JP3468508B2 - Tooth coloring ink and storage method - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an ink for coloring teeth and a method for storing the teeth, and more specifically, by applying to the surface of the tooth in the oral cavity, the surface of the tooth is drawn and printed with a chromatic color. The present invention relates to a tooth coloring ink that can be used and a storage method.

[0002]

2. Description of the Related Art By applying to the teeth of humans or animals,
Coloring inks used for drawing colored images on the surface of teeth, marking and marking, that is, edible inks for tooth application and art inks for tooth printing are generally used in the oral cavity. To be done. Therefore, it is harmless to the hygiene and is preferably composed of materials used for pharmaceuticals, quasi-drugs, cosmetics, etc., does not dissolve or fall off by saliva, and rubs the lip mucous membrane, tongue, etc. It is required to meet the requirements such as being able to withstand even various color tones.

Conventionally, as a tooth coating composition to be applied to the tooth surface, a coating solution for cosmetics of teeth, etc., for example, a cyanoacrylate is added to a vinyl resin coating composition, which is then added with a ketone or acetic acid. One dissolved in an organic solvent such as an ester type, one dissolved in a resin component such as a vinyl acetate resin and an acrylic ester copolymer resin in ethanol (JP-A-5-58844), N-methacryloylethyl N, N- A coating solution prepared by dissolving a dimethylammonium / α-N-methylcarboxybetaine / butyl methacrylate copolymer in ethanol (JP-A-9-100215).
Such as a specific acrylic acid / methacrylic acid ester-based copolymer dissolved in ethanol to form a coating solution (Japanese Patent Laid-Open No. 9-151123), a synthetic resin component in an organic solvent such as an ethanol solution, etc. Many dissolved products have been proposed and used.

However, it cannot be said that many of the synthetic resin components used in the above-mentioned composition and coating solution are harmless in terms of hygiene, and similarly, except that the solvent is also ethanol, there is a similar problem in terms of hygiene. is there. Therefore, it is preferable that the edible ink for tooth application or the art ink for tooth printing used in the human oral cavity is composed of a sanitary harmless natural material used for medicines, quasi-drugs, cosmetics and the like. .

As a suitable base material made of a natural material which meets the above requirements, shellac-ethanol solution can be mentioned. Shellac is a purified product of the secretions of the scale insect, Lac scale. It is a resinous substance that is insoluble in oil and soluble in ethanol and has been used for a long time as foods, cosmetics, pharmaceutical preparations (enteric coating, moisture-proof sealant coating) and the like. A solution of this shellac in ethanol is a shellac-ethanol solution.

When the shellac-ethanol solution is applied to the tooth surface, ethanol is immediately evaporated and a shellac resin film is formed on the tooth surface. The curing time of this resin film and the thickness of the cured film can be arbitrarily adjusted within a certain range by adjusting the concentration of the shellac-ethanol solution and the coating amount.

[0007]

However, in the above-mentioned edible ink for tooth coating or art ink for tooth printing which uses a shellac / ethanol solution as a base material, the color of the ink is a color other than white or black, that is, In the case of chromatic colors such as red, yellow, and blue, there is a problem that it is difficult to form a colored film having a clear color with a predetermined darkness. That is, even if various pigments are added to the edible ink for tooth coating based on a shellac-ethanol solution to add a color tone, the viscosity of the shellac-ethanol solution causes the pigment to be uniformly dissolved or dispersed. I couldn't.

As a countermeasure against this problem, a method of dissolving the pigment in ethanol and then dissolving the shellac has been adopted. However, the saturated solubility in ethanol differs depending on the type of pigment. Therefore, even if shellac was dissolved in a saturated ethanol solution of a pigment having a low saturated solubility in ethanol, it was not possible to obtain a tooth coloring ink capable of forming a film having a sufficient dark color. .

The tooth coloring ink is applied to the surface of the tooth which has almost no dye absorbing ability like the surface of the tooth, and the shellac resin itself used as the base material is substantially transparent. Furthermore, the film thickness formed is very thin. Therefore, even if an ink in which a pigment is dissolved to a saturated solubility is used to print or draw on the tooth surface, depending on the type of pigment, only a tint density that is indistinguishable from even imparting a color tone can be obtained. In some cases.

