CN106511478A - Compound essential oil for treating dog tinea as well as preparation method and applications of compound essential oil - Google Patents
Compound essential oil for treating dog tinea as well as preparation method and applications of compound essential oil Download PDFInfo
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- CN106511478A CN106511478A CN201611181975.4A CN201611181975A CN106511478A CN 106511478 A CN106511478 A CN 106511478A CN 201611181975 A CN201611181975 A CN 201611181975A CN 106511478 A CN106511478 A CN 106511478A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides compound essential oil for treating dog tinea. The compound essential oil is prepared from the following components in parts by weight: 1-3 parts of herba origami essential oil, 2 parts of tea tree essential oil, and 1-3 parts of rosemary essential oil. The compound essential oil is prepared by adopting herba origami essential oil, tea tree essential oil and rosemary essential oil, due to the synergistic effects of herba origami essential oil, tea tree essential oil and rosemary essential oil, a very good treatment effect is achieved on dog tinea, the effective rate is 100%, and the cure rate is 80%.
Description
Technical field
The invention belongs to veterinary drug technical field, and in particular to a kind of composite essential oil for treating dog tinea and preparation method thereof and should
With.
Background technology
Plants essential oil can be used for treatment includes cardiovascular disease, some tumors, inflammation and general disease.Plants essential oil energy
Free radical is enough removed, suppresses the peroxidation of Membrane lipids, stimulate the activity of antioxidase.The bath of plants essential oil champignon is to promoting
Physical and mental health has good effect, the Various Functions of various quintessence oils；Often bubble champignon bath being capable of blood circulation promoting, interior point of balance
Secrete, accelerate metabolism, prevent skin ageing, relieving mood, moisturizing, slimming etc..Contain in the medicine of many countries
There is plants essential oil,《American Pharmacopeia》、《British Pharmacopoeia》、《European Pharmacopoeia》、《Formulaire National》、《Deutscher Arzneibucses》、《Japanese Pharmacopoeia》
In have the related discussion of plants essential oil.Volatile oil is after refinement such as Mentholum, eucalyptus oil, Camphora, eugenol, Bulbus Allii quintessence oil
Etc. being directly used as pharmacy raw material.The pharmacology such as plants essential oil induces sweat with diverging, causing resuscitation with aromatic drugs, antibacterial, regulating QI to relieve pain, antiviral
Effect.Such as Oleum menthae dispelling-wind invigorating stomach, Chenopodium Oil anthelmintic, wintergreen oil analgesia, Oleum Bupleuri are brought down a fever.Bulbus Allii is found in recent years also
Volatility garlicin (Bulbus Allii quintessence oil) is contained within, is a kind of vegetalitas broad ectrum antibiotic.The plants essential oil of Herba Houttuyniae is clinically used
In respiratory inflammations such as treatment bronchitis, lobar pneumonia, bronchopneumonia, pulmonary abscess, gynecological is used for cervicitises, adnexa
Inflammation, reports further accordance with current research, ginseng essential oil, Rhizoma Acori Calami quintessence oil, rose pelargonium essential oil, Sarcandra glabra essential oil, Herba Pelargonii Graveolentiss quintessence oil
In citronellol and citronellyl formate have obvious curative effect to cancer.
Dermatomycosiss refer to fungal infection epidermis and its accessory structure and the dermatosis that causes, the species of pathogenic fungi
A lot.Dog fungus skin disease be parasitize it is each caused by the funguses in the quilt hair of dog and epidermis, toe pawl keratoprotein tissue
Plant dermatosiss.This is the disease that a kind of people is suffered from altogether with animal, mutually can be infected, and it is characterized in that occurring circular taking off on skin
Hair speckle, there is little tuberosity in skin, ooze out or squama, incrustation etc., animal performance pruritis.Due to causing dog dermatophytess
The cause of disease of disease is mainly Sabouraudites lanosuss, also Trichophyton mentagrophytes and Gypsum Fibrosum shape sporidiole bacteria, and the disease has a strong impact on public safety,
As the dermopathic symptom of various dogs is similar and mixed infection, diagnosis and the treatment difficulty of the disease, current chemical drugss are increased
And single quintessence oil can not effect a radical cure the disease.
The content of the invention
In order to solve problems of the prior art, the invention provides a kind of composite essential oil for treating dog tinea and its system
Preparation Method and application；With three kinds of plants essential oils as raw material, composite essential oil varnish is prepared, can preferably treat dog tinea.
