201034693 六、發明說明： 【發明所屬之技術領域】 本發明係有關一種貼附在顏面、腕臂、足部等之化粧 品貼敷用凝膠片。更詳言之，係有關一種使用水凝膠外用 劑之護膚用凝膠貼敷片， 【先前技術】 本發明之化粧品貼敷用凝膠片係一種含有大量水之 水凝膠貼敷材的外用劑。其特徵係經由添加少許的疏水性 多元醇而使内含藥效成分等之水滲出至凝膠表面，並藉由 水等對所貼附之皮膚的滲透而可得到保濕效果等。 以往，專利文獻1係有關一種片狀貼敷劑，其特徵係 包含作為必要成分之水溶性高分子、多元醇、保濕成分、 交聯劑、美肌成分以及水等。此處之水溶性南分子係記載 明膠、聚丙烯酸鹽。該高含水的片狀貼敷劑之效果係對肌 膚持有適度的黏著性及保溼性，不僅製劑物性之安定性及 對肌膚安全性優異，同時，在使用時之使用感以及對肌膚 之貼敷效果優異。 專利文獻2係有關一種去皮脂用片狀貼敷劑，其特徵 係包含將含有經交聯之羧基的聚合物及/或其鹽之含水性 凝膠狀組成物之層設在支撐體的至少一面，而上述含水性 凝膠狀組成物之層更含有多元醇者。此處之含羧基的聚合 物係記載有聚丙烯酸、聚甲基丙烯酸、聚衣康酸、海藻酸、 羧甲基纖維素、明膠、果膠、羧甲基羥乙基纖維素、甲氧 基乙烯-順丁烯二酐共聚物等。 4 321801 201034693 專利文獻3係有關一種片狀含水凝膠，其係於具有網 眼構造之合成高分子中含浸至少包含水、界面活性劑以及 油性成分之溶液與溶液滲出促進劑的片狀含水凝膠，而該 溶液滲出促進劑係包含聚乙二醇、聚丙二醇、聚甘油等二 醇、多元醇等的聚合物者。 [先前專利文獻] [專利文獻] [專利文獻1]日本特開平08-188527號公報 f) [•專利文獻2]日本特開2002-020257號公報 [專利文獻3]日本特開2003-183147號公報 【發明内容】 [發明所欲解決之課題] 然而，由於自凝膠片滲出之水等的原本黏度，亦即， 極低的黏度而為乾澀觸感，因而有在使用時滴落在衣物類 之問題（垂流性），且使用中的密著感，使用後所感覺的效 〇果感（保濕感）並不足_。 在專利文獻1之公報中，雖有在使用時將較多量的水 有效率地排至外部之記載，然而，雖導入液體滲出之概念， 惟並未考量滲出液之狀態等，因而在使用性、使用感方面 並不足。 專利文獻2係有關一種去皮脂用片狀貼敷劑，係有效 地去除多餘的皮脂及污垢，同時在由皮膚剝離時不會伴隨 著痛楚，更可一面補充滋潤一面僅去除多餘的皮脂，然而 亦無液體滲出等之記載，特別在保溼感等方面不足。 5 321801 201034693 古在此方面，專利文獻3係使用如上述之非離子性水溶 性雨分子作為溶液渗出劑，由於滲出含有藥效成分等之溶 液，因此使用效果較高。然而’相較於甘油，該等非離子 性水溶性高分子之吸濕度較低，因此為了提高滲出溶液之 保濕性，需有吸濕度更高且發揮溶液渗出劑作用者。 本發明之課題係提供一種化粧品貼敷用凝膠片，該凝 膠片係在不使來自凝膠表面之溶液的滲出性降低且提高滲 出之溶液的保濕性下，同時解決在使用時容易滴落在衣物 上之所謂的垂流性之問題，且由於使用中之密著感，以及 ❹ 使用後，水分等滲透至經貼付的皮膚而可充分地得到效果 感（保濕感）。 [用以解決課題之手段] 本發明者等專心致志並進行檢討之結果發現，適量地 添加取自豆科植物之瓜爾豆種子的瓜爾膠（guar gum)經羥 丙基化之羥丙基瓜爾豆膠、與作為滲出劑之聚氧伸乙基甲 基葡萄糖苷時，則來自凝膠之溶液的滲出性不會降低，且 滲出溶液之黏度上开，對於垂流性之改善、使用中之密著 ν’ 感以及使用後感受到的效果感（保濕感）可得到明顯效果。 如此，本發明係有關一種化粧品貼敷用凝膠片，係至 夕包含具有網眼構J：之合成鬲分子、羥丙基瓜爾勝、濕潤 劑、作為滲出劑之聚氧伸乙基甲基葡萄糖苷以及水者，其 特徵係：在凝膠片100重量份中含有羥丙基瓜爾膠0 05 至3重量份、聚氧伸乙基甲基葡萄糖苷3至12重量份。 [發明效果] 321801 6 201034693 本發明之化粧品貼敷用凝膠片係如上所述，由於其構 成係至少包含.於包含羥丙基瓜爾膠之具有網眼構造的舍 成高分子中，含浸滲出凝膠體表面之水性液體的片狀水凝 膠、作為使上述液體滲出凝膠體表面之滲出劑的聚氧伸乙 基甲基葡萄糖苷、以及水，因而不會使來自凝膠之溶液的 滲出性降低並且提高滲出溶液之保溼性，同時，所滲出溶 液之黏度上升’對於垂流性之改善、使用中之密著感以及 使用後感受到的效果感（保濕感）玎得到明顯效果。 【實施方式】 (合成高分子） 合成高分子如為可形成網眼構造並形成至少含有水 之凝膠者即可，而無特別限制。水凝膠在化粧品的領域中 作為經皮用途使用時，可使用該領域中所容許之合成高分 子。特別疋使用具有親水性之合成高分子，然其中亦以耳 有陰離子性官能基之合成高分子更適用。如此之合成高分 C)子之例可列舉如：具有羧基作為官能基之丙烯酸、曱基丙 烯黪等聚合性不飽和單體之聚合物以及該等之鹽（例如鈉 鹽、卸鹽、二乙醇胺鹽等）；具有確基作為官能基之第三丁 基丙烯醯胺項酸等聚合性不飽和單體的聚合物以及該等之 鹽（例如納鹽、卸鹽等）。較佳之親水性高分.乎可，使·用聚内 烯酸鈉。較佳含量係在凝膠片100重量份中含有'0:5至35 重量份。 另外，交聯前之合成高分子只要不妨礙片狀水凝膠之 製造，且可進行部分交聯者即可。並且，如考量製造時之 321801 7 201034693 操作性，則宜使用重量平均分子量範圍在10萬至500萬之 交聯前的合成高分子。 (交聯劑） 合成高分子之網眼構造可經由交聯前之合成高分子 的交聯而得。亦即，在交聯前之合成高分子中添加交聯劑， 因應需要而加熱，即可得到網眼構造。 交聯劑之例可列舉如：氫氧化紹、卸明礬、硫酸銘、 甘胺酸鋁、醋酸鋁、氧化鋁、偏矽酸鋁、氣化鎂、氫氧化 鈣、碳酸鈣、偏矽酸鎂鋁、聚乙烯亞胺、聚乙二醇二縮水 甘油醚、甘油三縮水甘油鍵、異氰尿酸三縮水甘油S旨等。 較佳含量係在化粧品貼敷用凝膠片100重量份中含有 0. 1至5重量份。 (pH調整劑） 調整成交聯劑作用的最適pH，在更確實地交聯之目的 下，除了酒石酸、乳酸、乙醇酸等之α -羥基酸之外，亦可 將擰檬酸等各種有機酸或鹽酸等無機酸作為pH調整劑（酸 觸媒）使用。 較佳含量係在化粧品貼敷用凝膠片100重量份中含有 0. 1至10重量份者。 本發明之化粧品貼敷用凝膠片雖亦能以色素等著色， 惟以具有透明至幾乎透明之外觀者為佳。本發明之所謂透 明係將凝膠片置載於以黑色印有20點文字之白色優質紙 上時，以確保可判讀有無文字之程度的透明性者為佳。本 發明之化粧品貼敷用凝膠片中，在無損及凝膠片之透明性， 8 321801 201034693 二，旋膠片之撕裂強度與操作性之目的下，以凝膠片内 =厚度方向含有開口率充分大之織布或不織布者為佳。 键希+本發明中’開口率大之織布或不織布係指即使透過 '〔雄不織布仍可判讀具有2G點排版之程度的大開口率 匕維持著透明性）者。 ο 凝賑y發月之’、有透明至幾乎透明外觀的化粧品貼敷用 果^ ’純過經貼附之凝膠片除了可見到皮膚之改善效 果。”可正確地貼在所要部位之優異外觀的效 一本發明之化粧品貼敷用凝膠片的厚度，即使整體均 声然=度亦可不同，惟為了確保密著性、透明性與 片之強度較弱，或超出Si佳 〇 而有密著性不足的情形。另外，凝夥片整片本身的重=重 可將凝膠片一部分加厚至之厚度不足時， (麵丙基瓜爾膠） 爾豆= 丙基瓜爾膠細豆科植物的瓜 爾膠為萨由盥1:刀所3的天然水溶性高分子多醣類之瓜 風 及環氧槐反應等之方法， 土代為經丙基而得之非離子性聚合物。 素、瓜爾膠、陽離子化瓜爾纖 等多_及其衍生物等即可提升水凝膠 321801 9 201034693 可解決’惟凝膠本身的保水性上升而會有來自凝膠之含藥 液成分等的溶液滲出受到抑制之問題發生，另一方面，滲 出溶液之點度不上升而為原乾溫觸感，對上述之改善效果 不足。 羥丙基瓜爾膠中之羥丙基的取代度以〇. 4至1.2者為 佳。更佳為0.6至1.〇者的效果更高。 羥丙基瓜爾膠係在化粧品貼敷用凝膠片100重量份中 含有0. 05至3重量份。羥丙基瓜爾膠在化粧品貼敷用凝膠 片100重量份中未達0.05重量份時’相較於不含羥丙基瓜 爾膠者，未改善垂流性，且在使用中之密著感降低，使用 後所感受到的保溼感亦降低。羥丙基瓜爾膠之含量在化被 品貼敷用凝膠片1〇〇重量份中超出3重量份時，由於出現 強烈的粘腻感’因而使用時之使用感惡化而不佳。較佳之 羥丙基瓜爾膠在化粧品貼敷用凝膠片1〇〇重量份中含有 〇.1至2重量份，其中以〇 2至！重量份最為適當。 (滲出劑） 表面而使== 狀轉有效轉出水凝膠 配-種既為親水:而亦稱為溶液參出促進劑。例如經由調 可使水凝膠内:= = =程度之疏水性的物質，即 基甲Si::非離子性水溶性高分子係使用聚氧伸乙 聚氧伸乙基甲其盆— 1〇〇重量份中a入a韌甸糖苷係在化粧品貼敷用凝膠片 3有3至12重量份。聚氧伸乙基甲基葡萄 321801 10 201034693 y 糖苷在化粧品貼敷用凝膠片100重量份中未達3重量份 — 時，因逸、著感、效果感不足而不佳。聚氧伸乙基甲基葡萄 糖苷在化粧品貼敷用凝膠片100重量份中係超出12重量份 時，因滲出量過多使垂流性差而不佳。更佳範圍為6至 重量份。 ， 聚氧伸乙基甲基葡萄糖苷在以甘油之吸溼度為1〇〇 時，係吸溼率70之非離子性水溶性高分子。吸溼率大之非 0離子性水溶性高分子所具有之保水力雖大，惟具有使水凝 膠内之溶液滲出水凝膠表面之能力，而更提高滲出溶液之 濕潤感以及保溼效果。 (濕潤劑） 濕潤劑之例可列舉如：乙二醇、二乙二醇、三乙二醇、 丙二醇、二丙二醇、甘油、二甘油、異丙二醇、1，3-丁二醇、 山梨糖醇、麥芽糖醇、海藻糖、棉子糖、木糖醇、 甘露醇、玻尿酸及其鹽、海藻糖及棉子糖等之各種衍生物、 〇 三甲基甘胺酸、環糊精、玻尿酸及其鹽等二醇類、多元醇 類及多糖類等。該等可單獨或混合2種以上使用。 該專濕潤劑之較佳含量係在化粧品貼敷用凝膠片10 0 重量份中含有1至30重量份。 (藥效成分） 本發明中可調配之藥效成分只要為以往醫藥品、藥粧 品（quasi drug)、化粧品、衛生材料、雜貨等所使用者即 可，而無特別限定，其例可列舉如：明日葉萃取物、酪架 萃取物、甘茶萃取物、藥蜀葵萃取物、山金車萃取物、山 11 321801 201034693 杏萃取物、杏核萃取物、小茴香萃取物、薑黃萃取物、烏 龍茶萃取物、紫錐菊葉萃取物、黃芩萃取物、黃柏萃取物、 大麥萃取物、荷蘭芥末萃取物、柑橘萃取物、海水乾燥物、 水解彈性蛋白、水解小麥粉末萃取物、水解乳萃取物、洋 甘菊萃取物、胡蘿蔔萃取物、茵蒎蒿萃取物、甘草萃取物、 洛神花萃取物、奇異果萃取物、奎寧萃取物、小黃爪萃取 物、鳥嘌呤核苷、山白竹萃取物、核桃萃取物、葡萄柚萃 取物、鐵線蓮萃取物、酵母萃取物、牛蒡萃取物、紫草萃 取物、膠原蛋白、蔓越莓萃取物、柴胡萃取物、臍帶萃取 液、一串紅萃取物、肥皂草萃取物、竹萃取物、野山楂 (Crataegus cuneata)萃取物、香益萃取物、地黃萃取物、 紫根萃取物、華東椴萃取物' 繡線菊萃取物、菖蒲根萃取 物、白樺萃取物、木賊萃取物、金銀花萃取物、常春藤萃 取物、歐山楂（Crataegus oxyacantha)萃取物、黑接骨木 (Bleak elder)萃取物、洋蓍草萃取物、歐薄荷萃取物、錦 葵萃取物、大棗萃取物、百里香萃取物、丁香萃取物、白 茅萃取物、陳皮萃取物、苦橙皮萃取物、魚腥草萃取物、 蕃茄萃取物、納豆萃取物、人蔘萃取物、野玫瑰萃取物、 木槿花萃取物、麥門冬萃取物、香芹萃取物、蜂蜜、藥用 牆草萃取物、藍萼香茶菜萃取物、沒藥醇萃取物、款冬蒲 公英萃取物、蜂斗菜萃取物、茯苓萃取物、假葉樹萃取物、 葡萄萃取物、蜂膠萃取物、絲瓜萃取物、薄荷萃取物、概 樹萃取物、哮酒彳t*萃取物、松樹皮萃取物、七葉樹萃取物、 水芭蕉萃取物、無患子萃取物、蜜桃萃取物、矢車菊萃取 12 321801 201034693 物、尤加利樹萃取物、香撥萃取物、艾草萃取物、薰衣草 萃取物、蘋果萃取物、萵苣萃取物、檸檬萃取物、紫雲英 萃取物、玟魂花萃取物、迷迭香萃取物、羅馬洋甘菊萃取 物、蜂王漿萃取物等。 