CN103957879A - Oral composition - Google Patents
Oral composition Download PDFInfo
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- CN103957879A CN103957879A CN201280058747.1A CN201280058747A CN103957879A CN 103957879 A CN103957879 A CN 103957879A CN 201280058747 A CN201280058747 A CN 201280058747A CN 103957879 A CN103957879 A CN 103957879A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Birds (AREA)
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- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
Provided is an oral composition of exceptional foaming performance and efficacy in maintaining the luster of the tooth surface. An oral composition, characterized by containing: (A) an acylamino acid salt, (B) an alkyl sulfate, (C) a betaine amphoteric surfactant and (D) xanthan gum.
Description
Technical field
The gloss that the present invention relates to a kind of dental surface maintains effect and the excellent composition for oral cavity that bubbles.
Background technology
The brightness that maintains tooth is one of major subjects of stomatologic esthetics.The external painted factor being formed by food pigment etc. by removing the not gentle removal of micro concavo-convex of dental surface, can maintain the brightness of tooth.For the uneven removal of dental surface, although can be undertaken by the mechanism of grinding agent, there is the such problem of hazardness that will reduce soft part in the oral cavities such as gingiva.Therefore, if in view of with the taking into account of use sense,, in the maintaining of tooth brightness, the control of the external painted factors such as color stain removal is important.
For the removal of color stain, can be identical with the uneven removal of the micro concavo-convex of dental surface, to be undertaken by the mechanism of grinding agent, its problem is also same as described above.Up to now, applicant has proposed to use phenoxyethanol etc. not rely on mechanism and has removed the compositions of flank of tooth spot by chemical action in patent documentation 1 (Japanese Patent Laid-Open 2002-47161 communique).In patent documentation 1, as the composition of the phenoxyethanol containing geared surface, lingual surface chemically cleaning base, in embodiment 4, record the aqueous Dentrifice composition that is mixed with N-sodium lauroyl glutamate 0.2 quality %, lauroyl Glycine sodium 0.1 quality %, sodium lauryl sulfate 1.0 quality %, tetrasodium pyrophosphate 4.0 quality % and sodium tripolyphosphate 1.5 quality %.But, although expect that gloss high in this embodiment maintains effect, stimulating by force, use sense also has room for improvement.
In addition, as the use true feeling of composition for oral cavity that improves taste, require to bubble good.Contribute to foaming and gloss to maintain useful composition as brute force, can be anionic surfactant, specifically, acyl amino hydrochlorate, alkyl sulfate as is known.
But although acyl amino hydrochlorate contributes to gloss to maintain effect and bubbles well, when having unique abnormal flavour, its lather quickness, than alkylsurfuric acid salt error, is difficult to obtain satisfied use sense while mixing separately.On the other hand, although that the gloss of alkyl sulfate maintains effect, lather quickness and foaming is good, compared with acylamino acid salt, its existence stimulates strong problem to oral mucosa.
According to more than; although think acyl amino hydrochlorate and alkyl sulfate and with being effective; but in this case, improve effect if increase the combined amount of these two kinds of compositions, have the abnormal flavour of acyl amino hydrochlorate and the such problem of the stimulation of alkyl sulfate.
Prior art document
Patent documentation
Patent documentation 1: Japanese Patent Laid-Open 2002-47161 communique
Summary of the invention
Invent problem to be solved
Thus, in prior art, there is variety of issue as above, be difficult to take into account gloss and maintain the preparation of effect and use sense.Therefore,, in composition for oral cavity, the gloss of taking into account dental surface maintains effect and use sense just becomes a difficult problem.
The present invention is In view of the foregoing and the invention of doing that its object is to provide a kind of gloss of dental surface to maintain effect and the excellent composition for oral cavity that bubbles.
The means of dealing with problems
In order to achieve the above object; the inventor finds through wholwe-hearted result of study; by mixing (A) acyl amino hydrochlorate, (B) alkyl sulfate, (C) betaine type amphoteric surfac-tant and (D) xanthan gum, can obtain the gloss of dental surface maintain effect and bubble good excellent composition for oral cavity.Further find, this composition for oral cavity free from extraneous odour and stimulation, use sense is good.
