CN101766650B - Washing liquor for operation and method for preparing same - Google Patents
Washing liquor for operation and method for preparing same Download PDFInfo
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- CN101766650B CN101766650B CN2010101131280A CN201010113128A CN101766650B CN 101766650 B CN101766650 B CN 101766650B CN 2010101131280 A CN2010101131280 A CN 2010101131280A CN 201010113128 A CN201010113128 A CN 201010113128A CN 101766650 B CN101766650 B CN 101766650B
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Abstract
The invention discloses washing liquor for an operation and a method for preparing the same, which belong to the technical field of medicaments for medical operations. Each 1,000 g of washing liquor finished product comprises 0.08 to 0.16 g of silver powder, 0.3 to 0.5 g of stabilizing agent, 0.3 to 0.5 g of suspending agent, 0.2 to 0.3 g of ternary acid, 6 to 8 g of bactericide and the balance of water. The technical scheme provided by the invention has the advantages of strong effect, controlled release, strong broad-spectrum antibacterial property and permeability, wound healing promotion, no drug resistance, contribution to tissue repair and regeneration and scar formation prevention, safety, no toxicity and no irritation; therefore, the washing liquor is suitable for washing in the operation. The preparation method of the invention has fewer steps and easy process condition, and is favorable for industrial scaled-up production.
Description
Technical field
The invention belongs to medical operating medication technical field, be specifically related to a kind of surgical flush fluid, and relate to the preparation method of surgical flush fluid.
Background technology
Surgical flush fluid in the wide clinical application of medical department (hospital) has hibitane flushing liquor, bromo geramine flushing liquor, JIEERYIN flushing liquor, metronidazole flushing liquor, gentamycin normal saline flushing liquid, mannitol flushing liquor, povidone iodine flushing liquor, carboxymethyl chitin normal saline flushing liquid at present, or the like.Though these surgical flush fluids can satisfy clinical instructions for use, there is following shortcoming: the one, a little less than the antibacterial and antibiotic effect, easily cause surgical adhesions and traumatic infection; The 2nd, the wound healing cycle is long; The 3rd, do not have the tissue repair of promotion and regenerated effect, be difficult to avoid the generation of cicatrix; The 4th, be easy to generate Resistant strain.
At the patent documentation report of existing flushing liquor in the Chinese patent literature particularly, and many flushing liquors are that notion with disinfectant occurs.Application for a patent for invention publication number CN1262101A discloses a kind of silver ion disinfectant and preparation method thereof, consisting of of silver ion disinfectant: reactive metal silver ion solution, edible-type fruit acid and deionized water, preparation method is: active silver ion solution, edible-type fruit acid and deionized water are stirred (5-9 is capable for Instructions Page 2) down at 40-120 ℃.The resulting silver ion disinfectant of this scheme only can be for the sterilization in people's daily life, as vagina sterilization cleaning solution, and specifically can be referring to the Instructions Page 2 final stage.
Invention patent mandate notification number CN1090905C has recommended powerful disinfectant, the purity that comprises 0.01-0.02 part weight in the finished product liquor of per 100 parts of weight be 99.9% argentum powder ,≤the hydrogen peroxide cosolvent of 0.01 part of weight and≤the ethylenediaminetetraacetic acid stabilizing agent of 0.01 part of weight, all the other are distilled water.Though the powerful disinfectant of this patent scheme has the alleged technique effect of Instructions Page 2 the 2nd to 7 row, but only can be used for sterilization to wrapping paper, wet paper towel, food pack, tableware, bathroom facilities and articles for children, promptly be applicable to daily living utensil sterilization, specifically can be referring to Instructions Page 2 the 8th to 11 row of this patent.
Invention patent mandate notification number CN1134213C has disclosed the preparation method of bactericide containing silver, though this patent scheme is not mentioned purposes in description, but from its used raw material and the target product (bactericide containing silver) that obtains as can be known, can only be used for the people produces the disinfecting utensils of daily life or human oral cavity sterilization as is applied in the collutory.
