TW201836585A - Low irritating oral composition capable of achieving excellent bubble generation performance during application and having little bitterness and unpleasant taste to achieve excellent sense of use - Google Patents

Abstract

The present invention relates to a low irritating oral composition, which is substantially a high-bubble and low-irritating oral composition containing glutamate surfactant and amidopropyl betaine surfactant. The oral composition may hardly irritate oral mucosa, and may have excellent bubble generation performance during application and only have little bitterness and unpleasant taste to achieve excellent sense of use.

Description

Low irritation oral composition

The invention relates to a low-irritation oral composition, in particular to an oral composition containing a glutamate surfactant and an aminopropyl betaine surfactant, and the composition has excellent foam generation ability when used. It has almost no irritation to the oral mucosa, reduces bitterness and unpleasant taste, and significantly improves the use and preference.

Sodium lauryl sulfate is used as a foaming agent in various oral compositions. Different from other anionic surfactants, sodium lauryl sulfate is widely used as a foaming agent because of its advantages of small bitterness and rich bubbles, and it is also a known ingredient that stimulates and induces inflammation.

As described above, anionic surfactants including sodium lauryl sulfate generally have a problem of strong irritation. Therefore, in order to alleviate the strong irritation and improve the washing characteristics and the foaming characteristics, amphoteric surfactants are used together in some known techniques. It is known that such amphoteric surfactants have lower stimulation than anionic surfactants. When used in combination with anionic surfactants, the cationic properties of the surfactants make the bubble film stronger and improve the stability of the bubbles. However, since most of the amphoteric surfactants exhibit strong bitterness and unpleasant taste, their use amount is limited.

Prior art literature

(Patent Document 001) Korean Patent Publication Gazette No. 10-2016-0090708

(Patent Document 002) Korean Patent Publication No. 10-2014-0007406

To solve technical problems

The present invention provides a high-bubble, low-irritant oral composition. The composition contains glutamate surfactants and amidopropyl betaine surfactants, which has little irritation to the oral mucosa. It is excellent in production performance, has a small bitterness and unpleasant taste, and has excellent use feeling.

Problem solving

In order to achieve the above object, a low-irritation oral composition according to a feature of the present invention is characterized in that the composition contains a glutamate-based surfactant and a propylaminobetaine-based surfactant.

Invention effect

The low-irritation oral composition according to the present invention contains a glutamate surfactant and an aminopropyl betaine surfactant, and when used, not only has a very excellent bubble generation ability, but also has little irritation to the oral mucosa The bitterness and unpleasant taste are small, and the use feeling is excellent.

Hereinafter, the low-irritation oral composition of this invention is demonstrated concretely.

Without other definitions, all technical and scientific terms used in this specification are the same as those commonly understood by those skilled in the art. In general, the nomenclature used in this specification is well known and customary in the art.

The low-irritation oral composition of the present invention may be composed of a glutamate-based surfactant and an aminopropylbetaine-based surfactant.

As the glutamate surfactant, sodium lauroyl glutamate may be used, and as the amidopropyl betaine surfactant, Lauramidopropyl Betaine may be used.

At this time, in order to achieve the target effect, the glutamate surfactant and the amidopropyl betaine surfactant may be mixed in a weight ratio of 1-3: 1, preferably 1.5- Mix at a weight ratio of 2: 1.

In addition, in order to achieve the target effect, based on the total weight of the composition, the content of the glutamate surfactant and amidopropyl betaine surfactant may be 0.5-2.5% by weight, preferably, The content of the glutamate surfactant and the amidopropyl betaine surfactant is 1.0-2.0% by weight.

When the content of the glutamate surfactant and amidopropyl betaine surfactant is less than 0.5% by weight, the amount of bubble generation will be small when used, and when it exceeds 2.5% by weight, it will be reduced due to bitterness Usability.

In one aspect, the low-irritation oral composition of the present invention may further contain arginine in order to promote bubble generation.

At this time, in order to achieve the target effect, the content of the arginine may be 0.1-10% by weight based on the total weight of the composition. When the content of the arginine is less than 0.1% by weight, the effect of increasing bubbles is low, and when it exceeds 10% by weight, it is difficult to formulate it, so it is not recommended.

The dosage form of the low-irritation oral composition of the present invention is not particularly limited, and may specifically be a dosage form such as a toothpaste, an oral cooling agent, or a tooth whitening agent.