In the present invention, by by composition (A) and (B) and with and combine and sneak into (C) and (D), the gloss that can take into account the dental surface being caused by chemical action maintains effect and improves foaming effect, particularly, be prepared into dentifrice by toothbrush during for tooth, by chemical action and mechanism, can remove the external painted factors such as the color stain being formed by food pigment etc., and give high gloss and maintain effect.
Therefore, the invention provides following composition for oral cavity.
(1) composition for oral cavity, is characterized in that, contains (A) acyl amino hydrochlorate, (B) alkyl sulfate, (C) betaine type amphoteric surfac-tant and (D) xanthan gum.
(2) composition for oral cavity as described in (1), wherein, (A) acyl amino hydrochlorate is to be selected from more than one in acyl glutamate, acylaspartic acid salt and acylglycine salt.
(3) composition for oral cavity as described in (2), wherein, (A) acyl amino hydrochlorate is acyl glutamate.
(4) composition for oral cavity as described in (1), (2) or (3), wherein, (C) betaine type amphoteric surfac-tant is that fatty acid amide CAB system or alkyl imidazoline betanin are amphoteric surfactant.
(5) composition for oral cavity as described in (4), wherein, (C) betaine type amphoteric surfac-tant is coco-nut oil fatty acid amido propyl betaine.
(6) composition for oral cavity as described in any one in (1)～(5), wherein, composition (A) and combined amount altogether (B) are 0.2～5.5 quality %.
(7) composition for oral cavity as described in (6), wherein, the combined amount of composition (A) is 0.1～2 quality %, the combined amount of composition (B) is 0.1～3.5 quality %.
(8) composition for oral cavity as described in any one in (1)～(7), wherein, contains composition (C) 0.1～1 quality % and composition (D) 0.3～2 quality %.
(9) composition for oral cavity as described in any one in (1)～(8), wherein, is prepared into dentifrice by this composition for oral cavity.
(10) a kind of Dentrifice composition; it is characterized in that, contain (A) be selected from acyl glutamate, acyl group aspartate and acylglycine salt more than one acyl amino hydrochlorate and (B) alkyl sulfate amount to amphoteric surfactant 0.1～1 quality % of 0.2～5.5 quality %, (C) fatty acid amide CAB system or alkyl imidazoline betanin system and (D) xanthan gum 0.3～2 quality %.
Invention effect
The present invention can provide a kind of gloss of dental surface to maintain effect and the excellent composition for oral cavity that bubbles.Further, said preparation free from extraneous odour and stimulation, use sense is good.
Detailed description of the invention
Below, the present invention is discussed in further detail.Composition for oral cavity of the present invention, is characterized in that, contains (A) acyl amino hydrochlorate, (B) alkyl sulfate, (C) betaine type amphoteric surfac-tant and (D) xanthan gum.
As the acyl amino hydrochlorate of composition (A), the carbon number of its acyl group is suitably 8～20, and suitable especially 12～16.In addition, for amino acid group, can enumerate glutamic acid, aspartic acid, glycine, sarcosine, alanine, methionine, phenylalanine, leucine and isoleucine etc., particularly preferably glutamic acid, aspartic acid and glycine, more preferably glutamic acid.For this salt, can enumerate the alkali metal salt such as sodium, potassium, alkali salt and organic amine salt etc.
As acyl amino hydrochlorate; for example; can enumerate the acyl glutamates such as N-lauroyl-Pidolidone sodium, N-myristoyl-Pidolidone sodium, N-coco-nut oil fatty acid acyl group-Monopotassium L-Glutamate; the acylaspartic acid salt such as N-lauroyl-L-Aspartic acid sodium, the acylglycine salt such as N-coco-nut oil fatty acid acylglycine potassium etc.These can be with a kind of or the mode of two or more combinations is mixed.
