CN103272260A - Chitosan composite medical dressing comprising callicarpa nudiflora extract and preparation method thereof - Google Patents
Chitosan composite medical dressing comprising callicarpa nudiflora extract and preparation method thereof Download PDFInfo
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- CN103272260A CN103272260A CN2013102306708A CN201310230670A CN103272260A CN 103272260 A CN103272260 A CN 103272260A CN 2013102306708 A CN2013102306708 A CN 2013102306708A CN 201310230670 A CN201310230670 A CN 201310230670A CN 103272260 A CN103272260 A CN 103272260A
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Abstract
The invention relates to a composite medical dressing, and belongs to the field of functional medical dressings. The medical dressing comprises a non-woven fabric and a chitosan coating comprising a callicarpa nudiflora extract, and the mass percent of the chitosan coating comprising the callicarpa nudiflora extract accounts for 20%-100% of the composite medical dressing. The preparation method comprises the steps as follows: water is added to callicarpa nudiflora, and the callicarpa nudiflora is extracted and subjected to alcohol precipitation, so that the callicarpa nudiflora extract is obtained; the chitosan is dissolved in a water solution containing acetic acid, the concentration of the chitosan is enabled to be 3%-5%, the callicarpa nudiflora extract accounting for 10%-40% of the mass of the chitosan is added and ground uniformly, so that a chitosan coating liquid of the callicarpa nudiflora extract is obtained; and under the hot air flow at the temperature of 60 DEG C-100 DEG C, the non-woven fabric is coated with the coating, and drying, cutting, sealing and packaging are performed, so that the chitosan composite medical dressing is obtained. The composite medical dressing is simple in preparation method and high in functionality, and has the effects of stopping bleeding, preventing inflammation and promoting wound healing.
Description
Technical field:
The invention belongs to functional medical dressing field, be specifically related to a kind of medical dressing with antibiotic, antiinflammatory, promotion wound healing.
Background technology:
Medical dressing is for various wounds, wound surface are covered, make it to avoid the influence of bacterial infection and other foeign elements, play protection wound, wound surface, promote the medical material of healing temporarily.Desirable medical dressing should have following function: 1. can keep the temperature of wound surface, form thereby accelerate epithelial tissue; 2. can absorb the wound surface exudate effectively; 3. have good permeability, and can effectively intercept antibacterial and harmful particle; 4. has excellent biological compatibility; 5. stable storing is easy to use.
The sorting technique of medical dressing is a lot, can classify respectively according to its raw material, structure composition, dosage form and occupation mode etc.Medical dressing substantially can be divided into four types of natural material class, synthetic class, complex class and organizational project classes by its preparation feedstock property.
Progressively develop into the wound dressing of the high-tech component content of today by traditional gauze, breakthrough variation has taken place in the kind of dressing.But clinical needs are also had higher requirement to dressing.
Loading active component dressing is to use comparatively mature technique at present, namely adds the active component that some helps wound healing by certain technology in dressing.In the active component that adds, chemobiotic easily produces drug resistance, acts on single.And the Chinese medicine extract aboundresources, effect more comprehensively, therefore have a extensive future, if any reporting that gelatin/Pseudobulbus Bletillae (Rhizoma Bletillae) glue drug-loaded biological dressing is timbering material with gelatin and Pseudobulbus Bletillae (Rhizoma Bletillae) glue exactly, Chinese medicine extract such as Radix Salviae Miltiorrhizae, Rhizoma Coptidis are compound to wherein, be prepared into by freeze-drying have hemostatic analgesia, the spongy porous Chinese medicine dressing of effect such as anti-inflammation and promotion wound healing.
