CN110198699A - Composition for oral cavity - Google Patents
Composition for oral cavity Download PDFInfo
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- CN110198699A CN110198699A CN201880007910.9A CN201880007910A CN110198699A CN 110198699 A CN110198699 A CN 110198699A CN 201880007910 A CN201880007910 A CN 201880007910A CN 110198699 A CN110198699 A CN 110198699A
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- composition
- oral cavity
- zinc oxide
- tooth
- oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0254—Platelets; Flakes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
A kind of composition for oral cavity, which is characterized in that contain (A) hexagon plate zinc oxide.In accordance with the invention it is possible to provide tooth whitening effect excellent composition for oral cavity.
Description
Technical field
The present invention relates to the composition for oral cavity that tooth whitening (brightens) excellent effect.
Background technique
In the past, as the tooth chemistry whitening technology for making tooth seem whiter than original color, propose as
Under scheme.
(1) tooth whitening of bleaching agent is used.
(2) skin-whitening composition of chelating agent, specifically polyphosphate etc. will have been used to keep using mean for applying, is fixed
Tooth whitening (the patent document 1 carried out on tooth；Japanese Unexamined Patent Publication 2000-281548 bulletin).
(3) the non-aqueous system: compositions of specific solvent and copolymer will have been used to be removably mountable to by using mean for applying
Tooth whitening (the patent document 2 carried out on tooth；Japanese Unexamined Patent Publication 2006-8530 bulletin).
(4) composition containing white powders such as titanium dioxide, silica, zinc oxide is mounted on tooth using mean for applying
It is upper or modulate film-forming agents and be fitted on tooth, the method that seems to whiten to fixed white powder (patent document 3:
No. 483155 bulletins of Japanese Patent No.；Patent document 4: Japanese Unexamined Patent Publication 2008-1649 bulletin).
Existing technical literature
Patent document
[patent document 1] Japanese Unexamined Patent Publication 2000-281548 bulletin
[patent document 2] Japanese Unexamined Patent Publication 2006-8530 bulletin
No. 483155 bulletins of [patent document 3] Japanese Patent No.
[patent document 4] Japanese Unexamined Patent Publication 2008-1649 bulletin
Summary of the invention
Problems to be solved by the invention
However, (1) is in secure context, there are problems, in addition, also using sometimes for tooth whitening in (2)~(4)
Fixed mechanism, therefore there are rooms for improvement in terms of simplicity, it is desirable to develop easier and effective tooth whitening technology.
The present invention has been made in view of the above-described circumstances, and an object thereof is to provide the oral cavity groups that tooth whitening effect is excellent
Close object.
A technical solution to solve project
The inventors of the present invention have made intensive studies to achieve the goals above, as a result, it has been found that, the oxidation of (A) hexagon plate
Zinc is excellent in terms of tooth whitening effect, if be cooperated in composition for oral cavity, having makes tooth than original face
The excellent whitening effect of Se Gengbai.That is, in accordance with the present invention, it was found that by cooperating (A) hexagon plate in composition for oral cavity
Zinc oxide can assign excellent tooth whitening effect, though without using fixing means and only brushed teeth as a result, by conventional and
Gargle, the whiteness of tooth is also significant, and the brightness of tooth also increases, so as to so that tooth compared with original color especially
It is white, so as to complete the present invention.
The zinc oxide of known hexagon plate is used as UV resistant agent to be synthesized matching for the skin cosmetics such as foundation cream
Point, still, applied to intraoral preparation usually using the amorphous particle of zinc oxide.Therefore, zinc oxide is not applied specially
Monocrystal particle but into composition for oral cavity cooperate hexagon plate zinc oxide scheme be still unknown.In contrast, at this
In invention, (A) hexagon plate zinc oxide, particularly preferably the hexagon plate with specific average grain diameter and average thickness
Zinc oxide plays especially excellent tooth whitening effect in composition for oral cavity, and playing can not when using other white pigments
Obtained function and effect outstanding.In turn, in the present invention, above-mentioned whitening effect can not only be assigned by (A) ingredient, moreover it is possible to
It is enough moderately to assign the convergence sense for being originated from zinc oxide, to assign good use feeling.
