CN107613948A - Composition for oral cavity - Google Patents
Composition for oral cavity Download PDFInfo
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- CN107613948A CN107613948A CN201680031419.0A CN201680031419A CN107613948A CN 107613948 A CN107613948 A CN 107613948A CN 201680031419 A CN201680031419 A CN 201680031419A CN 107613948 A CN107613948 A CN 107613948A
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- composition
- ester
- oral cavity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
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- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The color stain for providing a kind of condensation water-soluble polyphosphates removes the composition for oral cavity that power improves, the color stain removal effect of tooth is excellent, it is characterised in that contains：(A) condensation water-soluble polyphosphates represented by following formulas (1), Mn+2PnO3n+1... (1) wherein, in formula, M represents the integer that Na or K, n are 2 or 3；(B) is one kind or two or more in aliphatic acid and ester with the branched structure that carbon number is 8~22.
Description
Technical field
Power raising is removed the present invention relates to a kind of color stain obtained by condensation water-soluble polyphosphates, the color stain of tooth removes
The composition for oral cavity of excellent effect.
Background technology
In the past, in composition for oral cavity, when removing a kind of color stain as the colored stain of tooth, by by grinding
The chemical action of the condensed phosphate such as physical action and/or polyphosphate sodium obtained from the increment of agent, to assign whitening effect.
However, the increment that grinding agent be present causes the increase and dentine (dentine) abrasion, contracting of oral mucosa stimulation
The increment of Quadrafos causes the problem of increase that as caused by its convergence oral mucosa stimulates is such, can not reduce use
Feel and give high color stain and remove power.
In patent document 1 (PCT publications the 2012/124533rd), although by two layers of divergence type liquid oral group
In compound by the ratio set of finish amount, finish/condensed phosphoric acid or its salt in particular range, so as to obtain tar
Raising, the reduction of convergence sense of (tobacco tar), color spot greasiness removal effect, but power is removed to color stain and improvement also be present
Leeway, further, since be a large amount of composition for being added with finish, so there is also problem in terms of stability and use feeling.
[prior art literature]
[patent document]
Patent document 1：PCT publications the 2012/124533rd
Patent document 2：Japanese Patent Laid-Open 2002-20251 publications
Patent document 3：Japanese Patent Laid-Open No. Sho 59-36882 publications
Patent document 4：PCT publications the 2011/077847th
The content of the invention
[inventing problem to be solved]
Therefore, it is desirable to develop one kind in composition for oral cavity, do not reduce use feeling and strengthen the color of condensed phosphate
Stain removes the new technology of power.
The present invention is to complete in view of the foregoing, and its object is to the color stain removal effect for providing a kind of tooth is excellent
And the composition for oral cavity with good use feeling.
[means for solving problem]
After the present inventor is furtherd investigate to reach above-mentioned purpose, as a result find：By in water-soluble condensed polyphosphoric acid
The aliphatic acid with specific branched structure and/or the ester with specific branched structure are added in salt, so as to big
Width improves the color stain obtained by condensation water-soluble polyphosphates and removes power, and use feeling also becomes good in addition.
That is, in the present invention, it is selected from by the condensation water-soluble polyphosphates and (B) that are represented containing (A) by following formulas (1)
It is one kind or two or more in aliphatic acid and ester with the branched structure that carbon number is 8~22, it is hereby achieved that tooth
The color stain removal effect of tooth is especially excellent and use feeling also good composition for oral cavity,
Mn+2PnO3n+1 (1)
(wherein, in formula, M expression Na or the integer that K, n are 2 or 3.).
In this case, (B) composition be preferably chosen from it is one kind or two or more in following (B-1) compositions and (B-2) composition：
(B-1) have carbon number be 8~22 branched structure aliphatic acid,
(B-2) selected from the hydroxycarboxylic acid with the branched structure that carbon number is 8~22 on sour residue and/or alcohol residue
The ester of ester, acyl amino acid ester and fatty acid ester.
In the present invention, when (B) composition is combined in (A) composition, the color stain obtained by the chemical action of (A) composition removes power spy
It is indescribably high, use feeling can not be reduced and assign excellent color stain removal effect.
In addition, the increment independent of the grinding agent acted on physics cleaning, even if its addition is few, will also be assigned excellent
Color stain removal effect, the oral mucosa that can suppress to be brought by the increment of grinding agent accordingly stimulates, further taste and fragrance
Also it will become good, good use feeling can also be given even if to the upper parodontopathy person with inflammation, pain such as gum.
