CN105381502A - Larva chrysomyiae liquid wound dressing and preparation method thereof - Google Patents
Larva chrysomyiae liquid wound dressing and preparation method thereof Download PDFInfo
- Publication number
- CN105381502A CN105381502A CN201510956117.1A CN201510956117A CN105381502A CN 105381502 A CN105381502 A CN 105381502A CN 201510956117 A CN201510956117 A CN 201510956117A CN 105381502 A CN105381502 A CN 105381502A
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- China
- Prior art keywords
- parts
- fab
- liquid
- chrysomyiae
- larva
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
Abstract
The invention discloses a larva chrysomyiae liquid wound dressing and a preparation method thereof. The larva chrysomyiae liquid wound dressing is prepared from 15-70 parts of traditional Chinese medicine larva chrysomyiae, 30-80 parts of a polyvinyl alcohol film forming material, 0.5-10 parts of a dibutyl phthalate plasticizer, 0.5-10 parts of glycerinum and 1-5 parts of laurocapram. The preparation method comprises the steps that after the polyvinyl alcohol and ethyl alcohol are stirred to be dissolved, the laurocapram, the glycerinum and the dibutyl phthalate are added, a film solution is prepared, larva chrysomyiae is added into the film solution, the materials are mixed to be uniform, and then the larva chrysomyiae liquid wound dressing is prepared. The larva chrysomyiae liquid wound dressing has the effects of fighting bacteria, eliminating inflammations, promoting wound healing and the like and has the advantages that the breathability and the water-resisting property are good, no anaphylactic reaction or drug resistance is generated, and the wound dressing is not limited by the size and the shape of the wound. The larva chrysomyiae liquid wound dressing and the preparation method thereof are good in application prospect.
Description
Technical field
A kind of Chrysomyiame gacephala (Fab.) liquid bandage that the present invention relates to and preparation method thereof, is a kind of medical dressing, belongs to field of medical technology.
Background technology
Skin is that human body covers the widest organ, daily life is unavoidable with skin trauma in work, common bandage can hemostasis by compression, protection wound surface, prevention infection, have again volume little, use the advantages such as simple, easy to carry, but the adhesive plaster poor air permeability that common bandage is used, the normocrinic steam of body local and perspiration can not penetrate this layer of adhesive plaster, easy breed bacteria, cause or increase the weight of to infect; Secondly water and antibacterial easily immerse wound from gap, adhesive plaster edge, cause wound infection; Moreover, the size that most of bandage is all fixed and size, and be not suitable for the wound of various shape and size.The medicine that current adhesive bandage adds only plays effect that is antibacterial, antiinflammatory, and often drug resistance occurs.
Chrysomyiame gacephala (Fab.) is the larva of Calliphoridae insecticide chrysomyia megacephala (big head golden fly) or its nearly edge insecticide.General Chrysomyiame gacephala (Fab.) worm alive collect after in flowing water repeatedly in rinsing to polypide dirt get rid of totally, be drying to obtain.Chrysomyiame gacephala (Fab.) is existing artificial cultivation now, is cheaply easy to get, can greatly saves production cost.Chrysomyiame gacephala (Fab.) is containing protein, fat, chitosan, the materials such as 18 seed amino acids, antibacterial peptide, have heat clearing away, disappear stagnant, effect such as anti-inflammation, promotion wound healing, be usually used in infantile malnutrition abdominal distention, chancre, wound etc., its antibacterial and anti-inflammation functions advantage compared with Western medicine is to have no drug resistance.
The at present bandage of oneself listing mainly Japan and the U.S., the advantages such as they have waterproof, breathe freely, but also there is the shortcomings such as expensive.
Summary of the invention
The present invention is directed to defect and problem that traditional bandage and the liquid bandage that gone on the market exist, prepare and a kind ofly there is anti-inflammation and promote wound healing and the liquid bandage had no side effect.It is easy to use, waterproof breathable is good, with low cost, preparation technology simple, may be used for the wound of any position on health, any size.