It should be noted that the tooth whitening technology of the zinc oxide used as white pigment is well known (patent document 3), such as
Upper described, the zinc oxide for composition for oral cavity is usually amorphous particle, in the feelings of the zinc oxide as amorphous particle
Under condition, function and effect of the invention cannot be obtained.Shown in comparative example as be described hereinafter, replaced using unbodied Zinc oxide powder
(A) in the case where ingredient, whitening effect is poor, in addition, using being the mica titanium of hexagon plate, whitening effect
Difference, when using these, function and effect of the invention are poor.
Detailed mechanism of action of the invention is still not clear, but it is presumed that, pass through the film forming ability of (A) ingredient, Yi Jiyou
Help rest on oral mucosa etc., thus the excellent effect for making tooth seem to whiten, additionally it is possible to sufficiently assign convergence sense.
Therefore, the present invention provides following composition for oral cavity.
〔1〕
A kind of composition for oral cavity, which is characterized in that contain (A) hexagon plate zinc oxide.
〔2〕
Composition for oral cavity as described in [1], wherein the average grain diameter of hexagon plate zinc oxide is 0.1~10 μm.
〔3〕
Composition for oral cavity as described in [1] or [2], wherein the average thickness of hexagon plate zinc oxide is 0.01~1 μm.
〔4〕
Composition for oral cavity as described in any one of (1)~(3), wherein indicate the average grain diameter of hexagon plate zinc oxide
Average grain diameter/average thickness with the ratio of average thickness is 0.5~50.
〔5〕
Composition for oral cavity as described in any one of [1]~[4] is the non-slice of (A) ingredient containing 0.1~30 mass %
Shape preparation.
〔6〕
Composition for oral cavity as described in [5] is dentifrice or collutory.
〔7〕
Composition for oral cavity as described in any one of [1]~[4] is the sheet of (A) ingredient containing 0.1~95 mass %
Preparation.
〔8〕
Composition for oral cavity as described in any one of [1]~[7] contains 0.1~10 mass % of (B) surfactant.
〔9〕
Composition for oral cavity as described in any one of [1]~[8], is used for tooth whitening.
Invention effect
In accordance with the invention it is possible to provide tooth whitening effect excellent composition for oral cavity.Oral composition of the invention
Object can easily and efficiently tooth-whitening, seem tooth than original white color, therefore tooth beauty can be effectively served as
White purposes.
Detailed description of the invention
Fig. 1 is the two dimensional image for indicating the shape of (A) zinc oxide (hexagon plate) used in the embodiment of the present invention.
Specific embodiment
In the present invention, (A) hexagon plate zinc oxide is matched with oral cavity as the effective component for tooth-whitening
With in composition.
(A) hexagon plate zinc oxide plays tooth whitening (brightening) effect, in addition, assigning convergence sense.Hexagon plate
As long as the particle of zinc oxide hexagon shape and plate, to its type etc., there is no limit can be used well known hexagon
Plate Zinc oxide single crystal.
It should be noted that hexagon plate zinc oxide can be dispersed in water use.
The average grain diameter of hexagon plate zinc oxide is preferably 0.1 μm or more, more preferably 0.5 μm or more, further excellent
1 μm or more, especially preferably 1.5 μm or more are selected as additionally, it is preferred that for 10 μm hereinafter, more preferably 8 μm hereinafter, further preferably
It is 5 μm or less.If 0.1 μm or more, then whitening effect can be given full play to.When being 10 μm or less, convergence sense can be fully played.
" partial size " of hexagon plate zinc oxide in the present invention refers to that 3 of the hexagon shape plane of hexagon shape platy particles are diagonal
The average value of the length of line.
Above-mentioned average grain diameter is calculated by image analysis, specifically, being randomly chosen 20 hexagon plate oxidations
Zinc measures cornerwise length of each particle and is averaged, respectively to calculate.Particle size determination is made using Japan Electronics (strain)
Scanning electron microscope (SEM) JSM7600F.The partial size of each particle is that the 3 of hexagon is measured from from the image of Z-direction
The cornerwise length of item is simultaneously averaged (following same).
