JP6903501B2 - Oral composition - Google Patents

Description

The present invention relates to an oral composition and the like, and more particularly to an O / D type emulsified oral composition and the like.

An emulsification technique (D-phase emulsification method) using a surface science technique is known as a technique for obtaining an O / W type emulsion of fine oil droplets. This emulsification technique is an emulsification method using a surfactant phase, which is also called a D phase. The oil of the dispersed phase is dispersed and held in the surfactant phase (in the D phase) to produce an O / D type emulsified composition, which is diluted with water to obtain an O / W type composition. The O phase represents an oil phase (oil phase), the W phase represents a water phase (aqueous phase), and the D phase represents a detergent phase (surfactant phase).

As described above, the O / D type emulsified composition has been mainly used as a raw material (intermediate) for obtaining the O / W type composition (for example, Patent Documents 1 and 2). However, the O / D type emulsified composition is, so to speak, a lump of oil and a surfactant, and it seems that the feeling of use is very poor (particularly, the surfactant may irritate the living body). Therefore, there are few examples of using the O / D type emulsified composition itself as a product (particularly a product applied to a living body).

Japanese Unexamined Patent Publication No. 2014-189550 JP-A-2009-95253

An object of the present invention is to provide a product using an O / D type emulsified composition.

The present inventors have found that when the O / D type emulsified composition is applied into the oral cavity, an unexpectedly favorable feeling of use can be obtained, and further improvements have been made to complete the present invention.

The present invention includes, for example, the subjects described in the following sections.
Item 1.
An O / D type emulsified oral composition containing a hydrocarbon oil, a polyhydric alcohol, and a surfactant.
Item 2.
Item 2. The O / D type emulsified oral composition according to Item 1, wherein the water content is 0.5% by mass or less.
Item 3.
Item 2. The O / D type emulsified oral composition according to Item 1 or 2, which is substantially free of water.
Item 4.
Item 2. The O / D type emulsified oral composition according to any one of Items 1 to 3, which is not phase-separated by standing at 25 ° C. for 1 week after preparation.
Item 5.
Item 2. The O / D type emulsified oral composition according to any one of Items 1 to 4, wherein the polyhydric alcohol is at least one polyhydric alcohol selected from the group consisting of a divalent alcohol and a trihydric alcohol. ..
Item 6.
Item 2. The O / D type emulsified oral composition according to any one of Items 1 to 5, wherein the hydrocarbon oil is at least one hydrocarbon oil selected from the group consisting of squalane and paraffin.
Item 7.
Surface active agents are polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid glyceryl, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene hydrogenated castor oil, Item 2. The O / D type emulsified oral composition according to any one of Items 1 to 6, which is at least one selected from the group consisting of polyoxyethylene sterol and polyoxyethylene sterol.
Item 8.
An O / D type emulsified composition containing a hydrocarbon oil, a polyhydric alcohol, and a surfactant, which are carriers for an oral composition.
Item 9.
Item 8. The O / D type emulsified composition according to Item 8, wherein the water content is 0.5% by mass or less.
Item 10.
Item 8. The O / D type emulsified composition according to Item 8 or 9, which is substantially free of water.
Item 11.
Item 8. The O / D type emulsified composition according to any one of Items 8 to 10, which is not phase-separated by standing at 25 ° C. for 1 week after preparation.
Item 12.
Item 2. The O / D type emulsified oral composition according to any one of Items 8 to 11, wherein the polyhydric alcohol is at least one polyhydric alcohol selected from the group consisting of a divalent alcohol and a trihydric alcohol. ..
Item 13.
Item 2. The O / D type emulsified oral composition according to any one of Items 8 to 12, wherein the hydrocarbon oil is at least one hydrocarbon oil selected from the group consisting of squalane and paraffin.
Item 14.
Surfactants include polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid glyceryl, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene hydrogenated castor, and Item 2. The O / D type emulsified oral composition according to any one of Items 8 to 13, which is at least one selected from the group consisting of polyoxyethylene sterol oil.

A product (oral composition) using the O / D type emulsified composition is provided. By using the O / D type emulsified oral composition, an unexpectedly excellent usability can be obtained. In particular, even when the oral composition contains a polyhydric alcohol, the burning sensation peculiar to the polyhydric alcohol is suppressed. In addition, a feel peculiar to the O / D type emulsified composition can be obtained in the oral cavity.

