CN106727319A - A kind of gynaecology's foaming agent and preparation method thereof - Google Patents
A kind of gynaecology's foaming agent and preparation method thereof Download PDFInfo
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- CN106727319A CN106727319A CN201710014744.2A CN201710014744A CN106727319A CN 106727319 A CN106727319 A CN 106727319A CN 201710014744 A CN201710014744 A CN 201710014744A CN 106727319 A CN106727319 A CN 106727319A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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Abstract
The invention discloses a kind of gynaecology's foaming agent and preparation method thereof, it is prepared from by following raw material by weight percentage：Shitosan or chitosan derivatives 0.5 1.5%, acetic acid 0 1%, glycerine 0.5 5%, many alveolitoid surfactants 0.01 1.5%, remaining is water.The present invention is foaming agent, can make medicine in vaginal canal and skin surface is evenly distributed, and coating is wide, and foam is dense to make drug treating time more long, medicine is effectively penetrated into vagina mucosa wrinkle wall, more fully, promptly plays curative effect.Gynaecology's foaming agent foam is dense, and bactericidal effect is good, uses safety and sanitation and convenience, it is adaptable to the treatment of various vaginitis, uterine neck shield wound, wound repairing, promotion ulcer healing.
Description
Technical field
The present invention relates to a kind of foaming agent, and in particular to a kind of gynaecology's foaming agent and preparation method thereof.
Background technology
Shitosan (chitosan) is that the chitin (chitin) being widely present by nature is obtained by deacetylation
, chemical name is Chitosan (1-4) -2- amino-B-D glucose.Chitin or Chitosan-phospholipid complex are in medicine
On application it is more and more extensive, can be used as pharmaceutical carrier, such as make controlled release agent and sustained release agent so that pharmaceutical preparation is (high to " three high "
Effect, it is quick-acting, long-acting) and " three is small " (small toxicity, Small side effects, dosage is small) development, as present microencapsulated material is studied
Focus.Shitosan can obtain a series of derivative of function admirables for being adapted to different needs through structural modification.Shitosan and its spread out
Biology has preferable antibacterial activity, can suppress the growth and breeding of some fungies, bacterium and virus.It can be additionally used in Wound filling
Material, with sterilized, hemostasis, promotes the effects such as wound healing, absorption Wound exudate.
Gynaecological imflammation is a kind of common, frequently-occurring disease.At present, the anti-bacterial lotion of in the market is various in style, therapeutic domain and effect
It is really each different.The universal spirituosity of decontamination articles for use and peculiar smell that are usually used in gynaecological disease are big, stimulate skin.It is more existing on the market
Disposable washing lotion has sense of discomfort after using, and damages epidermis, often has color to be remained with smell afterwards, and washing lotion majority action times compared with
It is short.
The content of the invention
In view of the shortcomings of the prior art, first purpose of the invention is to provide a kind of gynaecology's foaming agent, and the present invention is
Foaming agent, can make medicine in vaginal canal and skin surface is evenly distributed, be coated with it is wide, foam is dense make drug treating time compared with
It is long, medicine is effectively penetrated into vagina mucosa wrinkle wall, more fully, promptly play curative effect.Gynaecology's foaming agent foam is dense,
Bactericidal effect is good, uses safety and sanitation and convenience, it is adaptable to the treatment of various vaginitis, uterine neck shield wound, and wound repairing, promotion are burst
Ulcer heals.
Second purpose of invention is to provide a kind of preparation method of gynaecology's foaming agent, its preparation process is simple, production
Equipment investment is low, obtained properties of product stabilization.
Realize that the purpose of the present invention can reach by adopting the following technical scheme that：
A kind of gynaecology's foaming agent, it is characterised in that be prepared from by following raw material by weight percentage：Shitosan or
Chitosan derivatives 0.5-1.5%, acetic acid 0-1%, glycerine 0.5-5%, many alveolitoid surfactant 0.01-1.5%, remaining is
Water.
Preferably, gynaecology's foaming agent includes following components by weight percentage：Shitosan or shitosan spread out
Biological 0.5-1.5%, acetic acid 0.1-1%, glycerine 0.5-5%, many alveolitoid surfactant 0.01-1.5%, remaining is water.
