CN1743027A - Silver-contained oral-cavity cleaning article - Google Patents
Silver-contained oral-cavity cleaning article Download PDFInfo
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- CN1743027A CN1743027A CN 200410073659 CN200410073659A CN1743027A CN 1743027 A CN1743027 A CN 1743027A CN 200410073659 CN200410073659 CN 200410073659 CN 200410073659 A CN200410073659 A CN 200410073659A CN 1743027 A CN1743027 A CN 1743027A
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Abstract
The silver-contained mouth cavity cleaning article can be toothpaste, gargle, clean-flavouring liquor, mouth cavity spray, tooth powder, tooth gel and chewing gum containing silver-contained bactericide H4Ag2O6. Its composition includes silver-contained bactericide H4Ag2O6 and medicine additive. The medicine additive can be selected from deionized water or distilled water, surfactant, abrasive, desensitizing agent, apocrustic astringent, anticarious agent, thickener, moisture-retaining agent, odorizer, corrective, sweetening agent and coloring agent. Its bactericidal rate can be up to above 97.0%.
Description
Technical field
The present invention relates to dental care products, particularly relate to silver-contained oral-cavity cleaning article with sterilization nursing role.
Background technology
Periodontal disease is a kind of chronic, the destructive disease of carrying out property that occurs in tooth supporting tissues such as gingiva, periodontal membrane and alveolar bone, can have influence on most teeth even whole mouthful of tooth.How asymptomatic this disease is in early days, late period can occur pathological changes such as odontoseisis, periodontal pyorrhea, periodontal abscess, causes defect of dentition or dentition defect, makes organ of mastication lose integrity and destroy its function.In addition, it can also become infection focus, causes the pathological changes of other organs, influences whole body health.Periodontal disease comprises periodontitis, Occlusal Trauma, periodontosis and periodontal atrophy.In, periodontitis very more among the old people sees, and, suffer from this sick number and its order of severity and also increase gradually along with the increasing of age.
Periodontal not only brings harm to people's health, and people's work, social activity, life brought seriously influences, for example: halitosis, its pathogenic factor is very complicated, but great majority are caused by oral cavity bacterium.
In the prior art, have the dental care products of sterilization nursing role, adopt the product of chemobiotic or Chinese medicine ingredients more, still, because their drug resistance and toxic and side effects make that its application prospect is troubling.
Silver have microbe killing properties can, but silver under metallic state, itself can not sterilize, only just have anti-microbial property at the silver ion state, and do not produce drug resistance, its antibiotic mechanism is: 1, silver and sulfydryl in the pathogenic bacterium metabolic enzyme combine, and make enzyme deactivation, cause pathogenic bacterium not energy metabolism and death; 2, the Peptidoglycan reaction that exposes on silver and the bacteria cell wall forms the reversibility complex, makes it not advance cell to oxygen transport, stops the pathogenic bacteria activity, causes its death; 3, the DNA base combination in silver ion and the pathogenic bacterium, silver ion forms cross-linked each other, causes the dna structure degeneration, suppresses it and duplicates, and makes the pathogenic bacterium inactivation.
In the prior art, have argent is applied in the dental care products, disclosedly as Chinese patent 03118529.0 be: nano colloidal silver toothpaste, it is that argent is made electrode, prepare collargol by the electric spark bombardment then, and then mix in the toothpaste, the shortcoming of this technology is that the concentration of silver ion is low, rate of release is slow, can not play germ-resistant effect at short notice.
The present patent application people holds Patent right Chinese patent ZL97108681.8, discloses a kind of preparation method of bactericide containing silver, and this bactericide containing silver is the argentiferous hydrate, and molecular formula is expressed as H
4Ag
2O
6, the silver in this argentiferous hydrate exists with ionic condition, and the concentration of silver ion is higher.
Summary of the invention
The purpose of this invention is to provide a kind of silver-contained oral-cavity cleaning article with sterilization nursing role.
