CN106176306A

CN106176306A - Oral care composition and method

Info

Publication number: CN106176306A
Application number: CN201610524696.7A
Authority: CN
Inventors: 贾扬塔·拉贾亚; 阿里夫·阿里·拜格
Original assignee: Procter and Gamble Ltd
Current assignee: Procter and Gamble Ltd; Procter and Gamble Co
Priority date: 2009-08-17
Filing date: 2010-08-17
Publication date: 2016-12-07
Also published as: CA2772119C; CN102625722A; MX2012001994A; AU2010284339A1; WO2011022343A3; AU2010284339B2; BR112012003708A2; WO2011022343A2; CA2772119A1; EP2467192A2

Abstract

Favourable oral care composition can include water insoluble carrier, sweeting agent and annexing ingredient, the group of described annexing ingredient choosing freely following composition: flavoring agent, sensory agent and combinations thereof.

Description

Oral care composition and method

The application is the divisional application of the application for a patent for invention 201080035822.3 in submission on February 13rd, 2012.

Invention field

Present patent application relates to oral care composition and correlation technique thereof, and it is insoluble that described oral care composition has water Property component and there is the various combination of sweeting agent, flavoring agent and/or sensory agent.

Background of invention

In history, oral care product such as dentifrice and collutory has been used for cleaning oral cavity.Owing to these products are usual Obtained their cleaning effect by surfactant, and surfactant provides more preferably in general under water base environment Result, therefore these products generally use the water-soluble component base material as them.But for deposition, these water solublity Base material has some shortcomings.First, described water soluble binders is rinsed rapidly owing to interacting with saliva in the oral cavity Fall, it means that the time of staying of any material being deposited in these base materials is the shortest.It is therefore desirable to be able in the oral cavity Oral care composition and the method for more preferable deposition characteristics are provided.

Additionally, in order to promote using and approving of consumer, mouthfeel is an importance of oral care product.Cause This, consumer products companies is not only devoted to provide the product with beneficial effect, but also makes described product be accepted by consumer. Accordingly, it would be desirable to improve the taste combination for oral care product.

Summary of the invention

One embodiment of the invention relates to oral care composition, and described compositions is substantially carried by water-insoluble Body, sweeting agent and annexing ingredient composition, the group of described annexing ingredient choosing freely following composition: sensory agent, flavoring agent and they Combination.Described oral care composition is designed for being applied in oral cavity.

According to another embodiment, the present invention relates to oral care composition, described compositions comprises about 50% to about The water insoluble carrier of 99%, the sweeting agent of about 0.5% to about 10% and annexing ingredient, described annexing ingredient choosing freely following group The group become: sensory agent, flavoring agent and combinations thereof.Described oral care composition is designed for being applied on tooth.

In another embodiment, the present invention relates to oral care composition, described compositions substantially by vaseline, Saccharin, Oleum menthae and menthol composition.Described oral care composition is designed for being applied on tooth.

According to following disclosure, it is better understood these and other embodiment.

Detailed Description Of The Invention

Definition

" sensory agent " refers to that main efficacy results the most in the oral cavity is to confer to sensation as the term is employed herein, the warmest Sense, cooling feeling and/or the material of sensation of pricking.

" flavoring agent " refers to that main efficacy results the most in the oral cavity is to confer to the material of taste, no as the term is employed herein Including sweeting agent.

" sweeting agent " refers to that main efficacy results the most in the oral cavity is to confer to the material of sweet taste as the term is employed herein.

" water-insoluble " refers to dissolve the material of less than about 10% in water as the term is employed herein, unless the most special Explanation.

When being used in conjunction with numerical value, term " about " refers to the scope of numerical value +/-10% thereafter；So " about 10% " will Mean 9.0% to 11.0%.

Except as otherwise noted, the most all of percentage ratio and ratio are all based on the weight of total composition.

Detailed Description Of The Invention

Oral care product has different functions in oral cavity.Such as, when expectation cleaning oral cavity, consumer typically will It may be noted that toothpaste or collutory.In order to provide this cleaning beneficial effect, paste and lotion generally individually use the water solublity base of foaming Material.The foam provided in these base materials provides cleaning efficacy, and described cleaning efficacy can be with brush or active compound combined use Beneficial effect is more cleaned to provide.Other oral care product provides more Aesthetic Function, such as breath freshening.These produce Product take various forms to peppermint candy from soluble bar.The aspect that these products most of have jointly be they one As be water miscible.Owing to the component of described offer beneficial effect is dissolved by saliva in the oral cavity and/or washes away, these products Water solublity essence limits them can provide the persistent period of its beneficial effect.

It has now surprisingly been found that water insoluble carrier can be used in oral care composition to improve mouth care Component is to the delivery in oral cavity.Some in these oral care components include such as sensory agent, flavoring agent and sweeting agent.Water is insoluble The use of property carrier makes the described oral care components time of staying in the oral cavity longer, and therefore provides longer lasting useful Effect.Such as, in some cases, described water insoluble carrier can be used even one hour or quilt after the longer time in the oral cavity Find.

Water insoluble carrier

Water-msoluble ingredients is used as the carrier in the present invention.In various different embodiments, described water is insoluble Property carrier dissolving in water is less than about 10%, 8%, 5%, 4%, 3%, 2% or 1%.In one embodiment, described water The content of insoluble carrier by weight of the composition be about 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65% to about 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99% and/or Their any combination.In different embodiments, the content of described water insoluble carrier is by weight of the composition It is about 80% to about 99%, about 80% to about 95%, or about 85% to about 95%.In another embodiment, described water is not Solubleness carrier is calculated as at least about 75% by the weight of described oral care composition.In another embodiment, described water is not Solubleness carrier is water-insoluble and non-swellability in water.In other embodiments, described water insoluble carrier bag Include gel, liquid or their mixture.Described water insoluble carrier can be the group of two or more water-msoluble ingredients Close.

