WO2018230325A1 - Composition destinée à être utilisée dans la cavité buccale - Google Patents

Composition destinée à être utilisée dans la cavité buccale Download PDF

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Publication number
WO2018230325A1
WO2018230325A1 PCT/JP2018/020506 JP2018020506W WO2018230325A1 WO 2018230325 A1 WO2018230325 A1 WO 2018230325A1 JP 2018020506 W JP2018020506 W JP 2018020506W WO 2018230325 A1 WO2018230325 A1 WO 2018230325A1
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WO
WIPO (PCT)
Prior art keywords
composition
zinc oxide
oil
hexagonal plate
oral cavity
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PCT/JP2018/020506
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English (en)
Japanese (ja)
Inventor
典浩 高下
卓 小倉
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ライオン株式会社
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Publication date
Application filed by ライオン株式会社 filed Critical ライオン株式会社
Priority to CN201880007910.9A priority Critical patent/CN110198699A/zh
Priority to KR1020197026233A priority patent/KR20200015449A/ko
Publication of WO2018230325A1 publication Critical patent/WO2018230325A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0254—Platelets; Flakes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a composition for oral cavity that has an excellent whitening effect on teeth.
  • (1) has a problem in safety
  • (2) to (4) there is room for improvement in terms of simplicity because a fixing means may be used for whitening the teeth.
  • Development of a simple and effective whitening technique for teeth was desired.
  • This invention is made
  • (A) hexagonal plate-like zinc oxide has an excellent whitening effect on teeth, and when this is blended into an oral composition, It has been found that it has an excellent whitening effect that makes it whiter than the color. That is, according to the present invention, by blending (A) hexagonal plate-like zinc oxide into the oral composition, an excellent tooth whitening effect is provided, thereby allowing normal tooth brushing and washing without using fixing means. It has been found that even with the mouth alone, the whiteness of the teeth stands out, the brightness of the teeth increases, and the teeth can appear much whiter than the original color, and the present invention has been made.
  • Hexagonal plate-like zinc oxide is known as a component of skin cosmetics such as foundations as an ultraviolet light inhibitor, but in preparations applied to the oral cavity, amorphous particles are generally used as zinc oxide. It was done. Therefore, single crystal particles are not applied as zinc oxide, and the composition of hexagonal plate-like zinc oxide into the oral composition has not been known so far.
  • (A) hexagonal plate-like zinc oxide, particularly preferably hexagonal plate-like zinc oxide having a specific average particle diameter and average thickness, is an excellent tooth in an oral composition. The whitening effect of the present invention is achieved, and there is a special effect that cannot be obtained by using other white pigments.
  • the present invention not only the above-described whitening effect but also an astringent feeling derived from zinc oxide can be appropriately imparted by the component (A) to give a good feeling of use.
  • gear using the zinc oxide which is a white pigment is well-known (patent document 3), as above-mentioned, the zinc oxide used for a composition for oral cavity is usually an amorphous particle. Even with zinc oxide, the effect of the present invention cannot be obtained with irregularly shaped particles. As shown in a comparative example described later, the whitening effect is inferior when an amorphous zinc oxide powder is used instead of the component (A), and even when it is a hexagonal plate, mica titanium may be used.
  • the whitening effect is inferior, and the effect of the present invention is inferior in these.
  • the effect of making the teeth whiter is excellent and the astringent feeling is satisfied by the contribution of the film-forming ability of the component (A) and the retention in the oral mucosa. It is speculated that it can also be granted.
  • the present invention provides the following oral composition.
  • (A) A composition for oral cavity containing hexagonal plate-like zinc oxide.
  • [2] The oral composition according to [1], wherein the hexagonal plate-like zinc oxide has an average particle size of 0.1 to 10 ⁇ m.
  • [3] The oral composition according to [1] or [2], wherein the hexagonal plate-like zinc oxide has an average thickness of 0.01 to 1 ⁇ m.
