CN109568647A - Foam type chitosan liquid film and preparation method thereof - Google Patents
Foam type chitosan liquid film and preparation method thereof Download PDFInfo
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- CN109568647A CN109568647A CN201711448173.XA CN201711448173A CN109568647A CN 109568647 A CN109568647 A CN 109568647A CN 201711448173 A CN201711448173 A CN 201711448173A CN 109568647 A CN109568647 A CN 109568647A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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Abstract
The invention discloses a kind of foam type chitosan liquid films and preparation method thereof, and specifically foam type wound thimerosal provided by the invention coats wound with form of foam, and the film for covering the wound is formed after foam dehydration；The wound thimerosal includes chitosan.In wound thimerosal of the present invention containing chitosan, it is coated in wound, it can be with the uniform fold surface of a wound, the foaming abundancy duration is long, it can be covered with the long period, stable, soft, flexible chitosan film can be formed after foam dehydration, can prevent trauma surface infestation, the sterilizing function with infective wound surface.
Description
Technical field
The invention belongs to medical field, it is related to a kind of foam type wound thimerosal and preparation method thereof.
Background technique
Skin refers to tissue of the body surface packet outside muscle, is not only outside the maximum organ of human body and body defenses
The first layer barrier of portion's invasion.The damage of skin histology can directly cause the destruction of subcutaneous tissue.In daily life and work
In, often there is the wound that external force causes skin cracks bleeding, subcutaneous tissue to communicate with the outside world.The use of wound thimerosal is for skin
The healing of skin damage is extremely important, can protect the wound from external further infringement, infringement including physical contact property and thin
The infection of the microorganisms such as bacterium.
Existing day commonly uses wound thimerosal, still based on liquid.If although covering traditional adhesive bandage again has
Hemostasis by compression, protection the surface of a wound, it is small in size, using it is simple the advantages that.But its poor air permeability causes steam and sweat that can not penetrate,
Make the skin whitening of wound and wound circumference, soften, and then cause secondary to be microorganism infection, aggravates the deterioration of wound.In addition,
In wound healing process, adhesive bandage is often closely adhered to each other with cambium, is difficult to remove after Wound healing, very
It is easy to cause the tearing of cambium.
In addition: human body natural's cavity is generally also easy infection inflammation, and liquids in general thimerosal is not easy to stop in the surface of a wound, make
With also inconvenience, the ideal effect of disinfection is also not achieved, is less susceptible to protect using auxiliary material.
In view of this, nowadays there is an urgent need to design a kind of novel wound thimerosal, to overcome existing disinfection+shield wound side
Drawbacks described above existing for formula.
Summary of the invention
The purpose of the present invention is to provide a kind of foam type wound thimerosal (foam type chitosan liquid film) and its preparations
Method.
The first aspect of the present invention provides a kind of wound thimerosal, and the wound thimerosal is coated with form of foam and created
Mouthful, and the film for covering the wound is formed after foam dehydration.
In another preferred example, the wound thimerosal is stored in the form of liquid charging stock composition (aqueous solution).
In another preferred example, the wound thimerosal includes chitosan；Preferably, in the liquid charging stock composition,
The chitosan concentration is 0.25wt%~2.0wt%；It is highly preferred that the chitosan concentration is 0.5wt%~2.0wt%；
Most preferably, the chitosan concentration is 0.75wt%~1.5wt%.
In another preferred example, the wound thimerosal further includes surfactant；Preferably, the liquid charging stock combination
In object, the concentration range of the surfactant is 0~0.1wt%；Preferably 0.001wt%~0.1wt%；More preferably
Ground, concentration range 0.001wt%~0.05wt% of the surfactant.
In another preferred example, the wound thimerosal further includes glacial acetic acid；Preferably, the liquid charging stock composition
In, concentration range 0.5wt%~3.0wt% of the glacial acetic acid；It is highly preferred that in the liquid charging stock composition, the ice
Concentration range 0.5wt%~2.0wt% of acetic acid；Most preferably, in the liquid charging stock composition, the concentration of the glacial acetic acid
Range 0.5wt%~1.5wt%.
