CN103610766A - Cold-dispelling cold capsule - Google Patents

Abstract

The invention discloses a cold-dispelling cold capsule which is characterized by being prepared from the raw materials in parts by weight: 850-950 parts of polygonum cuspidatum, 280-310 parts of pimpinella diversifolia, 180-210 parts of mysorethorn skins, starch, proper amount of 85% ethanol and proper amount of pure water. The capsule disclosed by the invention has the functions of mainly relieving exterior syndrome and dispelling cold and relieving cough and eliminating phlegm, and is used for treating patients with cold and patients with cold combined with bronchitis.

Description

A kind of cold expelling cold relief capsule

Technical field

The present invention relates generally to a kind of cold expelling cold relief capsule, belongs to field of medicaments.

Background technology

Flu, be divided into generally common cold and influenza, generally we said be all common cold.Common cold, motherland's medical science claims " cold ", is a kind of respiratory tract commonly encountered diseases being caused by multiple virus, wherein 30%-50% is that rhinovirus by certain serotype causes.Though common cold is mainly in early winter, in any season, as also occurred in spring, summer, the Causative virus of the flu of Various Seasonal is not just the same.Influenza is the Acute respiratory infectious disease being caused by influenza virus.Virus is present in patient's respiratory tract, when patient's cough, sneeze, through droplet infection, gives others.

Summary of the invention

The object of the invention is just to provide a kind of cold expelling cold relief capsule.

The present invention is achieved by the following technical solutions:

A cold expelling cold relief capsule, it is comprised of the raw material of following weight parts:

Rhizoma Polygoni Cuspidati 850-950, different leaf Pimpinella anisum Linn. 280-310, bark of Semen Caesalpiniae 180-210, starch, 85% appropriate amount of ethanol, purified water are appropriate.

A preparation method for cold expelling cold relief capsule, comprises the following steps:

(1) above-mentioned Rhizoma Polygoni Cuspidati, different leaf Pimpinella anisum Linn., bark of Semen Caesalpiniae are mixed, pulverize and sieve, extracting in water 3-4 time, filtration, merging filtrate, to be evaporated to relative density be 1.20(60 ℃) thick paste, dry, pulverize, cross No. 5 and sieve;

(2) above-mentioned starch is crossed to 100-120 mesh sieve;

(3) each raw material after above-mentioned processing is mixed to join in wet granulator to dry powder blend 10-12 minute;

(4) divide the ethanol that adds 85% for 2-5 time, running wet granulator, stirring at low speed 1-3 minute, makes soft material, then by 30 order nylon mesh, is placed on oscillating granulator, and soft material is made to wet grain;

(5) open the negative pressure system of boiling drier, granule is moved in ebullated dryer, the heating of transfer limit, limit, the baking temperature of wet grain is controlled between 35 ℃-40 ℃, is controlled at 7-10 minute drying time, and the moisture content of dry granule should be controlled between 4.0%-6.0%;

(6) total mixed, the capsule-filling of granulate.

Every dress 0.35g, oral, a 4-6 grain, 3 times on the one.

Advantage of the present invention is:

Capsule function of the present invention with cure mainly as the cold expelling that induces sweat, eliminating phlegm and stopping cough, is used for the treatment of Common Cold and flu merges bronchitis person.

The specific embodiment

Embodiment 1

A cold expelling cold relief capsule, it is comprised of the raw material of following weight parts (g):

Rhizoma Polygoni Cuspidati 900, different leaf Pimpinella anisum Linn. 300, bark of Semen Caesalpiniae 200, starch, 85% appropriate amount of ethanol, purified water are appropriate.

A preparation method for cold expelling cold relief capsule, comprises the following steps:

(1) above-mentioned Rhizoma Polygoni Cuspidati, different leaf Pimpinella anisum Linn., bark of Semen Caesalpiniae are mixed, pulverize and sieve, extracting in water 3 times, filtration, merging filtrate, to be evaporated to relative density be 1.20(60 ℃) thick paste, dry, pulverize, cross sieve No. 5;

(2) above-mentioned starch is crossed to 100 mesh sieves;

(3) each raw material after above-mentioned processing is mixed to join in wet granulator to dry powder blend 10 minutes;

(4) divide the ethanol that adds 85% for 3 times, running wet granulator, stirring at low speed 3 minutes, makes soft material, then by 30 order nylon mesh, is placed on oscillating granulator, and soft material is made to wet grain;

(5) open the negative pressure system of boiling drier, granule is moved in ebullated dryer, the heating of transfer limit, limit, the baking temperature of wet grain is controlled between 35 ℃-40 ℃, is controlled at 7-10 minute drying time, and the moisture content of dry granule should be controlled between 4.0%-6.0%;

(6) total mixed, the capsule-filling of granulate.

