CN100450505C - Chinese medicinal ointment for treating beriberi - Google Patents

Abstract

The present invention relates to a Chinese medicinal ointment for treating beriberi, which is characterized in that wild or planted japanese dock root is processed by the steps of impurity removing, cleaning, slicing, pulverizing, drying, ethanol leaching, concentrating, powder preparing by freeze drying, ointment medicine preparing, gruel substrate preparing by adding auxiliary materials, medicinal ointment preparing, sterilizing and packaging. The Chinese medicinal ointment for treating beriberi inhibits and kills trichophyton rubrum and other pathogenic bacteria by mainly utilizing ingredients, such as emodin, rumicin, etc., in the root part of the japanese dock root and achieves the purpose of healing beriberi, and beriberi is not apt to relapse after a long time. The Chinese medicinal ointment for treating beriberi is externally used and has the advantages of convenient use, simple preparation process and low cost. The clinical trial of the ointment is completed, and clinical application of the ointment is carried out to 5000 patients with erosive type, water blister type, chap type and foot odor diseases. Effectual rate reaches more than 95 percent, and total effective rate is more than 99 percent.

Description

The beriberic Chinese medicine beriberi paste of a kind of treatment

Technical field

The present invention is a field of pharmaceutical technology, relates to the beriberic Chinese medicine beriberi paste of a kind of treatment.

Background technology

The dermatosis of beriberi class is the dermatosis that a kind of fungal infection is propagated, and is a kind of commonly encountered diseases, frequently-occurring disease.Traditional method that is used for the treatment of beriberi is to be applied to the affected part outside medicine is direct, and medicine is treated in the tissue of human body by dermal osmosis.Common on the market have various medicines that anti-dermatophytes such as beriberi, tinea cruris, tinea corporis infect that are used for the treatment of, as zinci undecylenatis compositum, JIAOXIAN YICIJING etc.Be used for the treatment of beriberi footwear, shoe pad, socks etc. in addition, these methods are because its antibiotic composition deficiency can't be killed the skin corium courses of infection and have defectives such as the length course of treatment, weak curative effect, disease relapse rate height, and clinical effectiveness is undesirable.

Summary of the invention

The present invention is in order to overcome the defective that said medicine treatment beriberi class dermatosis etc. exists, purpose is more effective treatment beriberi class dermatosis, provide a kind of can to erosive type, vesicle type, the type of chapping and foot odor be cured and the Chinese medicine unguentum that do not recur, offend again for a long time.

The present invention is the beriberic Chinese medicine beriberi paste of a kind of treatment, its content Description:

The beriberic Chinese medicine beriberi paste of a kind of treatment of the present invention, it is characterized in that: it is by Radix Rumicis Crispi wild or plantation, makes medicated porridge shape thing substrate → make ointment → sterilization, pack through removing impurity → cleanings → section, pulverizing → drying → ethanol lixiviate → concentrate → be lyophilized into powder → make cream drug → add adjuvant;

It prepares with the following method to treat beriberic Chinese medicine beriberi paste:

(1), with the bright Radix Rumicis Crispi cleaning of wild or plantation, cut into slices shape or fritter shape after drying;

(2), with dried bright Radix Rumicis Japonici heel piece or piece, be contained in the rustless steel container, add concentration and be 70～80% ethanol, soaked 7～10 days, under 30～50 ℃ of temperature conditions, carry out homogenizing about the repeated multiple times, make standby lixiviate medicinal liquid;

(3), will make standby lixiviating solution through vacuum extraction, the temperature in the container is 40～65 ℃, and ethanol is all taken out, water takes out about 50%, remainder is spissated cream drug;

(4), spissated cream drug placed quick-freezing under-35～-40 ℃ the temperature, drying, lyophilizing in 15～20 hours is a powdered drug;

(5), get by weight: powdered drug 20%, distilled water 40%, sodium carboxymethyl cellulose 2%, stir after the mixing, make cream drug;

(6), get by weight: salicylic acid 3%, sulfur 3%, benzoic acid 5%, dimethyl sulfoxide 6%, menthol 1%, glycerol 5%, carbamide 15%, mix, grind well, make medicated porridge shape thing substrate;

(7), cream drug and the medicated porridge shape thing substrate of making is mixed, stir, make cream;

(8), cream is sterilized, packed.