The average thickness of hexagon plate zinc oxide is preferably 0.01 μm or more, more preferably 0.1 μm or more, further excellent
It is selected as 0.2 μm or more, additionally, it is preferred that for 1 μm hereinafter, more preferably 0.8 μm hereinafter, further preferably 0.7 μm or less.It is average
When with a thickness of 0.01 μm or more, whitening effect can be fully played.When being 1 μm or less, convergence sense can be fully played.The present invention
In hexagon plate zinc oxide " thickness " refer to hexagon shape platy particles two hexagon planes distance.
It should be noted that above-mentioned average thickness calculates as follows: the scanning electron microscope (SEM) made using Japan Electronics (strain)
JSM7600F is randomly chosen 20 hexagon plate zinc oxide, the thickness of each particle is measured from from the image of Y direction
And it is averaged and calculates.The thickness of each particle is that the upper surface of measurement plate is (following obtained by (length) at a distance from lower surface
Equally).
Hexagon plate zinc oxide, indicate the average grain diameter of the ratio of above-mentioned average grain diameter and average thickness/average thickness
Degree preferably 0.5 or more, more preferably 1 or more, further preferably 2 or more, additionally, it is preferred that for 50 or less, more preferably 30
Hereinafter, can be 5 or less.When average grain diameter/average thickness is 0.5 or more, whitening effect can be given full play to.If 50 hereinafter,
It then can fully play convergence sense.
In addition, the oil absorption of hexagon plate zinc oxide is preferably 45g/100g hereinafter, more preferably 36g/100g or less.
Oil absorption is measured according to JISK-5101-13-1.
As such hexagon plate zinc oxide, commercially available product can be used.Such as it can enumerate: the oxidation of hexagon plate
XZ-100F, XZ-300F, XZ-1000F, XZ-2000F, XZ-3000F (being Sakai chemical industry (strain) system) of zinc XZ series etc..
(A) use level of hexagon plate zinc oxide is not particularly limited, preferably 0.1% (matter of composition entirety
% is measured, same as below) more than, particularly preferably 0.5% or more, especially preferably 1% or more.Additionally, it is preferred that whole for composition
The 95% of body is hereinafter, more preferably 30% hereinafter, particularly preferably 20% hereinafter, especially preferably 10% or less.If 0.1%
More than, then whitening effect can be given full play to, in addition, fully playing convergence sense.If but polygamy closes, it can be prevented
The metallic taste of itself consumingly shows, is well maintained use feeling, in this regard can be 95% or less.
In turn, aschistic shape such as gross morphology of composition for oral cavity, such as dentifrice, collutory can be prepared as
State.In such non-Formulation, the use level of (A) ingredient is preferably whole 0.1~30% of composition, particularly preferably
0.1~20%, more preferably 0.1~5%, further preferably 0.5~3%, especially preferably 1.0~2%.
In addition, as described later, composition for oral cavity of the invention can also be prepared as face film agent (Japanese: パ ッ Network drug), film etc.
The form of sheet, but in such Formulation, (A) ingredient can be cooperated more on composition.At this point, from whitening effect
From the perspective of use feeling, the use level of (A) ingredient can be set to composition it is whole 0.1~95%, preferably 0.1~
20%, more preferably 0.1~5%.
In the present invention, it is preferred to further cooperate (B) surfactant.When cooperating (B) surfactant, (A) ingredient
Dispersibility improves, and whitening effect further increases.
As surfactant, the well known anionic surfactant as oral cavity, non-ionic table can be enumerated
Face activating agent, amphitypy surfactant etc., any one.Specifically, can be enumerated as anionic surfactant
The acyls such as the N- acyl sarcosinates such as the alkyl sulfates such as NaLS, N- sodium lauroyl sarcosine, N- acyl glutamate
Base amino-acid salt, alpha-olefin sodium sulfonate etc..
As nonionic surface active agent, the sugar fatty acid esters such as sucrose fatty ester, sugar alcohol fatty acid ester, sorbose can be enumerated
The average addition of the polyglyceryl fatty acid esters, ethylene oxide such as alcohol acid anhydride aliphatic ester, fatty acid glyceride, ten glyceride of mono laurate
Polyoxyethylene fatty acid esters such as Crodaret that molal quantity (E.O.) is 10~60, polyoxyethylene higher alcohol ether,
Fatty acid alkanol amides such as lauric acid diethyl amide etc..