Preferably, the shitosan or chitosan derivatives are shitosan, chitosan oligosaccharide (low-molecular weight chitoglycan), shell gathering
One or more in sugared hydrochloride, chitosan quaternary ammonium salt, chitosan lactate and glutamate.
Preferably, many alveolitoid surfactants are APG, AEO, alkyl phenol polyoxy second
One or more in alkene ether, alkylolamides, tween and poloxamer.
Many alveolitoid surfactants have good permeability, are conducive to Chitosan-phospholipid complex through the cell membrane of bacterium,
So as to play synergy to sterilization.
Preferably, the water is purified water.
A kind of preparation method of gynaecology's foaming agent, it is characterised in that comprise the following steps：
A, be ready to according to formulation ratio shitosan or chitosan derivatives, acetic acid, glycerine, many alveolitoid surfactants and
Water；
B, when the addition of acetic acid is 0%, the shitosan of formula ratio or chitosan derivatives are directly added into formula ratio
Water in, stirring to dissolve, obtain mixed solution；Or, when the addition of acetic acid is more than 0%, first by the second of formula ratio
Acid is added to the water, and stirs；The shitosan or chitosan derivatives of formula ratio are subsequently adding, stirring is mixed to dissolving
Solution；
C, the glycerine for adding in mixed solution formula ratio while stirring, are well mixed；It is eventually adding many bubbles of formula ratio
Type surfactant, stirs, that is, obtain gynaecology's foaming agent.
Preferably, the shitosan or chitosan derivatives comprise the following steps by purification process：
1) weigh in the balance and take shitosan or chitosan derivatives are dissolved in acetic acid or water, stirring obtains the to after being completely dissolved
One solution；
2) the first solution is carried out into coarse filtration with stainless steel mesh, obtains the second solution；
3) the second solution is filtered by second again, obtains the 3rd solution；
4) ethanol is added while stirring, the volume ratio of ethanol and the 3rd solution is 3:1 so that shitosan or chitosan derivative
Thing precipitates, and is then centrifuged, filtered, the shitosan or chitosan derivatives for being purified；
5) shitosan or chitosan derivatives of purifying are dried, it is standby.
Preferably, step 3) in, second filtering enters horizontal high voltage suction filtration using miillpore filter.
Preferably, step 4) in, filtered after being centrifuged 30 minutes under 6000 revs/min of rotating speed.
Preferably, step 5) in, the shitosan that will be purified by baking oven or freeze dryer is under 40-60 DEG C of temperature conditionss
It is dried, dries to constant weight.
The beneficial effects of the present invention are：
1st, after the present invention has added many alveolitoid nonionic surfactants, can make medicine in vaginal canal and skin surface distribution
Uniformly, coating is wide, and foam is dense to make drug treating time more long, medicine is effectively penetrated into vagina mucosa wrinkle wall, more fills
Divide, promptly play curative effect.Many alveolitoid nonionic surfactants can also strengthen the bactericidal property of Chitosan-phospholipid complex.
Gynaecology's foaming agent foam is dense, and bactericidal effect is good, uses safety and sanitation and convenience, it is adaptable to the treatment of various vaginitis, palace
Neck shield wound, wound repairing, promotion ulcer healing.
2nd, got because shitosan raw material is mainly from shrimp crab shell extraction, the generation of impurity is had in extraction process.
Ash content and content of beary metal are shitosan raw material two and its important index, directly affect the security of product, are easily caused skin
Skin stimulates or sees through presses exceeded.Chitosan-phospholipid complex have passed through purification process by the present invention, improve purity, and impurity level subtracts
Few, biocompatibility more preferably, reduces adverse reaction.After raw material carries out purification process, content of beary metal and ash content have all declined,
Make the solution efficacy allotted more preferably, biocompatibility is improved, reduce adverse reaction.
3rd, preparation process is simple of the invention, investment of production equipment is low, obtained properties of product stabilization.