Therefore, the present invention has been made to solve the above problems in the conventional tooth coloring ink based on a shellac / ethanol solution, and has a clear and sufficient density on the tooth surface. It is an object of the present invention to provide an ink for coloring teeth and a storage method capable of realizing the above colors.

Further, another object of the present invention is to impart an antibacterial property to the above-mentioned tooth coloring ink and to contribute to the suppression of the growth of dental caries, periodontal disease bacteria and the like in the oral cavity. To provide ink.

[0012]

The ink for coloring teeth in the oral cavity according to the present invention comprises 1% by weight or more and 30% by weight or less of propylene glycol, 0.01% by weight or more and 10% by weight or less of glycerin fatty acid ester, and shellac 10. 40 parts by weight or more of titanium oxide powder in 100 parts by weight of a shellac-ethanol solution containing 50% by weight or more and 50% by weight or less
It is characterized in that it is composed of a suspension in which parts by mass or less and 0.1 parts by mass or more and 20 parts by mass or less of a colorant are uniformly dispersed.
By dispersing the titanium oxide powder and the colorant in the shellac / ethanol solution, the titanium oxide particles are present in a uniformly dispersed state so as to surround the colorant (pigment) particles. This causes a slow gelation phenomenon that extremely slows the gelation rate of the shellac-ethanol solution. Also, in the shellac resin film formed after the ethanol content volatilizes from the shellac-ethanol solution,
Since titanium oxide and the colorant (pigment) are scattered, a clear color tone can be given to the film.

The titanium oxide powder acts as a white pigment by itself, and diffusely reflects incident light in the shellac resin coating. The diffusely reflected light strikes the pigment particles adsorbed on the titanium oxide particles or the pigment particles existing between the titanium oxide particles, together with the direct incident light, and causes the white background to produce a distinct and vivid color.

In order for the shellac resin film to develop a clear color, the compounding ratio of titanium oxide, colorant (pigment), shellac resin and ethanol is within the range specified in the present invention, and the suspension is used. It is important that the titanium oxide particles and the pigment particles are kept in a stable and uniform dispersion state (suspension liquid state having a predetermined viscosity).

Further, according to the present invention, as one preferred embodiment of the above-mentioned tooth coloring ink, pigments excited by aluminum in the colorant, particularly food red No. 3, food yellow No. 4 and food blue No. 1 are used. Provided is an ink for coloring teeth in the oral cavity, which is characterized by using an aluminum-excited pigment which is at least one kind of food coloring selected.

Further, according to the present invention, there is provided an ink for coloring teeth in the oral cavity, characterized in that the titanium oxide powder has an average particle diameter of 10 μm or less. In order to keep the titanium oxide particles and the pigment particles in a stable and uniform dispersion state (suspension liquid state having a predetermined viscosity) in the suspension, the titanium oxide powder used in the present invention has an average particle diameter. It is preferable to use those having a thickness of 10 μm or less.

Further, according to the present invention, an antibacterial agent, in particular, at least one selected from pionine, hinokitiol, horseradish extract, chitosan, catechin, propolis and benzalkonium chloride is added and blended. An ink for coloring teeth in the oral cavity is provided. By adding an antibacterial agent to the tooth coloring ink, it is possible to exert an effect of suppressing the growth of dental caries, periodontal bacteria, etc. in the oral cavity.

Further, according to the present invention, there is provided an ink for coloring teeth in the oral cavity, characterized in that at least one selected from the antibodies of dental caries and the antibodies of periodontal disease are added and blended. Similar to the above-mentioned antibacterial agent, the tooth coloring ink can be provided with an effect of suppressing the growth of dental caries, periodontal bacteria, etc. in the oral cavity.

