WO2018230325A1

WO2018230325A1 - Composition for use in oral cavity

Info

Publication number: WO2018230325A1
Application number: PCT/JP2018/020506
Authority: WO
Inventors: 典浩高下; 卓小倉
Original assignee: ライオン株式会社
Priority date: 2017-06-15
Filing date: 2018-05-29
Publication date: 2018-12-20
Also published as: KR20200015449A; JP2019001747A; CN110198699A

Abstract

A composition for use in the oral cavity characterized by containing (A) hexagonal plate-like zinc oxide. The present invention makes it possible to provide a composition for use in the oral cavity having an excellent tooth whitening effect.

Description

Oral composition

The present invention relates to a composition for oral cavity that has an excellent whitening effect on teeth.

Conventionally, the following proposal has been made as a chemical whitening technique for teeth to make the teeth appear whiter than the original color.
(1) Whitening teeth using bleach.
(2) Whitening of teeth by holding and fixing a whitening composition using a chelating agent, specifically polyphosphate, etc. to the teeth using an application tool (Patent Document 1; JP 2000-281548 A) Publication).
(3) Whitening of a tooth by attaching a non-aqueous composition using a specific solvent and copolymer to the tooth so as to be detachable using an application tool (Patent Document 2; JP-A-2006-8530).
(4) Fix the white powder by applying a composition containing white powder such as titanium dioxide, silicon dioxide, zinc oxide, etc. to the teeth with an application tool, or preparing a film preparation and applying it to the teeth. A method of making it appear white (Patent Document 3; Japanese Patent No. 483155, Patent Document 4; Japanese Patent Application Laid-Open No. 2008-1649).

JP 2000-281548 A JP 2006-8530 A Japanese Patent No. 483155 JP 2008-1649 A

However, (1) has a problem in safety, and in (2) to (4), there is room for improvement in terms of simplicity because a fixing means may be used for whitening the teeth. Development of a simple and effective whitening technique for teeth was desired.

This invention is made | formed in view of the said situation, and it aims at providing the composition for oral cavity which is excellent in the whitening effect of a tooth | gear.

As a result of intensive studies to achieve the above object, the present inventors have found that (A) hexagonal plate-like zinc oxide has an excellent whitening effect on teeth, and when this is blended into an oral composition, It has been found that it has an excellent whitening effect that makes it whiter than the color. That is, according to the present invention, by blending (A) hexagonal plate-like zinc oxide into the oral composition, an excellent tooth whitening effect is provided, thereby allowing normal tooth brushing and washing without using fixing means. It has been found that even with the mouth alone, the whiteness of the teeth stands out, the brightness of the teeth increases, and the teeth can appear much whiter than the original color, and the present invention has been made.

Hexagonal plate-like zinc oxide is known as a component of skin cosmetics such as foundations as an ultraviolet light inhibitor, but in preparations applied to the oral cavity, amorphous particles are generally used as zinc oxide. It was done. Therefore, single crystal particles are not applied as zinc oxide, and the composition of hexagonal plate-like zinc oxide into the oral composition has not been known so far. On the other hand, in the present invention, (A) hexagonal plate-like zinc oxide, particularly preferably hexagonal plate-like zinc oxide having a specific average particle diameter and average thickness, is an excellent tooth in an oral composition. The whitening effect of the present invention is achieved, and there is a special effect that cannot be obtained by using other white pigments. Furthermore, in the present invention, not only the above-described whitening effect but also an astringent feeling derived from zinc oxide can be appropriately imparted by the component (A) to give a good feeling of use.
In addition, although the whitening technique of the tooth | gear using the zinc oxide which is a white pigment is well-known (patent document 3), as above-mentioned, the zinc oxide used for a composition for oral cavity is usually an amorphous particle. Even with zinc oxide, the effect of the present invention cannot be obtained with irregularly shaped particles. As shown in a comparative example described later, the whitening effect is inferior when an amorphous zinc oxide powder is used instead of the component (A), and even when it is a hexagonal plate, mica titanium may be used. The whitening effect is inferior, and the effect of the present invention is inferior in these.
In the present invention, although the details of the mechanism of action are not clear, the effect of making the teeth whiter is excellent and the astringent feeling is satisfied by the contribution of the film-forming ability of the component (A) and the retention in the oral mucosa. It is speculated that it can also be granted.