  • [4] The composition for oral cavity according to any one of [1] to [3], wherein the average particle diameter / average thickness is 0.5 to 50 and represents the ratio between the average particle diameter and the average thickness of hexagonal plate-like zinc oxide .
  • composition for oral cavity according to [5] which is a dentifrice or mouthwash.
  • an oral composition having an excellent whitening effect on teeth can be provided.
  • the composition for oral cavity of the present invention can be effectively used for whitening teeth because it can easily and effectively whiten teeth and make the teeth whiter than the original color.
  • (A) hexagonal plate-like zinc oxide is blended in an oral composition as an active ingredient for whitening teeth.
  • Hexagonal plate-like zinc oxide has a whitening effect on teeth and gives a sense of convergence.
  • the hexagonal plate-like zinc oxide is not particularly limited as long as it is hexagonal and plate-like particles, and known single crystal hexagonal plate-like zinc oxide can be used.
  • the hexagonal plate-like zinc oxide can be used by being dispersed in water.
  • the average particle size of the hexagonal plate-like zinc oxide is preferably 0.1 ⁇ m or more, more preferably 0.5 ⁇ m or more, still more preferably 1 ⁇ m or more, particularly 1.5 ⁇ m or more, and preferably 10 ⁇ m or less, more preferably It is 8 ⁇ m or less, more preferably 5 ⁇ m or less. When it is 0.1 ⁇ m or more, the whitening effect is sufficiently exhibited. When the thickness is 10 ⁇ m or less, the convergence feeling is sufficiently exhibited.
  • the “particle size” of the hexagonal plate-like zinc oxide in the present invention is an average value of the lengths of the three diagonal lines of the hexagonal surface of the hexagonal plate-like particle.
  • the average particle size was calculated by image analysis, specifically, by randomly selecting 20 hexagonal plate-like zinc oxides, and measuring and averaging the lengths of the diagonal lines of each particle.
  • a scanning electron microscope (SEM) JSM7600F manufactured by JEOL Ltd. was used for the particle size measurement.
  • the particle size of each particle was measured by averaging the lengths of three hexagonal diagonal lines from the image from the Z-axis direction (the same applies hereinafter).
  • the average thickness of the hexagonal plate-like zinc oxide is preferably 0.01 ⁇ m or more, more preferably 0.1 ⁇ m or more, still more preferably 0.2 ⁇ m or more, and preferably 1 ⁇ m or less, more preferably 0.8 ⁇ m or less. More preferably, it is 0.7 ⁇ m or less.
  • the “thickness” of hexagonal plate-like zinc oxide in the present invention is a distance between two hexagonal surfaces of hexagonal plate-like particles.
  • said average thickness uses the scanning electron microscope (SEM) JSM7600F by JEOL Co., Ltd., 20 hexagonal plate-like zinc oxides were selected at random, and each particle
  • SEM scanning electron microscope
  • the hexagonal plate-like zinc oxide shows the ratio between the average particle diameter and the average thickness, and the average particle diameter / average thickness is preferably 0.5 or more, more preferably 1 or more, and further preferably 2 or more. Moreover, 50 or less is preferable, More preferably, it is 30 or less, and may be 5 or less. When the average particle size / average thickness is 0.5 or more, the whitening effect is sufficiently exhibited. When it is 50 or less, a feeling of convergence is sufficiently exhibited.
  • the oil absorption amount of hexagonal plate-like zinc oxide is preferably 45 g / 100 g or less, more preferably 36 g / 100 g or less.
  • the oil absorption was measured according to JIS K-5101-13-1.
  • hexagonal plate-like zinc oxide commercially available products can be used. Examples include hexagonal plate-like zinc oxide XZ series XZ-100F, XZ-300F, XZ-1000F, XZ-2000F, and XZ-3000F (all manufactured by Sakai Chemical Industry Co., Ltd.).
  • the compounding quantity of hexagonal plate-shaped zinc oxide is not restrict
  • the blending amount of the component (A) is preferably 0.1 to 30%, particularly preferably 0.1 to 20%, more preferably 0.1 to 5% of the whole composition, More preferably, it is 0.5 to 3%, and particularly preferably 1.0 to 2%.
  • the composition for oral cavity of this invention can be prepared also in sheet-like forms, such as a pack agent and a film agent, as mentioned later, in such a sheet-form preparation, (A) component is compared compositionally. Can be blended as much as possible.
