CN1751577A - Composite sterilizing agent contg. silver and zinc, prepn. method and application thereof - Google Patents
Composite sterilizing agent contg. silver and zinc, prepn. method and application thereof Download PDFInfo
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- CN1751577A CN1751577A CN 200410080151 CN200410080151A CN1751577A CN 1751577 A CN1751577 A CN 1751577A CN 200410080151 CN200410080151 CN 200410080151 CN 200410080151 A CN200410080151 A CN 200410080151A CN 1751577 A CN1751577 A CN 1751577A
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Abstract
A composite bactericide containing Ag and Zn ions for preparing antibacterial materials, the medicines to prevent and treat the infection of fungus or bacteria to genetic tract of woman and skin, the lotion for eye and hand, detergent, etc is prepared through preparing the Ag contained aqueous solution from silver oxide, regulating pH=1-5, adding hydrogen peroxide to obtain the aqueous solution containing high-valence Ag ions, and adding the soluble Zn salt.
Description
Technical field
What the present invention relates to is bactericide, particularly relates to a kind of argentiferous, zinc composite sterilizing agent and preparation method thereof and application.
Background technology
Since inorganic antiseptic have antibiotic wide spectrum, lastingly, safely, characteristics such as have no drug resistance, so people are more and more paid attention to by many countries with using its research.Many studies have shown that, metal ion have antibiotic, sterilization functions, and wherein silver has been used the history of more than one thousand years nearly as the representative of antibacterial metal.People are summarized as follows the antibiotic mechanism of silver: 1, silver and sulfydryl in the pathogenic bacteria metabolic enzyme combine, and make enzyme deactivation, cause pathogenic bacteria not energy metabolism and death; 2, the peptide glycan reaction that exposes on silver and the bacteria cell wall forms the invertibity compound, makes it not advance cell to oxygen transport, stops the germ activity, causes its death; 3, the DNA base combination in silver ion and the pathogenic bacteria, silver ion forms cross-linked each other, causes the dna structure sex change, suppresses it and duplicates, and makes the pathogenic bacteria inactivation.Along with the further investigation of people to silver-colored anti-microbial property, find that the anti-microbial property of silver and the valence state of silver have very confidential relation, the high more antibacterial ability of valence state of silver is strong more, wherein divalence silver and trivalent silver bactericidal effect is 50～200 times of the silver-colored and argent of monovalence, and the sterilization speed of trivalent silver compound is than silver-colored fast 240 times of (the Soap/Cosmetics/Chemical Specialties of monovalence, March, 1994, page52).Prior art studies show that the metal ion antibacterial ability is Ag
4+＞Ag
3+＞Ag
2+＞Ag
+＞Cu
2+＞Zn
2+＞Fe
3+
The inventor's research has also proved argentic sterilization ability greater than at a low price silver-colored (as shown in table 1), so the exploitation and the application of our special concern high price silver ion.
Table 1
| Valence state (compound) | Ag％ | Zn％ | To Candida albicans sterilizing rate % (10 minutes; 6.6 * 10 5cfu/ml) |
| Ag +(AgAc) | 0.01 | 0 | 87.31 |
| Ag 4+(H 4Ag 2O 6) | 0.01 | 0 | 98.05 |
Though a lot of in the prior art to the antibiotic research of silver, be the inorganic antibacterial material or the silver oxide of lower valency silver mostly, have only the inventor's Chinese patent ZL97108681.8 for the research of high valence state silver solution.The exploitation of high price Ag-containing solution makes the purposes of silver more extensive.Yet find that in application process though silver is broad spectrum antimicrobicide, it is desirable not enough to the antibacterial effect such as fungi and mould etc.
Zinc element is confirmed already in application pharmaceutically, as all effective in cure to wound healing, stomatitis, skin damage type papule, warts, erosive dermatitis etc.Zinc also is a kind of traditional inorganic fungicide.Zinc is as anti-biotic material, and it is inchoate in recent years being paid attention to by people.Though the antibacterial ability of zinc ion is not as good as any silver ion, the zinc ion antifungi is can the force rate silver ion strong, and is will zinc ion eager to excel in whatever one does to the more independent silver ion of the sterilization effect of fungi and mould with silver ion combination back.