Accordingly, the present invention provides the following oral composition.
[1]
(A) A composition for oral cavity containing hexagonal plate-like zinc oxide.
[2]
The oral composition according to [1], wherein the hexagonal plate-like zinc oxide has an average particle size of 0.1 to 10 μm.
[3]
The oral composition according to [1] or [2], wherein the hexagonal plate-like zinc oxide has an average thickness of 0.01 to 1 μm.
[4]
The composition for oral cavity according to any one of [1] to [3], wherein the average particle diameter / average thickness is 0.5 to 50 and represents the ratio between the average particle diameter and the average thickness of hexagonal plate-like zinc oxide .
[5]
The composition for oral cavity according to any one of [1] to [4], which is a non-sheet-form preparation containing 0.1 to 30% by mass of component (A).
[6]
The composition for oral cavity according to [5], which is a dentifrice or mouthwash.
[7]
The oral composition according to any one of [1] to [4], which is a sheet-form preparation containing 0.1 to 95% by mass of component (A).
[8]
The oral composition according to any one of [1] to [7], further comprising (B) a surfactant in an amount of 0.1 to 10% by mass.
[9]
The oral composition according to any one of [1] to [8], which is used for whitening teeth.

According to the present invention, an oral composition having an excellent whitening effect on teeth can be provided. The composition for oral cavity of the present invention can be effectively used for whitening teeth because it can easily and effectively whiten teeth and make the teeth whiter than the original color.

It is a two-dimensional image which shows the shape of (A) zinc oxide (hexagonal plate shape) used in the Example of this invention.

In the present invention, (A) hexagonal plate-like zinc oxide is blended in an oral composition as an active ingredient for whitening teeth.

(A) Hexagonal plate-like zinc oxide has a whitening effect on teeth and gives a sense of convergence. The hexagonal plate-like zinc oxide is not particularly limited as long as it is hexagonal and plate-like particles, and known single crystal hexagonal plate-like zinc oxide can be used. The hexagonal plate-like zinc oxide can be used by being dispersed in water.

The average particle size of the hexagonal plate-like zinc oxide is preferably 0.1 μm or more, more preferably 0.5 μm or more, still more preferably 1 μm or more, particularly 1.5 μm or more, and preferably 10 μm or less, more preferably It is 8 μm or less, more preferably 5 μm or less. When it is 0.1 μm or more, the whitening effect is sufficiently exhibited. When the thickness is 10 μm or less, the convergence feeling is sufficiently exhibited. The “particle size” of the hexagonal plate-like zinc oxide in the present invention is an average value of the lengths of the three diagonal lines of the hexagonal surface of the hexagonal plate-like particle.
The average particle size was calculated by image analysis, specifically, by randomly selecting 20 hexagonal plate-like zinc oxides, and measuring and averaging the lengths of the diagonal lines of each particle. For the particle size measurement, a scanning electron microscope (SEM) JSM7600F manufactured by JEOL Ltd. was used. The particle size of each particle was measured by averaging the lengths of three hexagonal diagonal lines from the image from the Z-axis direction (the same applies hereinafter).

The average thickness of the hexagonal plate-like zinc oxide is preferably 0.01 μm or more, more preferably 0.1 μm or more, still more preferably 0.2 μm or more, and preferably 1 μm or less, more preferably 0.8 μm or less. More preferably, it is 0.7 μm or less. When the average thickness is 0.01 μm or more, the whitening effect is sufficiently exhibited. When the thickness is 1 μm or less, a feeling of convergence is sufficiently exhibited. The “thickness” of hexagonal plate-like zinc oxide in the present invention is a distance between two hexagonal surfaces of hexagonal plate-like particles.
In addition, said average thickness uses the scanning electron microscope (SEM) JSM7600F by JEOL Co., Ltd., 20 hexagonal plate-like zinc oxides were selected at random, and each particle | grain was measured from the image from the Y-axis direction. The thickness was calculated by measuring and averaging. The thickness of each particle was measured by measuring the distance (length) between the plate-like upper surface and lower surface (the same applies hereinafter).