In one embodiment, the group of described water insoluble carrier choosing freely following composition: native paraffin, synthetic wax, all Intellectual circle, rubber, elastomer, plastics, polrvinyl chloride, nylon, polyvinyl acetate, natural oil, artificial oil, fat, silicone, hydrocarbon, Quintessence oil, caprylic/capric triglyceride, polybutene, oleic acid, stearic acid, fluorocarbon, polyurethane prepolymer, polyethylene, polyphenyl Ethylene, polypropylene and their mixture.In another embodiment, described water insoluble carrier is PDMS natural gum, or PDMS natural gum with remove solvent such as volatile isoparaffin hydrocarbons acquisition MQ resin mixture (see United States Patent (USP) 6,074, 654)。

In one embodiment, described water insoluble carrier includes native paraffin, synthetic wax or combinations thereof.Natural Wax includes such as animal, plant and mineral wax.Animal wax includes such as Cera Flava, lanoline, shellac wax, Chinese wax etc..Plant Wax includes Brazil wax, candelilla wax, bayberry, Caulis Sacchari sinensis etc., and mineral wax include fossil waxes and ceresine (my god So ceresine, ceresin, brown coal), and pertroleum wax such as paraffin, microwax etc..In one embodiment, wax herein is natural Wax, the group of described native paraffin choosing freely following composition: Cera Flava, candelilla wax, candela wax, Brazil wax, paraffin, crystallite Wax, Fischer-Tropsch wax and their mixture.

The example of natural oil includes but not limited to vegetable oil (deriving from Semen Maydis oil), soybean oil, Oleum Gossypii semen, Petiolus Trachycarpi oil, Cortex cocois radicis Oil, mineral oil, animal oil (deriving from fish oil) etc..The example of artificial oil includes but not limited to silicone oil etc..In one embodiment, Described water-msoluble ingredients includes natural oil.In another embodiment, described natural oil includes mineral oil.An enforcement In scheme, mineral oil exists with the amount of about 30% to about 50% in the composition, and in another embodiment with The amount of about 35% to about 45% exists.

The example of elastomer includes but not limited to ethylene-EP rubbers, EP rubbers, styrene-ethylene propylene-benzene second Alkene rubber and combinations thereof, and these optionally mix further with wax.

In one embodiment, described water insoluble carrier include microwax, paraffin, Cera Flava, vaseline, mineral oil, Polybutene, silicone, natural oil, artificial oil, polyethylene or combinations thereof.In another embodiment, described water-insoluble The group of carrier choosing freely following composition: polybutene, silicone, vaseline and combinations thereof.In another embodiment, Described carrier includes vaseline.In another embodiment, described carrier is substantially made up of vaseline.

When multiple specific embodiments of water insoluble carrier are listed in herein, it is contemplated that other suitable compositions is also Suitably and belong to scope of the invention.

Sensory agent

The present invention can comprise offer sensation beneficial effect, is commonly referred to as one or more components of sensory agent.Sensory agent can There is attribute of sensation, such as warming sense, sensation of pricking or cooling feeling.Suitable sensory agent include such as menthol, menthyl lactate, Folic alcohol, Camphora, clove bud oil, Eucalyptus oil, anethole, methyl salicylate, cineole, Cortex cinnamomi japonici (Ramulus Cinnamomi), 1-8 acetic acid Herba Menthae Ester, acetaminol,Alkanone, α-ionone, methylol anethole, thymol, linalool, benzaldehyde, meat known to CGA Cinnamic aldehyde glycerine acetal and their mixture.

In one embodiment, described sensory agent includes coolant.Coolant can be any in various material A kind of.These materials being included in the invention are Methanamide, menthol, ketal, glycol and their mixture.Formyl Some examples of amine coolant include such as to paramenthan carboxyamide reagent, as be known commercially as the N-ethyl of " WS-3 "- P-terpane-3-Methanamide, it is known that the WS-23 of " WS-23 " and be known as G-180 and The N-(4-Cyanomethylphenyl) supplied by Givaudan-p-menthane carbosamided.G-180 is typically in flavor oils, as stayed orchid Oleum sesami or Oleum menthae provide with 7.5% solution.The example of menthol coolant includes such as menthol；Manufactured by Takasago Be referred to as TK-10 3-1-menthoxypropane-1,2-glycol, by Haarmann and Reimer manufacture be referred to as MGA thin Lotus ketone glycerine acetal and being referred to as by Haarmann and Reimer manufactureMenthyl lactate.Institute herein The dextrorotation of these compounds and laevoisomer and their racemic mixture is included with term menthol and menthyl.

In one embodiment, described sensory agent includes coolant, the group of described coolant choosing freely following composition: thin Lotus alcohol, 3-1-menthoxypropane-1,2-glycol, menthyl lactate, N, 2,3-trimethyl-2-butanamide, N-second Base-p-terpane-3-Methanamide, N-(4-Cyanomethylphenyl)-p-menthane carbosamided and combinations thereof.Separately In one embodiment, described sensory agent includes menthol, WS-23, N-(4-cyano methyl Phenyl)-p-menthane carbosamided or combinations thereof.In one embodiment, described sensory agent includes menthol.Separately In one embodiment, described sensory agent is substantially made up of menthol.