Silver and zinc is compound as anti-biotic material, existing report in the prior art, Chinese patent 00112519.2 discloses a kind of silver zinc combined antimicrobial agent, by amino acid silver and amino-acid zinc, with and the argent that decompose to generate, zinc oxide is formed the antibiotic property motif material of antibacterial agent.Though this technology is combined as antibacterial agent with silver and zinc, but the concentration of its silver ion is low, the valence state of silver is also low, so its anti-microbial property is restricted, and what it played antibacterial action mainly is argent and zinc oxide, as everyone knows, the anti-microbial property of silver and zinc mainly is that silver ion and zinc ion work, so this technology is used significant limitation is arranged.
Summary of the invention
At the problems referred to above, the purpose of this invention is to provide a kind of composite bactericidal agent that contains high price silver ion and zinc ion.
Another object of the present invention provides a kind of method and application for preparing argentiferous, zinc composite sterilizing agent.
For achieving the above object, the present invention takes following technical scheme: a kind of argentiferous, zinc composite sterilizing agent prepare by the following method: the oxide of silver is mixed with silver-containing solution, regulates pH value to 1～5; In silver-containing solution, add hydrogen oxide, be mixed with the aqueous solution that contains the high price silver ion; Soluble zinc salt is joined in the aqueous solution that contains the high price silver ion again, promptly become the composite sterilizing agent of argentiferous, zinc, the ratio of weight and number of described zinc ion and silver ion is a silver ion: zinc ion=1: 1～100.
The implication of high price silver ion is the general name of divalent, 3 valencys and 4 valency silver ions.
A kind of method for preparing argentiferous, zinc composite sterilizing agent may further comprise the steps: 1. with the oxide and the oxide of deionized water according to silver of silver: the ratio of weight and number of deionized water=1: 200 mixes, and is mixed with silver-containing solution; 2. after stirring silver-containing solution 15 minutes～2 hours, regulate pH value to 1～5 of silver-containing solution; 3. be 1～30% hydrogen peroxide with concentration according to the oxide of ratio of weight and number for silver: hydrogen peroxide=1: 1～100 join in the silver-containing solution, are mixed with to contain the argentic aqueous solution; 4. according to silver ion: the soluble zinc salt of the ratio of weight and number of zinc ion=1: 1～100 joins and contains in the argentic aqueous solution, obtains the composite sterilizing agent of argentiferous, zinc.
The oxide of described silver is silver peroxide (Ag
2O
2) or silver oxide (Ag
2O).
Described concentrated acid comprises perchloric acid, sulfuric acid, nitric acid, citric acid, acetate, acetic acid, malic acid, lactic acid or carbonic acid.
Described soluble zinc salt is selected from zinc sulphate, zinc nitrate, zinc acetate, zinc lactate, zinc gluconate, ethylenediamine tetra-acetic acid zinc, zinc malate or zinc citrate; The addition of zinc ion is 1～100 times of silver ion content in the described composite sterilizing agent.
Argentiferous, zinc composite sterilizing agent can be used for making dental care products.
Described dental care products comprise toothpaste, collutory, oral spray, tooth powder, tooth gel and chewing gum.
Argentiferous, zinc composite sterilizing agent can be used for preparing the control women ' s genital tract infection, superficial skin fungus infects and the medicine of skin trauma.
Described women ' s genital tract infection comprises monilial vaginitis, senile vahinitis, bacterial vaginosis BV, trichomonas vaginitis, Combination vaginitis, wound healing after chronic cervicitis, the cervical erosion physical treatment, mycoplasma choamydiae infection, gonococcal infection; Described superficial skin fungus infects and comprises acne, acne, whelk, ringworm of the body, the ringworm of the foot, the tinea manuum, favus of the scalp, jock itch, trichophytosis, onychomycosis and vinasse nose; Described skin trauma comprises burn and scald wound, surgery damage wound, surgical wound and chronic surface ulcers.
Argentiferous, zinc composite sterilizing agent can be used for preparing anti-biotic material.