亦可列舉如：去氧核糖核酸、硫酸軟骨素鈉、膠原蛋 白、彈力蛋白、幾丁質、幾丁聚糖（chitosan)、水解卵殼 膜等之生物高分子；胺基酸、尿素、吡咯啶酮羧酸鈉、甜 ❹菜鹼、乳清、三甲基甘胺酸等保溼成分；神經鞘脂質、神 經醯胺、膽固醇、膽固醇衍生物、磷脂質等油性成分；ε_ 胺基己酸、甘草酸、0 -甘草次酸、氣化溶菌酶、愈創藍油 煙、皮質醇等抗發炎劑；維他命A、維他命β、維他命Β6、 維他命D、維他命E、泛酸鈣、生物素、菸鹼醯胺等維他命 類；尿囊素、二氯乙酸二異丙胺、4-胺基曱基環己烷羧酸 等活性成分，生育紛、類胡蘿蔔素、類黃酮、單寧、木齡 素（1 ignan)、皂素等抗氧化劑；r —米糠醇、維他命e衍生 〇 物等血液循環促進劑；視網醇、視網醇衍生物等傷口瘡合 劑；頭花千金藤素、辣椒酊、檜木醇、含碘大蒜精、鹽酸 吡哆醇、（Π-α-生育酚、dl-α生育酚醋酸酯、菸鹼酸、菸 鹼酸衍生物、泛酸鈣、D-泛醇、乙醯泛醇基乙基醚、生物 素、尿囊素、異丙基甲基驗、雖二醇、乙快.基雖醇、卡 普氯敍（Carpronium Chloride)、氣化苯二曱烴銨… (benzalkonium chloride)、鹽酸笨海拉明 (Diphenhydramine Hydrochloride)、感光素（Takanal)、 樟腦、水楊酸、壬酸香草酷胺、吼羅克酮乙醇胺鹽、十五 321801 201034693 烧酸甘油醋、單硝基愈創木驗、間苯二齡、^ -胺基丁酸、 氯化苯鍵松寧（benzethonium chloride)、鹽酸美西律 (Mexiletine Hydrochloride)、苗長素（auxin)、女性荷爾 蒙、斑蟲釘（Cantharides tincture)、環孢靈 (Cyclosporin)、氫化可體松（hydrocotisone)、聚氧伸乙 基山梨醇酐單硬脂酸酯、止痛劑、精神安定劑、降血壓劑、 抗生素、抗組織胺劑、抗菌性物質等。 該等成分之調配量因其材料而有效成分量不同而無 法統一規定，惟一般相對於化粧品貼敷用凝膠片之質量， 係以0. 05至30質量％者為佳。 (製造方法） 例如可採用之方法係在至少將合成高分子、羥丙基瓜 爾膠、濕潤_及水混合而得的混合物巾，再添加交聯劑 ”作為參出劑之聚氧伸乙基曱基葡萄糖苷加以混合並使之 反應者。可採用之較佳的製造方法，其特徵係：添加邱 調整劑（酸觸媒）使混合溶液之PH值調整為4至7並使之反 其中最重要者係將㈣基瓜轉預先添加在合成 潤劑中使經丙基瓜爾膠溶解後，再添加交聯劑 〜出劑之聚氧伸乙基甲基葡萄糖芽之點。換言之， 基甲基葡萄糖苷在室溫中為液體而無問題， 膠係:形膠係在形成凝膠之前添加。如經丙基瓜 無法形後添加’則步驟增多而使成本増高， "、、占敷片。亦即，如羥丙基瓜爾膠係在形 321801 14 201034693 凝膠後而添加時，固體的羥丙基瓜爾膠難以均質地分散在 凝膠表面，例如：由於作成水溶液添加時亦為高黏度，因 而難以均質地分散。另外，為了形成低黏度而作成低濃度 之水溶液添加時，亦由於過剩之水而無法獲得所需求的特 性（使用性、效果感）。並且，無法均質地分散時，滲出液 之黏度不均，例如有部分易於剝離或保溼效果僅為局部性 等而無法獲得所需求之特性，因而不佳。 化粧品貼敷用凝膠片之製造方法，係例如在至少將合 成高分子0. 5至35重量份（以1至30重量份為佳，2至25 重量份更佳）與羥丙基瓜爾膠0. 05至3重量份（以0. 1至2 重量份為佳，0. 2至1重量份更佳）與濕潤劑1至30重量 份（以2至2 0重量份為佳）以及水混合而得的混合物中，再 添加交聯劑0. 1至5重量份（以0. 5至2重量份為佳）與作 為滲出劑的聚氧伸乙基曱基葡萄糖苷3至12重量份（以6 至12重量份為佳）並混合使之反應者。 其中，化粧品貼敷用凝膠片之製造方法，更佳者係添 加pH調整劑（酸觸媒）0. 1至10重量份（以1至F重量份為 佳）使混合溶液之pH值調整為4至7並使之反應者。 另外，水之總量以添加60至97重量份為佳，以70 至95重量份更佳。較佳者係先將上述水之一部分添加於交 聯劑與滲出劑之混合物中再作為混合溶液而添加。 [實施例] 以下，依實施例與比較例說明本發明，然而本發明並 不僅限於此。 15 321801 201034693 (實施例） 使用下表所示之凝膠形成用組成物，並依以下順序作 成化粧品貼敷片中所用之各實施例.比較例的凝膠片。在合 成高分子與羥丙基瓜爾膠（HP瓜爾膠）或其他增黏劑中添 加濕潤劑，再添加藥效成分以及水並充分攪拌混合至均勻 為止。 在該混合物中添加作為滲出劑之聚氧伸乙基曱基葡 萄糖苷，再添加交聯劑與水使充分分散而作成於漿，並在 該淤漿中添加pH調整劑（酸觸媒），合計作為100份，充分 地混合攪拌。其次，在平滑玻璃板上所置載38# m厚度的 PET膜（聚對苯二曱酸乙二酯）之四邊放置1mm厚度的間隔 板，將適量之上述組成物混合結束後使即刻流入其中央部 分，疊上單位面積重量17g/m2之尼龍針織布（半針織）與另 一片38/zm厚度的PE1T膜，再自其上以玻璃板夾住放置24 小時，得到厚度1匪之凝膠片。將該凝膠片裁成5cmx5cm 作為評估用試料。 16 321801 201034693[Technical Field] The present invention relates to a gel sheet for cosmetic application which is attached to a face, a wrist, a foot, and the like. More specifically, the present invention relates to a skin care gel patch using a hydrogel external preparation, [Prior Art] The gel patch for cosmetic application of the present invention is a hydrogel patch containing a large amount of water. External preparation. It is characterized in that water such as a medicinal ingredient is exuded to the surface of the gel by adding a small amount of a hydrophobic polyol, and a moisturizing effect or the like is obtained by penetration of water or the like on the adhered skin. Conventionally, Patent Document 1 relates to a sheet-like applicator characterized by containing a water-soluble polymer, a polyhydric alcohol, a moisturizing component, a crosslinking agent, a skin component, water, and the like as essential components. The water-soluble southern molecular system herein describes gelatin and polyacrylate. The effect of the high-water-containing sheet-like patching agent is to impart moderate adhesion and moisture retention to the skin, and not only the stability of the physical properties of the preparation and the safety of the skin, but also the feeling of use during use and the skin. Excellent effect on application. Patent Document 2 relates to a sheet-like patch for de-skin, characterized in that at least a layer of a hydrogel-like composition containing a polymer having a crosslinked carboxyl group and/or a salt thereof is provided on a support. On one side, the layer of the above aqueous gel-like composition further contains a polyol. The carboxyl group-containing polymer herein is described as polyacrylic acid, polymethacrylic acid, polyitaconic acid, alginic acid, carboxymethylcellulose, gelatin, pectin, carboxymethylhydroxyethylcellulose, methoxy group. An ethylene-maleic anhydride copolymer or the like. 4 321 801 201034693 Patent Document 3 relates to a sheet-like hydrogel which is a sheet-like hydrogel which is impregnated with a solution containing at least water, a surfactant and an oil component, and a solution exudation accelerator in a synthetic polymer having a mesh structure. Glue, and the solution exudation accelerator is a polymer comprising a glycol such as polyethylene glycol, polypropylene glycol or polyglycerin, or a polyol. [PATENT DOCUMENT] [Patent Document 1] Japanese Laid-Open Patent Publication No. JP-A-2002-183257 (Patent Document No. JP-A-2002-020257) [Invention] [Problems to be Solved by the