In addition, although two layers of divergence type liquid preparation in patent document 1 contain condensed phosphoric acid or its salt, in oil reservoir
Finish used in be straight-chain fatty acid ester.In addition, (the Japanese Patent Laid-Open 2002-20251 of patent document 2~4
Number publication, Japanese Patent Laid-Open No. Sho 59-36882 publications, PCT publications the 2011/077847th) although in disclose addition
There are the composition for oral cavity such as the dentifrice of the aliphatic acid with branched structure, fatty acid ester, but and be not present and polycondensation phosphoric acid
Salt and specific record, do not refer to yet color stain remove power.From it is such in the prior art, can not expect by with specific
The fatty acid or ester of branched structure is so as to which the color stain of condensation water-soluble polyphosphates removes power specifically and significantly strengthens.
Therefore, the present invention provides following composition for oral cavity.
(1) a kind of composition for oral cavity, it is characterised in that contain：
(A) by following formulas (1) represent condensation water-soluble polyphosphates and
It is (B) one kind or two or more in aliphatic acid and ester with the branched structure that carbon number is 8~22,
Mn+2PnO3n+1 (1)
(wherein, in formula, M expression Na or the integer that K, n are 2 or 3.).
(2) according to the composition for oral cavity described in (1), it is characterised in that (B) composition is：
Ester with the branched structure that carbon number is 8~22,
Or the aliphatic acid for the branched structure for carbon number being 8~22 be 8~22 with carbon number branched knot
The mixture of the ester of structure.
(3) composition for oral cavity according to (1) or (2), it is characterised in that ester is selected from sour residue and/or alcohol residue
1 kind in the upper hydroxycarboxylic acid esters with the branched structure that carbon number is 8~22, acyl amino acid ester and fatty acid ester
Or two or more.
(4) composition for oral cavity according to any one of (1)~(3), it is characterised in that (B) composition is with carbon atom
Number has the branched that carbon number is 8~22 for the aliphatic acid of 8~22 branched structure and on sour residue and alcohol residue
The mixture of the fatty acid sterols ester of structure.
(5) composition for oral cavity according to any one of (1)~(4), it is characterised in that contain 0.1~2 mass %'s
(A) composition, 0.01~1 mass % (B) composition.
(6) composition for oral cavity according to any one of (1)~(5), it is characterised in that also containing 3~20 mass %'s
(C) grinding agent.
(7) composition for oral cavity according to any one of (1)~(6), it is dentifrice.
[The effect of invention]
According to the present invention it is possible to providing a kind of color stain for making to obtain by condensation water-soluble polyphosphates removes power raising, tooth
The color stain removal effect of tooth is excellent and has the composition for oral cavity of good use feeling.In addition, according to the present invention, independent of
Grinding agent increment with physics cleaning effect, there is provided excellent color stain removal effect, do not produce and brought by substantial amounts of grinding agent
Oral mucosa stimulate the problem of, even if in gum etc. have inflammation, pain patients with periodontal disease can also give it is good
Use feeling.
Embodiment
Hereinafter, the present invention will be described in further detail.The composition for oral cavity of the present invention contains：(A) it is water-soluble condensed
Quadrafos and (B) a kind or 2 kinds in aliphatic acid and ester with the branched structure that carbon number is 8~22 with
On.
(A) condensation water-soluble polyphosphates of composition are in order at the purpose of tooth color stain removal and used, by following formulas
(1) represent：
Mn+2PnO3n+1 (1)
(wherein, in formula, M expression Na or the integer that K, n are 2 or 3.).
As the condensed phosphate represented by above-mentioned formula (1), such as sodium pyrophosphate, potassium pyrophosphate, trimerization can be included
The straight-chain Quadrafos such as sodium phosphate, PTPP, sodium tetrapolyphosphate, four PA 800Ks, sodium metaphosphate, sodium trimetaphosphate,
The cyclic polyphosphates such as three potassium metaphosphates, four sodium metaphosphates, four potassium metaphosphates, calgon, hexa metaphosphoric acid potassium, they can be with
It is used alone a kind or mixes two or more use.Among these, more preferably straight-chain Quadrafos (is particularly, the degree of polymerization 2~4
Quadrafos), particularly preferred sodium tripolyphosphate.