Hereinafter, each embodiment of the present invention will be described in more detail.

The oral composition included in the present invention comprises an O / D type emulsified composition. In other words, the oral composition included in the present invention is an O / D type emulsified oral composition.

The O / D type emulsified oral composition contains a hydrocarbon oil, a polyhydric alcohol, and a surfactant. The hydrocarbon oil is contained in the O phase, and the polyhydric alcohol and the surfactant are contained in the D phase.

On the other hand, it is preferable that the O / D type emulsified oral composition is substantially free of water. Substantially water-free means that water is not used as a raw material in the preparation. However, since some raw materials (for example, polyhydric alcohols and hydrocarbon oils) contain water in a very small amount, the obtained O / D type emulsified oral composition contains a very small amount of water derived from the raw material. In some cases. The O / D type emulsified oral composition containing a very small amount of water derived from this raw material is included in the "substantially water-free O / D type emulsified oral composition".

More specifically, when water derived from the raw material is contained in the O / D type emulsified oral composition, the content thereof is more than 0% by mass and about 0.5% by mass or less, more preferably 0% by mass. More, about 0.4% by mass or less.

Examples of the hydrocarbon oil include squalane, paraffin, microcrystalline wax, petrolatum, ceresin, limonene, turpentine and the like. In particular, known hydrocarbon oils used in oral compositions are preferable, and squalane and paraffin are particularly preferable. As the squalane, both animal squalane and plant squalane can be used, and for example, shark squalane, olive squalane and the like can be preferably used. Further, as paraffin, liquid paraffin is preferable. The hydrocarbon oil may be used alone or in combination of two or more.

As the polyhydric alcohol, a divalent or trivalent alcohol is preferably exemplified. At least one polyhydric alcohol selected from the group consisting of divalent alcohols and trihydric alcohols can be preferably used. The divalent alcohol and the trihydric alcohol are not particularly limited, and examples thereof include ethylene glycol, propanediol, diethylene glycol, polyethylene glycol, 1,3-butylene glycol, and glycerin. As the propanediol, either propylene glycol (1,2-propanediol) or 1,3-propanediol can be preferably used. Of these, propylene glycol, 1,3-propanediol, 1,3-butylene glycol, and glycerin are preferable, and propylene glycol and glycerin are particularly preferable. The polyhydric alcohol may be used alone or in combination of two or more.

As the surfactant, a nonionic surfactant is preferable. The nonionic surfactant is not particularly limited, but more specifically, for example, polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid glyceryl, polyoxyethylene alkyl ether, etc. Polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene sterol and the like are preferably mentioned. The surfactant (particularly a nonionic surfactant) can be used alone or in combination of two or more.

Examples of the polyglycerin fatty acid ester include 8 to 24 carbon atoms (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, or 24). ) Saturated or unsaturated fatty acid and an ester compound of polyglycerin are preferable.

The fatty acid has more preferably 8 to 22 carbon atoms, still more preferably 10 to 20 carbon atoms, and even more preferably 12 to 18 carbon atoms. Further, the fatty acid may be a saturated fatty acid or an unsaturated fatty acid, and in the case of an unsaturated fatty acid, the number of carbon-carbon double bonds is preferably 1, 2, 3, or 4, 1 or 2. Is more preferable. As the fatty acid, for example, capric acid, lauric acid, myristic acid, palmitic acid, palmitic acid, margaric acid, oleic acid, linoleic acid, bechenic acid and the like are preferably exemplified, and among them, capric acid, lauric acid, myristic acid and palmitic acid. , Oleic acid is preferred. In addition, natural fatty acids such as coconut oil fatty acid and palm oil fatty acid containing these fatty acids may be used.

In addition, the polyglycerin may contain an average of 4 to 12 (4, 5, 6, 7, 8, 9, 10, 11, or 12) glycerin units (-OCH ₂ CH (OH) CH _2- ). It is preferable to contain an average of 5 to 10 glycerin units.

More specifically, as preferred polyglycerin fatty acid esters, for example, polyglyceryl caprate-n ¹ , polyglyceryl laurate-n ¹ , polyglyceryl myristate-n ¹ , polyglyceryl stearate-n ¹ , polyglyceryl oleate-n ¹ , (N ¹ here represents the number of glycerin units, preferably 4 to 12, particularly preferably 5 or 10 as described above) and the like.