Specifically, can be called AminoSurfact ALMS-P1 (N-lauroyl-Pidolidone sodium by commodity in use, Asahi Chemical Corp (the ケ ミ カ of Asahi Chemical Industry Le ズ Co., Ltd.)), Amisoft LS-11 (N-lauroyl-Pidolidone sodium, aginomoto healthy supply Co., Ltd. (gourmet powder ヘ ル シ ー サ プ ラ イ Co., Ltd.)), AminoSurfact AMMS-P1 (N-myristoyl-Pidolidone sodium, Asahi Chemical Corp), Amisoft MS-11 (N-myristoyl-Pidolidone sodium, the healthy supply of aginomoto Co., Ltd.), AminoFoamer FLDS-L (N-lauroyl-L-Aspartic acid sodium, Asahi Chemical Corp) and Amilite GCK-12K (N-coco-nut oil fatty acid acylglycine potassium, the healthy supply of aginomoto Co., Ltd.) etc. commercial acyl amino hydrochlorate.
As acyl glutamates such as composition (A), particularly acyl glutamic acid sodium, compared with having the acylamino acid salt of other amino acid residue, its abnormal flavour is little, more suitable aspect use sense.
Maintain the viewpoint of effect and foaming from improving the gloss of tooth, the combined amount of composition (A) is preferably 0.1～2% (quality %, lower with), and more preferably 0.2～2.0%, more preferably 0.2～1.5%.Although combined amount is more, the gloss of tooth maintains effect and bubbles and more improves, if exceed 2%, occurs abnormal flavour, the situation that use sense declines.
As the alkyl sulfate of composition (B), can enumerate the alkali metal salt of the alkylsurfuric acid such as lauryl sulfate, myristyl sulphuric acid, can use separately one or use two or more.As alkyl sulfate, suitable especially employing sodium lauryl sulfate.
For alkyl sulfate, the commercially available prod that can use Toho Chemical Industry Co., Ltd. (JP) Tokyo-To, Japan to manufacture.
The viewpoint that maintains effect and foaming from improving the gloss of tooth, the combined amount of composition (B) is preferably 0.1～3.5%, and more preferably 0.3～2%, more preferably 0.3～1.8%.Although combined amount is more, the gloss of tooth maintains effect and bubbles and more improves, if exceed 3.5%, occurs and stimulates and abnormal flavour, the situation that use sense declines.
In the present invention, composition (A) and composition (B) and use for take into account gloss maintain effect and bubble be important, during not containing composition (A) or while not containing composition (B), gloss maintains effect and foaming is poor, is difficult to reach object of the present invention.
Although contributing to improve gloss, acyl amino hydrochlorate and alkyl sulfate maintain effect and foaming; but particularly acyl amino hydrochlorate aspect abnormal flavour and alkyl sulfate aspect stimulation, have problems; be difficult to this two composition and use; and in the present invention; by using the paralled system of this two composition, can take into account gloss and maintain effect and bubble good.Further, also free from extraneous odour and stimulation, can obtain good use sense.
For composition (A) and (B), if especially balance is well mixed this two composition, at free from extraneous odour with stimulate in the scope of problem, can further improve gloss and maintain effect and foaming, therefore, use preferably.In this case, composition (A) and the combined amount that amounts to (B) can be 0.2～5.5% scope, are preferably 0.7～3%, particularly maintain aspect effect more preferably 0.8～3%, more preferably 0.8～2% at gloss.If composition (A) and combined amount altogether (B) are more than 0.2%, can obtain more excellent gloss as compositions and maintain effect and bubble good.If composition (A) and the combined amount that amounts to (B) exceed 5.5%, there will be abnormal flavour, use sense declines.
As composition (C) betaine type amphoteric surfac-tant, can enumerate the alkyl imidazoline betanins such as fatty acid amide CAB system, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazole quinoline betanin such as alkyl betaine system, the coco-nut oil fatty acid amido propyl betaines such as lauryl dimethyl oxyneurine is amphoteric surfactant, and these can be with separately a kind of or the mode of two or more combinations is mixed.
Specifically, can be called RIKABION A-100 (lauryl dimethyl oxyneurine by commodity in use, New Japan Chem Co., Ltd), TEGO Betain CK OK (coco-nut oil fatty acid amido propyl betaine, Ying Chuan company (EVONIK company)), the commercial betaine type amphoteric surfac-tant such as Enagicol C-40H (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazole quinoline betanin, Lion Corporation).
