JP4919009B2 - Tooth makeup set - Google Patents

Description

  The present invention relates to a tooth cosmetic set using a coating composition and a film composition in combination, which gives a tooth gloss or any color tone by forming or coating a film on the surface of the tooth. Is applied to the interdental part, the gingival marginal part, the tooth tip part, etc. that cannot be covered with the film composition, and the coating composition or film composition is used. The present invention relates to a dental cosmetic set that can provide an excellent appearance without color unevenness that cannot be obtained when used alone, and that is durable and does not easily peel off from a tooth and has excellent gloss.

  Many coating compositions using a water-insoluble film-forming agent have been proposed for the purpose of temporarily changing the color tone of the teeth with a cosmetic sensation or preventing the coloring of teeth (Patent Documents 1 to 3). No. -82821, JP-A-6-256147, JP-A-9-1000021). However, even if the moisture on the surface of the teeth is sufficiently removed before application, it is difficult to apply evenly because it is wet again with saliva during application and the film is deposited unevenly. In addition, the act of “painting” itself is the cause of coating unevenness, and as long as it is a coating form, it was not possible to completely escape from the coating unevenness.

On the other hand, examples have been proposed in which a film composition is affixed to a tooth as a removal of colored stains on the tooth surface or as a decorative seal (Patent Documents 4 and 5: Japanese Patent Laid-Open Nos. 10-17448 and 2003-212742). Gazette), when the film composition is intended to cover the teeth and change the color of the teeth, if the entire lip side of the teeth cannot be covered cleanly, the contrast between the part where the film composition is applied and the part where the film composition is not applied Expanded and emphasized unnaturalness. In order to solve this problem, it is necessary to carefully cut the film composition in accordance with different tooth sizes. However, it takes a lot of time and labor, and there are problems in operability and simplicity.
In addition, the example which used coating composition and a film composition together is not reported.

JP-A-4-82821 JP-A-6-256147 Japanese Patent Laid-Open No. 9-1002015 Japanese Patent Laid-Open No. 10-17448 JP 2003-221742 A

  The present invention has been made in view of the above circumstances, and gives a gloss or any color tone to the teeth by forming or applying a film on the surface of the teeth, and there is no unevenness in appearance, and is simple and easy to operate. An object of the present invention is to provide a tooth cosmetic set which is excellent in durability and does not easily peel off from teeth.

The present inventors have made intensive studies to achieve the above object, a water-insoluble film-forming agent, a plasticizer 及 beauty white pigment containing film composition for tooth surfaces stuck formed as a film (B ), A water-insoluble film-forming agent, a lower alcohol having 2 to 4 carbon atoms and a white pigment, and a coating composition (A) for application to a tooth surface to which the film composition is not applied. A tooth cosmetic set consisting of two dosage forms: a film composition (B) applied to a tooth, and an interdental portion and a gingival margin that cannot be covered with the film composition (B) And by coating the tip of the tooth with the coating composition (A), the tooth surface that cannot be covered with the film composition can be coated by applying the coating composition, and a film is uniformly formed on the tooth surface. The tooth surface is coated without uneven color, which makes the teeth glossy and any The given, gloss is good, unevenness in appearance with little tone, moreover, the operability is excellent in convenience, readily without peeling off from the tooth, found that can whitening satisfactorily teeth, the present invention has been accomplished.

  In this case, the coating composition (A) preferably further contains at least one selected from hydroxypropylcellulose, hydroxypropylmethylcellulose and polyvinylpyrrolidone as a thickener. Further, the water-insoluble film forming agent is made of shellac, methyl methacrylate / ethyl acrylate / methacrylated trimethylammonium ethyl copolymer, or (meth) acrylic acid (alkyl ester or alkyl amide). And at least one selected from (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymers, and the plasticizer of the film composition (B) may be triethyl citrate and / or an average molecular weight of 400. ~ 2,000 polypropylene glycol is preferred. The white pigment is preferably titanium oxide.

Accordingly, the present invention is water-insoluble film-forming agent, and dosage form of the plasticizer, and a white pigment containing film composition for tooth surfaces stuck formed as a film (B), water-insoluble film-forming agent, carbon It comprises two dosage forms including a dosage form of a coating composition (A) for application to a tooth surface to which the film composition is not applied, which contains a lower alcohol of formula 2 to 4 and a white pigment. To provide a tooth makeup set.

  The tooth cosmetic set of the present invention consists of two dosage forms, a coating composition and a film composition, so that it takes time and labor to apply the film composition to the teeth and to cover with the film composition. By covering the part, gingival margin, tooth tip, etc. with the coating composition, excellent simplicity and operability, uniform appearance and excellent gloss, and durability that does not easily peel off the teeth It gives the teeth gloss, luster and good color tone and is excellent in the whitening effect of the teeth.

  Hereinafter, the present invention will be described in more detail. The tooth cosmetic set of the present invention includes a coating composition (A) comprising a water-insoluble film-forming agent, a lower alcohol having 2 to 4 carbon atoms, and a white pigment. , A water-insoluble film forming agent, a plasticizer, and a film composition (B) containing a white pigment.

  The film-forming agent used in the coating composition (A) is a water-insoluble film-forming agent. In this case, the solubility of the water-insoluble film-forming agent used in water is determined visually by the following method. did. That is, 0.1 g was added to 100 g of a 1 mmol / L calcium chloride aqueous solution (adjusted to pH 6.0 with sodium hydroxide), stirred at 37 ° C. for 16 hours, and further allowed to stand at 37 ° C. for 24 hours. The case was determined to be water insoluble.