Hence one can see that, and aforesaid three pieces of disclosed antibacterial of patent documentation all are not the surgical flush fluid categories, and for the instructive of exploitation surgical flush fluid on not possessing skills.For this reason, the applicant has done more deep retrieval, search one piece of comparatively representational and patent documentation that belong to the surgical flush fluid category and be Granted publication CN100420446C public all " a kind of surgical flush fluid and its production and application ".This patented technology scheme is based on that ZL92106578.7 (a kind of carboxymethyl chitosan), ZL01107718.2, ZL00111646.0 and application number 200510045472.X are existing not to have the effect that prevents surgical adhesions and propose.This patent scheme has in that Instructions Page 2 10-11 is capable and alleged have the function and the good stability of surgery washing and prevention surgical adhesions and have no side effect, but prescription is complicated, antibacterial and antibiotic effect is low, poor to the endurance strain killing effect, to lack promotion tissue repair and regenerated effect and be difficult to avoid the generation of cicatrix be the deficiency of this patent.Therefore, the applicant thinks and still has improved necessity.
Summary of the invention
Task of the present invention be to provide a kind of had both had surgery washing and prevent the surgical adhesions function and prescription simple, have has a broad antifungal spectrum again, promote wound healing, good, safe, nontoxic and non-stimulated to the Resistant strain killing effect, help tissue repair and regeneration and avoid the surgical flush fluid of cicatrix generation.
Task of the present invention is also to provide that a kind of processing step is simple, preparation condition is not harsh, can satisfy the preparation method of surgical flush fluid of comprehensive embodiment that suitability for industrialized production required and ensured the technique effect of described surgical flush fluid.
Task of the present invention is finished like this, and a kind of surgical flush fluid comprises in the finished product liquor of every 1000g weight: aluminium powder 0.08-0.16g, stabilizing agent 0.3-0.5g, suspending agent 0.3-0.5g, ternary acid 0.2-0.3g and antibacterial 6-8g, surplus is a water.
In a specific embodiment of the present invention, described aluminium powder is that purity 99.99% and particle diameter are the nano level aluminium powder of 10-25nm.
In another specific embodiment of the present invention, described stabilizing agent is the mannitol of SILVER REAGENT.
In another specific embodiment of the present invention, described suspending agent is medical gelatin or natural silk fibroin.
In another specific embodiment of the present invention, described ternary acid is the phosphoric acid or the citric acid of SILVER REAGENT.
Also have in the specific embodiment of the present invention, described antibacterial be SILVER REAGENT and mass percent concentration be the hydrogen peroxide of 27-28%.
More of the present invention and in specific embodiment, the purity of described water is deionized water or the distilled water of 0.08-0.12 μ s/cm.
An also task of the present invention is finished like this, and a kind of preparation method of surgical flush fluid may further comprise the steps:
A) aluminium powder is added in the entry stir evenly, obtain argentum powder body fluid;
B) ternary acid is joined carry out acidification in the argentum powder body fluid and regulate pH value, obtain the aluminium powder mixed liquor after the acidification;
C) will join behind the stabilizing agent dilute with water in the aluminium powder mixed liquor, stir, obtain stand-by liquid;
D) elder generation is dissolved in the water suspending agent and stirs, and then adds to be used for described suspending agent is carried out the antibacterial that endotoxin inactivation is handled, and stirs then, obtains suspending agent liquid;
E) elder generation joins described stand-by liquid in the container that fills water and stirs, and adds described suspending agent liquid again and continues to stir, and obtains aluminium powder granule covering liquid;
F) the silver powder particles covering liquid is carried out homogenizing and handle, obtain dispersion liquid, the pH value with described ternary acid adjustment dispersion liquid leaves standstill, filtration and fill, obtains the finished product surgical flush fluid.
The processing time of the acidification in of the present invention and then specific embodiment, step B) is 18-30min, and described adjusting pH value is for to be adjusted to 1-1.6 with pH value; The mixing time of the stirring step C) is 15-20min, and mixing speed is 55-65n/min; Step D) the dissolved solution temperature described in is 50-60 ℃ or room temperature, and described stirring and the time of stirring then respectively are 5-10min, and mixing speed is 55-65n/min, and the time that described endotoxin inactivation is handled is 30-35min.
Of the present invention again more and in specific embodiment, step e) time that stirring described in and described continuation are stirred respectively is 5-15min, and mixing speed is 55-65n/min; Step F) temperature that the homogenizing described in is handled is 20-30 ℃, the rotating speed that homogenizing is handled used homogeneous device is 2500-3000n/min, the time that homogenizing is handled is 10-16min, the pH value of described adjustment dispersion liquid is that pH value is adjusted into 5-6, the described time of repose that leaves standstill is 60-80min, the described employing strainer filtering that is filtered into, filter screen are 150 purpose filter screens.
