CN107400579A - A kind of gynaecology's handmade soap and preparation method thereof - Google Patents
A kind of gynaecology's handmade soap and preparation method thereof Download PDFInfo
- Publication number
- CN107400579A CN107400579A CN201710557891.4A CN201710557891A CN107400579A CN 107400579 A CN107400579 A CN 107400579A CN 201710557891 A CN201710557891 A CN 201710557891A CN 107400579 A CN107400579 A CN 107400579A
- Authority
- CN
- China
- Prior art keywords
- parts
- gynaecology
- handmade soap
- filler
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000344 soap Substances 0.000 title claims abstract description 76
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 42
- 239000002893 slag Substances 0.000 claims abstract description 39
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000000945 filler Substances 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 235000011187 glycerol Nutrition 0.000 claims abstract description 15
- FCBUKWWQSZQDDI-UHFFFAOYSA-N rhamnolipid Chemical compound CCCCCCCC(CC(O)=O)OC(=O)CC(CCCCCCC)OC1OC(C)C(O)C(O)C1OC1C(O)C(O)C(O)C(C)O1 FCBUKWWQSZQDDI-UHFFFAOYSA-N 0.000 claims abstract description 15
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 14
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 14
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 claims abstract description 14
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 claims abstract description 14
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 14
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 14
- 239000011734 sodium Substances 0.000 claims abstract description 14
- 239000008117 stearic acid Substances 0.000 claims abstract description 14
- 239000003240 coconut oil Substances 0.000 claims abstract description 13
- 235000019864 coconut oil Nutrition 0.000 claims abstract description 13
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims abstract description 12
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims abstract description 12
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims abstract description 12
- 229940045870 sodium palmitate Drugs 0.000 claims abstract description 12
- GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 claims abstract description 12
- 235000010894 Artemisia argyi Nutrition 0.000 claims description 27
- 244000030166 artemisia Species 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 22
- PCWPQSDFNIFUPO-VDQKLNDWSA-N (1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37S,38R,39S,40R,41S,42R,43S,44R,45S,46R,47S,48R,49S)-37,39,41,43,45,47,49-heptakis(2-hydroxyethoxy)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,38,40,42,44,46,48-heptol Chemical compound OCCO[C@H]1[C@H](O)[C@@H]2O[C@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@H](CO)[C@@H](O[C@H]5O[C@H](CO)[C@@H](O[C@H]6O[C@H](CO)[C@@H](O[C@H]7O[C@H](CO)[C@@H](O[C@H]8O[C@H](CO)[C@@H](O[C@H]1O[C@@H]2CO)[C@@H](O)[C@@H]8OCCO)[C@@H](O)[C@@H]7OCCO)[C@@H](O)[C@@H]6OCCO)[C@@H](O)[C@@H]5OCCO)[C@@H](O)[C@@H]4OCCO)[C@@H](O)[C@@H]3OCCO PCWPQSDFNIFUPO-VDQKLNDWSA-N 0.000 claims description 9
- 241000894006 Bacteria Species 0.000 claims description 9
- 229910021538 borax Inorganic materials 0.000 claims description 9
- 238000000855 fermentation Methods 0.000 claims description 9
- 230000004151 fermentation Effects 0.000 claims description 9
- 229920000609 methyl cellulose Polymers 0.000 claims description 9
- 239000001923 methylcellulose Substances 0.000 claims description 9
- 239000004328 sodium tetraborate Substances 0.000 claims description 9
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 2
- 235000013162 Cocos nucifera Nutrition 0.000 claims description 2
- 244000060011 Cocos nucifera Species 0.000 claims description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 2
- 239000005642 Oleic acid Substances 0.000 claims description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 8
- 210000001215 vagina Anatomy 0.000 abstract description 7
- 238000004140 cleaning Methods 0.000 abstract description 6
- 230000001954 sterilising effect Effects 0.000 abstract description 5
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 5
- 230000001012 protector Effects 0.000 abstract description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- WXBXVVIUZANZAU-CMDGGOBGSA-N trans-2-decenoic acid Chemical compound CCCCCCC\C=C\C(O)=O WXBXVVIUZANZAU-CMDGGOBGSA-N 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 36
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 20
- 238000012360 testing method Methods 0.000 description 20
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 18
- 230000001139 anti-pruritic effect Effects 0.000 description 10
- 241000235342 Saccharomycetes Species 0.000 description 8
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 230000008961 swelling Effects 0.000 description 8
- 208000003251 Pruritus Diseases 0.000 description 7
- 239000003908 antipruritic agent Substances 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 4
- 230000001408 fungistatic effect Effects 0.000 description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 210000005069 ears Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229960001660 histamine phosphate Drugs 0.000 description 3
- ZHIBQGJKHVBLJJ-UHFFFAOYSA-N histamine phosphate Chemical compound OP(O)(O)=O.OP(O)(O)=O.NCCC1=CNC=N1 ZHIBQGJKHVBLJJ-UHFFFAOYSA-N 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000001953 sensory effect Effects 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 240000006409 Acacia auriculiformis Species 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 235000021314 Palmitic acid Nutrition 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 244000178320 Vaccaria pyramidata Species 0.000 description 2
