WO2023234379A1

WO2023234379A1 - Oral composition

Info

Publication number: WO2023234379A1
Application number: PCT/JP2023/020395
Authority: WO
Inventors: 拓井手上; 勉高塚
Original assignee: プレミアアンチエイジング株式会社
Priority date: 2022-06-03
Filing date: 2023-06-01
Publication date: 2023-12-07
Also published as: TW202406531A

Abstract

The present invention provides an oral composition by means of which plaque (dental plaque), staining (coloring), protein stains, bad breath, tartar, etc. can be effectively removed. The present invention relates to an oral composition containing: (A) 30-95 mass% of a liquid oil component; and (B) one or more nonionic surfactants.

Description

Oral composition

The present invention relates to oral compositions and the like, and more particularly to oral compositions containing liquid oil.

In the oral cavity, various oral problems occur due to food and drink coming into contact with tooth surfaces and remaining there. Food residue causes plaque to form on tooth surfaces through the metabolism of oral bacteria, promoting the development and progression of oral diseases such as cavities and periodontal disease. In addition, acidic foods and drinks such as citrus fruits and soft drinks directly cause demineralization (acid erosion) when they come into contact with teeth. Furthermore, stains, which are discolored stains on teeth, are formed due to the accumulation of coloring components such as polyphenols derived from food and drink, which deteriorate the aesthetics of teeth, reduce the cleanliness around the mouth, and ultimately the overall impression of the face.

In order to prevent these oral problems, it is desirable to reduce the contact between food and drink and tooth surfaces as much as possible by coating the tooth surfaces. As techniques for coating tooth surfaces, tooth surface coating techniques using phosphate esters or polymers (Patent Documents 1 and 2), tooth reinforcement techniques using tea extracts (Patent Document 3), and the like have been proposed.

Japanese Patent Application Publication No. 5-320032 Japanese Patent Application Publication No. 2005-200345 Japanese Patent Application Publication No. 2005-29496

However, with the techniques proposed in Patent Documents 1 to 3, it is difficult to make the user feel the tooth surface coating effect satisfactorily, and there is a problem in improving the user experience. In the oral cavity, which is constantly moistened with saliva, it has been difficult for conventional water-based oral compositions such as those disclosed in Patent Documents 1 to 3 to provide the feeling of tooth surface coating when used.

As a result of extensive research, the present inventors found that an oil-based composition containing a liquid oil and a surfactant disperses the oil base in the oral cavity and coats the oral tissues, resulting in a high level of tooth surface coating. We found that this shows that

Also, due to its excellent retention on tooth surfaces, it is possible to prevent the deposition of plaque and stains by tooth surface coating, as well as to prevent the elution of calcium ions from the tooth surface. Furthermore, since the oral composition of the present invention has excellent retention properties in the oral cavity (tooth surfaces, gums, mucous membranes, tongue), it increases the amount of active ingredients contained in the composition retained in the oral cavity. be able to.

This results in an oral composition that strengthens tooth structure, sterilizes, anti-inflammatory, suppresses hypersensitivity, inhibits tartar formation, inhibits collagen decomposition, astringent action, promotes blood circulation, activates cells, produces collagen, repairs tissue, and enhances hemostasis and moisturizing effects. It becomes possible to provide.

In addition, the oral composition of the present invention has a high cleaning effect due to the high content of liquid oil and surfactant, so it is effective against plaque, stains, protein stains, bad breath, and tartar. can be removed.