Specific embodiment
Below, with reference to specific embodiment, the present invention is described further：
Embodiment 1：
A kind of gynaecology's foaming agent, is prepared from by following raw material by weight percentage：Shitosan 1.0%, acetic acid
1%, glycerine 0.5%, AEO 0.01%, alkylolamides 1.5%, remaining is purified water.
The shitosan comprises the following steps by purification process：
1) weigh that to take shitosan soluble in water in the balance, stirring obtains the first solution to after being completely dissolved；
2) the first solution is carried out into coarse filtration with stainless steel mesh, obtains the second solution；
3) the second solution is filtered by second again, obtains the 3rd solution；Second filtering is carried out using miillpore filter
High pressure suction filtration.
4) ethanol is added to cause that shitosan precipitates while stirring, the volume ratio of ethanol and the 3rd solution is 3:1；Then
Filtered after being centrifuged 30 minutes under 6000 revs/min of rotating speed, the shitosan for being purified；
5) shitosan of purifying is dried under 50 DEG C of temperature conditionss by baking oven or freeze dryer, is dried to perseverance
Weight, it is standby.
A kind of preparation method of gynaecology's foaming agent, it is characterised in that comprise the following steps：
A, shitosan, acetic acid, glycerine, many alveolitoid surfactants and water are got out according to formulation ratio；
B, when the addition of acetic acid is 0%, the shitosan of formula ratio is directly added into the water of formula ratio, stirring is to molten
Solution, obtains mixed solution；Or, when the addition of acetic acid is more than 0%, first the acetic acid of formula ratio is added to the water, stir
Uniformly；The shitosan of formula ratio is subsequently adding, stirring obtains mixed solution to dissolving；
C, the glycerine for adding in mixed solution formula ratio while stirring, are well mixed；It is eventually adding the fat of formula ratio
Alcohol APEO, alkylolamides, stir, that is, obtain gynaecology's foaming agent.
The contrast of the content of beary metal, ash content of the shitosan after before purification, (presses YY/T0606.7-2008 organizational projects doctor
The part shitosan 7.6 and 7.10 of product the 7th is treated to be detected) result such as table 1.
Table 1
| It is required that | Before purification | After purification | |
| Content of beary metal | ≤10μg/g | <10μg/g | <5μg/g |
| Ash content | ≤ 0.5% | 0.40% | 0.25% |
The foam time of gynaecology's foaming agent：
Take under one bottle of foaming agent pressing 1, foam is sprayed in the graduated cylinder of 50ml, stand and read foam height, calculate foam
The required time is completely eliminated, 2 are the results are shown in Table.
Table 2
| Foam height | Time required for eliminating |
| 10ml | 8min |
Bactericidal property before and after many alveolitoid surfactants are added is contrasted (by the regulation of C3 in GB 15979-2002 appendix Cs
Carry out, sterilizing time：3min；BA evaluation criterion：Sterilizing rate：More than or equal to 90%, product has bactericidal action), as a result
It is shown in Table 3.
Table 3
Embodiment 2：
A kind of gynaecology's foaming agent, is prepared from by following raw material by weight percentage：Chitosan oligosaccharide 1.5%, acetic acid
0%, glycerine 5%, APG 1.2%, remaining is purified water.
The chitosan oligosaccharide comprises the following steps by purification process：
1) weigh that to take chitosan oligosaccharide soluble in water in the balance, stirring obtains the first solution to after being completely dissolved；
2) the first solution is carried out into coarse filtration with stainless steel mesh, obtains the second solution；
3) the second solution is filtered by second again, obtains the 3rd solution；Second filtering is carried out using miillpore filter
High pressure suction filtration.
4) ethanol is added to cause that chitosan oligosaccharide precipitates while stirring, the volume ratio of ethanol and the 3rd solution is 3:1；Then
Filtered after being centrifuged 30 minutes under 6000 revs/min of rotating speed, the chitosan oligosaccharide for being purified；
5) chitosan oligosaccharide of purifying is dried under 40 DEG C of temperature conditionss by baking oven or freeze dryer, is dried to perseverance
Weight, it is standby.