Described anti-biotic material comprises that with yarn fabric or nonwoven or inorganic mineral be that the inoganic solids anti-biotic material of carrier, organic solid anti-biotic material and the plastics that organic material is carrier are the antibiotic plastic of carrier.
Described inorganic mineral is selected from one or more in calcium carbonate, zeolite, silica, calcium phosphate, calcium dihydrogen phosphate, apatite, hydroxyapatite, fluor-apatite, white carbon black, calcium phosphate dibasic dihydrate, hydration silica, calcium pyrophosphate, tricalcium phosphate, sepiolite, active carbon, basic zirconium phosphate, titanium dioxide, kaolin, bentonite, chalky soil, calcium lactate, calcium citrate, calcium gluconae, montmorillonite or the graphite.
Argentiferous, zinc composite sterilizing agent can be used for preparing collyrium, hand cleanser, family expenses cleaning agent and contact lenses conditioning liquid.
Argentiferous, zinc composite sterilizing agent can be used for medicine equipment, sterilizing article, amenities and cosmetics.
The antibacterial agent that the present invention relates to is the composite bactericidal agent of high price silver ion and zinc ion.The purpose that adds zinc in the agent of argentiferous composite bactericidal singly is not in order to improve the weather resisteant of silver, the more important thing is the synergy that is their sterilizations, studies show that, when the proportioning of zinc ion and silver ion reach one regularly its sterilization functions increase greatly, shown in table 2, table 3.
Table 2
| Valence state (compound) | Ag％ | Zn％ | To Candida albicans sterilizing rate % (10 minutes 6.6 * 10 5cfu/ml) |
| Ag +(AgAc) | 0.01 | 0 | 87.31 |
| Ag 4+(H 4Ag 2O 6) | 0.01 | 0 | 98.05 |
| Ag 4+(H 4Ag 2O 6) | 0.01 | 1.0 | 99.99 |
Table 3
| NO | Ag％(Ag 4+) | Zn％ | To Candida albicans sterilizing rate % (10 minutes 5.25 * 10 5cfu/ml) |
| 1 | 0.01 | 0 | 97.45 |
| 2 | 0.01 | 0.01 | 99.72 |
| 3 | 0.01 | 0.03 | 99.95 |
| 4 | 0.01 | 0.05 | 99.91 |
| 5 | 0.01 | 0.10 | 99.85 |
| 6 | 0.01 | 0.20 | 99.57 |
| 7 | 0.01 | 0.30 | 98.10 |
| 8 | 0.01 | 0.50 | 97.70 |
| 9 | 0.01 | 1.0 | 97.30 |
Advantage of the present invention is, manufacture craft is simple, cycle is short, cost is low, it is higher that the gained bactericide contains the valence state and the concentration of silver ion, and there is zinc ion to act synergistically, sterilizing ability to all kinds of pathogenic bacteria especially fungi and mould is stronger, sterilization speed is faster, in addition, silver-colored zinc composite sterilizing agent of the present invention can mix with water with arbitrary proportion, and safety and stability are high, be a kind of desirable compound broad-spectrum sterilization material of silver-colored zinc, it can be more extensive in all kinds of antimicrobial products of suitability for industrialized production and application.
Embodiment
Embodiment 1: the preparation of high concentration argentiferous, zinc compound disinfectant mother liquor.
With silver peroxide 500 grams, put into reaction pot, add 100 kilograms of deionized waters, be mixed with silver-containing solution; Stir silver-containing solution after 15 minutes, add 125 milliliters in perchloric acid, the pH value of regulating silver-containing solution is 2; Continue stirring then 2 hours, is 600 milliliters of 15% hydrogen peroxide when the pH value stabilization dropwise adds concentration 2 the time again, stirs 30 minutes again; Add this moment contain the zinc nitrates that zinc ion is 2200 grams (zinc nitrate that is added is chloride ion-containing not, can not contain other can with the anion of silver ion generation chemical reaction), stirred again 30 minutes, promptly be mixed with high concentration compound disinfectant mother liquor.The weight of contained silver ion accounts for 0.4% of mother liquor weight in the compound disinfectant mother liquor, and the weight of contained zinc ion accounts for 2% of mother liquor weight in the compound disinfectant mother liquor.Carry out concentration dilution during application as required, also can be when making carry out concentration proportioning between the silver-colored zinc by the needs of using.