(A) addition of the condensed phosphate of composition is preferably 0.1~2% (quality %, following phase of total composition
Together.), more preferably 0.3~1.5%, more preferably 0.6~1.5%.When more than 0.1%, color stain can be fully obtained
Remove power.When below 2%, be not in produce the situation that oral mucosa stimulates, be more suitable for maintaining use feeling well.
(B) composition is the aliphatic acid with branched structure and/or the ester with branched structure.
As the aliphatic acid with branched structure, the aliphatic acid of the branched structure with carbon number 8~22 is used.Example
Such as, sour isodecyl, different tridecanoic acid, different myristic acid, different palmitic acid, isostearic acid etc. can be included, 1 in them can be used
Kind or two or more.Wherein, from the point of view of oral cavity tissue compatibility, more preferably carbon number more than 12, especially for
12~20 higher fatty acids, more preferably isostearic acid.
On the ester with branched structure, it is 8 to have branched carbon atoms number preferably on sour residue and/or alcohol residue
~22, preferably more than 12, the hydroxycarboxylic acid esters of more preferably 12~20 such branched structure, acyl amino acid ester,
Fatty acid ester.Wherein, there is the malate, lactate, fatty acid ester (particularly, fatty acid ester) of such branched structure
It is suitable.In addition, malate, lactate are the materials for having on alcohol residue branched structure；Fatty acid ester is fat
Any one in sour residue, alcohol residue has the material of branched structure, and in this case, branched structure can both be located at fat
On sour residue or alcohol residue, it can also be located on both.
As the species of ester, the particularly preferably sterol ester with sterol backbone, wherein, preferably phytosterin ester, cholesterine
Ester, more preferably phytosterin ester.
As the ester with branched structure, can specifically include：The two isooctadecanol apples as hydroxycarboxylic acid esters
Acid esters, octyldodecanol lactate；Two (cholesterine/octyldodecanol) N- lauroyl-L- as acyl amino acid ester
The N- acylamino acid sterols such as glutamate, two (cholesterine/behenyl alcohols/octyldodecanol) N- lauroyl-Pidolidone esters
Ester；Isooctadecanol isostearate, octyldodecanol isostearate, octyldodecanol oleic acid as fatty acid ester
Ester, cholesteryl butyrate, Cholesteryl stearate, cholesterol isostearate, phytosterol isostearate, cholesteryl hydroxy
The fatty acid sterols esters such as stearate, cholesteryl oleate, cholesterine macadimia nut oil fatty acid ester, their 1 can be used
Kind or two or more.Among these, preferred plant sterol isostearate, two isooctadecanol malates, particularly preferred plant steroid
Alcohol isostearate.
As (B) composition, from the point of view of color stain removal effect, taste, smell, it is however preferred to have branched structure
Ester, particularly preferred and the aliphatic acid with the branched structure with carbon number 8~22 and the side chain with carbon number 8~22
The ester of shape structure, further preferably and with isostearic acid and phytosterol isostearate.
As the addition of (B) composition, and it is not particularly limited, but preferably the 0.01~1% of total composition, more preferably
For 0.02~0.5%, more preferably 0.05~0.4%.When more than 0.01%, sufficient color stain can be obtained and remove effect
Fruit.When below 1%, harmful effect will not be produced to taste, smell, fragrance etc., be suitable for maintaining good use feeling.
Further, particularly, and with the branched structure with carbon number 8~22 aliphatic acid and with carbon number
In the case of the ester of 8~22 branched structure, in the range of the addition of above-mentioned (B) composition, the addition of the aliphatic acid
Amount is preferably 0.01~1.0%, more preferably 0.025~0.5%, and the addition of the ester is preferably 0.01~0.5%, more excellent
Elect 0.025~0.2% as.In addition, the addition ratio on the aliphatic acid and ester, its aliphatic acid/ester is preferred by quality ratio
For 1：5~5：1.When within the range, color stain removal effect is more excellent, and taste, smell become better in addition.
In addition, in the present invention, the content of each composition is as long as no especially advance explanation in composition for oral cavity, just with manufacture
On the basis of the inventory of each composition during composition.
Formulation/shape of composition for oral cavity of the present invention is not particularly limited, such as can be modulated to liquid (molten
Liquid, emulsion, suspension etc.), semi-solid (gel, creams, cream etc.), solid it is (tablet, particle shape agent, capsule, membrane agent, mixed
Refine thing, molten solids, waxy solid, elastic solid (Hookean body) etc.) etc. any formulation.
