CN102625722A

CN102625722A - Oral care compositions and methods

Info

Publication number: CN102625722A
Application number: CN2010800358223A
Authority: CN
Inventors: 贾扬塔·拉贾亚; 阿里夫·阿里·拜格
Original assignee: Procter and Gamble Ltd
Current assignee: Procter and Gamble Ltd; Procter and Gamble Co
Priority date: 2009-08-17
Filing date: 2010-08-17
Publication date: 2012-08-01
Also published as: AU2010284339B2; WO2011022343A2; CN106176306A; AU2010284339A1; CA2772119C; MX2012001994A; EP2467192A2; BR112012003708A2; CA2772119A1; WO2011022343A3

Abstract

Advantageous oral care composition can include a water insoluble carrier, sweetener, and an additional component selected from the group consisting of flavors, sensates, and combinations thereof.

Description

Oral care composition and method

Invention field

Present patent application relates to oral care composition and correlation technique thereof, the various combination that said oral care composition has water-msoluble ingredients and has sweeting agent, flavoring agent and/or sensory agent.

Background of invention

In history, oral care product such as dentifrice and collutory have been used to cleaning oral cavity.Because these products obtain their cleaning effect usually through surfactant, and surfactant provides better result in general under water base environment, so these products generally use the base material of water-soluble component as them.Yet with regard to deposition, these water soluble binders have some shortcomings.At first, said water soluble binders owing to interacting with saliva and being rinsed out apace, this means that the time of staying that is deposited on any material in these base materials is very short usually in the oral cavity.Therefore, need in the oral cavity, to provide the oral care composition and the method for better deposition characteristics.

In addition, using and approve that mouthfeel is an importance of oral care product for the person of boosting consumption.Therefore, consumer products companies not only is devoted to the product with beneficial effect is provided, but also said product is accepted by consumer.Therefore, need to improve the taste combination that is used for oral care product.

Summary of the invention

One embodiment of the invention relate to oral care composition, and said compositions is made up of water insoluble carrier, sweeting agent and annexing ingredient basically, and said annexing ingredient is selected from the group of being made up of following: sensory agent, flavoring agent and their combination.Said oral care composition is designed for and is applied in the oral cavity.

According to another embodiment; The present invention relates to oral care composition; Said compositions comprises about 50% to about 99% water insoluble carrier; About 0.5% to about 10% sweeting agent and annexing ingredient, said annexing ingredient is selected from the group of being made up of following: sensory agent, flavoring agent and their combination.Said oral care composition is designed for and is applied on the tooth.

In another embodiment, the present invention relates to oral care composition, said compositions is made up of vaseline, glucide, Oleum menthae and menthol basically.Said oral care composition is designed for and is applied on the tooth.

According to disclosing of hereinafter, can understand these and other embodiment better.

Detailed Description Of The Invention

Definition

Term as used herein " sensory agent " is meant that wherein the main effect in the oral cavity is to give sensation, the for example material of warming sense, cooling feeling and/or sensation of pricking.

Term as used herein " flavoring agent " is meant that wherein the main effect in the oral cavity is to give the material of taste, does not comprise sweeting agent.

Term as used herein " sweeting agent " is meant that wherein the main effect in the oral cavity is to give the material of sweet taste.

Term as used herein " water-insoluble " is meant the material that in water, dissolves less than about 10%, only if specify in addition.

When using jointly with numerical value, term " about " is meant the scope of numerical value+/-10% thereafter; So " about 10% " will mean 9.0% to 11.0%.

Except as otherwise noted, all percentage ratio of this paper and ratio are all by the weight of total compsn.

Detailed Description Of The Invention

Oral care product has different functions in the oral cavity.For example, when the expectation cleaning oral cavity, toothpaste or collutory generally will be noted by consumer.In order this cleaning beneficial effect to be provided, the general water soluble binders of all using foaming of paste and lotion.The foam that in these base materials, provides provides cleaning efficacy, said cleaning efficacy can with brush or active compound combined use so that more cleaning beneficial effect to be provided.Other oral care product provides more Aesthetic Function, like breath freshening.These products take various forms from soluble to peppermint candy.Most of aspects that have jointly of these products are that they generally are water miscible.Since the said component that beneficial effect is provided in the oral cavity by saliva dissolves and/or wash away, the water solublity intrinsic limitation of these products they the persistent period of its beneficial effect can be provided.

Have surprisingly been found that at present water insoluble carrier can be used in the oral care composition to improve MC component sending to the oral cavity.In these MC components some comprise for example sensory agent, flavoring agent and sweeting agent.The use of water insoluble carrier makes the said time of staying of MC component in the oral cavity longer, and therefore longer lasting beneficial effect is provided.For example, in some cases, said water insoluble carrier can in the oral cavity, use in addition one hour or the longer time after come to light.

Water insoluble carrier

Water-msoluble ingredients can be used as the carrier among the present invention.In various embodiment, the dissolving of said water insoluble carrier in water is less than about 10%, 8%, 5%, 4%, 3%, 2% or 1%.In one embodiment, the content of said water insoluble carrier counts about 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65% to about 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99% and/or their any combination by the weight of said compositions.In different embodiments, the content of said water insoluble carrier counts about 80% to about 99%, about 80% to about 95% by the weight of said compositions, or about 85% to about 95%.In another embodiment, said water insoluble carrier is counted at least about 75% by the weight of said oral care composition.In another embodiment, said water insoluble carrier in water be water-insoluble be again non-swellability.In other embodiments, said water insoluble carrier comprises gel, liquid or their mixture.Said water insoluble carrier can be the combination of two kinds or more kinds of water-msoluble ingredients.