Embodiment 2: the preparation of high concentration argentiferous, zinc compound disinfectant mother liquor.
With silver peroxide 500 grams, put into reaction pot, add 100 kilograms of deionized waters, be mixed with silver-containing solution; Stir silver-containing solution after 100 minutes, add citric acid 4000 grams, the pH value of regulating silver-containing solution is 2; Continue stirring then 2 hours, is 1000 milliliters of 20% hydrogen peroxide when the pH value stabilization dropwise adds concentration 2 the time again, stirs 30 minutes again; Add this moment contain the zinc acetates that zinc ion is 2200 grams (zinc nitrate that is added is chloride ion-containing not, can not contain other can with the anion of silver ion generation chemical reaction), stirred again 30 minutes, promptly be mixed with high concentration compound disinfectant mother liquor.The weight of contained silver ion accounts for 0.4% of mother liquor weight in the compound disinfectant mother liquor, and the weight of contained zinc ion accounts for 2% of mother liquor weight in the compound disinfectant mother liquor.Carry out concentration dilution during application as required, also can be when making carry out concentration proportioning between the silver-colored zinc by the needs of using.
Embodiment 3: with the lotion of argentiferous, zinc composite sterilizing agent preparation control women ' s genital tract infection and superficial skin fungus infection.
With embodiment 1 prepared argentiferous, zinc compound bactericide, press formulation and become lotion, be applied to prevent and treat women ' s genital tract infection and superficial skin fungus and infect.
The lotion prescription is as follows:
Silver zinc compound disinfectant mother liquor (weight that contains silver ion accounts for 0.4% of mother liquor weight, the weight that contains zinc ion account for mother liquor weight 2%) 100ml
Glycerine 10ml
Propane diols 10ml
Peppermint oil 10ml
Adding distil water is to the total amount 1000ml that fills a prescription
Prepare lotion according to a conventional method, specification 100ml/ bottle, concentration 0.2mg/L) application method: directly use with lotion or with 10～20 times of afterflush of lotion dilution or scouring.Use up and wipe away dry skin with paper handkerchief and get final product, need not water and clean.
Embodiment 4: with the gel of argentiferous, zinc composite sterilizing agent preparation control women ' s genital tract infection.
Use argentiferous, zinc compound bactericide, press formulation and become gel, be applied to prevent and treat women ' s genital tract infection by embodiment 1 preparation.
The gel prescription is as follows:
Silver zinc compound disinfectant mother liquor (weight that contains silver ion accounts for 0.4% of mother liquor weight, the weight that contains zinc ion account for mother liquor weight 2%) 100.0ml
Polyethylene glycol 55.0g
Carbopol 941 40.0g
Methyl hydroxybenzoate 1.0g
Adding distil water is to the total amount 1000.0g that fills a prescription
Prepare gel according to conventional method, in the special delivery device of packing into then, specification: 10g/ props up or 3g/ props up.
Using method: before sleeping every night, the delivery device that is loaded with the antibacterial gel agent medicine is inserted the vagina deep gently, with push rod the antibacterial gel agent medicine is pushed and get final product.1 every night, 3 ~ 6 days is a course of treatment.The treatment vaginitis: 1 course of treatment, weight person takes the circumstances into consideration to increase the course of treatment; The treatment cervicitis: 1 ~ 2 course of treatment, weight person takes the circumstances into consideration to increase the course of treatment.