In addition, preparation obtained by above-mentioned modulation for example may be used as dentifrice (toothpaste, liquid dentifrice, liquid dentifrice, powdery
Dentifrice etc.), collutory, smears, adhesive preparation, in mouth freshener, food (for example, chewing gum, sheet dessert, candy, rubber
Sugared (gummi), film (film), lozenge (troche) etc.) etc. various products, but in the range of oral use, be not limited to
State, but preferred dentifrice.
In the composition for oral cavity of the present invention, in addition to above-mentioned each composition, in the effective scope for not undermining the present invention,
The various composition that can be used in composition for oral cavity can also be added.As such adding ingredient, such as in dentifrice
In the case of, grinding agent, thickener can be included, binding agent, surfactant, sweetener, preservative, spices, medicinal ingredient,
Toner, pH adjusting agent, solvent etc., can suitably it be selected according to formulation.The specific example of adding ingredient shown below, but can
The composition added in the composition for oral cavity of the present invention is not limited to these compositions.
As grinding agent, such as silicic acid anhydride, crystallinity silica, amorphism silica, silica gel, aluminium can be included
The silica such as silicate based abrasive, zeolite, calcium monohydrogen phosphate anhydride, dicalcium phosphate dihydrate, calcium pyrophosphate, carbonic acid
Calcium, sodium acid carbonate, aluminium hydroxide, aluminum oxide, magnesium carbonate, tricresyl phosphate magnesium, zirconium silicate, tricalcium phosphate, hydroxyapatite, phosphoric acid four
Calcium, synthetic resin based abrasive etc..They can be used alone or two or more is applied in combination, wherein, from oral mucosa
Stimulate, from the point of view of usability, preferably the series of calcium phosphate grinding agent such as the silica such as silicic acid anhydride based abrasive, calcium phosphate
Deng inorganic abradant, especially, more preferably using silicic acid anhydride.
The addition of grinding agent is preferably the 0~20% of total composition, more preferably 3~20%, more preferably 5
~15%.It is especially excellent to the sweeping forces of the coloring thing such as color stain when more than 3%, when excessively adding, then exist and produce
The irritating worry of oral mucosa.In addition, in collutory, the addition of grinding agent is preferably the 0~10% of total composition, more
Preferably 0~5%.
As thickener, such as D-sorbite, propane diols, butanediol, glycerine, polyethylene glycol etc. can be included, can be with
Using one kind or two or more.In the case of using thickener, its addition can be in the range of without prejudice to effect of the present invention
Provided, be generally calculated as 1~60% with total composition.
As binding agent, for example, can include pulullan polysaccharide (pullulan), gelatin (gelatin), methylcellulose,
Hydroxyethyl cellulose, hydroxypropyl cellulose, sodium carboxymethylcellulose, carrageenan (carrageenan), sodium alginate, Huang
Virgin rubber, Sodium Polyacrylate, Arabic gum (arabic gum), guar gum (guar gum), locust bean gum (locust bean
Gum), the organic binder bond such as polyvinyl alcohol, PVP, carboxy vinyl polymer, tackifying silicic acid anhydride, swelling
Inorganic binders such as native (Bentonite) etc., it can use one kind or two or more in them.Generally, using organic binder bond
When addition be calculated as 0.1~3% with total composition.The use of addition during inorganic binder is preferably 1~10%.Work as nothing
When machine binding agent is tackifying silicic acid anhydride, its addition is preferably 1~7%, and more preferably 2~6%.
As surfactant, anion surfactant, nonionic surfactant, amophoteric surface active can be added
Agent.
As anion surfactant, such as N- acyl aminos hydrochlorate, alpha-alkene sulfonate, N- acyl group sulfonic acid can be included
Salt, alkyl sulfate, the sulfate etc. of fatty acid glyceride.Among these, from the point of view of versatility, preferably N- acyl groups
Amino-acid salt, alpha-alkene sulfonate, alkyl sulfate, from the point of view of foaminess/stability in hard water, more preferably lauroyl flesh
Alpha-olefin sodium sulfonate, the NaLS that propylhomoserin sodium, the carbon number as the carbon chain length of alkyl chain are 10~16.