In addition, the low-irritation oral composition of the present invention may contain commonly used abrasives, humectants, auxiliary foaming agents, adhesives, sweeteners, pH adjusters, preservatives, and medicinal effects depending on the formulation and purpose Ingredients, fragrances, brighteners, pigments, solvents, etc.

The abrasive may be calcium carbonate, precipitated silica, aluminum hydroxide, dipotassium hydrogen phosphate, and insoluble sodium metaphosphate, etc. These abrasives may be used alone or in combination of two or more kinds and used based on the total weight of the composition. Amount from 1 to 60% by weight.

The wetting agent may be glycerin, sorbitol liquid, polyethylene glycol, propylene glycol, or the like, and these wetting agents are mixed alone or in combination of two or more and used in an amount of 1 to 80% by weight based on the total weight of the composition.

The auxiliary foaming agent may be an anionic surfactant, an amphoteric surfactant, a nonionic surfactant, or a cationic surfactant alone or in combination of two or more, and based on the total weight of the composition, 0.1- An amount of 10% by weight, wherein the anionic surfactants are sulfates, sulfosuccinates, sarcosinates, phosphates, isethionates, taurates, etc., The amphoteric surfactant is sulfobetaine, amphoteric acetate, etc., and the nonionic surfactant is polyoxyethylene sorbitan fatty acid ester, polyethylene glycol (hydrogenated) castor oil, glycerin fat Acid esters, sorbitan fatty acid esters, sucrose fatty acid esters, alkyl alcohol amides, alkyl glucosides, and the like, and the cationic surfactant is N-alkyldiaminoethylglycine and the like.

The binder may be a mixture of carboxymethylcellulose sodium, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, xanthan gum, carrageenan, sodium alginate and the like alone and in combination. The total weight of the composition is used in an amount of 0.1 to 10% by weight based on the total amount.

The sweetener may be a mixture of saccharin sodium, aspartame, stevia, xylitol, glycyrrhizic acid, etc. alone or in combination of two or more kinds, and the amount is 0.001-1 wt% based on the total weight of the composition. .

The pH adjusting agent may be sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium phosphate, sodium pyrophosphate, citric acid, sodium citrate, tartaric acid, etc. alone or in combination of two or more; the preservative may be Methyl hydroxybenzoate, propyl parahydroxybenzoate, sodium benzoate, and the like are used alone or in combination.

The medicinal ingredient may be sodium fluoride, sodium monofluorophosphate, tin fluoride, chlorhexidine, allantoin chlorohydroxyaluminate, aminocaproic acid, triclosan, cetyl Pyridine chloride, zinc chloride, pyridoxine hydrochloride, vitamin E acetate and the like are used alone or in combination of two or more.

The spice may be peppermint oil, spearmint oil, menthol, anise brain, etc., alone or in combination, and used in an appropriate amount. The whitening agent may be titanium oxide, the pigment may be edible pigment, and the solvent may be used. Refined water or ethanol.

The above-mentioned additives can be prepared according to a common toothpaste preparation method by adding different components and contents according to the purpose and conditions.

Hereinafter, the content of the present invention will be described in more detail through examples and test examples. However, these examples and test examples are only used to understand the content of the present invention and are not used to limit the protection scope of the present invention. Modifications, substitutions, and insertions known in the art should also be considered to be included in the scope of the present invention. . <Preparation example> Preparation of toothpaste

Examples 1 and 2 and Comparative Examples 1-4 were prepared according to the compositions in Table 1 below. The units in Table 1 below are based on the weight percentage of the corresponding ingredients based on the total weight of the composition. Table 1 ＜ Test example 1 ＞ Foaming ability evaluation test

To evaluate the foaming power of toothpastes using both glutamate surfactants and amidopropyl betaine surfactants, take the toothpastes of Examples 1, 2 and Comparative Examples 1-4 in Table 1 above. 5g each of the composition was weighed in a beaker, 45g of purified water was added to make the total amount to 50g, and each was added to a 250ml graduated cylinder, the bottle mouth was blocked, and the foaming power was measured in a state after each rotation of 180 degrees, The measurement was repeated 3 times. The measurement is observed from a 250ml scale, and the digits corresponding to the height of bubble generation from 0 are recorded, and the unit is ml. The measurement results are shown in Table 2 below. Table 2

From the results in Table 2 above, it can be seen that, compared with Comparative Examples 1 and 2 containing only sodium lauryl glutamate or laurylamine propyl betaine alone, laurel as a glutamate surfactant is included. Example 1 of sodium glutamate and lauronium propyl betaine which is a guanamine propyl betaine-based surfactant and Example 2 which also contains arginine are more excellent in foaming ability.