The hexagonal plate-like zinc oxide shows the ratio between the average particle diameter and the average thickness, and the average particle diameter / average thickness is preferably 0.5 or more, more preferably 1 or more, and further preferably 2 or more. Moreover, 50 or less is preferable, More preferably, it is 30 or less, and may be 5 or less. When the average particle size / average thickness is 0.5 or more, the whitening effect is sufficiently exhibited. When it is 50 or less, a feeling of convergence is sufficiently exhibited.

Further, the oil absorption amount of hexagonal plate-like zinc oxide is preferably 45 g / 100 g or less, more preferably 36 g / 100 g or less. The oil absorption was measured according to JIS K-5101-13-1.

As such hexagonal plate-like zinc oxide, commercially available products can be used. Examples include hexagonal plate-like zinc oxide XZ series XZ-100F, XZ-300F, XZ-1000F, XZ-2000F, and XZ-3000F (all manufactured by Sakai Chemical Industry Co., Ltd.).

(A) Although the compounding quantity of hexagonal plate-shaped zinc oxide is not restrict | limited in particular, Preferably it is 0.1% (mass%, the following is similar) or more of the whole composition, 0.5% or more especially, 1% or more especially. . Moreover, 95% or less of the whole composition is preferable, More preferably, it is 30% or less, Especially 20% or less, Especially 10% or less. When it is 0.1% or more, the whitening effect is sufficiently exhibited, and the convergence feeling is sufficiently exhibited. If not added too much, it is possible to prevent a strong metallic taste and maintain a good feeling of use. In this respect, 95% or less is good.

Further, it can be prepared in a general form as a composition for oral cavity, for example, a non-sheet form such as a dentifrice and a mouthwash. In such a non-sheet-form preparation, the blending amount of the component (A) is preferably 0.1 to 30%, particularly preferably 0.1 to 20%, more preferably 0.1 to 5% of the whole composition, More preferably, it is 0.5 to 3%, and particularly preferably 1.0 to 2%.
Moreover, although the composition for oral cavity of this invention can be prepared also in sheet-like forms, such as a pack agent and a film agent, as mentioned later, in such a sheet-form preparation, (A) component is compared compositionally. Can be blended as much as possible. In this case, the blending amount of the component (A) can be 0.1 to 95% of the whole composition from the viewpoint of the whitening effect and the feeling of use, but is preferably 0.1 to 20%, more preferably 0.1 to 5%.

In the present invention, it is preferable to further blend (B) a surfactant. When (B) a surfactant is added, the dispersibility of the component (A) is improved and the whitening effect is further increased.

Examples of the surfactant include known anionic surfactants, nonionic surfactants, and amphoteric surfactants for oral use, and any of them may be used. Specific examples of anionic surfactants include alkyl sulfates such as sodium lauryl sulfate, N-acyl sarcosine salts such as N-lauroyl sarcosine sodium, acyl amino acid salts such as N-acyl glutamate, and α-olefin sulfonic acids. Sodium etc. are mentioned.
Nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters such as decaglyceryl monolaurate, and average added moles of ethylene oxide ( And polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil having an EO) of 10 to 60, fatty acid alkanolamides such as polyoxyethylene higher alcohol ethers and lauric acid diethanolamide.
Examples of amphoteric surfactants include betaine types such as alkylbetaines, alkyldimethylaminoacetic acid betaines, fatty acid amidopropyl betaines, fatty acid amidopropyldimethylaminoacetic acid betaines, betaine types such as alkylimidazolinium betaines, and N-fatty acid acyl-N. Examples include imidazoline type such as -carboxymethyl-N-hydroxyethylethylenediamine salt.
Among these, anionic surfactants are particularly preferable, anionic surfactants having a sulfonic acid group are more preferable, and alkyl sulfates and α-olefin sulfonates are more preferable. In particular, sodium lauryl sulfate and sodium tetradecenesulfonate are preferable from the viewpoint of dispersibility of the component (A).
The blending amount of the (B) surfactant is preferably from 0.1 to 10%, particularly preferably from 1 to 5%, based on the entire composition.