Technical scheme provided by the invention since have potent and long-acting, broad-spectrum antiseptic, permeability strong, promote wound healing, have no drug resistance, help tissue repair and regeneration and prevent cicatrix generation, safe, nontoxic and non-stimulated strong point, so be applicable to surgery washing; The preparation method step of recommending is few, process conditions are not harsh, help industrial amplification production.
The specific embodiment
Five embodiment by the applicant is exemplified below will make the further understanding of deepening the present invention program of the public, and make the present invention program's technique effect brighter and clearer, but embodiment are not the concrete restrictions to the present invention program.
Embodiment 1:
A) will be both can from commercially available channel obtain also can homemade purity be 99.99% and particle diameter be that the nano level aluminium powder of 10-25nm is that to join purity be that the 10g deionized water for stirring of 0.08-0.12 μ s/cm is even to nano silver powder 0.09g, used container both can be a canister, also can be plastic containers, canister such as rustless steel container, plastic containers such as vinyon container, obtain argentum powder body fluid, the used aluminium powder of present embodiment preferred but not with being limited to use by the nano silver powder of Chinese Shanghai De Nafu Nanosolutions GmbH production and sales, the purity of this nano silver powder is 99.99%, particle diameter is 10-25nm, if self-control aluminium powder, can realize by following manner so, earlier be that 99.99% silver granuel or silver bullion drop in the circulating jet mill and pulverize in advance with purity, through pulverizing in advance, can reduce mill feed size, make its powder particle diameter reach micron order, again micron-sized powder body is processed with colloid mill, make micron-sized aluminium powder and the liquid dispersion medium mouthful adding of the axle above colloid mill together through pulverizing in advance, flow out on the contrary and between the metal grinding table of high speed rotating from two directions, so repeat to grind, can be crushed to the particle diameter that needs is 10-25nm, again with the aluminium powder of the 10-25nm that processes through the vacuum dehydration drying, obtain nano silver powder, aforesaid self-control method belongs to the physical pulverization legal system and is equipped with category, yet also can adopt the photochemistry preparation method, specifically be to be raw material with silver nitrate, by the optics preparation, obtain nano silver powder;
B) phosphoric acid with the 0.22g SILVER REAGENT joins by steps A) carry out acidification in the resulting argentum powder body fluid, the time of acidification is 20min, pH value is adjusted to pH=1.1, obtain the aluminium powder mixed liquor after the acidification, the purpose of the acidification of this step is to make aluminium powder more even in disperse medium, prevent coagulation, because silver phosphate is to have electronegative polar group, as anionic dispersing agent is optimum selection, by steps A) to be attached to this step be step B), reuse phosphoric acid carried out acidification after why the applicant joined aluminium powder earlier and stir evenly in the 10g deionized water, was because only this just can make the aluminium powder acidify even, otherwise then could, because the viscosity as the phosphoric acid of ternary acid is big, and addition is limited, thereby can cause the acidify of aluminium powder inhomogeneously, influences the quality of acidification;
C) be to join by step B after the 10g deionized water dilution of 0.08-0.12 μ s/cm the 0.3g mannitol purity of SILVER REAGENT) in the aluminium powder mixed liquor that obtains, and stir 15min, mixing speed is 60n/min, obtain stand-by liquid, the mannitol described in this step preferably adopts the SILVER REAGENT mannitol by Chinese Shanghai reagent one factory's production and selling;
D) earlier be that the medical grade gelatin is dissolved in purity and is similarly in the 10g deionized water of 0.08-0.12 μ s/cm with the 0.35g medical gelatin, solution temperature is 55 ℃, and stir 5min, stir while dissolving, mixing speed is 65n/min, then add and be used for gelatin is carried out the hydrogen peroxide that endotoxin inactivation is handled and mass percent concentration is 27.5% 6.5g SILVER REAGENT, after treating 30min, promptly after the endotoxin inactivation of 30min is handled, then stir 5min, mixing speed is 65n/min, obtain suspending agent liquid, medical grade gelatin in this step preferably adopts the medical grade gelatin by Chinese Qingdao of Shandong province Qingdao gelatin factory production and selling, and this step is carried out endotoxin inactivation to gelatin and handled the safety that can guarantee surgical flush fluid;
