CN111603425B - Multifunctional effervescent tablet of skin disinfection cleaning solution and preparation method thereof - Google Patents
Multifunctional effervescent tablet of skin disinfection cleaning solution and preparation method thereof Download PDFInfo
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- CN111603425B CN111603425B CN202010489001.2A CN202010489001A CN111603425B CN 111603425 B CN111603425 B CN 111603425B CN 202010489001 A CN202010489001 A CN 202010489001A CN 111603425 B CN111603425 B CN 111603425B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention provides a multifunctional skin disinfection cleaning solution effervescent tablet and a preparation method thereof, wherein the multifunctional skin disinfection cleaning solution effervescent tablet comprises the following raw materials in parts by weight: 5 to 10 percent of chlorite, 2 to 6 percent of halogen source, 3 to 8 percent of pyrrolidone iodine, 0.1 to 0.5 percent of dichlorobenzyl alcohol, 10 to 20 percent of acid source, 5 to 12 percent of alkali source and the balance of effervescent tablet auxiliary materials; the acid source is one or more selected from citric acid and malic acid; the alkali source is selected from one or more of sodium bicarbonate, sodium carbonate, potassium bicarbonate and calcium carbonate; the effervescent tablet adjuvant comprises surfactant, rhizoma Zingiberis recens extract, aloe extract, essential oil, stabilizer, catalyst and dry antiseptic. The multifunctional effervescent tablet of the skin disinfection cleaning solution has good disinfection effect, the disinfection rate even reaches 99.99%, and no stimulation, fully utilizes the efficacy of each raw material, has good disinfection effect and stability of the disinfection effect, also has the functions of moisturizing, anti-inflammation and analgesia, can diminish inflammation and relieve pain, and accelerates the healing of wounds and relieves pain.
Description
Technical Field
The invention relates to the technical field of skin cleaning products, in particular to a multifunctional effervescent tablet of skin disinfection cleaning solution and a preparation method thereof.
Background
The hand sanitizer is a common skin-care cleansing liquid mainly used for cleaning hands, and dirt and attached bacteria on the hands are removed by mechanical friction and the action of a surfactant in cooperation with running water. The purpose of washing hands is to remove stains, bacteria and the like on the hands, and in particular, in an extremely long period of epidemic prevention and control, the duty of washing hands is more important in public health epidemic prevention, so that the cleaning performance and the sterilization rate of the hand sanitizer are one of important indexes of the quality of the hand sanitizer. However, most of the professional hand disinfection and sterilization cleaning products in the market are no-clean disinfection hand washing gel or liquid soap mainly comprising alcohol, isopropanol and chlorhexidine acetate, the products have high alcohol content, are flammable and explosive, have higher danger and safety supervision and restriction requirements, can be degreased and dehydrated after being contacted with alcohol, reduce the elasticity and luster of skin, have strong peculiar smell and poor use feeling, and are not suitable for people with alcohol allergy and children to use for a long time. Meanwhile, the disinfection and sterilization hand sanitizer with the components is only suitable for hand disinfection and cleaning based on a plurality of problems, at present, only products aiming at environment disinfection such as disinfection tablets, disinfection powder and 84 disinfection liquid are available in the market, and skin cleaning products which can be selected by people in the aspects of families and epidemic prevention control and can be safely used for human body whole body disinfection and sterilization are not available. In addition, the liquid amount of the unit package of the hand sanitizer cleaning products is large, the transportation and storage cost is extremely high, and the quality guarantee period is short. The effervescent tablet is prepared by reacting organic acid with alkali type carbonate (hydrogen) salt to obtain an effervescent disintegrant, and the effervescent reaction can be immediately carried out after the effervescent tablet is placed in water to release substances in the effervescent tablet and generate a hand sanitizer at any time. However, how to produce the multifunctional skin disinfection and cleaning solution effervescent tablet which can meet the control requirements of household and public health epidemic prevention, does not contain alcohol, can be safely used for the whole body disinfection and cleaning of a human body not limited to hands, has good sterilization effect, does not hurt the skin, is nontoxic and non-irritant, can be applied to the wound surface washing of the body, and aims at the wound surface to diminish inflammation, relieve pain and promote healing is the technical difficulty of the improvement of the existing effervescent tablet.
Disclosure of Invention
The invention aims to provide the multifunctional effervescent tablet of the skin disinfection cleaning solution, which has good sterilization and disinfection effects, no skin injury, no irritation, certain moisturizing effect, certain anti-inflammatory and analgesic effects, capability of promoting healing and good effective stability, and can be used for washing wound surfaces.
In order to achieve the purpose, the invention provides a multifunctional skin disinfection cleaning solution effervescent tablet which comprises the following raw materials in parts by weight: 5 to 10 percent of chlorite, 2 to 6 percent of halogen source, 3 to 8 percent of pyrrolidone iodine, 0.1 to 0.3 percent of dichlorobenzyl alcohol, 10 to 20 percent of acid source, 5 to 12 percent of alkali source and the balance of effervescent tablet auxiliary materials; the acid source is one or more selected from citric acid, tartaric acid, fumaric acid, adipic acid and malic acid; the alkali source is selected from one or more of sodium bicarbonate, sodium carbonate, potassium bicarbonate and calcium carbonate.
Preferably, the effervescent tablet auxiliary materials comprise a surfactant, a ginger extract, an aloe extract, essential oil, a stabilizer, a catalyst and a dry preservative.
Further preferably, the effervescent tablet auxiliary materials comprise the following components in percentage by weight of the total amount of the effervescent tablets of the multifunctional skin disinfection cleaning solution: 10 to 20 percent of surfactant, 5 to 15 percent of ginger extract, 5 to 15 percent of aloe extract, 5 to 15 percent of essential oil, 6 to 15 percent of stabilizer, 0.1 to 1 percent of catalyst and 0.1 to 2 percent of desiccant.