- 235000010587 Vaccaria pyramidata Nutrition 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000003266 anti-allergic effect Effects 0.000 description 2
- 230000001741 anti-phlogistic effect Effects 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 238000005238 degreasing Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
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- 210000000952 spleen Anatomy 0.000 description 2
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- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 244000301850 Cupressus sempervirens Species 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241001360526 Escherichia coli ATCC 25922 Species 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 241000830535 Ligustrum lucidum Species 0.000 description 1
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 244000234609 Portulaca oleracea Species 0.000 description 1
- 235000001855 Portulaca oleracea Nutrition 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- 241001671204 Stemona Species 0.000 description 1
- 241000224527 Trichomonas vaginalis Species 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000035617 depilation Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
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- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 229940072033 potash Drugs 0.000 description 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
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- 230000001105 regulatory effect Effects 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 238000009781 safety test method Methods 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
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- 230000002618 waking effect Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/02—Compositions of detergents based essentially on soap on alkali or ammonium soaps
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/06—Inorganic compounds
- C11D9/18—Water-insoluble compounds
- C11D9/20—Fillers, abrasives
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/225—Polymers
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/26—Organic compounds, e.g. vitamins containing oxygen
- C11D9/262—Organic compounds, e.g. vitamins containing oxygen containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/26—Organic compounds, e.g. vitamins containing oxygen
- C11D9/265—Organic compounds, e.g. vitamins containing oxygen containing glycerol
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/26—Organic compounds, e.g. vitamins containing oxygen
- C11D9/267—Organic compounds, e.g. vitamins containing oxygen containing free fatty acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/30—Organic compounds, e.g. vitamins containing nitrogen
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/34—Organic compounds, e.g. vitamins containing phosphorus
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/38—Products in which the composition is not well defined
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Abstract
The invention belongs to commodity to wash protector for collar domain, and in particular to a kind of gynaecology's handmade soap and preparation method thereof.The invention provides a kind of gynaecology's handmade soap, including following components and its parts by weight：End 40 50 parts of 15 parts of slag tunning, 0.5 1.5 parts of 10 hydroxyl, 2 decylenic acid, 0.1 0.5 parts of chitosan oligosaccharide, 48 parts of rhamnolipid, 20 30 parts of sodium palmitate, 10 20 parts of coconut oil sodium, 5 15 parts of stearic acid, 11 parts of phosphatidase 5,6 12 parts of glycerine, 15 parts of ethanol, 0.005 0.015 parts of menthyl lactate, 0.3 0.7 parts of citric acid, 0.1 0.5 parts of disodium ethylene diamine tetraacetate, 15 35 parts of filler and water.Gynaecology's handmade soap provided by the invention is gently non-stimulated, has the function that good cleaning, sterilization, anti-inflammatory to women privates, can effectively maintain vagina normal ph and wettability.
Description
Technical field
The invention belongs to commodity to wash protector for collar domain, and in particular to a kind of gynaecology's handmade soap and preparation method thereof.
Background technology
Bacterial infection disease is most commonly seen in clinical position, the use of antibiotic therapy bacterial infection disease has been most
One of universal treatment method.In recent years, because the mankind are for the abuse of antibiotic, bacterium to the drug resistances of each antibiotics,
Rapid increase trend is presented in the resistance to the action of a drug, persister always, or even produces the situation that " strength bacterium " pasts medical help, and medicine
Toxic side effect also increases as.Female organism easily causes women to infect various bacteriums, true due to relatively special physiological structure
Bacterium etc. is so as to inducing a series of diseases such as genital system infection.Perfumed soap common at present is all with by palm oil, coconut oil or dynamic
The soap base that thing grease obtains after sodium hydroxide saponification is made up of raw material, and its degreasing dynamics is strong, and alkalescence is strong, the stimulation to skin
Property it is very big, therefore be often suitable only for being used to take a shower, and be not suitable for women privates washing shield.