In another preferred example, the surfactant is nonionic surfactant.
In another preferred example, the surfactant is selected from the group below one or more: tween (such as polysorbas20, tween
60, Tween 80), Span (such as Span 20, Span 60, Span 80).
In another preferred example, the wound thimerosal further includes analgesic drug product or/and anti-inflammation drugs.
In another preferred example, the analgesic drug product is selected from the group below one or more: aspirin, brufen.
In another preferred example, the anti-inflammation drugs are selected from the group below one or more: antibiotic.
In another preferred example, in the liquid charging stock composition, the analgesic drug product content be 0.01wt%~
2wt%.
In another preferred example, in the liquid charging stock composition, the anti-inflammation drugs content be 0.01wt%~
2wt%.
In another preferred example, the pH of the liquid charging stock composition is about 4.0~6.5；It is highly preferred that the liquid is former
The pH of feed composition is about 4.0~5.5.
In another preferred example, the molecular weight 20-50 ten thousand of the chitosan；It is highly preferred that the molecular weight of the chitosan
20-30 ten thousand.
The second aspect of the present invention provides a kind of wound thimerosal spray equipment, described device include disinfectant container,
With the spray head for being connected to the disinfectant container, equipped with forming wound described in first aspect present invention in the disinfectant container
The liquid charging stock composition of thimerosal, the liquid charging stock composition form foam from after spray head ejection.
In another preferred example, the spray head includes foam pump head (foam nozzle).
In another preferred example, the disinfectant container is pressure vessel.
In another preferred example, the wound thimerosal spray equipment is pressing bottle.
In another preferred example, the liquid charging stock composition includes chitosan；Preferably, the liquid charging stock composition
In, the chitosan concentration is 0.25wt%~2.0wt%.
In another preferred example, the liquid charging stock composition further includes surfactant；Preferably, the liquid charging stock
In composition, concentration range 0.001wt%~0.1wt% of the surfactant.
In another preferred example, the liquid charging stock composition further includes glacial acetic acid；Preferably, the liquid charging stock combination
In object, concentration range 0.5wt%~3.0wt% of the glacial acetic acid.
The third aspect of the present invention provides the method for wound thimerosal described in preparation first aspect present invention, described
Method comprising steps of
(1) liquid feedstock composition is prepared
The liquid charging stock composition includes chitosan, He Shui, glacial acetic acid；
(2) foam disinfectant liquid is prepared
The liquid charging stock composition is prepared into foam, forms foam disinfectant liquid；
(3) dry
Chitosan film will be formed after the dry dehydration of the foam disinfectant liquid.
In another preferred example, in the liquid charging stock composition, the chitosan concentration be 0.25wt%~
2.0wt%.
In another preferred example, the liquid charging stock composition further includes surfactant；Preferably, the liquid charging stock
In composition, concentration range 0.001wt%~0.1wt% of the surfactant.
In another preferred example, the surfactant is nonionic surfactant.
In another preferred example, the liquid charging stock composition is stored in the pressing that can spray foam by the step (2)
In bottle, bottleneck is pressed, the liquid charging stock composition is sprayed with form of foam, to form the foam disinfectant liquid.
It should be understood that above-mentioned each technical characteristic of the invention and having in below (eg embodiment) within the scope of the present invention
It can be combined with each other between each technical characteristic of body description, to form a new or preferred technical solution.As space is limited, exist
This no longer tires out one by one states.
Detailed description of the invention
Fig. 1 is the flow chart of the preparation method of foam type chitosan liquid film of the present invention.
Fig. 2 shows the foam that the wound thimerosal of embodiment 4 is formed.
Fig. 3 shows the foam that the wound thimerosal of comparative example 1 is formed.