Further, according to the present invention, a storage method of the tooth coloring ink, characterized in that the storage temperature is 10 ° C. or lower, and the pH is maintained weakly alkaline, particularly, There is provided a method for storing the tooth coloring ink, wherein at least one selected from calcium carbonate, barium phosphate and egg calcium is blended as a pH adjuster. Further, there is provided a method for storing the tooth coloring ink, which is stored in a soda glass container. Prevention of gelation of the suspension,
From the viewpoint of maintaining a stable dispersion state, the suspension has a viscosity of 10
It is preferable that the pH is maintained weakly alkaline at a temperature of not higher than 0 ° C.

[0020]

BEST MODE FOR CARRYING OUT THE INVENTION The tooth coloring ink according to the present invention will be described in more detail below. The tooth coloring ink according to the present invention has a predetermined amount of titanium oxide powder and a predetermined amount in a shellac-ethanol solution prepared by dissolving shellac resin in ethanol containing a dispersibility improving agent consisting of propylene glycol and glycerin fatty acid ester. The colorant and the suspension are uniformly dispersed.

In the present invention, shellac, which is a resin component of the shellac-ethanol solution used as a base material, is a purified animal secretion product of the scale insect, Larva scale, which lives in India and Southeast Asia. . Its composition is a resin component 65 to 80% which is a lactide with allolitic acid, cerolic acid or the like, a wax component 4 to 8% which is an ester of ceryl alcohol or myricyl alcohol with myricin acid or cerotic acid, a protein, a saccharide. , Soluble salts and water. Its nature is
It is insoluble in oil, soluble in ethanol, and transparent in light yellow color. Further, as its application, it has been used for a long time as food, cosmetics, pharmaceutical preparations (enteric coating, moisture-proof sealant coating) and the like. Commercial products, depending on their purification grade,
It is classified into crude shellac, decolorized shellac, and pharmacopoeial shellac. In the present invention, any purification grade of shellac can be used, but the use of pharmacopoeia shellac is preferred.

In the present invention, the shellac-ethanol solution used as the base material is prepared by adding the above shellac resin and propylene glycol or glycerin fatty acid ester as a dispersibility improving agent to anhydrous alcohol (ethanol concentration 99.5% by volume or more). It contains 1% by mass or more and 30% by mass or less of propylene glycol, 0.01% by mass or more and 10% by mass or less of glycerin fatty acid ester, and 10% by mass or more and 50% by mass or less of shellac.

If the content of the shellac resin in the shellac-ethanol solution is less than 10% by mass, the effect of improving the fixability of the solution cannot be obtained, and 50% by mass is obtained.
When it exceeds, the viscosity becomes too high when it is made into a suspension, and the coatability is impaired. In particular, when the content is 15% by mass or more and 40% by mass or less, it is suitable from the viewpoints of applicability, stickiness, dryness on the tooth surface, film thickness after drying, and the like.

Propylene glycol and glycerin fatty acid ester act not only as a dispersibility improving agent for titanium oxide powder and a colorant but also as a plasticizer for shellac resin. Further, it contributes to the improvement of the stickiness, durability and flexibility of the formed shellac film. In addition, the content ratio of these is 1% by mass of propylene glycol.
30 mass% or less, glycerin fatty acid ester 0.0
It is preferably 1% by mass or more and 10% by mass or less in order to ensure stable and uniform dispersibility of the titanium oxide powder and the colorant in the liquid.

As described above, the tooth coloring ink according to the present invention comprises a suspension in which a predetermined amount of titanium oxide powder and a predetermined amount of colorant are uniformly dispersed in the shellac / ethanol solution. Become.

The titanium oxide powder used in the present invention is present in a shellac-ethanol solution in a uniformly dispersed state so as to surround the colorant particles added and added. Therefore, the gelation rate of the shellac-ethanol solution is delayed, and an effect of causing a delayed gelation phenomenon is exhibited. Furthermore, when the tooth coloring ink according to the present invention is applied, the incident light into the formed shellac resin film is diffusely reflected to realize a white base color. At the same time, a part of the diffusely reflected light strikes the pigment particles adsorbed on the titanium oxide particles or the pigment particles existing between the titanium oxide particles, thereby exhibiting an effect of vividly and vividly coloring from a white background.