Further preferably, the essential oil is selected from one or more of thymol thyme, caraway, sweet marjoram, savory, frankincense, red pine, black pepper, hemlock, clove, allspice, cajeput, citronella, lemon eucalyptus, lemon fine seed, ylang, peru balsam, jasmine, aromatic white pearl and yellow birch essential oil.
Further preferably, the stabilizer is sodium chloride, and the surfactant is one or more of sodium lauryl sulfate, sodium fatty acid methyl ester sulfate, sodium lauryl polyether sulfate and natural soap powder.
Further preferably, the feed comprises the following raw materials in parts by weight: chlorite 7%, halogen source 3.5%, pyrrolidone iodine 6%, dichlorobenzyl alcohol 0.25%, acid source 18%, alkali source 10%, and effervescent tablet supplementary material.
A preparation method of the multifunctional skin disinfection cleaning solution effervescent tablet is used for preparing the multifunctional skin disinfection cleaning solution effervescent tablet, and comprises the following steps:
1) Mixing the chlorite and the halogen source according to the formula amount, adding the drying agent according to the formula amount, and mixing to obtain a mixture A;
2) Dissolving the acid source, the alkali source, the effervescent tablet auxiliary material and dichlorobenzyl alcohol in the formula amount in 95% ethanol, uniformly dispersing to form a mixed solvent, drying the mixed solvent to form dry blocks, volatilizing to remove ethanol, cooling and rolling the blocks, grinding and sieving to form a mixture B;
3) And mixing the mixture A and the mixture B, adding the pyrrolidone iodine, uniformly mixing, and tabletting by using an upper rotary tabletting machine to obtain the multifunctional skin disinfection cleaning solution effervescent tablet.
The invention has the beneficial effects that: the invention compounds dichlorobenzyl alcohol with pyrrolidone iodine and chlorine dioxide for use, fully utilizes the sterilization effects of the dichlorobenzyl alcohol, the pyrrolidone iodine and the chlorine dioxide, achieves the effect of low-concentration high sterilization effect, improves the sterilization efficiency and the safety of the effervescent tablet, ensures that the effervescent tablet has the effect of high-efficiency sterilization and cleaning, does not have stimulation or waste of stuffing of raw materials, ensures that the effervescent liquid obtained after the dissolution of the effervescent tablet can play a quick and lasting sterilization effect on common gram-positive bacteria, gram-negative bacteria fungi and the like, has good sterilization and disinfection effects and good sterilization and disinfection effect stability, in addition, the ginger extract is added in the effervescent tablet, further promotes the bacteriostasis effect of the product, has the functions of sterilization and disinfection while the aloe extract is added, also has the functions of moisture preservation, inflammation resistance and pain resistance, relieves the problem of desquamation and dryness caused by a plurality of hand washing to a certain extent, and in addition, the essential oil with the effects of anesthesia, inflammation resistance and pain resistance is added, and can effectively slow down pain feeling brought to people caused by the impact of a wound surface, and relieve the pain.
Compared with hand sanitizer and hand washing gel, the multifunctional skin disinfection cleaning solution effervescent tablet has small volume, is in a solid state, is convenient to carry, is different from alcohol hand sanitizer, and can be carried by boarding (in a car); convenient use, wide application range and good use effect, and is suitable for medical treatment and daily life.
Detailed Description
The embodiments described below are only a part of the embodiments of the present invention, and not all of them. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a multifunctional effervescent tablet of skin disinfection cleaning solution, which comprises the following components: chlorite, halogen source, pyrrolidone iodine, dichlorobenzyl alcohol, acid source, alkali source and effervescent tablet auxiliary materials.
Wherein the mass percentages of the components are as follows: chlorite 5% -10%, can be but is not limited to 5%, 6%, 7%, 8%, 9%, or 10%; 2% -6% of a halogen source, which can be but is not limited to 2%, 3%, 4%, 5% or 6%; pyrrolidone iodine 3% -8%, can be but not limited to 3%, 5%, 7% or 8%; dichlorobenzyl alcohol 0.1% -0.3%, which may be but is not limited to 0.1%, 0.2%, or 0.3%; 10% -20% of an acid source, which may be but is not limited to 10%, 12%, 14%, 16%, 18%, or 20%; an alkali source 5% -12%, may be but is not limited to 5%, 7%, 9%, 11% or 12%.
The acid source is one or more selected from citric acid and malic acid; the alkali source is selected from one or more of sodium bicarbonate, sodium carbonate, potassium bicarbonate and calcium carbonate. The alkali source reacts with the acid source to generate carbon dioxide gas when being dissolved, so that a local effervescent effect is generated, the dissolved reactants are stirred around the effervescent tablet, the reaction power is improved, and the dissolving process of the effervescent tablet is accelerated.
The halogen source can be bleaching powder produced by a sodium method, the main component of the halogen source is calcium hypochlorite, the calcium hypochlorite is generated after water is melted, the calcium hypochlorite is used as an oxidant in the reaction, chlorite is oxidized to generate chlorine dioxide, and the chlorine dioxide is converted into chloride ions and calcium malate or calcium citrate is dissolved in water, so that the liquid is clear and transparent. Chlorine dioxide is a high-efficiency, nontoxic, rapid and broad-spectrum disinfectant, has strong oxidizability, is an internationally recognized fourth-generation disinfectant, and can effectively kill bacteria, fungi, viruses, spores and the like.
