CN104523782A - Traditional Chinese medicine for preventing and treating cancers and preparation method of traditional Chinese medicine - Google Patents
Traditional Chinese medicine for preventing and treating cancers and preparation method of traditional Chinese medicine Download PDFInfo
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- CN104523782A CN104523782A CN201410806852.XA CN201410806852A CN104523782A CN 104523782 A CN104523782 A CN 104523782A CN 201410806852 A CN201410806852 A CN 201410806852A CN 104523782 A CN104523782 A CN 104523782A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
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Abstract
The invention discloses a traditional Chinese medicine for preventing and treating cancers and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine for preventing and treating cancer diseases is characterized by consisting of the following raw materials in parts by weight: 100 parts of pimpinella diversifolia. The preparation method comprises a step of preparing a pimpinella diversifolia fluid extract from the traditional Chinese medicinal pimpinella diversifolia by virtue of a traditional Chinese medicinal fluid extract preparing method. The traditional Chinese medicine disclosed by the invention, which is prepared from natural Chinese medicinal herb pimpinella diversifolia is safe to use, and the traditional Chinese medicine is free from remarkable toxic or side effects through the comprehensive treatment of advanced cancers by virtue of the Chinese medicinal herb. The traditional Chinese medicine can be used for resisting bacteria and viruses, and inhibiting cancers; and the traditional Chinese medicine has immune functions of eliminating cancerous toxin and enhancing body cancer resistance.
Description
Technical field
The present invention relates to a kind of Chinese medicine for anti-curing oncoma and method for making, especially a kind of Chinese medicine for anti-curing oncoma with different leaf Pimpinella anisum Linn. preparation and method for making.
Background technology
Three large therapies of existing doctor trained in Western medicine operation, radiotherapy, chemotherapy can make tumor mass reduction or the disappearance of Advanced cancers patient, but there is larger defect and side effect, because the sticky high solidifying cancerous cell continuation adhesion work bed deposition that makes of the height of blood is bred and continues through blood road, lymphatic channel and implantation metastasis.Cancerous cell, once extensively transfer to other position, just cannot make resection operation, causes the relapse rate of tumor patient very high.And radiotherapy chemotherapy is to immunologic function, the organs such as hemopoietic function and digestive system Liver and kidney cardiopulmonary have serious toxic and side effects; This is mainly manifested in leukocyte reduction, inappetence, alopecia etc., immunity reduction etc.So radiotherapy chemotherapy, the overall condition for the tumor patient of liability is not only improved, and impels it to be more degrading on the contrary; Because chemicotherapy is while killing off tumor cells, cannot tell the good from the bad, normal cell can be killed unavoidably.
Prior art does not apply the Chinese medicine of different leaf Pimpinella anisum Linn. preparation control tumor disease, if application number is the patent of invention of 201210147440.0---a kind of different leaf Pimpinella anisum Linn. health tea, this Invention Announce is a kind of has strengthening the spleen and nourishing the stomach, the different leaf Pimpinella anisum Linn. health tea of the comprehensive health-care function such as hepatoprotective is invigorated blood circulation, heart-nourishing brain-nourishing and production method thereof; With parts by weight, different leaf Pimpinella anisum Linn. health tea comprises different leaf Pimpinella anisum Linn. 40 ~ 60 parts, Fructus Citri Sarcodactylis 1 ~ 60 part, burnt Fructus Hordei Vulgaris 1 ~ 60 part, Folium Camelliae sinensis 1 ~ 60 part, Folium Stevlae Rebaudianae 1 ~ 60 part, and compositions makes bag packaging tea through operations such as chopping, drying, pulverizing, compatibility, packaging, sterilizings.This different leaf Pimpinella anisum Linn. health tea is not used for cancer-resisting.
Summary of the invention
In order to solve prior art problem, the invention provides a kind of Chinese medicine and method for making of preventing and treating tumor disease, there is suppression or killing tumor cell, adjustment tumor patient body's immunity, improve its suffer from the effect of tumor disease symptom and sign.
Technical scheme: a kind of Chinese medicine preventing and treating tumor disease, comprises the raw material of following weight portion: different leaf Pimpinella anisum Linn. 100.Method for making: different for above Chinese crude drug leaf Pimpinella anisum Linn. is made different leaf Pimpinella anisum Linn. fluid extract by Chinese medicine fluid extract method for making.
Tumor patient instructions of taking: an oral 10-15 milliliter, 3 times on the one 30 days is a course for the treatment of; Take 90 days continuously.
