CN103610766A - Cold-dispelling cold capsule - Google Patents

Cold-dispelling cold capsule Download PDF

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Publication number
CN103610766A
CN103610766A CN201310613165.1A CN201310613165A CN103610766A CN 103610766 A CN103610766 A CN 103610766A CN 201310613165 A CN201310613165 A CN 201310613165A CN 103610766 A CN103610766 A CN 103610766A
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China
Prior art keywords
cold
capsule
controlled
sieve
minute
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Pending
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CN201310613165.1A
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Chinese (zh)
Inventor
徐新云
卞学阁
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ANHUI LIANYI PHARMACEUTICAL Co Ltd
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ANHUI LIANYI PHARMACEUTICAL Co Ltd
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Priority to CN201310613165.1A priority Critical patent/CN103610766A/en
Publication of CN103610766A publication Critical patent/CN103610766A/en
Pending legal-status Critical Current

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Abstract

The invention discloses a cold-dispelling cold capsule which is characterized by being prepared from the raw materials in parts by weight: 850-950 parts of polygonum cuspidatum, 280-310 parts of pimpinella diversifolia, 180-210 parts of mysorethorn skins, starch, proper amount of 85% ethanol and proper amount of pure water. The capsule disclosed by the invention has the functions of mainly relieving exterior syndrome and dispelling cold and relieving cough and eliminating phlegm, and is used for treating patients with cold and patients with cold combined with bronchitis.