Therefore, in order to effectively bring out the above-mentioned effects, the titanium oxide powder used in the present invention has a slow sedimentation rate in the shellac-ethanol solution and is uniformly dispersed in the solution. It is preferable that the particles are fine particles that can exist stably and continuously. From this point of view, the average particle size of the titanium oxide powder is 10 μm.
It is preferable to use m or less, especially 10 nm or more and 500 nm or less.

In the present invention, the content of the titanium oxide powder is 1 part by mass or more and 40 parts by mass or less, preferably 15 parts by mass or more and 35 parts by mass or less, based on 100 parts by mass of the shellac-ethanol solution. is there. The blending amount is
If the amount is less than 1 part by mass, the above effect cannot be sufficiently obtained. On the other hand, if the amount is more than 40 parts by mass, the flexibility of the formed film is lost and the adhesive strength is lowered, so that the film is easily separated.

In the tooth coloring ink according to the present invention,
The pigment used as a colorant is stable in an ethanol solvent and a shellac-ethanol solution, and can be used by dispersing or dissolving in the solution. Furthermore, as long as it is harmless in hygiene, does not dissolve and flow out by saliva, does not discolor in the oral cavity, and can withstand rubbing of the lip mucosa, tongue, etc., it can be used without particular limitation. it can.

Suitable colorants in the present invention include aluminum-excited pigments of dye dyes. Among them, food red No. 2 (Amaranth), food red No. 102 (new fuchsin), food red No. 3 (erythrosine), food red No. 105 (rose bengal), food red No. 106 (acid red), which are food dyes. Food yellow 4 (Tartrazine), food yellow 5 (Sansenoto Yellow FCF), food green 3 (Fast Green FCF) food blue 1 (Brilliant Blue FCF) food blue 2 (indigo carmine), etc. The lake pigment obtained by excitation is mentioned as a more suitable colorant. Among these, particularly, food red No. 3, food yellow No. 4, and food blue No. 1 aluminum-excited pigments are preferable.

The blending amount of the colorant is the shellac.
It is 0.1 part by mass or more and 20 parts by mass or less with respect to 100 parts by mass of the ethanol solution. That is, in the present invention, the pigment is present in the shellac-ethanol solution in a state of being surrounded by titanium oxide particles and dispersed,
Unlike the case of dissolving in ethanol, the concentration is not limited by the saturation solubility, and it can be blended at a higher concentration. Therefore, in addition to the effect of the titanium oxide particles, a clear color can be realized as compared with the conventional ink of this type.

In the present invention, the suspension added with an antibacterial agent also has the effect of suppressing the growth of dental caries, periodontal disease bacteria and the like in the oral cavity. Examples of the antibacterial agent to be blended include pionine, hinokitiol, wasabi extract, chitosan, catechin, propolis and benzalkonium chloride. The blending amount is within a range in which the state of the suspension and the action and effect are not impaired.
It is appropriately set in consideration of the physical properties and efficacy of the antibacterial agent.

Further, in the present invention, the tooth coloring ink to which the anti-cariogenic antibody and / or the periodontal disease antibody is added and blended is the same as the above-mentioned antibacterial agent, depending on the type and amount of the antibody. It has the effect of suppressing the growth of periodontal disease bacteria in the oral cavity.

Examples of the caries fungus antibody to be mixed include IgY antibody against Streptococcus mutans, IgY antibody against Streptococcus sobrinus, and IgY antibody against Raltobacillus. In addition, as the periodontal disease bacteria antibody to be blended, IgY antibody against Actinobacillus actinomycetemcomitans, IgY antibody against Polyphyrimonas gingivalis, IgY antibody against Fusobacterium nucletam, IgY antibody against Campylobacter rectus, Bacteroides. -IgY antibody against Forsythe and IgY antibody against Treponema denticola.

Each IgY antibody is obtained in the form of egg yolk powder. Although the antibody concentration in the egg yolk powder varies depending on the degree of purification, in order to sufficiently exert the effect against the dental caries or periodontal disease bacteria, 1 type of egg yolk powder in the tooth coloring ink is used.
It is preferable to use at least mass%. More preferably, it is 3% by mass or more.