The present invention is the beriberic Chinese medicine beriberi paste of a kind of treatment, mainly be compositions such as the emodin that utilizes the Radix Rumicis Crispi root contained, rumicin, suppress, kill trichophyton and other pathogenic bacterium, and reach the beriberic purpose of healing, and be difficult for recurrence, major criminal for a long time.The Chinese medicine beriberi paste is an externally used paste, easy to use, preparation technology is simple, with low cost.Clinical trial of the present invention is finished, and routine erosive type, vesicle type, the type of chapping and smelly foot patient surplus 5000 have been carried out clinical practice, and obvious effective rate reaches more than 95%; Always effectively be more than 99%.

The specific embodiment

The beriberic Chinese medicine beriberi paste of a kind of treatment of the present invention, be to realize like this, it is by Radix Rumicis Crispi wild or plantation, makes medicated porridge shape thing substrate → make ointment → sterilization, pack through removing impurity → cleanings → section, pulverizing → drying → ethanol lixiviate → concentrate → be lyophilized into powder → make cream drug → add adjuvant.

Follow these steps to finish:

(1), with the bright Radix Rumicis Crispi cleaning of wild or plantation, cut into slices shape or fritter shape after drying;

(2), with dried bright Radix Rumicis Japonici heel piece or piece, be contained in the rustless steel container, add concentration and be 70～80% ethanol, soaked 7～10 days, under 30～50 ℃ of temperature conditions, carry out homogenizing about the repeated multiple times, make standby lixiviate medicinal liquid;

(3), will make standby lixiviating solution through vacuum extraction, the temperature in the container is 40～65 ℃, and ethanol is all taken out, water takes out about 50%, remainder is spissated cream drug;

(4), spissated cream drug placed quick-freezing under-35～-40 ℃ the temperature, drying, lyophilizing in 15～20 hours is a powdered drug;

(5), every 10g dress of preparation is prepared by following method for the Chinese medicine beriberi paste of example:

Get major ingredient: powdered drug 2g, distilled water 4g, carboxylic potassio sodium cellulosate 0.2g, stir after the mixing, make cream drug;

Get adjuvant: salicylic acid 0.3g, sulfur 0.3g, benzoic acid 0.5g, dimethyl sulfoxide 0.6g, menthol 0.1g, glycerol 0.5g, carbamide 1.5g, mix, grind well, make medicated porridge shape thing substrate;

Cream drug of making and medicated porridge shape thing substrate mix, and stir, and make the Chinese medicine beriberi paste; Sterilize, pack.

Using method: will treat after beriberic Chinese medicine beriberi paste is applied to the affected part, and rub repeatedly and put on the skin, and take effect about a week every day 1～2 time, and be difficult for recurrence, major criminal for a long time.

Claims (1)

1, the beriberic Chinese medicine beriberi paste of a kind of treatment, it is characterized in that: it prepares with the following method:

(1), with the bright Radix Rumicis Crispi cleaning of wild or plantation, cut into slices shape or fritter shape after drying;

(2), with dried bright Radix Rumicis Japonici heel piece or piece, be contained in the rustless steel container, add concentration and be 70～80% ethanol, soaked 7～10 days, under 30～50 ℃ of temperature conditions, carry out homogenizing about the repeated multiple times, make standby lixiviate medicinal liquid;

(3), will make standby lixiviating solution through vacuum extraction, the temperature in the container is 40～65 ℃, and ethanol is all taken out, water takes out about 50%, remainder is spissated cream drug;

(4), spissated cream drug placed quick-freezing under-35～-40 ℃ the temperature, drying, lyophilizing in 15～20 hours is a powdered drug;

(5), get by weight: powdered drug 20%, distilled water 40%, sodium carboxymethyl cellulose 2%, stir after the mixing, make cream drug;

(6), get by weight: salicylic acid 3%, sulfur 3%, benzoic acid 5%, dimethyl sulfoxide 6%, menthol 1%, glycerol 5%, carbamide 15%, mix, grind well, make medicated porridge shape thing substrate;

(7), cream drug and the medicated porridge shape thing substrate of making is mixed, stir, make cream;

(8), cream is sterilized, packed.