For achieving the above object, the present invention takes following technical scheme: a kind of silver-contained oral-cavity cleaning article, its composition comprises bactericide containing silver H
4Ag
2O
6With human body acceptable drug additive.
In the described silver-contained oral-cavity cleaning article, the content of silver ion is 1～4000 * 10
-4%mg/L.
Described medicated premix is selected from deionized water or distilled water, surfactant, abrasivus, desensitizer, astringent, anti-caries agent, thickening agent, wetting agent, correctives, sweeting agent and coloring agent.
Described surfactant is selected from the ethanolamine salt of glycerine monofatty ester, sulfate mono salt, dodecyl benzene sulfonate class, aliphatic amide compounds or fatty acid.
Described abrasivus is selected from hydration Silicon stone, calcium carbonate, calcium pyrophosphate, dalcium biphosphate, tricalcium phosphate, silicon dioxide, hydroxyapatite, fluor-apatite, calcium phosphate, white carbon black or calcium phosphate dibasic dihydrate.
Described desensitizer is selected from potassium nitrate or sodium citrate.
Described astringent is selected from zinc citrate, sodium citrate or zinc lactate.
Described anti-caries agent is selected from erythritol, pyrophosphoric acid two alkali metal salts, pyrophosphoric acid four alkali metal salts, and their mixture.
Described thickening agent is selected from sodium carboxymethyl cellulose, hypromellose, hydroxyethyl-cellulose, hydroxy methocel, paragutta, polyvinylpyrrolidone or xanthan gum.
Described wetting agent is selected from propylene glycol, glycerol, urea element, sorbitol, xylitol or Polyethylene Glycol.
Described correctives is selected from Oleum Menthae Rotundifoliae, Oleum menthae, wintergreen oil, Oleum Caryophylli, returns celery oil, orange-seed oil, Oleum Cinnamomi, cattle root of Dahurian angelica oil or Fructus Citri Limoniae oil.
It is sweet that described sweeting agent is selected from sugar, lactose, maltose, maltose alcohol, A Sibagan, Pyrusussuriensis saccharic acid, acesulfame-K, xylitol or manna.
Described coloring agent is selected from aluminium oxide, hydrated alumina, zirconium oxide or titanium dioxide.
Described silver-contained oral-cavity cleaning article comprises and contains bactericide containing silver H
4Ag
2O
6The toothpaste of composition, collutory (Jieyanshuang oral liquor), oral spray, dentifrice, tooth gel and chewing gum.
The percentage by weight of described toothpaste, tooth gel or dentifrice composition comprises in forming: H
4Ag
2O
6Solution 0.1～20%, abrasivus 5～56%, surfactant 0.5～10%, thickening agent 0.1～5%, wetting agent 1～25%, correctives 0.02～2%, coloring agent 0.01～0.8%, sweeting agent 0.1～3%, deionized water 1～30%; The percentage by weight of described toothpaste or tooth gel composition also comprises one or more desensitizeies 0.1～2%, anti-caries agent 0.01～0.5% in forming.
The percentage by weight of described collutory (Jieyanshuang oral liquor) or oral spray composition comprises in forming: H
4Ag
2O
6Solution 0.1～40%, deionized water 50～99%, wetting agent 0.01～45%, surfactant 0.01～5%, correctives 0.02～3%, sweeting agent 0.1～2%, coloring agent 0.01～0.3%, desensitizer 0.1～2%, anti-caries agent 0.01～0.4%.
The percentage by weight of described chewing gum component comprises in forming: H
4Ag
2O
6Solution 0.1～20%, gum base 25～99%, correctives 0.1～3% and sweeting agent 0.1～10%.