As nonionic surfactant, such as polyoxyethylene alkyl ether, PULLRONIC F68 block can be included
Copolymer, Crodaret, the APEO of glyceride, sucrose fatty ester, alkylolamides, glycerin fatty
Acid esters etc..Among these, from the point of view of versatility, suitably using polyoxyethylene alkyl ether, Crodaret,
Alkylolamides, sorbitan fatty ester.Polyoxyethylene alkyl ether, the carbon number of its alkyl chain is preferably 14~
30.On polyoxyethylene alkyl ether, the average addition molal quantity of its oxirane is preferably 3~30.On polyethylene glycol hydrogenated castor
Sesame oil, the average addition molal quantity of its oxirane (average addition EO) is preferably 10~100.On alkylolamides, its alkyl
The carbon chain length of chain is preferably carbon number 12~14.On sorbitan fatty ester, the carbon number of its aliphatic acid is excellent
Elect 12~18 as.On polyoxyethylene sorbitan fatty acid ester, the carbon number of its aliphatic acid is preferably 16~18.Separately
Outside, on polyoxyethylene sorbitan fatty acid ester, the average addition molal quantity of its oxirane is preferably 10~40.Separately
Outside, above-mentioned ester is different from the ester of (B) composition.
As amphoteric surfactant, such as alkyl betaine system surfactant, the work of oxidation amine system surface can be included
Property agent, imidazolinium betaine system surfactant.As the specific example of amphoteric surfactant, can include 2- alkyl-
N- carboxymethyl-N- hydroxyethyl imidazole quinoline glycine betaines and fatty acid distribution of coconut oil amido alkyl betaine, wherein, preferably coconut oil fat
Sour amido propyl betaine.
Surfactant can be used alone, or can be applied in combination with two or more.Generally, using surfactant
When addition 0~10%, particularly preferably 0.01~10% are calculated as with total composition.
As sweetener, such as saccharin sodium, stevioside (stevioside), neohesperidin dihydro can be included and look into ear
Ketone, glycyrrhizin, purple perilla rutin (Perilla rutin), to methoxycinnamic aldehyde, Talin (thaumatin), palatinose
(palatinose), maltitol, xylitol, arabite etc., can use one kind or two or more.During using sweetener,
Addition can suitably provide in the range of effect of the present invention is not damaged.
As preservative, such as sodium benzoate, methyl p-hydroxybenzoate (methylparaben) can be included, to hydroxyl
The p-hydroxybenzoates such as yl benzoic acid ethyl ester, butyl p-hydroxybenzoate, EDTA salt, benzalkonium chloride
(benzalkonium chloride) etc., it can use one kind or two or more.During using preservative, addition can not damage
Suitably provided in the range of evil effect of the present invention.
As spices, can be applied in combination：Fructus Piperis peppermint oil (peppermint oil), spearmint oil (spearmint
Oil), fennel oil, eucalyptus oil, wintergreen, cinnamon oil (cassia oil), caryophyllus oil, thyme linaloe oil, sage oil, lemon oil
(lemon oil), orange oil, peppermint oil (Ha ッ カ oil), cardamom oil, coriander oil, mandarin oil (mandarin oil), limette
Oily (lime oil), lavender oil, rosemary oil, oreodaphene (laurel oil), chamomile oil (chamomile oil), page
Caraway oil (caraway oil), marjoram oil (marjoram oil), laurel (bay oil), lemongrass oil, origanum oil
(origanum oil), pinke needle oil, bitter orange flower oil (neroli oil), attar of rose, jasmine oil, grapefruit oil (grapefruit
Oil), Oran shaddock oily (sweetie oil), grape-fruit seed oil, concrete of iris (concrete of iris), peppermint absolute oil
The natural perfume material such as (absolute peppermint), rose absolute (absolute rose), flores aurantii and these natural perfume materials
Spices after working process (front-end volatiles cutting, tails cutting, fractionation, liquid-liquid extraction, refinedization, powder perfume etc.), with
And menthol, carvol, anethole, cineole, gaultherolin, cinnamic acid, eugenol, 3-l- menthoxypropane -1,
In 2- glycol, thymol, linalool, acetic acid which (alcohol) Zhi, limonenes (limonene), menthones, menthyl acetate, N- substitution-
To terpane -3- formamides, firpene, octanal, citral, pulegone, carvacryl acetate (carvyl acetate), fennel
Aldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionic ester, (neighbour) Methyl anthranilate, aminomethyl phenyl glycidic acid
Ethyl ester, vanillic aldehyde, 11 (carbon) alkanoic acid lactones, hexanal, butanol, isoamyl alcohol, hexenol, dimethylsulphide, methyl cyclopentene
Monomer perfumes such as alcohol ketone (cyclotene), furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate, further, strawberry
Spices, apple spice, banana spices, pineapple flavors, grape flavor, mango spices, cream spices, milk spices, fruit mixing
The known spices raw material used in mediation spices such as spices, tropical fruit (tree) spices etc., composition for oral cavity, but it is not limited to reality
Apply the spices of example record.