As amphitypy surfactant, alkyl betaine, alkyl dimethyl oxyneurine, fatty acid amide third can be enumerated
Acetic acid betaine type, the alkyl imidazoline glycine betaines such as base glycine betaine, fatty acid amide propyl dimethylaminoethyl acid glycine betaine etc.
The imidazoline types such as betaine type, N- fatty acid acyl-N- carboxymethyl-N- hydroxyethyl ethylene diamine salt.
Wherein, particularly preferred anionic surfactant more preferably has sulfonic anionic surfactant, more excellent
Select alkyl sulfate, alpha-alkene sulfonate.From the viewpoint of the dispersibility of (A) ingredient, particularly preferred NaLS, ten
Four carbene sodium sulfonates.
(B) use level of surfactant is preferably whole 0.1~10%, particularly preferably 1~5% of composition.
The shapes such as the liquids such as paste, gel, liquid, solid, Ke Yizuo can be made in composition for oral cavity of the invention
It is prepared for dentifrices, the collutories such as toothpaste, liquid dentifrice, liquid dentifrice etc..In turn, it can also be prepared into even if not making
The oral preparations of form on tooth, specifically sheets such as face film agent, film can also be fitted in fixing means.It is special
It is not preferably dentifrice or collutory from the viewpoint of the expression power of this effect, usability.
It should be noted that here, face film agent is that the lotion dignity of sheet material is fitted on tooth to remove supporter, by lotion turn
It moves on on the flank of tooth, lotion is used as to the preparation of dentifrice etc..So-called film is by the way that film is attached at the flank of tooth and is directly ground
The preparation brushed and be integrally used as dentifrice etc. to use film, such as can be prepared into and can be applied to vertical 2.5cm, horizontal 2cm, thickness
Size, the shape of the tooth of 0.3mm or so.
At this point, according to the purpose of composition, dosage form etc. in addition to the above ingredients, conduct can also be cooperated as needed
The ingredient that composition for oral cavity is generally mated well known to can be prepared by usual way corresponding with form etc..Example
Such as, can cooperate other than grinding agent, adhesion agent, binder, sweetener, preservative, colorant, fragrance, (A) ingredient it is effective at
Point etc..In addition, in tablets, for gelation, gelatinization and improve the purpose to the coating of tooth or with the adherence of tooth,
Also various gelling agents can be used.
As grinding agent, settleability silica, alumina silicate, zirconium silicate (Japanese: ジ Le U ノ シ リ ケ ー can be enumerated
ト) etc. silica-based grinding agent, series of calcium phosphate grinding agent, calcium carbonate etc. (use level is usually 2~50%, especially 10~
40%).
As wetting agent (adhesion agent), the sugar alcohols such as D-sorbite, xylitol, glycerol, propylene glycol, mean molecule can be enumerated
Polyalcohols (the use levels such as the polyethylene glycol of amount 160~4000 (average molecular weight that medicine part outer article raw material standard 2006 is recorded)
Usually 5~50%).
As binder, such as sodium carboxymethylcellulose, hydroxyethyl cellulose, the fibres such as hydroxypropyl cellulose can be enumerated
Tie up alginic acids such as plain derivative, sodium alginate or derivatives thereof, the colloids such as xanthan gum class, carrageenan, polyvinyl alcohol, polypropylene
The organic binders such as sour sodium, (use level is logical for the inorganic binders such as gelation silica, gelation alumina silicate, propolis, montmorillonite
It is often 0.1~10%).
As sweetener, saccharin sodium etc. can be enumerated, as preservative, methyl p-hydroxybenzoate etc. can be enumerated to hydroxyl
The benzoic acid such as yl benzoic acid ester, sodium benzoate or its salt etc..
As colorant, blue 1, yellow 4, titanium dioxide etc. can be enumerated.