  • the blending amount of the component (A) can be 0.1 to 95% of the whole composition from the viewpoint of the whitening effect and the feeling of use, but is preferably 0.1 to 20%, more preferably 0.1 to 5%.
  • (B) a surfactant it is preferable to further blend (B) a surfactant.
  • (B) a surfactant is added, the dispersibility of the component (A) is improved and the whitening effect is further increased.
  • surfactant examples include known anionic surfactants, nonionic surfactants, and amphoteric surfactants for oral use, and any of them may be used.
  • anionic surfactants include alkyl sulfates such as sodium lauryl sulfate, N-acyl sarcosine salts such as N-lauroyl sarcosine sodium, acyl amino acid salts such as N-acyl glutamate, and ⁇ -olefin sulfonic acids. Sodium etc. are mentioned.
  • Nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters such as decaglyceryl monolaurate, and average added moles of ethylene oxide ( And polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil having an EO) of 10 to 60, fatty acid alkanolamides such as polyoxyethylene higher alcohol ethers and lauric acid diethanolamide.
  • sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters such as decaglyceryl monolaurate, and average added moles of ethylene oxide ( And polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil having an EO) of 10 to 60, fatty acid
  • amphoteric surfactants include betaine types such as alkylbetaines, alkyldimethylaminoacetic acid betaines, fatty acid amidopropyl betaines, fatty acid amidopropyldimethylaminoacetic acid betaines, betaine types such as alkylimidazolinium betaines, and N-fatty acid acyl-N.
  • examples include imidazoline type such as -carboxymethyl-N-hydroxyethylethylenediamine salt.
  • anionic surfactants are particularly preferable, anionic surfactants having a sulfonic acid group are more preferable, and alkyl sulfates and ⁇ -olefin sulfonates are more preferable.
  • the blending amount of the (B) surfactant is preferably from 0.1 to 10%, particularly preferably from 1 to 5%, based on the entire composition.
  • the composition for oral cavity of the present invention can be made into paste, gel, liquid such as liquid, solid, etc., and prepared as a toothpaste such as toothpaste, liquid dentifrice, liquid dentifrice, mouthwash, etc. obtain. Furthermore, it is also possible to prepare a form that can be applied to teeth without using a fixing means, specifically, a sheet-form oral preparation such as a pack or film. In particular, dentifrices or mouthwashes are preferred in terms of the manifestation and usability of this effect.
  • the pack agent is a preparation in which the plaster surface of a sheet is attached to a tooth, the support is peeled off, the plaster is transferred onto the tooth surface, and the plaster is used as a dentifrice or the like.
  • a film agent is a preparation in which the entire film is used as a dentifrice etc. by sticking the film to the tooth surface and brushing as it is.
  • a tooth having a length of 2.5 cm, a width of 2 cm, and a thickness of about 0.3 mm The size and shape can be adjusted.
  • components that are commonly blended for oral compositions can be blended as necessary, depending on the form and the like. It can be prepared by conventional methods. For example, abrasives, thickeners, binders, sweeteners, preservatives, colorants, fragrances, active ingredients other than the component (A), and the like can be blended.
  • various gelling agents can also be used in order to gelatinize and paste and to improve the applicability to a tooth and adhesiveness with a tooth.
  • abrasive examples include silica-based abrasives such as precipitated silica, aluminosilicate, zirconosilicate, calcium phosphate-based abrasives, calcium carbonate and the like (the amount is usually 2 to 50%, particularly 10 to 40%). ).
  • wetting agent examples include sugar alcohols such as sorbit and xylite, glycerin, propylene glycol, and polyhydric alcohols such as polyethylene glycol having an average molecular weight of 160 to 4000 (average molecular weight described in Quasi-drug Raw Material Standard 2006). (The amount is usually 5 to 50%).
  • binders include cellulose derivatives such as sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, alginic acid or its derivatives such as sodium alginate, gums such as xanthan gum, organic binders such as carrageenan, polyvinyl alcohol, and sodium polyacrylate. And inorganic binders such as an agent, gelling silica, gelling aluminum silica, bee gum, and laponite (the blending amount is usually 0.1 to 10%).
  • sweetening agent examples include sodium saccharin