The amount of sensory agent used is typically to depend on a kind of preference of the factors such as all types as desired and effect intensity. Based on the weight of described oral care composition, sensory agent can exist with the amount of at most about 40%.In various different enforcements In scheme, described sensory agent can with about 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9% or 10% to about 2%, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 15%, 20%, 30% or 40% or their any group The amount closed exists.In various different embodiments, described sensory agent based on the weight of described total composition with about 0.1% to About 20.0%, about 1% to about 10% or about 3% to about 6% amount exist.

Flavoring agent

The present invention can include one or more components providing flavoring agent beneficial effect.Described flavor components is selected from sky Flavoring agent that is right and that synthesize.Natural flavour mountaineous dose can include such as oil derived from plant leaf blade, flower, fruit etc..Some generations The flavoring agent of table includes such as vanilla, Salvia japonica Thunb., origanum, parsley oil, Oleum Menthae Rotundifoliae, Oleum Cinnamomi, wintergreen oil (water Poplar acid methyl ester) and Fructus Piperis peppermint oil.For fruit flavor agent that is the most artificial, natural or that synthesize herein.These bags Including such as, tangerine oil, including Fructus Citri Limoniae, orange, rubber, Fructus Vitis viniferae, Citrus aurantium Linn., Fructus Pruni and Fructus Citri grandis, and fruit essence includes Fructus Mali pumilae, Fructus Fragariae Ananssae, cherry Fructus Persicae, orange, Fructus Ananadis comosi etc.；The flavoring agent that Kidney bean and nut derive, such as coffee, cocoa, cola, Semen arachidis hypogaeae, Semen Armeniacae Amarum etc..These can For any form, including liquid, powder etc..Additionally, it may include the flavoring agent being adsorbed onto on hydrophilic matrix, as " being spray-dried " flavoring agent.In addition, it may include the flavoring agent of encapsulating.

In one embodiment, described flavoring agent selected from Herba Menthae, Ilicis Purpureae, spice, vanilla, fruit, Citrus, cocoa, Tea or combinations thereof.In one embodiment, the group of described flavor components choosing freely following composition: Mentha arvensis L. syn.M.haplocalyxBrig, stay Lan Xiang, vanilla, Cortex Cinnamomi, Ilicis Purpureae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Vitis viniferae, Fructus Mali pumilae and combinations thereof.In another embodiment, Described flavor components includes Herba Menthae, Mentha arvensis L. syn.M.haplocalyxBrig, Herba Menthae Rotundifoliae, Ilicis Purpureae or the combinations thereof of mixing.An additional reality Executing in scheme, described flavor components includes Mentha arvensis L. syn.M.haplocalyxBrig.

The amount of flavoring agent used is typically to depend on a kind of preference of the factors such as all types as desired and effect intensity. Flavoring agent can exist with the amount of at most about 40%.In different embodiments, described flavoring agent can with about 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9% or 10% to about 2%, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 15%, 20%, 30% or 40% or they any combination of amount exist.In various different embodiments In, described flavoring agent based on the weight of described total composition with about 0.1% to about 20.0%, about 1% to about 10% or about 3% to The amount of about 6% exists.

Sweeting agent

The present invention can include one or more components providing sweeting agent beneficial effect.Suitable sweeting agent includes natural With artificial sweeting agent.Described sweeting agent can be water miscible or water-insoluble.Described sweeting agent can be also strong sweet taste Agent.

Some examples of sweeting agent include dextrose, sucrose, maltose, dextrin, dry Nulomoline, mannose, xylose, Ribose, glucose, fructose, levulose, galactose, corn syrup, high-fructose corn syrup, corn-syrup solids, partial hydrolysis Starch, aspartame, saccharin, sugar alcohol such as sorbitol, xylitol, maltose alcohol, different Fructus Hordei Germinatus and the starch of hydrogenation.

Strong sweeting agent is often two peptidyls.Some examples of strong sweeting agent include monellin, Haumatoccous danielli and L-aspartyl L-phenylalanine methyl ester and solvable saccharin salt.

In one embodiment, the group of described sweeting agent choosing freely following composition: dextrose, sucrose, maltose, paste Essence, the Nulomoline without juice, mannose, xylose, ribose, glucose, fructose, levulose, galactose, corn syrup, high fructose are beautiful Rice syrup, corn-syrup solids, boiling starch, aspartame, saccharin, sugar alcohol, the starch of hydrogenation, monellin, Haumatoccous danielli, L-aspartyl L-phenylalanine methyl ester, solvable saccharin salt and their group Close.In another embodiment, the group of described sweeting agent choosing freely following composition: saccharin, sucralose, stevioside (Rebiana), xylitol, aspartame, acesulfame potassium, monoammonium glycyrrhizinate and their mixture.Another embodiment party In case, described sweeting agent includes saccharin, sucralose, stevioside or combinations thereof.In one embodiment, institute State sweeting agent and include saccharin.In another embodiment, described sweeting agent is substantially made up of saccharin.

The amount of sweeting agent changes along with selected sweeting agent type and the content of desired sweeting agent.Sweeting agent can be with The amount of at most about 20% exists.In other embodiments, based on the weight of described oral care composition, described sweeting agent energy Enough with about 0.1%, 0.15%, 0.25%, 0.5%, 0.75%, 1%, 1.25%, 1.5%, 1.75%, 2%, 2.25%, 2.5%, 2.75%, 3%, 4%, 5% or 10% to about 1%, 2%, 3%, 4%, 5%, 10% or 20%, or theirs is any The amount of combination exists.In various different embodiments, described flavoring agent based on the weight of described total composition with about 0.1% To about 10.0%, about 1% to about 5% or the amount existence of about 1.5% to about 3%.