The pyrrolidone iodine is a prodrug preparation, is an amorphous compound formed by combining polyvinylpyrrolidone and iodine, contains 9-12% of effective iodine, has the characteristics of stable property, good water solubility, no irritation and volatility, mild and durable action, safe use and the like compared with iodine solution, is a high-efficiency, broad-spectrum and low-toxicity disinfectant and bactericide, and has the antibacterial mechanism that the PVP-I has surface activity and emulsification effect, so that the PVP-I penetrability is enhanced on one hand, the emulsification effect destroys cell walls, the bacterial cell membrane permeability barrier is destroyed, PVP-I enters cells in a large amount, and cell contents leak out to cause the death of microorganisms.
The dichlorobenzyl alcohol has a sterilization effect by causing the denaturation, precipitation or coagulation of pathogenic microorganism proteins, is a broad-spectrum antibacterial agent, has low toxicity, no teratogenesis and no sensitization, has no stimulation to skin and mucous membrane within a certain concentration, has high safety, and can efficiently kill gram-positive cocci, gram-negative bacilli and fungi represented by staphylococcus aureus, escherichia coli and candida albicans respectively.
High-concentration chlorine dioxide has strong irritation, strong irritation and corrosion can be caused when the skin contacts or takes in high-concentration solution, and pyrrolidone iodine and other chemical disinfectants have the same general rule, and the sterilization effect of the pyrrolidone iodine is enhanced along with the increase of the content of effective iodine and the prolonging of the action time within a certain range. However, the effective iodine of the iodine-containing disinfectant has limited enhancement of the sterilization effect after reaching a certain concentration, and particularly, the capability of killing bacterial spores of the iodophor disinfectant is not obviously enhanced even if the concentration of the iodophor disinfectant is further increased. The dichlorobenzyl alcohol, the pyrrolidone iodine and the chlorine dioxide are compounded for use, the sterilization effects of the dichlorobenzyl alcohol, the pyrrolidone iodine and the chlorine dioxide can be fully utilized, the sterilization efficiency and the safety are improved, the low-concentration efficient sterilization and cleaning effects are achieved, and no stimulation or waste of stuffing is generated. In addition, chlorine dioxide is easy to decompose and cause explosion, the acid source and the alkali source react to generate carbon dioxide inert gas, the explosiveness of chlorine dioxide is reduced, and the safety is further improved.
The effervescent tablet adjuvant comprises surfactant, rhizoma Zingiberis recens extract, aloe extract, essential oil, stabilizer, catalyst and dry antiseptic. The effervescent tablet auxiliary materials comprise the following components in percentage by weight of the total amount of the effervescent tablets of the multifunctional skin disinfection cleaning solution: 10% -20% of surfactant, which can be but is not limited to 10%, 12%, 14%, 16%, 18% or 20%; ginger extract 5% -15%, can but not limited to 5%, 7%, 9%, 11%, 13% or 15%; aloe vera extract 5% -15%, which may be but is not limited to 5%, 7%, 9%, 11%, 13% or 15%; 5% -15% of essential oil, which can be but is not limited to 5%, 7%, 9%, 11%, 13% or 15%; 6% -15% of a stabilizer, which can be but is not limited to 6%, 7%, 9%, 11%, 13% or 15%; catalyst 0.1% -1%, can but not be limited to 2%, 3%, 4%, 5% or 6%; 0.1% -2% of drying agent, but not limited to 0.1%, 0.5%, 1%, 1.5% or 2%.
The surfactant is one or more of sodium lauryl sulfate, sodium fatty acid methyl ester sulfur, sodium lauryl polyether sulfate and natural soap powder, has good permeability and wettability, can promote the improvement of the use performance of the product when the product is used as a disinfectant, can reduce the surface tension of an aqueous solution, improves the wettability and permeability of the solution on the surface of an object, and enhances the sterilization and decontamination capability. The ginger extract has the obvious effect of inhibiting dermatophytes, and the aloe extract has the functions of sterilization, anti-inflammation, moistening and beautifying, immunity and regeneration, and also has the functions of analgesia and sedation, not only can promote the sterilization and cleaning effect, but also can play the roles of moisturizing, anti-inflammation and analgesia.
The essential oil is one or more selected from thymol thyme, caraway, sweet marjoram, savory, frankincense, red pine, black pepper, hemlock fir, clove, allspice, cajeput, citronella, lemon eucalyptus, lemon fine seed, ylang, peru balsam, jasmine, aromatic white bead and yellow birch essential oil. The essential oil has a local anesthetic effect and an anti-inflammatory analgesic effect with a certain time effect, when the skin has a wound surface and is cleaned by using the product, the essential oil can effectively slow down the impact on the wound surface to bring pain to people, and the essential oil and the aloe extract are matched for use, so that the effects of diminishing inflammation, relieving pain, accelerating wound healing and relieving pain can be achieved.
The stabilizer is sodium chloride, can increase the stability of the disinfectant, keep chemical balance, prevent light, thermal decomposition or oxidative decomposition and the like, and increase the effective period of the effervescent tablet. The catalyst may be manganese, and is used for catalyzing the reaction of the chlorite oxide and the halogen source, promoting the generation of chlorine dioxide and improving the yield of chlorine dioxide. The drying agent is anhydrous sodium sulfate, free water in a reaction composition system can be combined into stable crystal water, and the storage stability of the product is further improved.