In one embodiment, said water insoluble carrier is selected from the group of being made up of following: native paraffin, synthetic wax, vaseline, rubber, elastomer, plastics, polrvinyl chloride, nylon, polyvinyl acetate, natural oil, artificial oil, fat, silicone, hydrocarbon, quintessence oil, caprylic/capric triglyceride, polybutene, oleic acid, stearic acid, fluorocarbon, polyurethane prepolymer, polyethylene, polystyrene, polypropylene and their mixture.In another embodiment, said water insoluble carrier is a PDMS natural gum, or PDMS natural gum and the mixture (referring to United States Patent (USP) 6,074,654) that removes the MQ resin that obtains like the volatility isoparaffin of desolvating.

In one embodiment, said water insoluble carrier comprises native paraffin, synthetic wax or their combination.Native paraffin comprises for example animal, plant and mineral wax.Animal wax comprises for example Cera Flava, lanoline, shellac wax, Chinese wax etc.Vegetable wax comprises Brazil wax, candelilla wax, bayberry, Caulis Sacchari sinensis etc., and mineral wax comprises fossil waxes and ceresine (ozocerite, ceresin, brown coal) and pertroleum wax such as paraffin, microwax etc.In one embodiment, the wax of this paper is native paraffin, and said native paraffin is selected from the group of being made up of following: Cera Flava, candelilla wax, candela wax, Brazil wax, paraffin, microwax, Fischer-Tropsch wax and their mixture.

The instance of natural oil includes but not limited to vegetable oil (deriving from Semen Maydis oil), soybean oil, Oleum Gossypii semen, Petiolus Trachycarpi oil, Oleum Cocois, mineral oil, animal oil (deriving from fish oil) etc.The instance of artificial oil includes but not limited to silicone oil etc.In one embodiment, said water-msoluble ingredients comprises natural oil.In another embodiment, said natural oil comprises mineral oil.In one embodiment, mineral oil amount with about 30% to about 50% in said compositions exists, and exists with about 35% to about 45% amount in another embodiment.

Elastomeric instance includes but not limited to ethylene-EP rubbers, EP rubbers, styrene-ethylene-propylene-styrene rubber and their combination, and these can randomly further mix with wax.

In one embodiment, said water insoluble carrier comprises microwax, paraffin, Cera Flava, vaseline, mineral oil, polybutene, silicone, natural oil, artificial oil, polyethylene or their combination.In another embodiment, said water insoluble carrier is selected from the group of being made up of following: polybutene, silicone, vaseline and their combination.In another embodiment, said carrier comprises vaseline.In another embodiment, said carrier is made up of vaseline basically.

When a plurality of concrete embodiment of water insoluble carrier was listed in this paper, to imagine other suitable compositions also be suitable and belong to category of the present invention.

Sensory agent

The present invention can comprise provides the sensation beneficial effect, often is called as one or more components of sensory agent.Sensory agent can have attribute of sensation, like warming sense, sensation of pricking or cooling feeling.Suitable sensory agent comprises for example menthol; Menthyl lactate; Folic alcohol; Camphora; Clove bud oil; Eucalyptus oil; The anethole; Methyl salicylate; Cineole; Cortex cinnamomi japonici (Ramulus Cinnamomi); The 1-8 menthyl acetate; Acetaminol;

alkane ketone; α-Zi Luolantong; The methylol anethole; Thymol; Linalool; Benzaldehyde; Be the cinnamic aldehyde glycerine acetal that CGA knew; And their mixture.

In one embodiment, said sensory agent comprises coolant.Coolant can be any in various material.Comprise that these materials in the present invention are Methanamide, menthol, ketal, glycol and their mixture.Some instances of Methanamide coolant comprise for example to terpane carbamyl reagent; N-ethyl-right-terpane-3-Methanamide like commercial being known as " WS-3 "; Be known as the N of " WS-23 "; 2,3-trimethyl-2-isopropyl butyramide be known as G-180 and by the N-(4-cyano methyl phenyl) of Givaudan supply-right-menthane carbosamided.G-180 is generally in flavor oils, as providing with 7.5% solution in Oleum Menthae Rotundifoliae or the Oleum menthae.The instance of menthol coolant comprises for example menthol; By the 3-1-menthoxypropane-1 that is called TK-10 that Takasago makes, 2-glycol, the menthone glycerine acetal of making by Haarmann and Reimer that is called MGA and the menthyl lactate of making by Haarmann and Reimer that is called Frescolat

.Term menthol used herein and menthyl comprise dextrorotation and the laevoisomer and their racemic mixture of these chemical compounds.

In one embodiment; Said sensory agent comprises coolant; Said coolant is selected from the group of being made up of following: menthol, 3-1-menthoxypropane-1; 2-glycol, menthyl lactate, N, 2,3-trimethyl-2-isopropyl butyramide, N-ethyl-right-terpane-3-Methanamide, N-(4-cyano methyl phenyl)-right-menthane carbosamided and their combination.In another embodiment, said sensory agent comprises menthol, N, 2, and 3-trimethyl-2-isopropyl butyramide, N-(4-cyano methyl phenyl)-right-menthane carbosamided or their combination.In one embodiment, said sensory agent comprises menthol.In another embodiment, said sensory agent is made up of menthol basically.

The amount of used sensory agent normally depends on a kind of preference such as factors such as the type of expectation and effect intensity.By the weight of said oral care composition, sensory agent can exist with about 40% amount at the most.In various embodiment, said sensory agent can with about 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9% or 10% to about 2%, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 15%, 20%, 30% 40% or their amount of any combination exist.In various embodiment, said sensory agent exists with about 0.1% to about 20.0%, about 1% to about 10% or about 3% to about 6% amount by the weight of said total compsn.

