JP2014051444A - Two layer separation type liquid composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a two layer separation type liquid composition for an oral cavity which has a taste free of a disagreeable taste, provides a sense of mildness in the oral cavity, and provides a tempostabile visual appearance by being clearly separated into two layers when still standing.SOLUTION: A two layer separation type liquid composition for an oral cavity has two separated layers comprising: a W/O type emulsion composition layer including an oil solution (A) which is a liquid at 25°C and a polyoxyethylene alkyl ether (B); and a water layer. The water layer includes a hydroxyalkyl cellulose (C).

Description

  The present invention has no taste when used, gives a mild feeling in the oral cavity, gives a stable appearance over time by separating cleanly into two layers upon standing, and is particularly suitable as a mouthwash The present invention relates to a liquid oral composition.

Conventionally, it is a two-layer formulation that consists of an oil layer and a water layer containing water, and has a beautiful appearance and enjoyment. The liquid composition is separated into two layers when allowed to stand and is used by shaking. Is known, and Patent Document 1 (Japanese Patent Laid-Open No. 11-79962) proposes a two-phase liquid composition for oral cavity.
However, when a two-layered oral composition composed of an oil layer and an aqueous layer is applied to the oral cavity, there is an unpleasant taste due to the oil during use, and there is a problem in palatability.

  In addition, the oil layer and the water layer of the two-layer liquid composition are usually transparent, and it is difficult to recognize that they are separated into two layers when left standing and separated. There is a problem that it is likely to occur).

JP-A-11-79962

  The present invention has been made in view of the above circumstances, has a two-layer separation that gives a mild appearance to the oral cavity without any taste at the time of use, and provides a stable appearance over time by separating cleanly into two layers upon standing. An object of the present invention is to provide a type liquid oral composition.

  As a result of intensive studies to achieve the above object, the present inventors have found that the oil layer of the two-layer separated type liquid oral composition comprising an oil layer containing an oil agent and a water layer containing water is a liquid at 25 ° C. By containing a certain oil agent (A) and polyoxyethylene alkyl ether (B), in particular, polyoxyethylene alkyl ether having an average addition mole number of ethylene oxide of 2 to 12 moles and an alkyl group having 12 to 22 carbon atoms, An oil layer is emulsified to form a W / O emulsion composition, and the liquid oral composition obtained by separating the emulsion composition layer and the aqueous layer into two layers has no bad taste when used, and the oral cavity It has been found that a mild feeling is imparted to the film, and that it has an excellent appearance with respect to stability over time that can be visually discriminated that the two layers are clearly separated upon standing.

In the two-layer-separated liquid oral composition of the present invention, the emulsion composition layer and the aqueous layer in which the oil agent (A) is emulsified with the polyoxyethylene alkyl ether (B) to form a W / O emulsion are two. By separating the layers, it is surprisingly possible to reduce the unpleasant taste derived from the oil during use and to give a mild feeling to the oral cavity. In addition, the upper W / O emulsion composition layer separated into two layers is neatly turbid and has an appearance different from that of the lower transparent water layer, in particular, a uniform white turbid appearance, and this appearance is stably maintained over time. It can be clearly discerned visually that the layers are separated. Furthermore, since the layer containing the oil agent is a W / O type emulsion composition layer, residual oil stains are eliminated when the two-layer separated composition is used on a washstand or the like, and the usability is also improved.
Such a reduction in taste, imparting a mild feeling, improving the appearance of the preparation, and further improving the usability can be achieved by the combined use of component (A) and component (B). These surfactants, for example, oil-soluble polyoxyethylene hydrogenated castor oil, cannot be used in combination, and are particularly remarkable.

  In addition, the applicant has separated two layers of an oil layer containing an oil agent that is liquid at 25 ° C. and an aqueous layer containing condensed phosphoric acid or a salt thereof into PCT / JP2012 / 55617, A two-layer separation type liquid oral composition that has a high effect of removing dirt from the teeth and has reduced oily feeling and astringent feeling because the content of the oil agent and the ratio of the oil agent to condensed phosphoric acid or a salt thereof are in an appropriate range. However, this is a reduction in the oily feeling of the oil agent due to the condensed phosphoric acid or a salt thereof, and a reduction in the astringent feeling of the condensed phosphoric acid or a salt thereof due to the oil agent. It is technically different from reducing taste and imparting a mild feeling.