The raw material composition of liquid bandage proposed by the invention and proportioning are:
Chrysomyiame gacephala (Fab.) 10-70 part
Polyvinyl alcohol 30-80 part
Dibutyl phthalate 0.5-10 part
Laurocapram 1-5 part
Glycerol 0.5-10 part
95% ethanol 100-200 part
Wherein, solid constituent with the corresponding relation of liquid components is: solid part unit is liquid part unit that g is corresponding is ml, or
Solid part unit is liquid part unit that Kg is corresponding is L.
This formula can be:
Chrysomyiame gacephala (Fab.) 30 parts
Polyvinyl alcohol 60 parts
Dibutyl phthalate 8 parts
Laurocapram 2 parts
Glycerol 6 parts
95% ethanol 100-200 part
Its preparation method is:
1), by polyvinyl alcohol, ethanol heat while stirring in 50-60 DEG C of water bath with thermostatic control, after material to be filmed dissolves completely, add laurocapram, dioctyl phthalate and glycerol, mix and blend obtains film liquid, and mixing speed is 500-900rpm;
2), Bian Jiao Ban Mo liquid, limit adds the effective site of the former powder of Chrysomyiame gacephala (Fab.) or extract or extraction wherein, namely obtains product after mix homogeneously, and mixing speed is 500-900rpm.
In above-mentioned bandage, each raw material role is as follows:
Polyvinyl alcohol is excellent film forming matter, has fine hygroscopicity, water solublity and pliability;
Dioctyl phthalate is conventional plasticizer, makes film have good flexibility.Have good emollescence, stability and water proofing property are all better;
Glycerol can skin care, prevents cracked skin.Clarification, thick liquid, odorless, water-soluble, alcohol, easily absorbs moisture in air, better to wound moisturizing.
Laurocapram is the Typical Representative of transdermal enhancer, and promote that osmosis is strong, valid density is low, stable in properties, and toxicity is low, has no side effect, and can be widely used in transdermal drug delivery system.
Chrysomyiame gacephala (Fab.) has the effects such as antibacterial, antiinflammatory, promotion wound healing, and without any side effects.
The present invention, in conjunction with the advantage of traditional bandage and novel bandage dressing, forms the translucent film of one deck, adds Chinese medicine ingredients, can play the effects such as convergence, analgesia to wound in film.
Chrysomyiame gacephala (Fab.) liquid bandage provided by the present invention has following characteristics:
1, there is hemostasis, analgesia, convergence, antibacterial, promote the effects such as wound healing;
2, good seal performance, can prevent antibacterial and foreign body from immersing wound, reduce and infect, breathable waterproof is good simultaneously;
3, not by the restriction at wound size, shape, position, place, film forming has certain elasticity, thus coating position activity freely;
4, do not produce allergy and drug resistance, safety is high;
5, nonirritant;
6, carry, easy to use.
Detailed description of the invention
The specific embodiment of the invention is further illustrated the present invention, the invention is not restricted to following examples, any based on the equivalence change on technical solution of the present invention basis, all belongs within scope.
Embodiment 1:
It is semimobile paste that liquid wound provided by the invention is attached to when not contacting with air, and its raw material composition and proportioning are: (weight portion)
Chrysomyiame gacephala (Fab.) 30 parts
Polyvinyl alcohol 60 parts
Dibutyl phthalate 8 parts
Laurocapram 2 parts
Glycerol 6 parts
95% ethanol 200 parts
Its preparation method is:
(1) polyvinyl alcohol 60 parts, ethanol 200 parts are heated while stirring in 50-60 DEG C of water bath with thermostatic control, after material to be filmed dissolves completely, add laurocapram 2 parts, dioctyl phthalate 8 parts and glycerol 6 parts, mix and blend get Mo liquid, mixing speed is 900rpm;
(2) Chrysomyiame gacephala (Fab.) extracts: get Chrysomyiame gacephala (Fab.), crushed after being dried becomes Chrysomyiame gacephala (Fab.) coarse powder, and with the 70% EtOH Sonicate ripple assisted extraction 2 times of 6 times amount, merge extractive liquid, filtration, is condensed into thick paste, and it is for subsequent use to dry, pulverize rear mistake 80 mesh sieve;
(3) Bian Jiao Ban Mo liquid, limit adds the effective site 30 parts of the former powder of Chrysomyiame gacephala (Fab.) or extract or extraction wherein, namely obtains product after mix homogeneously, and mixing speed is 900rpm.Obtain this liquid bandage.