Examples of the polyethylene glycol fatty acid ester include 8 to 24 carbon atoms (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, or 24). ) Saturated or unsaturated fatty acid and polyethylene glycol ester compound is preferable.

The fatty acid has more preferably 8 to 22 carbon atoms, still more preferably 10 to 20 carbon atoms, and even more preferably 12 to 18 carbon atoms. Further, the fatty acid may be a saturated fatty acid or an unsaturated fatty acid, and in the case of an unsaturated fatty acid, the number of carbon-carbon double bonds is preferably 1, 2, 3, or 4, 1 or 2. Is more preferable. As the fatty acid, for example, capric acid, lauric acid, myristic acid, palmitic acid, palmitic acid, margaric acid, oleic acid, linoleic acid, bechenic acid and the like are preferably exemplified, and among them, capric acid, lauric acid, myristic acid and palmitic acid. , Oleic acid is preferred. In addition, natural fatty acids such as coconut oil fatty acid and palm oil fatty acid containing these fatty acids may be used.

In addition, the polyethylene glycol has an average number of moles of ethylene oxide units (EO) of 4 to 20 (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, It is preferably 18, 19, or 20), and more preferably 5 to 15.

Preferred polyethylene glycol fatty acid esters, more specifically, for example, ^{PEG-n 2} stearate, laurate ^{PEG-n 2 (n 2} here represents the average added mole number of EO, the street 4 of 20 is preferable, and 5 to 15 is more preferable) and the like.

Examples of the polyoxyethylene sorbitan fatty acid ester include 8 to 24 carbon atoms (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, Alternatively, an ester compound of the saturated or unsaturated fatty acid of 24) and the polyethylene glycol ether of sorbitol is preferable.

The fatty acid has more preferably 8 to 22 carbon atoms, still more preferably 10 to 20 carbon atoms, and even more preferably 12 to 18 carbon atoms. Further, the fatty acid may be a saturated fatty acid or an unsaturated fatty acid, and in the case of an unsaturated fatty acid, the number of carbon-carbon double bonds is preferably 1, 2, 3, or 4, 1 or 2. Is more preferable. Examples of the fatty acid are preferably capric acid, lauric acid, myristic acid, palmitic acid, palmitic acid, margaric acid, oleic acid, linoleic acid, bechenic acid and the like, and among them, capric acid, lauric acid, myristic acid and palmitic acid. , Oleic acid is preferred. In addition, natural fatty acids such as coconut oil fatty acid and palm oil fatty acid containing these fatty acids may be used.

Further, in the polyoxyethylene, the average number of moles of ethylene oxide units (EO) added is preferably about 20 to 80, more preferably about 25 to 70, and even more preferably about 30 to 60. ..

Further, as the polyoxyethylene sorbitan fatty acid ester, a mono, di, tri, tetra, penta, or cycloester compound of the fatty acid and polyethylene glycol ether of sorbitol is preferable, and a tri or tetra ester compound is more preferable.

Preferred polyoxyethylene sorbitan fatty acid esters, more specifically, for example, n ³ of tetraoleate sorbeth -n 3 ^(here represents the average added mole number of EO, is as 20 to 80 of the It is preferably about 25 to 70, more preferably about 30 to 60) and the like.

Polyoxyethylene fatty acid glyceryl is a polyethylene glycol ether of fatty acid glyceryl (monoester of fatty acid and glycerin), for example, having 8 to 24 carbon atoms (8, 9, 10, 11, 12, 13, 14, 15, 16). , 17, 18, 19, 20, 21, 22, 23, or 24) is preferably a monoester of saturated or unsaturated fatty acid and glycerin with polyethylene glycol bonded (ether bond).

The fatty acid has more preferably 8 to 22 carbon atoms, still more preferably 10 to 20 carbon atoms, and even more preferably 12 to 18 carbon atoms. Further, the fatty acid may be a saturated fatty acid or an unsaturated fatty acid, and in the case of an unsaturated fatty acid, the number of carbon-carbon double bonds is preferably 1, 2, 3, or 4, 1 or 2. Is more preferable. Examples of the fatty acid are preferably capric acid, lauric acid, myristic acid, palmitic acid, palmitic acid, margaric acid, oleic acid, linoleic acid, bechenic acid and the like, and among them, capric acid, lauric acid, myristic acid and palmitic acid. , Oleic acid is preferred. In addition, natural fatty acids such as coconut oil fatty acid and palm oil fatty acid containing these fatty acids may be used.