The gel of present embodiment preparation, through clinical treatment woman vagina infection experiment, the result is shown in table 4,5:
Table 4: gel is treated colpitic clinical trial effect
| Classification | Candidal vaginitis | Trichomonas vaginitis | Bacterial vaginosis BV | Add up to | |
| The example number | 13 | 4 | 7 | 24 | |
| Recovery from illness | The example number | 10 | 3 | 6 | 19 |
| ％ | 76.9 | 75.0 | 85.7 | 79.2 | |
| Produce effects | The example number | 1 | 1 | 1 | 3 |
| ％ | 7.6 | 25.0 | 14.3 | 12.5 | |
| Improve | The example number | 1 | 0 | 0 | 1 |
| ％ | 7.6 | 0 | 0 | 4.2 | |
| Invalid | The example number | 1 | 0 | 0 | 1 |
| ％ | 7.6 | 0 | 0 | 4.2 | |
| Total effective rate (%) | 84.6 | 100.0 | 100.0 | 91.7 | |
Table 5: the clinical trial effect of gel treatment cervicitis
| Classification | The example number | Cure | Produce effects | Invalid | Total effective rate (%) | |||
| The example number | ％ | The example number | ％ | The example number | ％ | |||
| Slightly | 8 | 6 | 75.0 | 2 | 25.0 | 0 | 0 | 100.0 |
| Moderate | 7 | 3 | 42.9 | 2 | 28.6 | 2 | 28.6 | 71.4 |
| Severe | 1 | 0 | 0 | 1 | 100.0 | 0 | 0 | 100.0 |
| Add up to | 16 | 9 | 56.3 | 5 | 31.3 | 2 | 12.5 | 87.5 |
In the clinical trial process, there is not patient any bad reaction to occur.
Embodiment 5: the preparation of argentiferous zinc composite antibiosis fabric.
10 kilograms of the argentiferous zinc compound bactericides that embodiment 2 is prepared are poured in the liquid bath, nonwoven are kept flat in the argentiferous zinc compound bactericide in the liquid bath again, soak 30 minutes, soak the back and take out and dry in the shade or dry, and sterilize then, pack.Made argentiferous zinc composite antibiosis fabric is used for medical dressing, can promote the healing of various burn wounds, surgery damage wound, surgical wound, chronic surface ulcers etc., it is antibiotic etc. also to can be used for paper diaper, women's protection pad, sanitary napkin, adult-incontinence articles.
Embodiment 6: the preparation of argentiferous zinc composite inorganic anti-biotic material.
In 10 kilograms of the prepared argentiferous zinc compound bactericides of embodiment 1, add 10 times of distilled water dilutings, put into reactor then; Again 5 kilograms are pulverized, cross 20 mesh sieves through the calcium carbonate of overactivation, add then in the reactor, stirred 2 hours, placed then 6 hours, filter, dry under less than 80 ℃ of conditions, porphyrize then, 80 mesh sieves, promptly get argentiferous zinc composite inorganic anti-biotic material.This anti-biotic material can be applicable to kind fields such as cosmetics of everyday use, plastics, coating, pottery be many.
Embodiment 7: the preparation of argentiferous zinc composite inorganic anti-biotic material
In 10 kilograms of the prepared argentiferous zinc compound bactericides of embodiment 2, add 10 times of distilled water dilutings, put into reactor then; 5 kilograms add in the reactor through the SiO 2 powders of overactivation again, stir 3 hours, place then 10 hours, filter, dry under less than 80 ℃ of conditions, porphyrize then, and mistake 100 mesh sieves promptly get argentiferous zinc composite inorganic anti-biotic material.This anti-biotic material can be applicable to kind fields such as cosmetics of everyday use, plastics, coating, pottery be many.
Embodiment 8: the preparation of argentiferous zinc compound bactericide toothpaste.
Argentiferous zinc composite inorganic anti-biotic material with embodiment 6 and 7 preparations prepares antiseptic toothpaste as the rubbing agent in the toothpaste component.
The percentage by weight composition of present embodiment antiseptic toothpaste is composed as follows:
Composition weight %
The argentiferous zinc compound bactericide 46.0 that contains silica composition
Sodium carboxymethylcellulose 2.7
Xanthans 3.0
Glycerine 5.0
Peppermint oil 1.4
Tetrasodium pyrophosphate 0.5
The sorbitol solution 10.0 of concentration 70%
Titanium dioxide 0.8
Sorbierite saccharic acid 0.6
Deionized water 30.0
With the conventional method of above-mentioned each composition, make argentiferous zinc antibacterial agent toothpaste with preparation toothpaste.
For the people who is suitable for different taste uses, present embodiment can be selected different flavourings, makes the antiseptic toothpaste of different flavor.