Chinese mugwort slag is the dregs of a decoction after folium artemisiae argyi extraction.Folium artemisiae argyi is parts of generic medicinal plants, has eliminating cold to stop pain, warming channel for arresting bleeding, menstruation regulating peace
Tire, removing dampness to relieve itching and clearing and activating the channels and collaterals and other effects.The traditional Chinese medical science takes folium artemisiae argyi to be used as medicine, Return liver, spleen, kidney channel, and acrid flavour is bitter, warm-natured, have antibacterial,
The functions such as antiviral, antiallergy, eliminating cold to stop pain, warming channel for arresting bleeding.Existing Folium Artemisiae Argyi extract consumption increasingly increases, and Chinese mugwort slag also increases therewith
It is more.However, in real life, people typically can directly discard Chinese mugwort slag, and the utilization to the slag that ends is less.
Chinese patent application CN105695172A discloses a kind of nursing soap for ladies only, by the raw material of following parts by weight
Composition：Glycerine 5-10 parts, cocounut oil 8-15 parts, rhamnose 3-5 parts, natural oil 5-10 parts, citric acid 2-5 parts, potash soap 20-40
Part, sodium chloride 5-10 parts, vitamin E 4-8 parts, 20 parts of water, frutus cnidii 2-3 parts, rhizome of chuanxiong 3-5 parts, fruit of glossy privet 2-4 parts, golden cypress 3-
5 parts, tuber of stemona 2-4 parts, folium artemisiae argyi 3-5 parts, kuh-seng 3-5 parts, purslane 2-4 parts, although the nursing soap is good to having at Ms's secret
Good cleaning, sterilization and fungistatic effect, but it is easily destroyed vagina acid-base degree.
Chinese patent application CN106753920A discloses a kind of privates perfumed soap for preventing senile vahinitis, the perfumed soap
Include the raw material of following mass percent meter：Lactic acid bacteria powder 0.01-0.1%, Chinese medicine composition 0.1-0.5%, grease 55-
70%, sodium hydroxide 1-5%, surplus is deionized water.The perfumed soap of the invention can prevent senile vahinitis, but long-term use of
Vagina acid-base degree balance can be destroyed.
Therefore, develop a kind of antibacterial, anti-inflammatory, antipruritic, excitant is small, can effectively maintain the gynaecology of vagina normal ph manual
Soap has strong realistic meaning.
The content of the invention
In order to solve problems of the prior art, it is an object of the invention to provide a kind of gynaecology's handmade soap and its system
Preparation Method.Gynaecology's handmade soap provided by the invention is gently non-stimulated, has to women privates good cleaning, sterilization, anti-inflammatory
Effect, can effectively maintain vagina normal ph and wettability.
The invention provides a kind of gynaecology's handmade soap, including following components and its parts by weight：
End slag tunning 1-5 parts, 10-HAD 0.5-1.5 parts, chitosan oligosaccharide 0.1-0.5 parts, rhamnolipid
4-8 parts, sodium palmitate 20-30 parts, coconut oil sodium 10-20 parts, stearic acid 5-15 parts, -11 parts of phosphatidase 5, glycerine 6-12 parts, ethanol
1-5 parts, menthyl lactate 0.005-0.015 parts, citric acid 0.3-0.7 parts, disodium ethylene diamine tetraacetate 0.1-0.5 parts, filling
Agent 15-35 parts and water 40-50 parts.Chitosan oligosaccharide is purchased from Guangzhou Ka Fen bio tech ltd；Rhamnolipid is purchased from Hubei auspicious the present
Chemical Co., Ltd.；Coconut oil sodium CAS：61789-31-9；Phosphatide is purchased from Ningbo Dahongying Bio-engineering Co., Ltd..
Further, described gynaecology's handmade soap is made up of following components and its parts by weight：
End 3 parts of slag tunning, 1 part of 10-HAD, 0.3 part of chitosan oligosaccharide, 6 parts of rhamnolipid, sodium palmitate
25 parts, 15 parts of coconut oil sodium, 10 parts of stearic acid, 8 parts of phosphatide, 9 parts of glycerine, 3 parts of ethanol, 0.01 part of menthyl lactate, citric acid
45 parts of 0.5 part, 0.3 part of disodium ethylene diamine tetraacetate, 25 parts of filler and water.
Further, the Chinese mugwort slag tunning is Chinese mugwort slag products therefrom after saccharomycetes to make fermentation.
Further, the filler is hydroxyethyl-β-cyclodextrin, methylcellulose and borax by weight 2:5:1 group
Into.
