KR102337307B1 - Low irritating oral composition - Google Patents

Abstract

The present invention relates to a composition for hypoallergenic oral use, and more specifically, by including a glutamate-based surfactant and an amidopropyl betaine-based surfactant, there is little irritation to the oral mucosa, and very good bubble generation when used, The present invention relates to a high foaming hypoallergenic composition for oral cavity with excellent feeling of use due to less bitter taste and unpleasant taste.

Description

Hypoallergenic oral composition {LOW IRRITATING ORAL COMPOSITION}

The present invention relates to a hypoallergenic composition for oral use, and more specifically, it contains a glutamate-based surfactant and an amidopropyl betaine-based surfactant, and has excellent foaming when used with little irritation to the oral mucosa, bitter taste and It relates to a composition for oral use that significantly improves the feeling of use and preference by reducing unpleasant taste.

Sodium lauryl sulfate is used as a foaming agent in various types of oral compositions. Sodium lauryl sulfate, unlike other anionic surfactants, is often used as a foaming agent due to its advantages of low bitterness and abundant bubbles, but it is known as an irritant and inflammation-inducing component.

As such, anionic surfactants including sodium lauryl sulfate generally have a problem in that they have strong irritation. Therefore, in order to alleviate strong irritation and at the same time improve cleaning properties and foaming properties, some techniques are known for using an amphoteric surfactant together. It is known that these amphoteric surfactants are less irritating than anionic surfactants, and when used in combination with anionic surfactants, the cationic properties in the surfactant make the bubble membrane harder, thereby increasing bubble stability. However, most amphoteric surfactants have a limitation in that their usage is limited because they strongly produce bitter and unpleasant taste.

Republic of Korea Patent Publication No. 10-2016-0090708 Republic of Korea Patent Publication No. 10-2014-0007406

The present invention contains a glutamate-based surfactant and an amidopropyl betaine-based surfactant, so there is almost no irritation to the oral mucosa, excellent bubble generation when used, and excellent feeling of use due to low bitterness and unpleasant taste An object of the present invention is to provide a composition for polar oral use.

The composition for hypoallergenic oral cavity according to a feature of the present invention for achieving the above object is characterized in that it contains a glutamate-based surfactant and an amidopropyl betaine-based surfactant.

The hypoallergenic composition for oral use according to the present invention, including a glutamate-based surfactant and an amidopropyl betaine-based surfactant, has very excellent bubble generation when used, and almost no irritation to the oral mucosa, and has a bitter and unpleasant taste. It is small and the feeling of use is excellent.

Hereinafter, the composition for hypoallergenic oral cavity according to the present invention will be described in detail.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In general, the nomenclature used herein is those well known and commonly used in the art.

The composition for hypoallergenic oral use according to the present invention may include a glutamate-based surfactant and an amidopropyl betaine-based surfactant.

The glutamate-based surfactant may be sodium lauroyl glutamate (Sodium Lauroyl Glutamate), and the amidopropyl betaine-based surfactant may be lauramidopropyl betaine (Lauramidopropyl Betaine).

In this case, the glutamate-based surfactant and the amidopropyl betaine-based surfactant may be mixed in a weight ratio of 1 to 3:1, preferably in a weight ratio of 1.5 to 2:1, for the desired effect. .

In addition, the glutamate-based surfactant and amidopropyl betaine-based surfactant may be included in an amount of 0.5 to 2.5% by weight based on the total weight of the composition for the desired effect, preferably in an amount of 1.0 to 2.0% by weight may be included.

If the content of the glutamate-based surfactant and the amidopropyl betaine-based surfactant is less than 0.5% by weight, the amount of bubbles generated during use may be small, and if it exceeds 2.5% by weight, the feeling of use may be deteriorated due to the bitter taste.

On the other hand, the composition for hypoallergenic oral cavity according to the present invention may further include arginine in order to further promote bubble formation.

In this case, the arginine may be included in an amount of 0.1 to 10% by weight based on the total weight of the composition for the desired effect. If the content of the arginine is less than 0.1% by weight, the bubble enhancing effect is low, and if it is more than 10% by weight, it is not preferable because formulation is difficult.

The composition for hypoallergenic oral cavity according to the present invention is not particularly limited in its formulation, and for specific examples, it may have formulations such as toothpaste, mouth freshener, and tooth whitening agent.

In addition, the composition for hypoallergenic oral use according to the present invention is an abrasive, a wetting agent, an auxiliary foaming agent, a binder, a sweetener, a pH adjuster, a preservative, an active ingredient, a fragrance, a brightener, a color, and a solvent, which are commonly used according to the formulation and purpose of use. and the like.