A preparation method of the multifunctional skin disinfection cleaning solution effervescent tablet is used for preparing the multifunctional skin disinfection cleaning solution effervescent tablet, and comprises the following steps:
1) Mixing the chlorite and the halogen source according to the formula amount, adding the drying agent according to the formula amount, and mixing to obtain a mixture A;
2) Dissolving the acid source, the alkali source, the effervescent tablet auxiliary material and dichlorobenzyl alcohol in the formula amount in 95% ethanol, uniformly dispersing to form a mixed solvent, drying the mixed solvent to form dry blocks, volatilizing to remove ethanol, cooling and rolling the blocks, grinding and sieving to form a mixture B;
3) And mixing the mixture A and the mixture B, adding the pyrrolidone iodine, uniformly mixing, and tabletting by using an upper rotary tabletting machine to obtain the multifunctional skin disinfection cleaning solution effervescent tablet. 1. Detailed description of the preferred embodiments
Example 1
The embodiment provides a multifunctional skin disinfection cleaning solution effervescent tablet, which comprises the following raw materials in parts by weight: 7% of sodium chlorite, 3.5% of bleaching extract, 6% of pyrrolidone iodine, 0.25% of dichlorobenzyl alcohol, 18% of malic acid, 10% of sodium bicarbonate, 13% of sodium lauryl sulfate, 10% of ginger extract, 10% of aloe extract, 12% of frankincense essential oil, 9% of sodium chloride, 0.5% of catalyst and 0.75% of anhydrous sodium sulfate.
The preparation method comprises the following steps:
1) Mixing the sodium chlorite and the bleaching powder according to the formula amount, adding anhydrous sodium sulfate according to the formula amount, and mixing to obtain a mixture A;
2) Dissolving and uniformly dispersing the malic acid, the sodium bicarbonate, the sodium lauryl sulfate, the ginger extract, the aloe extract, the frankincense essential oil, the sodium chloride, the catalyst, the anhydrous sodium sulfate and the dichlorobenzyl alcohol in 95% ethanol to form a mixed solvent, drying the mixed solvent to form dry cakes, volatilizing to remove ethanol, cooling and rolling the cakes, grinding the cakes into powder and sieving to form a mixture B;
3) And mixing the mixture A and the mixture B, adding the pyrrolidone iodine, uniformly mixing, and tabletting by using an upper rotary tabletting machine to obtain the multifunctional skin disinfection cleaning solution effervescent tablet.
Example 2
The embodiment provides a multifunctional skin disinfection cleaning solution effervescent tablet, which comprises the following raw materials in parts by weight: 5% of sodium chlorite, 2.5% of bleaching extract, 6% of pyrrolidone iodine, 0.25% of dichlorobenzyl alcohol, 18% of malic acid, 10% of sodium bicarbonate, 13% of sodium lauryl sulfate, 11% of ginger extract, 11% of aloe extract, 13% of frankincense essential oil, 9% of sodium chloride, 0.5% of catalyst and 0.75% of anhydrous sodium sulfate.
The preparation method comprises the following steps:
1) Mixing the sodium chlorite and the bleaching powder according to the formula amount, adding anhydrous sodium sulfate according to the formula amount, and mixing to obtain a mixture A;
2) Dissolving the malic acid, the sodium bicarbonate, the sodium lauryl sulfate, the ginger extract, the aloe extract, the frankincense essential oil, the sodium chloride, the catalyst, the anhydrous sodium sulfate and the dichlorobenzyl alcohol in 95% ethanol according to the formula ratio, uniformly dispersing to form a mixed solvent, drying the mixed solvent to form dry cakes, volatilizing to remove the ethanol, cooling and rolling the cakes, grinding the cakes and sieving to form a mixture B;
3) And mixing the mixture A and the mixture B, then adding the pyrrolidone iodine, uniformly mixing, and tabletting by rotating a tabletting machine up to obtain the multifunctional skin disinfection cleaning solution effervescent tablets.
Example 3
The embodiment provides a multifunctional skin disinfection cleaning solution effervescent tablet which comprises the following raw materials in parts by weight: 10% of sodium chlorite, 5% of bleaching essence, 6% of pyrrolidone iodine, 0.25% of dichlorobenzyl alcohol, 18% of malic acid, 10% of sodium bicarbonate, 13% of sodium lauryl sulfate, 8% of ginger extract, 8% of aloe extract, 11.5% of frankincense essential oil, 9% of sodium chloride, 0.5% of catalyst and 0.75% of anhydrous sodium sulfate.
The preparation method comprises the following steps:
1) Mixing the sodium chlorite and the bleaching powder according to the formula amount, adding anhydrous sodium sulfate according to the formula amount, and mixing to obtain a mixture A;
2) Dissolving and uniformly dispersing the malic acid, the sodium bicarbonate, the sodium lauryl sulfate, the ginger extract, the aloe extract, the frankincense essential oil, the sodium chloride, the catalyst, the anhydrous sodium sulfate and the dichlorobenzyl alcohol in 95% ethanol to form a mixed solvent, drying the mixed solvent to form dry cakes, volatilizing to remove ethanol, cooling and rolling the cakes, grinding the cakes into powder and sieving to form a mixture B;
3) And mixing the mixture A and the mixture B, adding the pyrrolidone iodine, uniformly mixing, and tabletting by using an upper rotary tabletting machine to obtain the multifunctional skin disinfection cleaning solution effervescent tablet.
Example 4
The embodiment provides a multifunctional skin disinfection cleaning solution effervescent tablet, which comprises the following raw materials in parts by weight: 7% of sodium chlorite, 3.5% of bleaching extract, 3% of pyrrolidone iodine, 0.25% of dichlorobenzyl alcohol, 18% of malic acid, 10% of sodium bicarbonate, 13% of sodium lauryl sulfate, 11% of ginger extract, 11% of aloe extract, 13% of frankincense essential oil, 9% of sodium chloride, 0.5% of catalyst and 0.75% of anhydrous sodium sulfate.