Flavoring agent

The present invention can comprise one or more components that the flavoring agent beneficial effect is provided.Said flavor components can be selected from natural and synthetic flavoring agent.Natural flavour mountaineous dose for example can comprise the oil derived from plant leaf blade, flower, fruit or the like.Some representational flavoring agent comprise for example vanilla, Salvia japonica Thunb., origanum, parsley oil, Oleum Menthae Rotundifoliae, Oleum Cinnamomi, wintergreen oil (methyl salicylate) and Fructus Piperis peppermint oil.Be used for synthetical, the natural or synthetic fruit flavor agent of also can be of this paper.These for example comprise, tangerine oil comprises that Fructus Citri Limoniae, orange, rubber, Fructus Vitis viniferae, Citrus aurantium Linn., Fructus Pruni and Fructus Citri grandis and fruit essence comprise Fructus Mali pumilae, Fructus Fragariae Ananssae, Fructus Pruni pseudocerasi, orange, Fructus Ananadis comosi or the like; The deutero-flavoring agent of Kidney bean and nut is like coffee, cocoa, cola, Semen arachidis hypogaeae, Semen Armeniacae Amarum or the like.These can be any form, comprise liquid, powder etc.In addition, can comprise the flavoring agent that is adsorbed onto on the hydrophilic matrix, like " spray-dired " flavoring agent.In addition, can comprise the flavoring agent of sealing.

In one embodiment, said flavoring agent is selected from Herba Menthae, Ilicis Purpureae, spice, vanilla, fruit, Citrus, cocoa, tea or their combination.In one embodiment, said flavor components is selected from the group of being made up of following: Mentha arvensis L. syn.M.haplocalyxBrig, Herba Menthae Rotundifoliae, vanilla, Cortex Cinnamomi, Ilicis Purpureae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Vitis viniferae, Fructus Mali pumilae and their combination.In another embodiment, said flavor components comprises blended Herba Menthae, Mentha arvensis L. syn.M.haplocalyxBrig, Herba Menthae Rotundifoliae, Ilicis Purpureae or their combination.In an additional embodiment, said flavor components comprises Mentha arvensis L. syn.M.haplocalyxBrig.

The amount of used flavoring agent normally depends on a kind of preference such as factors such as the type of expectation and effect intensity.Flavoring agent can exist with about 40% amount at the most.In different embodiments, said flavoring agent can with about 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9% or 10% to about 2%, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 15%, 20%, 30% 40% or their amount of any combination exist.In various embodiment, said flavoring agent exists with about 0.1% to about 20.0%, about 1% to about 10% or about 3% to about 6% amount by the weight of said total compsn.

Sweeting agent

The present invention can comprise one or more components that the sweeting agent beneficial effect is provided.Suitable sweeting agent comprises natural and synthetical sweeting agent.Said sweeting agent can be water miscible or water-insoluble.Said sweeting agent also can be intensive sweeting agent.

Some instances of sweeting agent comprise dextrose, sucrose, maltose, dextrin, exsiccant Nulomoline, mannose, xylose, ribose, glucose, fructose, levulose, galactose, corn syrup, high-fructose corn syrup, corn-syrup solids, boiling starch, aspartame, glucide, sugar alcohol such as sorbitol, xylitol, maltose alcohol, different Fructus Hordei Germinatus and hydrogenant starch.

Intensive sweeting agent often is two peptidyls.Some instances of intensive sweeting agent comprise monellin, haumatoccous danielli and L-aspartyl L-phenylalanine methyl ester and soluble saccharin salt.

In one embodiment, said sweeting agent is selected from the group of being made up of following: the Nulomoline of dextrose, sucrose, maltose, dextrin, no juice, mannose, xylose, ribose, glucose, fructose, levulose, galactose, corn syrup, high-fructose corn syrup, corn-syrup solids, boiling starch, aspartame, glucide, sugar alcohol, hydrogenant starch, monellin, haumatoccous danielli, L-aspartyl L-phenylalanine methyl ester, soluble saccharin salt and their combination.In another embodiment, said sweeting agent is selected from the group of being made up of following: glucide, sucralose, stevioside (Rebiana), xylitol, aspartame, acesulfame potassium, monoammonium glycyrrhizinate and their mixture.In another embodiment, said sweeting agent comprises glucide, sucralose, stevioside or their combination.In one embodiment, said sweeting agent comprises glucide.In another embodiment, said sweeting agent is made up of glucide basically.

The amount of sweeting agent changes along with the content of the sweeting agent of selected sweeting agent type and expectation.Sweeting agent can exist with about 20% amount at the most.In other embodiments; Weight by said oral care composition; Said sweeting agent can be with about 0.1%, 0.15%, 0.25%, 0.5%, 0.75%, 1%, 1.25%, 1.5%, 1.75%, 2%, 2.25%, 2.5%, 2.75%, 3%, 4%, 5% or 10% to about 1%, 2%, 3%, 4%, 5%, 10% or 20%, or the amount of their any combination exists.In various embodiment, said flavoring agent exists with about 0.1% to about 10.0%, about 1% to about 5% or about 1.5% to about 3% amount by the weight of said total compsn.

Other component

Except listed those of preceding text the component, said oral care composition can additionally comprise other component.An instance of these annexing ingredients comprises affinity reagent.One group of affinity reagent is organophosphorus ester.Suitable organophosphorus compounds has intensive affinity to said dental surface and has enough surface combination tendencies to separate gettering thin film protein and residue attached to it.The phosphate-based of organophosphorus ester oneself is attached to cation with them; Specifically in the site of tooth or some other positively chargeds; As on the calcium ion of the protein residue on the mucomembranous surface; Therefore and the hydrophobic parts of said molecule is anchored to said surface, thereby it is modified to hydrophobic.Said phosphate-basedly provide cation and charged surface bonding/combination rapidly through static reciprocal action, hydrogen bond or complexing, this causes, and said organophosphorus ester deposits to be formed on handled lip-deep coating rapidly when using.Intensive bonding causes the longer reservation of said coating or durability and affinity.