Other component

In addition to those listed above component, described oral care composition can additionally comprise other component.This One example of a little annexing ingredients includes affinity reagent.One group of affinity reagent is organophosphorus ester.Suitable organic phosphoric acid Ester compounds has strong affinity and has enough surface combination tendencies to solve gettering thin film albumen described dental surface Matter and residue attached to it.Themselves is attached to cation by the phosphate-based of organophosphorus ester, specifically exists Tooth or the site of some other positively chargeds, on the calcium ion of the protein residue on mucomembranous surface, and therefore by institute The hydrophobic parts stating molecule anchors to described surface, thus is modified to hydrophobic.Described phosphate-based pass through electrostatic Reciprocal action, hydrogen bond or complexing provide and are bonded cation and charged surface rapidly/combine, and this causes when application Described organophosphorus ester deposits the coating being formed on handled surface rapidly.Strong bonding causes described coating more Long reservation or durability and affinity.

The example of suitable organophosphorus compounds is by an ester of general formula representation, diester or three esters, its Middle Z¹、Z²Or Z³May be the same or different, at least one is organic moiety, is preferably chosen from having 6 to 22 carbon atoms, optionally quilt One or more phosphate-based substituted straight or branched alkyl or alkenyls；The alkyl of alkoxylate or the thiazolinyl of alkoxylate.

Some preferred reagent include the alkyl or alkenyl phosphate ester of the alkoxylate represented by having structure:

Wherein R¹Represent 6 to 22 carbon atoms of straight or branched, optionally by one or more phosphate-based replacements Alkyl or alkenyl；N and m is 2 to 4 individually and respectively, and a and b is 0 to 20 individually and respectively；Z²And Z³Can be identical Or different, each represent hydrogen, alkali metal, ammonium, protonation alkylamine or protonation official can alkylamine such as alkanolamine or R¹─ (OC_nH_2n)_a(OC_mH_2m)_b-base.Preferably, R¹Be the alkyl of at least 10 carbon atoms, and a and b each less than 10 so that Keep the overall hydrophobic character of described organophosphorus ester and give the hydrophobicity degree on described surface.

In one embodiment, described affinity reagent includes one, two and trialkyl and alkyl (many) alkoxyl phosphoric acid Ester, such as 1-isobutyl-3,5-dimethylhexylphosphoric acid, Tryfac 5573, laureth-1 phosphate ester, laureth-3 Phosphate ester, laureth-9 phosphate ester, dilauryl polyoxyethylene ether-10 phosphate ester, Trilaureth-4 phosphorus Acid esters, C_12-18PEG-9 phosphate ester and salt thereof.Many can be commercially available from suppliers, and described supplier includes Croda； Rhodia；Nikkol Chemical；Sunjin；Alzo；Huntsman Chemical；Clariant and Cognis.One In individual embodiment, described affinity reagent includes monoalkyl phosphoric acid esters.

Another example of annexing ingredient includes active component.Some examples of active component include for the prevention of dental caries and The various fluoride salts of Remineralization；By using antimicrobial, such as triclosan, hexadecylpyridinium chlorideFluorination Asia Stannum, zinc citrate or quintessence oil prevention gingivitis；With by use composition, as strontium chloride, stannous fluoride or potassium nitrate control allergy Disease；It is used as the pyrophosphate of anticalculus agent；Can be used for the peroxide of bleaching and antibacterial；Can be used for corrosion protection Or allergy protection and polymer-mineral matter surfactant, such as the polymer of phosphorylation, be specifically attached on tooth is poly- Phosphate ester, or metal ion, as formed the stannous of undissolved compound, zinc or the copper depositing on tooth.These active matters Matter may be used alone or in combination use.

Another example of annexing ingredient includes adhesive component.The present invention can include the binding agent group of safe and effective amount Point, its content is typically about 1% to about 75% by weight of the composition.In other embodiments, described binding agent Component about 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40% to about 10%, 15%, 20%, 50%, 60%, 75% or their any combination of scope in.In one particular embodiment, the amount of described adhesive component is About 10.0% to about 60.0%.In another embodiment, the amount of described adhesive component is about 1% to about 15%.

In general, adhesive component is the hydrophilic particle becoming thickness when by moisture-activated, or hydrophilic liquid Body.With regard to by moisture-activated those for, moisture may be present in such as oral care composition self, and is present in use In person oral cavity.In various different embodiments, adhesive component herein is mucoadhesive, is adhered to described tooth , hydrophilic, water miscible and contact with moisture time there is swelling character or their any combination.

In one embodiment, the group of described adhesive component choosing freely following composition: glycerol, polyalkylene oxide, Pyrusussuriensis Alcohol, polyethylene glycol oxide, carbomer, polyacrylamide, polypeptide, natural gum；Synthesized polymer natural gum；AVE/MA；AVE/MA/IB； Maleic acid or anhydride and the copolymer of ethylene, styrene and/or isobutene., polyacrylic acid and/or its polyacrylate, poly-clothing health Acid, mucoadhesive polymer, water soluble hydrophilic sexual intercourse colloid, saccharide, cellulose, cellulosic resin, acrylic resin, Their derivant and their mixture.The example of this type of material includes karaya, guar gum, gelatin, Brown algae Glue, sodium alginate, Tragacanth, chitosan, acrylamide polymer, carboxypolymethylene, polyvinyl alcohol, polyamines, poly-quaternary conjunction Thing, polyvinyl pyrrolidone or its copolymer, cationic polyacrylamide polymer, the salt of AVE/MA and salt-mixture；Polymerization Acid, polymer salt and their copolymer, poly-itaconate, polyol, their derivant and mixing of theirs Compound.