Meanwhile present invention provides a kind of preparation method of gynaecology's handmade soap, comprise the following steps：
S1 adds Chinese mugwort slag tunning, 10-HAD and menthyl lactate into ethanol, stirring to dissolving,
Obtain solution A；
Disodium ethylene diamine tetraacetate is added to the water by S2, is heated to 70-80 DEG C, stirring added to after dissolving sodium palmitate,
Cocinic acid, stearic acid, phosphatide and glycerine, 20-40min is stirred, obtains mixture B；
Mixture B obtained by step S2 is cooled to 40-50 DEG C by S3, stirring add step S1 resulting solutions A, rhamnolipid,
Chitosan oligosaccharide and citric acid, 30-40min is stirred, obtains mixture C；
Mixture C obtained by step S3 is cooled to 30-40 DEG C by S4, adds filler, is stirred 5-15min, is poured into mould, wind
It is dry, produce.
Further, heating-up temperature is 75 DEG C in the step S2, mixing time 30min.
Further, chilling temperature is 45 DEG C in the step S3, mixing time 35min.
Further, chilling temperature is 35 DEG C in the step S4, mixing time 10min.
Folium artemisiae argyi Return liver, spleen, kidney channel, acrid flavour is bitter, warm-natured, has antibacterial, antiviral, antiallergy, eliminating cold to stop pain, warming channel for arresting bleeding
Etc. function.Inventor has carried out numerous studies to Chinese mugwort slag, find Chinese mugwort slag after saccharomycetes to make fermentation products therefrom to Candida albicans,
Trichomonas vaginalis, Escherichia coli, staphylococcus aureus etc. have obvious inhibitory action.But should by Chinese mugwort slag tunning
Using but causes the reduction of its bacteriostasis in handmade soap, inventor is studied by lot of experiments, is prepared for a kind of weakly acidic hand
Work soap, pH have effectively played sterilization, the bacteriostasis of Chinese mugwort slag tunning between 4.0-5.0.
Compared with prior art, gynaecology's handmade soap provided by the invention is gently non-stimulated, has well to women privates
Cleaning, sterilization, anti-inflammatory, antipruritic effect, vagina normal ph and wettability can be effectively maintained, effectively alleviates gynaecological imflammation；Together
When, The invention also achieves the utilization once again of Chinese mugwort slag resource, avoid the waste of resource.
Embodiment
The present invention is described in further details below by specific embodiment, these embodiments are only used for the mesh of illustration
, it is in no way intended to limit protection scope of the present invention.
A kind of gynaecology's handmade soap of embodiment 1
Gynaecology's handmade soap is made up of following components and its parts by weight：
End 1 part of slag tunning, 0.5 part of 10-HAD, 0.1 part of chitosan oligosaccharide, 4 parts of rhamnolipid, palmitic acid
20 parts of sodium, 10 parts of coconut oil sodium, 5 parts of stearic acid, phosphatidase 5 part, 6 parts of glycerine, 1 part of ethanol, 0.005 part of menthyl lactate, lemon
50 parts of 0.3 part of acid, 0.1 part of disodium ethylene diamine tetraacetate, 15 parts of filler and water.
The Chinese mugwort slag tunning is Chinese mugwort slag products therefrom after saccharomycetes to make fermentation.
The filler is hydroxyethyl-β-cyclodextrin, methylcellulose and borax by weight 2:5:1 composition.
Preparation method：
S1 adds Chinese mugwort slag tunning, 10-HAD and menthyl lactate into ethanol, stirring to dissolving,
Obtain solution A；
Disodium ethylene diamine tetraacetate is added to the water by S2, is heated to 75 DEG C, stirring adds sodium palmitate, coconut to after dissolving
Oleic acid, stearic acid, phosphatide and glycerine, 30min is stirred, obtains mixture B；
Mixture B obtained by step S2 is cooled to 40-50 DEG C by S3, stirring add step S1 resulting solutions A, rhamnolipid,
Chitosan oligosaccharide and citric acid, 35min is stirred, obtains mixture C；
Mixture C obtained by step S3 is cooled to 35 DEG C by S4, adds filler, is stirred 10min, is poured into mould, is air-dried, i.e.,
.