  • preservative examples include paraoxybenzoic acid esters such as methyl paraoxybenzoate, benzoic acid such as sodium benzoate, and salts thereof.
  • colorant examples include blue No. 1, yellow No. 4, titanium dioxide and the like.
  • Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, bran oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfumes, etc.) and menthol, Rubon, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-l-Ment
  • Active ingredients include fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate, cationic fungicides such as isopropylmethylphenol and cetylpyridinium chloride, enzymes such as anti-inflammatory agents and dextranase, and water-soluble phosphoric acid. Examples thereof include compounds, copper compounds, vitamins, plant extracts, calculus inhibitors, and plaque inhibitors.
  • the active ingredient can be blended in an effective amount as long as the effects of the present invention are not hindered.
  • the same material as the above-mentioned binder can be used as a gelling agent, but from the viewpoint of use feeling in the mouth, sodium carboxymethylcellulose, hydroxyethylcellulose, Cellulose derivatives such as hydroxypropyl cellulose, polyvinyl alcohol, and sodium alginate are preferred (the amount is preferably 1 to 5%).
  • the sheet-form oral preparation is not particularly limited as long as it can be applied to teeth, and there is no particular limitation on the shape, thickness, etc., usage form, and the like, even in a form that can be applied to one or more tooth surfaces.
  • it can also be used as a dentifrice by sticking on the tooth surface and brushing as it is after use.
  • the plaster composition is spread and integrated on the support so that the plaster composition is peelable.
  • a water-insoluble material is preferably used, and examples thereof include films, nonwoven fabrics, woven fabrics, and mesh fabrics of materials such as polypropylene, polyethylene, and polyurethane.
  • the film may be a single layer or a laminated film, or a laminated sheet of a film and unemployed cloth, woven cloth or net cloth.
  • the plaster composition may be protected by coating a release liner. These can use a commercial item.
  • Examples and Comparative Examples Prepare aqueous dispersions (simple systems) having the compositions shown in Tables 1 and 2 and dentifrices, mouth washes, packs or film preparations (formulation systems) having the compositions shown in Tables 3 to 7, respectively. Evaluation was performed by the method shown. The results are shown in the table.
  • the average particle diameter and average thickness of the samples used are shown in the table.
  • Zinc oxide powder, comparative product
  • Amorphous powder Japanese Pharmacopoeia zinc oxide, manufactured by Sakai Chemical Industry Co., Ltd., amorphous Average particle size 2 ⁇ m, average thickness 2 ⁇ m, oil absorption 59g / 100g Mica titanium (hexagonal plate, comparative product); TIMIRON MP-149, manufactured by Merck Ltd., single crystal, Average particle size 2 ⁇ m, average thickness 0.5 ⁇ m
  • the measuring method of said average particle diameter and average thickness is shown below. Measuring the average particle size; It was calculated by image analysis, and measured and analyzed in the same manner as described above using a scanning electron microscope (SEM) JSM7600F manufactured by JEOL. From the image from the Z-axis direction, the lengths of the three diagonal lines of the hexagon were measured to obtain the particle size, and the average particle size was calculated. Average thickness measurement method; Using a scanning electron microscope (SEM) JSM7600F manufactured by JEOL Ltd., measurement was performed in the same manner as described above, and an average value was obtained. The length of the plate-like upper and lower surfaces of the particles was measured to obtain the thickness, and the average thickness was calculated.
  • SEM scanning electron microscope
  • the measuring method of the average particle diameter of zinc oxide (hexagonal plate shape) and mica titanium (hexagonal plate shape) and average thickness is as described above, respectively, and the average particle size of zinc oxide (powdered shape) is The average thickness is measured by a laser diffraction scattering type particle size distribution measuring apparatus LA-920 manufactured by HORIBA, Ltd. Since the shape of zinc oxide (powder) is nearly spherical, the average particle size is defined as the average thickness for convenience. did. The oil absorption was measured according to JIS K-5101-13-1.