As fragrance, peppermint oil, spearmint oil, oleum anisi, eucalyptus oil, wintergreen, oil of bay, caryophyllus oil, hundred can be used
In careless oil, sage oil, lemon oil, orange-seed oil, asia peppermint oil, cardamom oil, coriander oil, mandarin oil, limette oil, lavender
Oil, rosemary oil, oreodaphene, yellow chamomile, caraway oil, marjoram oil, laurin oil, lemongrass oil, origanum oil, pine needle oil,
Neroli oil, attar of roses, jasmine oil, oil of grapefruit, sweetieoil, grape-fruit seed oil, concrete of iris oil, Peppermint essential oil, rose essential oil,
The natural perfume material of orange caul-fat etc. and these natural perfume materials working process (it is preceding evaporate portion, after evaporate portion, fractionation, liquid-liquid extraction, essence
Inhibition and generation, powder perfume etc.) fragrance and menthol, carboxylic acid, anethole, cineole, gaultherolin, cinnamic acid, Ding Zi
Fragrant phenol, 3-l- menthoxypropane -1,2- glycol, thymol, linalool, linalyl-acetate, limonene, menthones, acetic acid
Menthyl ester, N- substitution-are to terpane -3- carboxylic acid amides, sobrerone, octyl aldehyde, citral, pulegone, carvacryl acetate, fennel
Aldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionic ester, methyl anthranilate, ethyl methyl phenyl glycidol
Acid esters, vanillic aldehyde, undecalactone, hexanal, butanol, isoamyl alcohol, hexanal, dimethylsulphide, ring dulcin, furfural, trimethyl pyrrole
Strawberry flavor, apple spice, banana incense can also be applied in combination in the single-items fragrance such as piperazine, methyl lactate, ethylenebis dithiocarbamate acetic acid esters
Material, pineapple flavors, grape flavor, mango fragrance, butter aroma, milk fragrance, fruit potpourri, tropical fruit (tree) fragrance etc. are adjusted
With fragrance etc., for the well known spice raw material of composition for oral cavity.Use level is not particularly limited, and usually above-mentioned fragrance is former
It is preferably 0.000001~1% in the case where material, the case where in addition imparting using the fragrance of above-mentioned spice raw material with fragrance
It is down preferably 0.1~2%.
As effective component, the fluorochemicals such as sodium fluoride, sodium monofluorophosphate, isopropyl methyl phenol, chlorine can be enumerated
Change enzymes, water-soluble phosphate cpd and the copper such as cationics fungicide, anti-inflammatory agent, the dextranases such as cetyl pyridinium
Close object, vitamins, plant extracts, calculus dentalis preventing agent, tartar preventing agent etc..Effective component can not interfere the present invention
Effect in the range of cooperate effective quantity.
In the oral preparations for preparing slabbing, as gelating agent, can be used same as above-mentioned binder
Substance, from the use feeling aspect in mouth, preferably sodium carboxymethylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose
Equal cellulose derivatives, polyvinyl alcohol, sodium alginate (use level is preferably 1~5%).
In the present invention, for the oral preparations of sheet, as long as tooth can be suitable for, to its shape, thickness etc.
Shape, usage mode etc. are not particularly limited, and can be the form that can be fitted on 1 or 2 or more facing, in addition,
Facing can be fitted in and use is directly brushed teeth later, to be used as dentifrice.
Paste composition and integration it should be noted that face film agent strippingly extends preferably on supporter.As support
Body, it is preferable to use the material of water-insoluble supporter, the film or nonwoven of the materials such as polypropylene, polyethylene, polyurethane can be enumerated
Cloth, woven fabric, screen cloth.The laminates of single layer or stacked film or film and non-woven fabrics, woven fabric, screen cloth can be used in above-mentioned film.Into
And release liner can also be coated to protect paste composition.Commercially available product can be used in they.
[embodiment]
Hereinafter, showing embodiment and comparative example, the present invention is specifically described, but the present invention is not limited to following realities
Apply example.It should be noted that unless otherwise specified, then % indicates quality % in following examples.
[embodiment, comparative example]
Cleaning the teeth for composition shown in the aqueous dispersions (Simple System) formed shown in table 1,2, table 3~7 is conventionally prepared respectively
Agent, collutory, face film agent or film (preparation system), the method shown in following is evaluated.Result is remembered in table together.