E) earlier will be by step C) the stand-by liquid that obtains joins and fills purity and still stir 11min in deionized water and the container that have agitator for the 962.54g of 0.08-0.12 μ s/cm, the rotating speed of agitator is 60n/min, add again by step D) resulting suspending agent liquid, continue to stir 10min, mixing speed is 60n/min, obtain aluminium powder granule covering liquid, also can claim the nanometer silver covering liquid, this step comes down to the aluminium powder granule is coated processing, because gelatin is the macromolecule long-chain polymer, can be adsorbed on the aluminium powder particle surface, after the coating of aluminium powder granule, except playing steric hindrance, also play the mechanism of electrostatic stabilization, promptly produce static steric hindrance stabilizing effect, guarantee that the aluminium powder granule is uniformly dispersed in surgical flush fluid, even when bigger variation takes place temperature, cohesion and coagulation phenomenon can not take place yet, so the performance of flushing liquor is very stable;
F) will be by step e) the aluminium powder granule covering liquid that obtains joins and carries out homogenizing in the homogenizer and handle, the temperature that homogenizing is handled is 25 ℃, the rotating speed of homogenizer is 2600n/min, the time that homogenizing is handled is 11min, obtain dispersion liquid, the pH value of dispersion liquid is adjusted to 5.5, filter with 150 purpose nylon yarn drainage screens after leaving standstill 65min again with phosphoric acid, and fill obtains 1000g surgical flush fluid finished product.
Embodiment 2:
Only with steps A) in the amount of aluminium powder change 0.1g into, and change deionized water into distilled water that purity is 0.08-0.12 μ s/cm;
Only with step B) in phosphoric acid change the 0.24g citric acid of SILVER REAGENT into, the time of acidification changes 24min into, pH value changes 1.2 into;
Only with step C) in the amount of mannitol change 0.35g into, deionized water is used the distilled water that purity is 0.08-0.12 μ s/cm instead, mixing time changes 16min into;
Only with step D) in the amount of medical gelatin change 0.38g into, use deionized water instead distilled water that purity is 0.08-0.12 μ s/cm, solution temperature changes 58 ℃ into, the time of stirring and stirring then respectively changes 8min into, the mass percent concentration of hydrogen peroxide changes 27% into, the amount of hydrogen peroxide changes 6.8g into, and the time that endotoxin inactivation is handled changes 35min into;
Only with step e) in deionized water use the distilled water that purity is the 962.13g of 0.08-0.12 μ s/cm instead, mixing time changes 12min into, the time of continue stirring changes 11min into;
Only with step F) in the temperature handled of homogenizing change 30 ℃ into, the rotating speed of homogenizer changes 2500n/min into, the time that homogenizing is handled changes 12min into, the pH value of adjusting dispersion liquid with citric acid is 5.6, time of repose changes 70min into, obtain 1000g surgical flush fluid finished product, all the other are all with the description to embodiment 1.
Embodiment 3:
Only with steps A) in the amount of aluminium powder change 0.12g into;
Only with step B) in the amount of phosphoric acid change 0.26g into, the time of acidification changes 23min into, pH value changes 1.3 into;
Only with step C) in the amount of mannitol change 0.4g into, mixing time changes 17min into;
Only with step D) in medical gelatin change natural silk fibroin (the natural silk fibroin preferably uses the natural silk fibroin of being produced by Jiangsu Province, China Wuxi City biological product company limited) into, the amount of natural silk fibroin is 0.4g, solution temperature changes room temperature into, the time of stirring changes 7min into, this step need not to use antibacterial promptly not use hydrogen peroxide, and the suspending agent liquid that obtains is natural silk fibroin protein solution;
Only with step e) in the amount of deionized water change 968.82g into, mixing time changes 7min into, the time of continuing to stir changes 7min into;
Only with step F) in the temperature handled of homogenizing change 25 ℃ into, the rotating speed of homogenizer changes 2700n/min into, the time that homogenizing is handled changes 14min into, the pH value of adjusting dispersion liquid changes 5.7 into, time of repose changes 68min into, obtains 1000g surgical flush fluid finished product, and all the other are all with the description to embodiment 1.