  Therefore, in the present invention, two layers of the W / O type emulsion composition layer containing the oil agent (A) and polyoxyethylene alkyl ether (B) which are liquid at 25 ° C. and the aqueous layer are separated. Provided are the two-layer separated liquid oral composition, and the aqueous layer further contains a hydroxyalkyl cellulose (C).

  According to the present invention, there is provided a two-layer separated type liquid oral composition which has no taste when used, gives a mild feeling in the oral cavity, and cleanly separates into two layers upon standing to give a stable appearance over time. Can be provided.

  The present invention will be described in further detail below. The two-layer separation type liquid oral composition of the present invention is a W / O type (water-in-oil type) emulsified composition layer containing an oil agent (A) and a polyoxyethylene alkyl ether (B) which are liquid at 25 ° C. And the two layers of the water layer are separated. Here, the two-layer separation type is separated into two layers of an aqueous layer and an emulsified composition layer at the time of standing, and when lightly shaken at the time of use, the two layers are easily mixed to become an emulsion, and then left to stand. Then, the preparation returns to the original two layers.

  More specifically, here, the two-layer separation type preparation has an appearance that separates into two layers of an aqueous layer and an emulsified composition layer when left standing, and when used, the two layers are separated by shaking lightly. Easily mix and become milky, and after use, leave it shaken and leave it to separate into two layers. In this case, stop shaking the product and let it stand and separate into two layers within one hour at the latest It is only necessary to return to the original state. Furthermore, when the preparation is used after shaking, the two-layer separation state of the emulsified composition layer and the aqueous layer is stabilized and maintained when the container is left standing without shaking or stirring. If it is shaken again later, it will be mixed again, so that it can be used as an emulsion when used.

  Here, separating into two layers is as follows. When 60 mL of the composition is put into an Epton tube having a capacity of 100 mL and shaken up and down at a speed of 3 times per second for 5 seconds, and then left to stand after shaking, the composition may be composed of two layers. It can be recognized in appearance.

  The oil agent (A) contained in the emulsified composition layer is an oil agent that is liquid at 25 ° C., and is a component that characterizes the appearance of the product as a preparation that separates into two layers. Here, being liquid at 25 ° C. means a material having a viscosity of 100 mPa · s or less when the viscosity is measured using a BL type viscometer in an environment of 25 ° C.

  Examples of the oil agent (A) include hydrocarbons, fatty acid esters of glycerin, fatty acid esters of alcohol, and silicones. Specifically, medium chain fatty acid triglycerides such as tri (caprylic acid / capric acid) glyceryl composed of fatty acids having 6 to 12 carbon atoms contained in liquid paraffin, coconut oil, palm kernel oil, milk, breast milk, jojoba oil, Examples include isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, octyldodecyl palmitate, decyl oleate, dimethylpolysiloxane represented by the following formula (1), methylpolysiloxane, and the like, and one or more of these Is used. Among these, liquid paraffin, medium chain fatty acid triglyceride, and isopropyl myristate are more preferable.

（式中、ｍは１〜１０，０００の整数である。）

(In the formula, m is an integer of 1 to 10,000.)

  The blending amount of the component (A) is preferably 15 to 60% (mass%, the same applies hereinafter) of the whole composition, and more preferably 20 to 40%. A blending amount of 15% or more is preferable for giving a mild feeling, and a mixing ratio of 60% or less is preferable because it gives a stable emulsion composition layer and the taste during use does not become a problem.

The component (B) polyoxyethylene (hereinafter abbreviated as POE) alkyl ether may be any as long as it can form a W / O emulsion.
The POE alkyl ether of component (B) is preferably an average addition mole number of ethylene oxide of 2 to 12 moles, particularly 3 to 8 moles, especially 5 or 7 moles, and an alkyl group having 12 to 22 carbon atoms. In particular 12 to 14 POE alkyl ethers. It is preferable that the average added mole number of ethylene oxide and the carbon number of the alkyl group are in the above ranges since the W / O emulsion composition layer is more stable.

The HLB value of the POE alkyl ether is not particularly limited, but an appropriate HLB value is preferable because the W / O emulsion can be further stabilized. Specifically, POE alkyl ether having an HLB value of 5 to 13, particularly 6 to 12, particularly 8 to 11 is more preferable.
“HLB” defined in the present invention is based on an organic conceptual diagram, and classifies surfactants into hydrophilic groups (inorganic groups) and hydrophobic groups (organic groups), and the index values thereof are represented by the following formula ( The value calculated by I). For the index value, use “Progress and application development of functional emulsifier and emulsification technology” (Publisher: Kentaro Shima, publisher: CMC Co., Ltd., published on 22nd May 1998) did.
HLB = (Σ (inorganic value) / Σ (organic value)) × 10 (I)

  In addition, even if the oil agent (A) is emulsified with a surfactant other than the POE alkyl ether, it becomes unstable and non-uniform over time, the appearance is impaired, and the taste is reduced to give a mild feeling. I can't. Even if the HLB value is in the above range, the surfactants other than the POE alkyl ether do not have the effect of the present invention.