  The water-insoluble film-forming agent used in the coating composition (A) is not particularly limited, but cellulose derivatives such as shellac, ethyl cellulose, carboxymethyl ethyl cellulose, vinyl acetate resin, chitin, chitosan, methyl methacrylate / butyl methacrylate / methacryl Aminoalkyl methacrylate copolymers such as dimethylaminoethyl acid copolymer, methyl methacrylate / ethyl acrylate / methacrylated trimethylammonium ethyl copolymer, methyl (meth) acrylate / methacrylic acid copolymer copolymer, methacrylic acid / acrylic Acid ester / tert-butyl acrylate copolymer, neutralized product of acrylic acid ester / methacrylic acid ester with 2-amino-2-methyl-1-propanol, octyl acrylate / acrylic acid ester Polymer, (meth) acrylic acid / ethyl acrylate / acrylic acid tert-butylamide copolymer or other (meth) acrylic acid (alkyl ester or alkylamide) copolymer, (methacryloyloxyethylcarboxybetaine) / Alkyl methacrylate) copolymer, polyvinyl acetal diethylaminoacetate, etc. Among them, shellac, methyl methacrylate / ethyl acrylate / methacrylated trimethylammonium ethyl copolymer, (meth) acrylic acid (alkyl ester or alkylamide) 2) or a copolymer of (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) is preferable, and in particular, shellac, methyl methacrylate / alkali value is 24 to 32 mg KOH / dry mass / Ethyl acrylic acid / methacrylate trimethylammonium chloride methacrylate copolymer are preferable.

  The shellac used in the present invention is a natural resin secreted by Larva spp., And according to “Science and Industry Vol. 51”, p356 to 361, the component is a condensate of hydroxycarboxylic acid by an ester or lactone bond It is considered to be. Examples thereof include dry transparent white racks and dry milky white racks manufactured by Nippon Shellac Kogyo Co., Ltd.

Moreover, as a methyl methacrylate / ethyl acrylate / methacrylated trimethylammonium ethyl copolymer, this product is dissolved in an isopropanol / acetone mixed solution (60/40 (w / w)) to obtain a 12.5% solution. Those prepared and measured with a Brookfield viscometer (UL adapter, rotation speed 30 rpm, 20 ° C., measurement time 2 minutes) have a viscosity of 1 to 15 mPa · s. For example, degussa. Examples include Eudragit RLPO and RSPO manufactured by the company.
Further, the methyl methacrylate / ethyl acrylate / methacrylated trimethylammonium ethyl copolymer preferably has an alkali value of 24 to 32 mg KOH / dry mass, for example, degussa. The Eudragit RLPO manufactured by the company is suitable. The alkali value was measured by titrating basic functional groups contained in 1 g of a dried sample with perchloric acid.

Two or more kinds of copolymers selected from (meth) acrylic acid (alkyl ester or alkylamide) are prepared by using a 20% by mass ethanol solution of a BL-type viscometer (No. 1 or 2 rotor, rotation speed 12 rpm, 20 ° C., Those having a viscosity of 10 to 2,500 mPa · s when measured at a measurement time of 2 minutes are preferred.
Furthermore, it is preferable that the alkyl chain length contained in the 2 or more types of copolymer chosen from (meth) acrylic acid (alkyl ester or alkylamide) is C1-C4 or C8.

  Examples of such two or more copolymers selected from (meth) acrylic acid (alkyl ester or alkylamide) include, for example, Eudragit S100, which is a methyl methacrylate / methacrylic acid copolymer, and methyl acrylate / methacrylic acid. Eudragit L100 which is a copolymer (manufactured by Degussa), RUBYMER 100P which is a methacrylic acid / ethyl acrylate / tert-butyl acrylate copolymer (manufactured by BASF), 2-amino of acrylic acid ester / methacrylic acid ester -2-Methyl-1-propanol neutralized product plus size L-53P (manufactured by Kyoyo Chemical Industry Co., Ltd.), acrylic acid octylamide / acrylic acid ester copolymer AMPHOMER V-42 (National Starch and Chemical l Co.), Ultrahold Strong (BASF) and the like is acrylic acid / ethyl acrylate / acrylic acid tert- butylamide copolymer.

(Methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer is a 30% by mass ethanol solution BL type viscometer (No. 1-3 suitable rotor, rotation speed 12 rpm, 20 ° C., measurement time 2 minutes) Those having a viscosity of 50 to 10,000 mPa · s as measured by the above are preferred.
Furthermore, the alkyl chain length contained in the (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer is preferably 1 to 4, 6, 8, 12, 13 or 18 carbon atoms.
Examples of such a (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer include Yuker Former 202, Yuker Former SM (manufactured by Mitsubishi Chemical Corporation), and the like.

  In the coating composition (A), one of the above water-insoluble film-forming agents can be used alone, or two or more of them can be mixed and used. 50% (mass percentage, the same applies hereinafter) is preferable, and more preferably 10 to 40%. If the blending amount is less than 10%, sufficient film strength cannot be obtained, the durability of the film is lowered, and the operability may be deteriorated. When it exceeds 50%, not only the drying property is lowered and the operability is deteriorated, but also the gloss is sometimes lowered.

  Examples of the lower alcohol having 2 to 4 carbon atoms used in the present invention include ethanol, isopropyl alcohol, butanol and the like, and ethanol is particularly preferable. The blending amount of the lower alcohol having 2 to 4 carbon atoms used in the coating composition (A) is preferably 15 to 88%, particularly preferably 34 to 86% of the entire coating composition.