As composition (C), preferred fatty acid amido propyl betaine system and alkyl imidazoline betanin system, more preferably fatty acid amide CAB is, particularly a little less than the abnormal flavour of coco-nut oil fatty acid amido propyl betaine, suitable use.
Maintain the viewpoint of effect from improving foaming effect and improving gloss, the betaine type amphoteric surfac-tant's of composition (C) combined amount is preferably 0.1～1%, and more preferably 0.4～1%, more preferably 0.4～0.8%.Although combined amount is more, the gloss of tooth maintains effect and bubbles and more improves, if exceed 1%, there will be abnormal flavour, and use sense declines.
In the present invention, by the xanthan gum of composition (D) is mixed jointly with composition (C), making foaming raising effect and gloss maintain effect by composition (A) and paralled system (B) increases, thereby can reach object of the present invention.
The commercial commercially available prod such as xanthan gum Monat Gum DA can commodity in use by name (Si Bikai can company (CP Kelco company)).
The combined amount of composition (D) is preferably 0.3～2%, and more preferably 0.5～2%, more preferably 0.5～1.5%.Although combined amount is more, the gloss of tooth maintains effect and bubbles and more improves, if exceed 2%, has the situation that dispersibility declines and use sense declines of preparation.
Composition for oral cavity of the present invention, is particularly suitable for being prepared into the dentifrices such as toothpaste, aqueous dentifrice, liquid dentifrice, wet-milling dentifrice.In this case, can be as required, in mentioned component, sneak into the corresponding known composition of other dosage form.For example, grinding agent, adhesion agent, binding agent, surfactant be can sneak into, further as required, sweeting agent, antiseptic, coloring agent, spice, various effective ingredient etc. also can be sneaked into.
As grinding agent, can enumerate the silicon dioxide based abrasives such as silica gel, precipitability silicon dioxide, aluminium silicate, the series of calcium phosphate compounds such as dicalcium phosphate dihydrate and anhydride, tricalcium phosphate, tricresyl phosphate magnesium, tetracalcium phosphate, calcium pyrophosphate, calcium carbonate, aluminium hydroxide, aluminium oxide, magnesium carbonate, Zirconium orthosilicate., hydroxyapatite, synthetic resin based abrasive etc.
The combined amount of these grinding agents is generally 0～50% of whole compositions, particularly in toothpaste, can mix 10～50%, in aqueous dentifrice, can mix 0～30%.
As adhesion agent, can enumerate the sugar alcohol such as Sorbitol, xylitol, the polyhydric alcohol such as glycerol, propylene glycol.These combined amount is generally 5～50%, is in particular 20～45%.
As binding agent, except xanthan gum, for example, also can enumerate sodium carboxymethyl cellulose, hydroxyethyl-cellulose, carrageenin, guar gum, sodium alginate, Poise C-80M, tackifying silicon dioxide, Montmorillonitum, gelatin and sodium polyacrylate etc.The combined amount of these binding agents comprises composition (D) and is suitably 0.3～5% interior.
As surfactant, except composition (A), (B) with (C), for example, also can mix the known surfactant such as nonionic surfactant, cationic surfactant.Specifically, as nonionic surfactant, can use sucrose fatty acid ester, fatty ester of maltose, the sugar fatty acid esters such as milk sugar fats acid esters, maltitol fatty acid ester, the sugar alcohol fatty acid esters such as lactose fatty acid ester, polyoxyethylene sorbitan monolaurate, the polyoxyethylene sorbitan fatty acid esters such as polyethenoxy sorbitan monostearate, the polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated Oleum Ricini, lauric acid list or diglycollic amide, fatty acid esters of sorbitan, the senior alcohol ether of polyoxyethylene, poloxalkol, polyoxyethylene polyoxypropylene fatty acid ester etc.As cationic surfactant, can enumerate alkylammonium etc.
In the combined amount of these surfactants, comprise composition (A), (B) and be (C) 1～5% in interior hope scope, particularly 1.5～4% scope.