A kind of preparation method of gynaecology's foaming agent, it is characterised in that comprise the following steps：
A, chitosan oligosaccharide, acetic acid, glycerine, many alveolitoid surfactants and water are got out according to formulation ratio；
B, when the addition of acetic acid is 0%, the chitosan oligosaccharide of formula ratio is directly added into the water of formula ratio, stirring is to molten
Solution, obtains mixed solution；
C, the glycerine for adding in mixed solution formula ratio while stirring, are well mixed；It is eventually adding the alkyl of formula ratio
Glucosides, stirs, that is, obtain gynaecology's foaming agent.
The contrast of the content of beary metal, ash content of the chitosan oligosaccharide after before purification, the results are shown in Table 4.
Table 4
| It is required that | Before purification | After purification | |
| Content of beary metal | ≤10μg/g | <10μg/g | <5μg/g |
| Ash content | ≤ 0.5% | 0.36% | 0.21% |
The foam time of gynaecology's foaming agent：
Take under one bottle of foaming agent pressing 1, foam is sprayed in the graduated cylinder of 50ml, stand and read foam height, calculate foam
The required time is completely eliminated, 5 are the results are shown in Table.
Table 5
| Foam height | Time required for eliminating |
| 15ml | 12min |
Bactericidal property before and after many alveolitoid surfactants are added is contrasted (by the regulation of C3 in GB 15979-2002 appendix Cs
Carry out, sterilizing time：3min；BA evaluation criterion：Sterilizing rate：More than or equal to 90%, product has bactericidal action), as a result
It is shown in Table 6.
Table 6
Embodiment 3：
A kind of gynaecology's foaming agent, is prepared from by following raw material by weight percentage：Chitosan quaternary ammonium salt 0.5%,
Acetic acid 0%, glycerine 2%, APG 0.5%, tween 0.01% is constituted, and remaining is purified water.
Chitosan quaternary ammonium salt comprises the following steps by purification process：
1) weigh that to take chitosan quaternary ammonium salt soluble in water in the balance, stirring obtains the first solution to after being completely dissolved；
2) the first solution is carried out into coarse filtration with stainless steel mesh, obtains the second solution；
3) the second solution is filtered by second again, obtains the 3rd solution；Second filtering is carried out using miillpore filter
High pressure suction filtration.
4) ethanol is added to cause that chitosan quaternary ammonium salt precipitates while stirring, the volume ratio of ethanol and the 3rd solution is 3:
1；Then filtered after being centrifuged 30 minutes under 6000 revs/min of rotating speed, the chitosan quaternary ammonium salt for being purified；
5) chitosan quaternary ammonium salt of purifying is dried under 60 DEG C of temperature conditionss by baking oven or freeze dryer, is dried
It is standby to constant weight.
A kind of preparation method of gynaecology's foaming agent, comprises the following steps：
A, chitosan quaternary ammonium salt, acetic acid, glycerine, APG, tween are got out according to formulation ratio, remaining is purifying
Water；
B, when the addition of acetic acid is 0%, the chitosan quaternary ammonium salt of formula ratio is directly added the purified water of formula ratio
In, stirring obtains mixed solution to dissolving；
C, the glycerine for adding in mixed solution formula ratio while stirring, are well mixed；It is eventually adding the alkyl of formula ratio
Glucosides, tween, stir, that is, obtain gynaecology's foaming agent.
The contrast of the content of beary metal, ash content of the chitosan quaternary ammonium salt after before purification, the results are shown in Table 7.
Table 7
| It is required that | Before purification | After purification | |
| Content of beary metal | ≤10μg/g | <10μg/g | <5μg/g |
| Ash content | ≤ 0.5% | 0.36% | 0.20% |
The foam time of gynaecology's foaming agent：
Take under one bottle of foaming agent pressing 1, foam is sprayed in the graduated cylinder of 50ml, stand and read foam height, calculate foam
The required time is completely eliminated, 8 are the results are shown in Table.