Invention] However, since the original viscosity of water or the like exuded from the gel sheet, that is, the extremely low viscosity, is a dry touch, it is dripped in the clothes during use. The problem of the class (drip), and the feeling of adhesion during use, the feeling of fruitiness (moisturizing feeling) felt after use is not enough. In the publication of Patent Document 1, although a large amount of water is efficiently discharged to the outside during use, the concept of liquid oozing is introduced, but the state of the exudate is not considered, and thus the usability is used. The sense of use is not enough. Patent Document 2 relates to a sheet-like patch for removing sebum, which effectively removes excess sebum and dirt, and does not accompany pain when peeled off from the skin, and can remove excess sebum while replenishing moisturizing side. There is also no description of liquid exudation, etc., and it is insufficient in terms of moisturizing feeling and the like. 5 321 801 201034693 In this respect, Patent Document 3 uses a nonionic water-soluble rain molecule as described above as a solution oozing agent, and since it oozes a solution containing a medicinal ingredient or the like, the use effect is high. However, compared with glycerin, these nonionic water-soluble polymers have low moisture absorption. Therefore, in order to improve the moisture retention of the bleed solution, it is necessary to have a higher moisture absorption and function as a solution oozing agent. An object of the present invention is to provide a gel sheet for cosmetic application which is capable of reducing the oozing property of a solution from a surface of a gel and improving the moisturizing property of a solution which oozes, and at the same time, is easy to be dripped at the time of use. The problem of the so-called drooping property which falls on the clothes, and the feeling of the moisturizing feeling can be sufficiently obtained by permeating the adhered skin after the use of the sputum due to the feeling of closeness during use. [Means for Solving the Problem] As a result of intensive evaluation and review by the present inventors, it was found that a hydroxypropylated hydroxypropyl group of guar gum obtained from guar seeds of legumes was appropriately added. When guar gum and polyoxyethylene methyl glucoside as an exuding agent, the exudation property of the solution derived from the gel is not lowered, and the viscosity of the oozing solution is opened, and the drip property is improved and used. The feeling of ν' in the middle and the sense of effect (moisturizing feeling) felt after use can be noticeable. Thus, the present invention relates to a gel sheet for cosmetic application, which comprises a synthetic ruthenium molecule having a mesh structure J, a hydroxypropyl guar, a humectant, and a polyoxyethylene group as an exuding agent. The glucoside and the water are characterized in that the hydroxypropyl guar is contained in an amount of from 0.05 to 3 parts by weight, and the polyoxyethylidene ethyl glucoside is from 3 to 12 parts by weight in 100 parts by weight of the gel sheet. [Effect of the Invention] 321801 6 201034693 The gel sheet for cosmetic application of the present invention is as described above, and the composition thereof is at least contained in a gelled polymer having a mesh structure containing hydroxypropyl guar, impregnated a sheet-like hydrogel which oozes out an aqueous liquid on the surface of the gel, polyoxyethylidene methyl glucoside as an exuding agent for allowing the liquid to exude on the surface of the gel, and water, so that the solution from the gel is not caused The oozing property is lowered and the moisture retention property of the oozing solution is increased, and at the same time, the viscosity of the oozing solution is increased. 'Improved for the improvement of the sag, the feeling of closeness in use, and the feeling of feeling (moisturizing feeling) after use. effect. [Embodiment] (Synthetic Polymer) The synthetic polymer is not particularly limited as long as it can form a network structure and form a gel containing at least water. Hydrogels In the field of cosmetics, when used as a transdermal application, synthetic high molecular weights permitted in the art can be used. In particular, a synthetic polymer having hydrophilicity is used, and a synthetic polymer having an anionic functional group in the ear is also more suitable. Examples of the synthetic high-concentration C) include, for example, a polymer of a polymerizable unsaturated monomer such as acrylic acid or mercaptopropene having a carboxyl group as a functional group, and salts (for example, sodium salt, salt-removing, and second). An ethanolamine salt or the like); a polymer having a polymerizable unsaturated monomer such as a third butyl acrylamide-based acid having a functional group as a functional group; and a salt (for example, a