CN108685742B - Low irritation oral compositions - Google Patents
Low irritation oral compositions Download PDFInfo
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- CN108685742B CN108685742B CN201810310276.8A CN201810310276A CN108685742B CN 108685742 B CN108685742 B CN 108685742B CN 201810310276 A CN201810310276 A CN 201810310276A CN 108685742 B CN108685742 B CN 108685742B
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- Prior art keywords
- glutamate
- surfactant
- based surfactant
- irritation
- low
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Abstract
The present invention relates to a low-irritant oral composition, and more particularly to a high-bubble, low-irritant oral composition containing a glutamate-based surfactant and an amidopropyl betaine-based surfactant, which hardly irritates the oral mucosa, is excellent in bubble generation performance during use, is less bitter and unpleasant, and is excellent in use feeling.
Description
Technical Field
The present invention relates to a low-irritation oral composition, and more particularly to an oral composition containing a glutamate-based surfactant and an amidopropyl betaine-based surfactant, which has excellent foam-generating ability when used, hardly irritates the oral mucosa, reduces bitterness and unpleasant taste, and remarkably improves feeling and preference in use.
Background
Sodium lauryl sulfate is used as a foaming agent in various forms of oral compositions. Sodium lauryl sulfate is widely used as a foaming agent because of its advantages of low bitterness and abundant air bubbles unlike other anionic surfactants, and is also known to be a component that stimulates and induces inflammation.
As described above, anionic surfactants including sodium lauryl sulfate generally have a problem of strong irritativeness. Therefore, in order to improve both the detergency and the foaming property while alleviating the strong irritation, an amphoteric surfactant is used together in some of the known techniques. It is known that such amphoteric surfactants have less irritation than anionic surfactants, and when used in combination with anionic surfactants, the cationic nature of the surfactants makes the bubble film stronger, and improves the stability of the bubbles. However, most amphoteric surfactants have a limited amount of use because they exhibit strong bitterness and unpleasant taste.
Documents of the prior art
(patent document 001) Korean laid-open patent publication No. 10-2016-0090708
(patent document 002) Korean laid-open patent publication No. 10-2014-0007406
Disclosure of Invention
To solve the technical problem
The present invention provides a high-bubble, low-irritation oral composition which hardly causes irritation to the oral mucosa by containing a glutamate-based surfactant and an amidopropyl betaine-based surfactant, has excellent bubble generation performance in use, has a low bitter taste and unpleasant taste, and has an excellent feeling in use.
Means for solving the problems
In order to achieve the above object, the present invention provides a low-irritation oral composition characterized by containing a glutamate-based surfactant and an amidopropyl betaine-based surfactant.
Effects of the invention
The low-irritation oral composition according to the present invention contains a glutamate-based surfactant and an amidopropyl betaine-based surfactant, and has excellent bubble generation ability when used, little irritation to the oral mucosa, little bitterness and unpleasant taste, and excellent feeling in use.
Detailed Description
The low-irritation oral composition of the present invention will be specifically described below.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Generally, the nomenclature used in this specification is those well known and conventional in the art.
The low-irritation oral composition of the present invention may contain a glutamate-based surfactant and an amidopropyl betaine-based surfactant.
The Glutamate surfactant may be Sodium Lauroyl Glutamate (Sodium Lauroyl Glutamate), and the amidopropyl Betaine surfactant may be Lauramidopropyl Betaine (lauramidodopropyBetaine).
At this time, in order to achieve the objective effect, the ratio of the glutamate-based surfactant to the amidopropyl betaine-based surfactant may be set to 1 to 3:1, preferably in a weight ratio of 1.5 to 2:1, were mixed.
In addition, in order to achieve the target effect, the content of the glutamate-based surfactant and the amidopropyl betaine-based surfactant may be 0.5 to 2.5 wt% based on the total weight of the composition, and preferably, the content of the glutamate-based surfactant and the amidopropyl betaine-based surfactant is 1.0 to 2.0 wt%.
When the content of the glutamate-based surfactant and the amidopropyl betaine-based surfactant is less than 0.5 wt%, the amount of bubble formation is small when used, and when it exceeds 2.5 wt%, the feeling of use is reduced due to bitterness.