The present invention includes, for example, the subject matter described in the following sections.
Item 1.
(A) 30 to 95% by mass of liquid oil,
(B) An oral composition containing one or more nonionic surfactants.
Item 2.
Item 2. The oral composition according to item 1, wherein the liquid oil is an ester compound.
Item 3.
Item 3. The oral composition according to item 1 or 2, wherein the liquid oil is a saturated fatty acid ester compound.
Item 4.
Item 4. The oral composition according to any one of Items 1 to 3, wherein the one or more nonionic surfactants have an HLB value of 5 to 13.
Item 5.
Item 5. The oral composition according to any one of Items 1 to 4, further comprising 1 to 30% by mass of solid oil having a melting point of 50 to 120°C.
Item 6.
6. The oral composition according to item 5, wherein the solid oil is a hydrocarbon.
Section 7.
Item 7. The oral composition according to any one of Items 1 to 6, further comprising (C) a refreshing agent and/or sweetener that can be applied to the oral cavity.
Section 8.
Furthermore, it contains a condensed phosphate, and the condensed phosphate is one or more selected from the group consisting of pyrophosphate, tripolyphosphate, and metaphosphate, according to any one of Items 1 to 7. Oral composition.
Section 9-1.
Furthermore, any one of Items 1 to 8 contains a lipophilic active ingredient, and the lipophilic active ingredient is one or more selected from the group consisting of isopropylmethylphenol, cetylpyridinium chloride, glycyrrhizic acids, glycyrrhetinic acid, and vitamins. Oral composition according to item 1.
Section 9-2.
Claim 1 further comprising a sterilizing/disinfecting agent, an anti-inflammatory agent, and/or vitamins, wherein the sterilizing/disinfecting agent is isopropylmethylphenol or cetylpyridinium chloride, and the anti-inflammatory agent is glycyrrhizinic acids or glycyrrhetinic acid. Oral composition according to.
Item 10.
10. The oral cavity composition according to any one of Items 1 to 9, further comprising one or more water-soluble polymers having an effect of removing coloration and/or bleaching tooth hard tissue.
Item 11.
Item 10. A method for removing tooth stains by using the oral composition according to any one of Items 1 to 9 in combination with an electric toothbrush.

The oral composition of the present invention has a high tooth surface coating feeling, and the tooth surface coating prevents the deposition of plaque and stains, suppresses decalcification, has a high cleaning effect, and furthermore, the active ingredients contained therein retain in the oral cavity. can also be increased.

Hereinafter, each embodiment included in the present invention will be described in more detail. The present invention preferably includes an oral composition, a method for producing the composition, etc., but is not limited thereto, and the present invention includes everything disclosed herein. In addition, hereinafter, "%" indicates "mass %" unless otherwise specified.

The liquid oil is not particularly limited as long as it can be applied to the oral cavity and is liquid at room temperature (25°C). For example, 2-ethylhexyl palmitate, isopropyl myristate, ethyl linoleate, isopropyl palmitate, oleyl oleate, isotridecyl myristate, 2-ethylhexyl myristate, decyl oleate, isostearyl myristate, octyl myristate. Dodecyl, 2-ethylhexyl stearate, 2-hexyldecyl stearate, isostearyl palmitate, 2-octyldodecyl oleate, isopropyl isostearate, cetyl 2-ethylhexanoate, di(caprylic/capric) propylene glycol, Propylene glycol dicaprylate, propylene glycol dicaprate, glyceryl tricaprylate, glyceryl tri-2-ethylhexanoate, glyceryl triisostearate, glyceryl tri(caprylic/capric acid), glyceryl triisopalmitate, trimethylolpropane triisostearate, Ester oils such as trimethylolpropane 2-ethylhexanoate, isononyl isononanoate, isotridecyl isononanoate, isostearyl isostearate, 2-hexyldecyl isostearate; squalane, polybutene, liquid paraffin, vaseline, low density liquid paraffin, light liquid isoparaffin , heavy liquid isoparaffin, hydrocarbon oils such as polyisobutylene; fats and oils such as jojoba oil, avocado oil, safflower oil, camellia oil, mink oil, castor oil, shea oil, macadamia nut oil, acetic acid lanolin, liquid lanolin; Higher alcohols such as stearyl alcohol and oleyl alcohol; silicone oils such as methylphenylpolysiloxane, dodecamethylcyclohexasiloxane, methylhydrogenpolysiloxane, decamethylcyclopentasiloxane, and octamethylcyclotetrasiloxane; and the like.