The preparation method comprises the following steps:
1) Mixing the sodium chlorite and the bleaching powder according to the formula amount, adding anhydrous sodium sulfate according to the formula amount, and mixing to obtain a mixture A;
2) Dissolving and uniformly dispersing the malic acid, the sodium bicarbonate, the sodium lauryl sulfate, the ginger extract, the aloe extract, the frankincense essential oil, the sodium chloride, the catalyst, the anhydrous sodium sulfate and the dichlorobenzyl alcohol in 95% ethanol to form a mixed solvent, drying the mixed solvent to form dry cakes, volatilizing to remove ethanol, cooling and rolling the cakes, grinding the cakes into powder and sieving to form a mixture B;
3) And mixing the mixture A and the mixture B, adding the pyrrolidone iodine, uniformly mixing, and tabletting by using an upper rotary tabletting machine to obtain the multifunctional skin disinfection cleaning solution effervescent tablet.
Example 5
The embodiment provides a multifunctional skin disinfection cleaning solution effervescent tablet, which comprises the following raw materials in parts by weight: 7% of sodium chlorite, 3.5% of bleaching extract, 8% of pyrrolidone iodine, 0.25% of dichlorobenzyl alcohol, 18% of malic acid, 10% of sodium bicarbonate, 13% of sodium lauryl sulfate, 9% of ginger extract, 9% of aloe extract, 12% of frankincense essential oil, 9% of sodium chloride, 0.5% of catalyst and 0.75% of anhydrous sodium sulfate.
The preparation method comprises the following steps:
1) Mixing the sodium chlorite and the bleaching powder according to the formula amount, adding anhydrous sodium sulfate according to the formula amount, and mixing to obtain a mixture A;
2) Dissolving the malic acid, the sodium bicarbonate, the sodium lauryl sulfate, the ginger extract, the aloe extract, the frankincense essential oil, the sodium chloride, the catalyst, the anhydrous sodium sulfate and the dichlorobenzyl alcohol in 95% ethanol according to the formula ratio, uniformly dispersing to form a mixed solvent, drying the mixed solvent to form dry cakes, volatilizing to remove the ethanol, cooling and rolling the cakes, grinding the cakes and sieving to form a mixture B;
3) And mixing the mixture A and the mixture B, adding the pyrrolidone iodine, uniformly mixing, and tabletting by using an upper rotary tabletting machine to obtain the multifunctional skin disinfection cleaning solution effervescent tablet.
Example 6
The embodiment provides a multifunctional skin disinfection cleaning solution effervescent tablet, which comprises the following raw materials in parts by weight: 7% of sodium chlorite, 3.5% of bleaching extract, 6% of pyrrolidone iodine, 0.1% of dichlorobenzyl alcohol, 18% of malic acid, 10% of sodium bicarbonate, 13% of sodium lauryl sulfate, 10% of ginger extract, 10% of aloe extract, 12% of frankincense essential oil, 9% of sodium chloride, 0.5% of catalyst and 0.9% of anhydrous sodium sulfate.
The preparation method comprises the following steps:
1) Mixing the sodium chlorite and the bleaching powder according to the formula amount, adding anhydrous sodium sulfate according to the formula amount, and mixing to obtain a mixture A;
2) Dissolving and uniformly dispersing the malic acid, the sodium bicarbonate, the sodium lauryl sulfate, the ginger extract, the aloe extract, the frankincense essential oil, the sodium chloride, the catalyst, the anhydrous sodium sulfate and the dichlorobenzyl alcohol in 95% ethanol to form a mixed solvent, drying the mixed solvent to form dry cakes, volatilizing to remove ethanol, cooling and rolling the cakes, grinding the cakes into powder and sieving to form a mixture B;
3) And mixing the mixture A and the mixture B, adding the pyrrolidone iodine, uniformly mixing, and tabletting by using an upper rotary tabletting machine to obtain the multifunctional skin disinfection cleaning solution effervescent tablet.
Example 7
The embodiment provides a multifunctional skin disinfection cleaning solution effervescent tablet, which comprises the following raw materials in parts by weight: 7% of sodium chlorite, 3.5% of bleaching extract, 6% of pyrrolidone iodine, 0.3% of dichlorobenzyl alcohol, 18% of malic acid, 10% of sodium bicarbonate, 13% of sodium lauryl sulfate, 10% of ginger extract, 10% of aloe extract, 12% of frankincense essential oil, 9% of sodium chloride, 0.5% of catalyst and 0.7% of anhydrous sodium sulfate.
The preparation method comprises the following steps:
1) Mixing the sodium chlorite and the bleaching powder according to the formula amount, adding anhydrous sodium sulfate according to the formula amount, and mixing to obtain a mixture A;
2) Dissolving and uniformly dispersing the malic acid, the sodium bicarbonate, the sodium lauryl sulfate, the ginger extract, the aloe extract, the frankincense essential oil, the sodium chloride, the catalyst, the anhydrous sodium sulfate and the dichlorobenzyl alcohol in 95% ethanol to form a mixed solvent, drying the mixed solvent to form dry cakes, volatilizing to remove ethanol, cooling and rolling the cakes, grinding the cakes into powder and sieving to form a mixture B;
3) And mixing the mixture A and the mixture B, adding the pyrrolidone iodine, uniformly mixing, and tabletting by using an upper rotary tabletting machine to obtain the multifunctional skin disinfection cleaning solution effervescent tablet.
Example 8
The embodiment provides a multifunctional skin disinfection cleaning solution effervescent tablet which comprises the following raw materials in parts by weight: 5% of sodium chlorite, 2% of bleaching essence, 3% of pyrrolidone iodine, 0.1% of dichlorobenzyl alcohol, 10% of malic acid, 5% of sodium bicarbonate, 17% of sodium lauryl sulfate, 15% of ginger extract, 15% of aloe extract, 15% of frankincense essential oil, 12% of sodium chloride, 0.1% of catalyst and 0.8% of anhydrous sodium sulfate.