Irritation test and application effect appraisal are carried out to this product:
Irritation test
(1) zoopery
Observe the skin irritation of this product to Cavia porcellus.Method: this product makes single and repeatedly intact skin and injured skin irritation test with every square centimeter of skin 0.1g, 0.5g, 1g to Cavia porcellus respectively respectively, after being painted with this product, according to the form below 1 skin wound repair standards of grading calculate integral mean value, and do the inspection of recipient site histopathology of skin.
Table 1 skin wound repair is marked
Result: this product high and low dose group single or multiple contact Cavia porcellus, its histopathology of skin checks with blank group without significant difference, skin irritation reaction scoring is zero, and showing this product in a short time to Cavia porcellus nonirritant, is safe for local or whole skin.
(2) human experimentation
This product is applied on 30 volunteer's the back of the hand, respectively at tested rear 12h, 1d, 2d, 4d, 8d, observe after stopping examination 8d, skin irritation reaction scoring is zero, shows this product nonirritant.
2, this application effect of products experiment:
Get rabbit 10, each Cavia porcellus cuts the wound (0.2cm is dark, 0.8cm is long or 0.3cm is dark, 1cm long) of three equal sizes at RAT, is numbered a, b, c.A wound is coated with this product, Bandaid on b adhesive bandage, and c wound is left intact, normal healing.Found that a wound heals at first, comparatively b wound on average 20 hours in advance, cicatrix is shallow compared with b wound, and c wound has stream yellow fluid, inflammation phenomenon.
Embodiment 2:
It is semimobile paste that liquid wound provided by the invention is attached to when not contacting with air, and its raw material composition and proportioning are: (weight portion)
Chrysomyiame gacephala (Fab.) 25 parts
Polyvinyl alcohol 60 parts
Dibutyl phthalate 8 parts
Laurocapram 2 parts
Glycerol 6 parts
95% ethanol 200 parts
Its preparation method, skin irritation result, effect are substantially the same manner as Example 1.
Embodiment 3:
It is semimobile paste that liquid wound provided by the invention is attached to when not contacting with air, and its raw material composition and proportioning are: (weight portion)
Chrysomyiame gacephala (Fab.) 50 parts
Polyvinyl alcohol 70 parts
Dibutyl phthalate 15 parts
Laurocapram 5 parts
Glycerol 10 parts
95% ethanol 200 parts
Its preparation method, skin irritation result, effect are substantially the same manner as Example 1.
Claims (5)
1. a Chrysomyiame gacephala (Fab.) liquid bandage is semimobile paste when not contacting with air, and its raw material composition and proportioning are (weight portion)
Chrysomyiame gacephala (Fab.) 10-70 part
Polyvinyl alcohol 30-80 part
Dibutyl phthalate 0.5-10 part
Laurocapram 1-5 part
Glycerol 0.5-10 part
95% ethanol 100-200 part
Wherein the corresponding relation of solid constituent and liquid components is: solid part unit for gram, corresponding liquid part unit is milliliter, or solid part unit be kilogram, and corresponding liquid part unit is liter.
2. a kind of Chrysomyiame gacephala (Fab.) liquid bandage of claim 1, is characterized in that proportioning raw materials is:
Chrysomyiame gacephala (Fab.) 30 parts
Polyvinyl alcohol 60 parts
Dibutyl phthalate 8 parts
Laurocapram 2 parts
Glycerol 6 parts
95% ethanol 200 parts.
3. the liquid bandage according to claim 1,2, is characterized in that: it plays anti-inflammation, the material of wound healing is mainly Chrysomyiame gacephala (Fab.).
4. the liquid bandage according to claim 1,2, is characterized in that: described Chrysomyiame gacephala (Fab.) comprises the effective site of the former powder of Chrysomyiame gacephala (Fab.) or extract or extraction, and wherein extract comprises water, alcohol or ethyl acetate extract.