The content of liquid oil must be 30% to 95% of the present oral composition, preferably 35 to 90%, more preferably 40 to 85%. The liquid oil content may be 45% or more, 50% or more, 55% or more, 60% or more, 65% or more, or 70% or more, and 80% or less, 75% or more, based on the present oral composition. % or less, or 70% or less. If the content of the liquid oil component is too low, the amount of the oil component that comes into contact with the oral tissues will decrease, and the coating experience during use will deteriorate. On the other hand, if the liquid oil content is too high, the feeling of use in the oral cavity will not be excellent. The liquid oil can be used alone or in combination of two or more.

The nonionic surfactant is not particularly limited as long as it can be applied in the oral cavity. For example, polyoxyethylene aracyl ether (20E.O.), polyoxyethylene octyl dodecyl ether, polyoxyethylene oleyl ether, polyoxyethylene cholesteryl ether, polyoxyethylene stearyl ether, polyoxyethylene myristyl ether, polyoxyethylene lauryl ether , polyoxyethylene cetyl ether, polyoxyethylene behenyl ether, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene decyltetradecyl ether, polyoxyethylene polyoxypropylene butyl ether, etc. Ether type; ethylene glycol monostearate, ethylene glycol distearate, sorbitan monostearate, sorbitan monoisostearate, sorbitan sesquiisostearate, sorbitan sesquistearate, sorbitan monopalmitate, sorbitan monooleate, sorbitan trioleate, Sorbitan stearate, lipophilic glyceryl monostearate, self-emulsifying glyceryl monostearate, etc., polyethylene glycol monooleate, polyethylene glycol monostearate, polyoxyethylene glyceryl monostearate, polyoxyethylene glyceryl isostearate , polyoxyethylene sorbitol tetraoleate, polyoxyethylene sorbitol monolaurate, polyoxyethylene hydrogenated castor oil, polyethylene glycol dilaurate, polyglyceryl distearate, polyglyceryl diisostearate, polyglyceryl decaoleate, diglyceryl triisostearate, polyglyceryl pentaoleate , polyglyceryl monoisostearate, polyglyceryl monooleate, polyglyceryl monostearate, decaglyceryl monomyristate, polyglyceryl monolaurate, etc.; stearic acid monoethanolamide, stearic acid diethanolamide, myristic acid diethanolamide, coconut oil. Examples include fatty acid alkanolamide types such as fatty acid diethanolamide and lauric acid diethanolamide; alkyl glycosides and the like.

The HLB (Hydrophilic-Lipophilic Balance) of the nonionic surfactant is not particularly limited as long as the effects of the present invention are not impaired. It is usually about 3 to 18, preferably about 4 to 16, more preferably about 5 to 13. Furthermore, if the HLB value of the nonionic surfactant is too low, the surfactant may have a low affinity with hydrophilic oral tissues such as tooth surfaces, and may not feel good when used. On the other hand, if the HLB value is too high, withdrawal of the preparation due to water rinsing and dilution with saliva may be promoted, resulting in insufficient oral retention of the composition and composition components.

The content of the nonionic surfactant is not particularly limited as long as the effects of the present invention are not impaired. The amount is usually about 3% to 40%, preferably about 4% to 35%, more preferably about 5% to 30%, based on the oral composition. Furthermore, if the content of the nonionic surfactant is too low, the affinity of the oil base with hydrophilic oral tissues such as tooth surfaces may be low, resulting in poor usability. On the other hand, if the content is too large, the irritation during use may become strong. Nonionic surfactants can be used alone or in combination of two or more.

The oral composition of the present invention can further contain a refreshing agent and/or a sweetening agent. By containing these, even if the composition of the present invention is essentially an oil-based composition, it is very effective because it provides a suitable feeling of use in the oral cavity.