An ester, diester or three esters of the instance of suitable organophosphorus compounds for representing, wherein Z by following formula ¹, Z ²Or Z ³Can be identical or different, at least one is an organic moiety, preferably is selected to have 6 to 22 carbon atoms, and is optional by one or more phosphate-based substituted straight or branched alkyl or alkenyls; Alkoxylated alkyl group or oxyalkylated thiazolinyl.

Some preferred reagent comprise alkoxylated alkyl group or the thiazolinyl phosphate ester of being represented by structure:

R wherein ¹Represent 6 to 22 carbon atoms of straight or branched, randomly by one or more phosphate-based substituted alkyl or alkenyls; N and m are 2 to 4 individually and respectively, and a and b are 0 to 20 individually and respectively; Z ²And Z ³Can be identical or different, each represents hydrogen, alkali metal, ammonium, protonated alkylamine or protonated sense alkylamine such as alkanolamine or R ¹-(OC _nH _2n) _a(OC _mH _2m) _b-Ji.Preferably, R ¹Be the alkyl of at least 10 carbon atoms, and a and b are no more than 10 separately so that keep overall hydrophobic character of said organophosphorus ester and the hydrophobicity degree of giving said surface.

In one embodiment; Said affinity reagent comprises one, two and trialkyl and alkyl (many) alkoxyl phosphate ester, like 1-isobutyl-3,5-dimethylhexylphosphoric acid, Tryfac 5573, laureth-1 phosphate ester, laureth-3 phosphate ester, laureth-9 phosphate ester, dilauryl polyoxyethylene ether-10 phosphate ester, three lauryl alcohol polyethers-4 phosphate esters, C _12-18PEG-9 phosphate ester and salt thereof.Manyly can be purchased acquisition from suppliers, said supplier comprises Croda; Rhodia; Nikkol Chemical; Sunjin; Alzo; Huntsman Chemical; Clariant and Cognis.In one embodiment, said affinity reagent comprises monoalkyl phosphoric acid esters.

Another instance of annexing ingredient comprises active component.Some instances of active component comprise the various fluoride salts that are used for the prevention of dental caries and Remineralization; Through using antimicrobial, like triclosan, hexadecylpyridinium chloride

, stannous fluoride, zinc citrate or quintessence oil prevention gingivitis; With through using composition, like strontium chloride, stannous fluoride or potassium nitrate control anaphylaxis; The pyrophosphate that can be used as anticalculus agent; Can be used to bleach peroxide with antibacterial; Can be used to corrosion protection or irritated protection with polymer-mineral matter surfactant; Polymer like phosphorylation; Be attached to the poly phosphate on the tooth specifically, or metal ion, deposit to Ya Xi, zinc or the copper of the undissolved chemical compound on the tooth like formation.These active substances can use or make up use separately.

Another instance of annexing ingredient comprises adhesive component.The present invention can comprise the adhesive component of safe and effective amount, and its content is generally about 1% to about 75% by the weight of said compositions.In other embodiments, said adhesive component about 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40% to about 10%, 15%, 20%, 50%, 60%, 75% or their scope of any combination in.In a particular, the amount of said adhesive component is about 10.0% to about 60.0%.In another embodiment, the amount of said adhesive component is about 1% to about 15%.

In general, adhesive component is by moisture-activated the time, become heavy-gravity hydrophilic particle or hydrophilic liquid.With regard to regard to those of moisture-activated, moisture for example can be present in the oral care composition self, and is present in the user oral cavity.In various embodiment, the adhesive component of this paper is mucoadhesive property, be adhered to said tooth, hydrophilic, water miscible, have swelling character or their any combination during with contact with moisture.

In one embodiment, said adhesive component is selected from the group of being made up of following: glycerol, polyalkylene oxide, sorbitol, polyethylene glycol oxide, carbomer, polyacrylamide, polypeptide, natural gum; Synthesized polymer natural gum; AVE/MA; AVE/MA/IB; The copolymer of maleic acid or anhydride and ethylene, styrene and/or isobutene., polyacrylic acid and/or its polyacrylate, gather the itaconic acid, mucoadhesive polymer, the hydrophilic sexual intercourse colloid of water solublity, saccharide, cellulose, cellulosic resin, acrylic resin, their derivant and their mixture.The instance of this type of material comprises karaya, guar gum, gelatin, Algin, sodium alginate, Tragacanth, chitosan, acrylamide polymer, carboxypolymethylene, polyvinyl alcohol, polyamines, gathers salt and the salt-mixture of quaternary compound, polyvinyl pyrrolidone or its copolymer, cationic polyacrylamide polymer, AVE/MA; Polymeric acid, polymer salt and their copolymer, gather itaconate, polyol, their derivant and their mixture.

In another embodiment, said adhesive component is selected from the group of being made up of following: cellulose, cellulose derivative (like methylcellulose, carboxymethyl cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, corn starch and their mixture), starch, starch derivatives, sugar, sugar derivatives, PEO, Polyethylene Glycol, polyvinyl alcohol, carrageenin, alginate, karaya, xanthan gum, guar gum, gelatin, Algin, Tragacanth, chitosan, acrylamide polymer, carboxypolymethylene, polyamines, gather the salt of quaternary compound, polyvinyl pyrrolidone, AVE/MA, AVE/MA, the salt-mixture of AVE/MA, polymeric acid, polymer salt, polyol and their mixture.