In one aspect, the low-irritation oral composition of the present invention may further contain arginine in order to promote bubble formation.
At this time, in order to achieve the objective effect, the arginine may be contained in an amount of 0.1 to 10% by weight, based on the total weight of the composition. When the content of arginine is less than 0.1% by weight, the bubble-increasing effect is low, and when it exceeds 10% by weight, it is difficult to form a dosage form, so that it is not suggested.
The dosage form of the low-irritation oral composition of the present invention is not particularly limited, and may be specifically a dosage form such as toothpaste, an oral cavity refreshing agent, a tooth whitening agent, and the like.
The low-irritating oral composition of the present invention may contain conventional abrasives, humectants, auxiliary foaming agents, binders, sweeteners, pH regulators, preservatives, medicinal ingredients, flavors, whitening agents, pigments, solvents, etc., depending on the dosage form and the intended use.
The abrasive may be calcium carbonate, precipitated silica, aluminum hydroxide, dipotassium hydrogen phosphate, insoluble sodium metaphosphate, etc., and these abrasives are mixed singly or 2 or more and used in an amount of 1 to 60% by weight based on the total weight of the composition.
The humectant may be glycerin, sorbitol solution, polyethylene glycol, propylene glycol, etc., and these humectants are used alone or in combination of 2 or more and in an amount of 1 to 80% by weight based on the total weight of the composition.
The auxiliary foaming agent may be used in an amount of 0.1 to 10 wt% based on the total weight of the composition by mixing an anionic surfactant such as a sulfate, a sulfosuccinate, a sarcosinate, a phosphoric acid, a isethionate, a taurate or the like, an amphoteric surfactant such as a sulfobetaine or an amphoteric acetate, a polyoxyethylene sorbitan fatty acid ester, a polyethylene glycol (hydrogenated) castor oil, a glycerin fatty acid ester, a sorbitan fatty acid ester, a sucrose fatty acid ester, an alkylolamide, an alkylglucoside or the like, a nonionic surfactant such as N-alkyldiaminoethylglycine or the like, or 2 or more cationic surfactants.
The binder may be sodium carboxymethylcellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, xanthan gum, carrageenan, sodium alginate, etc. in an amount of 0.1-10 wt% based on the total weight of the composition, by mixing singly or 2 kinds thereof.
The sweetener may be saccharin sodium, aspartame, stevioside, xylitol, glycyrrhizic acid, etc. singly or in combination of 2 or more and used in an amount of 0.001-1 wt% based on the total weight of the composition.
The pH regulator can be sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium pyrophosphate, citric acid, sodium citrate, tartaric acid, etc. or mixture of 2 or more thereof; the antiseptic can be methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, sodium benzoate, etc., or mixture of more than 2 kinds thereof.
The effective components can be sodium fluoride, sodium monofluorophosphate, tin fluoride, chlorhexidine, allantoin chlorohydroxyaluminate (alantoin chlorohydroxy aluminate), aminocaproic acid, triclosan, cetyl pyridinium chloride, zinc chloride, pyridoxine hydrochloride, and vitamin E acetate, or mixture of 2 or more thereof.
The perfume may be peppermint oil, spearmint oil, menthol, anethole, etc. or mixture of 2 or more kinds thereof, whitening agent may be titanium oxide, pigment may be edible pigment, and solvent may be refined water or ethanol.
The additives as described above may be prepared according to a general toothpaste preparation method by adding various components and contents according to purposes and conditions.
The present invention will be described in more detail with reference to examples and test examples. However, these examples and test examples are only for understanding the present invention and are not intended to limit the scope of the present invention, and modifications, substitutions, and insertions known in the art are also considered to be included in the scope of the present invention.
< preparation example > preparation of toothpaste
Examples 1 and 2 and comparative examples 1 to 4 were prepared according to the compositions shown in the following table 1, the units shown in the following table 1 being weight% of the respective ingredients based on the total weight of the composition.