The composition for oral cavity of the present invention can be made into paste, gel, liquid such as liquid, solid, etc., and prepared as a toothpaste such as toothpaste, liquid dentifrice, liquid dentifrice, mouthwash, etc. obtain. Furthermore, it is also possible to prepare a form that can be applied to teeth without using a fixing means, specifically, a sheet-form oral preparation such as a pack or film. In particular, dentifrices or mouthwashes are preferred in terms of the manifestation and usability of this effect.
Here, the pack agent is a preparation in which the plaster surface of a sheet is attached to a tooth, the support is peeled off, the plaster is transferred onto the tooth surface, and the plaster is used as a dentifrice or the like. A film agent is a preparation in which the entire film is used as a dentifrice etc. by sticking the film to the tooth surface and brushing as it is. For example, a tooth having a length of 2.5 cm, a width of 2 cm, and a thickness of about 0.3 mm The size and shape can be adjusted.

In this case, depending on the purpose of the composition, dosage form, and the like, in addition to the above-described components, components that are commonly blended for oral compositions can be blended as necessary, depending on the form and the like. It can be prepared by conventional methods. For example, abrasives, thickeners, binders, sweeteners, preservatives, colorants, fragrances, active ingredients other than the component (A), and the like can be blended. Moreover, in a sheet agent, various gelling agents can also be used in order to gelatinize and paste and to improve the applicability to a tooth and adhesiveness with a tooth.

Examples of the abrasive include silica-based abrasives such as precipitated silica, aluminosilicate, zirconosilicate, calcium phosphate-based abrasives, calcium carbonate and the like (the amount is usually 2 to 50%, particularly 10 to 40%). ).

Examples of the wetting agent (thickening agent) include sugar alcohols such as sorbit and xylite, glycerin, propylene glycol, and polyhydric alcohols such as polyethylene glycol having an average molecular weight of 160 to 4000 (average molecular weight described in Quasi-drug Raw Material Standard 2006). (The amount is usually 5 to 50%).

Examples of binders include cellulose derivatives such as sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, alginic acid or its derivatives such as sodium alginate, gums such as xanthan gum, organic binders such as carrageenan, polyvinyl alcohol, and sodium polyacrylate. And inorganic binders such as an agent, gelling silica, gelling aluminum silica, bee gum, and laponite (the blending amount is usually 0.1 to 10%).

Examples of the sweetening agent include sodium saccharin, and examples of the preservative include paraoxybenzoic acid esters such as methyl paraoxybenzoate, benzoic acid such as sodium benzoate, and salts thereof.
Examples of the colorant include blue No. 1, yellow No. 4, titanium dioxide and the like.

Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, bran oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfumes, etc.) and menthol, Rubon, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-l-Mentoxypropane-1,2-diol, Thymol, Linalool, Linarel acetate, Limonene, Menthone, Menthyl acetate, N-Substituted paramenthane 3-carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethyl Oral compositions such as single flavors such as oacetate, and other flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. It can be used in combination with known perfume materials used in the above. The blending amount is not particularly limited, but usually 0.000001 to 1% is preferable for the above fragrance materials, and 0.1 to 2% is preferable for the fragrance materials using the above fragrance materials.

Active ingredients include fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate, cationic fungicides such as isopropylmethylphenol and cetylpyridinium chloride, enzymes such as anti-inflammatory agents and dextranase, and water-soluble phosphoric acid. Examples thereof include compounds, copper compounds, vitamins, plant extracts, calculus inhibitors, and plaque inhibitors. The active ingredient can be blended in an effective amount as long as the effects of the present invention are not hindered.

When preparing into a sheet-form oral preparation, the same material as the above-mentioned binder can be used as a gelling agent, but from the viewpoint of use feeling in the mouth, sodium carboxymethylcellulose, hydroxyethylcellulose, Cellulose derivatives such as hydroxypropyl cellulose, polyvinyl alcohol, and sodium alginate are preferred (the amount is preferably 1 to 5%).

In the present invention, the sheet-form oral preparation is not particularly limited as long as it can be applied to teeth, and there is no particular limitation on the shape, thickness, etc., usage form, and the like, even in a form that can be applied to one or more tooth surfaces. Well, it can also be used as a dentifrice by sticking on the tooth surface and brushing as it is after use.
In addition, it is preferable that the plaster composition is spread and integrated on the support so that the plaster composition is peelable. As the support, a water-insoluble material is preferably used, and examples thereof include films, nonwoven fabrics, woven fabrics, and mesh fabrics of materials such as polypropylene, polyethylene, and polyurethane. The film may be a single layer or a laminated film, or a laminated sheet of a film and unemployed cloth, woven cloth or net cloth. Further, the plaster composition may be protected by coating a release liner. These can use a commercial item.

Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
Prepare aqueous dispersions (simple systems) having the compositions shown in Tables 1 and 2 and dentifrices, mouth washes, packs or film preparations (formulation systems) having the compositions shown in Tables 3 to 7, respectively. Evaluation was performed by the method shown. The results are shown in the table.

Details of the raw materials used are shown below.
(A) Zinc oxide (hexagonal plate shape);
Hexagonal zinc oxide XZ series (XZ-100F, 300F, 1000F, 2000F, 3000F), manufactured by Sakai Chemical Industry Co., Ltd., single crystal XZ-100F: average particle size 0.1 μm, average thickness 0.03 μm, Oil absorption 42g / 100g
XZ-300F: Average particle size 0.3 μm, average thickness 0.08 μm, oil absorption 37 g / 100 g
XZ-1000F: Average particle diameter 1 μm, average thickness 0.3 μm, oil absorption 36 g / 100 g
XZ-2000F: Average particle diameter 2 μm, average thickness 0.5 μm, oil absorption 34 g / 100 g
XZ-3000F: Average particle size 3 μm, average thickness 0.8 μm, oil absorption 32 g / 100 g
These raw materials were classified appropriately and used for experiments. The average particle diameter and average thickness of the samples used are shown in the table.
Zinc oxide (powder, comparative product);
Amorphous powder, Japanese Pharmacopoeia zinc oxide, manufactured by Sakai Chemical Industry Co., Ltd., amorphous
Average particle size 2μm, average thickness 2μm, oil absorption 59g / 100g
Mica titanium (hexagonal plate, comparative product);
TIMIRON MP-149, manufactured by Merck Ltd., single crystal,
Average particle size 2μm, average thickness 0.5μm

The measuring method of said average particle diameter and average thickness is shown below.
Measuring the average particle size;
It was calculated by image analysis, and measured and analyzed in the same manner as described above using a scanning electron microscope (SEM) JSM7600F manufactured by JEOL. From the image from the Z-axis direction, the lengths of the three diagonal lines of the hexagon were measured to obtain the particle size, and the average particle size was calculated.
Average thickness measurement method;
Using a scanning electron microscope (SEM) JSM7600F manufactured by JEOL Ltd., measurement was performed in the same manner as described above, and an average value was obtained. The length of the plate-like upper and lower surfaces of the particles was measured to obtain the thickness, and the average thickness was calculated.
In addition, the measuring method of the average particle diameter of zinc oxide (hexagonal plate shape) and mica titanium (hexagonal plate shape) and average thickness is as described above, respectively, and the average particle size of zinc oxide (powdered shape) is The average thickness is measured by a laser diffraction scattering type particle size distribution measuring apparatus LA-920 manufactured by HORIBA, Ltd. Since the shape of zinc oxide (powder) is nearly spherical, the average particle size is defined as the average thickness for convenience. did.
The oil absorption was measured according to JIS K-5101-13-1.
FIG. 1 shows a two-dimensional image of (A) zinc oxide (hexagonal plate) (taken using a scanning electron microscope (SEM) JSM7600F manufactured by JEOL Ltd.).

Evaluation method-1: Lightness measurement method of hydroxyapatite (HAP) plate and evaluation method of degree of whiteness (simple system)
Zinc oxide was weighed and dispersed in 100 ml of water. A hydroxyapatite (HAP) plate having a diameter of 7 mm was put in this dispersion, and after 3 minutes, the HAP plate was taken out and lightly rinsed with 100 ml of water. This HAP plate was measured with a color difference meter (spectral color difference meter SE-2000, manufactured by Nippon Denshoku Industries Co., Ltd.) to obtain a value of ΔL which is an index of brightness. As a control, an untreated product (untreated HAP plate) was measured in the same manner. The comparative example was similarly measured according to the above method.
In addition, a questionnaire was conducted on the degree of whiteness of the HAP plate for 10 subjects. A score (1 to 4 points) was assigned based on the following criteria, and an average value was calculated from the obtained results. From the calculated average score, the degree of whiteness of the HAP plate was evaluated based on the following evaluation criteria. An untreated HAP plate was used as a control.
[Score standard]
4 points: very white 3 points: white 2 points: slightly white 1 point: not white [Evaluation Criteria]
☆: Average value 3.5 points or more ◎: Average value 3.0 points or more and less than 3.5 points ○: Average value 2.5 points or more and less than 3.0 points △: Average value 2.0 points or more and 2.5 points Less than ×: Average value less than 2.0 points