Differentiate:

(1) get this product content 2g, add ethyl acetate 50ml, reflux 1 hour, filters, filtrate evaporate to dryness, and residue adds ethanol 2ml to be made to dissolve, as need testing solution.Separately get gallic acid reference substance, add ethanol and make every 1ml containing the solution of 1mg, in contrast product solution.According to thin layer chromatography (appendix VI B of Chinese Pharmacopoeia version in 2010) test, draw each 1～2 μ l of above-mentioned two kinds of solution, put respectively in same and take the silica gel G F that sodium carboxymethyl cellulose is binding agent ₂₅₄on lamellae, the chloroform-Ethyl formate-formic acid (5: 5: 1) of take is developing solvent, launches, and takes out, and dries, and puts under ultra-violet lamp (254nm) and inspects.In test sample chromatograph, with the corresponding position of reference substance chromatograph on, the fluorescence speckle of aobvious same color.

(2) get Rhizoma Polygoni Cuspidati control medicinal material 0.2g, add methanol 2ml, supersound process 10 minutes, standing, supernatant is medical material solution in contrast.Separately get emodin reference substance, add dehydrated alcohol and make every 1ml containing the solution of 1mg, in contrast product solution.According to thin layer chromatography (appendix VI B of Chinese Pharmacopoeia version in 2010), test, draw each 2～5 μ l of need testing solution, above-mentioned control medicinal material solution and reference substance solution under the item of [discriminating] (1), put respectively in same and take on the silica gel g thin-layer plate that sodium carboxymethyl cellulose is binding agent, the upper strata liquid of petroleum ether (30～60 ℃)-Ethyl formate-formic acid (15: 5: 1) of take is developing solvent, launch, take out, dry, put under ultra-violet lamp (365nm) and inspect.In test sample chromatograph, respectively with control medicinal material chromatograph and the corresponding position of reference substance chromatograph on, the fluorescence speckle of aobvious same color.

Check

Should meet every regulation relevant under capsule item (appendix I L of Chinese Pharmacopoeia version in 2010).

Assay

According to high performance liquid chromatography (appendix VI D of Chinese Pharmacopoeia version in 2010), measure.

Chromatographic condition and system suitability be take octadecylsilane chemically bonded silica as filler; Methanol-0.1% phosphoric acid (85: 15) of take is mobile phase, and detection wavelength is 290nm.Number of theoretical plate calculates and all should be not less than 2000 by emodin peak.

The preparation of reference substance solution: it is appropriate that precision takes emodin reference substance, adds methanol and makes every 1ml containing the solution of 50 μ g, shakes up, and obtains.

The content of 20 of this product is got in the preparation of need testing solution, porphyrize, gets about 0.25g, accurately weighed, add methanol 50ml, reflux, extract, 2 hours, filters, and methanol solution water-bath volatilizes, residue adds water 20ml, hydrochloric acid 3ml and chloroform 20ml hydrolysis 2 hours, minute gets chloroform layer, and chloroform washing is 3 times for acid liquid, each 10ml, merge chloroform liquid, water-bath volatilizes, and residue adds dissolve with methanol and is surely dissolved in 10ml measuring bottle, shake up, with microporous filter membrane (0.45 μ m), filter, get subsequent filtrate, obtain.

Algoscopy: precision is drawn reference substance solution and each 10 μ l of need testing solution respectively, and injection liquid chromatography, measures, and obtains.

Claims (2)

1. a cold expelling cold relief capsule, is characterized in that what it was comprised of the raw material of following weight parts:

Rhizoma Polygoni Cuspidati 850-950, different leaf Pimpinella anisum Linn. 280-310, bark of Semen Caesalpiniae 180-210, starch, 85% appropriate amount of ethanol, purified water are appropriate.

2. a preparation method for cold expelling cold relief capsule as claimed in claim 1, is characterized in that comprising the following steps:

(1) above-mentioned Rhizoma Polygoni Cuspidati, different leaf Pimpinella anisum Linn., bark of Semen Caesalpiniae are mixed, pulverize and sieve, extracting in water 3-4 time, filtration, merging filtrate, to be evaporated to relative density be 1.20(60 ℃) thick paste, dry, pulverize, cross No. 5 and sieve;

(2) above-mentioned starch is crossed to 100-120 mesh sieve;

(3) each raw material after above-mentioned processing is mixed to join in wet granulator to dry powder blend 10-12 minute;

(4) divide the ethanol that adds 85% for 2-5 time, running wet granulator, stirring at low speed 1-3 minute, makes soft material, then by 30 order nylon mesh, is placed on oscillating granulator, and soft material is made to wet grain;

(5) open the negative pressure system of boiling drier, granule is moved in ebullated dryer, the heating of transfer limit, limit, the baking temperature of wet grain is controlled between 35 ℃-40 ℃, is controlled at 7-10 minute drying time, and the moisture content of dry granule should be controlled between 4.0%-6.0%;

(6) total mixed, the capsule-filling of granulate.