sodium salt or a salt-removing salt). Preferably, the hydrophilicity is high, and the sodium polysodium carbonate is used. The preferred content is '0: 5 to 35 parts by weight in 100 parts by weight of the gel sheet. Further, the synthetic polymer before crosslinking may be partially crosslinked as long as it does not interfere with the production of the sheet-like hydrogel. Further, if considering the operability of 321801 7 201034693 at the time of manufacture, it is preferable to use a synthetic polymer having a weight average molecular weight of from 100,000 to 5,000,000 before crosslinking. (Crosslinking Agent) The network structure of the synthetic polymer can be obtained by crosslinking of the synthetic polymer before crosslinking. That is, a cross-linking agent is added to the synthetic polymer before cross-linking, and if necessary, it is heated to obtain a mesh structure. Examples of the crosslinking agent include, for example, hydrazine hydroxide, sulphate, sulphuric acid, aluminum sulphate, aluminum acetate, aluminum oxide, aluminum metasilicate, magnesium sulphate, calcium hydroxide, calcium carbonate, magnesium metasilicate Aluminum, polyethyleneimine, polyethylene glycol diglycidyl ether, glycerol triglycidyl bond, isocyanuric acid triglycidyl S. The content is preferably 0.1 to 5 parts by weight in 100 parts by weight of the gel sheet for cosmetic application. (pH adjuster) Adjusts the optimum pH for the action of the crosslinking agent. In addition to the α-hydroxy acid such as tartaric acid, lactic acid or glycolic acid, various organic acids such as citric acid can be used for the purpose of more reliable crosslinking. Or a mineral acid such as hydrochloric acid is used as a pH adjuster (acid catalyst). The content is preferably 0.1 to 10 parts by weight in 100 parts by weight of the gel sheet for cosmetic application. The gel sheet for cosmetic application of the present invention can also be colored by a pigment or the like, but it is preferably a transparent to almost transparent appearance. In the so-called transparent system of the present invention, when the gel sheet is placed on a white high-quality paper printed with black dots of 20 characters, it is preferable to ensure transparency with respect to the presence or absence of characters. In the gel sheet for cosmetic application of the present invention, in the non-destructive and transparent transparency of the gel sheet, 8 321 801 201034693 2, the tearing strength and the operability of the rotary film, the opening in the gel sheet = thickness direction It is better to have a large enough weaving or non-woven fabric. In the present invention, the woven fabric or the non-woven fabric having a large opening ratio means that the transparency can be maintained even if the large non-woven fabric has a large aperture ratio of 2G dot layout. ο 赈 赈 发 之 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 The thickness of the gel sheet for cosmetic application of the present invention can be accurately adhered to the desired portion, and the thickness of the gel sheet for cosmetic application can be different even if the overall sound level is different, in order to ensure adhesion, transparency and film The strength is weak, or exceeds Si Jiayu and there is insufficient adhesion. In addition, the weight of the whole piece of the condensate piece itself can be thickened to a part of the thickness of the gel sheet. Gum) Bean = propyl guar gum guar gum is a method for the guar wind and epoxy oxime reaction of the natural water-soluble polymer polysaccharides Non-ionic polymer obtained by propyl. Polysaccharide, guar gum, cationized guar fiber and other _ and its derivatives can enhance hydrogel 321801 9 201034693 can solve the problem of water retention of the gel itself When the temperature rises, there is a problem that the bleed out of the solution containing the chemical liquid component of the gel is suppressed. On the other hand, the point of the oozing solution does not rise and the original dry temperature feels, and the above-mentioned improvement effect is insufficient. The degree of substitution of the hydroxypropyl group in the guar gum is from 0.4 to 1.2. More preferably, the effect of the hydroxypropyl guar is from 0.05 to 3 parts by weight per 100 parts by weight of the cosmetic application gel sheet. When the amount of the gel tablet for cosmetic application is less than 0.05 parts by weight, the turbidity is not improved compared with the case without hydroxypropyl guar, and the feeling of adhesion during use is lowered, and the feeling after use is reduced. The moisturizing sensation is also reduced. When the content of the hydroxypropyl guar is more than 3 parts by weight in one part by weight of the coated gel sheet, a strong sticky feeling is generated, so that it is used. The feeling of use is not deteriorated. Preferably, the hydroxypropyl guar