  The white pigment used in the present invention is not particularly limited. For example, mica titanium, kaolin, talc, calcium carbonate, silicic acid anhydride, fish scale foil, zinc oxide, low-temperature fired zinc oxide, calcium oxide, titanium oxide, zirconium oxide, mica , Aluminum oxide, sericite, and composites thereof, among which titanium oxide is preferable.

As titanium oxide, titanium oxide having a particle diameter of a dendritic minor axis of 0.04 to 0.07 μm and a major axis of 0.2 to 0.3 μm is particularly preferable because of transparency. Such dendritic titanium oxide is commercially available under the trade names TTO-D-1 and TTO-D-2 (both manufactured by Ishihara Techno Co., Ltd.).
In addition, the said particle diameter expanded 100,000 times using an electron microscope (product made from Hitachi High-Technologies Corporation, S-3000N), and measured the length of the major axis and minor axis of 10 samples selected arbitrarily. The average value was calculated for each.

  The white pigment may be used alone or in combination of two or more. The blending amount of the white pigment in the coating composition (A) is preferably 1 to 10% of the entire coating composition, more preferably 1 ~ 8%. When the blending amount is less than 1%, sufficient color tone may not be imparted to the teeth even if it is overcoated. When the blending amount exceeds 10%, unnatural color tone and gloss reduction may result. There is.

  Furthermore, it is preferable to add a thickener to the coating composition (A) of the present invention in order to impart viscosity to improve operability and suppress coating unevenness. Although the kind in particular of a thickener is not restrict | limited, 1 type (s) or 2 or more types chosen from hydroxypropyl cellulose, hydroxypropyl methylcellulose, and polyvinylpyrrolidone are preferable.

  Hydroxypropylcellulose used as a thickener is not particularly limited, but the viscosity (20 ° C.) of a 2% by weight aqueous solution is a single cylindrical rotational viscometer (TVB-20L type manufactured by Tokimec Co., Ltd., rotor No. L, M2). Or, when M4 is used and measured at a rotational speed of 60 rpm and a measurement time of 4 minutes, it is preferably 6 to 4,000 mPa · s, for example, HPC-L (6 to 10 mPa · s) manufactured by Nippon Soda Co., Ltd. , HPC-M (150 to 400 mPa · s) and HPC-H (1,000 to 4,000 mPa · s).

Hydroxypropylmethylcellulose is not particularly limited, but it is 2 to 5,000 mm when the viscosity (20 ° C.) of a 2% by weight aqueous solution is measured according to the first method of viscosity measurement method of the Japanese Pharmacopoeia 13th revision, general test method. ² / s, particularly preferably ² to 1,200 mm ² / s, and the methoxyl group and hydroxypropoxyl group are quantified by the 14th revision of the Japanese Pharmacopoeia, Articles and Comments Part 2 The methoxyl group is preferably 27 to 30%, particularly 28 to 30%, and the hydroxypropoxyl group 4 to 12%, particularly 7 to 12%. Examples of such hydroxypropyl methylcellulose include TC-5R and Metrolose 65SH manufactured by Shin-Etsu Chemical Co., Ltd., and the viscosity is particularly 2-1200 mm ² / s, and the methoxyl group and the hydroxypropoxyl group are respectively TC-5R manufactured by Shin-Etsu Chemical Co., which is 28 to 30% and 7 to 12% is preferable.

  As polyvinylpyrrolidone, those having a K value of 12 to 90 are preferred, and those having a K value of 25 to 90 are more preferred. The K value was calculated by the method described in the Japanese Pharmacopoeia 14th Amendment, Articles and Comments Part 2. Examples of commercially available products corresponding to these include Kollidon 30 (K value 27 to 32.4) and Kollidon 90F (K value 81 to 97.2) manufactured by BASF.

  When a thickener is blended, the blending amount is preferably 0.1 to 5%, and particularly preferably 0.5 to 3% of the entire coating composition. When the blending amount exceeds 5%, not only the viscosity becomes too high, the operability is lowered and unevenness or gloss is lowered, but also the durability may be lowered.

A plasticizer can be added to the coating composition (A) as necessary. The type of plasticizer is not particularly limited, but water, triethyl citrate, polypropylene glycol having an average molecular weight of 400 to 2,000, and the like are preferable. The average molecular weight of polypropylene glycol was determined by measuring the hydroxyl value according to the hydroxyl value measurement method described in the Cosmetic Raw Material Standard (2nd edition comment), and calculating the average molecular weight. The calculation formula is as follows.
In the case of polypropylene glycol (diol type)
Average molecular weight = 56.11 × 2000 / hydroxyl value In the case of polypropylene glycol (triol type),
Average molecular weight = 56.11 × 3000 / hydroxyl value

  0-20% of the whole coating composition is preferable, and, as for the compounding quantity of the plasticizer to a coating composition (A), More preferably, it is 2-15%. When the blending amount exceeds 20%, not only the drying property is lowered and the operability is deteriorated, but also the film strength is lowered and it may be easily peeled off.

  For example, when a thickener is added, the coating composition (A) is first added to anhydrous ethanol or the like, stirred and dissolved in a sealed container, and then preliminarily dissolved in a lower alcohol. It can be prepared by adding a forming agent and dispersing uniformly, and finally adding a plasticizer dropwise if necessary, and adding and dispersing a white pigment. In addition, pH is adjusted using a pH adjuster as needed.

