KR20110090216A - Oral composition for improving remineralization - Google Patents

Abstract

PURPOSE: An oral composition for promoting remineralization is provided to enhance tooth strength without irritation to human oral cavity mucous. CONSTITUTION: An oral composition for promoting remineralization contains 0.005-1.0 weight parts of pearl powder. The diameter of the pearl powder particle is 0.05-0.30 mm. The composition is manufactured in the form of toothbrush, oral cleaning agent, mouth rinse, or chewing gum. The oral composition enhances the strength of teeth.

Description

Oral composition for remineralization {Oral composition for improving remineralization}

The present invention relates to an oral composition for promoting remineralization, and more particularly, to an oral composition for promoting remineralization that promotes remineralization of teeth to increase the strength of teeth.

There are many causes of tooth damage, but the damage is caused by acid, a metabolite of bacteria present in the oral cavity. Acid-induced damage is called dental caries, which is the result of a loss of equilibrium in demineralization and remineralization in the teeth. Formation of glucans by S. mutans in the oral cavity causes bacteria to aggregate and form plaques, and dental caries is caused by acid emitted from numerous metabolism of plaques. Although the demineralization by acid occurs on the surface of the teeth, the remineralization reaction proceeds by refilling the part demineralized by the minerals present in saliva, but the excess acid erosion develops into tooth caries.

As a method for suppressing such dental caries, prevention of dental caries by improving tooth acid resistance due to fluorine compounds, promotion of remineralization by hydroxyapatite, inhibition of bacteria by fungicides, and the like. U. S. Patent No. 4,080, 440 proposes a solution of calcium and phosphate ions at low pH with high solubility of hydroxyapatite, but there is a problem that can cause irritation of the oral mucosa at low pH. Korean Patent Publication No. 2000-36080 relates to a remineralizing composition of two phases, and suggests to include a calcium ion source and a phosphate ion source together with a water-soluble polyphosphate, but the calcium phase and the phosphate phase are separated and mixed when used. There is a risk of irritation because the pH is lowered when mixing in the form, and the cost of the packaging material for the separate filling also increases.

An object of the present invention to solve the above problems is to provide an oral composition for promoting remineralization to promote remineralization of the teeth to increase the strength of the teeth.

The present invention to achieve the above object

An oral composition for promoting remineralization containing pearl powder is provided.

The pearl powder may be included in an amount of 0.005 to 1 part by weight based on the composition.

The diameter of the particles of the pearl powder may be 0.05 to 0.30 mm.

The composition of the present invention promotes remineralization of the teeth to increase the strength of the teeth.

The composition of the present invention does not irritate the human oral mucosa and is safe for the human oral mucosa even when used for a long time.

Hereinafter, the present invention will be described in detail so that those skilled in the art can easily practice.

The oral composition of the present invention contains pearl powder.

The oral composition of the present invention may promote pearl remineralization by containing pearl powder.

Pearl contains more than 85% calcium carbonate and various minerals such as Na, K, Li, Sr, Mg, Mn, Fe and Zn. Calcium ions are released into saliva by the calcium carbonate of pearls, thereby increasing the concentration of calcium ions in saliva, thereby facilitating remineralization by calcium. The pearl is not limited in kind, and those known in the art can be used without limitation. In addition, the pearl may be added to the oral composition of the present invention in various forms within the scope of not impairing the object of the present invention, but is preferably added in powder form in consideration of the usability and the like.

The pearl powder may be included in an amount of 0.005 to 1.0 parts by weight, and preferably 0.01 to 0.5 parts by weight, based on the composition. If less than 0.005 parts by weight of the re-mineralization promoting effect may be insignificant, and when included in excess of 1.0 parts by weight may not be good, and the increase of the effect is so small that the increase in cost compared to the increase in efficacy is not preferable. not.

The diameter of the particles of the pearl powder may be 0.05 to 0.30 mm. If the diameter of the particles of the pearl powder is less than 0.05 mm can be easily dispersed in the solvent may reduce the tooth adhesion of the particles, if the diameter exceeds 0.30 mm may not be good, irritating gums.

The oral composition of the present invention is a component commonly used in the art within the scope of not impairing the object of the present invention in addition to the above components, for example, wetting agents, sweeteners, thickeners, caries preventive agents, tartar preventive agents, foaming agents, preservatives, etc. It may include. Specifically, the humectant may be glycerin, sorbitol, polyethylene glycol, or the like, and the sweetener may be specifically, sodium saccharin, xylitol, stevia, erythritol, or the like, and the thickener may be xanthan gum, carboxymethylcellulose sodium. , Poloxamer 407, polyvinylpyrrolidone and the like can be used. The caries prevention agent may be specifically, sodium fluoride, sodium monofluorophosphate, and the like, the tartar preventive agent may be used sodium pyrophosphate, potassium pyrophosphate, etc., the foaming agent is specifically sodium lauryl sulfate, sodium salcosinate , Cocoamidopropylbetaine and the like can be used. The preservative may be used methyl paraoxybenzoate, propyl paraoxybenzoate, sodium benzoate and the like. The above components may be used alone or in combination of two or more thereof. In addition to the components contained in a small amount may be added a colorant, a binder, a perfume. As the medicinal component, one or more of aminocaproic acid, allantoinhydroxyaluminate, chlorohexidine, tocopherol acetate and pyridoxine hydrochloride can be used in combination.