Embodiment 4:
Only with steps A) in the amount of aluminium powder change 0.14g into, and change deionized water into distilled water that purity is 0.08-0.12 μ s/cm;
Only with step B) in phosphoric acid change the 0.28g citric acid of SILVER REAGENT into, the time of acidification changes 26min into, pH value changes 1.4 into;
Only with step C) in the amount of mannitol change 0.45g into, deionized water is used the distilled water that purity is 0.08-0.12 μ s/cm instead, mixing time changes 18min into;
Only with step D) in medical gelatin use embodiment 3 described natural silk fibroins instead, the amount change 0.45g into, use deionized water instead distilled water that purity is 0.08-0.12 μ s/cm, solution temperature is a room temperature, mixing time changes 10min into;
Only with step e) in deionized water use the distilled water that purity is the 968.68g of 0.08-0.12 μ s/cm instead, mixing time changes 10min into, the time of continue stirring changes 12min into;
Only with step F) in the temperature handled of homogenizing change 28 ℃ into, the rotating speed of homogenizer changes 2800n/min into, the time that homogenizing is handled changes 15min into, the pH value of adjusting dispersion liquid with citric acid is 5.8, time of repose changes 75min into, obtain 1000g surgical flush fluid finished product, all the other are all with the description to embodiment 1.
Embodiment 5:
Only with steps A) in the amount of aluminium powder change 0.16g into;
Only with step B) in phosphoric acid use the 0.30g citric acid of SILVER REAGENT instead, the time of acidification changes 28min into, pH value changes 1.5 into;
Only with step C) in the amount of mannitol change 0.5g into, mixing time changes 19min into;
Only with step D) in the amount of medical gelatin change 0.5g into, solution temperature changes 60 ℃ into, and the time of stirring and stirring then respectively changes 9min into, and the mass percent concentration of hydrogen peroxide changes 28% into, the amount of hydrogen peroxide changes 8g into, and the endotoxin inactivation processing time changes 33min into;
Only with step e) in the amount of deionized water change 960.54g into, mixing time changes 15min into, the time of continuing to stir changes 15min into;
Only with step F) in the temperature handled of homogenizing change 22 ℃ into, the rotating speed of homogenizer changes 3000n/min into, the time that homogenizing is handled changes 10min into, the pH value of adjusting dispersion liquid with phosphoric acid is pH=6, time of repose changes 80min into, obtain 1000g surgical flush fluid finished product, all the other are all with the description to embodiment 1.
The technique effect of the foregoing description 1-5 is as follows: one has adopted nanotechnology in prescription, silver is carried out nanorize to be handled, make the particle diameter of single silver element microgranule reach the 10-25nm nanoscale, give full play to silver antibacterial agent quantum effect, small-size effect, skin effect, make the surgical flush fluid of preparation have potent and long-acting sterilization bacteriostasis; They are two years old, has broad-spectrum antibacterial action, nanometer silver can kill the microorganisms such as most of antibacterials, fungus, mycete and spore that are in contact with it, verify through authoritative institutions such as U.S. FDA, Switzerland SGS laboratory and Chinese Military Medical Science Institutes, it has comprehensive antibacterial activity to drug resistance pathogenic bacteria such as drug resistance escherichia coli, drug resistance golden staphylococci, drug-resistant pseudomonas aeruginosa, micrococcus scarlatinae and anaerobe etc., and Candida albicans and chlamydia, gonococcus and fungus are also had powerful bactericidal action; They are three years old, promote healing, exchanging mechanism between nanometer silver and the zinc ion can reduce the wound surface zinc ion, promotes the release of calcium ion, increase the wound calcium ion, promote the epithelial cell regeneration of wound, have granulation promoting, convergence, promotion tissue repair and regenerated effect, quicken the recovery of wound surface and rotten to the corn face, avoid the generation of cicatrix, and reduce the sickness rate once more at this position; They are four years old, this surgical flush fluid penetration is strong, the body surface tissue has been covered with microchannel (pore, pore etc.), it is the important channel of treated in vitro, its diameter generally is micron-sized, the particle diameter of common external medicine preparation generally also is micron-sized, has skin barrier, therefore is difficult to the rapid permeability surface and arrives focus.Nanometer silver has superpower permeability, can penetrate epidermis rapidly, infiltrates subcutaneously, and common bacteria, obstinate antibacterial, drug-resistant bacteria and fungus-caused more deep tissue infection are all had good bactericidal action, the skin barrier of no common drug; Its five, surgical flush fluid of the present invention has no drug resistance, and is different with antibiotic mechanism, nanometer silver is physical property sterilization.Nanometer silver directly contacts the cell membrane sterilization of pathogenic bacteria, also can directly enter the direct killing bacteria of thalline, so pathogenic bacterium can't produce chemical sproof bacterial strain of future generation; They are six years old, surgical flush fluid safety of the present invention, nontoxic and non-stimulated, because the sterilization mechanism of nanometer silver uniqueness, chemical reaction not taking place in the sterilization process and produces other composition, after finishing sterilization process, nanometer silver is excreted by different body systemes with dead bacterium, does not form in human body and accumulates, and is safer on using.Through Academy of Military Medicine, PLA's verification experimental verification: mice is at oral maximum tolerated dose 925mg/kg, when promptly being equivalent to 4625 times of clinical use amount, do not have any toxic reaction, in the skin irritation test of rabbit, also do not find any irritant reaction.