A kind of gynaecology's handmade soap of embodiment 2
Gynaecology's handmade soap is made up of following components and its parts by weight：
End 3 parts of slag tunning, 1 part of 10-HAD, 0.3 part of chitosan oligosaccharide, 6 parts of rhamnolipid, sodium palmitate
25 parts, 15 parts of coconut oil sodium, 10 parts of stearic acid, 8 parts of phosphatide, 9 parts of glycerine, 3 parts of ethanol, 0.01 part of menthyl lactate, citric acid
45 parts of 0.5 part, 0.3 part of disodium ethylene diamine tetraacetate, 25 parts of filler and water.
The Chinese mugwort slag tunning is Chinese mugwort slag products therefrom after saccharomycetes to make fermentation.
The filler is hydroxyethyl-β-cyclodextrin, methylcellulose and borax by weight 2:5:1 composition.
Preparation method is similar to Example 1.
A kind of gynaecology's handmade soap of embodiment 3
Gynaecology's handmade soap is made up of following components and its parts by weight：
End 5 parts of slag tunning, 1.5 parts of 10-HAD, 0.5 part of chitosan oligosaccharide, 8 parts of rhamnolipid, palmitic acid
30 parts of sodium, 20 parts of coconut oil sodium, 15 parts of stearic acid, 1 part of phosphatidase 1,12 parts of glycerine, ethanol 1-5 parts, 0.015 part of menthyl lactate,
40 parts of 0.7 part of citric acid, 0.5 part of disodium ethylene diamine tetraacetate, 35 parts of filler and water.
The Chinese mugwort slag tunning is Chinese mugwort slag products therefrom after saccharomycetes to make fermentation.
The filler is hydroxyethyl-β-cyclodextrin, methylcellulose and borax by weight 2:5:1 composition.
Preparation method is similar to Example 1.
A kind of gynaecology's handmade soap of comparative example 1
Gynaecology's handmade soap is made up of following components and its parts by weight：
End 3 parts of slag tunning, 1 part of 10-HAD, 0.3 part of chitosan oligosaccharide, 6 parts of rhamnolipid, sodium palmitate
25 parts, 15 parts of coconut oil sodium, 10 parts of stearic acid, 8 parts of phosphatide, 9 parts of glycerine, 3 parts of ethanol, 0.01 part of menthyl lactate, citric acid
45 parts of 0.5 part, 0.3 part of disodium ethylene diamine tetraacetate, 25 parts of filler and water.
The Chinese mugwort slag tunning is Chinese mugwort slag products therefrom after saccharomycetes to make fermentation.
The filler is hydroxyethyl-β-cyclodextrin, methylcellulose and borax by weight 1:1:1 composition.
Preparation method is similar to Example 1.
Difference with embodiment 2 is, the filler component：Hydroxyethyl-β-cyclodextrin, methylcellulose and borax
Weight ratio is by 2:5:1 is changed to 1:1:1.
A kind of gynaecology's handmade soap of comparative example 2
Gynaecology's handmade soap is made up of following components and its parts by weight：
End 3 parts of slag tunning, 1 part of 10-HAD, 0.3 part of chitosan oligosaccharide, 6 parts of rhamnolipid, sodium palmitate
25 parts, 15 parts of coconut oil sodium, 10 parts of stearic acid, 8 parts of phosphatide, 9 parts of glycerine, 3 parts of ethanol, 0.01 part of menthyl lactate, citric acid
45 parts of 0.5 part, 0.3 part of disodium ethylene diamine tetraacetate, 25 parts of filler and water.
The Chinese mugwort slag tunning is Chinese mugwort slag products therefrom after saccharomycetes to make fermentation.
The filler is hydroxyethyl-β-cyclodextrin, methylcellulose by weight 2:5 compositions.
Preparation method is similar to Example 1.
Difference with embodiment 2 is, borax is not added with the filler.
A kind of gynaecology's handmade soap of comparative example 3
Gynaecology's handmade soap is made up of following components and its parts by weight：
End 3 parts of slag tunning, 1 part of 10-HAD, 0.3 part of chitosan oligosaccharide, 25 parts of sodium palmitate, coconut oil sodium
15 parts, 10 parts of stearic acid, 4 parts of phosphatidase 1,9 parts of glycerine, 3 parts of ethanol, 0.01 part of menthyl lactate, 0.5 part of citric acid, ethylenediamine
45 parts of 0.3 part of tetraacethyl disodium, 25 parts of filler and water.
The Chinese mugwort slag tunning is Chinese mugwort slag products therefrom after saccharomycetes to make fermentation.
The filler is hydroxyethyl-β-cyclodextrin, methylcellulose and borax by weight 2:5:1 composition.
Preparation method is similar to Example 1.
Difference with embodiment 2 is, is not added with rhamnolipid, adds the dosage of phosphatide.