In another embodiment, the group of described adhesive component choosing freely following composition: cellulose, cellulose are derivative Thing is (such as methylcellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, Semen Maydis Starch and their mixture), starch, starch derivatives, sugar, sugar derivatives, poly(ethylene oxide), Polyethylene Glycol, polyethylene Alcohol, carrageenin, alginate, karaya, xanthan gum, guar gum, gelatin, Algin, Tragacanth, chitosan, Acrylamide polymer, carboxypolymethylene, polyamines, poly-quaternary compound, polyvinyl pyrrolidone, the salt of AVE/MA, AVE/MA, The salt-mixture of AVE/MA, polymeric acid, polymer salt, polyol and their mixture.

Ratio

Additionally, it has surprisingly been found that by water insoluble carrier be delivered to the sweeting agent in oral cavity, sensory agent and/ Or the particular combination of flavoring agent and/or ratio provide the beneficial effect of consumer's highly recognition, such as freshness, clean sense, tooth Smooth sense, tooth smooth feeling and breath freshening sense.Additionally, it was also surprisingly found that when there is sweeting agent, consumer is to water The acceptability of the oral care composition of insoluble carrier base is the highest.

Therefore, although water insoluble carrier system provides some extra on the formula of system deriving from water-solubility carrier base Motility, but in described system, sweeting agent, flavoring agent and sensory agent are seemed there is special ratio ranges, in order to produce The acceptable product of consumer.Therefore, there is the compositions of the present invention of the component existed with concrete ratio disclosed herein It is believed that to not comprising disclosed herein or providing excellent flavoring agent to have with those compositionss of the component of different ratios existence Benefit effect, and therefore provide consumer more acceptable product.Owing to Consumer acceptance contributes to promoting making of described product With, this occupies an important position in successful product development.

First ratio is the weight (" R1 ") of sensory agent weight ratio flavoring agent.This ratio by sensory agent weight % divided by local flavor Agent weight % calculates.In one embodiment, this ratio is about 0 to about 4.0.In another embodiment, this ratio It is about 0.25 to about 2.0.In another embodiment, this ratio is about 1.0.

Second ratio is flavoring agent weight ratio sweeting agent weight (" R2 ") in oral care composition.In order to calculate this Ratio, by weight % of flavoring agent divided by weight % of sweeting agent.In one embodiment, this ratio is about 0 to about 20.? In another embodiment, described ratio is about 1.0 to about 4.0.In another embodiment, described ratio be about 1.5 to About 2.5.In another embodiment, described ratio is about 2.0.

Next ratio is about sensory agent weight ratio sweeting agent weight (" R3 ").This ratio with sensory agent weight % divided by Sweeting agent weight % calculates.In one embodiment, this ratio is about 0 to about 20.In another embodiment, described Ratio is about 1.0 to about 4.0.In another embodiment, described ratio is about 1.5 to about 2.5.In another embodiment In, described ratio is about 2.0.

Last ratio is sensory agent weight and flavoring agent weight ratio sweeting agent weight (" R4 ").This ratio will be by feeling Feel that weight % of agent calculates divided by weight % of sweeting agent with the weight % phase adduction sum of flavoring agent.An embodiment party In case, this ratio is about 0.4 to about 40.In various different embodiments, this ratio be about 2.0 to about 8.0, about 3.0 to About 7.0, or about 3.0 to about 5.0.In an additional embodiment, described ratio is about 4.0.

These ratios can be used to assist in limiting consumer's oral care product acceptable for water-insoluble base.Example As, R1 is about 0.25 to about 4.0 in one embodiment, and R2 is about 0.2 to about 20, and R3 is about 0.2 to about 20.Separately In one embodiment, R1 is about 0.5 to about 2.0, and R2 is about 1.0 to about 4.0, and R3 is about 1.0 to about 4.0.At another In individual embodiment, R1 is about 1.0, and R2 is about 2.0 and R3 and is about 2.0.

Oral care composition

The various combinations of water insoluble carrier, sweeting agent, flavoring agent and/or sensory agent are possible, and are considered to belong to Scope of the invention, is discussed below some concrete combinations.

In one embodiment, oral care composition comprises water insoluble carrier, sweeting agent and annexing ingredient, described Annexing ingredient is selected from sensory agent, flavoring agent or combinations thereof.In another embodiment, oral care composition is substantially Be made up of water insoluble carrier, sweeting agent and annexing ingredient, described annexing ingredient composition selected from sensory agent, flavoring agent or they Combination.The two embodiment is all designed for being administered in described oral cavity.In one embodiment, described mouth care group Compound is designed for being administered on tooth.

In another embodiment, described oral care composition comprises the water-insoluble load of at least 75% by weight Body.In another embodiment, described water insoluble carrier by the weight of described oral care composition be calculated as about 70% to About 99%.In an additional embodiment, described water insoluble carrier is calculated as by the weight of described oral care composition About 50% to about 99%.

In another embodiment, described water insoluble carrier be rubber and/or native paraffin and/or synthetic wax and/or Polrvinyl chloride and/or nylon and/or fluorocarbon and/or polyurethane prepolymer and/or polyethylene and/or polystyrene and/ Or polypropylene and/or vaseline and/or polyvinyl acetate and/or natural oil and/or artificial oil and/or fat and/or silicone And/or hydrocarbon and/or caprylic/capric triglyceride and/or oleic acid and/or stearic acid and/or their mixture.An enforcement In scheme, described water insoluble carrier include microwax and/or paraffin and/or Cera Flava and/or vaseline and/or mineral oil and/ Or polybutene and/or silicone and/or natural oil and/or artificial oil and/or polyethylene and/or combinations thereof.Real at another Execute in scheme, the group of described water insoluble carrier choosing freely following composition: polybutene and/or silicone and/or vaseline and/or it Combination.In another embodiment, described carrier includes vaseline.In another embodiment, described carrier base It is made up of vaseline on Ben.

