KR20200015449A - Oral Composition - Google Patents

Abstract

(A) A composition for oral cavity containing hexagonal plate-shaped zinc oxide. According to the present invention, it is possible to provide a composition for oral cavity excellent in whitening effect of teeth.

Description

Oral Composition

This invention relates to the composition for oral cavity which was excellent in the whitening (whitening) effect of a tooth.

Background Art Conventionally, the following proposal has been proposed as a chemical whitening technique of teeth for making teeth appear whiter than the original color.

(1) Teeth whitening using bleach.

(2) Whitening of teeth by holding and fixing a whitening composition using a chelating agent, specifically, a polyphosphate, etc., on the teeth using an application tool (Patent Document 1; Japanese Patent Laid-Open No. 2000-281548) .

(3) Whitening of teeth by attaching a non-aqueous composition using a specific solvent and a copolymer to a tooth detachably using an application tool (Patent Document 2; Japanese Patent Laid-Open No. 2006-8530).

(4) A method of fixing white powder to make it look white by mounting a composition containing white powder such as titanium dioxide, silicon dioxide, zinc oxide, etc. on the tooth with an application tool, or by preparing a film formulation and applying it to the tooth (patent Document 3; Japanese Patent No. 483155, Patent Document 4; Japanese Patent Publication No. 2008-1649).

Japanese Patent Laid-Open No. 2000-281548 Japanese Patent Publication No. 2006-8530 Japanese Patent No. 483155 Japanese Patent Publication No. 2008-1649

However, (1) has a problem in terms of safety, and in (2) to (4), since fixing means may be used for whitening teeth, there is room for improvement in terms of simplicity, In addition, the development of effective tooth whitening techniques has been desired.

This invention is made | formed in view of the said situation, and an object of this invention is to provide the composition for oral cavity which is excellent in the whitening effect of a tooth.

MEANS TO SOLVE THE PROBLEM As a result of earnestly examining in order to achieve the said objective, (A) hexagonal plate-shaped zinc oxide is excellent in the whitening effect of a tooth, and when it mix | blends it with the composition for oral cavity, it is excellent in making a tooth whiter than an original color. I found out that it has a whitening effect. That is, according to the present invention, by blending (A) hexagonal plate-shaped zinc oxide in the composition for oral cavity, it gives the whitening effect of the outstanding tooth, and by this, even if it is a normal toothbrush and a gargle only without using a fixing means, This is noticeable, the brightness of the teeth increases, and it has been found that the teeth can be seen to be whiter than the original colors, and the present invention has been achieved.

Although hexagonal zinc oxide is known as a compounding component of skin cosmetics, such as a foundation, as an ultraviolet inhibitor, the amorphous particle was generally used as a zinc oxide in the formulation applied to oral cavity. Therefore, the particle | grains of a single crystal do not apply as zinc oxide, and the compounding of hexagonal plate-shaped zinc oxide to the composition for oral cavity is not known until now. In contrast, in the present invention, (A) hexagonal plate-shaped zinc oxide, particularly preferably hexagonal plate-shaped zinc oxide having a specific average particle diameter and average thickness, exhibits a particularly excellent whitening effect of teeth in the composition for oral cavity, and other The use of a white pigment exhibits a special effect that is not obtained. Moreover, in this invention, not only said whitening effect but also a convergence feeling derived from zinc oxide can be appropriately provided by (A) component, and a favorable usability can also be provided.

Moreover, although the whitening technique of the tooth using zinc oxide which is a white pigment is known (patent document 3), as mentioned above, the zinc oxide used for the composition for oral cavity is an amorphous particle normally, Even if it is zinc oxide, an amorphous particle If it is, the effect of this invention cannot be acquired. As also shown in the comparative examples described later, in the case of using amorphous zinc oxide powder instead of the component (A), the whitening effect was inferior, and even in the case of hexagonal plate, the whitening effect was inferior. The effect drops.

In the present invention, although the detailed description of the mechanism of action is not clear, the contribution of the film-forming ability of the component (A) to the oral mucosa and the like contributes to the effect of whitening the teeth and imparting a sense of convergence satisfactorily. I guess that.

Therefore, this invention provides the following composition for oral cavity.

〔One〕

(A) A composition for oral cavity containing hexagonal plate-shaped zinc oxide.

〔2〕

The composition for oral cavity as described in [1] whose average particle diameter of a hexagonal plate-shaped zinc oxide is 0.1-10 micrometers.