The present invention is with bactericide containing silver H
4Ag
2O
6Therefore advantages such as the silver-contained oral-cavity cleaning article for the effective ingredient preparation has the concentration of silver ions height, does not contain nitrate anion, and anti-microbial property is strong, contain bactericide containing silver H
4Ag
2O
6The silver-contained oral-cavity cleaning article of composition comprises toothpaste, collutory (Jieyanshuang oral liquor), oral spray, dentifrice, tooth gel and chewing gum etc., and prevention oral disease and cleaning oral cavity are had a significant effect.Test shows that dental care products of the present invention can reach more than 97.0% the average bactericidal rate of oral cavity pathogen, and it is low to have a bacteriocidal concentration, the fast characteristics that sterilize, and contrast test shows that its average bactericidal rate is higher than the collargol tooth paste product.
The specific embodiment
Below by example in detail particular content of the present invention.
Embodiment 1: the preparation of antibiotic dental caries toothpaste.
The percentage by weight of antibiotic dental caries toothpaste component is composed as follows:
Composition weight %
H
4Ag
2O
6Solution (concentration 4000 * 10
-4%mg/L) 10.0
Calcium phosphate 48.0
Hydroxyapatite 8.0
Sodium carboxymethyl cellulose 1.7
Xanthan gum 3.0
Glycerol 5.0
Oleum menthae 1.4
Tetrasodium pyrophosphate 0.5
70% sorbitol solution 10.0
Titanium dioxide 0.8
Sorbitol saccharic acid 0.6
Deionized water 11.0
With the conventional method of mentioned component, make silver-containing antibacterial dental caries toothpaste with preparation toothpaste.
For the people who is suitable for different taste uses, abrasivus in this toothpaste component and correctives can be selected in technical scheme provided by the present invention, can be made into the antiseptic toothpaste of different flavor.
Embodiment 2: the preparation of antibiotic antiallergic toothpaste.
The percentage by weight of antibiotic antiallergic toothpaste component is composed as follows:
Composition weight %
H
4Ag
2O
6Solution (concentration 4000 * 10
-4%mg/L) 10.0
Calcium phosphate 48.0
Hydroxyapatite 8.0
Sodium carboxymethyl cellulose 1.7
Xanthan gum 3.0
Glycerol 5.0
Oleum menthae 1.4
Sodium citrate 0.5
70% sorbitol solution 10.0
Titanium dioxide 0.8
Sorbitol saccharic acid 0.6
Deionized water 11.0
With the conventional method of mentioned component, make silver-containing antibacterial antiallergic toothpaste with preparation toothpaste.
For the people who is suitable for different taste uses, abrasivus in this toothpaste component and correctives can be selected in technical scheme provided by the present invention, can be made into the antiseptic toothpaste of different flavor.
Embodiment 3: the preparation of the transparent antibacterial gel toothpaste of argentiferous.
The percentage by weight of the transparent antibacterial gel toothpaste component of argentiferous is composed as follows:
Composition weight %
H
4Ag
2O
6Solution (concentration 2000 * 10
-4%mg/L) 10.0
Sodium carboxymethyl cellulose 2.4
Glycerol 3.0
70% sorbitol solution 20.0
Dalcium biphosphate 25.0
Tricalcium phosphate 15.0
Oleum menthae 1.4
Deionized water 23.2
With the conventional method of mentioned component, make the transparent antibacterial gel toothpaste of argentiferous with preparation toothpaste.
For the people who is suitable for different taste uses, abrasivus in this toothpaste component and correctives can be selected in technical scheme provided by the present invention, can be made into the antiseptic toothpaste of different flavor.
Embodiment 4:
In the made toothpaste of embodiment 1,2 and 3, add zinc lactate or zinc citrate, play the healing effect that strengthens anti-microbial property and promote periodontal.
Embodiment 5: the preparation of silver-containing antibacterial collutory (Jieyanshuang oral liquor).