It is as follows using the details of raw material.
(A) zinc oxide (hexagon plate)；
Hexagon plate zinc oxide XZ serial (XZ-100F, 300F, 1000F, 2000F, 3000F), Sakai chemical industry (strain) system,
Monocrystalline
XZ-100F: 0.1 μm of average grain diameter, 0.03 μm of average thickness, oil absorption 42g/100g
XZ-300F: 0.3 μm of average grain diameter, 0.08 μm of average thickness, oil absorption 37g/100g
XZ-1000F: 1 μm of average grain diameter, 0.3 μm of average thickness, oil absorption 36g/100g
XZ-2000F: 2 μm of average grain diameter, 0.5 μm of average thickness, oil absorption 34g/100g
XZ-3000F: 3 μm of average grain diameter, 0.8 μm of average thickness, oil absorption 32g/100g
These raw materials are suitably classified, for testing.The average grain diameter and average thickness of used sample are shown in table.
Zinc oxide (powdered, compare product)；
Unbodied powder, Japanese Pharmacopoeia zinc oxide, Sakai chemical industry (strain) are made, are amorphous,
2 μm of average grain diameter, 2 μm of average thickness, oil absorption 59g/100g mica titanium (hexagon plate compares product)；
TIMIRONMP-149, the manufacture of Merck (Merck) company, monocrystalline,
2 μm of average grain diameter, 0.5 μm of average thickness
Above-mentioned average grain diameter, the measuring method of average thickness are as follows.
The measuring method of average grain diameter；
It is calculated by image analysis, scanning electron microscope (SEM) JSM7600F made using Japan Electronics (strain), and it is above-mentioned same
It is measured to sample, parses and find out.According to 3 cornerwise length of the determining image hexagon shape from Z-direction, make
For partial size, average grain diameter is calculated.
The measuring method of average thickness；
Scanning electron microscope (SEM) JSM7600F made using Japan Electronics (strain), is measured in the same manner as described above measurement, found out
Average value.The upper surface of the plate of particle and the length of lower surface are measured, as thickness, calculates average thickness.
It should be noted that the average grain diameter of zinc oxide (hexagon plate) and mica titanium (hexagon plate), average thickness
Measuring method each as described above, is spread out in addition, the average grain diameter of zinc oxide (powdered) makes made laser by (strain) hole field
Scattering formula particle size distribution device LA-920 is penetrated to be measured, since the shape of zinc oxide (powdered) is close to spherical,
For convenience, average thickness is set as average thickness.
Oil absorption is measured according to JISK-5101-13-1.
In addition, by the two dimensional image (scanning electron microscope made using Japan Electronics (strain) of (A) zinc oxide (hexagon plate)
(SEM) JSM7600F is shot) it is shown in Fig. 1.
Evaluation method -1: the evaluation method of the degree of the brightness measuring method and whiteness of hydroxyapatite (HAP) plate is (simple
System)
Zinc oxide is measured, is scattered in 100ml water.Apatite hydroxide (HAP) plate of diameter 7mm, warp are added in the dispersion liquid
After spending 3 minutes, HAP plate is taken out, is gently washed with the water of 100ml.With colour difference meter (light splitting colour difference meter SE-2000, the electric color work of Japan
Industry (strain) system) the HAP plate is measured, obtain the value of the index Δ L of brightness.As control, it is (untreated similarly to measure untreated product
HAP plate).Comparative example is carried out similarly measurement according to the method described above.
In addition, carrying out questionnaire survey to the degree of the whiteness of HAP plate for 10 subjects.Based on following scoring benchmark, assign
It scores (1~4 point), average value is calculated by obtained result.The average value of scoring calculated, based on following evaluation bases
The degree of the whiteness of quasi- evaluation HAP plate.In addition, using untreated HAP plate as control.