The abrasive includes calcium carbonate, precipitated silica, aluminum hydroxide, potassium monohydrogen phosphate and insoluble sodium metaphosphate, and these abrasives are mixed alone or in an amount of 1 to 60% by weight based on the total weight of the composition. can be used

The wetting agent includes glycerin, sorbitol solution, polyethylene glycol, and propylene glycol, and an amount of 1 to 80% by weight based on the total weight of the composition may be used alone or in combination of two or more.

Examples of the auxiliary foaming agent include anionic surfactants such as sulfate, sulfosuccinate, sarcosinate, phosphate, isethionate, and taurate, amphoteric surfactants such as sultaine and amphoacetate, and poly Nonionic surfactants such as oxyethylene sorbitan fatty acid ester, polyoxyethylene (hardened) castor oil, glycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, alkylolamide, and alkylglucoside, N-alkyldiaminoethylglycine An amount of 0.1 to 10% by weight based on the total weight of the composition may be used alone or by mixing two or more kinds of cationic surfactants such as.

As the binder, sodium carboxymethyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, xanthan gum, carrageenan, sodium alginate, etc. alone or in mixture of two types, based on the total weight of the composition, 0.1 to 10% by weight amount can be used.

As the sweetener, sodium saccharin, aspartame, stevioside, xylitol, licoric acid, etc. may be used alone or in an amount of 0.001 to 1% by weight based on the total weight of the composition by mixing two or more types.

As the pH adjusting agent, sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, citric acid, sodium citrate, tartaric acid, etc. may be used alone or in combination of two or more, and the preservative is methyl paraoxybenzoate, paraoxy Propyl benzoate, sodium benzoate, etc. may be used alone or in combination of two or more.

As the active ingredient, sodium fluoride, sodium monofluorophosphate, tin fluoride, chlorhexidine, allantoin chlorohydroxyaluminate, aminocaproic acid, triclosan, cetylpyridium chloride, zinc chloride, pyridoxine chloride, tocopherol acetate, etc. alone Or two or more types may be mixed and used.

As the perfume, peppermint oil, spearmint oil, menthol, anethol, etc. can be used alone or in an appropriate amount by mixing two or more types, titanium oxide is used as a brightener, food coloring is used as a colorant, and purified water or ethanol is used as a solvent. etc. can be used.

By adding the additives as described above with different compositions and contents according to the purpose and conditions, it can be prepared by a conventional toothpaste manufacturing method.

Hereinafter, the content of the present invention will be described in more detail through Examples and Test Examples. However, these Examples and Test Examples are only presented to understand the content of the present invention, and the scope of the present invention is not limited to these Examples and Test Examples, and modifications and substitutions commonly known in the art and insertion may be performed, and this is also included in the scope of the present invention.

<Production Example> Preparation of toothpaste

Examples 1 and 2 and Comparative Examples 1 to 4 were prepared according to the composition of Table 1 below, and the unit of Table 1 below is the weight % of the corresponding component with respect to the total weight of the composition.

ingredient content Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Purified water remaining amount remaining amount remaining amount remaining amount remaining amount remaining amount sodium fluoride 0.22 0.22 0.22 0.22 0.22 0.22 sodium saccharin 0.2 0.2 0.2 0.2 0.2 0.2 Soribtol solution 50 50 50 50 50 50 Spices One One One One One One dental type silica 13 13 13 13 13 13 Cellulose Gum One One One One One One Sodium Lauroyl Glutamate One One 1.5 Lauramidopropyl Betaine 0.5 0.5 1.5 arginine 0.3 Sodium Lauryl Sulfate 1.5 Sodium Cocoyl Glutamate One Cocoylamidopropyl dimethyl glycine solution 0.5

<Test Example 1> Foaming force evaluation test

In order to evaluate the foaming power of toothpaste using a glutamate-based surfactant and an amidopropyl betaine-based surfactant together, 5 g each of the toothpaste compositions of Examples 1 and 2 and Comparative Examples 1 to 4 of Table 1 were weighed in a beaker, and After adding 45 g of purified water to adjust the total content to 50 g, put in each 250 ml measuring cylinder, block the inlet, and measure the amount of bubbles generated while rotating 180 degrees each 8 times, which was repeated 3 times in total. Measurements were made by observing the scale of 250ml and recording the number of heights from 0 to which bubbles occurred, and the unit is ml. The measurement results are shown in Table 2 and FIG. 1 below.

Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 1 time 186.1 193.6 180.6 177.5 182.5 180.9 Episode 2 185.8 192.2 178.9 178.8 183.6 179.6 3rd time 187.2 194.8 179.8 179.6 182.4 182.7 average 186.4 193.5 179.8 178.6 182.8 181.1

In the results of Table 2, in the case of Example 1 containing both sodium lauroyl glutamate, which is a glutamate-based surfactant, and lauramidopropyl betaine, which is an amidopropyl betaine-based surfactant, and Example 2 that further contains arginine , sodium lauroyl glutamate, it was confirmed that the foaming power was much superior to those of Comparative Examples 1 and 2 containing each alone, respectively.

