CN102198153A - Nano-silver spray for treating skin diseases, and preparation method thereof - Google Patents
Nano-silver spray for treating skin diseases, and preparation method thereof Download PDFInfo
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- CN102198153A CN102198153A CN 201110158663 CN201110158663A CN102198153A CN 102198153 A CN102198153 A CN 102198153A CN 201110158663 CN201110158663 CN 201110158663 CN 201110158663 A CN201110158663 A CN 201110158663A CN 102198153 A CN102198153 A CN 102198153A
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Abstract
The invention discloses a nano-silver spray for treating skin diseases, and a preparation method thereof, aiming at providing a medicament prepared from nano-silver as a raw material for treating skin disease. The nano-silver spray comprises the following components in mass percent: 0.05-0.1% of nano-silver solution, 0.5-5% of miconazole nitrate, 0.5-1% of azone, 50-80% of alcohol, 0.01-0.05% of essence and purified water. The preparation method comprises the following steps of: adding the miconazole nitrate into a reaction kettle, then adding the alcohol, heating and stirring for reacting for 1-2 hours; adding the azone and the nano-silver solution, stirring for reacting for 1-2 hours; and adding the purified water and the essence, diluting and stirring for 0.5-1 hour, filtering and filling to obtain finished products. The nano-silver spray disclosed by the invention is applied to skin diseases such as tinea pedis, tinea manuum, tinea corporis, tinea cruris, psoriasis, dermatitis and the like, is especially suitable for patients with psoriasis inveterata, and has notable curative effects, convenience in use, safety and no side effects proven by clinical practice.
Description
Technical field
The present invention relates to the dermopathic spray of a kind of treatment, be specifically related to a kind of treatment dermatosis nano silver spray and preparation method thereof.
Background technology
In life, be flooded with various harmful fungoids, antibacterial, virus, bring various diseases to people, particularly harmful fungoid, antibacterial corrode human body skin, cause in a large number such as tinea pedis (vitamin B1 deficiency), the tinea manuum, tinea corporis, tinea cruris, psoriasis (psoriasis), dermatitis, men and women's genitals dermatosis or the like.These dermatosiss make to be suffered from patient's pain pruritus and propagates infection easily, and outbreak has a strong impact on life and work repeatedly.
Silver just is widely used at biomedical sector since ancient times.Nanometer silver powder as a kind of specific form of argent has broad-spectrum antiseptic, and is potent antibiotic, the special efficacy of durable antibiotic.The cell wall-bound of nano-Ag particles and pathogen, (SH) combine, make enzyme deactivation, the blocking-up respiratory metabolism is choked to death it, and sodium rice silver can kill 650 various bacteria in several minutes with the oxo enzyme rapidly directly to enter thalline.Sodium rice silver has superpower permeability, can infiltrate subcutaneous 2mm sterilization rapidly, and the subcutaneous fungus of the dermatosis of stubbornness, antibacterial are had good bactericidal action, and sodium rice silver has layer protecting film outward, so it is lasting to discharge antibacterial effect in vivo gradually.
Purpose of the present invention is exactly that a kind of nanometer silver that uses of development is the dermopathic medicine of the treatment of feedstock production.
Summary of the invention
The purpose of this invention is to provide a kind of treatment dermatosis nano silver spray and preparation method thereof.
The present invention is achieved by the following technical solutions:
A kind of treatment dermatosis nano silver spray comprises following components by mass percentage:
Sodium rice silver solution 0.05-0.1%
Miconazole nitrate 0.5-5%
Azone 0.5-1%
Alcohols 50-80%
Essence 0.01-0.05%
The pure water surplus.
Described miconazole nitrate is by wherein a kind of of econazole nitrate, acetic acid tralonide, metronidazole, tinidazole, chlorhexidine acetate, triclosan or severally arbitrarily replace with arbitrary proportion.
Described alcohols is an ethanol.
The treatment dermatosis preparation method of nano silver spray may further comprise the steps:
(1) accurately the miconazole nitrate of weighing 0.5-5% is put into reactor, adds the alcohols of 50-80% again, heats to 20-30 ℃, and stirring reaction 1-2 hour, complex liquid must sterilize;
(2) in the sterilization complex liquid, add 0.5-1% azone, 0.05-0.1% nanometer silver solution, stirring reaction 1-2 hour, get the bactericidal nano-silver complex liquid;
(3) add pure water and essence in the bactericidal nano-silver complex liquid, dilution was stirred 0.5-1 hour, got spray finished product complex liquid;
(4) spray finished product complex liquid is stirred, go into jar after the inorganic membrane filtration machine filters, fill then, seal package get product.