The percentage by weight of silver-containing antibacterial collutory (Jieyanshuang oral liquor) composition is composed as follows:
Composition weight %
H
4Ag
2O
6Solution (concentration 2000 * 10
-4%mg/L) 10
Glycerol 3
Oleum menthae 1
Oleum Caryophylli 1
Soil temperature-60 5
Green pigment (water solublity) 1
Deionized water 79
Oleum menthae, Oleum Caryophylli are dissolved in the soil temperature-60, add glycerol and stir, again with H
4Ag
2O
6Solution (concentration 2000 * 10
-4%mg/L) add stirring, add appropriate amount of deionized water at last and stir, place and promptly got silver-containing antibacterial collutory (Jieyanshuang oral liquor) in 1 hour.
Embodiment 6: the preparation of silver-containing antibacterial oral spray.
According to the preparation method of embodiment 5,, canned in having manually or in the container of gas valve shower nozzle, promptly making the silver-containing antibacterial oral spray with the solution that makes.
Embodiment 7: the preparation of silver-containing antibacterial chewing gum.
The percentage by weight of silver-containing antibacterial chewing gum component is composed as follows:
Composition weight %
H
4Ag
2O
6Solution (concentration 4000 * 10
-4%mg/L) 5.0
Gum base 25.0
70% sorbitol solution 10.0
Isosorbide dimethyl ether 10.0
Glycerol 1.5
Crystalline sorbitol 47.0
Oleum menthae 1.5
In the blender of heating in water bath, under 37～39 ℃, mix gum base, mix and add H after 5 minutes
4Ag
2O
6Solution, correctives continue to mix after 2 minutes that temperature is elevated to 45 ℃ again, on a flat board it are processed then and cast strip, promptly get the silver-containing antibacterial chewing gum.
Embodiment 8: contain H
4Ag
2O
6Solution toothpaste and collargol toothpaste are to the antibacterial activity comparative test of oral cavity pathogen.
To contain H
4Ag
2O
6Solution toothpaste is test drug, and collargol toothpaste is reference substance, and test strain comprises: Streptococcus mutans ATCC6715, lactobacillus ATCC4356, actinomyces viscosus ATCC19246, escherichia coli ATCC25922, staphylococcus aureus ATCC25923, Candida albicans ATCC76615.
Test data is as shown in table 1.Result of the test shows: contain H
4Ag
2O
6The toothpaste of solution has very strong lethal effect to Streptococcus mutans, lactobacillus, actinomyces viscosus, escherichia coli, staphylococcus aureus, Candida albicans, three kinds of concentration (50 * 10
-4%mg/L, 100 * 10
-4%mg/L, 200 * 10
-4%mg/L) act on 5 minutes down, sterilizing rate can reach more than 99.0%; Three kinds of concentration (50 * 10
-4%mg/L, 100 * 10
-4%mg/L, 200 * 10
-4%mg/L) act on 1 minute down, average bactericidal rate can reach more than 97.0%.And reference substance collargol toothpaste is 77.99% to 1 minute average bactericidal rate of six kinds of oral cavity pathogen effects.As seen that oral cavity pathogen is had a bacteriocidal concentration is low in the present invention, and fast characteristics sterilize.