  • FIG. 1 shows a two-dimensional image of (A) zinc oxide (hexagonal plate) (taken using a scanning electron microscope (SEM) JSM7600F manufactured by JEOL Ltd.).
  • Evaluation method-1 Lightness measurement method of hydroxyapatite (HAP) plate and evaluation method of degree of whiteness (simple system) Zinc oxide was weighed and dispersed in 100 ml of water. A hydroxyapatite (HAP) plate having a diameter of 7 mm was put in this dispersion, and after 3 minutes, the HAP plate was taken out and lightly rinsed with 100 ml of water. This HAP plate was measured with a color difference meter (spectral color difference meter SE-2000, manufactured by Nippon Denshoku Industries Co., Ltd.) to obtain a value of ⁇ L which is an index of brightness. As a control, an untreated product (untreated HAP plate) was measured in the same manner.
  • the comparative example was similarly measured according to the above method.
  • a questionnaire was conducted on the degree of whiteness of the HAP plate for 10 subjects.
  • a score (1 to 4 points) was assigned based on the following criteria, and an average value was calculated from the obtained results. From the calculated average score, the degree of whiteness of the HAP plate was evaluated based on the following evaluation criteria.
  • An untreated HAP plate was used as a control.
  • Evaluation method-2 Lightness measurement method of hydroxyapatite (HAP) plate and evaluation method of degree of whiteness (formulation system) Dentifrices, packs (plasters), and film preparations were diluted three times with water to prepare a dispersion of about 100 ml, which was used as an evaluation solution. The mouthwash was directly used as an evaluation solution. A hydroxyapatite (HAP) plate having a diameter of 7 mm was put in this dispersion, and after 3 minutes, the HAP plate was taken out and lightly rinsed with 100 ml of water.
  • HAP hydroxyapatite
  • This HAP plate was measured with a color difference meter (spectral color difference meter SE-2000, manufactured by Nippon Denshoku Industries Co., Ltd.) to obtain a value of ⁇ L which is an index of brightness.
  • a color difference meter spectral color difference meter SE-2000, manufactured by Nippon Denshoku Industries Co., Ltd.
  • ⁇ L an index of brightness
  • an untreated product untreated HAP plate
  • the comparative example was similarly measured according to the above method. Further, the degree of whiteness of the HAP plate was evaluated in the same manner as in the evaluation method-1.
  • Evaluation method-3 Evaluation method of astringency (formulation system) A questionnaire was conducted on 10 subjects about the degree of convergence after using each preparation. A score (1 to 4 points) was assigned based on the following criteria, and an average value was calculated from the obtained results. Based on the average value of the calculated scores, the degree of convergence after brushing was evaluated based on the following evaluation criteria. In each dentifrice, tooth brushing was performed for each subject by taking about 1 g of the dentifrice composition on a toothbrush, brushing for 3 minutes, and rinsing the oral cavity with water. The other preparations were used in the usual manner.
  • the pack agent was prepared in the same shape by the same method as the adhesive sheet in the examples of JP-A-2016-117682, except that the plaster composition and the support having the above composition were used.
  • the plaster composition was applied to a support, and spread while being sandwiched between the support and a silicone coating surface of a release liner (BD binder of film binder 75E-001 manufactured by Fujimori Kogyo Co., Ltd.).
  • the obtained sheet was punched out for the upper jaw (width (parallel to the dentition) 62 mm, length 24 mm) and lower jaw (width 52 mm, height 24 mm), and cut and folded lines were also prepared. .
  • the pack agent was affixed to the tooth surface and the support was peeled off, it was used after brushing.
  • the film agent was prepared in a size of 2.5 cm in length, 2 cm in width, and 0.3 mm in thickness by a usual method. After the film agent was applied to the tooth surface, it was used after brushing.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition destinée à être utilisée dans la cavité buccale qui est caractérisée en ce qu'elle contient (A) un oxyde de zinc de type plaque hexagonale. La présente invention permet de produire une composition destinée à être utilisée dans la cavité buccale présentant un excellent effet de blanchiment des dents.
PCT/JP2018/020506 2017-06-15 2018-05-29 Composition destinée à être utilisée dans la cavité buccale WO2018230325A1 (fr)