Treatment dermatosis of the present invention with nano silver spray after testing, killing rate to escherichia coli, golden yellow Staphylococcus aureus, Candida albicans all reaches＞more than 90%, belong to non-stimulated, avirulence product through the animal toxicology test, and PH is determined as 6, belong to neutrality, skin is not had injury.
Drug use of the present invention is specially adapted to suffer from the intractable psoriatic in dermatosiss such as tinea pedis, the tinea manuum, tinea corporis, tinea cruris, psoriasis, dermatitis, proves through clinical practice in 8 years, this spray is evident in efficacy, easy to use, safety has no side effect, and is subjected to the welcome of vast dermatosis patient deeply.
The specific embodiment
Embodiment 1
A kind of treatment dermatosis nano silver spray comprises following components by mass percentage: 0.05% sodium rice silver solution, 0.5% miconazole nitrate, 1% azone, 65% alcohols, 0.03% essence, 33.42% pure water.
Miconazole nitrate is added in the reactor, add alcohols again, be warming up to 30 ℃ of stirring reactions 1 hour, add azone, nanometer silver solution again in reactor, cooling was stirred 2 hours, added pure water and essence again in still, stirring at room 0.5 hour, filter standby, fill.
Embodiment 2
A kind of treatment dermatosis nano silver spray comprises following components by mass percentage: 0.1% sodium rice silver solution, 1.5% miconazole nitrate, 0.5% econazole nitrate, 1.5% triclosan, 0.5% azone, 50% ethanol, 0.01% essence, 45.89% pure water.
Miconazole nitrate, econazole nitrate, triclosan are added in the reactor, add ethanol again, be warming up to 25 ℃ of stirring reactions 2 hours, in reactor, add azone, nanometer silver solution again, cooling was stirred 1 hour, added pure water and essence, stirring at room 1 hour again in still, filter standby, fill.
Embodiment 3
A kind of treatment dermatosis nano silver spray comprises following components by mass percentage: 0.08% sodium rice silver solution, 1.5% metronidazole, 1.5% chlorhexidine acetate, 0.5% triclosan, 0.8% azone, 80% propanol, 0.05% essence, 15.57% pure water.
Metronidazole, chlorhexidine acetate, triclosan are added in the reactor, add propanol again, be warming up to 30 ℃ of stirring reactions 2 hours, add azone, nanometer silver solution again in reactor, cooling was stirred 2 hours, added pure water and essence again in still, stirring at room 1 hour, filter standby, fill.
Embodiment 4
A kind of treatment dermatosis nano silver spray comprises following components by mass percentage: 0.08% sodium rice silver solution, 1.5% econazole nitrate, 1.5% chlorhexidine acetate, 0.5% tinidazole, 0.8% azone, 80% ethanol, 0.05% essence, 15.57% pure water.
Econazole nitrate, chlorhexidine acetate, tinidazole are added in the reactor, add ethanol again, be warming up to 30 ℃ of stirring reactions 2 hours, in reactor, add azone, nanometer silver solution again, cooling was stirred 2 hours, added pure water and essence, stirring at room 1 hour again in still, filter standby, fill.
Claims (4)
1. treat the dermatosis nano silver spray for one kind, it is characterized in that comprising following components by mass percentage:
Sodium rice silver solution 0.05-0.1%
Miconazole nitrate 0.5-5%
Azone 0.5-1%
Alcohols 50-80%
Essence 0.01-0.05%
The pure water surplus.
2. treatment dermatosis nano silver spray according to claim 1 is characterized in that described miconazole nitrate is by wherein a kind of of econazole nitrate, acetic acid tralonide, metronidazole, tinidazole, chlorhexidine acetate, triclosan or severally arbitrarily replace with arbitrary proportion.
3. treatment dermatosis nano silver spray according to claim 1 and 2 is characterized in that described alcohols is an ethanol.