Ratio

In addition; Have surprisingly been found that; Be delivered to particular combination and/or the beneficial effect that ratio provides consumer highly to approve of sweeting agent, sensory agent and/or the flavoring agent in oral cavity through water insoluble carrier, as fresh feel, clean sense, tooth smoothly feel, tooth smooth feeling and breath freshening sense.In addition, also find surprisingly, when having sweeting agent, consumer to the acceptability of the oral care composition of water insoluble carrier base for the highest.

Therefore; Although the water insoluble carrier system provides some extra motilities on the prescription of the system that derives from the water-solubility carrier base; But in said system, as if special ratio ranges is arranged, so that the acceptable product of prosumer for sweeting agent, flavoring agent and sensory agent.Therefore; Compositions of the present invention with the component that exists with concrete ratio disclosed herein it is believed that to those compositionss that do not comprise component disclosed herein or that exist with different ratios provides excellent flavoring agent beneficial effect, and therefore provides consumer more acceptable product.Because consumer's acceptance helps to promote the use of said product, this occupies an important position in the product development of success.

First ratio is the weight (" R1 ") of sensory agent weight ratio flavoring agent.This ratio calculates divided by flavoring agent weight % with sensory agent weight %.In one embodiment, this ratio is about 0 to about 4.0.In another embodiment, this ratio is about 0.25 to about 2.0.In another embodiment, this ratio is about 1.0.

Second ratio is the flavoring agent weight ratio sweeting agent weight (" R2 ") in oral care composition.In order to calculate this ratio, with the weight % of flavoring agent weight % divided by sweeting agent.In one embodiment, this ratio is about 0 to about 20.In another embodiment, said ratio is about 1.0 to about 4.0.In another embodiment, said ratio is about 1.5 to about 2.5.In another embodiment, said ratio is about 2.0.

Next ratio is about sensory agent weight ratio sweeting agent weight (" R3 ").This ratio calculates divided by sweeting agent weight % with sensory agent weight %.In one embodiment, this ratio is about 0 to about 20.In another embodiment, said ratio is about 1.0 to about 4.0.In another embodiment, said ratio is about 1.5 to about 2.5.In another embodiment, said ratio is about 2.0.

Last ratio is sensory agent weight and flavoring agent weight ratio sweeting agent weight (" R4 ").This ratio through with the weight % of the weight % of sensory agent and flavoring agent mutually adduction calculate with the weight % of sum divided by sweeting agent.In one embodiment, this ratio is about 0.4 to about 40.In various embodiment, this ratio is about 2.0 to about 8.0, about 3.0 to about 7.0, or about 3.0 to about 5.0.In an additional embodiment, said ratio is about 4.0.

These ratios can be used to help to limit consumer for the acceptable oral care product of water-insoluble base.For example, R1 is about 0.25 to about 4.0 in one embodiment, and R2 is about 0.2 to about 20, and R3 is about 0.2 to about 20.In another embodiment, R1 is about 0.5 to about 2.0, and R2 is about 1.0 to about 4.0, and R3 is about 1.0 to about 4.0.In another embodiment, R1 is about 1.0, R2 be about 2.0 and R3 be about 2.0.

Oral care composition

The various combinations of water insoluble carrier, sweeting agent, flavoring agent and/or sensory agent are possible, and are considered to belong to category of the present invention, and hereinafter has been discussed some concrete combinations.

In one embodiment, oral care composition comprises water insoluble carrier, sweeting agent and annexing ingredient, and said annexing ingredient is selected from sensory agent, flavoring agent or their combination.In another embodiment, oral care composition is made up of water insoluble carrier, sweeting agent and annexing ingredient basically, and said annexing ingredient composition is selected from sensory agent, flavoring agent or their combination.These two embodiments all are designed for and are administered in the said oral cavity.In one embodiment, said oral care composition is designed for and is administered on the tooth.

In another embodiment, said oral care composition comprises at least 75% water insoluble carrier by weight.In another embodiment, said water insoluble carrier counts about 70% to about 99% by the weight of said oral care composition.In an additional embodiment, said water insoluble carrier counts about 50% to about 99% by the weight of said oral care composition.

In another embodiment, said water insoluble carrier is rubber and/or native paraffin and/or synthetic wax and/or polrvinyl chloride and/or nylon and/or fluorocarbon and/or polyurethane prepolymer and/or polyethylene and/or polystyrene and/or polypropylene and/or vaseline and/or polyvinyl acetate and/or natural oil and/or artificial oil and/or fat and/or silicone and/or hydrocarbon and/or caprylic/capric triglyceride and/or oleic acid and/or stearic acid and/or their mixture.In one embodiment, said water insoluble carrier comprises microwax and/or paraffin and/or Cera Flava and/or vaseline and/or mineral oil and/or polybutene and/or silicone and/or natural oil and/or artificial oil and/or polyethylene and/or their combination.In another embodiment, said water insoluble carrier is selected from the group of being made up of following: polybutene and/or silicone and/or vaseline and/or their combination.In another embodiment, said carrier comprises vaseline.In another embodiment, said carrier is made up of vaseline basically.

In another embodiment, said oral care composition comprises about by weight 0.5% to about 10% sweeting agent.In one embodiment, said sweeting agent is selected from the group of being made up of following groups: dextrose, fructose, corn syrup, high-fructose corn syrup, aspartame, glucide, sugar alcohol and their mixture.In one embodiment, said sweeting agent is selected from the group of being made up of following: glucide, sucralose, stevioside, xylitol, aspartame, acesulfame potassium, monoammonium glycyrrhizinate and their mixture.In another embodiment, said sweeting agent comprises glucide, sucralose, stevioside or their combination.

In another embodiment, the weight % sum of said sweeting agent and said annexing ingredient is less than about 25%.In another embodiment, the weight % sum of said sweeting agent and said annexing ingredient is less than 25%.In an additional embodiment, the weight % sum of said sweeting agent and said annexing ingredient is about 8% to about 15%.