Description

A kind of cold expelling cold relief capsule
Technical field
The present invention relates generally to a kind of cold expelling cold relief capsule, belongs to field of medicaments.
Background technology
Flu, be divided into generally common cold and influenza, generally we said be all common cold.Common cold, motherland's medical science claims " cold ", is a kind of respiratory tract commonly encountered diseases being caused by multiple virus, wherein 30%-50% is that rhinovirus by certain serotype causes.Though common cold is mainly in early winter, in any season, as also occurred in spring, summer, the Causative virus of the flu of Various Seasonal is not just the same.Influenza is the Acute respiratory infectious disease being caused by influenza virus.Virus is present in patient's respiratory tract, when patient's cough, sneeze, through droplet infection, gives others.
Summary of the invention
The object of the invention is just to provide a kind of cold expelling cold relief capsule.
The present invention is achieved by the following technical solutions:
A cold expelling cold relief capsule, it is comprised of the raw material of following weight parts:
Rhizoma Polygoni Cuspidati 850-950, different leaf Pimpinella anisum Linn. 280-310, bark of Semen Caesalpiniae 180-210, starch, 85% appropriate amount of ethanol, purified water are appropriate.
A preparation method for cold expelling cold relief capsule, comprises the following steps:
(1) above-mentioned Rhizoma Polygoni Cuspidati, different leaf Pimpinella anisum Linn., bark of Semen Caesalpiniae are mixed, pulverize and sieve, extracting in water 3-4 time, filtration, merging filtrate, to be evaporated to relative density be 1.20(60 ℃) thick paste, dry, pulverize, cross No. 5 and sieve;
(2) above-mentioned starch is crossed to 100-120 mesh sieve;
(3) each raw material after above-mentioned processing is mixed to join in wet granulator to dry powder blend 10-12 minute;
(4) divide the ethanol that adds 85% for 2-5 time, running wet granulator, stirring at low speed 1-3 minute, makes soft material, then by 30 order nylon mesh, is placed on oscillating granulator, and soft material is made to wet grain;
(5) open the negative pressure system of boiling drier, granule is moved in ebullated dryer, the heating of transfer limit, limit, the baking temperature of wet grain is controlled between 35 ℃-40 ℃, is controlled at 7-10 minute drying time, and the moisture content of dry granule should be controlled between 4.0%-6.0%;
(6) total mixed, the capsule-filling of granulate.
Every dress 0.35g, oral, a 4-6 grain, 3 times on the one.
Advantage of the present invention is:
Capsule function of the present invention with cure mainly as the cold expelling that induces sweat, eliminating phlegm and stopping cough, is used for the treatment of Common Cold and flu merges bronchitis person.
The specific embodiment
Embodiment 1
A cold expelling cold relief capsule, it is comprised of the raw material of following weight parts (g):
Rhizoma Polygoni Cuspidati 900, different leaf Pimpinella anisum Linn. 300, bark of Semen Caesalpiniae 200, starch, 85% appropriate amount of ethanol, purified water are appropriate.
A preparation method for cold expelling cold relief capsule, comprises the following steps:
(1) above-mentioned Rhizoma Polygoni Cuspidati, different leaf Pimpinella anisum Linn., bark of Semen Caesalpiniae are mixed, pulverize and sieve, extracting in water 3 times, filtration, merging filtrate, to be evaporated to relative density be 1.20(60 ℃) thick paste, dry, pulverize, cross sieve No. 5;
(2) above-mentioned starch is crossed to 100 mesh sieves;
(3) each raw material after above-mentioned processing is mixed to join in wet granulator to dry powder blend 10 minutes;
(4) divide the ethanol that adds 85% for 3 times, running wet granulator, stirring at low speed 3 minutes, makes soft material, then by 30 order nylon mesh, is placed on oscillating granulator, and soft material is made to wet grain;
(5) open the negative pressure system of boiling drier, granule is moved in ebullated dryer, the heating of transfer limit, limit, the baking temperature of wet grain is controlled between 35 ℃-40 ℃, is controlled at 7-10 minute drying time, and the moisture content of dry granule should be controlled between 4.0%-6.0%;
(6) total mixed, the capsule-filling of granulate.
Differentiate:
(1) get this product content 2g, add ethyl acetate 50ml, reflux 1 hour, filters, filtrate evaporate to dryness, and residue adds ethanol 2ml to be made to dissolve, as need testing solution.Separately get gallic acid reference substance, add ethanol and make every 1ml containing the solution of 1mg, in contrast product solution.According to thin layer chromatography (appendix VI B of Chinese Pharmacopoeia version in 2010) test, draw each 1~2 μ l of above-mentioned two kinds of solution, put respectively in same and take the silica gel G F that sodium carboxymethyl cellulose is binding agent 254on lamellae, the chloroform-Ethyl formate-formic acid (5: 5: 1) of take is developing solvent, launches, and takes out, and dries, and puts under ultra-violet lamp (254nm) and inspects.In test sample chromatograph, with the corresponding position of reference substance chromatograph on, the fluorescence speckle of aobvious same color.
(2) get Rhizoma Polygoni Cuspidati control medicinal material 0.2g, add methanol 2ml, supersound process 10 minutes, standing, supernatant is medical material solution in contrast.Separately get emodin reference substance, add dehydrated alcohol and make every 1ml containing the solution of 1mg, in contrast product solution.According to thin layer chromatography (appendix VI B of Chinese Pharmacopoeia version in 2010), test, draw each 2~5 μ l of need testing solution, above-mentioned control medicinal material solution and reference substance solution under the item of [discriminating] (1), put respectively in same and take on the silica gel g thin-layer plate that sodium carboxymethyl cellulose is binding agent, the upper strata liquid of petroleum ether (30~60 ℃)-Ethyl formate-formic acid (15: 5: 1) of take is developing solvent, launch, take out, dry, put under ultra-violet lamp (365nm) and inspect.In test sample chromatograph, respectively with control medicinal material chromatograph and the corresponding position of reference substance chromatograph on, the fluorescence speckle of aobvious same color.
Check
Should meet every regulation relevant under capsule item (appendix I L of Chinese Pharmacopoeia version in 2010).
Assay
According to high performance liquid chromatography (appendix VI D of Chinese Pharmacopoeia version in 2010), measure.
Chromatographic condition and system suitability be take octadecylsilane chemically bonded silica as filler; Methanol-0.1% phosphoric acid (85: 15) of take is mobile phase, and detection wavelength is 290nm.Number of theoretical plate calculates and all should be not less than 2000 by emodin peak.
The preparation of reference substance solution: it is appropriate that precision takes emodin reference substance, adds methanol and makes every 1ml containing the solution of 50 μ g, shakes up, and obtains.
The content of 20 of this product is got in the preparation of need testing solution, porphyrize, gets about 0.25g, accurately weighed, add methanol 50ml, reflux, extract, 2 hours, filters, and methanol solution water-bath volatilizes, residue adds water 20ml, hydrochloric acid 3ml and chloroform 20ml hydrolysis 2 hours, minute gets chloroform layer, and chloroform washing is 3 times for acid liquid, each 10ml, merge chloroform liquid, water-bath volatilizes, and residue adds dissolve with methanol and is surely dissolved in 10ml measuring bottle, shake up, with microporous filter membrane (0.45 μ m), filter, get subsequent filtrate, obtain.
Algoscopy: precision is drawn reference substance solution and each 10 μ l of need testing solution respectively, and injection liquid chromatography, measures, and obtains.