Table 8
| Foam height | Time required for eliminating |
| 18ml | 15min |
Bactericidal property before and after many alveolitoid surfactants are added is contrasted (by the regulation of C3 in GB 15979-2002 appendix Cs
Carry out, sterilizing time：3min；BA evaluation criterion：Sterilizing rate：More than or equal to 90%, product has bactericidal action), as a result
It is shown in Table 9.
Table 9
Embodiment 4：
The characteristics of the present embodiment is：A kind of gynaecology's foaming agent, is prepared from by following raw material by weight percentage：Shell
Glycan 0.8%, acetic acid 0.1%, glycerine 0.5%, AEO 0.01%, alkylolamides 1.5%, remaining is pure
Change water.Other are same as Example 1.
The contrast of the content of beary metal, ash content of the shitosan after before purification, the results are shown in Table 10.
Table 10
| It is required that | Before purification | After purification | |
| Content of beary metal | ≤10μg/g | <10μg/g | <6μg/g |
| Ash content | ≤ 0.5% | 0.36% | 0.28% |
The foam time of gynaecology's foaming agent：
Take under one bottle of foaming agent pressing 1, foam is sprayed in the graduated cylinder of 50ml, stand and read foam height, calculate foam
The required time is completely eliminated, 11 are the results are shown in Table.
Table 11
| Foam height | Time required for eliminating |
| 12ml | 13min |
Bactericidal property before and after many alveolitoid surfactants are added is contrasted (by the regulation of C3 in GB 15979-2002 appendix Cs
Carry out, sterilizing time：3min；BA evaluation criterion：Sterilizing rate：More than or equal to 90%, product has bactericidal action), as a result
It is shown in Table 12.
Table 12
The foam that can be seen that gynaecology's foaming agent by the table 2 of embodiment 1-4, table 5, table 8, table 11 is dense, foam duration
Time more than 8 minutes, wherein, sustainable 15 minutes of the foam time of embodiment 3.By the table 3 of embodiment 1-4, table 6, table 9,
Table 12 is as can be seen that many alveolitoid surfactants enhance the bactericidal properties of shitosan or chitosan derivatives, gynaecology's foaming agent
Sterilizing rate for staphylococcus aureus, Escherichia coli and Candida albicans is all higher than 90%, with preferable bactericidal effect,
Wherein, the bactericidal effect of embodiment 3 is optimal.
For a person skilled in the art, technical scheme that can be as described above and design, make other each
Plant corresponding change and deform, and all these changes and deforms the protection model that should all belong to the claims in the present invention
Within enclosing.
Claims (10)
1. a kind of gynaecology's foaming agent, it is characterised in that be prepared from by following raw material by weight percentage：Shitosan or shell
Polysaccharid derivative 0.5-1.5%, acetic acid 0-1%, glycerine 0.5-5%, many alveolitoid surfactant 0.01-1.5%, remaining is
Water.
2. gynaecology's foaming agent according to claim 1, it is characterised in that including following components by weight percentage：
Shitosan or chitosan derivatives 0.5-1.5%, acetic acid 0.1-1%, glycerine 0.5-5%, many alveolitoid surfactant 0.01-
1.5%, remaining is water.
3. gynaecology's foaming agent according to claim 1, it is characterised in that the shitosan or chitosan derivatives are poly- for shell
One kind in sugar, chitosan oligosaccharide, chitosan hydrochloride, chitosan quaternary ammonium salt, chitosan lactate and glutamate or two
More than kind.
4. gynaecology's foaming agent according to claim 1, it is characterised in that many alveolitoid surfactants are alkyl sugar
One or two in glycosides, AEO, APES, alkylolamides, tween and poloxamer
More than.
5. gynaecology's foaming agent according to claim 1, it is characterised in that the water is purified water.
6. a kind of preparation method of gynaecology's foaming agent according to claim 1-5 any one, it is characterised in that including following
Step：
A, shitosan or chitosan derivatives, acetic acid, glycerine, many alveolitoid surfactants and water are got out according to formulation ratio；
B, when the addition of acetic acid is 0%, the shitosan of formula ratio or chitosan derivatives are directly added the water of formula ratio
In, stirring obtains mixed solution to dissolving；Or, when the addition of acetic acid is more than 0%, first the acetic acid of formula ratio is added
Enter in water, stir；The shitosan or chitosan derivatives of formula ratio are subsequently adding, stirring obtains mixed solution to dissolving；
C, the glycerine for adding in mixed solution formula ratio while stirring, are well mixed；It is eventually adding many alveolitoid tables of formula ratio
Face activating agent, stirs, that is, obtain gynaecology's foaming agent.