In addition, in the case of Examples 1 and 2, sodium cocoyl glutamate and cocoylamidopropyldimethylglycine solution, which are components generally contained in Comparative Example 3 using sodium lauryl sulfate and products not using sodium lauryl sulfate, It was confirmed that the foaming power was also excellent compared to Comparative Example 2 containing the.

Therefore, when sodium lauroyl glutamate and lauramidopropyl betaine are included together, or when arginine is further included therein, the foaming power is higher than those of Comparative Examples 1 to 4 using the above component alone or containing a conventionally used foaming agent. I was able to see that it was much better.

<Test Example 2> Irritation evaluation test for oral mucosa

In order to evaluate the irritation to the oral mucosa when a glutamate-based surfactant and an amidopropyl betaine-based surfactant are used together, 20 subjects sensitive to mucosal irritation were tested in Examples 1 and 2 and Comparative Examples 1 to 4 When about 1 g of each toothpaste composition was taken on a toothbrush and brushed for 3 minutes, irritation to the oral mucosa was evaluated. According to the degree of stimulation, “I do not feel the stimulation” is 1 point, “I hardly feel the stimulation” is 2 points, “I feel the stimulation” is 3 points, and “I feel the stimulation strongly” is 4 points, and the average value of 20 people. The irritation to the oral mucosa was evaluated from The evaluation results are shown in Table 3 below.

Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Average oral mucosal irritation score 1.4 1.3 2.1 2.7 3.2 2.2

In the results of Table 3, the toothpaste prepared by Comparative Example 3 containing sodium lauryl sulfate showed much greater irritation to the oral mucosa compared to Examples 1 and 2 and Comparative Examples 1, 2 and 4, In the case of Examples 1 and 2 according to the present invention, sodium lauroyl glutamate and lauramidopropyl betaine were used alone or compared to Comparative Examples 1 to 4 containing a conventionally used foaming agent, the irritation to the oral mucosa was It could be seen that there was a significant decrease.

<Test Example 3> Bitter taste and unpleasant taste evaluation test

In order to evaluate the feeling of use when using the glutamate-based surfactant and the amidopropyl betaine-based surfactant together, the toothpaste compositions of Examples 1 and 2 and Comparative Examples 1 to 4 were administered to 20 flavor panels, respectively. After taking 1 g of each of the toothbrushes and brushing the teeth for 3 minutes, bitter taste and unpleasant taste were evaluated. According to the degree of bitterness and unpleasant taste, each was evaluated on a 5-point scale (5 points: very strong, 4 points: strong, 3 points: moderate, 2 points: weak, 1 point: very weak), from the average value of 20 people. Bitter taste and unpleasant taste were evaluated. The evaluation results are shown in Table 4 below.

Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 bitter 1.2 1.2 2.0 2.2 2.2 2.9 unpleasant taste 1.5 1.4 2.4 2.5 2.4 3.0

In the results of Table 4, in the case of the toothpaste compositions of Examples 1 and 2 according to the present invention, Comparative Examples 1 to 4, in particular, compared to Comparative Example 4 containing sodium cocoyl glutamate and cocoylamidopropyldimethylglycine solution. It was confirmed that the degree of bitter taste and unpleasant taste was much lower.

As described above, the composition for hypoallergenic oral use according to the present invention contains both a glutamate-based surfactant and an amidopropyl betaine-based surfactant, and has excellent bubble generation and extremely low irritation to the oral mucosa, bitter taste and unpleasant taste reduced, and the feeling of use is excellent.

Claims (7)

A hypoallergenic composition for oral use comprising a glutamate-based surfactant and an amidopropyl betaine-based surfactant, but not a sulfate-based surfactant. The method of claim 1,
The glutamate-based surfactant is sodium lauroyl glutamate (Sodium Lauroyl Glutamate), characterized in that, hypoallergenic oral composition. The method of claim 1,
The amidopropyl betaine-based surfactant is lauramidopropyl betaine (Lauramidopropyl Betaine), a hypoallergenic oral composition. The method of claim 1,
The mixing ratio of the glutamate-based surfactant and the amidopropyl betaine-based surfactant is 1 to 3 : 1 by weight, a hypoallergenic composition for oral cavity. The method of claim 1,
The hypoallergenic composition for oral use, characterized in that the glutamate-based surfactant and the amidopropyl betaine-based surfactant are included in an amount of 0.5 to 2.5% by weight based on the total weight of the composition. The method of claim 1,
A hypoallergenic composition for oral cavity, characterized in that it further comprises arginine. 7. The method of claim 6,
The arginine is characterized in that it is included in an amount of 0.1 to 10% by weight based on the total weight of the composition, hypoallergenic composition for oral use.