Evaluation method-2: Lightness measurement method of hydroxyapatite (HAP) plate and evaluation method of degree of whiteness (formulation system)
Dentifrices, packs (plasters), and film preparations were diluted three times with water to prepare a dispersion of about 100 ml, which was used as an evaluation solution. The mouthwash was directly used as an evaluation solution. A hydroxyapatite (HAP) plate having a diameter of 7 mm was put in this dispersion, and after 3 minutes, the HAP plate was taken out and lightly rinsed with 100 ml of water. This HAP plate was measured with a color difference meter (spectral color difference meter SE-2000, manufactured by Nippon Denshoku Industries Co., Ltd.) to obtain a value of ΔL which is an index of brightness. As a control, an untreated product (untreated HAP plate) was measured in the same manner. The comparative example was similarly measured according to the above method.
Further, the degree of whiteness of the HAP plate was evaluated in the same manner as in the evaluation method-1.

Evaluation method-3: Evaluation method of astringency (formulation system)
A questionnaire was conducted on 10 subjects about the degree of convergence after using each preparation. A score (1 to 4 points) was assigned based on the following criteria, and an average value was calculated from the obtained results. Based on the average value of the calculated scores, the degree of convergence after brushing was evaluated based on the following evaluation criteria.
In each dentifrice, tooth brushing was performed for each subject by taking about 1 g of the dentifrice composition on a toothbrush, brushing for 3 minutes, and rinsing the oral cavity with water. The other preparations were used in the usual manner.
[Score standard]
4 points: A feeling of convergence was high 3 points: A feeling of convergence was felt 2 points: A little feeling of convergence was felt 1 point: A feeling of convergence was not felt [Evaluation criteria]
☆: Average value 3.5 points or more ◎: Average value 3.0 points or more and less than 3.5 points ○: Average value 2.5 points or more and less than 3.0 points △: Average value 2.0 points or more and 2.5 points Less than ×: Average value less than 2.0 points

*: Average particle diameter of titanium mica, thickness, and ratio of both

*: Average particle diameter of titanium mica, thickness, and ratio of both

**: The pack agent was prepared in the same shape by the same method as the adhesive sheet in the examples of JP-A-2016-117682, except that the plaster composition and the support having the above composition were used. The plaster composition was applied to a support, and spread while being sandwiched between the support and a silicone coating surface of a release liner (BD binder of film binder 75E-001 manufactured by Fujimori Kogyo Co., Ltd.). The obtained sheet was punched out for the upper jaw (width (parallel to the dentition) 62 mm, length 24 mm) and lower jaw (width 52 mm, height 24 mm), and cut and folded lines were also prepared. . After the pack agent was affixed to the tooth surface and the support was peeled off, it was used after brushing.

***; The film agent was prepared in a size of 2.5 cm in length, 2 cm in width, and 0.3 mm in thickness by a usual method. After the film agent was applied to the tooth surface, it was used after brushing.

Claims

(A) A composition for oral cavity containing hexagonal plate-like zinc oxide.
The oral composition according to claim 1, wherein the hexagonal plate-like zinc oxide has an average particle size of 0.1 to 10 µm.
The oral composition according to claim 1 or 2, wherein the hexagonal plate-like zinc oxide has an average thickness of 0.01 to 1 µm.
The composition for oral cavity according to any one of claims 1 to 3, wherein the average particle diameter / average thickness is 0.5 to 50 and represents a ratio between an average particle diameter and an average thickness of hexagonal plate-like zinc oxide. .
The oral composition according to any one of claims 1 to 4, which is a non-sheet preparation containing 0.1 to 30% by mass of component (A).
The composition for oral cavity according to claim 5, which is a dentifrice or a mouthwash.
The composition for oral cavity according to any one of claims 1 to 4, which is a sheet-form preparation containing 0.1 to 95% by mass of component (A).
The oral composition according to any one of claims 1 to 7, further comprising 0.1 to 10% by mass of (B) a surfactant.
The composition for oral cavity according to any one of claims 1 to 8, which is used for whitening teeth.