  The film composition (B) of the present invention is, for example, a solution in which a water-insoluble film-forming agent, a plasticizer, a white pigment, and a thickener as necessary are dispersed in a volatile solvent such as ethanol (hereinafter referred to as a solution) The film composition (B) is abbreviated as a precursor solution.) Is spread on a support such as a sheet coated with silicone or the like to remove the volatile solvent, and then the support is peeled off. In addition, as a volatile solvent, ethanol etc. can be used and the usage-amount is 50 to 80% in the precursor solution of a film composition (B).

In the present invention, the content (%) of each component in the film composition (B) is a value calculated by (Equation 1) shown below.

  The water-insoluble film forming agent used in the film composition (B) can be the same as the water-insoluble film forming agent used in the coating composition (A), and can be used in the coating composition (A). It may be the same as or different from the water-soluble film forming agent. The water solubility of the water-insoluble film forming agent used in the film composition (B) can also be determined in the same manner as the water-insoluble film forming agent used in the coating composition (A). .

  The content of the water-insoluble film-forming agent used in the film composition (B) is preferably 48 to 91%, more preferably 57 to 86% of the entire film composition. When the content is less than 48%, sufficient film strength cannot be obtained, and the operability may be reduced due to damage at the time of sticking, and when it exceeds 91%, the flexibility of the film is lowered and the operation is decreased. In addition to the worsening of the properties, there are cases where the adhesion to the teeth is lowered and peeling easily occurs.

The white pigment used in the film composition (B) can be the same as the white pigment used in the coating composition (A), and is the same as or different from the white pigment used in the coating composition (A). May be.
The content of the white pigment used in the film composition (B) is preferably 1 to 11%, more preferably 3 to 9% of the entire film composition. If the content is less than 1%, sufficient color tone may not be imparted to the teeth, and if it exceeds 11%, unnatural color tone and gloss reduction may occur.

  Furthermore, the ratio of the white pigment content (mass%) of the coating composition (A) / white pigment content (mass%) of the film composition (B) is 0.10 to 6.0, particularly preferably 0.00. It is preferable that it is 20-2.5. When the mass ratio is less than 0.10, the color tone of the film composition (B) is too dark and the contrast with the color tone of the coating composition (A) increases, and the entire surface of the teeth cannot be evenly arranged. Appearance may deteriorate. On the other hand, when the mass ratio exceeds 6.0, the color tone of the coating composition (A) may be too dark and the contrast with the color tone of the film composition (B) may increase, resulting in poor appearance.

  Examples of the plasticizer used for the film composition (B) of the present invention include glycerin, diglycerin, polyglycerin, butylene glycol, polypropylene glycol having an average molecular weight of 400 to 2,000, preferably 400 to 1,500, and quencher. Examples include triethyl acid, acetyl glycerin fatty acid ester, butyl phthalyl butyl glycolate, and the like. Polypropylene glycol having an average molecular weight of 400 to 2,000 and triethyl citrate are particularly preferable. In addition, the average molecular weight of polypropylene glycol measured the amount of hydroxyl groups (mol) according to the hydroxyl value measuring method described in the cosmetic raw material standard (the 2nd edition comment), and calculated the average molecular weight.

  The content of the plasticizer is preferably 8 to 35%, particularly preferably 10 to 30% of the entire film composition. If the plasticizer content is less than 8%, the adhesiveness to the teeth may be lowered and the operability and durability may be deteriorated. If it exceeds 35%, the adhesiveness to fingers and the flexibility of the film Not only is the property too high, the operability is lowered, but the film may be wrinkled and gloss may be lowered.

  A thickener can be added to the film composition (B) of the present invention as necessary. The type of the thickener is not particularly limited, but hydroxypropylcellulose, hydroxypropylmethylcellulose, and polyvinylpyrrolidone are preferable, and the same thickener used in the coating composition (A) can be used. In addition, it may be the same as or different from the thickener used in the coating composition (A).

  The content of the thickener in the film composition (B) is preferably from 0 to 6%, particularly preferably from 0.1 to 4%, based on the entire film composition. When content exceeds 6%, the adhesiveness to a tooth | gear may fall and it may become easy to peel.

10-500 micrometers is preferable and, as for the thickness of the film of a film composition (B), 30-200 micrometers is especially preferable. When the thickness is less than 10 μm, the film is too soft and the operability at the time of application is poor, and the gloss and appearance may be deteriorated due to breakage and wrinkles. When the thickness exceeds 500 μm, it is difficult to match the color tone of the coating composition (A) and the film composition (B) and the appearance is deteriorated, and the contact between the film composition (B) and the lips is not good. It may increase and become easy to peel off from a tooth. In addition, the film thickness of the film composition (B) is a value obtained by enlarging and measuring using a digital microscope (manufactured by Keyence Corporation, VH-8,000).

Further, the area of the film of the film composition (B) is preferably 3 to 60 mm ² , more preferably 5 to 50 mm ^2. It is desirable to affix to the surface. When the area is less than 3 mm ² , it is too small and the operability at the time of application is not good, and the good appearance of the film composition (B) may not be utilized. When the area exceeds 60 mm ² , it is necessary to apply so as not to protrude from the teeth, so that it takes a lot of time to apply, and the convenience may be reduced. In addition, the area of the film formed by the film composition (B) is obtained by using WinROOF Ver5 (manufactured by Mitani Corporation) from an image acquired with a digital microscope (manufactured by Keyence Corporation, VH-8,000). Measured value.

  In the coating composition (A) and the film composition (B) of the present invention, other components can be appropriately blended as necessary.