In one embodiment, said annexing ingredient comprises flavoring agent.In another embodiment, said flavoring agent is selected from the group of being made up of following: Mentha arvensis L. syn.M.haplocalyxBrig, Herba Menthae Rotundifoliae, vanilla, Cortex Cinnamomi, Ilicis Purpureae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Vitis viniferae, Fructus Mali pumilae and their combination.In another embodiment, said flavor components comprises blended Herba Menthae, Mentha arvensis L. syn.M.haplocalyxBrig, Herba Menthae Rotundifoliae, Ilicis Purpureae or their combination.In an additional embodiment, said flavor components is made up of Herba Menthae basically.In one embodiment, the ratio of flavoring agent and sweeting agent is about 0.2 to about 20.

In one embodiment, said annexing ingredient comprises sensory agent.In one embodiment, said sensory agent comprises coolant.In another embodiment, said sensory agent is selected from the group of being made up of following: menthol, menthyl lactate, folic alcohol, Camphora, clove bud oil, Eucalyptus oil, anethole, methyl salicylate, cineole, Cortex cinnamomi japonici (Ramulus Cinnamomi), acetic acid 1-8 menthyl ester, acetaminol,

alkane ketone, α-Zi Luolantong, methylol anethole, thymol, linalool, benzaldehyde, cinnamic aldehyde glycerine acetal and their mixture.In another embodiment; Said sensory agent is selected from the group of being made up of following: menthol, 3-1-menthoxypropane-1; 2-glycol, methyl lactate, N; 2,3-trimethyl-2-isopropyl butyramide, N-ethyl-right-terpane-3-Methanamide, N-(4-cyano methyl phenyl)-right-menthane carbosamided and their combination.In another embodiment, said sensory agent comprises menthol, N, 2, and 3-trimethyl-2-isopropyl butyramide, N-(4-cyano methyl phenyl)-right-menthane carbosamided; Or their combination.In an additional embodiment, the said ratio of sensory agent and sweeting agent is about 0.2 to about 20.

In another embodiment, said annexing ingredient comprises the combination of flavoring agent and sensory agent.In one embodiment, flavoring agent adds that the ratio of sensory agent and sweeting agent is about 0.4 to about 40 by weight.In another embodiment; The ratio of sensory agent and flavoring agent is about 0.5 to about 2.0 by weight; The ratio of flavoring agent and sweeting agent is about 1.0 to about 4.0 by weight; The ratio of sensory agent and sweeting agent is about 1.0 to about 4.0 by weight, and flavoring agent adds that the ratio of sensory agent and sweeting agent is about 2.0 to about 8.0 by weight.In an additional embodiment, said oral care composition comprises about by weight 1% to about 10% flavoring agent and about by weight 1% to about 10% sensory agent.

In one embodiment; Said oral care composition comprises water-solubility carrier, and said carrier comprises microwax and/or paraffin and/or Cera Flava and/or vaseline and/or mineral oil and/or polybutene and/or silicone and/or natural oil and/or artificial oil and/or polyethylene; And flavoring agent, said flavoring agent comprises Mentha arvensis L. syn.M.haplocalyxBrig and/or Herba Menthae Rotundifoliae and/or vanilla and/or Cortex Cinnamomi and/or Ilicis Purpureae and/or Herba Menthae and/or Fructus Fragariae Ananssae and/or Fructus Vitis viniferae and/or Fructus Mali pumilae; And sweeting agent, said sweeting agent comprises dextrose and/or fructose and/or corn syrup and/or high-fructose corn syrup and/or aspartame and/or glucide and/or sugar alcohol; And sensory agent, said sensory agent comprises menthol and/or menthyl lactate and/or folic alcohol and/or Camphora and/or clove bud oil and/or eucalyptus oil and/or anethole and/or methyl salicylate and/or eucalyptol and/or Cortex Cinnamomi and/or acetic acid 1-8 menthyl ester and/or acetaminol and/or

alkane ketone and/or α-Zi Luolantong and/or methylol anethole and/or thymol and/or linalool and/or benzaldehyde and/or cinnamic aldehyde glycerol acetonide; Wherein the ratio of sensory agent and flavoring agent is about 0.5 to about 2.0 by weight; And/or the ratio of flavoring agent and sweeting agent is about 1.0 to about 4.0 by weight; And/or the ratio of sensory agent and sweeting agent is about 1.0 to about 4.0 by weight, and/or flavoring agent adds that the ratio of sensory agent and sweeting agent is about 2.0 to about 8.0 by weight.

In a concrete embodiment; Said oral care composition is made up of water insoluble carrier, sweeting agent and annexing ingredient; Said annexing ingredient is selected from the group of being made up of following: sensory agent, flavoring agent and their combination; Wherein the ratio of sensory agent and flavoring agent is about 0.5 to about 2.0 by weight; And/or the ratio of flavoring agent and sweeting agent is about 1.0 to about 4.0 by weight, and/or the ratio of sensory agent and sweeting agent is about 1.0 to about 4.0 by weight, and/or flavoring agent adds that the ratio of sensory agent and sweeting agent is about 2.0 to about 8.0 by weight.In another concrete embodiment; Oral care composition is made up of vaseline, glucide, Oleum menthae and menthol basically; And set and be used for application tooth; Wherein the ratio of sensory agent and flavoring agent is about 0.5 to about 2.0 by weight; And/or the ratio of flavoring agent and sweeting agent is about 1.0 to about 4.0 by weight, and/or the ratio of sensory agent and sweeting agent is about 1.0 to about 4.0 by weight, and/or flavoring agent adds that the ratio of sensory agent and sweeting agent is about 2.0 to about 8.0 by weight.In another embodiment, flavoring agent adds that the ratio of sensory agent and sweeting agent is about 0.4 to about 40 by weight.In another embodiment; The ratio of sensory agent and flavoring agent is about 1.0 by weight; The ratio of flavoring agent and sweeting agent is about 2.0 by weight, and the ratio of sensory agent and sweeting agent is about 2.0 by weight, and flavoring agent adds that the ratio of sensory agent and sweeting agent is about 4.0 by weight.