[3]

The composition for oral cavity as described in [1] or [2] whose average thickness of a hexagonal plate-shaped zinc oxide is 0.01-1 micrometer.

〔4〕

The composition for oral cavity in any one of [1]-[3] whose average particle diameter / average thickness which shows the ratio of the average particle diameter and average thickness of hexagonal plate-shaped zinc oxide is 0.5-50.

[5]

The composition for oral cavity in any one of [1]-[4] which is a non-sheet form preparation containing 0.1-30 mass% of (A) components.

[6]

The composition for oral cavity as described in [5] which is a toothpaste or a gargle.

[7]

The composition for oral cavity in any one of [1]-[4] which is a sheet-form preparation containing 0.1-95 mass% of (A) components.

〔8〕

Furthermore, the composition for oral cavity in any one of [1]-[7] which contains 0.1-10 mass% of (B) surfactant.

[9]

The composition for oral cavity in any one of [1]-[8] which is for whitening of a tooth.

According to the present invention, it is possible to provide a composition for oral cavity excellent in whitening effect of teeth. The composition for oral cavity of this invention can be effectively used for whitening teeth by the point which can whiten teeth easily and effectively, and can make teeth appear whiter than an original color.

BRIEF DESCRIPTION OF THE DRAWINGS It is a two-dimensional image which shows the shape of (A) zinc oxide (hexagonal plate shape) used by the Example of this invention.

In this invention, (A) hexagonal plate-shaped zinc oxide is mix | blended with the composition for oral cavity as an active ingredient for whitening teeth.

(A) Hexagonal plate-shaped zinc oxide exhibits the whitening effect of a tooth, and gives a convergence feeling. The hexagonal plate-shaped zinc oxide is not limited as long as it is hexagonal and plate-shaped particles, and known monocrystalline hexagonal plate-shaped zinc oxide can be used. In addition, the hexagonal plate-shaped zinc oxide can be used by dispersing in water.

The average particle diameter of the hexagonal plate-shaped zinc oxide is preferably 0.1 µm or more, more preferably 0.5 µm or more, even more preferably 1 µm or more, particularly 1.5 µm or more, and further preferably 10 µm or less. 8 micrometers or less, More preferably, it is 5 micrometers or less. If it is 0.1 micrometer or more, the whitening effect will fully be exhibited. If it is 10 micrometers or less, a convergence feeling will fully be exhibited. The "particle diameter" of the hexagonal plate-shaped zinc oxide in this invention is an average value of the length of three diagonal lines of the hexagonal surface of a hexagonal plate-shaped particle.

The said average particle diameter was computed by image analysis, specifically, 20 hexagonal plate-shaped zinc oxides were selected at random, and measured and averaged the diagonal length of each particle, respectively. The scanning electron microscope (SEM) JSM7600F by a Nippon Denshi Corporation was used for the particle size measurement. The particle diameter of each particle measured and averaged the length of three diagonal lines of a hexagon from the image from a Z-axis direction (it is the same below).

The average thickness of the hexagonal plate-shaped zinc oxide is preferably 0.01 µm or more, more preferably 0.1 µm or more, still more preferably 0.2 µm or more, and preferably 1 µm or less, more preferably 0.8 µm or less. Preferably it is 0.7 micrometers or less. If the average thickness is 0.01 µm or more, the whitening effect is sufficiently exhibited. If it is 1 micrometer or less, a convergence feeling will fully be exhibited. The "thickness" of the hexagonal plate-shaped zinc oxide in the present invention is the distance between two hexagonal faces of the hexagonal plate-shaped particles.

The average thickness described above was randomly selected from 20 hexagonal plate-shaped zinc oxides using a scanning electron microscope (SEM) JSM7600F manufactured by Nippon Denshi Corporation, and the thickness of each particle was determined from an image from the Y-axis direction. It calculated by measuring and averaging. The thickness of each particle measured the distance (length) of the upper surface and lower surface of plate shape (it is the same below).

The hexagonal plate-shaped zinc oxide preferably has an average particle diameter / average thickness indicating a ratio of the above-described average particle diameter and average thickness, preferably 0.5 or more, more preferably 1 or more, even more preferably 2 or more, and 50 or less. More preferably, it is 30 or less and 5 or less may be sufficient. When the average particle diameter / average thickness is 0.5 or more, the whitening effect is sufficiently exhibited. If it is 50 or less, a convergence feeling is fully exhibited.