In another embodiment, described oral care composition comprise by weight about 0.5% to about 10% sweet Taste agent.In one embodiment, described sweeting agent select free following groups form group: dextrose, fructose, corn syrup, High-fructose corn syrup, aspartame, saccharin, sugar alcohol and their mixture.In one embodiment, described sweet taste The group of agent choosing freely following composition: saccharin, sucralose, stevioside, xylitol, aspartame, acesulfame potassium, glycyrrhizic acid Single ammonium and their mixture.In another embodiment, described sweeting agent includes saccharin, sucralose, Flos Chrysanthemi Sugar or combinations thereof.

In another embodiment, described sweeting agent is less than about 25% with the weight % sum of described annexing ingredient.? In another embodiment, the weight % sum of described sweeting agent and described annexing ingredient is less than 25%.An additional reality Executing in scheme, the weight % sum of described sweeting agent and described annexing ingredient is about 8% to about 15%.

In one embodiment, described annexing ingredient includes flavoring agent.In another embodiment, described flavoring agent The group of choosing freely following composition: Mentha arvensis L. syn.M.haplocalyxBrig, Herba Menthae Rotundifoliae, vanilla, Cortex Cinnamomi, Ilicis Purpureae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Vitis viniferae, Fructus Mali pumilae and it Combination.In another embodiment, described flavor components includes the Herba Menthae of mixing, Mentha arvensis L. syn.M.haplocalyxBrig, Herba Menthae Rotundifoliae, Ilicis Purpureae Or combinations thereof.In an additional embodiment, described flavor components is substantially made up of Herba Menthae.An enforcement In scheme, flavoring agent is about 0.2 to about 20 with the ratio of sweeting agent.

In one embodiment, described annexing ingredient includes sensory agent.In one embodiment, described sensory agent bag Include coolant.In another embodiment, the group of described sensory agent choosing freely following composition: menthol, menthyl lactate, Folic alcohol, Camphora, clove bud oil, Eucalyptus oil, anethole, methyl salicylate, cineole, Cortex cinnamomi japonici (Ramulus Cinnamomi), acetic acid 1-8 Herba Menthae Ester, acetaminol,Alkanone, α-ionone, methylol anethole, thymol, linalool, benzaldehyde, cinnamic aldehyde glycerol acetonide Aldehyde and their mixture.In another embodiment, the group of described sensory agent choosing freely following composition: menthol, 3- 1-menthoxypropane-1,2-glycol, methyl lactate, N, 2,3-trimethyl-2-butanamide, N-ethyl-p-Herba Menthae Alkane-3-Methanamide, N-(4-Cyanomethylphenyl)-p-menthane carbosamided and combinations thereof.Another embodiment party In case, described sensory agent includes menthol, WS-23, N-(4-Cyanomethylphenyl)-p- Menthane carbosamided；Or combinations thereof.In an additional embodiment, sensory agent is about with the described ratio of sweeting agent 0.2 to about 20.

In another embodiment, described annexing ingredient includes the combination of flavoring agent and sensory agent.An embodiment party In case, flavoring agent is about 0.4 to about 40 by weight plus the ratio of sensory agent with sweeting agent.In another embodiment, Sensory agent is about 0.5 to about 2.0 by weight with the ratio of flavoring agent, and flavoring agent is about by weight with the ratio of sweeting agent 1.0 to about 4.0, the ratio of sensory agent and sweeting agent is about 1.0 to about 4.0 by weight, and flavoring agent plus sensory agent with The ratio of sweeting agent is about 2.0 to about 8.0 by weight.In an additional embodiment, described oral care composition Comprise flavoring agent and the sensory agent of by weight about 1% to about 10% of by weight about 1% to about 10%.

In one embodiment, described oral care composition comprises water-solubility carrier, and described carrier includes microwax And/or paraffin and/or Cera Flava and/or vaseline and/or mineral oil and/or polybutene and/or silicone and/or natural oil and/or Artificial oil and/or polyethylene；And flavoring agent, described flavoring agent include Mentha arvensis L. syn.M.haplocalyxBrig and/or Herba Menthae Rotundifoliae and/or vanilla and/or Cortex Cinnamomi and/or Ilicis Purpureae and/or Herba Menthae and/or Fructus Fragariae Ananssae and/or Fructus Vitis viniferae and/or Fructus Mali pumilae；And sweeting agent, described sweeting agent includes dextrorotation Sugar and/or fructose and/or corn syrup and/or high-fructose corn syrup and/or aspartame and/or saccharin and/or sugar alcohol；With Sensory agent, described sensory agent includes menthol and/or menthyl lactate and/or folic alcohol and/or Camphora and/or clove bud oil And/or eucalyptus oil and/or anethole and/or methyl salicylate and/or eucalyptol and/or Cortex Cinnamomi and/or acetic acid 1-8 menthyl ester And/or acetaminol and/orAlkanone and/or α-ionone and/or methylol anethole and/or thymol and/or in which Alcohol and/or benzaldehyde and/or cinnamic aldehyde glycerol acetonide；Wherein sensory agent is about 0.5 to about by weight with the ratio of flavoring agent 2.0, and/or the ratio of flavoring agent and sweeting agent is about 1.0 to about 4.0 by weight, and/or the ratio of sensory agent and sweeting agent It is about 1.0 to about 4.0 by weight, and/or flavoring agent adds that sensory agent is about 2.0 to about by weight with the ratio of sweeting agent 8.0。