7. the preparation method of gynaecology's foaming agent according to claim 6, it is characterised in that the shitosan or shitosan spread out
Biology comprises the following steps by purification process：
1) weigh in the balance and take shitosan or chitosan derivatives are dissolved in acetic acid or water, it is molten that stirring obtains first to after being completely dissolved
Liquid；
2) the first solution is carried out into coarse filtration with stainless steel mesh, obtains the second solution；
3) the second solution is filtered by second again, obtains the 3rd solution；
4) ethanol is added while stirring, the volume ratio of ethanol and the 3rd solution is 3:1 so that shitosan or chitosan derivatives are heavy
Shallow lake is got off, and is then centrifuged, filtered, the shitosan or chitosan derivatives for being purified；
5) shitosan or chitosan derivatives of purifying are dried, it is standby.
8. the preparation method of gynaecology's foaming agent according to claim 7, it is characterised in that step 3) in, filter for second
Horizontal high voltage suction filtration is entered using miillpore filter.
9. the preparation method of gynaecology's foaming agent according to claim 7, it is characterised in that step 4) in, at 6000 revs/min
Filtered after being centrifuged 30 minutes under the rotating speed of clock.
10. the preparation method of gynaecology's foaming agent according to claim 7, it is characterised in that step 5) in, by baking oven or
Under 40-60 DEG C of temperature conditionss be dried the shitosan of purifying by freeze dryer, dries to constant weight.
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| CN108158995A (en) * | 2017-12-29 | 2018-06-15 | 广州润虹医药科技股份有限公司 | A kind of gynaecology's anti-bacteria foaming agent containing chitosan and preparation method thereof |
| CN109316444A (en) * | 2018-11-09 | 2019-02-12 | 南京道大药业有限公司 | A kind of antibacterial chitose foaming agent and preparation method thereof |
| CN109568647A (en) * | 2017-09-28 | 2019-04-05 | 上海君联医疗设备有限公司 | Foam type chitosan liquid film and preparation method thereof |
| CN114366816A (en) * | 2022-01-05 | 2022-04-19 | 重庆福美干细胞生物科技发展有限公司 | Chitosan nanoparticles with excellent freeze-drying redispersibility, freeze-drying preparation, and preparation method and application thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109568647A (en) * | 2017-09-28 | 2019-04-05 | 上海君联医疗设备有限公司 | Foam type chitosan liquid film and preparation method thereof |
| CN108079165A (en) * | 2017-12-29 | 2018-05-29 | 广州润虹医药科技股份有限公司 | A kind of gynaecology's washing lotion containing chitosan quaternary ammonium salt and preparation method thereof |
| CN108158995A (en) * | 2017-12-29 | 2018-06-15 | 广州润虹医药科技股份有限公司 | A kind of gynaecology's anti-bacteria foaming agent containing chitosan and preparation method thereof |
| CN109316444A (en) * | 2018-11-09 | 2019-02-12 | 南京道大药业有限公司 | A kind of antibacterial chitose foaming agent and preparation method thereof |
| CN114366816A (en) * | 2022-01-05 | 2022-04-19 | 重庆福美干细胞生物科技发展有限公司 | Chitosan nanoparticles with excellent freeze-drying redispersibility, freeze-drying preparation, and preparation method and application thereof |
| CN114366816B (en) * | 2022-01-05 | 2023-06-20 | 重庆福美干细胞生物科技发展有限公司 | Chitosan nanoparticle with excellent freeze-drying redispersibility, freeze-drying preparation, and preparation method and application thereof |
| CN117482105A (en) * | 2023-11-08 | 2024-02-02 | 通山县人民医院 | Chitosan-based slow-release gynecological antibacterial liquid and preparation method thereof |
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