TABLE 1
< test example 1> evaluation test of foaming ability
The foaming power of a toothpaste using a glutamate surfactant and an amidopropyl betaine surfactant was evaluated, 5g of each of the toothpaste compositions of examples 1 and 2 and comparative examples 1 to 4 in table 1 were weighed in a beaker, 45g of purified water was added to make 50g of the total amount, the mixture was put in a 250ml measuring cylinder, the opening of the cylinder was closed, and the foaming power was measured in a state of rotating at 180 degrees for 8 times, and the measurement was repeated 3 times. The measurement was carried out on a scale of 250ml, and the number corresponding to the height at which bubbles were formed from 0 was recorded in ml. The measurement results are shown in table 2 below.
TABLE 2
| Example 1 | Example 2 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | |
| 1 time of | 186.1 | 193.6 | 180.6 | 177.5 | 182.5 | 180.9 |
| 2 times (one time) | 185.8 | 192.2 | 178.9 | 178.8 | 183.6 | 179.6 |
| 3 times of | 187.2 | 194.8 | 179.8 | 179.6 | 182.4 | 182.7 |
| Average | 186.4 | 193.5 | 179.8 | 178.6 | 182.8 | 181.1 |
From the results of table 2 above, it is understood that example 1 including sodium lauroyl glutamate as a glutamate-based surfactant and lauramidopropyl betaine as an amidopropyl betaine-based surfactant and example 2 further including arginine are more excellent in foaming ability than comparative examples 1, 2 containing only sodium lauroyl glutamate or lauramidopropyl betaine alone.
It is also known that the foaming ability of examples 1 and 2 is also more excellent than that of comparative example 3 using sodium lauryl sulfate and comparative example 4 containing sodium cocoyl glutamate and cocamidopropyl dimethyl glycine solution which are generally contained in products not using sodium lauryl sulfate.
Thus, it was found that the foaming ability was more excellent when the foaming agent contained sodium lauroyl glutamate and lauramidopropyl betaine together or arginine in addition thereto, as compared with comparative examples 1 to 4 in which the above-mentioned components were used alone or the conventional foaming agent generally used was contained.
< test example 2> evaluation test for irritation to oral mucosa
In order to evaluate the irritation to the oral mucosa when a glutamate-based surfactant and an amidopropyl betaine-based surfactant were used together, 20 subjects sensitive to mucosal irritation were used as test subjects, and 1g each of the toothpaste compositions of examples 1 and 2 and comparative examples 1 to 4 was applied to a toothbrush, and the irritation to the oral mucosa was evaluated for 3 minutes by brushing the teeth. Depending on the degree of stimulation, the oral mucosa was evaluated for irritation by an average of 20 persons, in which "no irritation was felt", "little irritation was felt", "2", "3", "strong irritation was felt" and "4". The evaluation results are shown in table 3 below.
TABLE 3
As can be seen from the results of table 3 above, the toothpaste prepared by comparative example 3 containing sodium lauryl sulfate showed greater irritation to the oral mucosa compared to examples 1 and 2 and comparative examples 1, 2 and 4, and examples 1 and 2 of the present invention showed less irritation to the oral mucosa compared to comparative examples 1 to 4 using sodium lauroyl glutamate or lauramidopropyl betaine alone or containing a conventional foaming agent generally used.
< test example 3> evaluation test of bitterness and unpleasant taste
In order to evaluate the feeling of use when a glutamate-based surfactant and an amidopropyl betaine-based surfactant were used together, 1g each of the toothpaste compositions of examples 1 and 2 and comparative examples 1 to 4 was applied to a toothbrush, and after brushing for 3 minutes, the bitterness and unpleasant taste were evaluated, with 20 flavor examiners as test subjects. The bitterness and unpleasant taste were evaluated by a standard 5-point method (5 points: very strong, 4 points: strong, 3 points: normal, 2 points: weak, 1 point: very weak) according to the degree of bitterness and unpleasant taste, respectively, and the bitterness and unpleasant taste were evaluated by an average value of 20. The evaluation results are shown in table 4 below.
TABLE 4
As can be seen from the results of table 4 above, the toothpaste compositions of examples 1, 2 of the invention of the present application had a much lower degree of bitterness and unpleasant taste than comparative examples 1-4, particularly comparative example 4 containing sodium cocoyl glutamate and cocamidopropyl dimethyl glycine solution.