Embodiment 9: the preparation of the antibiotic collutory of argentiferous zinc (Jieyanshuang oral liquor).
The percentage by weight composition of the antibiotic collutory of argentiferous zinc (Jieyanshuang oral liquor) is composed as follows:
Composition weight %
Argentiferous zinc compound disinfectant (Ag
4+: Zn 0.4%,
2+: 0.2%) 10
Glycerine 3
Peppermint oil 1
Caryophyllus oil 1
Soil temperature-60 5
Green pigment (water-soluble) 1
Deionized water 79
Peppermint oil, caryophyllus oil are dissolved in the soil temperature-60, add glycerine and stir, argentiferous zinc compound disinfectant is added stir again, add appropriate amount of deionized water at last and stir, place the collutory (Jieyanshuang oral liquor) that promptly gets argentiferous zinc antibacterial agent after 1 hour.
Embodiment 10: the preparation of argentiferous zinc antimicrobial gums.
The percentage by weight composition of argentiferous zinc antimicrobial gums is composed as follows:
Composition weight %
Argentiferous zinc compound disinfectant (Ag
4+: Zn 0.4%,
2+: 0.2%) 5.0
Matrix 25.0
Concentration is 70% sorbitol solution 10.0
Isosorbide dimethyl ether 10.0
Glycerine 1.5
Crystalline sorbitol 47.0
Peppermint oil 1.5
In the blender of water-bath heating, under 37 ℃ ~ 39 ℃, mix matrix, mix and add argentiferous zinc compound disinfectant and flavouring after 5 minutes, continue again to mix after 2 minutes temperature is elevated to 45 ℃, on a flat board, it is processed then and cast strip, promptly get the silver-containing antibacterial agent chewing gum.
Embodiment 11: the preparation of the antibiotic collyrium of argentiferous zinc.
Composition weight %
Silver zinc compound disinfectant (Ag
4+: Zn 0.04%,
2+: 0.02%) 10.0
Vitamin B6 0.2
Taurine 0.1
Aminocaproic acid 0.5
Sodium Hyaluronate 0.2
Distilled water 89.0
Earlier with 50 ml distilled waters with vitamin B6, taurine, aminocaproic acid, Sodium Hyaluronate dissolving, slowly add argentiferous zinc compound disinfectant again, last adding distil water to 100 milliliter stirs, filtration, packing gets final product.
Embodiment 12: the preparation of the antibiotic contact lenses conditioning liquid of argentiferous zinc.
Composition weight %
Argentiferous zinc compound disinfectant (Ag
4+: Zn 0.4%,
2+: 0.2%) 5
Distilled water 95
With 95 ml distilled waters, join in 5 milliliters the argentiferous zinc compound disinfectant, the limit edged stirs, and filters, and packing gets final product.
Claims (15)
1, a kind of argentiferous, zinc composite sterilizing agent prepare by the following method: the oxide of silver is mixed with silver-containing solution, regulates pH value to 1～5; In silver-containing solution, add hydrogen peroxide, be mixed with the aqueous solution that contains the high price silver ion; Soluble zinc salt is joined in the aqueous solution that contains the high price silver ion again, promptly become the composite sterilizing agent of argentiferous, zinc, the ratio of weight and number of described zinc ion and silver ion is a silver ion: zinc ion=1: 1～100.
2, a kind of method for preparing argentiferous, zinc composite sterilizing agent may further comprise the steps: 1. with the oxide and the oxide of deionized water according to silver of silver: the ratio of weight and number of deionized water=1: 200 mixes, and is mixed with silver-containing solution; 2. after stirring silver-containing solution 15 minutes～2 hours, regulate pH value to 1～5 of silver-containing solution; 3. be 1～30% hydrogen peroxide with concentration according to the oxide of ratio of weight and number for silver: hydrogen peroxide=1: 1～100 join in the silver-containing solution, are mixed with to contain the argentic aqueous solution; 4. according to silver ion: the soluble zinc salt of the ratio of weight and number of zinc ion=1: 1～100 joins and contains in the argentic aqueous solution, obtains the composite sterilizing agent of argentiferous, zinc.