For example, for the purpose of emulsification, dispersion, etc., one type of surfactant such as an anionic surfactant, a nonionic surfactant, or a zwitterionic surfactant is used alone or in combination of two or more. be able to.
In this case, anionic surfactants include alkyl sulfates such as sodium lauryl sulfate, sodium N-acyl glutamate such as sodium N-lauroyl glutamate, sodium N-palmitoyl glutamate, sodium N-lauroyl sarcosine, and sodium N-myristoyl sarcosine. N-acyl sarcosine sodium, N-lauroylmethyl taurine sodium, N-methyl-N-acyl taurine sodium such as sodium N-myristoylmethyl taurine, N-methyl-N-acylalanine sodium, sodium laurylbenzenesulfonate, hydrogen Added coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, lauryl polyoxyethylene POE) sodium sulphate, sodium lauryl POE acetate, sodium lauryl POE phosphate, stearyl POE sodium phosphate and the like are used.

  Nonionic surfactants include glycerin fatty acid esters such as monoglyceryl stearate and decaglyceryl laurate, sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester, lactose fatty acid ester, maltitol fatty acid ester, lactitol fatty acid ester, etc. Sugar alcohol fatty acid esters, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, myristic acid mono- or diethanolamide Fatty acid ethanol amide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxy Propylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester or the like is used.

  Zwitterionic surfactants include alkyldimethylaminoacetic acid betaines such as lauryldimethylaminoacetic acid betaine, N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine, N-myristyldiaminoethylglycine, and N-alkyl-N-carboxyl. Methyl ammonium betaine, 2-alkyl-1-hydroxyethyl imidazoline betaine sodium and the like are used.

  The blending amount of the surfactant in the coating composition (A) and the content in the film composition (B) are 0.01 to 1%.

  Furthermore, in the present invention, as an active ingredient, enzymes such as dextranase, mutanase, lysozyme, amylase, protease, lytic enzyme, superoxide dismutase, water-soluble polyphosphate such as sodium pyrophosphate, sodium tripolyphosphate, sodium metaphosphate Salt, allantoin, dihydrocholestanol, glycyrrhizic acid, glycyrrhetinic acid, ε-aminocaproic acid, tranexamic acid, bisabolol, isopropylmethylphenol, sodium chloride, triclosan, chlorhexidine salts, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, ascorbic acid And herbal extracts such as salts thereof, tocopherols, hornons, psyllium, rosemary, clove, thyme, and the like. In addition, a compounding quantity can be made into an effective quantity in the range which does not prevent the effect of this invention.

  Each of the coating composition (A) and the film composition (B) of the present invention further includes a perfume such as anethole, carvone, peppermint oil, spearmint oil, benzoic acid or a sodium salt thereof, a preservative such as parabens, Pigment or colorant such as Red No. 3, Red No. 104, Yellow No. 4, Blue No. 1, Green No. 3, Bengala, sweeteners such as saccharin or its sodium salt, stevioside, glycyrrhizin, aspartame and the like can be blended.

  The pH of the coating composition (A) and the film composition (B) of the present invention is not particularly limited as long as it is in a range that does not cause safety problems in the oral cavity and the human body, and the pH of each composition is Although it may be the same or different, the pH of the aqueous phase when diluted 10-fold with purified water is preferably 5.0 to 10.0, more preferably 5.5 to 9.0. . When the pH is less than 5.0, there is a concern of decalcification depending on the application time, and when the pH exceeds 10.0, the taste may be deteriorated. Examples of pH adjusters include acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, sodium phosphate, phosphorus Sodium oxyhydrogen can be blended.

  The tooth cosmetic set of the present invention, for example, after removing saliva on the surface of the tooth if necessary, affixing the film composition (B) to the surface of the tooth, and further cannot be covered with the film composition (B) The coating composition (A) can be coated and coated on the surface of the teeth, and in this case, the entire tooth is coated with the coating composition (A) from above the film composition (B) (on the tooth surface). The coating composition (A) may be applied over the pasted film).

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%.

[Examples 1 to 28, Comparative Examples 1 to 8]
A coating composition and a film composition having the compositions shown in Tables 1 to 5 were prepared by the following methods, and each was evaluated as the tooth cosmetic set by the following method. The results are shown in Tables 1-5.

Preparation Method of Coating Composition (A) When a thickener was added, it was first added to absolute ethanol and dissolved by stirring in a closed container. Subsequently, a water-insoluble film forming agent previously dissolved in ethanol was added and dispersed uniformly. Finally, a plasticizer was added dropwise as necessary, and a pH adjusting agent and a pigment were added and dispersed to obtain a coating composition (A). In addition, pH measured the pH of the water phase in 25 degreeC when diluting 10 times with purified water with the pH meter (Toa DKK Corporation make, HM-26S).

Method for preparing film composition (B) and calculating method for content of each component (1) Method for preparing film composition (B) Add water-insoluble film-forming agent to ethanol, and stir and dissolve in a sealed container Thereafter, a plasticizer and a white pigment were added and dispersed (partially collected at this stage and measured for pH in the same manner as the coating composition (A)). Subsequently, the mass (W0) of each sheet was measured at the same time that the surface was spread on a polyethylene terephthalate sheet (mass Wf) coated with silicon. After leaving still in a 40 degreeC thermostat for 24 hours, the mass (W1) was again measured with the sheet | seat. The calculation formula for the content of each component is as follows. Finally, it peeled from the polyethylene terephthalate sheet and obtained the film.