Experimentation: confirm that different leaf Pimpinella anisum Linn. Chinese medicine fluid extract has obvious tumor-inhibiting action to rat liver cancer (H22) animal liver cancer model; Different leaf Pimpinella anisum Linn. Chinese medicine fluid extract has the effect strengthening mouse cell immunity and humoral immune function, and to K562 and A549 cell cycle, there is retardation, apoptotic effect is promoted to K562 and HepG2 cell, in protein level and mRNA level in-site are to K562 cell, short apoptogene BAX all has rise effect, to the expression of K562 cell and HepG2 cell proliferation and telomerase gene, there is remarkable inhibitory action, show that different leaf Pimpinella anisum Linn. has obvious antitumor action thus.
Experimental technique
:different leaf Pimpinella anisum Linn. fluid extract makes different leaf Pimpinella anisum Linn. fluid extract with different leaf Pimpinella anisum Linn. by Chinese medicine fluid extract method for making.Set up rat liver cancer (H22) zoografting tumor model, random mice is divided into normal group, model group, positive group, medicine is little, in, heavy dose of group and administration respectively, after experiment terminates, carry out the indexs of correlation such as tumour inhibiting rate, thymus index, spleen index, tumor tissue pathology to detect, result: the tumor growth of different leaf Pimpinella anisum Linn. fluid extract to tumor-bearing mice has obvious inhibitory action, the tumour inhibiting rate of basic, normal, high dosage group is respectively 31.08%, 42.36% and 46.20%, presents good dose-effect relationship.Pathological observation shows, and model group growth of tumour cell is vigorous, and tumor cell necrosis in various degree then appears in each medication group, conclusion: different leaf Pimpinella anisum Linn. fluid extract has obvious tumor-inhibiting action to rat liver cancer (H22) animal liver cancer model.
Different leaf Pimpinella anisum Linn. is tested by " food safety evaluation on toxicology test " in " health food inspection and assessment technical specification " (2003 editions), result shows acute toxicity test its mouse oral LD50 > 20g/kg, true border is nontoxic, long_term toxcity result of study confirms: the rat feeding trial on the 30th of different leaf Pimpinella anisum Linn., have no experimental animal and occur poisoning symptom, gross anatomy and structure observation no abnormality seen pathological change.Rat body weight, food-intake, food utilization, hemogram, blood biochemistry are all had no significant effect.Different leaf Pimpinella anisum Linn. high dose group dosage that is female, buck is human body recommended dose (60mg/kg BW/d) 120 times.Confirm that Chinese herbal medicine different leaf Pimpinella anisum Linn. long-term taking is safety non-toxic.
Clinical verification, divide experimental group and matched group: after experimental group adopts different leaf Pimpinella anisum Linn. fluid extract of the present invention to treat three courses for the treatment of (90 days), compared with treating after three courses for the treatment of with matched group (employing chemotherapy and radiation), the total effective rate adopting the experimental group Advanced cancers treatment of different leaf Pimpinella anisum Linn. fluid extract treatment of the present invention is 94.2%, matched group is 65.8% to the total effective rate that Advanced cancers is treated, and the total effective rate for the treatment of group is apparently higher than matched group.
1, case selection: select case 240 example meeting Advanced cancers diagnostic criteria, patient is divided into two groups at random, treatment group 120 example, wherein male 66 examples (hepatocarcinoma 16 example, pulmonary carcinoma 14 example, gastric cancer 13 example, esophageal carcinoma 9 example, cerebroma 6 example, rectal cancer 3 example, malignant lymphoma 5 example), female 54 example (hepatocarcinoma 10 example, pulmonary carcinoma 10 example, gastric cancer 10 example, esophageal carcinoma 8 example, cerebroma 5 example, rectal cancer 6 example, malignant lymphoma 5 example); 22 ~ 78 years old age, 50.1 years old mean age; The course of disease 3 ~ 18 months, average 9.2 months.Matched group 120 example, wherein male 64 examples (hepatocarcinoma 11 example, pulmonary carcinoma 17 example, gastric cancer 10, rectal cancer 8 example, bladder cancer 6 example, esophageal carcinoma 6 example, cerebroma 3 example, malignant lymphoma 3 example), female 56 example (hepatocarcinoma 9 example, pulmonary carcinoma 10 example, gastric cancer 9 example, rectal cancer 5 example, esophageal carcinoma 6 example, cerebroma 3 example, breast carcinoma 4 example, cervical cancer 3 example, ovarian cancer 3 example, malignant lymphoma 4 example); 25 ~ 80 years old age, 51.3 years old mean age; The course of disease 3 ~ 18 months, average 8.9 months.Two groups of qualifications and record of service are basically identical, and there was no significant difference, has comparability.