Test example one, safety testing
1) skin irritation is tested：
The embodiment 1-3 and comparative example 1-3 gynaecology's handmade soaps prepared are configured to the soap lye that concentration is 2.5wt% respectively,
0.3mL is taken, by HETVAM measurements determination dermoreactions, measurement result is shown in Table 1.Dermoreaction classification (is classified) with respect to values,
Intense stimulus ＞ 2.0, stimulate 1.2-2.0, medium stimulation 0.8-1.2, minimal irritation 0.0-0.8.
2) pH value is tested：
Each 2.5g of gynaecology's handmade soap prepared by embodiment 1-3 and comparative example 1-3 is weighed respectively, is respectively put into 6 conical flasks
In, respectively add sterile distilled water 50mL, vibrate to sample and be completely dissolved in 45 DEG C of water-baths, the pH value of soap lye is determined by pH analyzers,
Test result is shown in Table 1.
The security test result of table 1
| Group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| With respect to values (%) | 0.2 | 0.1 | 0.3 | 0.7 | 0.9 | 0.8 |
| PH value | 5.5 | 5.3 | 5.8 | 6.8 | 6.5 | 6.3 |
As shown in Table 1, gynaecology's handmade soap that prepared by the present invention is to no skin irritation, and the pH value of soap lye is 5.3-5.8.
Compared with comparative example 1-3, gynaecology's handmade soap soap lye prepared by 1-3 of the embodiment of the present invention is in faintly acid, closer to women privates acid
Basicity, moderate performance, the excitant in cleaning process is avoided, illustrate that filler in the present invention reduces the thorn of gynaecology's handmade soap
Swash property, make its moderate performance, nursed suitable for women privates.
Test example two, bacteriostatic test
1. test material：Gynaecology's handmade soap prepared by embodiment 1-3 and comparative example 1-3.
2. subjects：Escherichia coli ATCC25922, staphylococcus aureus ATCC6538, Candida albicans
ATCC10231。
3. test method：
1) each 5g of gynaecology's handmade soap prepared by embodiment 1-3 and comparative example 1-3 is weighed respectively, is respectively put into 6 conical flasks
In, respectively add sterile distilled water 25mL, vibrate to sample and be completely dissolved in 45 DEG C of water-baths, be configured to 1:5 antibacterial agent solution；
2) concentration is dipped as 5 × 10 with aseptic cotton carrier6Cfu/mL tests bacteria suspension, is squeezed on tube wall and goes unnecessary bacterium solution, applied
The whole nutrient agar planar surface of cloth, 3 times repeatedly；Often smear 1 time, flat board rotates 60 degree, and coating is uniform, finally by cotton
Label are smeared one week around plate edge；Plate is covered, puts drying at room temperature 5min；Stick susceptibility piece to be measured and negative control print, 37
Fungistatic effect is observed after DEG C 16~24h of culture, measures inhibition zone diameter, inhibition zone diameter is bigger, and fungistatic effect is better.
4. result of the test：Gynaecology's handmade soap In Vitro Bacteriostasis the results are shown in Table 2.
The gynaecology's handmade soap In Vitro Bacteriostasis result of table 2
As shown in Table 2, compared with comparative example 1-3 groups, the antibacterial effect of gynaecology's handmade soap prepared by 1-3 of embodiment of the present invention groups
Fruit is preferable, illustrates that the acid-base value of gynaecology's handmade soap prepared by the present invention is more suitable for active ingredient and plays its fungistatic effect, and each group
Split-phase mutually cooperates with, and plays antibacterial effect jointly.
Test example three, anti-inflammatory experiment
1. test material：Gynaecology's handmade soap prepared by embodiment 1-3, comparative example 1-3.
2. subjects：Mouse 60, body weight 28-34g, male and female half and half.
3. content of the test：
1) mouse is randomly divided into 6 groups, every group 10, is denoted as embodiment 1-3 groups, comparative example 1-3 groups；
2) dimethylbenzene 0.04ml drops are caused into inflammation in mouse right ear, left ear is as control；
3) 30min smears soap lye, Ji Qu gynaecology handmade soap soap lye after inflammation is caused respectively for embodiment 1-3 groups, comparative example 1-3 groups
(1g/mL) each 3mL is added on 2.0cm × 3.5cm 4 layers of gauze, is affixed on auris dextra, after being covered with one layer of oilpaper, uses immobilization with adhesive tape.