The preparation method comprises the following steps:
1) Mixing the sodium chlorite and the bleaching powder according to the formula amount, adding anhydrous sodium sulfate according to the formula amount, and mixing to obtain a mixture A;
2) Dissolving and uniformly dispersing the malic acid, the sodium bicarbonate, the sodium lauryl sulfate, the ginger extract, the aloe extract, the frankincense essential oil, the sodium chloride, the catalyst, the anhydrous sodium sulfate and the dichlorobenzyl alcohol in 95% ethanol to form a mixed solvent, drying the mixed solvent to form dry cakes, volatilizing to remove ethanol, cooling and rolling the cakes, grinding the cakes into powder and sieving to form a mixture B;
3) And mixing the mixture A and the mixture B, adding the pyrrolidone iodine, uniformly mixing, and tabletting by using an upper rotary tabletting machine to obtain the multifunctional skin disinfection cleaning solution effervescent tablet.
Example 9
The embodiment provides a multifunctional skin disinfection cleaning solution effervescent tablet, which comprises the following raw materials in parts by weight: 10% of sodium chlorite, 6% of bleaching essence, 8% of pyrrolidone iodine, 0.3% of dichlorobenzyl alcohol, 20% of malic acid, 12% of sodium bicarbonate, 10% of sodium lauryl sulfate, 7% of ginger extract, 7% of aloe extract, 9% of frankincense essential oil, 9% of sodium chloride, 1% of catalyst and 0.7% of anhydrous sodium sulfate.
The preparation method comprises the following steps:
1) Mixing the sodium chlorite and the bleaching powder according to the formula amount, adding anhydrous sodium sulfate according to the formula amount, and mixing to obtain a mixture A;
2) Dissolving and uniformly dispersing the malic acid, the sodium bicarbonate, the sodium lauryl sulfate, the ginger extract, the aloe extract, the frankincense essential oil, the sodium chloride, the catalyst, the anhydrous sodium sulfate and the dichlorobenzyl alcohol in 95% ethanol to form a mixed solvent, drying the mixed solvent to form dry cakes, volatilizing to remove ethanol, cooling and rolling the cakes, grinding the cakes into powder and sieving to form a mixture B;
3) And mixing the mixture A and the mixture B, adding the pyrrolidone iodine, uniformly mixing, and tabletting by using an upper rotary tabletting machine to obtain the multifunctional skin disinfection cleaning solution effervescent tablet.
Comparative example 1
The embodiment provides a multifunctional skin disinfection cleaning solution effervescent tablet, which comprises the following raw materials in parts by weight: pyrrolidone iodine 8%, dichlorobenzyl alcohol 0.3%, malic acid 20%, sodium bicarbonate 12%, sodium lauryl sulfate 14%, ginger extract 11%, aloe extract 11%, frankincense essential oil 13%, sodium chloride 10% and anhydrous sodium sulfate 0.7%.
The preparation method comprises the following steps:
1) Mixing the sodium chlorite and the bleaching powder according to the formula amount, adding anhydrous sodium sulfate according to the formula amount, and mixing to obtain a mixture A;
2) Dissolving the malic acid, the sodium bicarbonate, the sodium lauryl sulfate, the ginger extract, the aloe extract, the frankincense essential oil, the sodium chloride, the catalyst, the anhydrous sodium sulfate and the dichlorobenzyl alcohol in 95% ethanol according to the formula ratio, uniformly dispersing to form a mixed solvent, drying the mixed solvent to form dry cakes, volatilizing to remove the ethanol, cooling and rolling the cakes, grinding the cakes and sieving to form a mixture B;
3) And mixing the mixture A and the mixture B, adding the pyrrolidone iodine, uniformly mixing, and tabletting by using an upper rotary tabletting machine to obtain the multifunctional skin disinfection cleaning solution effervescent tablet.
Comparative example 2
The embodiment provides a multifunctional skin disinfection cleaning solution effervescent tablet, which comprises the following raw materials in parts by weight: 8% of sodium chlorite, 4% of bleaching extract, 0.3% of dichlorobenzyl alcohol, 18% of malic acid, 10% of sodium bicarbonate, 13% of sodium lauryl sulfate, 11% of ginger extract, 12% of aloe extract, 13.5% of frankincense essential oil, 9% of sodium chloride, 0.5% of catalyst and 0.7% of anhydrous sodium sulfate.
The preparation method comprises the following steps:
1) Mixing the sodium chlorite and the bleaching powder according to the formula amount, adding anhydrous sodium sulfate according to the formula amount, and mixing to obtain a mixture A;
2) Dissolving and uniformly dispersing the malic acid, the sodium bicarbonate, the sodium lauryl sulfate, the ginger extract, the aloe extract, the frankincense essential oil, the sodium chloride, the catalyst, the anhydrous sodium sulfate and the dichlorobenzyl alcohol in 95% ethanol to form a mixed solvent, drying the mixed solvent to form dry cakes, volatilizing to remove ethanol, cooling and rolling the cakes, grinding the cakes into powder and sieving to form a mixture B;
3) And mixing the mixture A and the mixture B, then adding the pyrrolidone iodine, uniformly mixing, and tabletting by rotating a tabletting machine up to obtain the multifunctional skin disinfection cleaning solution effervescent tablets.
Comparative example 3
The embodiment provides a multifunctional skin disinfection cleaning solution effervescent tablet, which comprises the following raw materials in parts by weight: 7% of sodium chlorite, 3.5% of bleaching extract, 6% of pyrrolidone iodine, 18% of malic acid, 10% of sodium bicarbonate, 13% of sodium lauryl sulfate, 10% of ginger extract, 10% of aloe extract, 12% of frankincense essential oil, 9% of sodium chloride, 0.5% of catalyst and 1% of anhydrous sodium sulfate.