As sweeting agent, can enumerate saccharin sodium etc.; As antiseptic, can enumerate p-Hydroxybenzoate, sodium benzoate etc.
As coloring agent, can enumerate blue No. 1, yellow No. 4, titanium dioxide etc.
As spice, the known spice material using in composition for oral cavity below use capable of being combined: Oleum menthae, Oleum Menthae Rotundifoliae, Oleum Anisi Stellati, Eucalyptus oil, wintergreen oil, Oleum Cinnamomi, Oleum Caryophylli, thyme oil, sage oil, Fructus Citri Limoniae oil, orange oil, Oleum menthae (Ha ッ カ oil), Cardamom oil, Fructus Coriandri oil, tangerine oil, lime oil, Oleum lavandula angustifolia, oil of rosemary, bay oil, Flos Matricariae chamomillae oil, caraway oil, Majorana hortensis oil, laurel, Indian oil of verbena, Herba Origani oil, pinke needle oil, orange blossom oil, Oleum Rosae Rugosae, Jasmin oil, oil of grapefruit, Sweetie oil (ス ウ ィ ー テ ィ ー oil), grape-fruit seed oil, concrete of iris, Herba Menthae absolute oil, rose absolute, the natural perfume materials such as Orange Blossom, with processed (the front-end volatiles removal to these natural perfume materials, tails is removed, fractional distillation, liquid-liquid extraction, refine, powdered flavour etc.) after spice, and menthol, carvone, anethole, eucalyptole, methyl salicylate, cinnamic aldehyde, acetaminol, 3-L-menthoxypropane-1, 2-glycol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-replacement-to terpane-3-Methanamide, pinene, octanal, citral, pulegone, methyl acetate, anisaldehyde, ethyl acetate, ethyl n-butyrate., allyl cyclohexane propionic ester, methyl 2-aminobenzoate, ethyl methyl phenyl (+)-2,3-Epoxy-1-propanol, vanillin, undecalactone, hexanal, butanols, isoamyl alcohol, hexenol, dimethyl sulfide, methyl cyclopentenyl ketone, bran aldehyde, trimethylpyrazine, ethyl lactate, the single spice such as ethylenebis dithiocarbamate acetas, also have the mediation spice such as strawberry essence, apple essence, flavoring banana essence, flavoring pineapple essence, grape essence, Fructus Mangifera Indicae essence, butter essence, milk flavour, fruit mixing essence, tropical fruit (tree) essence etc.
As various effective ingredient, can enumerate sodium fluoride, the fluorides such as sodium monofluorophosphate, ortho-phosphoric potassium salt, the water-soluble phosphorus acid compounds such as sodium salt, glucanase, become the glucanase such as dextranase, allantoin chlorine hydroxy Al, chamenol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and its esters, sodium chloride, tranexamic acid, episilon amino caproic acid, DL-tocopherol acetate, α-bisabolol, isopropyl methyl phenol, hibitane salt, cetylpyridinium chloride, azulene, enoxolone, sodium copper chlorophllin, the copper compounds such as copper gluconate, aluctyl., strontium chloride, potassium nitrate, berberine, hydroxamic acid and derivant thereof, sodium tripolyphosphate, zeolite, amylase, methoxy-ethylene, copolymer-maleic anhydride, polyvinyl pyrrolidone, epidihydrocholesterol, benzethonium chloride, beta-cholestanol, trichlorocarbanilide, zinc citrate, the soft extract of Radix Angelicae Sinensis, Cortex Phellodendri extract, Flos Caryophylli, Herba Rosmarini Officinalis, Radix Scutellariae, the extracts such as Flos Carthami.In addition, above-mentioned effective ingredient can be not hinder the effective dose in the scope of effect of the present invention to mix.
Embodiment
Below, by enumerating embodiment and comparative example, the present invention is specifically described.But the present invention is not limited to following embodiment.In addition, in following example, if not otherwise specified, % all represents quality %.
[embodiment and comparative example] prepares Dentrifice composition as shown in Tables 1 and 2 by the following method, and evaluates.Result as shown in Tables 1 and 2.