滴定前重量：Ｗ２
サンプル滴定量：Ｖ１
ブランク滴定量：Ｖ０ (2) Alkali value determination method for methyl methacrylate / ethyl acrylate / methacrylated trimethylammonium ethyl copolymer First, 1 g of a sample was accurately weighed in a glass petri dish and placed in a thermostat at 80 ° C. for 5 hours. After standing, it was accurately weighed again to determine the dry mass DW.
Dry mass DW = W1 / W0
Weight before drying: W0
Weight after drying: W1
Separately, 2 g of sample was accurately weighed (W2), dissolved in 96 mL of glacial acetic acid and 4 mL of purified water, 5 mL of a glacial acetic acid solution of 5% mercury (II) acetate was added, and titrated with a 0.1 mol / L perchloric acid aqueous solution. . Similarly, titration was performed using a blank.

Weight before titration: W2
Sample titration: V1
Blank titration: V0

Evaluation Method of Convenience / Operability, Appearance, Gloss, Durability Sensory evaluation was performed by the following method using 10 subjects. First, the saliva is removed by lightly pressing the lip surfaces of the left and right teeth 1 to 3 of the upper jaw with a tissue, and the film prepared from the film composition (B) by the above method is cut into a predetermined size into teeth. Affixed. Next, the coating composition (A) was applied to a portion that could not be covered with the film using a flat brush. The film prepared from the film composition (B) was attached, and “simpleness / operability” was evaluated by the time until the application of the coating composition (A) was completed.
Furthermore, the test subject stood upright with his mouth widened and his teeth extended, and evaluated the “appearance” at a distance at which the evaluator gradually approached the test subject and began to feel discomfort such as color unevenness.
Further, the gloss was evaluated from a location 50 cm away.
Furthermore, the intraoral area immediately after the treatment was photographed with a size of 1 / 1.2 times. After 3 hours with the meal prohibited, the photograph was taken again, and the durability of the film prepared with the coating composition (A) and the film composition (B) was evaluated as “durability” compared to immediately after the treatment. did.
The criteria for each evaluation item are as follows.

Evaluation criteria for convenience and operability 4 points: less than 3 minutes 3 points: 3 minutes to less than 4.5 minutes 2 points: 4.5 minutes to less than 6 minutes 1 point: 6 minutes or more Appearance evaluation criteria 4 points: 50 cm There is no discomfort when approaching less than a distance.
3 points: Almost no discomfort is felt even at a distance of 50 cm or more and less than 1 m.
2 points: Feeling uncomfortable when approaching a distance of 1m or more and less than 2m.
1 point: Feeling uncomfortable even when viewed from a distance of 2 m or more.
Evaluation criteria for gloss: 4 points: There is gloss exceeding the original teeth.
3 points: Gloss equivalent to original teeth.
2 points: The gloss is slightly inferior to the original teeth.
1 point: There is almost no gloss.
Durability evaluation criteria 4 points: No peeling at all.
3 points: Slightly exfoliates only at the tip of the tooth, but at a level where there is no problem.
2 points: Not only the tip of the tooth but also at least one tooth is peeled less than 1/4.
1 point: At least one or more teeth are peeled by 1/4 or more.

For each evaluation item, the average score of the subjects was calculated, and the final evaluation was performed according to the following criteria.
Average score of subjects for each evaluation item ◎: 3.5 points or more ○: 2.6 points or more and less than 3.5 points △: 1.5 points or more and less than 2.6 points ×: Less than 1.5 points

Overall evaluation A: All evaluation items are A.
○: No x or Δ in all evaluation items, 0 to 3 in ◎.
Δ: There is no cross in all evaluation items, and there is one or more Δ in any evaluation item.
X: There is x in any evaluation item.

In the table, the numerical value of each component of the film composition (B) in each example is the blending amount in the precursor solution of the film composition (B). The numerical value in () is the content [calculated by (Equation 1)] of each component in the film composition (B) (hereinafter the same).

Water-insoluble film-forming agent Methyl methacrylate / ethyl acrylate / methacrylated trimethylammonium ethyl copolymer A; degussa. Manufactured by Eudragit RLPO, alkali value 28.0, viscosity 5 mPa · s
Methyl methacrylate / ethyl acrylate / methacrylated trimethylammonium ethyl copolymer B; degussa. Manufactured by Eudragit RSPO, alkali value 14.5, viscosity 4 mPa · s
Shellac: Nippon Shellac Kogyo Co., Ltd., dry transparent white rack lower alcohol ethanol; Gansu Chemical Industry Co., Ltd., anhydrous ethanol Isopropanol; Shin Nippon Petrochemical Co., Ltd., Isopropyl alcohol white pigment Titanium oxide-1; Ishihara Techno Co., Ltd., TTO-D-1, dendritic, short axis 0.05 μm, long axis 0.25 μm
Titanium oxide-2; manufactured by Ishihara Sangyo Co., Ltd., CR-50, spherical, average particle size 250 μm
Thickener Polyvinylpyrrolidone; PVP K90, manufactured by BASF Hydroxypropyl cellulose; Nippon Soda Co., Ltd., HPC-H, viscosity 2500 mPa · s
Hydroxypropyl methylcellulose; manufactured by Shin-Etsu Chemical Co., Ltd., TC-5R, viscosity 6.1 mm ² / s
Plasticizer Triethyl citrate; Pfizer Pharmaceutical Co., Ltd., Citroflex 2
Polypropylene glycol 400; manufactured by NOF Corporation, Uniol D-400, average molecular weight 400
Polypropylene glycol 700; manufactured by NOF Corporation, Uniol D-700, average molecular weight 700
Polypropylene glycol 2000; manufactured by NOF Corporation, Uniol D-2000, average molecular weight 2000
Other (water-soluble polymer)
Ethyl acrylate / methacrylic acid copolymer; degussa. Manufactured by Eudragit L100-55

  From the results of Examples 1 to 28 and Comparative Examples 1 to 8, the tooth cosmetic set of the present invention is excellent in all of the above four evaluation items (simpleness / operability, appearance, gloss, durability). confirmed.