Table 1: test data
| Test strain | Sample concentration * 10 -4％mg/L | Different time (min) sterilizing rate (%) | |||
| 1 | 3 | 5 | 10 | ||
| Streptococcus mutans ATCC6715 | 200 | 99.86％ | 99.89％ | 99.97％ | 100％ |
| 100 | 97.9％ | 99.83％ | 99.97％ | 100％ | |
| 50 | 94.5％ | 99.74％ | 99.94％ | 99.94％ | |
| Contrast (100) | 80.7％ | 83.33％ | 87.37％ | 90.18％ | |
| Lactobacillus ATCC4356 | 200 | 97.33％ | 98.61％ | 99.14％ | 99.96％ |
| 100 | 95.97％ | 98.43％ | 99.23％ | 99.54％ | |
| 50 | 94.82％ | 97.18％ | 99.12％ | 99.41％ | |
| Contrast (100) | 78.10％ | 81.32％ | 86.36％ | 90.90％ | |
| Actinomyces viscosus ATCC19246 | 200 | 99.76％ | 99.84％ | 99.84％ | 100％ |
| 100 | 99.27％ | 99.66％ | 99.84％ | 99.92％ | |
| 50 | 95.3％ | 96.73％ | 99.01％ | 99.11％ | |
| Contrast (100) | 76.62％ | 82.0％ | 90.08％ | 93.71 | |
| Escherichia coli ATCC25922 | 200 | 99.76％ | 99.89％ | 99.97％ | 100％ |
| 100 | 96.9％ | 98.83％ | 99.87％ | 100％ | |
| 50 | 95.5％ | 99.64％ | 99.84％ | 99.96％ | |
| Contrast (100) | 79.7％ | 82.33％ | 86.37％ | 88.18％ | |
| Staphylococcus aureus ATCC25923 | 200 | 97.33％ | 98.61％ | 99.94％ | 99.96％ |
| 100 | 95.97％ | 96.43％ | 99.43％ | 99.54％ | |
| 50 | 93.82％ | 95.18％ | 99.32％ | 99.61％ | |
| Contrast (100) | 78.26％ | 80.32％ | 83.36％ | 86.90％ | |
| Candida albicans ATCC76615 | 200 | 99.48％ | 99.76％ | 99.86％ | 100％ |
| 100 | 99.24％ | 99.56％ | 99.86％ | 99.96％ | |
| 50 | 94.23％ | 96.73％ | 99.12％ | 99.42％ | |
| Contrast (100) | 74.60％ | 80.21％ | 87.08％ | 90.61 |
Embodiment 9: silver-containing antibacterial collutory (Jieyanshuang oral liquor) and silver-containing antibacterial oral spray are to the inhibiting clinical trial of halitosis.
With embodiment 5 and 6 silver-containing antibacterial collutory (Jieyanshuang oral liquor) and the silver-containing antibacterial oral spray products of making, be respectively applied for 20 halitosis patients.20 patients are divided into two groups, and 10 every group, one group of silver-containing antibacterial collutory (Jieyanshuang oral liquor) on probation, another group silver-containing antibacterial oral spray on probation, trial method: use silver-containing antibacterial collutory (Jieyanshuang oral liquor) to gargle every day and use three times at least, continue to have used 1 month; Use the silver-containing antibacterial oral spray, in the oral cavity, spray with spray every day and use at least three times, continue to have used 1 month.Result of the test: 11 patient's halitosis abnormal flavour are eliminated; 7 residual slight halitosis abnormal flavour of patient, 2 status of patient improve not obvious.Test shows that silver-containing antibacterial collutory of the present invention (Jieyanshuang oral liquor) and silver-containing antibacterial oral spray product have treatment and preventive effect to halitosis.
Claims (11)
1, a kind of silver-contained oral-cavity cleaning article comprises bactericide containing silver H
4Ag
2O
6With human body acceptable drug additive, the content of silver ion is 1～4000 * 10 in the described dental care products
-4%mg/L.
2, silver-contained oral-cavity cleaning article as claimed in claim 1, it is characterized in that described medicated premix is selected from least two kinds in the following substances: deionized water or distilled water, surfactant, abrasivus, desensitizer, astringent, anti-caries agent, thickening agent, wetting agent, correctives, sweeting agent and coloring agent.