In one embodiment, said compositions does not contain surfactant, grinding agent, fluoride source, therapeutic agent active substance, mucoadhesive, polybutene, silicone and/or antimicrobial reagent.In one embodiment, said oral care composition is not a dentifrice.In another embodiment, said oral care composition is not a collutory.In another embodiment, said oral care composition is not a Denture adhesive.

In one embodiment, said oral care composition will be the form of liquid or gel.The said oral care composition of said liquid or gel form can use with application device.Said application device can with any MC application device, for example swab, brush, top are adorned foamy application device etc. and are used together.

Although preceding text have been discussed several embodiments, it is believed that other embodiments of discussing based on preceding text, for example the concrete kind of every kind of component, its percentage by weight and ratio also belong within the category of the present invention.

Method for using

Can be used to the compatible MC component of any and said water insoluble carrier of oral delivery like the oral care composition that this paper discussed.For example, oral care composition can be used as flavorants through in said oral care composition, comprising flavorants (as flavoring agent), or said compositions can be used as the active substance delivery vector through comprising active substance.

Do not accept the constraint of opinion, also it is believed that, therefore will beneficial effect be provided to consumer owing to when using, on tooth, form the water-insoluble layer.Therefore, said oral care composition can be used on tooth, form the water-insoluble barrier.Expect that some beneficial effects that this type of barrier has comprise: part reduces dental caries, dental plaque and dental calculus owing to antibacterial can not adhere on the tooth at least; At least part is owing to dentinal tubule's adhesion reduces sensitivity; At least part reduces corrosion and prophylaxis of teeth variable color owing to said coating turns round as the barrier to caustic; And in oral sensation impression and/or apparent overall improvement; Said outward appearance is widely with attractive in appearance, like gloss, brilliance, shinny, smoothness, slickness and oral cavity cleaning sense as characteristic.

Embodiment

Embodiment 1: various compositionss of the present invention

Following non-limiting examples further illustrates and has described said theme working of an invention scheme, has wherein mixed basic and optional ingredients.Should understand, providing of embodiment only is the purpose of explaining for example, and should not be interpreted as is the restriction to category of the present invention, because under the situation that does not deviate from the spirit and scope of the present invention, its many changes are possible.

For compositions B, E, I and the J for preparing preceding text embodiment,, and at high temperature other component is mixed into wherein at 95 ℃ of said waxes of following fusion.In order to prepare preceding text embodiment A, C, D, F, G, H and K, vaseline and/or Versagel are heated to about 70 ℃, and other component is at high temperature sneaked into.For all embodiment, make compositions before using, reach room temperature.

In addition, each in the foregoing description prescription also can be mixed with each other so that crossbred embodiment to be provided.

Embodiment 2: ratio

In order to prepare preceding text embodiment A, B and C, vaseline is heated to about 70 ℃, and other component is at high temperature sneaked into.For all embodiment, make compositions before using, reach room temperature.After having prepared said sample, they are placed container.Consumer for the preference of taste through letting consumer dip disposable lip gloss application device in the said container and tasting said sample and test.Consumer selects the sample of their preference then.Consumer also evaluates each sample (4 for " revulsing ", and+4 be " extremely liking ") with-4 to+4 scale.Each and sample A among sample B and the C are directly compared, so each consumer tests sample A is to sample B, sample A is to sample C then.Be described in hereinafter for these preference and evaluations relatively.

The above results shows, sample A by the degree of preference and the rank evaluated apparently higher than sample B.Specifically, sample A (the R1/R2/R3/R4 ratio that it has is 1/2/2/4) by the degree of preference and by the rank evaluated apparently higher than sample B (the R1/R2/R3/R4 ratio that it has is 1/＞100/＞100/＞100).

The above results also shows, sample A by the degree of preference and evaluated be superior to sample C.Specifically, sample A (the R1/R2/R3/R4 ratio that it has is 1/2/2/4) by the degree of preference and evaluated be superior to sample B (the R1/R2/R3/R4 ratio that it has for＞100/0/2/2).

Embodiment 3: ratio

In order to prepare preceding text embodiment A, B and C and D, vaseline is heated to about 70 ℃, and other component is at high temperature sneaked into.For all embodiment, make compositions before using, reach room temperature.After having prepared said sample, they are placed container.Consumer for the preference of taste through letting consumer dip disposable lip gloss application device in the said container and tasting said sample and test.Consumer selects the sample of their preference then.Consumer is also with each sample of-4 to+4 scale evaluation (4 are " revulsing ", and+4 be " extremely liking ").Be described in hereinafter for these preference and evaluations relatively.

The above results shows, sample B by the degree of preference and evaluated be superior to sample A.Specifically, sample B (the R1/R2/R3/R4 ratio that it has is 1/2/2/4) by the degree of preference and evaluated be superior to sample A (the R1/R2/R3/R4 ratio that it has is 1/25/25/50).

The above results also shows, sample D by the degree of preference and the rank evaluated apparently higher than sample C.Specifically, sample D (the R1/R2/R3/R4 ratio that it has is 1/2/2/4) by the degree of preference and by the rank evaluated apparently higher than sample C (the R1/R2/R3/R4 ratio that it has is 1/25/25/50).