The oil absorption amount of the hexagonal plate-shaped zinc oxide is preferably 45 g / 100 g or less, and more preferably 36 g / 100 g or less. The oil absorption amount was measured according to JIS K-5101-13-1.

A commercial item can be used as such a hexagonal plate-shaped zinc oxide. For example, XZ-100F, XZ-300F, XZ-1000F, XZ-2000F, XZ-3000F (all are Sakai Chemical Industries, Ltd. make) etc. of hexagonal zinc oxide XZ series are mentioned.

(A) Although the compounding quantity of a hexagonal plate-shaped zinc oxide is not specifically limited, Preferably it is 0.1% (mass% or less) or more, especially 0.5% or more, especially 1% or more of the whole composition. Moreover, 95% or less of the whole composition is preferable, More preferably, it is 30% or less, Especially 20% or less, Especially 10% or less. If it is 0.1% or more, the whitening effect is fully exhibited, and a convergence feeling is fully exhibited. If it is not mix | blended too much, it can prevent that the own metal taste is expressed strongly, and can maintain a good feeling, and from this point, 95% or less is preferable.

Moreover, it can be manufactured as a composition for oral cavity in a general form, for example, non-sheet form, such as a toothpaste and a gargle. In such a non-sheet preparation, the blending amount of the component (A) is preferably from 0.1 to 30%, particularly from 0.1 to 20%, more preferably from 0.1 to 5%, even more preferably from 0.5 to 3%, especially Preferably it is 1.0 to 2%.

In addition, although the composition for oral cavity of this invention can be manufactured also in the form of sheets, such as a pack agent and a film agent, as mentioned later, in such a sheet-form preparation, it can mix | blend relatively many (A) component compositionally. In this case, although the compounding quantity of (A) component can be 0.1-95% of the whole composition from a viewpoint of a whitening effect and usability, 0.1-20% is preferable, More preferably, it is 0.1-5%.

In this invention, it is preferable to mix | blend surfactant (B) further. When (B) surfactant is mix | blended, the dispersibility of (A) component improves and a whitening effect becomes higher.

As surfactant, anionic surfactant, nonionic surfactant, amphoteric surfactant, etc. which are well-known for oral use are mentioned, Any may be sufficient. Specifically, as anionic surfactant, Alkyl sulfates, such as sodium lauryl sulfate, N-acyl sarcosinates, such as N-lauroyl sarcosin sodium, Acylamino acid salts, such as N-acyl glutamate, sodium alpha-olefin sulfonate, etc. Can be mentioned.

As the nonionic surfactant, average added moles of sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerol fatty acid esters such as monolaurate decaglyceryl, and ethylene oxide ( Fatty acid alkanolamide, such as polyoxyethylene fatty acid ester, such as polyoxyethylene hardened castor oil whose EO) is 10-60, polyoxyethylene higher alcohol ether, lauric acid ethanolamide, etc. are mentioned.

Examples of the amphoteric surfactant include betaine types such as alkyl betaine, alkyl dimethylamino acetate betaine, fatty acid amidopropyl betaine, fatty acid amidopropyldimethylamino acetate betaine, and betaine types such as alkyl imidazolinium betaine. And imidazoline types such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt.

Among these, anionic surfactants are particularly preferable, anionic surfactants having a sulfonic acid group are more preferable, and alkyl sulfates and α-olefinsulfonates are more preferable. In particular, sodium lauryl sulfate and sodium tetradecene sulfonate are preferable from the viewpoint of dispersibility of the component (A).

As for the compounding quantity of (B) surfactant, 0.1 to 10% of the whole composition is preferable, Especially preferably, it is 1 to 5%.

The composition for oral cavity of this invention can be made into the shape of liquid, solid, etc., such as paste form, a gel form, and liquid, and can be manufactured as toothpaste, such as a tube toothpaste, a liquid toothpaste, a liquid toothpaste, a gargle, etc. Moreover, it can also manufacture with the form which can be affixed to a tooth, specifically, a pack-like oral preparation, such as a pack agent and a film agent, without using a fixing means. In particular, a toothpaste or a gargle is preferable in view of the expression and usability of the present effect.

In addition, a pack agent is an agent which affixes the paste surface of a sheet | seat to a tooth, peels a support body, moves a paste to a tooth surface, and uses a paste as a toothpaste etc. here. A film agent is a formulation in which the whole film is used as a toothpaste etc. by affixing a film to a tooth surface and brushing it as it is. For example, it is the size and shape applicable to the tooth of about 2.5 cm in length, 2 cm in width, and about 0.3 mm in thickness. It can manufacture.