Fig. 4 shows the foam that the wound thimerosal of comparative example 2 is formed.
Specific embodiment
Wound thimerosal of the invention coats wound with form of foam, and is formed after foam dehydration and cover the wound
Film.Wound thimerosal (herein also referred to as " foam type chitosan liquid film " or " foam type chitosan liquid film ") of the invention
In contain chitosan, be coated in wound, can be with the uniform fold surface of a wound, the foaming abundancy duration is long, can be covered with the long period,
Stable, soft, flexible chitosan film can be formed after foam dehydration, can prevent trauma surface infestation, there is infective wound surface
Sterilizing function.The liquid film packed using auto spraying and be equipped with it is intracavitary using conduit, it is easy to use.The present invention is directed to open
A kind of chitosan solution can be sprayed at the surface of a wound by foam type form, form chitosan liquid film, chitosan film, most
It is absorbed by the body eventually.
Traditional solid and liquid adhesive bandage is both needed to remove from wound, remove improper easy to form after wound healing
New wound can be absorbed by tissue with Wound healing since chitosan is absorbable macromolecule, not will cause secondary damage
Wound.In addition it sprays to form film layer with foam type, be coated instead of common liq adhesive bandage brush, can reduce the mechanics thorn to wound
Swash, while chitosan has sterilization, bacteria resistance function, plays the role of to protecting wound surface.
The technical problems to be solved by the present invention are: providing a kind of preparation method of foam type chitosan liquid film, can lead to
It crosses foam type form to be sprayed at the surface of a wound, forms chitosan film.
In order to solve the above technical problems, the present invention adopts the following technical scheme:
A kind of preparation method of foam type chitosan liquid film, the preparation method include:
Step S1, chitosan, surfactant, deionized water, glacial acetic acid, analgesic or/and the anti-inflammatory of setting ratio are measured
Drug；Chitosan concentration is 0.25wt%~2.0wt%, and glacial acetic acid concentration is 0.5wt%~2.0wt%, surfactant
Concentration range 0.001wt%~0.1wt%；Surfactant is nonionic surfactant；Surfactant includes tween, department
At least one of class；The analgesic drug product accounting is 0.01%~2%；The anti-inflammation drugs accounting is 0.01%~2%；
Step S2, chitosan, surfactant, deionized water that step S1 is measured are uniformly mixed, form foam type shell
Glycan liquid film；
Step S3, pH value is added to uniformly mixed liquid coating solution and adjusts liquid so that the pH of liquid coating solution be 4~
5.5；
Step S4, the foam type chitosan liquid film mixed is stored in the pressing bottle for spraying foam；
Step S5, bottleneck is pressed when using, solution is coated uniformly on wound face with form of foam, forms chitosan liquid
Film.
A kind of preparation method of foam type chitosan liquid film, the preparation method include:
Step S1, chitosan, aqueous solution, glacial acetic acid, the surfactant of setting ratio are measured；Chitosan concentration is
0.25wt%~2.0wt%, glacial acetic acid concentration are 0.5wt%~2.0wt%, the concentration range 0.001wt% of surfactant
~0.1wt%；
Step S2, chitosan, aqueous solution, surfactant that step S1 is measured are uniformly mixed, it is poly- forms foam type shell
Sugar liquors film.
As a preferred solution of the present invention, the method also includes step S3: to uniformly mixed liquid coating solution
PH value is added and adjusts liquid, so that the pH of liquid coating solution is 4~5.5.
As a preferred solution of the present invention, the surfactant is nonionic surfactant.
As a preferred solution of the present invention, the surfactant includes at least one of tween, Span.
As a preferred solution of the present invention, the preparation method further includes step S3: the foam type shell that will be mixed
Glycan liquid film is stored in the pressing bottle for spraying foam.
As a preferred solution of the present invention, bottleneck is pressed when use, solution is coated uniformly on wound with form of foam
On face, chitosan liquid film is formed.