2, treatment group patient takes different leaf Pimpinella anisum Linn. fluid extract of the present invention, an oral 10-15 milliliter of being grown up, and 3 times on the one 30 days is a course for the treatment of; Take 90 days continuously.Matched group adopts chemotherapy and radiation.
3, criterion: effective: tumor tumor body reduces more than 5%, and subjective symptoms is obviously improved, cardinal symptom disappears; Effective: tumor tumor body reduces 2 ~ 5%, and clinical symptoms is obviously improved; Improve: tumor tumor body maintains original size, clinical symptoms is improved; Invalid: tumor tumor body continuation growth and clinical symptoms are without improvement or increase the weight of.
4, result: take in treatment group of the present invention, effective: 63 examples, effective 30 examples, improve 20 examples, invalid 7 examples, total effective rate 94.2%; Effective 45 examples in matched group, effective 23 examples, improve 10 examples, invalid 42 examples, total effective rate 65.0%; The total effective rate for the treatment of group is apparently higher than matched group.
As optimization, the Chinese medicine formula that the present invention prevents and treats tumor disease also adds Medulla Junci 0.2-2 part, Radix Astragali 5-10 part, Radix Panacis Quinquefolii 5-10 part make Chinese medicine fluid extract again.
As optimization, the present invention prevents and treats the Chinese medicine method for making of tumor disease, it is characterized in that: can also make micropowder, capsule, tablet and other Chinese medicine preparation.
Different leaf Pimpinella anisum Linn. acrid in the mouth, hardship, micro-sweet, slightly warm in nature; Return lung; Stomach, Liver Channel.Function cures mainly: loose wind lung qi dispersing, regulating QI to relieve pain, removing food stagnancy spleen invigorating, promoting blood circulation to restore menstrual flow, removing dampness and detoxicating.Main flu, cough, pertussis, pulmonary tuberculosis, lung abscess, headache, headache, bud pain, crisp hypochondriac pain, peratodynia, abdominal distention and pain, koro cold type of pain, rheumatic arthritis, impairment caused by overstrain, bone labor, dyspepsia, food stagnation, infantile malnutrition, acute filthy disease, dysentery, jaundice, malaria, menoxenia, dysmenorrhea, amenorrhea, swelling of the breast, corneal nebula, pharyngeal swelling, mumps, traumatic injury, eczema, skin pruritus, snakeworm wound.
Medulla Junci, is slightly cold, sweet, light; GUIXIN, lung, small intestinal, urinary bladder channel.Effect: relieving stranguria by diuresis, clearing heart fire.
Radix Astragali sweet in the mouth, temperature, GUIXIN, lung, spleen, kidney channel; Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis, expelling pus and toxin by strengthening QI, promoting tissue regeneration and ulcer healing.Cure mainly impractical swollen, chronic nephritis, the carbuncle difficulty of cardiopalmus of breathing hard, asthenia, weak, spontaneous perspiration, night sweat, chronic diarrhea, proctoptosis, uterine prolapse, body to burst or burst and do not hold back for a long time.The Radix Astragali has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.Jishengshenqiwan albuminuria can be eliminated, strengthen myocardial contraction, regulate blood sugar content.The Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and can the process of delaying cell aging.Radix Astragali instant, can decoct soup, soft extracts, infusing drugs in wine, enter dish etc.
Radix Panacis Quinquefolii sweet in the mouth, micro-hardship, cool.GUIXIN, lung, kidney channel.Function cures mainly: boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.For the deficiency of vital energy the moon lose, interior-heat, cough with asthma expectorant blood, deficiency-heat be tired of tired, quench one's thirst, dryness of the mouth and throat.
Advantage of the present invention is: 1, select the different leaf Pimpinella anisum Linn. of natural Chinese medicinal herb to be raw material, use safety, utilize Chinese herbal medicine Comprehensive Treatment Advanced cancers, without obvious toxic-side effects; Experiment proves that different leaf Pimpinella anisum Linn. single medicinal material fluid extract has removing damp-heat removing toxic substances, regulating QI to relieve pain, removing food stagnancy spleen invigorating, promoting blood circulation to restore menstrual flow; Loose wind lung qi dispersing; Improve effect of immunologic function.