In sum, surgical flush fluid performance of the present invention is outstanding, is the antibacterial green flushing liquor.Production technology is simple simultaneously, and not high to production environment and conditional request, the workshop that generally possesses the production disinfectant gets final product, and can adapt to the mass production requirement.
Claims (5)
1. surgical flush fluid, it is characterized in that comprising in the finished product liquor of every 1000g weight: aluminium powder 0.08-0.16g, stabilizing agent 0.3-0.5g, suspending agent 0.3-0.5g, ternary acid 0.2-0.3g and antibacterial 6-8g, surplus is a water, described aluminium powder is that purity 99.99% and particle diameter are the nano level aluminium powder of 10-25nm, described stabilizing agent is the mannitol of SILVER REAGENT, described suspending agent is medical gelatin or natural silk fibroin, described ternary acid is the phosphoric acid or the citric acid of SILVER REAGENT, described antibacterial be SILVER REAGENT and mass percent concentration be the hydrogen peroxide of 27-28%.
2. surgical flush fluid according to claim 1, the purity that it is characterized in that described water are deionized water or the distilled water of 0.08-0.12 μ s/cm.
3. the preparation method of a surgical flush fluid as claimed in claim 1 is characterized in that may further comprise the steps:
A) aluminium powder is added in the entry stir evenly, obtain argentum powder body fluid;
B) ternary acid is joined carry out acidification in the argentum powder body fluid and regulate pH value, obtain the aluminium powder mixed liquor after the acidification;
C) will join behind the stabilizing agent dilute with water in the aluminium powder mixed liquor, stir, obtain stand-by liquid;
D) elder generation is dissolved in the water suspending agent and stirs, and then adds to be used for described suspending agent is carried out the antibacterial that endotoxin inactivation is handled, and stirs then, obtains suspending agent liquid;
E) elder generation joins described stand-by liquid in the container that fills water and stirs, and adds described suspending agent liquid again and continues to stir, and obtains aluminium powder granule covering liquid;
F) the silver powder particles covering liquid is carried out homogenizing and handle, obtain dispersion liquid, the pH value with described ternary acid adjustment dispersion liquid leaves standstill, filtration and fill, obtains the finished product surgical flush fluid.
4. the preparation method of surgical flush fluid according to claim 3 is characterized in that step B) described in processing time of acidification be 18-30min, described adjusting pH value is for to be adjusted to 1-1.6 with pH value; The mixing time of the stirring step C) is 15-20min, and mixing speed is 55-65n/min; Step D) the dissolved solution temperature described in is 50-60 ℃ or room temperature, and described stirring and the time of stirring then respectively are 5-10min, and mixing speed is 55-65n/min, and the time that described endotoxin inactivation is handled is 30-35min.
5. the preparation method of surgical flush fluid according to claim 3 is characterized in that step e) described in stirring and described continuation time of stirring respectively be 5-15min, mixing speed is 55-65n/min; Step F) temperature that the homogenizing described in is handled is 20-30 ℃, the rotating speed that homogenizing is handled used homogeneous device is 2500-3000n/min, the time that homogenizing is handled is 10-16min, the pH value of described adjustment dispersion liquid is that pH value is adjusted into 5-6, the described time of repose that leaves standstill is 60-80min, the described employing strainer filtering that is filtered into, filter screen are 150 purpose filter screens.
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