gum is contained in an amount of from 0.1 to 2 parts by weight per part by weight of the gel sheet for cosmetic application, and most preferably from 〇2 to ! parts by weight. Exudate) The surface is effectively converted out of the hydrogel formulation. The species is both hydrophilic: it is also called a solution extraction promoter. For example, by adjusting the hydrophobicity of the hydrogel: === degree Substance, ie, the base Si:: non-ionic water-soluble polymer, using polyoxyethylene, polyoxyethylene, ethylene, and its pots - 1 part by weight a toughening glycoside is 3 to 12 parts by weight in the gel sheet 3 for cosmetic application. Polyoxyethylene methyl ethyl 321801 10 201034693 y glycoside is less than 3 weights in 100 parts by weight of the cosmetic application gel sheet When it is used, it is not preferable because the amount of exudation is too large, and the amount of exudation is too large when the polyoxyethylidene ethyl glucoside exceeds 12 parts by weight in 100 parts by weight of the gel sheet for cosmetic application. The turbulence is poor, and the range is preferably 6 to parts by weight. The polyoxyethylidene glucoside is a nonionic water-soluble solution having a moisture absorption rate of 70 when the glycerin has a moisture absorption of 1 Torr. Molecules. The non-zero ionic water-soluble polymer with a large moisture absorption rate has a large water retention capacity, but has the ability to cause the solution in the hydrogel to ooze out of the surface of the hydrogel, and to improve the moist feeling of the oozing solution and to protect Wet effect. (Humectant) Examples of the humectant include ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, glycerin, diglycerin, isopropyl glycol, 1,3-butylene glycol, and sorbitol. , various derivatives such as maltitol, trehalose, raffinose, xylitol, mannitol, hyaluronic acid and its salts, trehalose and raffinose, trimethylglycine, cyclodextrin, hyaluronic acid and Glycols such as salts, polyols, and polysaccharides. These may be used alone or in combination of two or more. The content of the moisturizing agent is preferably from 1 to 30 parts by weight based on 100 parts by weight of the gel sheet for cosmetic application. (Pharmaceutical component) The medicinal component which can be adjusted in the present invention is not particularly limited as long as it is a user of a conventional pharmaceutical, a quasi drug, a cosmetic, a sanitary material, or a miscellaneous product, and examples thereof include, for example, : Tomorrow Leaf Extract, Case Sheath Extract, Sweet Tea Extract, Medicinal Sunflower Extract, Arnica Extract, Mountain 11 321801 201034693 Apricot Extract, Apricot Kernel Extract, Cumin Extract, Turmeric Extract, Oolong Tea Extract , Echinacea leaf extract, Astragalus extract, Cortex extract, Barley extract, Dutch mustard extract, citrus extract, seawater dry, hydrolyzed elastin, hydrolyzed wheat powder extract, hydrolyzed milk extract, chamomile extract , carrot extract, Artemisia argyi extract, licorice extract, Roselle extract, kiwi extract, quinine extract, small yellow claw extract, guanosine, white bamboo extract, walnut extract, Grapefruit extract, clematis extract, yeast extract, burdock extract, comfrey extract, collagen, cranberry extract, Bupleurum Extract, umbilical cord extract, red extract, saponin extract, bamboo extract, wild scorpion (Crataegus cuneata) extract, extract of scent extract, rehmannia extract, purple root extract, extract of East China sorghum Spiraea extract, calamus root extract, birch extract, squid extract, honeysuckle extract, ivy extract, Crataegus oxyacantha extract, black elderberry extract (Bleak elder) extract, artichoke Grass extract, peppermint extract, mallow extract, jujube extract, thyme extract, clove extract, whitegrass extract, dried tangerine peel extract, bitter orange peel extract, houttuynia extract, tomato extract , natto extract, amaranth extract, wild rose extract, hibiscus extract, meringue extract, parsley extract, honey, medicinal wall extract, blue musk tea extract, myrrh Alcohol Extract, Coltsfoot Dandelion Extract, Butterflies Extract, Quinoa Extract, Leaf Tree Extract, Grape Extract, Propolis Extract, Loofah Extract, Peppermint Extract, Tree Extract , Rosin 彳t* extract, pine bark extract, horse chestnut extract, water banana extract, sapindus extract, peach extract, cornflower extract 12 321801 201034693, eucalyptus extract, fragrant extract , wormwood extract, lavender extract, apple extract, lettuce extract, lemon extract, milk vetch extract, scorpion flower extract, rosemary extract, Roman chamomile extract, royal jelly extract, etc. Also mentioned are: biopolymers such as deoxyribonucleic acid, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membrane, etc.; amino acid, urea, pyrrole Moisturizing ingredients such as sodium ketone ketone, sweet lycopene, whey, trimethylglycine; oily