First purpose of the present invention is to provide a kind of composite essential oil for treating dog tinea, and the composite essential oil is by following weight
Each material composition of part：Herba Origani Vulgaris quintessence oil 1-3 parts, 2 parts of tea tree ethereal oil, rosemary ethereal oil 1-3 parts.
Preferably, each material composition of the composite essential oil by following weight portion：3 parts of Herba Origani Vulgaris quintessence oil, tea tree ethereal oil 2
Part, 1 part of rosemary ethereal oil.
Second object of the present invention is to provide composite essential oil varnish, and its effective ingredient is answering described in claim 1 or 2
Close quintessence oil.
Third object of the present invention is to provide the preparation method of composite essential oil varnish, and step is as follows：
（1）Each material of difference precise following weight parts：10 parts of polyvinyl alcohol, 0.5 part of sodium carboxymethyl cellulose, glycerol 1
Part；
（2）Polyvinyl alcohol and sodium carboxymethyl cellulose are mixed, 5 weight portion distilled water is added and is heated to 85-87 DEG C, stirring makes
Which fully dissolves；
（3）When equitemperature is down to 30 DEG C, 0.2 weight portion of composite essential oil and glycerol, stirring and evenly mixing is added to obtain final product composite essential oil varnish.
Fourth object of the present invention is to provide above-mentioned composite essential oil or composite essential oil varnish in the medicine for preparing treatment dog tinea
Application in thing.
Containing cymene, t- terpinene, carvacrol and thymol etc., what is wherein played a major role is Adeps Bovis seu Bubali oil component
Carvacrol (carvacrol) and thymol.Research shows that Herba Origani oil has stronger antibacterial activity, and matches somebody with somebody with other quintessence oils
Close its activity and play important synergism.Tea tree ethereal oil is effective against various bacteria, and research shows, only needs tea tree ethereal oil
0.25% concentration can just suppress 90% escherichia coli, staphylococcus aureuses also to only need to 0.5%, most interestingly, even
The superbacteria developed immunity to drugs by various antibiotic：Anti- methicillinum staphylococcus aureuses, can also eliminate.
Document report rosemary ethereal oil can significantly inhibit micrococcus luteus, the growth of Escherichia coli and Bacillus subtilis, minimum inhibitor
O.5g and 0.75g amount is respectively 0.75g,.
Herba Origani oil, tea tree ethereal oil and rosemary ethereal oil are constituted composite essential oil by the present invention, and synergism between three, to dog
Tinea has good therapeutic effect, and effective percentage is 100%, and cure rate is 80%.
Specific embodiment
Below example facilitates a better understanding of the present invention, but does not limit the present invention.Experiment in following embodiments
Method, if no special instructions, is conventional method.In following embodiments, test material used, if no special instructions, is city
Sell.
1. experimental section
1.1 prescriptions are constituted：
1.2 composite essential oil extracorporeal bacteria inhibitor tests
In the quintessence oil ratio of table 1, antifungal experiment is carried out：Volatile oil ether is diluted to into different Concentraton gradient, Sharpe is put
In culture medium, 121.3 DEG C, 20 minutes autoclavings, bevel culture medium are inoculated with after 28-30 DEG C of culture observation 2 weeks, then
Normal incubation medium is inoculated in, continues culture observation 2 weeks, each strain is all provided with blank pipe.
The antifungal activity of 26 groups of quintessence oils of table
MIC represents minimal inhibitory concentration %, and MSC represents minimal bactericidal concentration %.
From table 2,2 anti-mycotic efficiency of prescription is best.Therefore be prepared according to prescription 2 below, i.e. Herba Origani Vulgaris quintessence oil, tea
The mass ratio of tree quintessence oil and rosemary ethereal oil is 3:2:1.
The preparation of 1.3 composite essential oil varnishs：
Weigh 10 parts of polyvinyl alcohol（W/W）, 0.5 part of sodium carboxymethyl cellulose（W/W）, 1 part of glycerol（W/W）；By polyvinyl alcohol and
Sodium carboxymethyl cellulose mixes, and adds 5 parts of distilled water and is heated to 87 DEG C, then mechanical agitation（600r/min）10min so as to fill
Divide dissolving, when equitemperature is down to 30 DEG C, add 0.2 part of the composite essential oil of the present invention（W/W）And glycerol, stir 10min so as to mixed
It is even to obtain final product composite essential oil varnish.
3 adjuvant of table is ratified and manufacturer
1.4 stability test
The composite essential oil varnish for preparing is taken, and 100d is stored under the conditions of room temperature (25 DEG C), as a result without lamination.