5. the preparation method of a kind of Chrysomyiame gacephala (Fab.) liquid bandage according to claim 1,2, it is characterized in that, step is:
1) heat while stirring in polyvinyl alcohol, ethanol and 50-60 DEG C water bath with thermostatic control, after material to be filmed dissolves completely, add dibutyl phthalate, glycerol, laurocapram, mix and blend obtains film liquid, and mixing speed is 500-900rpm;
2) limit agitated-film liquid, limit adds the effective site of the former powder of Chrysomyiame gacephala (Fab.) or extract or extraction wherein, namely obtains product after mix homogeneously, and mixing speed is 500-900rpm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510956117.1A CN105381502A (en) | 2015-12-21 | 2015-12-21 | Larva chrysomyiae liquid wound dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510956117.1A CN105381502A (en) | 2015-12-21 | 2015-12-21 | Larva chrysomyiae liquid wound dressing and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN105381502A true CN105381502A (en) | 2016-03-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510956117.1A Pending CN105381502A (en) | 2015-12-21 | 2015-12-21 | Larva chrysomyiae liquid wound dressing and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617455A (en) * | 2016-03-30 | 2016-06-01 | 吴美燕 | Preparation method of Chinese herbal woundplast ointment |
| CN105816908A (en) * | 2016-04-29 | 2016-08-03 | 哈尔滨乾佰纳生物药业有限公司 | Waterproof liquid wound protection film and preparation method thereof |
| CN107189860A (en) * | 2017-06-15 | 2017-09-22 | 广东药科大学 | The preparation method of Luo Xianzi essential oils and its application for removing free radical |
| CN107468904A (en) * | 2017-08-24 | 2017-12-15 | 浙江医药高等专科学校 | Liquid bandage and preparation method thereof |
| CN112057718A (en) * | 2020-08-24 | 2020-12-11 | 浙江隆泰医疗科技股份有限公司 | Barrier material for respiratory system |
| CN112691123A (en) * | 2020-10-28 | 2021-04-23 | 杭州益科堂生物科技有限公司 | Preparation method of maggot film coating agent and application of maggot film coating agent in healing of skin wound of diabetic rat |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258804A (en) * | 2011-07-19 | 2011-11-30 | 九芝堂股份有限公司 | Liquid bandage plaster and preparation method thereof |
| CN104174009A (en) * | 2014-08-20 | 2014-12-03 | 中国人民解放军第四军医大学 | Fly larva protein preparation and application thereof |
| CN105106372A (en) * | 2015-09-07 | 2015-12-02 | 陈红 | Traditional Chinese medicine liquid adhesive bandage for preventing and treating bedsore with bacterial infection |
-
2015
- 2015-12-21 CN CN201510956117.1A patent/CN105381502A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258804A (en) * | 2011-07-19 | 2011-11-30 | 九芝堂股份有限公司 | Liquid bandage plaster and preparation method thereof |
| CN104174009A (en) * | 2014-08-20 | 2014-12-03 | 中国人民解放军第四军医大学 | Fly larva protein preparation and application thereof |
| CN105106372A (en) * | 2015-09-07 | 2015-12-02 | 陈红 | Traditional Chinese medicine liquid adhesive bandage for preventing and treating bedsore with bacterial infection |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617455A (en) * | 2016-03-30 | 2016-06-01 | 吴美燕 | Preparation method of Chinese herbal woundplast ointment |
| CN105816908A (en) * | 2016-04-29 | 2016-08-03 | 哈尔滨乾佰纳生物药业有限公司 | Waterproof liquid wound protection film and preparation method thereof |
| CN107189860A (en) * | 2017-06-15 | 2017-09-22 | 广东药科大学 | The preparation method of Luo Xianzi essential oils and its application for removing free radical |
| CN107468904A (en) * | 2017-08-24 | 2017-12-15 | 浙江医药高等专科学校 | Liquid bandage and preparation method thereof |
| CN112057718A (en) * | 2020-08-24 | 2020-12-11 | 浙江隆泰医疗科技股份有限公司 | Barrier material for respiratory system |
| CN112691123A (en) * | 2020-10-28 | 2021-04-23 | 杭州益科堂生物科技有限公司 | Preparation method of maggot film coating agent and application of maggot film coating agent in healing of skin wound of diabetic rat |
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Application publication date: 20160309 |