components such as sphingolipid, neuropterin, cholesterol, cholesterol derivatives, phospholipids; ε_ aminocaproic acid , anti-inflammatory agents such as glycyrrhizic acid, 0-glycyrrhetinic acid, gasified lysozyme, guaiac blue fume, cortisol; vitamin A, vitamin beta, vitamin Β 6, vitamin D, vitamin E, calcium pantothenate, biotin, nicotine Vitamins such as indoleamine; active ingredients such as allantoin, diisopropylamine dichloroacetate, 4-aminomercaptocyclohexanecarboxylic acid, fertility, carotenoids, flavonoids, tannins, and wood ages (1 Ignan), saponin and other antioxidants; r - rice cyclamate, vitamin e derived sputum and other blood circulation promoters; retinol alcohol, retinol alcohol derivatives and other wound sore mixture; head flower ginseng, capsicum, eucalyptus , iodine-containing garlic essence, pyridoxine hydrochloride, (Π -α-tocopherol, dl-α tocopheryl acetate, nicotinic acid, nicotinic acid derivative, calcium pantothenate, D-panthenol, ethyl ethoxide ethyl ether, biotin, allantoin, isopropyl Methyl group test, although diol, B., although alcohol, Carpronium Chloride, benzalkonium chloride, Diphenhydramine Hydrochloride, photoreceptor (Takanal), Camphor, Salicylic Acid, Vanillyl Citrate, Erythroline Ethanolamine Salt, Fifteen 321801 201034693 Sour Glycerin, Mononitrogenate, Wood, Benzene, and Amino Acid, benzethonium chloride, Mexiletine Hydrochloride, auxin, estrogen, Cantharides tincture, cyclosporin, hydrogenated steroid Hydrocotisone, polyoxyethylene ethyl sorbitan monostearate, analgesic, neuroleptic, hypotensive agent, antibiotic, antihistamine, antibacterial substance, etc. The material and the amount of the active ingredient are different and cannot be uniformly defined. The quality of the gel sheet for cosmetic application is preferably from 0.05 to 30% by mass. (Manufacturing method) For example, at least a synthetic polymer, hydroxypropyl guar, or the like may be used. a mixture of wet _ and water mixed with a cross-linking agent, which is a polyoxyethylidene glucoside as a reference agent, which is mixed and allowed to react. A preferred manufacturing method can be employed, and its characteristics are characterized. Department: Add Qiu adjuster (acid catalyst) to adjust the pH value of the mixed solution to 4 to 7 and reverse it. The most important one is to add (4) base melon to the synthetic sizing agent to make propyl guar. After dissolving, the point of the polyoxyalkylene-ethylmethylglucose bud of the cross-linking agent-extracting agent is further added. In other words, the methyl glucoside is liquid at room temperature without problems, and the gum: gel is added before the gel is formed. If the propyl melon can not be added after the addition, then the steps increase and the cost is high, ",, accounted for the patch. That is, when the hydroxypropyl guar gum is added after the gel of the shape of 321801 14 201034693, the solid hydroxypropyl guar is difficult to uniformly disperse on the surface of the gel, for example, it is also high when added as an aqueous solution. Viscosity, and thus difficult to disperse homogeneously. Further, in order to form a low-concentration aqueous solution in order to form a low viscosity, the required characteristics (usability, effect feeling) cannot be obtained due to excess water. Further, when it is not uniformly dispersed, the viscosity of the exudate is not uniform, and for example, some of them are easily peeled off or the moisturizing effect is only local, and the desired characteristics are not obtained, which is not preferable. The method for producing a gel sheet for cosmetic application is, for example, at least 0.5 to 35 parts by weight of the synthetic polymer (preferably 1 to 30 parts by weight, more preferably 2 to 25 parts by weight) and hydroxypropyl guar. 0. 05 to 3 parts by weight (preferably 0.1 to 2 parts by weight, more preferably 0.2 to 1 part by weight) and 1 to 30 parts by weight of the humectant (preferably 2 to 20 parts by weight) and 1 to 5 parts by weight (preferably 0.5 to 2 parts by weight) and polyoxyethylidene glucoside as an exuding agent 3 to 12 parts by weight. Parts (preferably 6 to 12 parts by weight) and mixed to make the reaction. Wherein, the method for producing a gel sheet for cosmetic application, more preferably adding a pH adjuster (acid catalyst) 0.1 to 10 parts by weight (preferably 1 to F parts by weight) to adjust the pH of the mixed solution It is 4 to 7 and reacts to it. Further, the total amount of water is preferably 60 to 97 parts by weight, more preferably 70 to 95 parts by weight. Preferably, one part of the above water is added to the mixture of the crosslinking agent and the exuding agent and then added as a mixed solution. [Examples] Hereinafter, the present invention will be described by way of Examples and Comparative Examples, but the present invention is not limited thereto. 