Embodiment 4: content

In order to prepare preceding text embodiment A and B, vaseline is heated to about 70 ℃, and other component is at high temperature sneaked into.For all embodiment, make compositions reach room temperature before use.After having prepared said sample, they are placed container.Consumer for the preference of taste through letting consumer dip disposable lip gloss application device in the said container and tasting said sample and test.Consumer selects the sample of their preference then.Consumer is also with each sample of-4 to+4 scale evaluation (4 are " revulsing ", and+4 be " extremely liking ").Be described in hereinafter for these preference and evaluations relatively.

The above results shows, sample B by the degree of preference and evaluated be superior to sample A.Specifically, sample B (its total glucide+Herba Menthae+menthol content that has is 10% [and the R1/R2/R3/R4 ratio is 1/2/2/4]) by the degree of preference and evaluated be superior to sample A (its total glucide+Herba Menthae+menthol content that has is 1.5% [and the ratio of R1/R2/R3/R4 is identical be 1/2/2/4]).

Dimension disclosed herein is not intended to be understood that strictly to be limited to described exact value with value.On the contrary, except as otherwise noted, each such dimension all be meant the numerical value of quoting and the scope that is equal on the function of that numerical value.

Only if clearly get rid of or in other words restriction to some extent, each file of quoting among this paper comprises any cross reference or related patent U.S. Patent No. or patent application, all incorporates this paper in full into way of reference in view of the above.To quoting of any document all be not to recognize that its be this paper disclosed or receive claims protections any invention prior art or admit that it proposes, advises or disclose any this type of to invent independently or with the mode with any combination of any other one or more lists of references.In addition, if any implication or the definition conflict mutually of same term in any implication of term or definition and any document of incorporating this paper with way of reference in this document will be as the criterion with the implication or the definition of giving that term in this document.

Although explained and described the present invention with specific embodiments, it will be apparent to those skilled in the art that and under the situation that does not deviate from spirit of the present invention and protection domain, can make many other change and modification.Therefore, enclose and be intended to contain all these changes and the modification in the scope of the invention in claims.

Claims

1. oral care composition, said compositions comprises:

A) water insoluble carrier,

B) sweeting agent and

C) annexing ingredient, said annexing ingredient is selected from the group of being made up of following: sensory agent, flavoring agent and their combination;

The ratio of wherein said sensory agent and flavoring agent is about 0 to about 4.0, and the ratio of said flavoring agent and sweeting agent is about 0 to about 20 by weight, and the ratio of said sensory agent and sweeting agent is about 0 to about 20 by weight.

2. oral care composition as claimed in claim 1, said compositions also comprises monoalkyl phosphoric acid esters.

3. like the described oral care composition of aforementioned each claim, the ratio of wherein said sensory agent and flavoring agent is about 0.25 to about 2.0.

4. like the described oral care composition of aforementioned each claim, the ratio of wherein said flavoring agent and sweeting agent is about 1.5 to about 2.5 by weight.

5. like the described oral care composition of aforementioned each claim, the ratio of wherein said sensory agent and sweeting agent is about 1.5 to about 2.5 by weight.

6. like the described oral care composition of aforementioned each claim, wherein said annexing ingredient comprises the combination of flavoring agent and sensory agent.

7. oral care composition as claimed in claim 6, wherein said flavoring agent add that the ratio of sensory agent and sweeting agent is about 0.4 to about 40 by weight.

8. like the described oral care composition of aforementioned each claim, wherein said water insoluble carrier is selected from the group of being made up of following: rubber, native paraffin, synthetic wax, polrvinyl chloride, nylon, fluorocarbon, polyurethane prepolymer, polyethylene, polystyrene, polypropylene, vaseline, polyvinyl acetate, natural oil, artificial oil, fat, silicone, hydrocarbon, caprylic/capric triglyceride, oleic acid, stearic acid and their mixture.

9. like the described oral care composition of aforementioned each claim, wherein said water-msoluble ingredients is selected from the group of being made up of following: microwax, paraffin, Cera Flava, vaseline, mineral oil, polybutene, silicone, natural oil, artificial oil, polyethylene and their combination.

10. like the described oral care composition of aforementioned each claim, wherein said sweeting agent is selected from the group of being made up of following: glucide, sucralose, stevioside, xylitol, aspartame, acesulfame potassium, monoammonium glycyrrhizinate and their mixture.

11. as the described oral care composition of aforementioned each claim, wherein said oral care composition comprises about 50% to about 99% water insoluble carrier and about 0.5% to about 10% sweeting agent.

12. as the described oral care composition of aforementioned each claim, wherein said compositions comprises about by weight 1% to about 10% flavoring agent and about by weight 1% to about 10% sensory agent.

13. like the described oral care composition of aforementioned each claim, wherein said sensory agent is selected from the group of being made up of following: menthol; 3-1-menthoxypropane-1,2-glycol, menthyl lactate; N, 2,3-trimethyl-2-isopropyl butyramide; N-ethyl-right-terpane-3-Methanamide; N-(4-cyano methyl phenyl)-right-menthane carbosamided and their combination.

14. as the described oral care composition of aforementioned each claim; The ratio of wherein said sensory agent and flavoring agent is about 0.5 to about 2.0 by weight; The ratio of said flavoring agent and sweeting agent is about 1.0 to about 4.0 by weight; The ratio of said sensory agent and sweeting agent is about 1.0 to about 4.0 by weight, and said flavoring agent adds that the ratio of sensory agent and sweeting agent is about 2.0 to about 8.0 by weight.

15. oral care composition as claimed in claim 1, wherein said oral care composition is by as the vaseline of said water insoluble carrier, as the glucide of said sweeting agent, form as the Herba Menthae of said flavoring agent with as the menthol of said sensory agent.