It is one of active component that the present invention adopts Callicarpa nudiflora extract.Callicarpa nudiflora (Callicarpa nudiflora Hook.Et Arn.) is Verenaceae Callicarpa plant.Multitude's medicine name is mended valve, main product in Hainan, Guangdong and Guangxi.Its leaf mildly bitter flavor, puckery, property is flat; Antibacterial anti hemorrhagic is arranged, eliminating inflammation and expelling toxin, the function of dissipating blood stasis for subsidence of swelling.Be used for suppurative inflammation, acute infectious hepatitis, respiratory tract and digestive tract hemorrhage, thrombocytopenic purpura; Burn and traumatic hemorrhage are controlled in external, are one of Nationality in Hainan Province doctor medicinal herbs most in use.
The dressing carrier that the present invention adopts is chitosan; chitosan is the solable matter that obtains through acetylization reaction; because it has excellent biological compatibility, biodegradability and good film property, anticoagulant property, promotion wound healing function, enjoys scientific worker's concern.
As functional dressing layer, the present invention is adsorbed in Callicarpa nudiflora extract in the chitosan sponge, has improved that it is antibiotic, the effect of antiinflammatory and promotion wound healing.In order to bring into play the covering property of dressing better, prevent wound contamination in addition, the present invention is compound in the Callicarpa nudiflora chitosan sponge on the non-woven fabrics, forms double-deck dressing.
Summary of the invention:
The object of the present invention is to provide a kind of medical dressing with effects such as hemostatic analgesia, anti-inflammation and promotion wound healings.
The technical scheme that realizes the object of the invention is as follows:
The present invention relates to a kind of based composite dressing for medical use, it is characterized in that described medical dressing is made of non-woven fabrics and the chitosan coat that contains Callicarpa nudiflora extract, the mass percent that contains the chitosan coat of Callicarpa nudiflora extract accounts for 20%～100% of based composite dressing for medical use.Described Callicarpa nudiflora extract is with behind the Callicarpa nudiflora crude drug extracting in water, concentrates, and adding ethanol to the volumetric concentration ratio of ethanol is 60%, filters, and gets supernatant, reclaims ethanol to ethanol volumetric concentration ratio and is lower than 5%.
The advantage of this medical dressing is that preparation method is simple, and is functional strong, has the effect of hemostasis, antiinflammatory and promotion wound healing.
The invention still further relates to a kind of preparation method of based composite dressing for medical use of summary of the invention as described above, comprise the steps:
A. with behind the Callicarpa nudiflora crude drug extracting in water, concentrate, adding ethanol to the volumetric concentration ratio of ethanol is 60%, filters, and gets supernatant, reclaims ethanol to ethanol volumetric concentration ratio and is lower than 5%, gets Callicarpa nudiflora extract, measures the solid content of extract;
B. chitosan is dissolved in mass concentration ratio and is in 2%～5% the acetic acid aqueous solution, the concentration that makes chitosan is 3%～5%, 10%～40% the Callicarpa nudiflora extract that adds chitosan mass, preferred ratio is 25%～30%, grind evenly with even newborn machine, get the chitosan coat liquid of Callicarpa nudiflora extract;
C. non-woven fabrics is tiled, under 60 ℃～100 ℃ thermal currents, the chitosan coat liquid of Callicarpa nudiflora extract is sprayed on the non-woven fabrics, spraying rate is decided according to the coating rate of drying, with coating immediately drying be advisable, quantity for spray is that the mass percent that contains the chitosan coat of Callicarpa nudiflora extract accounts for 20%～100% of based composite dressing for medical use; Described non-woven fabrics is conventional medical adhesive-bonded fabric.
D. the non-woven fabrics that spraying is finished is by the specification cutting, and airtight package namely.
Among the step a, the extracting method of Callicarpa nudiflora crude drug is that the Callicarpa nudiflora medical material is added 10～12 times of water gagings, decoct and extract 3 times, each 1 hour, merge extractive liquid, was concentrated into every milliliter of extracting solution and is equivalent to the 2g raw medicinal herbs, adding 95% ethanol to the volumetric concentration ratio of ethanol is 60%, filter, get supernatant, decompression recycling ethanol to ethanol volumetric concentration ratio is lower than 5%, get Callicarpa nudiflora extract, measure the solid content of extract;
Among the step b, the Callicarpa nudiflora extract of adding accounts for 20%～40% of chitosan mass, and preferably 25%～30%.