As described above, the low-irritant oral composition of the present invention comprises a glutamate-based surfactant and an amidopropyl betaine-based surfactant, has excellent bubble generation ability, causes very little irritation to the oral mucosa, has reduced bitterness and unpleasant taste, and has excellent sensation upon use.
Claims (3)
1. A low-irritation oral composition comprising a glutamate-based surfactant, an amidopropyl betaine-based surfactant, and arginine, and being free of a sulfate-based surfactant;
wherein the glutamate surfactant is sodium lauroyl glutamate;
the amidopropyl betaine surfactant is lauramidopropyl betaine;
on the basis of weight, the mixing ratio of the glutamate surfactant to the amidopropyl betaine surfactant is 1-3:1.
2. the low irritation oral composition of claim 1 wherein said glutamate-based surfactant and said amidopropyl betaine-based surfactant are present in an amount of from 0.5 to 2.5 weight percent, based on the total weight of the composition.
3. The low irritation oral composition of claim 1 wherein said arginine is present in an amount of from 0.1 to 10 weight percent based on the total weight of the composition.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020170045938A KR102337307B1 (en) | 2017-04-10 | 2017-04-10 | Low irritating oral composition |
| KR10-2017-0045938 | 2017-04-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108685742A CN108685742A (en) | 2018-10-23 |
| CN108685742B true CN108685742B (en) | 2022-11-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810310276.8A Active CN108685742B (en) | 2017-04-10 | 2018-04-09 | Low irritation oral compositions |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR102337307B1 (en) |
| CN (1) | CN108685742B (en) |
| TW (1) | TWI817943B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1074247A2 (en) * | 1999-07-20 | 2001-02-07 | Zschimmer & Schwarz Italiana S.p.A. | Cleansing or cosmetic compositions comprising zinc alkylsulphates and/or alky(poly)ethoxysulphates as surfactants and preservatives |
| CN101563064A (en) * | 2006-11-14 | 2009-10-21 | 新时代株式会社 | Oral composition containing crystalline cellulose surface-treated with water-soluble substance |
| CN101938983A (en) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | Oral care product and methods of use thereof |
| CN103957879A (en) * | 2011-11-30 | 2014-07-30 | 狮王株式会社 | Oral composition |
| CN104822360A (en) * | 2012-12-06 | 2015-08-05 | 高露洁-棕榄公司 | Surfactant systems for zinc containing compositions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5853387B2 (en) | 2011-03-25 | 2016-02-09 | ライオン株式会社 | Liquid oral composition and method for stabilizing and blending ingredients into the composition |
| KR101723588B1 (en) | 2015-01-22 | 2017-04-06 | 조선대학교산학협력단 | Composition for mouth comprising camellia japonica l leaf extract and manufacturing method thereof |
-
2017
- 2017-04-10 KR KR1020170045938A patent/KR102337307B1/en active IP Right Grant
-
2018
- 2018-04-09 CN CN201810310276.8A patent/CN108685742B/en active Active
- 2018-04-10 TW TW107112283A patent/TWI817943B/en active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1074247A2 (en) * | 1999-07-20 | 2001-02-07 | Zschimmer & Schwarz Italiana S.p.A. | Cleansing or cosmetic compositions comprising zinc alkylsulphates and/or alky(poly)ethoxysulphates as surfactants and preservatives |
| CN101563064A (en) * | 2006-11-14 | 2009-10-21 | 新时代株式会社 | Oral composition containing crystalline cellulose surface-treated with water-soluble substance |
| CN101938983A (en) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | Oral care product and methods of use thereof |
| CN103957879A (en) * | 2011-11-30 | 2014-07-30 | 狮王株式会社 | Oral composition |
| CN104822360A (en) * | 2012-12-06 | 2015-08-05 | 高露洁-棕榄公司 | Surfactant systems for zinc containing compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108685742A (en) | 2018-10-23 |
| KR102337307B1 (en) | 2021-12-09 |
| KR20180114338A (en) | 2018-10-18 |
| TWI817943B (en) | 2023-10-11 |
| TW201836585A (en) | 2018-10-16 |
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