The cooling agent is not particularly limited as long as it can be applied to the oral cavity. For example, menthols, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronel, α-terpineol, methyl acetate, citronenyl acetate, methyl eugenol, cineole, linalool, ethyl linalool, vanillin, thymol. , peppermint oil, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil, and the like. These ingredients may be blended as part of the perfume ingredients.

The content of the refreshing agent is not particularly limited as long as the effect can be obtained. Usually, it can be contained in the oral cavity composition in an amount of about 0.01% to 5%. One type of refreshing agent can be used alone or two or more types can be used in combination.

The sweetener is not particularly limited as long as it can be applied in the oral cavity. Examples include saccharin sodium, acesulfame potassium, stevioside, sorbitol, palatinit, xylitol, erythritol, neohesperidyl dihydrochalcone, glycyrrhizin, perillartin, thaumatin, asparatylphenylalanyl methyl ester, p-methoxycinnamaldehyde, and the like.

The content of the sweetener is not particularly limited as long as its effect can be obtained. Usually, it can be contained in the oral cavity composition in an amount of about 0.01% to 30%. Sweeteners can be used alone or in combination of two or more.

The method for preparing the oral composition of the present invention includes, for example, first stirring and mixing the components (A) and (B), and then adding and mixing the component (C) to the mixture while continuing stirring. There are several methods. Mixing can be performed using a known stirrer.

Furthermore, by further containing a solid oil component, it can be made solid or semi-solid. In this case, the preparation method is to heat the solid oil together with (A) and (B) above the melting point, mix uniformly, add component (C), pour it into a designated container in the molten state, cool it or One method is to let it cool.

The solid oil is not particularly limited as long as it can be applied to the oral cavity and has a melting point of 50 to 120°C. For example, hydrocarbons such as synthetic hydrocarbon wax, polyethylene wax, ethylene-propylene copolymer, microcrystalline wax, ceresin, paraffin, ozokerite, Fischer-Tropsch wax; Japanese wax, carnauba wax, candelilla wax, rice bran wax, beeswax, hydrogenated jojoba oil, Examples include hydrogenated oil, higher alcohol, and silicone wax.

The solid oil content can be 1% to 30%, preferably 2 to 20%, more preferably 3 to 15%, based on the oral composition. The solid oil content may be 5% or more, 8% or more, or 10% or more, and may be 15% or less, 12% or less, or 10% or less with respect to the present oral composition. . If the composition does not contain any solid oil content, the composition will not have sufficient shape retention and will not be in a solid form. On the other hand, if the solid oil content is too high, the dispersibility during use in the oral cavity will decrease. The solid oil can be used alone or in combination of two or more.

The total content of liquid oil and solid oil is 40% to 95%, preferably 50 to 90%, more preferably 70 to 90%, based on the present oral composition. The liquid oil content may be 55% or more, 60% or more, 65% or more, 70% or more, 75% or more, or 80% or more, and 95% or less, 90% or more of the present oral composition. % or less, or 88% or less.

The oral composition of the present invention may contain water, but the water content is 50% or less, 40% or less, 35% or less, 30% or less, 25% or less, 20% or less, 15% Below, it may be 10% or less, or 5% or less, 1% or more, 3% or more, 5% or more, or 10% or more.

The phase state and dispersion state of the oral composition of the present invention are not particularly limited. Examples of the phase state include O (oil) phase alone, W/O, O/W, W/O/W, O/W/O, Bicontinuous, and high internal phase ratio emulsification. Examples of the dispersion state include solubilization, emulsification, two-phase separation, three-phase separation, multiphase separation, and solid-liquid dispersion, and the dispersion may be caused by external force such as shaking during use. However, the oral composition of the present invention is preferably a single-phase oily composition consisting essentially of an oily component. When the oral composition of the present invention contains water, the water may be dispersed in the liquid oil and/or solid oil by a nonionic surfactant.