Claims (2)

1. a cold expelling cold relief capsule, is characterized in that what it was comprised of the raw material of following weight parts:
Rhizoma Polygoni Cuspidati 850-950, different leaf Pimpinella anisum Linn. 280-310, bark of Semen Caesalpiniae 180-210, starch, 85% appropriate amount of ethanol, purified water are appropriate.
2. a preparation method for cold expelling cold relief capsule as claimed in claim 1, is characterized in that comprising the following steps:
(1) above-mentioned Rhizoma Polygoni Cuspidati, different leaf Pimpinella anisum Linn., bark of Semen Caesalpiniae are mixed, pulverize and sieve, extracting in water 3-4 time, filtration, merging filtrate, to be evaporated to relative density be 1.20(60 ℃) thick paste, dry, pulverize, cross No. 5 and sieve;
(2) above-mentioned starch is crossed to 100-120 mesh sieve;
(3) each raw material after above-mentioned processing is mixed to join in wet granulator to dry powder blend 10-12 minute;
(4) divide the ethanol that adds 85% for 2-5 time, running wet granulator, stirring at low speed 1-3 minute, makes soft material, then by 30 order nylon mesh, is placed on oscillating granulator, and soft material is made to wet grain;
(5) open the negative pressure system of boiling drier, granule is moved in ebullated dryer, the heating of transfer limit, limit, the baking temperature of wet grain is controlled between 35 ℃-40 ℃, is controlled at 7-10 minute drying time, and the moisture content of dry granule should be controlled between 4.0%-6.0%;
(6) total mixed, the capsule-filling of granulate.
CN201310613165.1A 2013-11-28 2013-11-28 Cold-dispelling cold capsule Pending CN103610766A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104523782A (en) * 2014-12-23 2015-04-22 钟桂英 Traditional Chinese medicine for preventing and treating cancers and preparation method of traditional Chinese medicine
CN106370767A (en) * 2016-08-29 2017-02-01 贵州信邦制药股份有限公司 Identification method of polygonum cuspidatum in arthralgia eliminating pill
CN106728018A (en) * 2016-12-27 2017-05-31 王麒瑞 A kind of Chinese medicine composition and its preparation and application for treating flu or bronchitis
CN109674761A (en) * 2019-02-26 2019-04-26 安徽联谊药业股份有限公司 A kind of cold dispelling cold Chinese medicine capsule and production technology

Citations (3)

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Publication number Priority date Publication date Assignee Title
CN1579531A (en) * 2004-05-17 2005-02-16 张红 Medicinal composition for treating anemopyretic cold and its preparation method
CN1589852A (en) * 2003-08-28 2005-03-09 昆明滇虹药业有限公司 External use nose drop agent for treating common cold and its preparation method
CN1600352A (en) * 2003-09-25 2005-03-30 杭州健源生物技术有限公司 Combination of Chinese traditional medicine for curing common cold and preparation method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1589852A (en) * 2003-08-28 2005-03-09 昆明滇虹药业有限公司 External use nose drop agent for treating common cold and its preparation method
CN1600352A (en) * 2003-09-25 2005-03-30 杭州健源生物技术有限公司 Combination of Chinese traditional medicine for curing common cold and preparation method
CN1579531A (en) * 2004-05-17 2005-02-16 张红 Medicinal composition for treating anemopyretic cold and its preparation method

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梁安鹏等: "《中成药》", 30 June 2008, article "散寒感冒片", pages: 3511 *
王芳薇: "中西医结合治疗流行性感冒的临床分析", 《临床和实验医学杂志》, vol. 06, no. 12, 30 December 2007 (2007-12-30) *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104523782A (en) * 2014-12-23 2015-04-22 钟桂英 Traditional Chinese medicine for preventing and treating cancers and preparation method of traditional Chinese medicine
CN106370767A (en) * 2016-08-29 2017-02-01 贵州信邦制药股份有限公司 Identification method of polygonum cuspidatum in arthralgia eliminating pill
CN106728018A (en) * 2016-12-27 2017-05-31 王麒瑞 A kind of Chinese medicine composition and its preparation and application for treating flu or bronchitis
CN109674761A (en) * 2019-02-26 2019-04-26 安徽联谊药业股份有限公司 A kind of cold dispelling cold Chinese medicine capsule and production technology

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Application publication date: 20140305