3, silver-contained oral-cavity cleaning article as claimed in claim 1 or 2 is characterized in that, described medicated premix is selected from following concrete material:
Described surfactant is selected from the ethanolamine salt of glycerine monofatty ester, sulfate mono salt, dodecyl benzene sulfonate class, aliphatic amide compounds or fatty acid;
Described abrasivus is selected from hydration Silicon stone, calcium carbonate, calcium pyrophosphate, dalcium biphosphate, tricalcium phosphate, silicon dioxide, hydroxyapatite, fluor-apatite, calcium phosphate, white carbon black or calcium phosphate dibasic dihydrate;
Described desensitizer is selected from potassium nitrate or sodium citrate;
Described astringent is selected from zinc citrate, sodium citrate or zinc lactate;
Described anti-caries agent is selected from erythritol, pyrophosphoric acid two alkali metal salts, pyrophosphoric acid four alkali metal salts, and their mixture;
Described thickening agent is selected from sodium carboxymethyl cellulose, hypromellose, hydroxyethyl-cellulose, hydroxy methocel, paragutta, polyvinylpyrrolidone or xanthan gum;
Described wetting agent is selected from propylene glycol, glycerol, urea element, sorbitol, xylitol or Polyethylene Glycol;
Described correctives is selected from Oleum Menthae Rotundifoliae, Oleum menthae, wintergreen oil, Oleum Caryophylli, returns celery oil, orange-seed oil, Oleum Cinnamomi, cattle root of Dahurian angelica oil or Fructus Citri Limoniae oil;
It is sweet that described sweeting agent is selected from sugar, lactose, maltose, maltose alcohol, A Sibagan, Pyrusussuriensis saccharic acid, acesulfame-K, xylitol or manna;
Described coloring agent is selected from aluminium oxide, hydrated alumina, zirconium oxide or titanium dioxide.
4, silver-contained oral-cavity cleaning article as claimed in claim 1 is characterized in that, described silver-contained oral-cavity cleaning article is toothpaste, collutory, oral spray, dentifrice, tooth gel or chewing gum.
5, as claim 1 or 4 described silver-contained oral-cavity cleaning articles, it is characterized in that: the percentage by weight of described toothpaste, tooth gel or dentifrice composition comprises in forming: H
4Ag
2O
6Solution 0.1～20%, abrasivus 5～56%, surfactant 0.5～10%, thickening agent 0.1～5%, wetting agent 1～25%, correctives 0.02～2%, coloring agent 0.01～0.8%, sweeting agent 0.1～3%, deionized water 1～30%; The percentage by weight of described toothpaste and tooth gel composition also comprises one or more desensitizeies 0.1～2%, anti-caries agent 0.01～0.5% in forming.
6, as claim 1 or 4 described silver-contained oral-cavity cleaning articles, it is characterized in that: the percentage by weight of described collutory or oral spray composition comprises in forming: H
4Ag
2O
6Solution 0.1～40%, deionized water 50～99%, wetting agent 0.01～45%, surfactant 0.01～5%, correctives 0.02～3%, sweeting agent 0.1～2%, coloring agent 0.01～0.3%, desensitizer 0.1～2%, anti-caries agent 0.01～0.4%.
As claim 1 or 4 described silver-contained oral-cavity cleaning articles, it is characterized in that 7, the percentage by weight of described chewing gum component comprises H in forming
4Ag
2O
6Solution 0.1～20%, gum base 25～99%, correctives 0.1～3% and sweeting agent 0.1～10%.
8, as claim 1 or 4 or 5 described silver-contained oral-cavity cleaning articles, it is characterized in that: the percentage by weight of described toothpaste component consists of: concentration 4000 * 10
-4%mg/L H
4Ag
2O
6Solution 10.0%, calcium phosphate 48.0%, hydroxyapatite 8.0%, sodium carboxymethyl cellulose 1.7%, xanthan gum 3.0%, glycerol 5.0%, Oleum menthae 1.4%, tetrasodium pyrophosphate or sodium citrate 0.5%, concentration 70% sorbitol solution 10.0%, titanium dioxide 0.8%, sorbitol saccharic acid 0.6%, deionized water 11.0%.
9, as claim 1 or 4 or 5 described silver-contained oral-cavity cleaning articles, it is characterized in that: the percentage by weight of described tooth gel composition consists of: concentration 2000 * 10
-4%mg/L H
4Ag
2O
6Solution 10.0%, sodium carboxymethyl cellulose 2.4%, glycerol 3.0%, concentration 70% sorbitol solution 20.0%, dalcium biphosphate 25.0%, tricalcium phosphate 15.0%, Oleum menthae 1.4%, deionized water 23.2%.