The shellac-ethanol solution used as the substrate in the present invention is acidic. Therefore, when an aluminum-excited pigment is used, aluminum may undergo alcohol decomposition (alcoholsis) in a solution, the liquid may gradually gel, and finally the ink may solidify. In order to stably maintain the dispersed state of the suspension constituting the tooth coloring ink according to the present invention for a long period of time without causing the above inconvenience, when the colorant is an aluminum-excited pigment, The temperature of the suspension is maintained below 10 ℃ or the pH of the suspension
Is preferably kept weakly alkaline.

As a concrete means for maintaining the pH of the suspension weakly alkaline, a method of adding a small amount of calcium carbonate, barium phosphate, egg calcium or the like as a pH adjuster to the suspension, A method of storing the suspension in a soda glass container can be exemplified.

When a dye not excited with aluminum is used as the colorant, the colorant is first dissolved in an ethanol solution containing propylene glycol and glycerin fatty acid ester, and then titanium oxide powder is added and mixed. After that, the colorant particles are dispersed in the state of being adsorbed and bonded to the titanium oxide particles, and then the ethanol solution in which the shellac resin is dissolved is added and mixed to prepare a suspension, which maintains a stable dispersion state of the suspension. From the viewpoint of.

[0039]

EXAMPLES The present invention will be described in more detail based on the following examples, but the invention is not intended to be limited by the following examples. [Example 1] A pigment made of food red No. 3 dye excited with aluminum and titanium oxide powder were added to an anhydrous ethanol solution containing propylene glycol and glycerin fatty acid ester, and dispersed by stirring. An ethanol solution in which shellac resin was dissolved was added to and mixed with the liquid to prepare a suspension having the following composition to obtain a tooth coloring ink, which was stored in a soda glass container. Suspension composition (% by mass) Titanium oxide 30 Food red No. 3 5 Shellac 27 Propylene glycol 10 Glycerin fatty acid ester 1.5 Ethanol 26.5 When this ink was applied to the surface of the teeth in the oral cavity, the film formed was , Showed a clear red color. The color tone and depth of the color of this film did not change from the initial state even after 24 hours, and the detachment and outflow of the pigment to saliva was not observed.

[Example 2] An ink for coloring teeth was obtained in the same manner as in Example 1 except that a pigment consisting of aluminum-excited food yellow No. 4 dye was used as a colorant. Suspension composition (% by mass) Titanium oxide 30 Edible yellow No. 4 8 Shellac 26 Propylene glycol 9 Glycerin fatty acid ester 1.5 Ethanol 25.5 When this ink was applied to the tooth surface in the oral cavity, the film formed was , Showed a clear yellow color. The color tone and depth of the color of this film did not change from the initial state even after 24 hours, and the detachment and outflow of the pigment to saliva was not observed.

[Example 3] An ink for coloring teeth was obtained in the same manner as in Example 1 except that a pigment composed of food blue No. 1 dye excited with aluminum was used as the colorant. Suspension composition (% by mass) Titanium oxide 26 Food blue No. 1 5 Shellac 27 Propylene glycol 10 Glycerin fatty acid ester 1.5 Ethanol 26.5 When this ink was applied to the tooth surface in the oral cavity, the film formed was , Showed a clear blue color. The color tone and depth of this film is 2
After the lapse of 4 hours, there was no change from the initial state, and no detachment and outflow of the pigment to saliva or the like was observed.

[Comparative Example] A 3% by mass solution was prepared by dissolving a pigment consisting of food red No. 3 dye excited by aluminum in absolute ethanol. Shellac resin was dissolved in the solution to prepare a shellac-ethanol solution having the following composition to obtain a tooth coloring ink. This was stored in a soda glass container. Solution composition (mass%) Edible Red No. 3 3 Shellac 57 Ethanol 40 When this ink was applied to the surfaces of the teeth in the oral cavity, the film formed was a semi-transparent film in which the red color was faintly recognizable. It was The coating lost its gloss and turned cloudy after 3 hours.