The preparation method of preparation:
The preparation of Dentrifice composition is that the water-soluble substances such as sodium fluoride, D-sorbitol solution is dissolved in after pure water, adds in addition binding agents such as making xanthan gum to be scattered in the liquid of propylene glycol again, stirs and forms.Then, add spice, grinding agent, acyl amino hydrochlorate, sodium lauryl sulfate etc., and under reduced pressure (pressure 4kPa) lower stirring, Dentrifice composition obtained.In manufacture, use 1.5L kneader (manufacture of commercial firm of tor work institute).
Use raw material:
The details of the each composition using in Dentrifice composition preparation is as described below.
(A) N-lauroyl-Pidolidone sodium:
AminoSurfact ALMS-P1 (Asahi Chemical Corp)
(A) N-lauroyl-L-Aspartic acid sodium:
AminoFoamer FLDS-L (Asahi Chemical Corp)
(A) N-coco-nut oil fatty acid-cocos nucifera oil acyl glycine potassium:
Amilite GCK-12K (the healthy supply of aginomoto Co., Ltd.)
(B) sodium lauryl sulfate: Toho Chemical Industry Co., Ltd. (JP) Tokyo-To, Japan manufactures
(C) coco-nut oil fatty acid amido propyl betaine:
TEGO Betain CK OK (30% product, Ying Chuan company)
(C) 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazole quinoline betanin:
Enagicol C-40H (30% product, Lion Corporation)
(D) xanthan gum:
Monat Gum DA (Si Bikai can company)
For other composition, use the material that meets medicine part outer article raw material specification 2006
In addition, as recorded without special, the combined amount of recording in table is purity scaled value.
Evaluation methodology
(1) gloss maintains effect
(1-1) test method
Untreated hydroapatite particles (HAP) surface (HOYA Corp. manufactures, diameter 7mm × thickness 3.5mm), after blasting treatment, cleaned with ultrasonic washing unit in neutral cleaners aqueous solution.After air-dry, use gloss meter (Japanese electricity Se Industrial Co., Ltd manufactures, model: VG2000) to measure glossiness Δ Gs value, and using this value as Δ Gs0.At 50 DEG C, this HAP plate is flooded with the order of 0.5% albumin solution → tannin extracting solution → 0.6% ferric citrate (III) ammonium salt solution, flood 10 minutes at every turn.Tannin extracting solution is prepared by the following method: in the ion exchange water 1200mL of boiling, put into Japanese tea (trade mark: Lao Song) 50g, black tea (Amada Co., Ltd. of Uniliver manufacture, BRISK tea bag (Block リ ス Network テ ィ ー バ ッ Network)) (Amada Co., Ltd. of nest manufactures for 5 bags and instant coffee, trade name Nescafe) 12g, place an evening, filter and remove Japanese tea and black tea.
Repeat again after aforesaid operations 2 times, after cleaning with pure water, at 37 DEG C, this HAP plate be impregnated in the dispersion liquid that cleans the teeth to 3 minutes.The dispersion liquid that cleans the teeth refers to pure water 3 times of the Dentrifice composition dilutions that it is as shown in the table, the supernatant obtaining with 3000rpm centrifugalize 10 minutes.Then, HAP plate is scrubbed.Scrubbing number of times is 100 times, the toothbrush of scrubbing middle use is Clinica4 row microcephaly (Lion Corporation's manufacture), the slurry that cleans the teeth is by 3 times of Dentrifice composition dilutions by pure water, this aqueous solution 30g is added in 100mL Epton (エ プ ト Application) pipe to every 10 seconds up-down vibration 20 times and preparing.For brush machine, use to include in the horizontal brush machine of the V-8 of ISO11609 and can be fixed on the improvement brush machine (manufacture of shop, river, Co., Ltd. palace) of any part for basis and HAP plate.
Scrub HAP plate after treatment after pure water cleans, repeat again 2 times from dipping to a succession of operation of scrubbing processing of albumin solution, after air-dry HAP plate, again measure surperficial Δ Gs, and using Δ Gs after treatment as Δ Gs1.
Calculate gloss according to following formula and maintain effect (%), and evaluate according to following standard.