As a preferred solution of the present invention, in the step S1, in preparing material choose set amount analgesic or/
And anti-inflammation drugs.
As a preferred solution of the present invention, the analgesic drug product accounting is 0.01%~2%.
As a preferred solution of the present invention, the anti-inflammation drugs accounting is 0.01%~2%.
The beneficial effects of the present invention are: the preparation method of foam type chitosan liquid film proposed by the present invention utilizes shell
Glycan solution is sprayed at wound by foam type form, forms chitosan film.
Referring to Fig. 1, being preferably carried out in mode at of the invention one, the preparation for the wound thimerosal that the present invention discloses
Method, comprising:
Chitosan, surfactant, deionized water, glacial acetic acid, analgesic or/and the anti-inflammatory of [step S1] measurement setting ratio
Drug；Chitosan concentration is 0.25wt%~2.0wt%, and glacial acetic acid concentration is 0.5wt%~2.0wt%, surfactant
Concentration range 0,001wt%~0.1wt%；Surfactant is nonionic surfactant；Surfactant includes tween, department
At least one of class；The analgesic drug product accounting is 0.01%~2%；The anti-inflammation drugs accounting is 0.01%~2%；
The chitosan, surfactant, deionized water that step S1 is measured are uniformly mixed by [step S2], form foam type shell
Glycan liquid film；
[step S3] is added pH value to uniformly mixed liquid coating solution and adjusts liquid, so that the pH of liquid coating solution is 4
~5.5；
The foam type chitosan liquid film mixed is stored in the pressing bottle for spraying foam by [step S4]；It is pressed when use
Pressure bottle mouth, solution are coated uniformly on wound face with form of foam, form chitosan liquid film.
It is preferably carried out in mode in of the invention another, the preparation method for the wound thimerosal that the present invention discloses, packet
It includes:
Step S1, chitosan, aqueous solution, glacial acetic acid, the surfactant of setting ratio are measured；Chitosan concentration is
0.25wt%~2.0wt%, glacial acetic acid concentration are 0.5wt%~2.0wt%, the concentration range 0,001wt%- of surfactant
0.1wt%；
Step S2, chitosan, aqueous solution, surfactant that step S1 is measured are uniformly mixed, it is poly- forms foam type shell
Sugar liquors film.
Combined with specific embodiments below, the further old present invention in detail.It should be understood that these embodiments are merely to illustrate the present invention
Rather than it limits the scope of the invention.The experimental method of detailed conditions is not specified in the following example, usually according to manufactory
Condition proposed by quotient.Unless otherwise stated, otherwise percentage and number are calculated by weight.It is tested used in following embodiment
Material and reagent can obtain unless otherwise instructed from commercially available channel.
Embodiment 1
The preparation method of the wound thimerosal of the present embodiment, comprising:
(1) (analgesic, anti-inflammatory drug can be also added in the chitosan, water, glacial acetic acid, surfactant of regulated proportion as needed
Object) it is stored in the pressing bottle (such as the pressing bottle with foam pump head) that can spray foam, packaging configuration is intracavitary to use connection
Conduit；
(2) bottleneck is pressed when using, solution is coated uniformly on wound face with form of foam, and solvent volatilizees to form chitosan
Film.
Surfactant can be the nonionic surfactants such as tween, Span.
The optimization experiment of 1.pH value
The experimental results showed that being preferred in pH=4~5.5, chitosan dissolubility is had not significant impact, and meet medicament pair
PH requirement；The too low influence clinical application of pH, pH > 6, chitosan convergence separate out, are also easy to stop up nozzle when spraying from packaging.