[Reference Example] The tooth coloring inks obtained in Examples 1 to 3 were stored in a vinyl container immediately after preparation and left at room temperature of about 23 ° C. The change over time in the gelation rate (solidification rate) of each of these inks was measured with a rheometer. The result is shown in FIG. In addition, the liquid temperature of each ink similar to the above stored in a vinyl container is 0-20.
The gelation rate (solidification rate) after 10 weeks when the temperature was changed in the range of ° C was measured in the same manner as above. The result is shown in FIG.

As shown in FIG. 1, with each color ink,
After at least 5 weeks had elapsed, gelation started, and after 10 weeks, it had completely gelated. Further, as shown in FIG. 2, the ink of each color began to gel at a temperature of at least 14 ° C. and completely gelled at a temperature of 19 ° C. or higher.

[0045]

The tooth coloring ink according to the present invention is harmless in hygiene because it uses a shellac-ethanol solution as a base material. Further, due to the interaction between the titanium oxide particles and the pigment particles that are uniformly dispersed in the solution, when applied to the surface of the tooth, it is possible to form a robust film having a clear and sufficiently dark color. Further, the ink added with an antibacterial agent or an antibody against dental caries or an antibody against periodontal disease is
It also has the effect of suppressing the propagation of dental caries, periodontal bacteria, etc. in the oral cavity.

[Brief description of drawings]

FIG. 1 is a graph showing the relationship between the elapsed time and the gelation rate when the tooth coloring ink according to the present invention is stored in a vinyl container at room temperature.

FIG. 2 is a diagram showing the relationship between the change in liquid temperature and the gelation rate when the tooth coloring ink according to the present invention is stored in a vinyl container.

─────────────────────────────────────────────────── --Continued from the front page (58) Fields surveyed (Int.Cl. ⁷ , DB name) A61K ⁷ /00-7/50 A61K 6/00 C09D 11/16

Claims (12)

(57) [Claims] 1. Propylene glycol 1 mass% or more 30
Mass% or less, glycerin fatty acid ester 0.01 mass%
10 mass% or more and shellac 10 mass% or more 5
Shellac ethanol solution containing 0% by mass or less
An ink for coloring teeth, which comprises a suspension in which 1 part by mass or more and 40 parts by mass or less of titanium oxide powder and 0.1 parts by mass or more and 20 parts by mass or less of a colorant are uniformly dispersed in 00 parts by mass. . 2. The tooth coloring ink according to claim 1, wherein an aluminum-excited pigment is used as the colorant. 3. The tooth coloring ink according to claim 2, wherein the aluminum-excited pigment is an aluminum-excited pigment of a food dye. 4. The tooth coloring ink according to claim 3, wherein the food dye is at least one selected from food red No. 3, food yellow No. 4, and food blue No. 1. 5. The titanium oxide powder has an average particle size of 10
Claim 1 thru | or 4 characterized by being less than micrometer.
Ink for coloring teeth according to any one of 1. 6. The tooth coloring ink according to claim 1, further comprising an antibacterial agent. 7. The tooth coloring agent according to claim 6, wherein the antibacterial agent is at least one selected from pionine, hinokitiol, wasabi extract, chitosan, catechin, propolis and benzalkonium chloride. ink. 8. The tooth coloring ink according to any one of claims 1 to 5, further comprising at least one selected from a dental caries bacteria antibody and a periodontal disease bacteria antibody. 9. The method for storing tooth coloring ink according to claim 1, wherein the storage temperature is 10 ° C. or lower. 10. The method for storing a tooth coloring ink according to claim 1, wherein the pH of the tooth coloring ink is kept weakly alkaline. 11. A calcium carbonate as a pH adjuster,
10. The method for storing a tooth coloring ink according to claim 9, wherein at least one selected from barium phosphate and egg calcium is blended. 12. The method for storing tooth coloring ink according to claim 1, wherein the tooth coloring ink is stored in a soda glass container.