Mouse is dislocated after 2 hours and put to death, two ears are cut along auricle baseline, with diameter 6mm card punch respectively in the same portion of left and right ear
Round auricle is laid in position, weighs, and calculates swelling and swelling rate, swelling=auris dextra sheet weight-left auricle weight, swelling rate=swollen
Expansibility/left auricle weight × 100%.Using swelling rate as the index for weighing antiphlogistic activity, swelling rate is smaller to show disappearing for medicine
Scorching activity is better.
4. result of the test：Gynaecology's craft saponaria vaccaria the results are shown in Table 3.
The gynaecology's craft saponaria vaccaria result of table 3
| Group | Swelling/mg | Swelling rate/% |
| Embodiment 1 | 9.28 | 64.2 |
| Embodiment 2 | 8.92 | 61.5 |
| Embodiment 3 | 9.12 | 62.9 |
| Comparative example 1 | 10.18 | 70.2 |
| Comparative example 2 | 10.74 | 74.1 |
| Comparative example 3 | 10.50 | 72.4 |
As shown in Table 3, with comparative example 1-3 contrast, 1-3 of the embodiment of the present invention prepare gynaecology's handmade soap anti-inflammatory effects compared with
It is good, illustrate each component interaction of the present invention, cooperate with the effect of playing antiphlogistic antibacterial, help lend some impetus to the healing of privates wound.
Test example four, antipruritic experiment
1. test material：Gynaecology's handmade soap prepared by embodiment 1-3, comparative example 1-3.
2. subjects：Cavy 70, body weight 700-800g, male and female half and half.
3. content of the test：
1) cavy is randomly divided into 7 groups, every group 10, is denoted as control group, embodiment 1-3 groups and comparative example 1-3 groups；
2) cavy waking state bottom right metapedes loses hair or feathers, and will be abraded after 24h at depilation with fine sandpaper, control group, embodiment 1-3
Group and comparative example 1-3 the groups 15min before causing to itch smear gynaecology's handmade soap soap prepared by water, embodiment 1-3 and comparative example 1-3 respectively
Liquid (1g/mL)；
3) every animal only causes to itch in the abrasion drop μ l/ of 0.01% histamine phosphate 50, is then dripped successively every 3min
0.01%th, 0.03%, 0.06%, 0.09%, 0.12%, 0.15%, 0.18%, 0.20% histamine phosphate, 50 μ L/, until going out
It is standard that existing cavy, which later licks right metapedes, and the total cumulant of the histamine phosphate given when being turned one's head using cavy and licked right metapedes is itched as cause
Threshold.Show that test medicine antipruritic curative effect is better more greatly using itch-threshold as the index for weighing each group soap lye antipruritic, itch-threshold.
4. result of the test：Gynaecology's handmade soap antipruritic the results are shown in Table 4.
The gynaecology's handmade soap antipruritic result of table 4
| Group | Number of animals/only | Itch-threshold/μ g |
| Control group | 10 | 30.1±9.5 |
| Embodiment 1 | 10 | 60.8±11.3**●▲◆ |
| Embodiment 2 | 10 | 70.4±12.5**●●▲▲◆◆ |
| Embodiment 3 | 10 | 65.1±10.9**●●▲▲◆ |
| Comparative example 1 | 10 | 42.1±10.3* |
| Comparative example 2 | 10 | 40.5±8.6* |
| Comparative example 3 | 10 | 43.8±9.7* |
Note：* compared with control group, P<0.05；* is compared with control group, P<0.01；●Compared with 1 group of comparative example, P<
0.05；●●Compared with 1 group of comparative example, P<0.01；▲Compared with 2 groups of comparative example, P<0.05；▲▲Compared with 2 groups of comparative example, P<
0.01；◆Compared with 3 groups of comparative example, P<0.05；◆◆Compared with 3 groups of comparative example, P<0.01.
As shown in Table 4, with comparative example 1-3 contrast, 1-3 of the embodiment of the present invention prepare gynaecology's handmade soap antipruritic effect compared with
It is good, and there is conspicuousness, illustrate that gynaecology's handmade soap inhibiting bacteria and diminishing inflammation effect prepared by the present invention is preferable, and acid-base value is suitable, effectively
Prevented and treated itch.
Test example five, sensory evaluation
1. test material：Gynaecology's handmade soap prepared by embodiment 1-3, comparative example 1-3.
2. subjects：120 people, gynaecological imflammation patient, 22-50 year.