10, as claim 1 or 4 or 6 described silver-contained oral-cavity cleaning articles, it is characterized in that: the percentage by weight of described collutory or spray composition consists of: concentration 2000 * 10
-4%mg/L H
4Ag
2O
6Solution 10%, glycerol 3%, Oleum menthae 1%, Oleum Caryophylli 1%, soil temperature-60 5%, water solublity green pigment 1%, deionized water 79%.
11, as claim 1 or 4 or 7 described silver-contained oral-cavity cleaning articles, it is characterized in that: the percentage by weight of described chewing gum component consists of: concentration 4000 * 10
-4%mg/L H
4Ag
2O
6Solution 5.0%, gum base 25.0%, concentration 70% sorbitol solution 10.0%, Isosorbide dimethyl ether 10.0%, glycerol 1.5%, crystalline sorbitol 47.0%, Oleum menthae 1.5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410073659 CN1743027A (en) | 2004-09-02 | 2004-09-02 | Silver-contained oral-cavity cleaning article |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410073659 CN1743027A (en) | 2004-09-02 | 2004-09-02 | Silver-contained oral-cavity cleaning article |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1743027A true CN1743027A (en) | 2006-03-08 |
Family
ID=36138650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410073659 Pending CN1743027A (en) | 2004-09-02 | 2004-09-02 | Silver-contained oral-cavity cleaning article |
Country Status (1)
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|---|---|
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102860973A (en) * | 2012-10-22 | 2013-01-09 | 陈永安 | Toothpaste for repairing damaged tooth |
| CN104523514A (en) * | 2014-12-18 | 2015-04-22 | 东莞市阿比亚能源科技有限公司 | Tooth washing liquid |
| CN105560080A (en) * | 2015-12-16 | 2016-05-11 | 郑州人造金刚石及制品工程技术研究中心有限公司 | Efficient whitening toothpaste containing nano carbon crystal |
| WO2016082742A1 (en) * | 2014-11-24 | 2016-06-02 | Hawley & Hazel Chemical Co. (Zhongshan) Ltd. | Anti-sensitive composition for tooth |
| CN107613948A (en) * | 2015-05-29 | 2018-01-19 | 狮王株式会社 | Composition for oral cavity |
| CN112125623A (en) * | 2020-09-01 | 2020-12-25 | 泰山石膏(涡阳)有限公司 | Imitation tartar material and manufacturing method thereof |
-
2004
- 2004-09-02 CN CN 200410073659 patent/CN1743027A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102860973A (en) * | 2012-10-22 | 2013-01-09 | 陈永安 | Toothpaste for repairing damaged tooth |
| WO2016082742A1 (en) * | 2014-11-24 | 2016-06-02 | Hawley & Hazel Chemical Co. (Zhongshan) Ltd. | Anti-sensitive composition for tooth |
| CN105686960A (en) * | 2014-11-24 | 2016-06-22 | 好来化工(中山)有限公司 | Tooth sensitivity prevention composition |
| CN105686960B (en) * | 2014-11-24 | 2018-10-02 | 好来化工(中山)有限公司 | Tooth antiallergic composition |
| CN104523514A (en) * | 2014-12-18 | 2015-04-22 | 东莞市阿比亚能源科技有限公司 | Tooth washing liquid |
| CN107613948A (en) * | 2015-05-29 | 2018-01-19 | 狮王株式会社 | Composition for oral cavity |
| CN107613948B (en) * | 2015-05-29 | 2021-02-09 | 狮王株式会社 | Oral composition |
| CN105560080A (en) * | 2015-12-16 | 2016-05-11 | 郑州人造金刚石及制品工程技术研究中心有限公司 | Efficient whitening toothpaste containing nano carbon crystal |
| CN112125623A (en) * | 2020-09-01 | 2020-12-25 | 泰山石膏(涡阳)有限公司 | Imitation tartar material and manufacturing method thereof |
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