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CN201880007910.9A CN110198699A (zh) 2017-06-15 2018-05-29 口腔用组合物
KR1020197026233A KR20200015449A (ko) 2017-06-15 2018-05-29 구강용 조성물

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JP2017-117531 2017-06-15
JP2017117531A JP2019001747A (ja) 2017-06-15 2017-06-15 口腔用組成物

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WO2018230325A1 true WO2018230325A1 (fr) 2018-12-20

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022083996A1 (fr) 2020-10-22 2022-04-28 Unilever Ip Holdings B.V. Composition de soins buccodentaires avec avantages de blanchiment

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JPS5467596A (en) * 1977-11-09 1979-05-31 Matsushita Electric Ind Co Ltd Preparation of hexagonal plate zinc oxide crystal powder
JP2003183142A (ja) * 2001-12-19 2003-07-03 Lion Corp 歯牙の白色化方法及び歯牙白色化組成物
US20090017303A1 (en) * 2007-06-12 2009-01-15 Fas Alliances, Inc. Zinc oxide having enhanced photocatalytic activity
WO2015118777A1 (fr) * 2014-02-07 2015-08-13 堺化学工業株式会社 Particules d'oxyde de zinc en forme de plaques hexagonales, leur procédé de production, produit cosmétique, charge, composition de résine, matériau réfléchissant dans l'infrarouge, et composition de revêtement

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JPS483155Y1 (fr) 1970-10-08 1973-01-26
JP3997371B2 (ja) 1999-01-28 2007-10-24 ライオン株式会社 歯の美白用セット
JP4548582B2 (ja) 2004-06-22 2010-09-22 ライオン株式会社 歯牙美白用セット
PL1837009T3 (pl) * 2006-03-22 2009-10-30 Procter & Gamble Doustne kompozycje zawierające cynk
JP4919009B2 (ja) 2006-06-23 2012-04-18 ライオン株式会社 歯の化粧セット

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Publication number Priority date Publication date Assignee Title
JPS5467596A (en) * 1977-11-09 1979-05-31 Matsushita Electric Ind Co Ltd Preparation of hexagonal plate zinc oxide crystal powder
JP2003183142A (ja) * 2001-12-19 2003-07-03 Lion Corp 歯牙の白色化方法及び歯牙白色化組成物
US20090017303A1 (en) * 2007-06-12 2009-01-15 Fas Alliances, Inc. Zinc oxide having enhanced photocatalytic activity
WO2015118777A1 (fr) * 2014-02-07 2015-08-13 堺化学工業株式会社 Particules d'oxyde de zinc en forme de plaques hexagonales, leur procédé de production, produit cosmétique, charge, composition de résine, matériau réfléchissant dans l'infrarouge, et composition de revêtement

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IZUKA, YOSHINOBU ET AL.: "Effects of anionic surfactant on shape of zinc oxide particle", LECTURE ABSTRACTS OF THE 2015 RESEARCH PRESENTATION OF COLOR MATERIALS, 2015, pages 82 - 83 *
J AVIDI, M. ET AL.: "Zinc oxide nano-particles as sealer in endodontics and its sealing ability", CONTEMPORARY CLINICAL DENTISTRY, vol. 5, no. 1, January 2014 (2014-01-01), pages 20 - 24, Retrieved from the Internet <URL:doi:10.4103/0976-237X.128656> *
YOSHIDA, RYOHEI: "Multifunctional zinc oxide evolving make-up cosmetics", FRAGRANCE JOURNAL, vol. 43, December 2015 (2015-12-01), pages 31 - 35 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022083996A1 (fr) 2020-10-22 2022-04-28 Unilever Ip Holdings B.V. Composition de soins buccodentaires avec avantages de blanchiment

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KR20200015449A (ko) 2020-02-12
CN110198699A (zh) 2019-09-03

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