In addition, addition is also not particularly limited, above-mentioned spices raw material preferably use 0.000001~1% in the composition,
In addition, as the tax perfume spices for having used above-mentioned spices raw material, 0.1~2% is preferably used in the composition.
As colouring agent, such as safflower red pigment, Gardenia Yellow, gardenia blue pigment, Perilla color, red yeast rice can be included
Pigment, deodorized red cabbage color, carrot pigment, Hibiscus (Hibiscus) pigment, cacao color, spirulina blue color, tamarind color
The natural pigments such as element and red No. 3, red No. 104, red No. 105, red No. 106, yellow 4, Sunset Yellow FCF, green 3,
Blueness legal pigment, riboflavin, chlorophyll copper sodium, the titanium dioxide such as No. 1 etc..When adding colouring agent, its addition is with composition
Total amount meter is preferably 0.00001~3%.
The pH (20 DEG C) of the composition for oral cavity of the present invention is usually 6~10, and preferably 6~8.As pH adjusting agent, example
Acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, butanedioic acid, paddy ammonia can such as be included
The acid such as acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, natrium hydrocitricum, sodium phosphate, sodium dihydrogen phosphate
Or alkali, buffer.When adding pH adjusting agent, its addition can suitably provide in the range of effect of the present invention is not damaged.
As solvent, such as the lower alcohol of the carbon number such as water outlet and ethanol, propyl alcohol below 3 etc. can be enumerated.Solvent leads to
Often addition is in the composition for oral cavity of liquid system.When adding water as solvent, its addition is preferably in terms of total composition
20~95%.In addition, when addition lower alcohol is as solvent, its addition is preferably 1~20% in terms of total composition.
When formulation is solid, can further be used in the range of effect of the present invention is not undermined excipient, bonding agent,
Disintegrant, coating agent, polishing material etc..
Furthermore it is also possible to added in the composition for oral cavity of the present invention beyond condensation water-soluble polyphosphates of the invention
Any active ingredient (other active ingredients).As other active ingredients, antiinflammatory, tissue activation can be included
Agent, vitamin, bactericide, astringent, fluorine etc..
[embodiment]
Hereinafter, in conjunction with the embodiments, comparative example the present invention is further illustrated, but the present invention is not limited to the embodiment.
In addition, % represents quality % in no especially explanation in advance in following examples.
[embodiment, comparative example]
The Dentrifice composition of the composition shown in table 1~4 is modulated by following methods, is filled to container (aluminium lamination pressure pipe
(laminate tube)) in, evaluated by following methods.As a result as shown in table 1~4.
＜ modulator approaches ＞
(1) water soluble ingredient mixed dissolution (mixture X) at normal temperatures is made in Purified Water.
(2) binding agent is made to disperse at normal temperatures in (mixture Y), the mixture X in stirring in propane diols, addition mixing is mixed
Compound Y, modulating mixture Z.
(3) in mixture Z, using kneader (kneader) by the water soluble ingredients such as spices, surfactant, grinding agent with
Outer composition mixes at normal temperatures, carries out the deaeration implemented by depressurizing (5.3kPa), obtains Dentrifice composition.
＜ evaluation methods ＞
(1) evaluation method of color stain removal effect
Hydroxy-apatite slabstone 1 (HOYA (strain), diameter obtained from advance surface is ground with sandblasting (sandblast)
7.0mm × 3.5mm, below, hydroxy-apatite slabstone is abbreviated as HAP plates.), in the 0.5% albumin aqueous solution, tanning solution (day
This tea (trade mark：Lao Song) (Lipton (Lipton) company manufactures, by 5 light tea bag (Brisk Tea for 50g, black tea tea bag
Bag hot water extraction)) is carried out, 12g coffee in powder form (manufacture of Nescafe (Nescafe) company) is added after cooling, uses Purified Water
It is adjusted to 1,200mL.), impregnated in order in 40 DEG C of thermostat in each solution of 0.56% ironic citrate (III) aqueous ammonium
Each 30 minutes.This, which was operated in 1 day, is repeated 8~9 times, continues to be sufficiently adhering on HAP plates (120 circulations) to color stain,
Obtain the HAP plates 2 for adhering to coloured stain.