15 321801 201034693 (Example) The gel-forming composition shown in the following table was used, and the gel sheets of the respective examples and comparative examples used in the cosmetic patch were prepared in the following order. Add a wetting agent to the synthetic polymer and hydroxypropyl guar (HP guar) or other tackifier, add the medicinal ingredient and water, and mix well until it is even. Adding polyoxyethylidene glucoside as an exuding agent to the mixture, adding a crosslinking agent and water to sufficiently disperse the slurry, and adding a pH adjuster (acid catalyst) to the slurry. In total, as 100 parts, the mixture was thoroughly mixed and stirred. Next, a spacer film having a thickness of 1 mm was placed on four sides of a 38# m thick PET film (polyethylene terephthalate) on a smooth glass plate, and an appropriate amount of the above composition was mixed to immediately flow into the film. In the central part, a nylon knitted fabric (half knitting) having a weight per unit area of 17 g/m2 and another PE1T film having a thickness of 38/zm were stacked, and then placed on the glass plate for 24 hours to obtain a gel having a thickness of 1 匪. sheet. The gel piece was cut into 5 cm x 5 cm as a sample for evaluation. 16 321801 201034693
I-1 T-li 表 I_II-1 T-li Table I_I
Q (每¥制) 比較例 03 ΓΊ 〇〇 — o.oi I 〇 ΓΝ o Ό 1 7U 1 SO V〇 rq 00 -9· Ρ-4 00 fn *ri d rs 气 so I 66.2 ο s o 卜 Γ4 〇e 寸 fO Ο m Ο ο «Ν o 'ύ | 70.9 QO o v〇 (D ΓΊ 00 寸 r**> d m d 5 CN SO I 70.9 〇> η OS s〇 s to ΓΊ 00 *«r m Ο ο η NO I 70.9 卜 PM fi 00 n m m O' Μ 00 Φ m ο ΓΜ o so I 70.9 s R s η fsl 00 f*\ o f*\ d ο es o VO I 70.9 s t*> s CM oo — 寸 P〇 r»*i 〇 ο ts w> 1 61.9 二 s w <N 00 TT Γ7 rn ο ΓΊ o 1 76,9 rn 90 r- 口 實施例 ΙΟ «S eo «Μ ΓΛ C> m ο fN ^r o SO I_68.2 〇> 芬 o* m Ιβ rf <M 00 一 ΓΟ 0.05 J ο <N v〇 1 71.2 1 m ON m 〇 ro 寸 r* 00 _ 寸 m ο «Ν IN | 64.9 说 s 00 m CO ao rn «η ο d m 1 73.9 00 n P； «〇 OJ n \〇 Μ 〇 rn I 0.05 I ν> <rt 00 167Λ rj 〇» A — n 00 m O ο iS o Ό I_70.9 o r*% 聚丙烯酸鈞 1 酒石酸 | 二丙二醉 1 甘油 1 二甘油 1 乙酵 1 eo o ftsi s-/ ΙΟ o — Cu X 瓜爾膠 1 陽離子化瓜爾膠 l 1黃原膠 丨 1羥乙基織維素 | 1玻尿酸鈉 1 r-\ \ Ί W 蚌 φτ 'w* Q ϋ ii 赛 a O (/) < | KOH (氩氧化鉀） 1 5 〇 (0 ϋ α. SM *sc 驪 m * 回 # 趔 |植物固酵油酸酯 | |偏矽酸鎂鋁 I « m ¢- Ο /-Ν 審 CO 1= 1離子交換水 丨滲出量(X/10分•凝膠重量） |垂流性 1緊密性 丨保濕感 Φ 踩 X α Ψ c Γ i | HP瓜爾膠 1 增黏劑 轎效成分 1 交聯剤 滲出劑 評估 17 321801 201034693 由凝膠片所滲出液體的滲出量係如下測定。 凝膠片係在測定前一刻由袋中取出並剝下雙面之PET 膜，測定重量（a)後，僅在單面貼附PET膜。預備2片玻璃 板（100\10〇111111厚度3111111)與滤紙（人(^81^6〇公司製造之5八 直徑150mm圓形），測定濾紙重量（b)並置於1片玻璃板 上。在濾紙之中央部使凝膠面朝下貼上凝膠片，於其上亦 置載1片玻璃板並靜置10分鐘。然後，拿掉玻璃板與凝膠 片上之PET膜，再去除凝膠並僅測定圓形濾紙之重量（c)， 從與預先測定之濾紙重量的差算出滲出液之重量。將該液 量作為以相對於原有凝膠重量之比例表示之滲出量 ((c-b)/a)。測定值係使用3片凝膠進行相同試驗之結果的 平均值。由於滲出量過少時降低對肌膚的密著性，在使用 中易於剝落，且對皮膚的滲透量亦少，因此保溼感等效果 不足，過大時則因凝膠之重量而發生偏移掉落，且過剩液 體垂流（垂液）而附著於衣物等，因此滲出量之較佳範圍為 20 至 35(%)。 作為[貼敷劑之評估] 將上述所形成之凝膠片貼附在上半身坐直狀態之10 名女性受驗者之臉頰，將靜置20分鐘時之密著性以及垂流 性之評估，與20分鐘後剝離後之肌膚狀態之保溼感以下述 1至5之5階段表現，評估作為貼敷劑之使用性及效果感， 並將所有受驗者之合計點數作為評估結果。因此’該等評 估值係表示性能與效果之大小（滿分50點）。將其結果呈示 於表中。 18 321801 201034693 效果感（保溼感）評估 5 ··感覺到肌膚有明顯的保澄。 ^ 4:感覺到肌膚有保溼。 3 :感覺到肌膚有些保溼。 2:感覺到肌膚僅有些微保溼。 1 :感覺不到效果。 使用性C垂流性）評估 5:毫無垂流性。 〇 4:僅有些微垂流性。 3:有些垂流性。 2 :垂流性多。 1 :垂流性過多，所滲出之液甚至沾附到衣物的程度。 使用性（密著性）評估 5:完全與肌膚密著而無偏移。 4 :幾乎與肌膚密著，僅有些許偏移。 Ο 3:存在著不與肌膚密著之部分而有些偏移。 2 :難與脱膚密著，偏移多。 1 :偏移過大而掉落。 由表1可知，不論藥效成分為水性或油性，實施例1 至6之凝膠片，相較於無添加聚氧伸乙基曱基葡萄糖苷之 比較例1，係滲出量適度且使用性（垂流性、密著性）、效 果感（保溼感）優異者。相對於化粧品貼敷用凝膠片100重 量份，聚氧伸乙基甲基葡萄糖苷為15重量份的比較例2， 由於聚氧伸乙基曱基葡萄糖普過多而使滲出量過剩，因此 19 321801 201034693 在垂流性、密著性方面不足。 以作為其他增黏劑之瓜爾膠、陽離子化瓜爾膠、黃原 膠、經乙基纖維素取代經丙基瓜爾膠之比較例3至6，滲 出量雖適度，但垂流性、密著性不足，且保溼感不足。並 且，以玻尿酸鈉作為其他增黏劑之比較例7，垂流性雖佳， 但滲出量不足，密著性降低且保溼感不足。 相對於化粧品貼敷用凝膠片100重量份，HP瓜爾膠超 出3重量份的比較例8，呈現強烈的黏著感，使用時之使 用感惡化。相對於化粧品貼敷用凝膠片100重量份，HP瓜 爾膠未達0.05重量份的比較例9，由於HP瓜爾膠過少， 滲出量雖適度，但垂流性、密著性不充分使得效果感不足。 [產業上之可利用性] 本發明可使用作為貼附在顏面、腕臂、足部等之化粧 品貼敷用凝膠片，可用於作用使用水凝膠外用劑之護膚用 凝膠貼敷片。 【圖式簡單說明】無 【主要元件符號說明】無 20 321801Q (per ¥) Comparative Example 03 ΓΊ 〇〇 — o.oi I 〇ΓΝ o Ό 1 7U 1 SO V〇rq 00 -9· Ρ-4 00 fn *ri d rs Gas so I 66.2 ο so Γ 4 〇 e inch fO Ο m Ο ο «Ν o 'ύ | 70.9 QO ov〇(D ΓΊ 00 inch r**> dmd 5 CN SO I 70.9 〇> η OS s〇s to ΓΊ 00 *«rm Ο ο η NO I 70.9 卜 PM fi 00 nmm O' Μ 00 Φ m ο ΓΜ o so I 70.9 s R s η fsl 00 f*\ of*\ d ο es o VO I 70.9 st*> s CM oo — inch P〇 r»*i 〇ο ts w> 1 61.9 2 sw <N 00 TT Γ7 rn ο ΓΊ o 1 76,9 rn 90 r- Port Example ΙΟ «S eo «Μ ΓΛ C> m ο fN ^ro SO I_68 .2 〇> 芬o* m Ιβ rf <M 00 ΓΟ 0.05 J ο <N v〇1 71.2 1 m ON m 〇ro rr* 00 _ inch m ο «Ν IN | 64.9 say s 00 m CO ao rn «η ο dm 1 73.9 00 n P; «〇OJ n \〇Μ 〇rn I 0.05 I ν> ≪rt 00 167Λ rj 〇» A — n 00 m O ο iS o Ό I_70.9 or*% polyacrylic acid 钧1 tartaric acid | dipropylene two drunk 1 glycerol 1 diglycerol 1 ethyl yeast 1 eo o ftsi s-/ ΙΟ o — Cu X guar 1 cationized guar l 1 xanthan gum 羟 1 hydroxyethyl woven vitamin | 1 sodium hyaluronate 1 r-\ \ Ί W 蚌φτ 'w* Q ϋ ii race a O (/ < | KOH (potassium argon) 1 5 〇 (0 ϋ α. SM *sc 骊m * back # 趔 | plant solidification oleate | | magnesium metasilicate magnesium I « m ¢- Ο /-Ν CO 1 = 1 ion exchanged water oozing exudation (X/10 points • gel weight) | drooling 1 tightness 丨 moisturizing Φ step X α Ψ c Γ i | HP guar 1 sticky agent