  Specific examples of such POE alkyl ethers include POE lauryl ether, POE stearyl ether, POE cetyl ether, POE oleyl ether, and POE behenyl ether, in which the average addition mole number of ethylene oxide is in the above range. One or more of them can be used. Among these, POE lauryl ether and POE cetyl ether are preferable because they are excellent in taste.

Component (B) is preferably added to the oil agent (A) in an amount of 0.2 to 4%, more preferably 0.6 to 2%. It is preferable to add 0.2% or more because the emulsified composition layer is stabilized, the taste does not become a problem, and a mild feeling is obtained. If it is 4% or less, it is preferable because the taste caused by the fatty acid of the surfactant does not become a problem.
In addition, the compounding quantity of a component (B) is 0.03-2.4% with respect to the whole composition, More preferably, it is 0.12-0.8%. When the blending amount is within this range, the emulsion composition layer can be stabilized, the taste can be reduced, and the effect of imparting a mild feeling can be improved.

  In the present invention, in addition to the components (A) and (B), other known oil-soluble components can be blended in the oil layer as necessary as long as the effects of the present invention are not hindered. For example, a fragrance | flavor, a pigment | dye, an active ingredient, etc. are mentioned.

  As the fragrance, known oil-soluble fragrances that can be used in the composition for oral cavity can be added within a range that does not interfere with the effects of the present invention. Particularly, the fragrances include menthol (D), thymol (E-1), and carvacrol ( It is preferable to combine and combine one or more selected from E-2) and one or more components (F) selected from rose, lavender, chamomile, jasmine, oris and violet. When using one or more selected from the above component (D), component (E-1) and component (E-2) and component (F) in combination with the oil agent (A), oil in use Can improve the feeling of irritation, improve stickiness in the oral cavity after use, and improve palatability.

As the menthol of component (D), in addition to synthetic menthol and natural menthol, menthol-containing essential oils such as peppermint oil and peppermint oil may be used. Synthetic menthol is good in terms of improving stickiness after use. For example, those manufactured by Takasago International Corporation can be used.
The amount of component (D) menthol is preferably 0 to 0.2% of the total composition, more preferably 0.005 to 0.2%, and still more preferably 0.01 to 0.1%. The stickiness can be improved as the blending amount increases, but it is preferably 0.2% or less because the feeling of irritation does not become a problem.
Moreover, when mix | blending a component (D), (D) / (A) is preferably 0.0001-0.006 as a mass ratio with respect to a component (A), More preferably, it is 0.0003-0.004. It mixes in the ratio which becomes. A ratio of 0.0001 or more is suitable for improving stickiness and irritation, and a ratio of 0.006 or less is preferable because irritation does not cause a problem.

Component (E) is thymol (E-1) and / or carvacrol (E-2), and either thymol (E-1) or carvacrol (E-2) may be blended alone, Or you may mix | blend combining 2 types.
Component (E) thymol and carvacrol include synthetic products, natural isolated products, and essential oils containing thymol and / or carvacrol, such as thyme oil, oregano oil, origanum oil, ajowan oil, marjoram oil, etc. It may be used.
The amount of component (E) (thymol (E-1) and / or carvacrol (E-2)) is preferably 0 to 0.02%, more preferably 0.001 to 0.02 of the total composition. %, More preferably 0.002 to 0.01%. The stickiness can be improved as the blending amount increases, but it is preferably 0.02% or less because the feeling of irritation does not become a problem.
Moreover, when mix | blending a component (E), (E) / (A) is preferably 0.00003-0.0006 as a mass ratio with respect to a component (A), More preferably, it is 0.00006-0.0004. It mixes in the ratio which becomes. It is suitable for improvement of stickiness and irritation to be 0.00003 or more, and is preferably 0.0006 or less because irritation does not cause a problem.
In addition, a component (D), a component (E-1), and a component (E-2) may mix | blend any or a component (D) and a component (E-1) and / or in the point of an effect expression. You may use a component (E-2) together.