The oral composition of the present invention can be applied to any shape such as paste, solid, liquid or chewing gum (Gum), and can be formulated into various oral preparations such as toothpaste, tooth powder, jelly, caramel, candy, and mouthwash. If necessary, it can be blended with components generally used in preparations for oral cavity, such as aqueous components, oily components, surfactants, humectants, thickeners, preservatives, flavoring agents, pigments, etc., within the range that does not impair the effects of the present invention. Can be.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. This is for the purpose of illustrating the invention only, and thus the scope of the invention is not limited.

< Example  1 to 6> Preparation of Toothpaste

Toothpaste was prepared using a conventional method known in the art with the composition of Table 1 below.

ingredient Example
One Example
2 Example
3 Example
4 Example
5 Example
6 Sorbitol 60 60 60 60 60 60 Silica 20 20 20 20 20 20 Polyethylene glycol 5 5 5 5 5 5 Sodium Lauryl Sulfate 2.0 2.0 2.0 2.0 2.0 2.0 Saccharin Sodium 0.1 0.1 0.1 0.1 0.1 0.1 Carboxymethyl Cellulose Sodium 0.4 0.4 0.4 0.4 0.4 0.4 Sodium monofluorophosphate 0.75 0.75 0.75 0.75 0.75 0.75 Pearl powder (0.10 mm) 0.005 0.01 0.5 1.0 - - Pearl powder (0.05 mm) - - - - 0.5 - Pearl powder (0.30 mm) - - - - 0.5 Purified water to 100 to 100 to 100 to 100 to 100 to 100

< Comparative example  1-5> Preparation of Toothpaste

Toothpaste was prepared in the same manner as in the example in the composition of Table 2 below.

ingredient Comparative example
One Comparative example
2 Comparative example
3 Comparative example
4 Comparative example
5 Sorbitol 60 60 60 60 60 Silica 20 20 20 20 20 Polyethylene glycol 5 5 5 5 5 Sodium Lauryl Sulfate 2.0 2.0 2.0 2.0 2.0 Saccharin Sodium 0.1 0.1 0.1 0.1 0.1 Carboxymethyl Cellulose Sodium 0.4 0.4 0.4 0.4 0.4 Sodium monofluorophosphate 0.75 0.75 0.75 0.75 0.75 Pearl powder (0.10 mm) - - - 0.001 1.5 Pearl powder (0.01 mm) 0.5 - - - - Pearl powder (0.50 mm) - 0.5 - - - Purified water to 100 to 100 to 100 to 100 to 100

< Experimental Example  1> Measurement of change in hardness of teeth

Specimens were prepared by dividing the human teeth into four halves for testing under the same conditions. Each specimen was impregnated in a deliming solution and stored at 37 ° C. for 5 days. The composition of the deliming solution was 3 mM CaCl ₂ · 2H ₂ O, 2 mM KH ₂ PO ₄ , 50 mM CH ₃ COOH, and adjusted to pH 4.5 using KOH. Demineralized tooth in the weight ratio of the toothpaste and water of the above Examples and Comparative Examples 1: 2 After impregnating the mixed slurry was stored for 5 days at 37 ℃, washed with distilled water and dried, the strength was measured using a hardness tester. The results are shown in Table 3 below. The units in Table 3 below are Vickers hardness units.

Example Comparative Example One 2 3 4 5 6 One 2 3 4 5 Hardness
(kg / ㎡) 21.5 34.2 47.7 61.4 46.9 41.4 31.1 22.5 15.4 15.7 60.7

According to Table 3, it can be seen that the toothpaste of the example containing the pearl powder had an increased strength of the tooth after use compared to the toothpaste of the comparative example. That is, it is predicted that remineralization is accelerated by the pearl powder and the strength of the teeth is increased. In the toothpaste of Comparative Example 5, the content of pearl powder was high, and thus the strength was increased similarly to the example.

As described above, it can be seen that the oral composition of the present invention promotes remineralization to improve the strength of the tooth.

Claims (4)

An oral composition for promoting remineralization, comprising pearl powder. The method of claim 1,
Oral composition for promoting remineralization, characterized in that the pearl powder is contained in an amount of 0.005 to 1.0 parts by weight based on the composition. The method of claim 1,
Oral composition for promoting remineralization, characterized in that the diameter of the particles of the pearl powder is 0.05 to 0.30 mm. The method of claim 1,
Oral composition for promoting remineralization, characterized in that the formulation of the composition is a toothpaste, mouthwash, oral rinse or chewing gum (gum).