The preparation method comprises the following steps:
1) Mixing the sodium chlorite and the bleaching powder according to the formula amount, adding anhydrous sodium sulfate according to the formula amount, and mixing to obtain a mixture A;
2) Dissolving the malic acid, the sodium bicarbonate, the sodium lauryl sulfate, the ginger extract, the aloe extract, the frankincense essential oil, the sodium chloride, the catalyst, the anhydrous sodium sulfate and the dichlorobenzyl alcohol in 95% ethanol according to the formula ratio, uniformly dispersing to form a mixed solvent, drying the mixed solvent to form dry cakes, volatilizing to remove the ethanol, cooling and rolling the cakes, grinding the cakes and sieving to form a mixture B;
3) And mixing the mixture A and the mixture B, adding the pyrrolidone iodine, uniformly mixing, and tabletting by using an upper rotary tabletting machine to obtain the multifunctional skin disinfection cleaning solution effervescent tablet.
2. Detection of
Quantitative sterilization test of suspension
(1) Selecting three strains of staphylococcus aureus, escherichia coli and saccharomycetes, and preparing bacterial suspensions for tests according to disinfection technical specifications respectively, wherein the concentration is 1 x 108 cfu/ml-3 x 108cfu/ml.
(2) And 10 sterile large test tubes for detoxification test are added with 0.5ml of bacterial suspension, then 0.5ml of organic interfering substance is added, the mixture is mixed evenly, and after the mixture is placed in a water bath at the temperature of 20 ℃ for 5min, 4ml of effervescent solution prepared by the effervescent tablets prepared in the examples and the comparative examples is added by a sterile pipette, and the mixture is mixed evenly and timed quickly.
(3) And (3) when the test bacteria and the effervescent liquid interact for 1min, 5min and 10min, respectively sucking 0.5ml of test bacteria and the effervescent liquid, adding 4.5ml of sterilized neutralizing agent, and uniformly mixing.
(4) Adding neutralizing agent into the test bacteria and effervescent solution, reacting for 10min, respectively sucking 1.0m1 sample solution, determining viable bacteria number by viable bacteria culture counting method, and inoculating 2 plates to each tube of sample solution. If the number of colonies growing on the plate is large, the plate can be diluted with sterile water in a gradient manner, viable bacteria culture counting is carried out, and the number of viable bacteria in the sterile water solution is measured by a viable bacteria culture counting method and is used as a negative control.
(5) All test samples were cultured in a 37 ℃ incubator, and the final results were observed for 48h of bacterial propagule culture and 72h of bacterial spore culture.
(6) Repeating the test for 3 times, adding the viable count of each group, taking an average value, and calculating the sterilization rate;
sterilization ratio =1- (viable bacteria number × 10 × 5 × dilution factor/bacterial suspension concentration × 100%)
The test results are shown in table 1.
TABLE 1 aqueous solution sterilization rate of multifunctional skin disinfectant cleaning solution effervescent tablets
As shown in table 1, the sterilization rate of the effervescent solution obtained by dissolving the effervescent tablets of the multifunctional skin disinfection cleaning solution prepared in examples 1-7 in water is above 99.95%, even up to 99.99%, which indicates that the effervescent tablets of the multifunctional skin disinfection cleaning solution have good sterilization effect. The multifunctional skin disinfection cleaning solution effervescent tablet prepared in the embodiment 1 has relatively good sterilization efficiency and effect.
Multifunctional skin disinfection cleaning solution effervescent tablet sterilization stability test
(1) Preparing the effervescent tablet prepared in the example 1 into effervescent liquid, and placing the effervescent liquid in a normal indoor environment;
(2) Respectively taking the effervescent liquid which is placed for 1d, 5d, 10d, 15d, 20d and 30d according to the quantitative sterilization test of the suspension for performing the sterilization test, wherein the interaction of the test bacteria and the effervescent liquid is 5min, and the sterilization rate is obtained as shown in the table 2;
TABLE 2 test results of the sterilization stability of the effervescent tablets of the multifunctional skin disinfection and cleaning solution
| Staphylococcus aureus | Escherichia coli | Yeast | |
| 1d | 99.96 | 99.97 | 99.97 |
| 5d | 99.97 | 99.97 | 99.98 |
| 10d | 99.96 | 99.98 | 99.97 |
| 15d | 99.96 | 99.97 | 99.96 |
| 20d | 99.95 | 99.97 | 99.97 |
| 30d | 99.93 | 99.95 | 99.95 |
As can be seen from Table 2, the effervescent solution still has a high sterilization rate after the effervescent tablet is dissolved and changed into the effervescent solution for 30 days, which shows that the multifunctional skin disinfection cleaning solution effervescent tablet has good effective stability.
The use method of the multifunctional skin disinfection cleaning solution effervescent tablet comprises the following steps:
get a slice of multi-functional skin disinfection cleaning solution effervescent tablet (3 g) and put into the bottle that is equipped with 250ml water, this multi-functional skin disinfection cleaning solution effervescent tablet dissolves in water after a minute, obtain a multi-functional skin disinfection cleaning solution effervescent tablet aqueous solution, can use the push type bubble bottle dress, press and extrude the foam and carry out skin cleaning, or spray the bottle dress with the push type, press the blowout liquid and carry out skin cleaning, or directly with ordinary bottled, directly pour liquid and carry out skin cleaning.