Ingredient (F) is one or more fragrance ingredients selected from rose, lavender, chamomile, jasmine, oris, and violet. Among them, rose, lavender, chamomile, and jasmine are particularly preferable for suppressing irritation. .
The fragrance component of component (F) is obtained by steam distillation or solvent extraction of all or a part (flowers, leaves, stems, roots, etc.) of rose, lavender, chamomile, jasmine, oris or violet plants. It is generally called oil, absolute, concrete, etc. Specific examples of the fragrance component used as the component (F) include rose oil, rose absolute, lavender oil, lavender absolute, chamomile oil, jasmine absolute, oris oil, oris concrete, violet absolute, and the like.

  The amount of component (F) is preferably 0.0002 to 0.1%, more preferably 0.002 to 0.05% of the entire composition. Although the irritation feeling can be improved as the blending amount is increased, it is preferably 0.1% or less because irritation does not become a problem.

  Component (F) is blended in such a ratio that (F) / (A) is preferably 0.00001 to 0.005, more preferably 0.00006 to 0.002 as a mass ratio with respect to component (A). . It is suitable for improvement of stickiness and irritation to be 0.00001 or more, and is preferably 0.005 or less because irritation does not cause a problem.

  Examples of the dye include oil-soluble dyes such as Red No. 215, Red No. 225, Yellow No. 201, and Yellow No. 204. Examples of the active ingredient include isopropylmethylphenol, triclosan, tocopherol acetate and the like. The blending amount of these optional components can be a normal amount as long as the effects of the present invention are not hindered.

In the two-layer separated type liquid oral composition of the present invention, it is preferable to further mix hydroxyalkyl cellulose (C) in the aqueous layer, and by mixing hydroxyalkyl cellulose as component (C), the emulsion composition layer Can be stabilized more.
Component (C) is preferably an alkyl group having 2 to 4 carbon atoms such as hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, etc., especially hydroxyethylcellulose, since the stability of the emulsion composition layer is further increased. preferable.

  When mix | blending a component (C), the compounding quantity has preferable 0.01 to 0.5% of the whole composition, More preferably, it is 0.05 to 0.3%. When 0.01% or more is blended, the emulsion composition layer can be further stabilized, and the taste does not become a problem and a mild feeling can be obtained. The blending amount is preferably 0.5% or less because the taste does not become a problem.

  In the present invention, the water layer may further contain a known water-soluble component other than the component (C) as necessary within a range not impeding the effects of the present invention. For example, wetting agents, thickeners, sweeteners, pigments, pH adjusters, preservatives, water-soluble fragrances, active ingredients and the like can be mentioned. It is preferable not to add a surfactant other than the component (B), not limited to the water layer and the oil layer, because the emulsion layer is stabilized and the appearance of the formulation in which the two layers are separated more beautifully is obtained.

  Specific examples of the wetting agent include sugar alcohols such as sorbit, xylit, maltitol, and erythritol, and polyhydric alcohols such as glycerin, propylene glycol, polyethylene glycol, hexylene glycol, and butylene glycol.

  Examples of the thickener include carboxymethylcellulose sodium, methylcellulose, polyethylene glycol, xanthan gum, carrageenan, guar gum, sodium alginate, propylene glycol alginate, agar, sodium polyacrylate, polyvinyl alcohol, polyvinyl pyrrolidone, gellan gum, pectin and the like.

  As sweeteners, sodium saccharin, aspartame, stevia extract, etc., and as pigments, Red No. 2, Red No. 3, Red No. 102, Red No. 106, Yellow No. 4, Yellow No. 5, Orange No. 205, Blue No. 1, Green No. 3 Examples of water-soluble dyes and preservatives such as paraoxybenzoic acid esters such as methylparaben, sodium benzoate, and the like.

  As active ingredients, fluorides such as sodium fluoride, sodium monofluorophosphate, tin fluoride, enzymes such as epsilon aminocaproic acid, dextranase, mutanase, tranexamic acid, allantochlorohydroxyaluminum, hinokitiol, lauroyl sarcosine sodium, Ascorbic acid, dihydrocholesterol, α-bisabolol, chlorhexidine salts, azulene, dipotassium glycyrrhizinate, copper chlorophyllin sodium, chlorophyll, copper gluconate and other copper compounds, aluminum lactate, strontium chloride, potassium nitrate, berberine, zinc citrate, buckwheat extract, Examples include chamomile, clove, rosemary, ougon, safflower extracts. These optional components can be blended in a usual amount as long as the effects of the present invention are not hindered.