In this case, according to the purpose, formulation, etc. of a composition, the component normally mix | blended well-known for the oral composition besides the component mentioned above can be mix | blended as needed, and can be manufactured by the conventional method according to the form. For example, an abrasive, a thickening agent, a caking additive, a sweetening agent, a preservative, a coloring agent, a fragrance | flavor, active ingredients other than (A) component, etc. can be mix | blended. In addition, in the sheet agent, various gelling agents can also be used for the purpose of gelling and pasting to improve the applicability to the teeth and the adhesion to the teeth.

Examples of the abrasive include silica-based abrasives such as precipitated silica, aluminosilicates, and zirconosilicates, calcium phosphate-based abrasives, calcium carbonate and the like (compounds are usually 2 to 50%, particularly 10 to 40%).

Examples of the humectant (the viscous agent) include polyhydric alcohols such as sugar alcohols such as sorbet and xylite, glycerin, propylene glycol, and polyethylene glycols having an average molecular weight of 160 to 4000 (average molecular weight described in quasi-drug raw material standard 2006). Silver is usually 5 to 50%).

Examples of the caking agent include cellulose derivatives such as sodium carboxymethyl cellulose, hydroxyethyl cellulose and hydroxypropyl cellulose, alginic acid such as sodium alginate or derivatives thereof, gums such as xanthan gum, carrageenan, polyvinyl alcohol and sodium polyacrylate. And inorganic binders such as organic binders, gelling silicas, gelling aluminum silicas, gums, and laponites (compound amount is usually 0.1 to 10%).

Examples of the sweetening agent include sodium saccharin and benzoic acid such as methyl paraoxybenzoate, benzoic acid such as sodium benzoate, salts thereof and the like.

As a coloring agent, Blue No. 1, Yellow No. 4, titanium dioxide, etc. are mentioned.

As a fragrance, peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime oil , Lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, oregano oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweet oil, Natural flavors such as citron oil, iris concrete, absolute peppermint, absolute salt, orange flower, etc., or those processed by processing such natural flavors (current cut, wake cut, fractionation, liquid extract, essence, powder flavor, etc.) And menthol, carbon, anetol, cineol, methyl salicylate, cinnamicaldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, mentone , Menthyl acetate, N-substituted-para Mentan-3-carboxamide, pinene, octylaldehyde, citral, pullegon, carbyl acetate, anisealdehyde, ethyl acetate, ethyl butyrate, allylcyclohexanepropionate, methyl anthranilate, ethylmethylphenyl glycidate, Single flavors such as vanillin, undecaractone, hexanal, butanol, isoamyl alcohol, hexenol, dimethylsulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, ethylthioacetate, and also strawberry flavors and apple flavors Known fragrance materials used in oral compositions such as banana flavors, pineapple flavors, grape flavors, mango flavors, butter flavors, milk flavors, fruit mix flavors, and tropical fruit flavors can be used in combination. Although the compounding quantity is not specifically limited, Usually, 0.000001 to 1% is preferable in said fragrance | flavor raw material, and 0.1-2% is preferable in fragrance | flavor for fragrance using the said fragrance raw material.

Examples of the active ingredient include fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate, cationic fungicides such as isopropylmethylphenol and cetylpyridinium chloride, enzymes such as anti-inflammatory agents and dextranase, water-soluble phosphoric acid compounds and copper compounds. , Vitamins, plant extracts, tartar preventives, jigsaw preventives and the like. An active ingredient can be mix | blended in an effective amount in the range which does not prevent the effect of this invention.

In the case of producing a sheet-like preparation for oral cavity, the same material as the above-mentioned binder may be used as the gelling agent, but from the viewpoint of the usability in the oral cavity, sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose Cellulose derivatives, polyvinyl alcohol, and sodium alginate are preferable (the compounding quantity is preferably 1 to 5%).

In the present invention, the sheet-like oral preparation is not particularly limited as long as it can be applied to a tooth, and may be applied to one or two or more tooth surfaces. It can also be used as a toothpaste by affixing on a tooth surface and brushing as it is after use.