The dosage form and shape of the oral composition of the present invention are not particularly limited. For example, liquids (solutions, emulsions, suspensions, viscous liquids, etc.), semi-solids (gels, ointments, creams, pastes, etc.), solids (tablets, granules, capsules, films, kneaded materials, molten solids, waxy solids, elastic solids, soft capsules, etc.). However, the oral composition of the present invention is preferably a semi-solid composition.

The oral composition of the present invention can be widely used for oral cavity applications. Oral compositions in solid dosage form include, for example, troches, gummies, gums, and dentifrices. Oral compositions in semi-solid dosage form include, for example, dentifrices and liniments. Examples of liquid oral compositions include mouthwashes, dentifrices, and mouth fresheners (sprays, etc.). Among these, from the viewpoint of effectiveness and stability, dentifrices, liniments, mouth washes, and mouth fresheners are preferred. The method for producing the oral composition is not particularly limited, and can be prepared by any conventional method depending on the dosage form.

The oral composition of the present invention may contain known components that can be included in the oral composition to the extent that the effects of the present invention are not impaired. The oral composition of the present invention containing such components can be prepared, for example, by mixing components (A) and (B), and then adding and mixing the components together with component (C). can do.

Examples of such known components include wetting agents, foaming agents, thickeners, abrasives, flavoring agents, astringents, pH adjusters, coloring agents, preservatives, active ingredients, and the like. Note that such known components can be used alone or in combination of two or more.

Examples of wetting agents include ethanol, ethylene glycol, propanediol, polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, and sorbitol.

Examples of the blowing agent include sodium lauryl sulfate, sodium lauroyl sarcosine, sodium dodecylbenzenesulfonate, sodium lauryl sulfoacetate, N-lauryldiaminoethylglycine, sodium lauryl sulfosuccinate, sodium N-palmitoylglutamate, N-methyl-N- Sodium acyl taurine, sodium α-olefin sulfonate, betaine lauryldimethylaminoacetate, betaine coconut oil fatty acid amidopropyldimethylaminoacetate, N-coco fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, coconut oil Examples include fatty acid amidopropyl betaine.

Examples of the thickener include sodium carboxymethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, gellan gum, xanthan gum, gum arabic, carrageenan, and thickening silica.

Examples of the polishing agent include anhydrous silicic acid, calcium silicate, calcium carbonate, calcium pyrophosphate, calcium phosphate, aluminum oxide, aluminum hydroxide, bentonite, and hydroxyapatite.

Examples of the flavoring agent include tea extract, tea carbonization solution, magnesium chloride, propolis extract, sodium glutamate, and the like.

Examples of the astringent include aluminum lactate, sodium hydrogen carbonate, zinc chloride, zinc oxide, and sodium chloride.

Examples of pH adjusting agents include citric acid, phosphoric acid, lactic acid, pyrophosphoric acid, malic acid, phytic acid, tartaric acid, glycerophosphoric acid, nitric acid, acetic acid, or chemically possible salts thereof; sodium hydroxide, silicic acid. Examples include sodium.

Examples of the coloring agent include Blue No. 1, Green No. 3, Yellow No. 4, ultramarine, deep blue, titanium oxide, titanium mica, and the like.

Examples of preservatives include methylparaben, ethylparaben, propylparaben, butylparaben, sodium benzoate, alkyldiaminoethylglycine hydrochloride, and phenoxyethanol.