Then, by HAP plates 2 in manually saliva (50mM KCl, 1mM CaCl2, 0.1mM MgCl2, 1mM KH2PO4, pH7.0)
In the agent solution that cleans the teeth after 3 times of dilution, after being impregnated 2.5 minutes at 37 DEG C, using plate abrading machine, in identical testing liquid
In, carry out brush and sweep processing (to use brush：Lion king (strain), the clean row brush of (Systema) toothbrush 4 of serration).Brush sweeps processing and carries out 200
It is secondary.After brush is swept, washed, the HAP plates 3 after being cleaned.
On the evaluation of color stain removal effect, each L* values of measure HAP plates 1,2,3, respectively as L*1, L*2, L*3, under
Formula calculates color stain clearance, is evaluated according to following benchmark.
L* values are measured using light splitting colour difference meter (the electric color (strain) of Japan, SE-2000).
Formula：
Color stain clearance (%)={ (L*2-L*1)-(L*3-L*1) }/(L*2-L*1)
The metewand of color stain removal effect
◎：Color stain clearance is more than 40%
○：Color stain clearance more than 30%, less than 40%
△：Color stain clearance more than 20%, less than 30%
×：Color stain clearance is less than 20%
(2) evaluation method of use feeling (oral mucosa stimulation, taste, smell)
According to following scoring benchmark, judge that Dentrifice composition is put on toothbrush, cleans mouth when in oral cavity by 10 commentators
Transmucosal stimulation, taste, smell.Being averaged for the evaluation point of 10 people is obtained, is evaluated according to following metewands.
The scoring benchmark that oral mucosa stimulates；
4 points：Stimulation is not felt in oral cavity.
3 points：Feeling in oral cavity slightly stimulates.
2 points：Stimulation is felt in oral cavity.
1 point：Feel in oral cavity stimulates very much.
The metewand that oral mucosa stimulates；
◎：Average mark is more than 3.0 points, less than 4.0 points
○：Average mark more than 2.5 points, less than 3.0 points
△：Average mark more than 1.5 points, less than 2.5 points
×：Average mark is less than 1.5 points
The scoring benchmark of taste；
4 points：Peculiar smell is not felt in oral cavity.
3 points：Peculiar smell slightly is felt in oral cavity.
2 points：Peculiar smell is felt in oral cavity.
1 point：Very big peculiar smell is felt in oral cavity.
The metewand of taste；
◎：Average mark is more than 3.5 points, less than 4.0 points
○：Average mark more than 3.0 points, less than 3.5 points
△：Average mark more than 2.0 points, less than 3.0 points
×：Average mark is less than 2.0 points
The scoring benchmark of smell；
4 points：Offending smell is not felt in oral cavity.
3 points：Offending smell is slightly felt in oral cavity.
2 points：Offending smell is felt in oral cavity.
1 point：Very offending smell is felt in oral cavity.
The metewand of smell；
◎：Average mark is more than 3.5 points, less than 4.0 points
○：Average mark more than 3.0 points, less than 3.5 points
△：Average mark more than 2.0 points, less than 3.0 points
×：Average mark is less than 2.0 points
[table 1]
[table 2]
[table 3]
[table 4]
Claims (7)
1. a kind of composition for oral cavity, it is characterised in that contain：
(A) condensation water-soluble polyphosphates represented by following formulas (1),
Mn+2PnO3n+1 (1)
In formula, M expression Na or the integer that K, n are 2 or 3；
(B) is one kind or two or more in aliphatic acid and ester with the branched structure that carbon number is 8~22.
2. composition for oral cavity according to claim 1, it is characterised in that (B) composition is：
Ester with the branched structure that carbon number is 8~22,
Or the aliphatic acid for the branched structure for carbon number being 8~22 be 8~22 with carbon number branched knot
The mixture of the ester of structure.