Further, in the polyoxyethylene, the average number of moles of ethylene oxide units (EO) added is preferably about 3 to 200, more preferably about 5 to 50, and even more preferably about 5 to 30. ..

Further, as the polyoxyethylene fatty acid glyceryl, it is preferable that only one of the two hydroxyl groups of the fatty acid glyceryl is ether-bonded to polyethylene glycol.

Preferred polyoxyethylene fatty acid glyceryl be, more specifically, for example, n ⁴ of stearic acid PEG-n ⁴ glyceryl (here represents the average added mole number of EO, is about 3 to 200 as the , More preferably about 5 to 50, and even more preferably about 5 to 30).

As a polyoxyethylene alkyl ether, the alkyl group has 8 to 24 carbon atoms (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, Or 24) is preferable. It is more preferably 8 to 22, still more preferably 10 to 20, and even more preferably 12 to 18. Further, the alkyl group can be linear or branched chain, and more preferably linear.

The average number of moles of ethylene oxide unit (EO) added is preferably about 2 to 100, more preferably about 2 to 50, and even more preferably about 2 to 40.

More specifically, as preferred polyoxyethylene alkyl ethers, for example, POE (n ⁵ ) lauryl ether, POE (n ⁵ ) cetyl ether, POE (n ⁵ ) stearyl ether, POE (n ⁵ ) behenyl ether, POE ( n ⁵ ) Oleyl ether (n ⁵ here represents the average number of moles of EO added, preferably about 2 to 100 as described above, more preferably about 2 to 50, and about 2 to 40. Is more preferable) and the like. It is also possible to use a mix of at least two or more of these.

As a polyoxyethylene polyoxypropylene alkyl ether, the alkyl group has 8 to 24 carbon atoms (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22). , 23, or 24) is preferable. It is more preferably 8 to 22, still more preferably 10 to 20, and even more preferably 12 to 18. In addition, the alkyl group may be linear or branched.

The average number of moles of ethylene oxide unit (EO) added is preferably about 2 to 100, more preferably about 2 to 50, and even more preferably about 2 to 40. The average number of moles of propylene oxide unit (PO) added is preferably about 2 to 12, more preferably about 2 to 10, and even more preferably about 4 to 8.

More specifically, as preferable polyoxyethylene polyoxypropylene alkyl ethers, for example, PPG-y ceteth-x, PPG-y decyltetradeceth-x (where x represents the average number of moles of EO added). As described above, it is preferably about 2 to 100, more preferably about 2 to 50, further preferably about 2 to 40, and y here represents the average number of moles of PO added. As described above, it is preferably about 2 to 12, more preferably about 2 to 10, and even more preferably about 4 to 8).

As the polyoxyethylene hydrogenated castor oil, POE (n ⁶ ) cured castor oil (where n ⁶ represents the average number of moles of EO added, preferably about 10 to 150, more preferably about 15 to 130, 20 to 20 About 120 is more preferable) can be preferably exemplified. This can also be described as PEG-n ^{6 hydrogenated castor oil.}

As the polyoxyethylene sterol, PEG-n ⁷ phytosterol (where n ⁷ represents the average number of moles of EO added, is preferably about 5 to 100, more preferably about 5 to 50, still more preferably about 10 to 40. ) Can be preferably exemplified.

Further, as the surfactant (particularly nonionic surfactant), one having a relatively large HLB (Hydrophyllic-Lipopillic Balance) is preferable, for example, 11 or more is preferable, 12 or more is more preferable, 13 or more is further preferable, and 14 The above is even more preferable, and 15 or more is particularly preferable. The upper limit of HLB is not particularly limited, but for example, 20 or less can be exemplified.

The content ratio of the hydrocarbon oil and the surfactant in the O / D type emulsified oral composition is, for example, preferably about 5 to 70 parts by mass with respect to 1 part by mass of the surfactant, and 6 to 70 parts by mass. About 25 parts by mass is more preferable, and about 7 to 20 parts by mass is further preferable. Further, for example, with respect to 1 part by mass of the surfactant,
Further, the content ratio of the polyhydric alcohol and the surfactant in the O / D type emulsified oral composition is preferably about 1 to 40 parts by mass with respect to 1 part by mass of the surfactant. About 2 to 20 is more preferable, and about 3 to 15 is even more preferable.