1.5 rabbit skin irritation tests
Animal packet and experiment pre-treatment：Take healthy white rabbit 16, regular grade, body weight 2.0-2.5 kg, male and female half and half,
5 d are raised before experiment and diet and behavior is observed, and if normal are randomly divided into 4 groups by sex, body weight, 4 per group.One group
Family's rabbit back spinal column both sides are cut off by front 24 h of administration by hair, are subsequently lost hair or feathers with 8% barium sulfide, and hair removal section skin is with syringe needle of sterilizing
Little " # " shape is divided into, is degree to oozing of blood, used as damaged skin group, another group is intact skin group, and two groups all set excipient control
Group.
Medication：Two groups of animals are all coated with composite essential oil varnish 2g in right side hair removal section, and left side applies excipient（Preparation side
Method ibid, does not simply add composite essential oil）About 2g is compared.Local complexity gauze and antistaling film after administration, and it is solid with adhesive plaster
It is fixed, keep medicine to contact with skin and remove after 4h gauze and antistaling film, left drug is washed away with warm water then.Administration 1 daily
It is secondary, continuous 5d.Intact skin group is in kind administered.1h and observation skin condition before being administered again after removing every time medicine.
After last dose and removal medicine, 1,24,48 and 72 h are observed again and are recorded and smear position whether there is erythema and edema and recovery
Situation, its evaluation criterion are shown in Table 4, table 5.
4 skin wound repair degree standards of grading of table
5 skin irritation intensity evaluation of table
1.6 result
Learnt by experimental administration and observation, intact skin group 1 h and again before administration and last after every time medicine is removed
1,24,48 and 72 h after administration, perusal is without the skin wound repair symptom such as obvious erythema, edema；Damaged skin group is given
After medicine, the 1st day administration side and the visible abraded area of control sides have slight redness, recover normal to the 4th day completely, thereafter often
1 h and 1,24,48 and 72 h before being administered again and after last dose after secondary removal medicine, perusal is without substantially red
The skin irritation reaction symptom such as speckle, edema, every score value are zero.
2 clinical practices
Sick dog source：20 sick dogs derive from Gansu Lintao meat dog thing feed lot.Sick dog with depilation, disconnected hair, scurf, pimple,
Vesicle, pustule, incrustation, skin lichenization symptom, Jing microscopys are defined as fungal infection.
2.1 Therapeutic Method
The cropping of sick dog affected part, removes crust, scurf, embrocates affected part with ethanol cotton and removes the dirts such as oils and fatss, and illing skin smears group
The composite essential oil varnish of side 2,2 times a day, until till sick dog gets well, regardless of curative effect, stopping after medication 1 month
Medication.
2.2 curative effect judging standard
Skin symptom disappears completely, and without gargalesthesia, microscopy funguses are negative, are healing；Skin symptom 60 more than % of disappearance, itch
Sense mitigates, and microscopy funguses are negative, are effective；Skin symptom disappearance 20%-60%, gargalesthesia mitigate, microscopy funguses
The positive, is improvement；Erythra do not disappear, aggravate or regression is less than 20%, and gargalesthesia does not change or aggravates, and microscopy funguses are positive,
For invalid.
2.3 therapeutic outcome
There are 16 sick dogs to cure, 2 sick dogs are effective, 1 sick dog takes a turn for the better.It is computed, effective percentage is 100%, cure rate is 80%.
2.4 discuss
Not only had outside the effect of good treatment dog tinea using the composite essential oil varnish of the present invention, its can also antimicrobial antiphlogistic, remove
Demodicid mite, improve immunity of organisms and promote the effects such as soft tissue healing, and it is nontoxic, noresidue, non-stimulated, transdermal characteristic is good, can penetrate
Play a role to lesions position.Its rush oozes mechanism to be dissolving skin lipid or makes skin protein degeneration, reversibly changes skin angle
The barrier of matter layer, and to cell not damaged, make antimicrobial component quickly enter skin, increase the infiltration rate of antimicrobial component, kill
Using the indeterminable funguses of other drugs.
Finally it should be noted that：The preferred embodiments of the present invention are the foregoing is only, the present invention is not limited to,
Although being described in detail to the present invention with reference to the foregoing embodiments, for a person skilled in the art, which still may be used
To modify to the technical scheme described in foregoing embodiments, or equivalent is carried out to which part technical characteristic.
All any modification, equivalent substitution and improvements within the spirit and principles in the present invention, made etc., should be included in the present invention's
Within protection domain.