In a specific embodiment, described oral care composition is by water insoluble carrier, sweeting agent and adds Component forms, the group of described annexing ingredient choosing freely following composition: sensory agent, flavoring agent and combinations thereof, wherein feels The ratio of agent and flavoring agent is about 0.5 to about 2.0 by weight, and/or the ratio of flavoring agent and sweeting agent is about by weight 1.0 to about 4.0, and/or the ratio of sensory agent and sweeting agent by weight about 1.0 to about 4.0, and/or flavoring agent is plus sense Feel that agent is about 2.0 to about 8.0 by weight with the ratio of sweeting agent.In another specific embodiment, mouth care group Compound is substantially made up of vaseline, saccharin, Oleum menthae and menthol, and sets for the application to tooth, wherein feels The ratio of agent and flavoring agent is about 0.5 to about 2.0 by weight, and/or the ratio of flavoring agent and sweeting agent is about by weight 1.0 to about 4.0, and/or the ratio of sensory agent and sweeting agent by weight about 1.0 to about 4.0, and/or flavoring agent is plus sense Feel that agent is about 2.0 to about 8.0 by weight with the ratio of sweeting agent.In another embodiment, flavoring agent adds sensory agent 0.4 to about 40 it is about by weight with the ratio of sweeting agent.In another embodiment, sensory agent is pressed with the ratio of flavoring agent Weight is calculated as about 1.0, and flavoring agent is about 2.0 by weight with the ratio of sweeting agent, and the ratio of sensory agent and sweeting agent is by weight It is calculated as about 2.0, and flavoring agent is plus the ratio by weight about 4.0 of sensory agent with sweeting agent.

In one embodiment, described compositions is lived without surfactant, grinding agent, fluoride source, therapeutic agent Property material, mucoadhesive, polybutene, silicone and/or antimicrobial reagent.In one embodiment, described mouth care Compositions is not dentifrice.In another embodiment, described oral care composition is not collutory.Another embodiment party In case, described oral care composition is not Denture adhesive.

In one embodiment, described oral care composition is by the form for liquid or gel.Described liquid or solidifying The described oral care composition of glue form can be used together with application device.Described application device can be executed with any mouth care With device, such as swab, brush, the application device etc. of top dress foam are used together.

Although discussed above is several embodiment, it is believed that based on other embodiments discussed above, such as every kind The concrete kind of component, its percentage by weight and ratio, within falling within scope of the invention.

Using method

Oral care composition can be used for and described water insoluble carrier any to oral delivery as discussed herein Compatible oral care components.Such as, at described oral care composition, oral care composition can be by including that implication is clear New agent (as flavoring agent) and be used as flavorants, or described compositions can be by including that active substance is used as active matter Matter delivery vector.

Without being bound by theory, it is further believed that owing to forming water-insoluble layer on tooth when using, therefore will to be disappeared Expense person provides beneficial effect.Therefore, described oral care composition can be used on tooth form water-insoluble barrier.Expect Some beneficial effects that this type of barrier is had include: at least partially due to antibacterial can not adhere to reduce on tooth dental caries, tooth Speckle and dental calculus, at least partially due to dentinal tubule's adhesion and reduce sensitivity, at least partially due to described coating is as right The barrier of caustic operate and reduce corrosion and prophylaxis of teeth variable color, and oral sensation impression and/or apparent always Structural reform is apt to, and described outward appearance is widely with attractive in appearance, if gloss, brilliance, shinny, smoothness, slickness and oral cavity cleaning sense are as spy Levy.

Embodiment

Embodiment 1: the various compositionss of the present invention

Following non-limiting examples illustrate and describes the embodiment of described theme invention further, is wherein mixed with Basic and optional composition.It is to be appreciated that embodiment provide purpose only for the purpose of illustration, be not interpreted as Restriction to scope, because without departing from the spirit and scope of the present invention, its many change is possible.

In order to prepare compositions B of foregoing embodiments, E, I and J, melted described wax at 95 DEG C, and at high temperature will Other component is mixed into it.In order to prepare foregoing embodiments A, C, D, F, G, H and K, vaseline and/or Versagel are heated To about 70 DEG C, and other component is at high temperature mixed into.For all embodiments, compositions is made to reach room temperature before the use.

Additionally, each in above-described embodiment formula also can be mixed with each other to provide crossbred embodiment.

Embodiment 2: ratio

In order to prepare foregoing embodiments A, B and C, vaseline is heated to about 70 DEG C, and other component is at high temperature mixed Enter.For all embodiments, compositions is made to reach room temperature before the use.After being prepared for described sample, they are placed in appearance In device.Consumer for the preference of taste by allowing consumer be dipped in described container by disposable lip gloss application device And taste described sample and test.Then consumer selects the sample of their preference.Consumer is also commented with the scale of-4 to+4 Fixed each sample (-4 is " revulsing ", and+4 is " extremely liking ").By direct with sample A for each in sample B and C Relatively, the most each consumer tests sample A is to sample B, and then sample A is to sample C.The preference that these are compared and evaluation In being described below.

The above results shows, sample A by the degree of preference and assessed rank apparently higher than sample B.Specifically, sample Product A (the R1/R2/R3/R4 ratio that it has is 1/2/2/4) by the degree of preference and assessed rank apparently higher than sample B (the R1/R2/R3/R4 ratio that it has is 1/ > 100/ > 100/ > 100).

The above results also shows, sample A is by the degree of preference and assessed is superior to sample C.Specifically, sample By the degree of preference and the assessed sample B that is superior to, (it has A (the R1/R2/R3/R4 ratio that it has is 1/2/2/4) R1/R2/R3/R4 ratio be > 100/0/2/2).