4. the described treatment dermatosis of claim 1 is characterized in that may further comprise the steps with the preparation method of nano silver spray:
(1) accurately the miconazole nitrate of weighing 0.5-5% is put into reactor, adds the alcohols of 50-80% again, heats to 20-30 ℃, and stirring reaction 1-2 hour, complex liquid must sterilize;
(2) in the sterilization complex liquid, add 0.5-1% azone, 0.05-0.1% nanometer silver solution, stirring reaction 1-2 hour, get the bactericidal nano-silver complex liquid;
(3) add pure water and essence in the bactericidal nano-silver complex liquid, dilution was stirred 0.5-1 hour, got spray finished product complex liquid;
(4) spray finished product complex liquid is stirred, go into jar after the inorganic membrane filtration machine filters, fill then, seal package get product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110158663 CN102198153A (en) | 2011-06-14 | 2011-06-14 | Nano-silver spray for treating skin diseases, and preparation method thereof |
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| CN 201110158663 CN102198153A (en) | 2011-06-14 | 2011-06-14 | Nano-silver spray for treating skin diseases, and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688258A (en) * | 2012-06-16 | 2012-09-26 | 李泽红 | Medicine for external use for treating psoriasis, leucoderma, fungus infection and bromhidrosis |
| CN104906135A (en) * | 2014-03-11 | 2015-09-16 | 中国人民解放军第二军医大学 | Applications of nanometer silver in preparation of antifungal drug synergists |
| CN106727924A (en) * | 2017-01-18 | 2017-05-31 | 普宁康特生物科技有限公司 | A kind of antiseptic solution |
| CN107334782A (en) * | 2017-07-26 | 2017-11-10 | 吉林省始祖生物波医学研究院有限公司 | A kind of inhibiting bacteria and diminishing inflammation agent and its preparation method and application |
| CN107455387A (en) * | 2017-07-25 | 2017-12-12 | 佛山市南海建诺鞋业有限公司 | A kind of formula of PU bactericidal creams and preparation method thereof |
| CN110742905A (en) * | 2019-12-04 | 2020-02-04 | 武汉维斯第医用科技股份有限公司 | Silver-containing wound care solution and preparation method thereof |
| CN111450058A (en) * | 2020-04-17 | 2020-07-28 | 于力 | Preparation of nano zero-valent silver spray for sterilizing and healing animal wound and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1380060A (en) * | 2002-04-28 | 2002-11-20 | 中国人民解放军第二军医大学 | Solution type spray of antimycotic medicine for external application and its preparation method |
| CN101229126A (en) * | 2008-01-23 | 2008-07-30 | 西北农林科技大学 | Tinidazole compound nano silver microemulsion antibacterial medicine |
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2011
- 2011-06-14 CN CN 201110158663 patent/CN102198153A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1380060A (en) * | 2002-04-28 | 2002-11-20 | 中国人民解放军第二军医大学 | Solution type spray of antimycotic medicine for external application and its preparation method |
| CN101229126A (en) * | 2008-01-23 | 2008-07-30 | 西北农林科技大学 | Tinidazole compound nano silver microemulsion antibacterial medicine |
Non-Patent Citations (1)
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| 《时珍国医国药》 20021231 马平勃 银屑净喷雾剂的制备及临床应用 75 1-4 第13卷, 第2期 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688258A (en) * | 2012-06-16 | 2012-09-26 | 李泽红 | Medicine for external use for treating psoriasis, leucoderma, fungus infection and bromhidrosis |
| CN104906135A (en) * | 2014-03-11 | 2015-09-16 | 中国人民解放军第二军医大学 | Applications of nanometer silver in preparation of antifungal drug synergists |
| CN104906135B (en) * | 2014-03-11 | 2018-01-30 | 中国人民解放军第二军医大学 | Application of the Nano Silver in antifungal medicine synergist is prepared |
| CN106727924A (en) * | 2017-01-18 | 2017-05-31 | 普宁康特生物科技有限公司 | A kind of antiseptic solution |
| CN107455387A (en) * | 2017-07-25 | 2017-12-12 | 佛山市南海建诺鞋业有限公司 | A kind of formula of PU bactericidal creams and preparation method thereof |
| CN107334782A (en) * | 2017-07-26 | 2017-11-10 | 吉林省始祖生物波医学研究院有限公司 | A kind of inhibiting bacteria and diminishing inflammation agent and its preparation method and application |
| CN110742905A (en) * | 2019-12-04 | 2020-02-04 | 武汉维斯第医用科技股份有限公司 | Silver-containing wound care solution and preparation method thereof |
| CN111450058A (en) * | 2020-04-17 | 2020-07-28 | 于力 | Preparation of nano zero-valent silver spray for sterilizing and healing animal wound and preparation method thereof |
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Application publication date: 20110928 |