3 test methods：
Subject is randomly divided into 6 groups, every group of 20 people, is denoted as embodiment 1-3 and comparative example 1-3 groups.Each group uses respectively
Gynaecology's handmade soap prepared by embodiment 1-3 and comparative example 1-3, situation marking evaluation is used for once a night, after January.Comment
Minute mark is accurate：Using ten point system, 10 points best, and 0 point worst, and fraction more high effect is better.
4 result of the tests：Analyses Methods for Sensory Evaluation Results is shown in Table 5.
The Analyses Methods for Sensory Evaluation Results of table 5
As shown in Table 5, gynaecology's handmade soap for preparing of the present invention has a cleaning force of appropriateness, good antibacterial, anti-inflammatory, antipruritic
Effect, vagina normal ph and wettability can be effectively maintained, promotes the healing of site of injury, can effectively alleviate gynaecological imflammation.
Gynaecology's handmade soap filler of the present invention can reduce the degreasing power of handmade soap, excitant, acid-base value, and effectively having played it has
The antibacterial of composition, anti-inflammatory, antipruritic effect are imitated, each component interaction, promotes wound healing, effectively alleviates gynaecological imflammation.
Claims (8)
1. a kind of gynaecology's handmade soap, it is characterised in that including following components and its parts by weight：
End slag tunning 1-5 parts, 10-HAD 0.5-1.5 parts, chitosan oligosaccharide 0.1-0.5 parts, rhamnolipid 4-8
Part, sodium palmitate 20-30 parts, coconut oil sodium 10-20 parts, stearic acid 5-15 parts, -11 parts of phosphatidase 5, glycerine 6-12 parts, ethanol 1-5
Part, menthyl lactate 0.005-0.015 parts, citric acid 0.3-0.7 parts, disodium ethylene diamine tetraacetate 0.1-0.5 parts, filler
15-35 parts and water 40-50 parts.
2. gynaecology's handmade soap as claimed in claim 1, it is characterised in that be made up of following components and its parts by weight：End slag hair
3 parts of ferment product, 1 part of 10-HAD, 0.3 part of chitosan oligosaccharide, 6 parts of rhamnolipid, 25 parts of sodium palmitate, coconut oil sodium 15
Part, 10 parts of stearic acid, 8 parts of phosphatide, 9 parts of glycerine, 3 parts of ethanol, 0.01 part of menthyl lactate, 0.5 part of citric acid, ethylenediamine tetrem
45 parts of 0.3 part of acid disodium, 25 parts of filler and water.
3. gynaecology's handmade soap as claimed in claim 1 or 2, it is characterised in that the Chinese mugwort slag tunning is Chinese mugwort slag through yeast
Products therefrom after bacterium fermentation.
4. gynaecology's handmade soap as claimed in claim 1 or 2, it is characterised in that the filler be hydroxyethyl-β-cyclodextrin,
Methylcellulose is with borax by weight 2:5:1 composition.
5. the preparation method of gynaecology's handmade soap as described in claim 1-4 is any, it is characterised in that comprise the following steps：
S1 adds Chinese mugwort slag tunning, 10-HAD and menthyl lactate into ethanol, and stirring obtains molten to dissolving
Liquid A；
Disodium ethylene diamine tetraacetate is added to the water by S2, is heated to 70-80 DEG C, stirring adds sodium palmitate, coconut to after dissolving
Oleic acid, stearic acid, phosphatide and glycerine, 20-40min is stirred, obtains mixture B；
Mixture B obtained by step S2 is cooled to 40-50 DEG C by S3, and it is few that stirring adds step S1 resulting solutions A, rhamnolipid, shell
Sugar and citric acid, 30-40min is stirred, obtains mixture C；
Mixture C obtained by step S3 is cooled to 30-40 DEG C by S4, adds filler, is stirred 5-15min, is poured into mould, is air-dried,
Produce.
6. the preparation method of gynaecology's handmade soap as claimed in claim 5, it is characterised in that heating-up temperature is in the step S2
75 DEG C, mixing time 30min.
7. the preparation method of gynaecology's handmade soap as claimed in claim 5, it is characterised in that chilling temperature is in the step S3
45 DEG C, mixing time 35min.
8. the preparation method of gynaecology's handmade soap as claimed in claim 5, it is characterised in that chilling temperature is in the step S4
35 DEG C, mixing time 10min.
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| CN109576094A (en) * | 2018-11-22 | 2019-04-05 | 广东大鹏医药科技有限公司 | A kind of handmade soap and preparation method thereof containing trollflower stem cell extract |
| CN109321390A (en) * | 2018-11-29 | 2019-02-12 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of bloodstain cleaning agent and its preparation and application |
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| CN107400579B (en) | 2020-10-20 |
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