It can also be seen that compared to Comparative Example 3 using sodium lauryl sulfate and sodium cocoyl glutamate and cocamidopropyldiamine which are generally contained in products that do not use sodium lauryl sulfate In Comparative Example 4 of the methylglycine solution, the foaming ability of Examples 1 and 2 was also superior.

Therefore, it can be seen that, compared with Comparative Examples 1-4 in which the above-mentioned ingredients are used alone or in which a conventionally used foaming agent is contained, sodium lauryl glutamate and laurylamine propyl betaine are also contained or in addition to this In the case of arginine, its foaming ability is more excellent. ＜ Test example 2 ＞ Evaluation test of oral mucosa irritation

In order to evaluate the irritation of the oral mucosa when glutamate surfactants and amidopropyl betaine surfactants were used together, 20 subjects who were sensitive to mucosal irritation were used as test objects, and they were collected on a toothbrush. Each of the toothpaste compositions of Examples 1 and 2 and Comparative Examples 1-4 described above was 1 g, and the teeth were brushed for 3 minutes to evaluate the irritation of the oral mucosa. Depending on the level of irritation, a score of "no stimulus was felt" was recorded, a score of "very little stimulus was felt" was recorded as 2 points, a score of "sensation stimulated" was recorded as 3 points, and a score of "stimulated stimulus" was recorded as 4 Points, and the irritation to the oral mucosa was evaluated by an average of 20 persons. The evaluation results are shown in Table 3 below. table 3

From the results in Table 3 above, it can be seen that compared to Examples 1, 2 and Comparative Examples 1, 2 and 4, the toothpaste prepared from Comparative Example 3 containing sodium lauryl sulfate exhibited greater oral mucosa. Compared with the comparative examples 1-4 using sodium lauryl glutamate or laurylamine propyl betaine alone, or containing existing commonly used foaming agents, Examples 1 and 2 of the present invention Less irritating to oral mucosa. <Test Example 3> Evaluation test of bitterness and unpleasant taste

In order to evaluate the sensation of using glutamate surfactant and amidopropyl betaine surfactant at the same time, 20 fragrance reviewers were used as test objects, and the above-mentioned Examples 1, 2 and Each of the toothpaste compositions of Comparative Examples 1-4 was 1 g, and after 3 minutes of brushing, the bitterness and unpleasant taste were evaluated. According to the degree of bitterness and unpleasant taste, a 5-point standard method (5 points: very strong, 4 points: strong, 3 points: normal, 2 points: weak, 1 point: very weak) was evaluated separately, with 20 The average value of the names evaluates bitterness and unpleasant taste. The evaluation results are shown in Table 4 below. Table 4

From the results in Table 4 above, it can be seen that the degree of bitterness and unpleasant taste of the toothpaste composition of Examples 1 and 2 of the invention of the present application is much lower than those of Comparative Examples 1-4, especially containing coco-glutamic acid Comparative Example of Sodium and Cocamidopropyl Diglycine Solution 4.

As described above, the low-irritation oral composition of the present invention contains a glutamate-based surfactant and an aminopropylbetaine-based surfactant, which have excellent bubble generation ability and irritating the oral mucosa. Low, reducing bitterness and unpleasant taste, and excellent use feeling.

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Claims (7)

A low-irritation oral composition, characterized in that the composition contains a glutamate-based surfactant and an aminopropylbetaine-based surfactant. The low-irritation oral composition according to item 1 of the scope of the patent application, wherein the glutamate surfactant is sodium lauryl glutamate. The low-irritation oral composition according to item 1 of the scope of the patent application, wherein the amidopropyl betaine surfactant is lauramine aminopropyl betaine. The low irritation oral composition according to item 1 of the scope of the patent application, wherein the mixing ratio of the glutamate surfactant and the amidopropyl betaine surfactant is based on weight as 1-3: 1. The low-irritation oral composition according to item 1 of the scope of the patent application, wherein, based on the total weight of the composition, the glutamate surfactant and the amidopropyl betaine surfactant are The content is 0.5-2.5% by weight. The low-irritation oral composition according to item 1 of the patent application scope, wherein the composition further contains arginine. The low-irritation oral composition according to item 6 of the scope of patent application, wherein the content of the arginine is 0.1-10% by weight based on the total weight of the composition.