2. chitosan concentration
Chitosan concentration experiment purpose is to improve solution concentration, accelerates film forming speed after spraying；Take 0.1% respectively,
0.25%, 0.5%, 0.75%, 1.0%, 1.25%, 1.5%, 2.0%, 2.5% concentration is tested, and finds maximum spray
Concentration is 2.0%.When concentration is greater than 2.0%, there is blocking spray head phenomenon.Chitosan concentration be lower than 0.2% when, film-formation result compared with
Difference, or even can not form a film.Final chitosan concentration is 0.25%-2.0wt%.Preferred chitosan concentration is 0.5wt%
~2.0wt%；Preferred chitosan concentration is 0.75wt%~1.5wt%.
3. the selection of surfactant
It was found that, foam, which can be improved, in addition surfactant sprays effect, live in R&D process to a variety of surfaces
Property agent is screened, and finally found that Tween 80, the effect of Span 80 are preferable, the concentration range of final surfactant is selected as
0.001wt%-0.1wt%.
4. the selection of molecular weight of chitosan
It was found that, molecular weight of chitosan, which sprays effect and foam duration effect to foam, larger impact, pass through
Screening discovery can achieve preferable effect using the chitosan that molecular weight is 20-30 ten thousand.
5. the selection of glacial acetic acid concentration
The preferred concentration of glacial acetic acid is screened, finally determined glacial acetic acid preferred concentration be 0.5wt%~
3.0wt% (more preferably 0.5wt%~2.0wt%, optium concentration are 0.5wt%~1.5wt%).In this concentration range, shell
Glycan dissolubility is preferable, not only has preferably at bubble effect, but also can guarantee suitable pH.
The preparation of 2 wound thimerosal of embodiment
The preparation method of the wound thimerosal of the present embodiment, comprising:
Chitosan, surfactant, deionized water, glacial acetic acid, analgesic and the anti-inflammatory drug of [step S1] measurement setting ratio
Object.Chitosan concentration is 0.25wt%, and the concentration of surfactant is 0.001wt%；The concentration of glacial acetic acid is 1.0wt%；Table
Face activating agent is Tween 80；Analgesic drug product content is 0.1wt%；Anti-inflammation drugs content is 0.1wt%.Surplus is deionized water.
The step S1 each component measured is uniformly mixed by [step S2], forms liquid charging stock composition；
[step S3] adjusts the pH value of liquid charging stock composition, so that pH is 4；
Liquid charging stock composition is stored in the pressing bottle with foam pump head that can spray foam by [step S4]；It uses
When press bottleneck, solution is sprayed with form of foam, since chitosan concentration is lower, only form mesh-like film after foam dehydration,
Complete film is not will form.
The preparation of 3 wound thimerosal of embodiment
The preparation method of the wound thimerosal of the present embodiment, comprising:
Chitosan, surfactant, deionized water, glacial acetic acid, analgesic and the anti-inflammatory drug of [step S1] measurement setting ratio
Object.Chitosan concentration is 1.0wt%, and the concentration of surfactant is 0.002wt%；Surfactant is Tween 80；Anodyne
Object content is 0.01wt%；Anti-inflammation drugs content is 0.01wt%；The concentration of glacial acetic acid is 1.5wt%.Surplus is deionized water.
The step S1 each component measured is uniformly mixed by [step S2], forms liquid charging stock composition；
[step S3] adjusts the pH value of liquid charging stock composition, so that pH is 5.5；
Liquid charging stock composition is stored in the pressing bottle with foam pump head that can spray foam by [step S4]；It uses
When press bottleneck, solution is coated uniformly on wound face with form of foam, and the film for covering the wound is formed after foam dehydration.
The preparation of 4 wound thimerosal of embodiment
The preparation method of the wound thimerosal of the present embodiment, comprising:
Chitosan, surfactant, deionized water, the glacial acetic acid of [step S1] measurement setting ratio.Chitosan concentration is
1.6wt%, the concentration of surfactant are 0.001wt%；Surfactant is Tween 80；The concentration of glacial acetic acid is 0.8wt%.
Surplus is deionized water.