The invention compounds dichlorobenzyl alcohol with pyrrolidone iodine and chlorine dioxide for use, fully utilizes the sterilization effects of the dichlorobenzyl alcohol, the pyrrolidone iodine and the chlorine dioxide, achieves the effect of low-concentration high sterilization effect, improves the sterilization efficiency and the safety of the effervescent tablet, ensures that the effervescent tablet has the effect of high-efficiency sterilization and cleaning, does not have stimulation or waste of stuffing of raw materials, ensures that the effervescent liquid obtained after the dissolution of the effervescent tablet can play a quick and lasting sterilization effect on common gram-positive bacteria, gram-negative bacteria fungi and the like, has good sterilization and disinfection effects and good sterilization and disinfection effect stability, in addition, the ginger extract is added in the effervescent tablet, further promotes the bacteriostasis effect of the product, has the functions of sterilization and disinfection while the aloe extract is added, also has the functions of moisture preservation, inflammation resistance and pain resistance, relieves the problem of desquamation and dryness caused by a plurality of hand washing to a certain extent, and in addition, the essential oil with the effects of anesthesia, inflammation resistance and pain resistance is added, and can effectively slow down pain feeling brought to people caused by the impact of a wound surface, and relieve the pain. The invention has good sterilization and disinfection effects and high safety, is suitable for common daily life, also meets the requirements of medical care or skin cleaning and disinfection of patients, and has wide application range and good use effect.
While the invention has been described in connection with what is presently considered to be the most practical and preferred embodiment, it is to be understood that the invention is not to be limited to the disclosed embodiment, but on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims.
Claims (5)
1. The multifunctional effervescent tablet of the skin disinfection cleaning solution is characterized by comprising the following raw materials in parts by weight:
5 to 10 percent of chlorite, 2 to 6 percent of halogen source, 3 to 8 percent of pyrrolidone iodine, 0.1 to 0.3 percent of dichlorobenzyl alcohol, 10 to 20 percent of acid source, 5 to 12 percent of alkali source and the balance of effervescent tablet auxiliary materials;
the acid source is one or more selected from citric acid and malic acid; the alkali source is selected from one or more of sodium bicarbonate, sodium carbonate, potassium bicarbonate and calcium carbonate;
the effervescent tablet auxiliary materials comprise a surfactant, a ginger extract, an aloe extract, essential oil, a stabilizer, a catalyst and a dry preservative, and the effervescent tablet auxiliary materials comprise the following components in percentage by weight: 10 to 20 percent of surfactant, 5 to 15 percent of ginger extract, 5 to 15 percent of aloe extract, 5 to 15 percent of essential oil, 6 to 15 percent of stabilizer, 0.1 to 1 percent of catalyst and 0.1 to 2 percent of desiccant;
the stabilizer is sodium chloride.
2. The effervescent tablet of multifunctional skin disinfection and cleansing fluid as claimed in claim 1, wherein the essential oil is selected from one or more of thymol thyme, caraway, sweet marjoram, savory, frankincense, red pine, black pepper, hemlock, clove, allspice, cajeput, citronella, lemon eucalyptus, lemon fine seed, ylang, peruvian balsam, jasmine, aromatic white pearl, yellow birch essential oil.
3. The effervescent tablet of multifunctional skin disinfection and cleaning solution as claimed in claim 1, wherein the surfactant is one or more of sodium lauryl sulfate, sodium fatty acid methyl ester sulfate, sodium laureth sulfate and natural soap powder.
4. The effervescent tablet of multifunctional skin disinfection cleaning solution as claimed in any one of claims 1-3, which comprises the following raw materials in parts by weight:
chlorite 7%, halogen source 3.5%, pyrrolidone iodine 6%, dichlorobenzyl alcohol 0.25%, acid source 18%, alkali source 10%, and effervescent tablet supplementary material in balance.
5. A method for preparing the multifunctional skin disinfection cleaning solution effervescent tablet according to any one of claims 1-4, which comprises the following steps:
1) Mixing the chlorite and the halogen source according to the formula amount, adding the drying agent according to the formula amount, and mixing to obtain a mixture A;
2) Dissolving the acid source, the alkali source, the effervescent tablet auxiliary material and dichlorobenzyl alcohol in the formula amount in 95% ethanol, uniformly dispersing to form a mixed solvent, drying the mixed solvent to form dry blocks, volatilizing to remove ethanol, cooling and rolling the blocks, grinding and sieving to form a mixture B;
4) And mixing the mixture A and the mixture B, adding the pyrrolidone iodine, uniformly mixing, and tabletting by using an upper rotary tabletting machine to obtain the multifunctional skin disinfection cleaning solution effervescent tablet.
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| US6114396A (en) * | 1995-08-22 | 2000-09-05 | Optident International Ltd. | Sterilizing or disinfecting composition |
| CN102283246A (en) * | 2011-05-30 | 2011-12-21 | 石家庄科大绿源科技发展有限公司 | Solid chlorine dioxide effervescent tablet and preparation method thereof |
| CN104138390A (en) * | 2014-06-11 | 2014-11-12 | 龚佳郎 | Chlorine dioxide effervescent tablet for killing barbier bacteria and fungi and preparation method thereof |
| CN106561707A (en) * | 2016-10-31 | 2017-04-19 | 郑州普罗动物药业有限公司 | Povidone iodine effervescent tablet with sterilization and disinfection effects, and preparation method thereof |
| CN110538161A (en) * | 2019-09-29 | 2019-12-06 | 石家庄卫科生物科技有限公司 | povidone iodine effervescent tablet for animal delivery room and preparation method thereof |
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| US6114396A (en) * | 1995-08-22 | 2000-09-05 | Optident International Ltd. | Sterilizing or disinfecting composition |
| CN102283246A (en) * | 2011-05-30 | 2011-12-21 | 石家庄科大绿源科技发展有限公司 | Solid chlorine dioxide effervescent tablet and preparation method thereof |
| CN104138390A (en) * | 2014-06-11 | 2014-11-12 | 龚佳郎 | Chlorine dioxide effervescent tablet for killing barbier bacteria and fungi and preparation method thereof |
| CN106561707A (en) * | 2016-10-31 | 2017-04-19 | 郑州普罗动物药业有限公司 | Povidone iodine effervescent tablet with sterilization and disinfection effects, and preparation method thereof |
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