[scoring benchmark]
4 points: very white
3 points: bleaching
2 points: slightly bleaching
1 point: not bleaching
[evaluation criteria]
☆: more than average value 3.5 divides
◎: average value 3.0 divides more than and less than 3.5 points
Zero: average value 2.5 divides more than and less than 3.0 points
△: average value 2.0 divides more than and less than 2.5 points
×: average value is less than 2.0 points
Evaluation method -2: the evaluation method (preparation of the degree of the brightness measuring method and whiteness of hydroxyapatite (HAP) plate
System)
For dentifrice, face film agent (lotion), film, sample is diluted to 3 times with water, makes the dispersion liquid of about 100ml, as
Evaluate liquid.Collutory is directly as evaluation liquid.Apatite hydroxide (HAP) plate of diameter 7mm is added in the dispersion liquid, by 3
After minute, HAP plate is taken out, is gently washed with the water of 100ml.With colour difference meter (light splitting colour difference meter SE-2000, the electric color industry of Japan
(strain) system) the HAP plate is measured, obtain the value of the index Δ L of brightness.As control, it is (untreated similarly to measure untreated product
HAP plate).Comparative example is carried out similarly measurement according to the method described above.
In addition, being evaluated in the same manner as evaluation method -1 degree of the whiteness of HAP plate.
Evaluation method -3: the evaluation method (preparation system) of sense is restrained
For 10 subjects, questionnaire survey is carried out to the degree for using the convergence sense after each preparation.Based on following scoring benchmark,
Scoring (1~4 point) is assigned, average value is calculated by obtained result.The average value of scoring calculated is commented based on following
Valence benchmark evaluates the degree of the convergence sense after polish-brush.
It should be noted that brushing teeth as follows in the case where dentifrice: in each subject, by Dentrifice composition about 1g
It is placed on toothbrush, after brushing teeth 3 minutes, is rinsed with water in oral cavity and implements.Other preparations conventionally use respectively.
[scoring benchmark]
4 points: feeling high convergence sense
3 points: feeling convergence sense
2 points: slightly feeling convergence sense
1 point: not feeling convergence sense
[evaluation criteria]
☆: more than average value 3.5 divides
◎: average value 3.0 divides more than and less than 3.5 points
Zero: average value 2.5 divides more than and less than 3.0 points
△: average value 2.0 divides more than and less than 2.5 points
×: average value is less than 2.0 points
[table 1]
Aqueous dispersions (simple system)
[table 2]
Aqueous dispersions (simple system)
*；The ratio of the average grain diameter of mica titanium, thickness and the two
[table 3]
Dentifrice
[table 4]
Dentifrice
*；The ratio of the average grain diameter of mica titanium, thickness and the two
[table 5]
Collutory
[table 6]
Face film agent**
**；Face film agent is other than using the paste composition of above-mentioned composition, supporter, with Japanese Unexamined Patent Publication 2016-117682
The adhesive piece of the embodiment of bulletin is prepared into same shape by the same method.Paste composition is coated on supporter,
It is pressed from both sides on one side with the silicone coated face of supporter and release liner (BD of the film バ イ Na 75E-001 of rattan lumber industry (strain) system is milky white)
Enter, extends on one side.By obtained sheet material maxilla (width (method parallel with denture) 62mm, vertical width 24mm), lower jaw
It is punched with the size of (width 52mm, vertical width 24mm), produces notch and turn-line.Face film agent is attached at the flank of tooth and is shelled
After supporter, directly brushes teeth and use.
[table 7]
Film***
***；Film is prepared as the size of vertical 2.5cm, horizontal 2cm, thickness 0.3mm by usual way.Film is fitted in into the flank of tooth
Later, it directly brushes teeth and uses.
Claims (9)
1. a kind of composition for oral cavity, which is characterized in that contain (A) hexagon plate zinc oxide.
2. composition for oral cavity as described in claim 1, wherein the average grain diameter of hexagon plate zinc oxide is 0.1~10 μ
m。
3. composition for oral cavity as claimed in claim 1 or 2, wherein the average thickness of hexagon plate zinc oxide is 0.01
~1 μm.
4. composition for oral cavity according to any one of claims 1 to 3, wherein indicate the flat of hexagon plate zinc oxide
Average grain diameter/average thickness of the ratio of equal partial size and average thickness is 0.5~50.
5. composition for oral cavity as described in any one of claims 1 to 4, which is characterized in that the composition for oral cavity is
The non-Formulation of (A) ingredient containing 0.1~30 mass %.