Among the step c, dry air temperature is 80～100 ℃.
Beneficial effect:
That the chitosan that contains Callicarpa nudiflora extract has is antibiotic, the effect of antiinflammatory and promotion wound healing, yet this film strength is low excessively, if gain in strength thin film made the blocked up breathability that influences thin film again.
The chitosan that the present invention will contain Callicarpa nudiflora extract is sprayed on the conventional medical adhesive-bonded fabric, can utilize the intensity of non-woven fabrics stiffened shell polysaccharide thin film, has preferably breathability simultaneously again and prevents the outside contamination ability.
The material source of based composite dressing for medical use of the present invention is stable to be easy to get, and preparation process is simple, easy control of process conditions.
The specific embodiment
Below in conjunction with specific embodiment, further specify content of the present invention.These embodiment only are used for explanation and help and understand the present invention, limit the scope of the invention and be not used in.
Embodiment 1:
A. with Callicarpa nudiflora 2kg, after adding 10 times of water gagings respectively and extracting 3 times, each 1 hour, be evaporated to 2g raw medicinal herbs/mL, adding ethanol to the volumetric concentration ratio of ethanol is 60%, filter, with an amount of 60% washing with alcohol filtering residue, get supernatant, reclaim ethanol to ethanol volumetric concentration ratio and be lower than 5%, get Callicarpa nudiflora extract, measure the solid content of extract;
B. chitosan is dissolved in mass concentration ratio and is in 2% the acetic acid aqueous solution, the concentration that makes chitosan is 3%, adds 10% Callicarpa nudiflora extract of chitosan mass, grinds evenly with even newborn machine, gets the chitosan coat liquid of Callicarpa nudiflora extract;
C. non-woven fabrics is tiled, under 60 ℃ of thermal currents, the chitosan coat liquid of Callicarpa nudiflora extract is sprayed on the non-woven fabrics, spraying rate according to coating immediately drying be advisable, quantity for spray is that the mass percent that contains the chitosan coat of Callicarpa nudiflora extract accounts for 20% of based composite dressing for medical use.
D. the non-woven fabrics that spraying is finished is by the specification cutting, and airtight package namely gets the chitosan-based composite dressing for medical use that contains Callicarpa nudiflora extract.
Embodiment 2:
A. chitosan is dissolved in mass concentration ratio and is in 5% the acetic acid aqueous solution, the concentration that makes chitosan is 5%, 40% of chitosan mass Callicarpa nudiflora extract among the adding embodiment 1 grinds evenly with even newborn machine, gets the chitosan coat liquid of Callicarpa nudiflora extract;
B. non-woven fabrics is tiled, under 80 ℃ of thermal currents, the chitosan coat liquid of Callicarpa nudiflora extract is sprayed on the non-woven fabrics, spraying rate according to coating immediately drying be advisable, quantity for spray is that the mass percent that contains the chitosan coat of Callicarpa nudiflora extract accounts for 60% of based composite dressing for medical use.
C. the non-woven fabrics that spraying is finished is by the specification cutting, and airtight package namely gets the chitosan-based composite dressing for medical use that contains Callicarpa nudiflora extract.
Embodiment 3:
A. chitosan is dissolved in mass concentration ratio and is in 4% the acetic acid aqueous solution, the concentration that makes chitosan is 4%, 25% of chitosan mass Callicarpa nudiflora extract among the adding embodiment 1 grinds evenly with even newborn machine, gets the chitosan coat liquid of Callicarpa nudiflora extract;
B. non-woven fabrics is tiled, under 100 ℃ of thermal currents, the chitosan coat liquid of Callicarpa nudiflora extract is sprayed on the non-woven fabrics, spraying rate according to coating immediately drying be advisable, quantity for spray is that the mass percent that contains the chitosan coat of Callicarpa nudiflora extract accounts for 100% of based composite dressing for medical use.