3. composition for oral cavity according to claim 1 or 2, it is characterised in that ester is selected from residual in sour residue and/or alcohol
There is 1 in the hydroxycarboxylic acid esters, acyl amino acid ester and fatty acid ester of the branched structure that carbon number is 8~22 on base
Kind or two or more.
4. according to composition for oral cavity according to any one of claims 1 to 3, it is characterised in that (B) composition is former with carbon
The aliphatic acid for the branched structure that subnumber is 8~22 on sour residue and alcohol residue with having the side chain that carbon number is 8~22
The mixture of the fatty acid sterols ester of shape structure.
5. according to composition for oral cavity according to any one of claims 1 to 4, it is characterised in that contain 0.1~2 mass %
(A) composition, 0.01~1 mass % (B) composition.
6. according to composition for oral cavity according to any one of claims 1 to 5, it is characterised in that also containing 3~20 mass %
(C) grinding agent.
7. according to composition for oral cavity according to any one of claims 1 to 6, it is dentifrice.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015109857 | 2015-05-29 | ||
| JP2015-109857 | 2015-05-29 | ||
| PCT/JP2016/064957 WO2016194645A1 (en) | 2015-05-29 | 2016-05-20 | Composition for use in oral cavity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107613948A true CN107613948A (en) | 2018-01-19 |
| CN107613948B CN107613948B (en) | 2021-02-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680031419.0A Active CN107613948B (en) | 2015-05-29 | 2016-05-20 | Oral composition |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP6673348B2 (en) |
| KR (1) | KR20180011062A (en) |
| CN (1) | CN107613948B (en) |
| MY (1) | MY187533A (en) |
| WO (1) | WO2016194645A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018151076A1 (en) * | 2017-02-20 | 2018-08-23 | ライオン株式会社 | Gel-like dentifrice composition and stickiness inhibitor for same |
| GB2568554A (en) * | 2017-11-17 | 2019-05-22 | Fourteen Five Ltd | Buccal delivery system |
| WO2019107332A1 (en) | 2017-11-30 | 2019-06-06 | ライオン株式会社 | Oral stain removing agent, oral stain formation inhibiting agent, and oral composition |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000239135A (en) * | 1999-02-18 | 2000-09-05 | Lion Corp | Oral composition |
| CN1556692A (en) * | 2001-05-15 | 2004-12-22 | Oral care compositions | |
| CN1691934A (en) * | 2002-10-31 | 2005-11-02 | 卡德伯里亚当斯美国有限责任公司 | Compositions for removing stains from dental surfaces and methods of making and using the same |
| CN1743027A (en) * | 2004-09-02 | 2006-03-08 | 深圳市清华源兴生物医药科技有限公司 | Silver-contained oral-cavity cleaning article |
| WO2012124533A1 (en) * | 2011-03-11 | 2012-09-20 | ライオン株式会社 | Liquid oral composition with two separate layers |
-
2016
- 2016-05-20 MY MYPI2017704210A patent/MY187533A/en unknown
- 2016-05-20 JP JP2017521809A patent/JP6673348B2/en active Active
- 2016-05-20 CN CN201680031419.0A patent/CN107613948B/en active Active
- 2016-05-20 KR KR1020177027236A patent/KR20180011062A/en unknown
- 2016-05-20 WO PCT/JP2016/064957 patent/WO2016194645A1/en active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000239135A (en) * | 1999-02-18 | 2000-09-05 | Lion Corp | Oral composition |
| CN1556692A (en) * | 2001-05-15 | 2004-12-22 | Oral care compositions | |
| CN1691934A (en) * | 2002-10-31 | 2005-11-02 | 卡德伯里亚当斯美国有限责任公司 | Compositions for removing stains from dental surfaces and methods of making and using the same |
| CN1743027A (en) * | 2004-09-02 | 2006-03-08 | 深圳市清华源兴生物医药科技有限公司 | Silver-contained oral-cavity cleaning article |
| WO2012124533A1 (en) * | 2011-03-11 | 2012-09-20 | ライオン株式会社 | Liquid oral composition with two separate layers |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016194645A1 (en) | 2016-12-08 |
| MY187533A (en) | 2021-09-27 |
| KR20180011062A (en) | 2018-01-31 |
| CN107613948B (en) | 2021-02-09 |
| JP6673348B2 (en) | 2020-03-25 |
| JPWO2016194645A1 (en) | 2018-03-15 |
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