The content ratio of the hydrocarbon oil and the polyhydric alcohol in the O / D type emulsified oral composition is, for example, about 0.5 to 5 parts by mass of the hydrocarbon oil with respect to 1 part by mass of the polyhydric alcohol. It is preferably about 0.7 to 4, more preferably about 1 to 2, and even more preferably about 1 to 2.

The content ratio of the hydrocarbon oil and the surfactant, the content ratio of the polyhydric alcohol and the surfactant, and the content ratio of the hydrocarbon oil and the polyhydric alcohol in these O / D type emulsified oral compositions are O. The / D-type emulsified composition is not particularly limited as long as it is prepared, but it is preferable to satisfy any one, more preferably any two, and all three. More preferred.

The contents of the hydrocarbon oil, the polyhydric alcohol, and the surfactant in these O / D type emulsified oral compositions are not particularly limited as long as the O / D type emulsified composition is prepared. The hydrocarbon oil is preferably about 40 to 80% by mass, more preferably about 45 to 75% by mass, and even more preferably about 50 to 75% by mass. The polyhydric alcohol is preferably about 1 to 55% by mass, more preferably about 5 to 45% by mass, and even more preferably about 10 to 40% by mass. The surfactant is preferably about 1 to 10% by mass, more preferably about 2 to 8% by mass, and even more preferably about 3 to 7% by mass.

The O / D type emulsified oral composition is preferably as stable as possible. For example, those that do not cause phase separation when allowed to stand at room temperature (25 ° C.) for 1 week after preparation are preferable.

As a method for preparing the O / D type emulsified oral composition, for example, the polyhydric alcohol and the surfactant are first stirred and mixed, and then the hydrocarbon oil is gradually added to the mixture and mixed while continuing the stirring. There is a way to do it. Mixing can be performed by a known stirrer (for example, a disper mixer or the like). If a large amount of hydrocarbon oil is added at one time, it may not be mixed uniformly or may not be viscous (phase separation occurs or remains liquid), so it is preferable to add it little by little. ..

The oral composition according to the present invention is not particularly limited, but according to a conventional method, for example, a dentifrice, a liquid dentifrice, a mouthwash (mouthwash), a gel agent, an ointment-like preparation, a pasta agent, a gum agent. It can be made into a normal dosage form such as.

As long as the effects of the present invention are not impaired, the O / D type emulsified oral composition may contain known components that can be contained in the oral composition. However, it is not preferable when the O / D type emulsified oral composition cannot be prepared by including such a component. The O / D type emulsified oral composition to which such a component is added shall be prepared, for example, by a method in which the polyhydric alcohol and the surfactant are first stirred and mixed, and the component is added and mixed together. Can be done.

Examples of such known components include abrasives, wetting agents, fragrances, activators, sweeteners, preservatives, colorants, pH adjusters, stabilizers, flavoring agents, astringents, thickeners, and the like. Examples include the medicinal properties of. In addition, such a known component can be used individually by 1 type or in combination of 2 or more types.

As an abrasive, calcium dibasic phosphate / dihydrate and anhydride, calcium phosphate, calcium phosphate tribasic, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silicic acid anhydride, silica gel, aluminum silicate, insoluble sodium metaphosphate , Tertiary magnesium phosphate, magnesium carbonate, calcium sulfate, polymethyl methacrylate, bentonite, zirconium silicate, hydroxyapatite, synthetic resin and the like can be used.

The polyhydric alcohol can also act as a wetting agent, but other wetting agents include, for example, ethanol and the like.

Fragrances include, for example, menthol, anetol, carboxylic, eugenol, limonene, peppermint oil, spearmint oil, winter green, methyl salicylate, sionale, timol, chopstick oil, eucalyptus oil, rosemary oil, sage oil, lemon oil, orange oil. , Osimen oil, citronellol, methyleugenol and the like.

Sweeteners include, for example, sodium saccharin, acesulfarm potassium, stebioside, neohesperidyldihydrochalcone, glycyrrhizin, perillartine, taumatin, aspalathylphenylalanylmethyl ester, α-methoxycinnamic aldehyde, xylite, sucralose, palatinose, stevia. Examples include fins.