Embodiment 3: ratio

In order to prepare foregoing embodiments A, B and C and D, vaseline is heated to about 70 DEG C, and by other component at high temperature It is mixed into.For all embodiments, compositions is made to reach room temperature before the use.After being prepared for described sample, they are placed in In container.Consumer for the preference of taste by allowing consumer that disposable lip gloss application device is dipped described container In and taste described sample and test.Then consumer selects the sample of their preference.Consumer is also commented with the scale of-4 to+4 Fixed each sample (-4 is " revulsing ", and+4 is " extremely liking ").Preference and the evaluation compared for these are described in Hereinafter.

The above results shows, sample B is by the degree of preference and assessed is superior to sample A.Specifically, sample B (the R1/R2/R3/R4 ratio that it has is 1/2/2/4) (it has by the degree of preference and the assessed sample A that is superior to R1/R2/R3/R4 ratio be 1/25/25/50).

The above results also shows, sample D by the degree of preference and assessed rank apparently higher than sample C.Specifically, Sample D (the R1/R2/R3/R4 ratio that it has is 1/2/2/4) by the degree of preference and assessed rank apparently higher than sample C (the R1/R2/R3/R4 ratio that it has is 1/25/25/50).

Embodiment 4: content

In order to prepare foregoing embodiments A and B, vaseline is heated to about 70 DEG C, and other component is at high temperature mixed into. For all embodiments, compositions is made to reach room temperature before use.After being prepared for described sample, they are placed in container. Consumer for the preference of taste by allowing consumer be dipped by disposable lip gloss application device in described container and product Taste described sample to test.Then consumer selects the sample of their preference.Consumer also evaluates each with the scale of-4 to+4 Sample (-4 is " revulsing ", and+4 is " extremely liking ").During the preference compared for these and evaluation are described below.

The above results shows, sample B is by the degree of preference and assessed is superior to sample A.Specifically, sample B (its total saccharin+Herba Menthae+menthol content having is 10% [and R1/R2/R3/R4 ratio is 1/2/2/4]) is by preference Degree and assessed be superior to sample A (its total saccharin+Herba Menthae+menthol content having [and R1/R2/ that is 1.5% The ratio of R3/R4 is identical is 1/2/2/4]).

Dimension disclosed herein and value are not intended to be understood to be limited strictly to described exact value.On the contrary, unless separately Indicating outward, each such dimension each means recited value and the functionally equivalent scope around that numerical value.

Unless expressly excluded or limited, each file cited herein, draw including any intersection With or Patents or patent application, be incorporated by the most accordingly herein.Quoting any document is not to hold Recognize its for the disclosed herein or prior art of claimed any invention or recognize its independently or with appoint The what any combination of mode of its one or more list of references proposes, advises or discloses this type of invention any.If additionally, In this document, any implication or the definition of term are herein incorporated by reference in the literature any of same term contain with any Justice or definition conflict mutually, will be as the criterion with the implication or definition that give that term in this document.

Although illustrate and describe the present invention by specific embodiments, but aobvious and easy for those skilled in the art See, can make in the case of without departing from the spirit and scope of protection of the present invention many other change and modification.Therefore, The all these changes being intended in following claims in the scope of the invention and modification.

Claims

1. an oral care composition, described compositions comprises:

A) water insoluble carrier of the most about 80% to about 99%, described water insoluble carrier is selected from micro- Brilliant wax, paraffin, Cera Flava, vaseline, mineral oil, polybutene, silicone, natural oil, artificial oil, polyethylene or combinations thereof,

B) sweeting agent of the most about 0.5% to about 10%, described sweeting agent is selected from saccharin, tri-chloro galactose type Sucrose, stevioside, xylitol, aspartame, acesulfame potassium, monoammonium glycyrrhizinate or their mixture, and

C) annexing ingredient, described annexing ingredient is selected from sensory agent and the combination of flavoring agent, and described sensory agent is selected from menthol；3-1- Menthoxypropane-1,2-glycol, menthyl lactate；N, 2,3-trimethyl-2-butanamide；N-ethyl-p-Herba Menthae Alkane-3-Methanamide；N-(4-Cyanomethylphenyl)-p-menthane carbosamided and combinations thereof, described flavoring agent is selected from Herba Menthae, Ilicis Purpureae, spice, vanilla, fruit, Citrus, cocoa, tea or combinations thereof；

Wherein sensory agent is about 0.25 to about 2.0 with the ratio of flavoring agent, and flavoring agent is about by weight with the ratio of sweeting agent 1.0 to about 4.0, sensory agent is about 1.0 to about 4.0 by weight with the ratio of sweeting agent, and described flavoring agent is plus described Sensory agent is about 0.4 to about 40 by weight with the ratio of sweeting agent.

2. oral care composition as claimed in claim 1, described compositions also comprises monoalkyl phosphoric acid esters.

3. oral care composition as claimed in claim 1 or 2, wherein flavoring agent is about by weight with the ratio of sweeting agent 1.5 to about 2.5.

4. oral care composition as claimed any one in claims 1 to 3, wherein sensory agent and the ratio of sweeting agent are by weight Gauge is about 1.5 to about 2.5.

5. the oral care composition as according to any one of Claims 1-4, wherein said compositions comprises by weight about The flavoring agent of 1% to about 10% and the sensory agent of by weight about 1% to about 10%.

6. the oral care composition as according to any one of claim 1 to 5, wherein flavoring agent adds sensory agent and sweeting agent Ratio by weight be about 2.0 to about 8.0.

7. oral care composition as claimed in claim 1, wherein said oral care composition is by insoluble as described water The property vaseline of carrier, the saccharin as described sweeting agent, the Herba Menthae as described flavoring agent and thin as described sensory agent Lotus alcohol forms.

8. oral care composition as claimed in claim 1, wherein said oral care composition is carried by described water-insoluble Body, sweeting agent and annexing ingredient composition.