3, preparation method as claimed in claim 2 is characterized in that: the oxide of described silver is silver peroxide or silver oxide.
4, as claim 2 or 3 described preparation methods, it is characterized in that: the material of described adjust pH is selected from perchloric acid, sulfuric acid, nitric acid, citric acid, acetate, acetic acid, malic acid, lactic acid or carbonic acid.
5, as claim 2 or 3 described preparation methods, it is characterized in that: described soluble zinc salt is selected from zinc sulphate, zinc nitrate, zinc acetate, zinc lactate, zinc gluconate, ethylenediamine tetra-acetic acid zinc, zinc malate or zinc citrate.
6, argentiferous, the application of zinc composite sterilizing agent in the preparation dental care products.
7, application as claimed in claim 6 is characterized in that: described dental care products comprise toothpaste, collutory, oral spray, tooth powder, tooth gel and chewing gum.
8, argentiferous, the application of zinc composite sterilizing agent in the medicine of preparation control women ' s genital tract infection, superficial skin fungus infection and skin trauma.
9, application as claimed in claim 8 is characterized in that: the formulation of described medicine is lotion, spray, foaming agent, gel, creme, paste, emulsion, suppository, film, effervescent tablet and fast disintegrating tablet.
10, use as claimed in claim 8 or 9, it is characterized in that: described women ' s genital tract infection comprises monilial vaginitis, senile vahinitis, bacterial vaginosis BV, trichomonas vaginitis, Combination vaginitis, wound healing after chronic cervicitis, the cervical erosion physical treatment, mycoplasma choamydiae infection, gonococcal infection; Described superficial skin fungus infects and comprises acne, acne, whelk, ringworm of the body, the ringworm of the foot, the tinea manuum, favus of the scalp, jock itch, trichophytosis, onychomycosis and vinasse nose; Described skin trauma comprises burn and scald wound, surgery damage wound, surgical wound and chronic surface ulcers.
11, argentiferous, the application of zinc composite sterilizing agent in the preparation anti-biotic material.
12, application as claimed in claim 11 is characterized in that: described anti-biotic material comprises that with yarn fabric or nonwoven or inorganic mineral be that the inoganic solids anti-biotic material of carrier, organic solid anti-biotic material and the plastics that organic material is carrier are the antibiotic plastic of carrier.
13, application as claimed in claim 12 is characterized in that: described inorganic mineral is selected from one or more in calcium carbonate, zeolite, silica, calcium phosphate, calcium dihydrogen phosphate, apatite, hydroxyapatite, fluor-apatite, white carbon black, calcium phosphate dibasic dihydrate, hydration silica, calcium pyrophosphate, tricalcium phosphate, sepiolite, active carbon, basic zirconium phosphate, titanium dioxide, kaolin, bentonite, chalky soil, calcium lactate, calcium citrate, calcium gluconae, montmorillonite or the graphite.
14, argentiferous, the application of zinc composite sterilizing agent in preparation collyrium, hand cleanser, family expenses cleaning agent and contact lenses conditioning liquid.
15, argentiferous, the application of zinc composite sterilizing agent in preparation medicine equipment, sterilizing article, amenities and cosmetics.
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| CN112811540A (en) * | 2021-01-04 | 2021-05-18 | 奉节县体育发展中心 | Swimming pool disinfection method |
| CN112868665A (en) * | 2021-01-13 | 2021-06-01 | 东莞市八谷生物技术有限公司 | Disinfectant containing supermolecule silver and preparation method thereof |
| CN112868665B (en) * | 2021-01-13 | 2022-03-15 | 东莞市八谷生物技术有限公司 | Disinfectant containing supermolecule silver and preparation method thereof |
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| CN116548434A (en) * | 2022-01-28 | 2023-08-08 | 南京银宽医药技术有限公司 | High-valence silver-loaded zeolite antibacterial liquid and preparation method thereof |
| CN114713814A (en) * | 2022-05-27 | 2022-07-08 | 苏州工业园区安泽汶环保技术有限公司 | Preparation method of core-shell structure carbon-coated silver-zinc nano microsphere antibacterial material |
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