Gloss maintains effect (%)=100-[(Δ Gs0-Δ Gs1)/Δ Gs0 × 100]
(1-2) gloss maintains the evaluation criterion of effect
◎: more than 70%
Zero: 60% above and be less than 70%
△: more than 50% and be less than 60%
×: be less than 50%
(2) foaming while brushing teeth
(2-1) test method
Adopt 10 experimenters, on toothbrush, glue and get about 1g Dentrifice composition, foaming when carrying out brushing teeth for 3 minutes, obtain (i) bubble very good, (ii) rise and soak, (iii) slightly few and (iv) the bubble answers of few 4 such grades of bubbling.In this answer, the very good meter that will bubble is done 4 points, rises and soaks 3 points, meter work, and slightly few meter that bubbles is done 2 points, and the few meter of foaming is done 1 point, bubbles according to the average mark of 10 and according to following standard evaluation.
(2-2) evaluation criterion of bubbling
◎: more than being equally divided into 3.5 points, below 4.0 points
Zero: be equally divided into 3.0 points above and be less than 3.5 points
△: be equally divided into 2.0 points above and be less than 3.0 points
×: be equally divided into 1.0 points above and be less than 2.0 points
(3) stimulation while brushing teeth
(3-1) test method
Adopt 10 experimenters, stickyly on toothbrush get about 1g Dentrifice composition, the stimulation degree when carrying out brushing teeth for 3 minutes, obtains the answer of 4 grades.In this answer, strongly feel to stimulate meter to do 1 point by (i), (ii) feel to stimulate meter to do 2 points, (iii) almost imperceptible stimulation meter is done 3 points, (iv) imperceptible stimulation meter is done 4 points, according to the average mark of 10 and according to following standard, the zest of oral mucosa is evaluated.
(3-2) evaluation criterion stimulating
◎: more than being equally divided into 3.5 points, below 4.0 points
Zero: be equally divided into 3.0 points above and be less than 3.5 points
△: be equally divided into 2.0 points above and be less than 3.0 points
×: be equally divided into 1.0 points above and be less than 2.0 points
(4) abnormal flavour while brushing teeth
(4-1) test method
Adopt 10 experimenters, on toothbrush, glue and get about 1g Dentrifice composition, brush teeth after approximately 3 minutes, for the abnormal flavour degree of brushing teeth, almost imperceptible abnormal flavour, (iii) feel abnormal flavour and the answer of (iv) feeling 4 grades of strong abnormal flavour a little to obtain (i) complete imperceptible abnormal flavour, (ii).In this answer, complete imperceptible abnormal flavour meter is done to 4 points, almost imperceptible abnormal flavour meter is done 3 points, feels a little 2 points, abnormal flavour meter work, feels 1 point, strong abnormal flavour meter work, according to the average mark of 10 and according to following standard evaluation use sense.
(4-2) evaluation criterion of abnormal flavour
◎: more than being equally divided into 3.5 points, below 4.0 points
Zero: be equally divided into 3.0 points above and be less than 3.5 points
△: be equally divided into 2.0 points above and be less than 3.0 points
×: be equally divided into 1.0 points above and be less than 2.0 points
[table 2]
Claims (10)
1. a composition for oral cavity, is characterized in that, contains (A) acyl amino hydrochlorate, (B) alkyl sulfate, (C) betaine type amphoteric surfac-tant and (D) xanthan gum.
2. composition for oral cavity as claimed in claim 1, wherein, (A) acyl amino hydrochlorate is to be selected from more than one in acyl glutamate, acylaspartic acid salt and acylglycine salt.
3. composition for oral cavity as claimed in claim 2, wherein, (A) acyl amino hydrochlorate is acyl glutamate.
4. the composition for oral cavity as described in claim 1,2 or 3, wherein, (C) betaine type amphoteric surfac-tant is that fatty acid amide CAB system or alkyl imidazoline betanin are amphoteric surfactant.
5. composition for oral cavity as claimed in claim 4, wherein, (C) betaine type amphoteric surfac-tant is coco-nut oil fatty acid amido propyl betaine.
6. the composition for oral cavity as described in any one in claim 1～5, wherein, composition (A) and combined amount altogether (B) are 0.2～5.5 quality %.