Active ingredients include anti-inflammatory agents, emulsifiers, sterilizers and disinfectants, vitamins, adsorbents, whitening agents, remineralization promoters, hypersensitivity inhibitors, tartar removers, enzymes, bone forming agents, and dentin. Coating agents and the like can be mentioned. Examples of anti-inflammatory agents include sodium azulene sulfonate, ε-aminocaproic acid, allantoin, aluminum chlorohydroxyallantoin, glycyrrhizic acids, glycyrrhetinic acid, lysozyme chloride, sodium copper chlorophyllin, and tranexamic acid. Further, examples of the emulsification aid include dihydrocholesterol and the like. Examples of disinfectants include isopropylmethylphenol, cetylpyridinium chloride, dequalinium chloride, benzalkonium chloride, benzethonium chloride, chlorhexidine salts, triclosan, hinokitiol, sodium lauroylsarcosine, histidine, and the like. Additionally, basic amino acids such as arginine, lysine, citrulline, ornithine, creatine, diaminobutanoic acid, and diaminopropionic acid are useful as disinfectants for cariogenic bacteria. Examples of vitamins include ascorbic acid or its salts, pyridoxine hydrochloride, dl-α-tocopherol acetate, dl-α-tocopherol nicotinic acid, and the like. Examples of the adsorbent include zeolite, cyclodextrins, copper gluconate, and the like. Examples of the whitening agent include sodium pyrophosphate, sodium polyphosphate, condensed phosphates such as metaphosphates, hydrogen peroxide, and the like. Examples of remineralization promoters include sodium fluoride, sodium monofluorophosphate, stannous fluoride, lysozyme chloride, sodium copper chlorophyllin, and the like. Examples of hypersensitivity suppressants include potassium nitrate, potassium chloride, aluminum lactate, strontium acetate, and the like. Examples of tartar removers include dextranase, mutanase, and the like. Examples of enzymes include amylase, protease, and lytic enzyme. Examples of the bone forming agent include bioactive glass. Examples of dentin coating agents include pyrrolidone carboxylic acid and the like. Other active ingredients include flavonoids, plant extracts, and lactic acid bacteria.

The oral composition of the present invention can further contain a water-soluble polymer having a color removal effect and/or a bleaching effect. By including these, the whitening effect of the composition of the present invention can be further enhanced, which is very effective. Water-soluble polymers having a color removal effect and/or a bleaching effect can be used alone or in combination of two or more types.

Examples of water-soluble polymers having color removal effects and/or bleaching effects include polyols such as polyethylene glycol; polyvinyl polymers such as polyvinylpyrrolidone.

The present invention further relates to a method for removing tooth stains by using an oral composition and a toothbrush in combination. By using the composition of the present invention in combination with a toothbrush, stains on teeth can be efficiently removed. The toothbrush may be a regular toothbrush, but is preferably an electric toothbrush.

Hereinafter, the present invention will be explained in more detail, but the present invention is not limited to the following examples. The blending amount values of each component listed in each table also indicate "mass %" unless otherwise specified.

《Preparation of oral composition 1》
A solid composition was prepared by a conventional method according to the composition shown in Table 1 (numbers indicate mass %). The obtained dentifrice composition was used as a sample and evaluated by the following method. The results are also listed in the table.

(Tooth surface coating actual evaluation method)
A panel of four test subjects evaluated the tooth surface coating effect of the oral composition. 0.5 g of the sample solid composition was placed on a toothbrush, and the entire oral cavity was brushed for 3 minutes, and then spitted out. The sensation of tooth surface coating during brushing (during the dissemination of the solid composition into the oral cavity) was evaluated according to the scoring criteria shown below. The average of the scores of the four participants was calculated and evaluated according to the following evaluation criteria. Note that the feeling of tooth surface coating here refers to the feeling that the composition dispersed in the oral cavity clings to the tooth surface.

[Evaluation criteria]
4 points: There was a strong feeling of coating. 3 points: There was a slight feeling of coating. 2 points: There was almost no feeling of coating. 1 point: There was no feeling of coating.

[4-stage judgment criteria]
◎: Average score is 3.5 points or more ○: Average score is 3.0 points or more, less than 3.5 points △: Average score is 2.0 points or more, less than 3.0 points ×: Average score is 2.0 points less than a point

(Flavor usability evaluation method)
The feeling of use of the oral composition was evaluated by a panel of four test subjects. 0.5 g of the sample solid composition was placed on a toothbrush, and the entire oral cavity was brushed for 3 minutes, and then spitted out. The flavor during brushing (during the dissemination of the solid composition into the oral cavity) was evaluated according to the scoring criteria shown below. The average of the scores of the four participants was calculated and evaluated according to the following evaluation criteria.