Moreover, it is preferable that the pack agent is integrally extended and integral with the paste composition so that peeling is possible on a support body. As a support body, it is preferable to use what is a water-insoluble material, and a film, nonwoven fabric, woven fabric, and mesh cloth of materials, such as a polypropylene, polyethylene, and polyurethane, are mentioned. The film may be a single layer or a laminated film, or a laminated sheet of a film, a nonwoven fabric, a woven fabric, or a mesh cloth. Moreover, you may coat a peeling liner and protect paste composition. These can use a commercial item.

Example

Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not limited to the following Example. In addition, in the following example,% represents the mass% unless there is particular notice.

[Example, Comparative Example]

The aqueous dispersion (simple system) of the composition shown to Table 1, 2, the toothpaste, the gargle, the pack agent, or the film (formulation system) of the composition shown to Tables 3-7 are each manufactured by a conventional method, and the method shown below Evaluated. The results are listed in the table.

The detailed description of the raw material used is shown below.

(A) zinc oxide (hexagonal);

Hexagonal plate-shaped zinc oxide XZ series (XZ-100F, 300F, 1000F, 2000F, 3000F), manufactured by Sakai Chemical Industries, Ltd., monocrystalline

XZ-100F: average particle diameter 0.1 mu m, average thickness 0.03 mu m, oil absorption 42 g / 100 g

XZ-300F: Average particle size 0.3㎛, average thickness 0.08㎛, oil absorption 37g / 100g

XZ-1000F: Average particle size 1 μm, average thickness 0.3 μm, oil absorption 36 g / 100 g

XZ-2000F: average particle diameter 2㎛, average thickness 0.5㎛, oil absorption 34g / 100g

XZ-3000F: Average particle size 3㎛, average thickness 0.8㎛, oil absorption 32g / 100g

These raw materials were appropriately classified and used for the experiment. The average particle diameter and average thickness of the used sample are shown in the table, respectively.

Zinc oxide (powdered, comparative);

Amorphous powder, Japan Pharmacopoeia zinc oxide, Sakai Chemical Industries, Ltd., amorphous

Average particle diameter 2㎛, average thickness 2㎛, oil absorption 59g / 100g

Mica titanium (hexagonal, comparative);

TIMIRON MP-149, made by Merck, monocrystalline,

Average particle diameter 2㎛, average thickness 0.5㎛

The measuring method of said average particle diameter and average thickness is shown below.

Measuring method of average particle diameter;

It calculated by image analysis, measured and analyzed similarly to the above using the scanning electron microscope (SEM) JSM7600F by Nippon Denshi Corporation, and calculated | required. The length of the three diagonal lines of the hexagon was measured from the image from the Z-axis direction, and was made into the particle size, and the average particle diameter was computed.

Measuring method of average thickness;

It measured similarly to the above using the scanning electron microscope (SEM) JSM7600F by a Nippon Denshi Corporation, and calculated | required the average value. The length of the plate-shaped upper surface and lower surface of particle | grains was measured, it was made thickness, and average thickness was computed.

In addition, the measurement methods of the average particle diameter and average thickness of zinc oxide (hexagonal plate shape) and mica titanium (hexagonal plate shape) were as above-mentioned, respectively, and the average particle diameter of zinc oxide (powder shape) is the laser made by Horiba Seisakusho Co., Ltd. It measured with the diffraction scattering particle size distribution analyzer LA-920, and since the shape of a zinc oxide (powder form) was close to spherical shape, the average particle diameter was made into the average thickness for convenience.

The oil absorption amount was measured according to JIS K-5101-13-1.

Moreover, (A) two-dimensional image (photographing using the scanning electron microscope (SEM) JSM7600F made from Nippon Denshi Corporation) of zinc oxide (hexagonal plate shape) is shown in FIG.

Evaluation method-1: The brightness measurement method of the hydroxyapatite (HAP) board, and the evaluation method of the degree of heat (simple system)

Zinc oxide was weighed and dispersed in 100 ml of water. In this dispersion, a hydroxyapatite (HAP) plate having a diameter of 7 mm was put, and after 3 minutes, the HAP plate was taken out and rinsed lightly with 100 ml of water. This HAP plate was measured with the color difference meter (spectral color difference meter SE-2000, the Nippon Denshoku Kogyo Co., Ltd. product), and the value of (DELTA) L which is an index of the brightness was obtained. As a control, untreated articles (untreated HAP plates) were similarly measured. The comparative example was similarly measured according to the said method.

In addition, 10 subjects were questionnaire about the degree of deflection of the HAP plate. The rating (1-4 points) was given based on the following rating criteria, and the average value was computed from the obtained result. From the average value of the computed ratings, the degree of K of a HAP board was evaluated based on the following evaluation criteria. Untreated HAP plates were also used as controls.