car effect Ingredient 1 Cross-linking exudate evaluation 17 321801 201034693 The amount of exudation of the liquid exuded from the gel sheet was determined as follows. The gel sheet was taken out from the bag immediately before the measurement and the double-sided PET film was peeled off, and after measuring the weight (a), the PET film was attached only to one side. Prepare two glass plates (100\10〇111111 thickness 3111111) and filter paper (man (manufactured by the company), the weight of the filter paper (b) is measured and placed on a glass plate. In the center of the filter paper, the gel is placed face down on the gel sheet, and one glass plate is placed thereon and allowed to stand for 10 minutes. Then, the PET film on the glass plate and the gel sheet is removed, and the gel is removed. Only the weight (c) of the circular filter paper is measured, and the weight of the exudate is calculated from the difference from the weight of the filter paper measured in advance. The amount of the liquid is taken as the amount of exudation expressed in proportion to the weight of the original gel ((cb) /a). The measured value is the average value of the results of the same test using three gels. When the amount of exudation is too small, the adhesion to the skin is lowered, and it is easy to peel off during use, and the amount of penetration into the skin is small. The effect of moisturizing is insufficient, and when it is too large, the weight of the gel is shifted and dropped, and excessive liquid sag (dip liquid) adheres to the clothes, etc., so the exudation amount is preferably in the range of 20 to 35 (%) As the evaluation of the patch, the gel sheet formed above is attached to the upper half. The cheeks of 10 female subjects in a straight state will be evaluated for the adhesion and sag of the 20-minute rest, and the moisturizing feeling of the skin after peeling after 20 minutes is 1 to 5 below. Stage performance, evaluation as the use and effect of the patch, and the total points of all subjects as the evaluation results. Therefore, 'the evaluation value is the performance and effect size (out of 50 points). The results are shown in the table. 18 321801 201034693 Effect (moisturizing) evaluation 5 ··Feel the skin with a clear preservation. ^ 4: Feel the skin moisturizing. 3 : Feel the skin moisturizing. 2: I feel that the skin is only slightly moisturized. 1 : I can't feel the effect. The use of C drip) evaluation 5: no drooping. 〇 4: Only slightly sag. 3: Some drooling. 2: More drooling. 1 : Excessive drooling, the degree of oozing liquid even adheres to clothing. Usability (adhesion) evaluation 5: Completely adhered to the skin without offset. 4: Almost the skin is tight, only a little offset. Ο 3: There is a slight offset from the skin. 2: It is difficult to get rid of the skin and the offset is much. 1 : The offset is too large and falls. As can be seen from Table 1, the gel tablets of Examples 1 to 6 were compared with Comparative Example 1 without addition of polyoxyethylidene glucoside, regardless of whether the medicinal component was aqueous or oily, and the amount of exudation was moderate and usable. (drip, adhesion), effect (moisturizing) is excellent. In Comparative Example 2 in which the polyoxyethylidene ethyl glucoside was 15 parts by weight with respect to 100 parts by weight of the gel sheet for cosmetic application, the amount of exudation was excessive due to excessive polyoxyethylidene glucoside, so 19 321801 201034693 Insufficient in terms of sag and adhesion. Comparative examples 3 to 6 of guar gum, cationized guar gum, xanthan gum, and ethyl cellulose substituted with propyl guar as other tackifiers, although the amount of exudation was moderate, but the sag, Insufficient adhesion and insufficient moisturizing feeling. Further, in Comparative Example 7 in which sodium hyaluronate was used as another tackifier, the drooping property was good, but the amount of bleeding was insufficient, the adhesion was lowered, and the moisturizing feeling was insufficient. In Comparative Example 8 in which the HP guar gum exceeded 3 parts by weight, 100 parts by weight of the gel sheet for cosmetic application showed a strong adhesive feeling, and the feeling of use at the time of use deteriorated. Compared with 100 parts by weight of the gel sheet for cosmetic application, the HP guar was less than 0.05 part by weight of Comparative Example 9. Since the amount of HP guar was too small, the amount of exudation was moderate, but the drooping property and the adhesion were insufficient. Insufficient effect. [Industrial Applicability] The present invention can be used as a gel sheet for cosmetic application which is attached to a face, a wrist, a foot, or the like, and can be used for a skin care gel patch for using a hydrogel external preparation. . [Simple diagram description] None [Main component symbol description] None 20 321801