Claims (5)
1. a kind of composite essential oil for treating dog tinea, it is characterised in that：Each material composition of the composite essential oil by following weight portion：
Herba Origani Vulgaris quintessence oil 1-3 parts, 2 parts of tea tree ethereal oil, rosemary ethereal oil 1-3 parts.
2. composite essential oil according to claim 1, it is characterised in that：Each material of the composite essential oil by following weight portion
Composition：3 parts of Herba Origani Vulgaris quintessence oil, 2 parts of tea tree ethereal oil, 1 part of rosemary ethereal oil.
3. composite essential oil varnish, it is characterised in that：Its effective ingredient is the composite essential oil described in claim 1 or 2.
4. the preparation method of the composite essential oil varnish described in claim 3, it is characterised in that：Step is as follows：
（1）Each material of difference precise following weight parts：10 parts of polyvinyl alcohol, 0.5 part of sodium carboxymethyl cellulose, glycerol 1
Part；
（2）Polyvinyl alcohol and sodium carboxymethyl cellulose are mixed, 5 weight portion distilled water is added and is heated to 85-87 DEG C, stirring makes
Which fully dissolves；
（3）When equitemperature is down to 30 DEG C, 0.2 weight portion of composite essential oil and glycerol, stirring and evenly mixing is added to obtain final product composite essential oil varnish.
5. composite essential oil described in claim 1 or 2, the composite essential oil varnish described in claim 3 are preparing treatment dog tinea
Application in medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611181975.4A CN106511478A (en) | 2016-12-20 | 2016-12-20 | Compound essential oil for treating dog tinea as well as preparation method and applications of compound essential oil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611181975.4A CN106511478A (en) | 2016-12-20 | 2016-12-20 | Compound essential oil for treating dog tinea as well as preparation method and applications of compound essential oil |
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| Publication Number | Publication Date |
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| CN106511478A true CN106511478A (en) | 2017-03-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201611181975.4A Pending CN106511478A (en) | 2016-12-20 | 2016-12-20 | Compound essential oil for treating dog tinea as well as preparation method and applications of compound essential oil |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375414A (en) * | 2017-06-30 | 2017-11-24 | 禹州市天源生物科技有限公司 | A kind of composite essential oil formula for treating tinea and preparation method thereof |
| CN107648084A (en) * | 2017-11-01 | 2018-02-02 | 江苏农牧科技职业学院 | A kind of plants essential oil for pet skin health care and preparation method thereof |
| CN111956566A (en) * | 2020-09-29 | 2020-11-20 | 广州弘莉生物科技有限公司 | Skin repair essential oil and method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1411857A (en) * | 2002-10-08 | 2003-04-23 | 重庆康尔威药业股份有限公司 | Tea oil ointment and suppository |
| CN105521020A (en) * | 2015-11-17 | 2016-04-27 | 安徽师范大学 | Plant extract composition having activity of controlling skin diseases in human bodies |
-
2016
- 2016-12-20 CN CN201611181975.4A patent/CN106511478A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1411857A (en) * | 2002-10-08 | 2003-04-23 | 重庆康尔威药业股份有限公司 | Tea oil ointment and suppository |
| CN105521020A (en) * | 2015-11-17 | 2016-04-27 | 安徽师范大学 | Plant extract composition having activity of controlling skin diseases in human bodies |
Non-Patent Citations (3)
| Title |
|---|
| L. MUGNAINI等: "In vitro and in vivo antifungal activity of some essential oils against feline isolates of Microsporum canis", 《MYCOLOGIE MEDICALE 》 * |
| 吴頔等: "茶树油作为天然抗菌剂的研究进展", 《中国药学杂志》 * |
| 曾月妍: "犬猫皮肤真菌病的调查与临床诊疗研究", 《CNKI优秀硕士学位论文全文库》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375414A (en) * | 2017-06-30 | 2017-11-24 | 禹州市天源生物科技有限公司 | A kind of composite essential oil formula for treating tinea and preparation method thereof |
| CN107648084A (en) * | 2017-11-01 | 2018-02-02 | 江苏农牧科技职业学院 | A kind of plants essential oil for pet skin health care and preparation method thereof |
| CN107648084B (en) * | 2017-11-01 | 2020-07-10 | 江苏农牧科技职业学院 | Plant essential oil for pet skin health care and preparation method thereof |
| CN111956566A (en) * | 2020-09-29 | 2020-11-20 | 广州弘莉生物科技有限公司 | Skin repair essential oil and method |
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Application publication date: 20170322 |