(Rating standard)

4 points: very white

3 points: whiten

2 points: slightly whitened

1 point: not whitening

〔Evaluation standard〕

☆: 3.5 points or more

(Double-circle): Average value 3.0 points or more and less than 3.5 points

(Circle): Average value 2.5 points or more and less than 3.0 points

(Triangle | delta): An average value 2.0 or more and less than 2.5 points

×: less than 2.0 points

Evaluation method-2: The measuring method of the brightness of the hydroxyapatite (HAP) plate, and the evaluation method of the degree of heat (processing system)

Toothpaste, pack (paste), and film were diluted three times with water, and a dispersion of about 100 ml was prepared to obtain an evaluation solution. The gargle agent was made into the evaluation liquid as it was. In this dispersion, a hydroxyapatite (HAP) plate having a diameter of 7 mm was put, and after 3 minutes, the HAP plate was taken out and rinsed lightly with 100 ml of water. This HAP plate was measured with the color difference meter (spectral color difference meter SE-2000, the Nippon Denshoku Kogyo Co., Ltd. product), and the value of (DELTA) L which is an index of the brightness was obtained. As a control, untreated articles (untreated HAP plates) were similarly measured. The comparative example was similarly measured according to the said method.

In addition, in the same manner as in Evaluation Method-1, the degree of roughness of the HAP plate was evaluated.

Evaluation method-3: Evaluation method of feeling of convergence (system)

Ten subjects were asked about the height of the feeling of convergence after using each formulation. The rating (1-4 points) was given based on the following rating criteria, and the average value was computed from the obtained result. From the average value of the computed ratings, it evaluated about the height of the feeling of convergence after brushing based on the following evaluation criteria.

In the toothpaste, the toothpaste was performed by taking about 1 g of the toothpaste composition into the toothbrush, brushing for 3 minutes, and then rinsing the oral cavity with water in each subject. Other formulations were each used in a conventional manner.

(Rating standard)

4 points | pieces: A feeling of convergence is high

3 points: Feeling convergence

2 points: A little convergence

1 point: no convergence

〔Evaluation standard〕

☆: 3.5 points or more

(Double-circle): Average value 3.0 points or more and less than 3.5 points

(Circle): Average value 2.5 points or more and less than 3.0 points

(Triangle | delta): An average value 2.0 or more and less than 2.5 points

×: less than 2.0 points

**; A pack agent was manufactured in the same shape by the method similar to the sticking sheet of the Example of Unexamined-Japanese-Patent No. 2016-117682 except using the paste composition of the said composition, and a support body. The paste composition was applied to the support, and spread over the silicone coating surface of the support and the release liner (BD New Haku of Film Vier 75E-001 manufactured by Fujimori Kogyo Co., Ltd.). The obtained sheet was removed from the mold in the sizes of the maxillary (width width (parallel to parallel)) 62 mm and the longitudinal width (24 mm) and the mandibular (52 mm width and 24 mm vertical width), and cuts and fold lines were also produced. After sticking a pack agent to a tooth surface and peeling a support body, it brushed and used as it is.

***; The film was manufactured by the usual method at length of 2.5 cm, width 2 cm, and thickness of 0.3 mm. After affixing a film agent to a tooth surface, it brushed as it was and used.

Claims (9)

(A) A composition for oral cavity containing hexagonal plate-shaped zinc oxide. The composition for oral cavity of Claim 1 whose average particle diameter of hexagonal plate-shaped zinc oxide is 0.1-10 micrometers. The composition for oral cavity of Claim 1 or 2 whose average thickness of hexagonal plate-shaped zinc oxide is 0.01-1 micrometer. The composition for oral cavity of any one of Claims 1-3 whose average particle diameter / average thickness is 0.5-50 which shows the ratio of the average particle diameter and average thickness of hexagonal plate-shaped zinc oxide. The composition for oral cavity of any one of Claims 1-4 which is a non-sheet form preparation containing 0.1-30 mass% of (A) component. The composition for oral cavity of Claim 5 which is a toothpaste or a gargle. The composition for oral cavity of any one of Claims 1-4 which is a sheet-like preparation containing 0.1-95 mass% of (A) component. The composition for oral cavity of any one of Claims 1-7 which contains 0.1-10 mass% of (B) surfactant further. The composition for oral cavity of any one of Claims 1-8 for whitening of a tooth.

Images