Example 29
A tooth cosmetic set having the following composition was prepared and evaluated in the same manner as in Examples 1 to 28 described above. As a result, “simpleness / operability”, “appearance”, “gloss”, and “durability” were all “good”.
<Tooth makeup set 1>
○ Coating composition Methyl methacrylate / methacrylic acid copolymer 20%
(Degussa, manufactured by Eudragit S100, viscosity 930 mPa · s)
Ethanol (Gansu Chemical Industry Co., Ltd., absolute ethanol) 59.98%
Titanium oxide 8%
(Ishihara Techno Co., Ltd., TTO-51 (A), spherical, particle size 20 μm)
Polyvinylpyrrolidone (manufactured by BASF, PVP K30) 2%
Polyethylene glycol 400 10%
(Lion Corporation, PEG # 400K)
Potassium hydroxide 0.02%
Total 100.0%
(PH 7.5)

○ Film composition (): Mass% after drying calculated by (Equation 1)
(Methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer (Mitsubishi Chemical Corporation, Yuka Former 202, ethanol solution containing 30% active ingredient, viscosity 100 mPa · s) 93% (79.9%)
Polypropylene glycol 400 4% (11.5%)
(Nippon Yushi Co., Ltd., Uniol D-400, average molecular weight 400)
Zirconium oxide (N-PC, manufactured by Nippon Electric Works Co., Ltd.) 3% (8.6%)
Total 100.0%
(PH 8.2)
The film was spread on a polyethylene terephthalate film coated with silicone and dried at 40 ° C. for 24 hours to prepare a film composition having a thickness of 200 μm and an area of 35 mm ² .
The pigment content of the coating composition / the pigment content of the film composition is 0.93.

Example 30
A tooth cosmetic set having the following composition was prepared and evaluated in the same manner as in the previous examples. As a result, “simpleness / operability”, “appearance”, “gloss”, and “durability” were all “good”.
<Tooth makeup set 2>
○ Coating composition shellac (Nihon Shellac Industry Co., Ltd., dry transparent white rack) 35%
Ethylcellulose (Dow Chemical Co., Etocel 45P) 1%
Ethanol (manufactured by Gansu Chemical Industry Co., Ltd., absolute ethanol) 57.98%
Zinc oxide (manufactured by Sakai Chemical Industry Co., Ltd., NANOFINE-50, spherical) 5%
Hydroxypropyl cellulose 1%
(Nippon Soda Co., Ltd., HPC-L, viscosity 8.6 mPa · s)
Sodium hydroxide 0.02%
Total 100.0%
(PH 7.5)

○ Film composition (): Mass% after drying calculated by (Equation 1)
Acrylic acid / ethyl acrylate / acrylic acid tert-butylamide copolymer (manufactured by BASF, Ultrahold Strong, ethanol solution containing 40% active ingredient, viscosity 50 mPa · s) 92.98% (84.2%)
Triethyl citrate 5% (11.3%)
(Pfizer Pharmaceutical Co., Ltd., Citroflex 2)
Spherical silica coated with titanium oxide and silica in turn 2% (4.5%)
(Catalyst Chemical Industries, Ltd., ACS-152010)
Sodium citrate 0.02%
Total 100.0%
(PH 7.5)
The film was spread on a polyethylene terephthalate film coated with silicone and dried at 40 ° C. for 24 hours to prepare a film composition having a thickness of 200 μm and an area of 35 mm ² .
The pigment content of the coating composition / the pigment content of the film composition is 1.11.

Example 31
A tooth cosmetic set having the following composition was prepared and evaluated in the same manner as in the previous examples. As a result, “simpleness / operability”, “appearance”, “gloss”, and “durability” were all “good”.
<Tooth makeup set 3>
○ Coating composition Methyl acrylate / methacrylic acid copolymer 20%
(Degussa, manufactured by Eudragit L100, viscosity 272 mPa · s)
Ethanol (manufactured by Gansu Chemical Industry Co., Ltd., absolute ethanol) 66.99%
Purified water 10%
Mica titanium mica composite (Merck, EXTENDER W) 1%
Hydroxypropyl methylcellulose 2%
(Manufactured by Shin-Etsu Chemical Co., Ltd., Metrose 60SH, viscosity 50 mPa · s)
Sodium acetate 0.01%
Total 100.0%
(PH 5.8)

○ Film composition (): Mass% after drying calculated by (Equation 1)
Methacrylic acid / ethyl acrylate / tert-butyl acrylate copolymer (BASF Rubimer 100P, viscosity 50 mPa · s) 20% (78.4%)
Triethyl citrate (Pfizer Pharmaceutical Co., Ltd., Citroflex 2) 5% (19.6%)
Kaolin (manufactured by Tsuchiya Kaolin, Kaolin ASP) 0.5%
(2.0%)
Ethanol (Gansu Chemical Industry Co., Ltd., absolute ethanol) 74.48%
Sodium carbonate 0.02%
Total 100.0%
(PH 7.5)
The film was spread on a polyethylene terephthalate film coated with silicone and dried at 40 ° C. for 24 hours to prepare a film composition having a thickness of 200 μm and an area of 35 mm ² .
The pigment content of the coating composition / the pigment content of the film composition is 0.50.