The step S1 each component measured is uniformly mixed by [step S2], forms liquid charging stock composition；
[step S3] adjusts the pH value of liquid charging stock composition, so that pH is 5；
Liquid charging stock composition is stored in the pressing bottle with foam pump head that can spray foam by [step S4]；It uses
When press bottleneck, solution is sprayed with form of foam, forms film after foam dehydration.
As shown in Fig. 2, wound thimerosal manufactured in the present embodiment, sprays foaming abundancy, fine and smooth, foam edge no liquid,
Foam duration is long (the sustainable 2-3min of foam at room temperature), can form stable film after lather collapse.
Comparative example
Fig. 3 shows the foam that the wound thimerosal of comparative example 1 is formed, and foam is less, and the duration is short (at room temperature
Sustainable 35 seconds of foam), there is big quantity of fluid on periphery, is easy flowing, can not form stable film.
Fig. 4 shows the foam that the wound thimerosal of comparative example 2 is formed, and foam is less, and duration slightly shorter (room temperature
Sustainable 55 seconds of lower foam), there is a small amount of liquid on foam periphery.
All references mentioned in the present invention is incorporated herein by reference, independent just as each document
It is incorporated as with reference to such.In addition, it should also be understood that, after reading the above teachings of the present invention, those skilled in the art can
To make various changes or modifications to the present invention, such equivalent forms equally fall within model defined by the application the appended claims
It encloses.
Claims (10)
1. a kind of wound thimerosal, which is characterized in that the wound thimerosal coats wound, and foam dehydration with form of foam
The film for covering the wound is formed afterwards；Preferably, the wound thimerosal includes chitosan.
2. wound thimerosal as described in claim 1, which is characterized in that the wound thimerosal is with liquid charging stock composition shape
Formula storage.
3. wound thimerosal as described in claim 1, which is characterized in that the wound thimerosal further includes surfactant.
4. wound thimerosal as described in claim 1, which is characterized in that the wound thimerosal further include analgesic drug product or/
And anti-inflammation drugs.
5. a kind of wound thimerosal spray equipment, which is characterized in that described device includes disinfectant container and is connected to described disappear
The spray head of venom container stores the liquid charging stock combination of wound thimerosal as claimed in claim 2 in the disinfectant container
Object, the liquid charging stock composition form foam from after spray head ejection.
6. wound thimerosal spray equipment as claimed in claim 5, which is characterized in that the liquid charging stock composition includes shell
Glycan；Preferably, in the liquid charging stock composition, the chitosan concentration is 0.25wt%~2.0wt%.
7. wound thimerosal spray equipment as claimed in claim 6, which is characterized in that the liquid charging stock composition further includes
Surfactant；Preferably, in the liquid charging stock composition, the concentration range 0.001wt% of the surfactant~
0.1wt%.
8. wound thimerosal spray equipment as claimed in claim 7, which is characterized in that the liquid charging stock composition further includes
Glacial acetic acid；Preferably, in the liquid charging stock composition, concentration range 0.5wt%~3.0wt% of the glacial acetic acid.
9. the method for preparing wound thimerosal described in claim 1, which is characterized in that the method includes the steps:
(1) liquid feedstock composition is prepared
The liquid charging stock composition includes chitosan, He Shui, glacial acetic acid；
(2) foam disinfectant liquid is prepared
The liquid charging stock composition is prepared into foam, forms foam disinfectant liquid；
(3) dry
Film thimerosal will be formed after the dry dehydration of the foam disinfectant liquid.
10. a kind of preparation method of foam type chitosan liquid film, which is characterized in that the preparation method includes:
Step S1, chitosan, aqueous solution, glacial acetic acid, the surfactant of setting ratio are measured；Chitosan concentration is 0.25wt%
~2.0wt%, glacial acetic acid concentration are 0.5wt%~3.0wt%, the concentration range 0,001wt%-0.1wt% of surfactant；
Step S2, chitosan that step S1 is measured, aqueous solution, glacial acetic acid, surfactant are uniformly mixed, form foam type shell
Glycan liquid film.
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