The solvent is usually water, but a lower monohydric alcohol such as ethanol may be further blended within a range that does not hinder the effects of the present invention.
Moreover, it is preferable that the liquid oral cavity composition of this invention adjusts pH in 25 degreeC to 6.5-8.5.

  The ratio of the aqueous layer to the emulsified composition layer (aqueous layer / emulsified composition layer) in the two-layer separated type liquid oral composition is preferably 0.6 to 9, more preferably 0.6 to 6 in terms of mass ratio. More preferably, it is 1-5. It is preferable that it is 0.6 or more from the point that a mild feeling is easily felt in the oral cavity, and it is preferable that it is 9 or less from the point that it becomes difficult to feel the taste.

  The two-layer separated liquid oral composition of the present invention can be prepared by mixing the component (A) and the component (B) with water, specifically, if necessary, dissolves a water-soluble component in water, Further, the POE alkyl ether (B) and, if necessary, other oil-soluble components can be dissolved in the oil agent (A), and these can be mixed to prepare. In this case, the emulsified composition layer partially takes in water to form a W / O type emulsion, and most of the POE alkyl ether (B) is contained in the emulsified composition layer. Exists.

  The liquid oral composition of the present invention is separated into two layers of an aqueous layer and an emulsified composition layer when left standing, but the two layers easily mix and become an emulsion by shaking lightly during use. In this state, it can be applied to the oral cavity, and it is preferably applied by rinsing the mouth.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
Two-layer separated liquid oral compositions having the compositions shown in Tables 1 to 5 were prepared by the following method. The following evaluation was performed about the obtained 2 layer separation type liquid oral cavity composition. The results are shown in the table.

<Method for Preparing Two-layer Separable Liquid Oral Composition>
Dissolve water-soluble components (sodium saccharin, glycerin, etc.) in water, dissolve oil-soluble components (polyoxyethylene alkyl ether (B), fragrance, methyl paraben, etc.) and surfactant in oil agent (A), Prepared by mixing in ratio. The composition of the comparative example was prepared according to the above.

<Evaluation method>
(1) Evaluation of appearance (upper layer) after storage The composition shown in the table is lightly shaken at the time of use so that the two layers are mixed, and 50 mL of this composition is made into a cylindrical container (diameter 40 mm x height 120 mm) made of PET. And shaken 20 times in 10 seconds. Then, after leaving still at 50 degreeC, the external appearance of the emulsion composition layer of the upper layer from the side surface was observed one month afterward, and evaluated by the following five steps, and it showed in the table | surface by *, (double-circle), (circle), (triangle | delta), and x.
Judgment criteria ☆: The emulsion composition layer is cloudy, uniform and stable ◎: The emulsion composition layer is cloudy, almost uniform and stable ○: The emulsion composition layer is cloudy, but slightly Appearance is good even though it is non-uniform and partly transparent. Δ: The emulsion composition layer is cloudy, but is slightly non-uniform and contains both transparent and opaque parts. X: Emulsion composition The layer is cloudy, but it is uneven and the entire surface is uneven or transparent

(2) Evaluation of unpleasant taste The composition shown in the table was lightly shaken at the time of use, and the two layers were mixed together. After 20 ml of this composition was gently shaken up and down about 10 times, immediately contained in the mouth, 30 The unpleasant taste during mouth-washing was evaluated in the following 5 levels, and the average score of 10 people was shown in the table with ☆, ◎, ○, Δ, × according to the following criteria.
Judgment criteria 5: No unpleasant taste was observed 4: Almost no unpleasant taste was recognized 3: Slight unpleasant taste was recognized 2: No unpleasant taste was recognized 1: Strong unpleasant taste was recognized Evaluation standard ☆: Average point 4.5 points or more ◎: Average point 4.0 points or more and less than 4.5 points ○: Average point 3.0 points or more and less than 4.0 points △: Average point 2.0 points or more and 3.0 points Less than ×: Average score of 1.0 or more and less than 2.0