7. composition for oral cavity as claimed in claim 6, wherein, the combined amount of composition (A) is 0.1～2 quality %, the combined amount of composition (B) is 0.1～3.5 quality %.
8. the composition for oral cavity as described in any one in claim 1～7, wherein, contains composition (C) 0.1～1 quality % and composition (D) 0.3～2 quality %.
9. the composition for oral cavity as described in any one in claim 1～8, wherein, is prepared into dentifrice by this composition for oral cavity.
10. a Dentrifice composition; it is characterized in that, contain (A) be selected from acyl glutamate, acyl group aspartate and acylglycine salt more than one acyl amino hydrochlorate and (B) alkyl sulfate amount to amphoteric surfactant 0.1～1 quality % of 0.2～5.5 quality %, (C) fatty acid amide CAB system or alkyl imidazoline betanin system and (D) xanthan gum 0.3～2 quality %.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011-261162 | 2011-11-30 | ||
| JP2011261162 | 2011-11-30 | ||
| PCT/JP2012/078839 WO2013080761A1 (en) | 2011-11-30 | 2012-11-07 | Oral composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103957879A true CN103957879A (en) | 2014-07-30 |
| CN103957879B CN103957879B (en) | 2017-08-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280058747.1A Active CN103957879B (en) | 2011-11-30 | 2012-11-07 | Composition for oral cavity |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6060908B2 (en) |
| CN (1) | CN103957879B (en) |
| WO (1) | WO2013080761A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108685742A (en) * | 2017-04-10 | 2018-10-23 | 株式会社爱茉莉太平洋 | Low irritant composition for oral cavity |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY192189A (en) * | 2016-05-30 | 2022-08-05 | Lion Corp | Composition for use in oral cavity |
| JP6715698B2 (en) * | 2016-06-24 | 2020-07-01 | 花王株式会社 | Liquid oral composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007145740A (en) * | 2005-11-25 | 2007-06-14 | Lion Corp | Dentifrice composition |
| JP2008143824A (en) * | 2006-12-08 | 2008-06-26 | Lion Corp | Dentifrice composition |
| JP2010275272A (en) * | 2009-06-01 | 2010-12-09 | Lion Corp | Dentifrice composition |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5467040A (en) * | 1977-11-07 | 1979-05-30 | Lion Corp | Composition for intraoral use |
| JPS6092208A (en) * | 1983-10-25 | 1985-05-23 | Kao Corp | Dentifrice composition containing sodium chloride |
| JPH0912438A (en) * | 1995-06-28 | 1997-01-14 | Lion Corp | Composition for oral cavity |
| JP4109727B2 (en) * | 1996-07-05 | 2008-07-02 | サンスター株式会社 | Composition for oral cavity containing amino acid surfactant |
-
2012
- 2012-11-07 JP JP2013547078A patent/JP6060908B2/en active Active
- 2012-11-07 WO PCT/JP2012/078839 patent/WO2013080761A1/en active Application Filing
- 2012-11-07 CN CN201280058747.1A patent/CN103957879B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007145740A (en) * | 2005-11-25 | 2007-06-14 | Lion Corp | Dentifrice composition |
| JP2008143824A (en) * | 2006-12-08 | 2008-06-26 | Lion Corp | Dentifrice composition |
| JP2010275272A (en) * | 2009-06-01 | 2010-12-09 | Lion Corp | Dentifrice composition |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108685742A (en) * | 2017-04-10 | 2018-10-23 | 株式会社爱茉莉太平洋 | Low irritant composition for oral cavity |
| CN108685742B (en) * | 2017-04-10 | 2022-11-04 | 株式会社爱茉莉太平洋 | Low irritation oral compositions |
| TWI817943B (en) * | 2017-04-10 | 2023-10-11 | 南韓商愛茉莉太平洋股份有限公司 | Low irritating oral composition |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6060908B2 (en) | 2017-01-18 |
| WO2013080761A1 (en) | 2013-06-06 |
| JPWO2013080761A1 (en) | 2015-04-27 |
| CN103957879B (en) | 2017-08-08 |
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