Examples of the preservative include parabens such as methylparaben, ethylparaben, propylparaben and butylparaben, sodium benzoate, phenoxyethanol, alkyldiaminoethylglycine hydrochloride and the like.

Examples of the colorant include legal pigments such as Blue No. 1, Yellow No. 4, Red No. 202, and Green No. 3, mineral pigments such as ultramarine blue, enhanced ultramarine blue, and dark blue, titanium oxide, and the like.

Examples of the pH adjuster include citric acid, phosphoric acid, malic acid, pyrophosphate, lactic acid, tartaric acid, glycerophosphate, acetic acid, nitric acid, chemically possible salts thereof, sodium hydroxide and the like.

Examples of the stabilizer include sodium edetate, sodium thiosulfate, sodium sulfite, sodium chloride, calcium lactate, lanolin, triacetin, castor oil, magnesium sulfate and the like.

Examples of the flavoring agent include tea extract, tea dry distillate, propolis extract, monosodium glutamate and the like.

Examples of the astringent include baking soda, aluminum lactate and the like.

Examples of the thickener include cellulose derivatives such as hydroxypropyl cellulose, hydroxypropyl methyl cellulose and hydroxymethyl ethyl cellulose, gums such as xanthan gum, locust bin gum, carrageenan, tragacanth gum, karaya gum, arabic gum and gellan gum, polyvinyl alcohol and polyacrylic acid. Synthetic binders such as sodium, carboxyvinyl polymer, polyvinylpyrrolidone, inorganic binders such as thickening silica, aluminum silica gel, bee gum, sodium alginate, pectin, agar, gelatin, soybean polysaccharide, sodium chondroitin sulfate, sodium hyaluronate. And so on.

Other medicinal agents include fluorine compounds such as sodium fluoride, sodium monofluorophosphate, stannous fluoride; enzymes such as dextranase, mutanase, amylase, protease, lytic enzyme (lytecenzyme); tranexamic acid, ε-Aminocaproic acid, aluminum chlorohydroxyalantin, allantin, dihydrocholesterol, glycyrrhizinic acid, glycyrrhetinic acid, bisabolol, isopropylmethylphenol, glycerophosphate, chlorophyll, copper gluconate, sodium chloride, water-soluble inorganic phosphate compound, chlorhexidine salts, triclosan , Cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride; vitamins such as acetic acid-dl-α-tocopherol, pyridoxin acetate, ascorbic acid or salts thereof; aloe, ginkgo biloba, agarix, oolong tea, chamomile, karin, gymnema, kumazasa , Jincha, Tochucha, Dokudami, Hatomugi, Megusurinoki, Yomogi, Green tea, Louis Boss, Lemon balm, Rosemary, Clubmin, Lacanca, Perilla, Cranberry, Nokogirisou, Elder, Ricolis, Hakka, Eucalyptus, Galana, Kanzo, Bodaiju, Hop Examples thereof include plant extracts such as cacao, mulberry leaves, thyme, and ascorbic acid.

The blending amount of these known components should be such that it is blended in a normal oral composition within a range that does not interfere with the effect of the present invention (particularly, does not interfere with the preparation of the O / D type composition). It can be adjusted as appropriate for reference.

The present invention also includes an O / D type emulsified composition containing a hydrocarbon oil, a polyhydric alcohol, and a surfactant, which are carriers for an oral composition. The composition of the O / D type emulsified composition is basically the O / D type emulsified composition used in the above O / D type emulsified oral composition, except that the use is a carrier for the oral composition. Similar to the composition.

A suitable O / D type emulsified oral composition can be produced by further adding a component permitted for the oral composition (for example, the above-mentioned known component) to the carrier for the oral composition.

In addition, in this specification, "including" also includes "consisting essentially" and "consisting of" (The term "comprising" includes "consisting essentially of" and "consisting of.").

Hereinafter, the present invention will be described in more detail, but the present invention is not limited to the following examples. Unless otherwise specified, "%" indicates "mass%".

Preparation of O / D type emulsified composition 1
Using the components shown in Table 1, each component is mixed so as to have 35% polyhydric alcohol, 5% surfactant, and 60% hydrocarbon oil to prepare an O / D type emulsified composition of each example. did. As the polyglycerin fatty acid ester, a product of Taiyo Kagaku Co., Ltd. (Sunsoft series) was obtained and used. In addition, glycerin was used as the polyhydric alcohol in all the examples.