6. composition for oral cavity as claimed in claim 5, which is characterized in that the composition for oral cavity is dentifrice or gargles
Agent.
7. composition for oral cavity as described in any one of claims 1 to 4, which is characterized in that the composition for oral cavity is
The Formulation of (A) ingredient containing 0.1~95 mass %.
8. such as composition for oral cavity according to any one of claims 1 to 7, which is characterized in that the composition for oral cavity is also
Contain 0.1~10 mass % of (B) surfactant.
9. such as composition for oral cavity according to any one of claims 1 to 8, which is characterized in that the composition for oral cavity is used
In tooth whitening.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017-117531 | 2017-06-15 | ||
| JP2017117531A JP2019001747A (en) | 2017-06-15 | 2017-06-15 | Oral composition |
| PCT/JP2018/020506 WO2018230325A1 (en) | 2017-06-15 | 2018-05-29 | Composition for use in oral cavity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110198699A true CN110198699A (en) | 2019-09-03 |
Family
ID=64659271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880007910.9A Pending CN110198699A (en) | 2017-06-15 | 2018-05-29 | Composition for oral cavity |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2019001747A (en) |
| KR (1) | KR20200015449A (en) |
| CN (1) | CN110198699A (en) |
| WO (1) | WO2018230325A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022083996A1 (en) | 2020-10-22 | 2022-04-28 | Unilever Ip Holdings B.V. | An oral care composition for whitening benefits |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5467596A (en) * | 1977-11-09 | 1979-05-31 | Matsushita Electric Ind Co Ltd | Preparation of hexagonal plate zinc oxide crystal powder |
| JP2003183142A (en) * | 2001-12-19 | 2003-07-03 | Lion Corp | Process and composition for whitening tooth |
| US20090017303A1 (en) * | 2007-06-12 | 2009-01-15 | Fas Alliances, Inc. | Zinc oxide having enhanced photocatalytic activity |
| CN101394827A (en) * | 2006-03-22 | 2009-03-25 | 宝洁公司 | Oral zinc compositions |
| CN105960379A (en) * | 2014-02-07 | 2016-09-21 | 堺化学工业株式会社 | Hexagonal plate-like zinc oxide particles, production method therefor, cosmetic, filler, resin composition, infrared reflective material, and coating composition |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS483155Y1 (en) | 1970-10-08 | 1973-01-26 | ||
| JP3997371B2 (en) | 1999-01-28 | 2007-10-24 | ライオン株式会社 | Teeth whitening set |
| JP4548582B2 (en) | 2004-06-22 | 2010-09-22 | ライオン株式会社 | Teeth whitening set |
| JP4919009B2 (en) | 2006-06-23 | 2012-04-18 | ライオン株式会社 | Tooth makeup set |
-
2017
- 2017-06-15 JP JP2017117531A patent/JP2019001747A/en active Pending
-
2018
- 2018-05-29 WO PCT/JP2018/020506 patent/WO2018230325A1/en active Application Filing
- 2018-05-29 CN CN201880007910.9A patent/CN110198699A/en active Pending
- 2018-05-29 KR KR1020197026233A patent/KR20200015449A/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5467596A (en) * | 1977-11-09 | 1979-05-31 | Matsushita Electric Ind Co Ltd | Preparation of hexagonal plate zinc oxide crystal powder |
| JP2003183142A (en) * | 2001-12-19 | 2003-07-03 | Lion Corp | Process and composition for whitening tooth |
| CN101394827A (en) * | 2006-03-22 | 2009-03-25 | 宝洁公司 | Oral zinc compositions |
| US20090017303A1 (en) * | 2007-06-12 | 2009-01-15 | Fas Alliances, Inc. | Zinc oxide having enhanced photocatalytic activity |
| CN105960379A (en) * | 2014-02-07 | 2016-09-21 | 堺化学工业株式会社 | Hexagonal plate-like zinc oxide particles, production method therefor, cosmetic, filler, resin composition, infrared reflective material, and coating composition |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019001747A (en) | 2019-01-10 |
| WO2018230325A1 (en) | 2018-12-20 |
| KR20200015449A (en) | 2020-02-12 |
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