(3) Evaluation of mild feeling The composition shown in the table was lightly shaken at the time of use, and the two layers were mixed, and 20 mL of this composition was gently shaken up and down about 10 times, then included in the mouth and rinsed for 30 seconds. The mild feeling of time was evaluated in the following five stages, and the average score of 10 people was shown in the table with ☆, ◎, ○, Δ, × according to the following criteria.
Judgment criteria 5: Very mild feeling was recognized 4: Very mild feeling was recognized 3: Slightly mild feeling was recognized 2: Almost mild feeling was not recognized 1: No mild feeling was recognized Evaluation Standard ☆: Average point 4.5 points or more ◎: Average point 4.0 points or more and less than 4.5 points ○: Average point 3.0 points or more and less than 4.0 points △: Average point 2.0 points or more 3.0 Less than point x: Average score of 1.0 point or more and less than 2.0 point

Details of the raw materials used are shown below. POE is an abbreviation for polyoxyethylene, and the numerical value in parentheses after POE is the average added mole number.
Liquid paraffin: manufactured by Sanko Chemical Co., Ltd., liquid paraffin No. 70S
Tri (caprylic acid / capric acid) glyceryl: NOF Corporation, Panacet 810
Isopropyl myristate: NOF Corporation, IPM-R
Isopropyl palmitate: NOF Corporation, IPP-R
Polyoxyethylene hydrogenated castor oil 20: HLB9, POE (5) manufactured by Nippon Emulsion Co., Ltd. (5) Lauryl ether: HLB10, POE manufactured by Nihon Emulsion Co., Ltd. (7) Cetyl ether: HLB10, POE manufactured by Nihon Emulsion Co., Ltd. (6) Stearyl ether: HLB8, POE (8) Oleyl ether: HLB10 manufactured by Nippon Emulsion Co., Ltd. POE (5) Behenyl ether: HLB7 manufactured by Nippon Emulsion Co., Ltd. POE (12) Cetyl ether: HLB12 manufactured by Nippon Emulsion Co., Ltd. POE (12) lauryl ether manufactured by Nippon Emulsion Co., Ltd .: HLB13, Pluronic L64 manufactured by Nippon Emulsion Co., Ltd., polyoxyethylene (25) polyoxypropylene glycol (30), HLB10, hydroxyethyl cellulose manufactured by Asahi Denka Kogyo Co., Ltd. : Daicel FineChem (Ltd.), SE400
Hydroxypropyl methylcellulose: Shin-Etsu Chemical Co., Ltd., HPMC50
In the table, perfume A and perfume B have the following compositions, and details of the blended perfume are shown below.
Fragrance A: Fragrance fragrance B containing no menthol, thymol, carvacrol, rose absolute, lavender oil, chamomile oil, jasmine absolute, oris concrete and violet absolute B: menthol 0.05%, thymol 0.005%, carvacrol 0. Fragment menthol containing 0.001% and 0.001% each of Rose Absolute, Lavender Oil, Chamomile Oil, Jasmine Absolute, Oris Concrete and Violet Absolute: Made by Takasago Inc., Mentor JP
Thymol: Takasago International Corporation Carvacrol: Takasago International Corporation Rose Absolute: Hasegawa Inc. Lavender Oil: Takasago International Inc. Chamomile Oil: Ve Manfis Inc. Jasmine Absolute: Ve Manfis Fragrance Co., Ltd. Oris Concrete: Hasegawa Fragrance Co., Ltd. Violet Absolute: Hasegawa Fragrance Co., Ltd.

Claims (7)

  A W / O type emulsion composition layer containing an oil agent (A) and a polyoxyethylene alkyl ether (B), which are liquid at 25 ° C., and an aqueous layer are separated from each other. Two-layer separated liquid oral composition.   2. The polyoxyethylene alkyl ether of component (B) is one having an average addition mole number of ethylene oxide of 2 to 12 moles and an alkyl group having 12 to 22 carbon atoms. A two-layer separated liquid oral composition.   The polyoxyethylene alkyl ether of component (B) is one having an average addition mole number of ethylene oxide of 5 or 7, and an alkyl group having 12 to 14 carbon atoms. Layer separated liquid oral composition.   The two-layer separated liquid oral composition according to claim 1, 2 or 3, wherein the component (B) is blended in an amount of 0.2 to 4% by mass with respect to the oil agent (A).   5. The two-layer separated liquid oral composition according to claim 1, wherein the oil agent (A) is one or more selected from liquid paraffin, medium chain fatty acid triglyceride and isopropyl myristate.   The two-layer separated liquid oral composition according to any one of claims 1 to 5, wherein the aqueous layer further contains a hydroxyalkyl cellulose (C).   The two-layer separated liquid oral composition according to claim 6, wherein the hydroxyalkyl cellulose as the component (C) is hydroxyethyl cellulose.