa macrophylla Vahl sponge for surgical hemostasis, and preparation method thereof |
CN104548185A (en) * | 2015-02-10 | 2015-04-29 | 广州赛莱拉干细胞科技股份有限公司 | Liquid dressing and preparation method thereof |
CN105381502A (en) * | 2015-12-21 | 2016-03-09 | 杨雁 | Larva chrysomyiae liquid wound dressing and preparation method thereof |
CN106110382A (en) * | 2016-07-05 | 2016-11-16 | 李康 | A kind of preparation method of liquid bandage |
CN107951959A (en) * | 2017-12-22 | 2018-04-24 | 海南医学院 | A kind of callicarpa nudiflora plastics and preparation method thereof |
CN107951959B (en) * | 2017-12-22 | 2021-01-26 | 海南医学院 | Callicarpa nudiflora film coating agent and preparation method thereof |
CN108815569A (en) * | 2018-06-20 | 2018-11-16 | 北京点域科技有限公司 | A kind of medical type wound repairs the preparation method of liquid |
CN114618012A (en) * | 2022-04-01 | 2022-06-14 | 上海医妃医药科技有限公司 | Liquid dressing with skin care effect |
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Address after: 410205 Changsha high tech Zone, Tongzi, west slope road, No. 339, No. Applicant after: Jiuzhitang Co., Ltd. Address before: 410008 Hunan province Changsha Kaifu District, Furong Road No. 129 Applicant before: Jiuzhitang Co., Ltd. |
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Application publication date: 20111130 |