[Example 32]
A tooth cosmetic set having the following composition was prepared and evaluated in the same manner as in the previous examples. As a result, “simpleness / operability”, “appearance”, “gloss”, and “durability” were all “good”.
<Tooth makeup set>
○ Coating composition Neutralized product of acrylic acid ester / methacrylic acid ester with 2-amino 2-methyl-1-propanol (manufactured by Kyoyo Chemical Industry Co., Ltd., plus size L53P, ethanol solution containing 50% active ingredient, viscosity 60 mPa・ S) 50%
Ethanol (Gansu Chemical Industry Co., Ltd., absolute ethanol) 32%
Silica-coated mica 3%
(Catalyst Chemical Industry Co., Ltd., velvet veil H type)
Titanium oxide 3%
(Ishihara Techno Co., Ltd., TTO-D-1, dendritic, short axis 0.05 μm, long axis 0.25 μm)
Polyvinylpyrrolidone (manufactured by BASF, PVP K30) 2%
Purified water 10%
Total 100.0%
(PH 7.2)

○ Film composition (): Mass% after drying calculated by (Equation 1)
Acrylic acid octylamide / acrylic acid ester copolymer 20% (74.1%)
(Manufactured by National Starch and Chemical, AMPHOMER
V-42, viscosity 100 mPa · s)
Triethyl citrate (Pfizer Pharmaceutical, Citroflex 2) 5% (18.5%)
Titanium oxide / silica coated sericite 1% (3.7%)
(Catalyst Chemical Industries, Ltd., SOFT VISION 05855Z)
Titanium oxide 1% (3.7%)
(Ishihara Techno Co., Ltd., TTO-D-1, dendritic, short axis 0.05 μm, long axis 0.25 μm)
Ethanol (manufactured by Gansu Chemical Industry Co., Ltd., absolute ethanol) 73%
Total 100.0%
(PH 6.2)
The film was spread on a polyethylene terephthalate film coated with silicone and dried at 40 ° C. for 24 hours to prepare a film composition having a thickness of 30 μm and an area of 35 mm ² .
The pigment content of the coating composition / the pigment content of the film composition is 0.81.

Example 33
A tooth cosmetic set having the following composition was prepared and evaluated in the same manner as in the previous examples. As a result, “simpleness / operability”, “appearance”, “gloss”, and “durability” were all “good”.
<Tooth makeup set>
○ Coating composition Ethyl cellulose (Dow Chemical Co., Etocel 45P) 4%
Ethanol (manufactured by Gansu Chemical Industry Co., Ltd., absolute ethanol) 92.5%
Heavy calcium carbonate (Shiraishi Kogyo Co., Ltd., White Inn P-70) 3%
Polyvinylpyrrolidone (manufactured by BASF, PVP K30) 0.5%
Total 100.0%
(PH 6.2)

○ Film composition (): Mass% after drying calculated by (Equation 1)
Polyvinyl acetal diethylaminoacetate 20% (78.4%)
(Daiichi Sankyo Co., Ltd., AEA Sankyo)
Triethyl citrate (Pfizer Pharmaceutical Co., Ltd., Citroflex 2) 5% (19.6%)
Fish scale foil (Kakuhachi fish scale foil, pearl essence) 0.5%
(2.0%)
Ethanol (manufactured by Gansu Chemical Industry Co., Ltd., absolute ethanol) 74.5%
Total 100.0%
(PH 8.8)
The film was spread on a polyethylene terephthalate film coated with silicone and dried at 40 ° C. for 24 hours to prepare a film composition having a thickness of 30 μm and an area of 35 mm ² .
The pigment content of the coating composition / the pigment content of the film composition is 1.50.

Claims (9)

Water-insoluble film-forming agent, plasticizers and film compositions for tooth surfaces stuck formed as to contain a white pigment film and the dosage form of (B), water-insoluble film-forming agent, lower 2 to 4 carbon atoms A dental cosmetic set comprising two dosage forms including a dosage form of an application composition (A) for application to a tooth surface containing an alcohol and a white pigment and not coated with the film composition . The tooth cosmetic set according to claim 1, wherein (white pigment content of coating composition (A)) / (white pigment content of film composition (B)) is 0.10 to 6.0 as a mass ratio. The water-insoluble film-forming agent is shellac, methyl methacrylate / ethyl acrylate / methacrylated trimethylammonium ethyl copolymer, two or more copolymers of (meth) acrylic acid (alkyl ester or alkyl amide), and (methacryloyloxyethyl carboxymethyl betaine / alkyl methacrylate) copolymer from it is Ru least one selected claim 1 or 2 teeth cosmetic set according. The water-insoluble film-forming agent is a shellac and / or methyl methacrylate / ethyl acrylate / methacrylic acid trimethylammonium ethyl copolymer having an alkali value of 24-32 mg KOH / dry mass. Teeth makeup set. The tooth cosmetic set according to any one of claims 1 to 4, wherein the plasticizer contained in the film composition (B) is triethyl citrate and / or polypropylene glycol having an average molecular weight of 400 to 2,000. The tooth cosmetic set according to any one of claims 1 to 5 , wherein the white pigment is titanium oxide. The tooth cosmetic set according to any one of claims 1 to 6, wherein the film of the film composition (B) has a thickness of 10 to 500 µm. The film area of the film composition (B) is 3 to 60 mm. ² The tooth cosmetic set according to any one of claims 1 to 7. The tooth cosmetic set according to any one of claims 1 to 8, wherein the coating composition (A) further contains at least one selected from hydroxypropylcellulose, hydroxypropylmethylcellulose and polyvinylpyrrolidone as a thickener.