2, preferably square with the removing toxic substances of different leaf Pimpinella anisum Linn. removing damp-heat, regulating QI to relieve pain, removing food stagnancy spleen invigorating, promoting blood circulation to restore menstrual flow; Loose wind lung qi dispersing; Improve effect of immunologic function, compatibility Medulla Junci relieving stranguria by diuresis, clearing heart fire, Radix Astragali invigorating qi and benefiting blood, warming YANG to promote diuresis, the effects such as removing toxic substances of calming the nerves, and Radix Panacis Quinquefolii supplement vigour, benefit strengthening spleen and lung, supplementing QI for promoting the production of body fluid, calm the nerves nourish heart, brain-tonifying effect.
3, the present invention has anti-bacteria and anti-virus, cancer suppressing action; There is the immunologic function removed carcinous toxin, improve body against cancer.
Detailed description of the invention
embodiment1: a kind of Chinese medicine preventing and treating tumor disease, comprises the raw material of following weight portion: different leaf Pimpinella anisum Linn. 100.Method for making: different for above Chinese crude drug leaf Pimpinella anisum Linn. is made different leaf Pimpinella anisum Linn. fluid extract by Chinese medicine fluid extract method for making.
Instructions of taking: an oral 10-15 milliliter, 3 times on the one 30 days is a course for the treatment of; Take 90 days continuously.
embodiment2: a kind of Chinese medicine preventing and treating tumor disease, comprises the raw material of following weight portion: different leaf Pimpinella anisum Linn. 100 parts, Medulla Junci 0.5 part, the Radix Astragali 5 parts, Radix Panacis Quinquefolii 10 parts.Method for making: different for above Chinese crude drug leaf Pimpinella anisum Linn. is made different leaf Pimpinella anisum Linn. compound recipe fluid extract by Chinese medicine fluid extract method for making.
Instructions of taking: an oral 10-15 milliliter, 3 times on the one 30 days is a course for the treatment of; Take 90 days continuously.
A kind of Chinese medicine preventing and treating tumor disease of the present invention, except making Chinese medicine fluid extract, can also make micropowder, capsule, tablet and other Chinese medicine preparation.
Claims (4)
1. prevent and treat a Chinese medicine for tumor disease, it is characterized in that the raw material comprising following weight portion: different leaf Pimpinella anisum Linn. 100.
2. prevent and treat a Chinese medicine method for making for tumor disease, it is characterized in that: the different leaf Pimpinella anisum Linn. of 100 weight portions is made different leaf Pimpinella anisum Linn. fluid extract by Chinese medicine fluid extract method for making.
3. the Chinese medicine of control tumor disease according to claim 1, is characterized in that: the raw material also comprising following weight portion: Medulla Junci 0.2-2 part, Radix Astragali 5-10 part, Radix Panacis Quinquefolii 5-10 part.
4. the Chinese medicine method for making of control tumor disease according to claim 2, is characterized in that: can also make micropowder, capsule, tablet and other Chinese medicine preparation.
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| CN201410806852.XA CN104523782A (en) | 2014-12-23 | 2014-12-23 | Traditional Chinese medicine for preventing and treating cancers and preparation method of traditional Chinese medicine |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362952A (en) * | 2015-12-14 | 2016-03-02 | 赵金 | Traditional Chinese medicine for preventing and treating tumor and preparation method of traditional Chinese medicine |
| CN115252699A (en) * | 2022-09-09 | 2022-11-01 | 宁德师范学院 | Composition for treating ovarian cyst and preparation method thereof |
Citations (2)
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| CN103536642A (en) * | 2013-10-29 | 2014-01-29 | 钟桂英 | Traditional Chinese medicine matched with pimpinella diversifolia in use |
| CN103610766A (en) * | 2013-11-28 | 2014-03-05 | 安徽联谊药业股份有限公司 | Cold-dispelling cold capsule |
-
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- 2014-12-23 CN CN201410806852.XA patent/CN104523782A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536642A (en) * | 2013-10-29 | 2014-01-29 | 钟桂英 | Traditional Chinese medicine matched with pimpinella diversifolia in use |
| CN103610766A (en) * | 2013-11-28 | 2014-03-05 | 安徽联谊药业股份有限公司 | Cold-dispelling cold capsule |
Non-Patent Citations (1)
| Title |
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| 徐晓卫，等: "浙江产异叶茴芹叶挥发油化学成分研究", 《中国药业》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362952A (en) * | 2015-12-14 | 2016-03-02 | 赵金 | Traditional Chinese medicine for preventing and treating tumor and preparation method of traditional Chinese medicine |
| CN115252699A (en) * | 2022-09-09 | 2022-11-01 | 宁德师范学院 | Composition for treating ovarian cyst and preparation method thereof |
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