C. the non-woven fabrics that spraying is finished is by the specification cutting, and airtight package namely gets the chitosan-based composite dressing for medical use that contains Callicarpa nudiflora extract.
Claims (6)
1. a based composite dressing for medical use is characterized in that described medical dressing is made of non-woven fabrics and the chitosan coat that contains Callicarpa nudiflora extract, and the mass percent that contains the chitosan coat of Callicarpa nudiflora extract accounts for 20%～100% of based composite dressing for medical use.
2. as right 1 described composite medical adjuvant, wherein Callicarpa nudiflora extract is with behind the Callicarpa nudiflora crude drug extracting in water, concentrates, and adding ethanol to the volumetric concentration ratio of ethanol is 60%, filters, and gets supernatant, reclaims ethanol to ethanol volumetric concentration ratio and is lower than 5%.
3. the preparation method as right 1 and 2 described based composite dressing for medical use comprises the steps:
A. with behind the Callicarpa nudiflora crude drug extracting in water, concentrate, adding ethanol to the volumetric concentration ratio of ethanol is 60%, filters, and gets supernatant, reclaims ethanol to ethanol volumetric concentration ratio and is lower than 5%, gets Callicarpa nudiflora extract, measures the solid content of extract;
B. chitosan is dissolved in mass concentration ratio and is in 2%～5% the acetic acid aqueous solution, the concentration that makes chitosan is 3%～5%, add 10%～40% Callicarpa nudiflora extract of chitosan mass, grind evenly with even newborn machine, get the chitosan coat liquid of Callicarpa nudiflora extract;
C. non-woven fabrics is tiled, under 60 ℃～100 ℃ thermal currents, the chitosan coat liquid of Callicarpa nudiflora extract is sprayed on the non-woven fabrics, spraying rate is decided according to the coating rate of drying, with coating immediately drying be advisable, quantity for spray is that the mass percent that contains the chitosan coat of Callicarpa nudiflora extract accounts for 20%～100% of based composite dressing for medical use;
D. the non-woven fabrics that spraying is finished is by the specification cutting, and airtight package namely.
4. the preparation method of based composite dressing for medical use as claimed in claim 3, among the step a, the extracting method of Callicarpa nudiflora crude drug is, the Callicarpa nudiflora medical material is added 10～12 times of water gagings, decoct and extract each 1 hour 3 times, merge extractive liquid,, be concentrated into every milliliter of extracting solution and be equivalent to the 2g raw medicinal herbs, adding 95% ethanol to the volumetric concentration ratio of ethanol is 60%, filters, get supernatant, decompression recycling ethanol to ethanol volumetric concentration ratio is lower than 5%, gets Callicarpa nudiflora extract, measures the solid content of extract.
5. the preparation method of based composite dressing for medical use as claimed in claim 3, among the step b, the Callicarpa nudiflora extract of adding accounts for 20%～40% of chitosan mass, and preferably 25%～30%.
6. the preparation method of based composite dressing for medical use as claimed in claim 3, among the step c, dry air temperature is 80～100 ℃.
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| CN107714299A (en) * | 2017-12-04 | 2018-02-23 | 广东泰宝医疗科技股份有限公司 | A kind of medical dressing is dispelled pain patch |
| CN107951959A (en) * | 2017-12-22 | 2018-04-24 | 海南医学院 | A kind of callicarpa nudiflora plastics and preparation method thereof |
| CN115400181A (en) * | 2022-08-01 | 2022-11-29 | 海南聚绅药业有限公司 | Preparation method of low-water-content callicarpa nudiflora capsule preparation |
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Application publication date: 20130904 |