Mixing was performed in more detail as follows. A polyhydric alcohol and a surfactant were added to a container (beaker) and stirred with a disper mixer to mix them. Hydrocarbon oil was further added little by little while stirring was continued. When the hydrocarbon oil was added, the mixture was heated as needed.

After the preparation, the obtained composition was visually observed to confirm that phase separation did not occur in any of them. From this, it was found that the O / D type emulsified composition was prepared. Further, when these compositions were contained in the mouth, no burning sensation derived from glycerin was particularly felt, and there was no problem in usability.

Preparation of O / D type emulsified composition 2
An O / D type emulsified composition was prepared in the same manner as above, except that polyglyceryl laurate-5 having an HLB of 10.9 or polyglyceryl-10 laurate having an HLB of 15.7 was used as the surfactant. (Example α and Example β, respectively). When polyglyceryl-10 laurate having an HLB of 15.7 was used (Example β), biphasic separation was not observed as in the compositions of Examples 1 to 8, but the HLB was 10.9. Two-phase separation was observed when polyglyceryl-5 laurate (Example α) was used. Therefore, it was suggested that the stability of the obtained composition is better when the HLB of the surfactant used is relatively high (for example, 11 or more).

Preparation of O / D type emulsified composition 3
In Example 6, an O / D type emulsified composition was prepared using a sorbitol solution (70% aqueous solution of sorbitol) instead of glycerin (Reference Example 1: 6% water is contained in the composition). Two-phase separation did not occur in the composition.

Preparation of O / D type emulsified composition 4
Using the compositions shown in Table 2, the O / D type emulsified compositions of Examples A to E were prepared in the same manner as described above. The numerical values in the table indicate the content (mass%) of each component. The PEG-60 hydrogenated castor oil used was HLB 14.0. Regarding the obtained composition, the applicability to a toothbrush and the stability after 1 week of preparation (whether the phase separation can be visually confirmed) were examined. The results are also shown in Table 2. The evaluation criteria for applicability to toothbrushes are as follows.
○: The drug does not drip from the toothbrush and has shape retention △: The drug is likely to drip from the toothbrush and does not have much shape retention ×: The drug drips from the toothbrush, so it is inappropriate

In the examination of stability, it was visually confirmed whether or not phase separation occurred when the mixture was allowed to stand at room temperature (25 ° C.) for 1 week after preparation.

Claims (9)

Contains 50-80% by mass of hydrocarbon oil , 10-40% by mass of polyhydric alcohol, and 2-8% by mass of surfactant with HLB13 or higher , and 0% by mass to 0.5% by mass of water. O / D type emulsion oral composition is (excluding O / D type emulsion oral composition comprising polyethylene). The O / D type emulsified oral composition according to claim 1, wherein the water content is more than 0% by mass and 0.4% by mass or less. The O / D type emulsified oral composition according to claim 1 or 2 , which is not phase-separated by standing at 25 ° C. for 1 week after preparation. The O / D type emulsified oral composition according to any one of claims 1 to 3 , wherein the polyhydric alcohol is at least one polyhydric alcohol selected from the group consisting of a divalent alcohol and a trihydric alcohol. Stuff. The O / D type emulsified oral composition according to any one of claims 1 to 4 , wherein the hydrocarbon oil is at least one hydrocarbon oil selected from the group consisting of squalane and paraffin. Surface active agents are polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid glyceryl, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene hydrogenated castor oil, The O / D type emulsified oral composition according to any one of claims 1 to 5 , which is at least one selected from the group consisting of polyoxyethylene sterol and polyoxyethylene sterol. The hydrocarbon oil is at least one selected from the group consisting of squalane and paraffin.
The polyhydric alcohol is at least one selected from the group consisting of glycerin and propylene glycol.
The surfactant is at least one selected from the group consisting of polyglycerin fatty acid ester and polyoxyethylene hydrogenated castor oil.
The O / D type emulsified oral composition according to any one of claims 1 to 6. The O / D type emulsified oral composition according to any one of claims 1 to 7, wherein the surfactant is an HLB 14 or higher surfactant. O / D type emulsification containing 50 to 80% by mass of hydrocarbon oil, 10 to 40% by mass of polyhydric alcohol, and 2 to 8% by mass of a surfactant having an HLB of 13 or more, which is a carrier for an oral composition. Composition (excluding O / D type emulsified composition containing polyethylene) .