[Evaluation criteria]
4 points: I didn't feel any discomfort (strange taste, unpleasant smell) in my mouth 3 points: I almost didn't feel any discomfort (strange taste, unpleasant smell) inside my mouth 2 points: I didn't feel any discomfort (strange taste, unpleasant smell) inside my mouth 1 point: I felt quite a bit of discomfort (unpleasant taste/odor) in my mouth.

As shown in Table 1, the oral cavity compositions of Examples 1 to 8 exhibited good tooth surface coating feeling and feeling of use. Although the oral cavity composition of Example 9 did not have a good feeling in use because it did not contain a refreshing agent, it showed a good tooth surface coating feeling.

《Preparation of oral composition 2》
A liquid composition was prepared by a conventional method according to the composition shown in Table 2 (numbers indicate mass %). The obtained dentifrice composition was used as a sample and evaluated by the following method. The results are also listed in the table.

(Tooth surface coating actual evaluation method)
A panel of four test subjects evaluated the tooth surface coating effect of the oral composition. 10 mL of the sample liquid composition was placed in the mouth, rinsed for 20 seconds, and then spitted out. The tooth surface coating feeling during rinsing (during dispersion of the liquid composition into the oral cavity) was evaluated according to the scoring criteria shown below. The average of the scores of the four participants was calculated and evaluated according to the following evaluation criteria. Note that the feeling of tooth surface coating here refers to the feeling that the composition dispersed in the oral cavity clings to the tooth surface.

(Flavor usability evaluation method)
The feeling of use of the oral composition was evaluated by a panel of four test subjects. 10 mL of the sample liquid composition was placed in the mouth, rinsed for 20 seconds, and then spitted out. The flavor during rinsing (during dispersion of the liquid composition into the oral cavity) was evaluated according to the scoring criteria shown below. The average of the scores of the four participants was calculated and evaluated according to the following evaluation criteria.

These evaluation criteria and four-stage criteria were the same as those used for Preparation 1 of the oral composition.

As shown in Table 2, the oral cavity compositions of Examples 10 to 19 exhibited good tooth surface coating feeling and feeling of use. Although the oral cavity composition of Example 20 did not have a good feeling of use because it did not contain a refreshing agent, it showed a good tooth surface coating feeling.

Prescription examples of the oral composition of the present invention are shown below. In addition, the compounding amount (%) of each prescription example shows mass %. The following formulation showed good tooth surface coating feeling and usability.

Claims

(A) 30 to 95% by mass of liquid oil,
(B) An oral composition containing one or more nonionic surfactants.
The oral composition according to claim 1, wherein the liquid oil is an ester compound.
The oral composition according to claim 2, wherein the liquid oil is a saturated fatty acid ester compound.
The oral composition according to claim 1, wherein the one or more nonionic surfactants have an HLB value of 5 to 13.
The oral composition according to claim 1, further comprising 1 to 30% by mass of solid oil having a melting point of 50 to 120°C.
The oral composition according to claim 5, wherein the solid oil is a hydrocarbon.
The oral composition according to claim 1, further comprising (C) a refreshing agent and/or a sweetener that can be applied to the oral cavity.
The oral composition according to claim 1, further comprising a condensed phosphate, wherein the condensed phosphate is one or more selected from the group consisting of pyrophosphate, tripolyphosphate, and metaphosphate.
Claim 1 further comprising a sterilizing/disinfecting agent, an anti-inflammatory agent, and/or vitamins, wherein the sterilizing/disinfecting agent is isopropylmethylphenol or cetylpyridinium chloride, and the anti-inflammatory agent is glycyrrhizinic acids or glycyrrhetinic acid. Oral composition according to.
The oral cavity composition according to claim 1, further comprising one or more water-soluble polymers having a color removal effect and/or a bleaching effect on dental hard tissues.
A method for removing tooth stains by using the oral composition according to any one of claims 1 to 9 in combination with an electric toothbrush.