TWI453035B - Gel sheet for cosmetic patching - Google Patents
Gel sheet for cosmetic patching Download PDFInfo
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- TWI453035B TWI453035B TW099105129A TW99105129A TWI453035B TW I453035 B TWI453035 B TW I453035B TW 099105129 A TW099105129 A TW 099105129A TW 99105129 A TW99105129 A TW 99105129A TW I453035 B TWI453035 B TW I453035B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Description
本發明係有關一種貼附在顏面、腕臂、足部等之化粧品貼敷用凝膠片。更詳言之,係有關一種使用水凝膠外用劑之護膚用凝膠貼敷片,The present invention relates to a gel sheet for cosmetic application which is attached to a face, a wrist, a foot, and the like. More specifically, it relates to a skin care gel patch for using a hydrogel external preparation.
本發明之化粧品貼敷用凝膠片係一種含有大量水之水凝膠貼敷材的外用劑。其特徵係經由添加少許的疏水性多元醇而使內含藥效成分等之水滲出至凝膠表面,並藉由水等對所貼附之皮膚的滲透而可得到保濕效果等。The gel sheet for cosmetic application of the present invention is an external preparation for a hydrogel patch containing a large amount of water. It is characterized in that water such as a medicinal ingredient is exuded to the surface of the gel by adding a small amount of a hydrophobic polyol, and a moisturizing effect or the like is obtained by penetration of water or the like on the adhered skin.
以往,專利文獻1係有關一種片狀貼敷劑,其特徵係包含作為必要成分之水溶性高分子、多元醇、保濕成分、交聯劑、美肌成分以及水等。此處之水溶性高分子係記載明膠、聚丙烯酸鹽。該高含水的片狀貼敷劑之效果係對肌膚持有適度的黏著性及保溼性,不僅製劑物性之安定性及對肌膚安全性優異,同時,在使用時之使用感以及對肌膚之貼敷效果優異。Conventionally, Patent Document 1 relates to a sheet-like applicator characterized in that it contains a water-soluble polymer, a polyhydric alcohol, a moisturizing component, a crosslinking agent, a skin component, water, and the like as essential components. Here, the water-soluble polymer is a gelatin or a polyacrylate. The effect of the high-water-containing sheet-like patching agent is to impart moderate adhesion and moisture retention to the skin, and not only the stability of the physical properties of the preparation and the safety of the skin, but also the feeling of use during use and the skin. Excellent effect on application.
專利文獻2係有關一種去皮脂用片狀貼敷劑,其特徵係包含將含有經交聯之羧基的聚合物及/或其鹽之含水性凝膠狀組成物之層設在支撐體的至少一面,而上述含水性凝膠狀組成物之層更含有多元醇者。此處之含羧基的聚合物係記載有聚丙烯酸、聚甲基丙烯酸、聚衣康酸、海藻酸、羧甲基纖維素、明膠、果膠、羧甲基羥乙基纖維素、甲氧基乙烯-順丁烯二酐共聚物等。Patent Document 2 relates to a sheet-like patch for de-skin, characterized in that at least a layer of a hydrogel-like composition containing a polymer having a crosslinked carboxyl group and/or a salt thereof is provided on a support. On one side, the layer of the above aqueous gel-like composition further contains a polyol. The carboxyl group-containing polymer herein is described as polyacrylic acid, polymethacrylic acid, polyitaconic acid, alginic acid, carboxymethylcellulose, gelatin, pectin, carboxymethylhydroxyethylcellulose, methoxy group. An ethylene-maleic anhydride copolymer or the like.
專利文獻3係有關一種片狀含水凝膠,其係於具有網眼構造之合成高分子中含浸至少包含水、界面活性劑以及油性成分之溶液與溶液滲出促進劑的片狀含水凝膠,而該溶液滲出促進劑係包含聚乙二醇、聚丙二醇、聚甘油等二醇、多元醇等的聚合物者。Patent Document 3 relates to a sheet-like hydrogel which is a sheet-like hydrogel in which a synthetic polymer having a mesh structure is impregnated with a solution containing at least water, a surfactant, and an oil component, and a solution exudation accelerator, and The solution oozing accelerator is a polymer containing a glycol such as polyethylene glycol, polypropylene glycol or polyglycerin, or a polyol.
[專利文獻1]日本特開平08-188527號公報[Patent Document 1] Japanese Laid-Open Patent Publication No. 08-188527
[專利文獻2]日本特開2002-020257號公報[Patent Document 2] Japanese Patent Laid-Open Publication No. 2002-020257
[專利文獻3]日本特開2003-183147號公報[Patent Document 3] Japanese Patent Laid-Open Publication No. 2003-183147
然而,由於自凝膠片滲出之水等的原本黏度,亦即,極低的黏度而為乾澀觸感,因而有在使用時滴落在衣物類之問題(垂流性),且使用中的密著感,使用後所感覺的效果感(保濕感)並不足。However, due to the original viscosity of the water exuded from the gel sheet, that is, the extremely low viscosity and the dry touch, there is a problem of dripping on the clothes during use (drainage), and in use. The feeling of adhesion and the feeling of the feeling (moisturizing feeling) felt after use are insufficient.
在專利文獻1之公報中,雖有在使用時將較多量的水有效率地排至外部之記載,然而,雖導入液體滲出之概念,惟並未考量滲出液之狀態等,因而在使用性、使用感方面並不足。In the publication of Patent Document 1, although a large amount of water is efficiently discharged to the outside during use, the concept of liquid oozing is introduced, but the state of the exudate is not considered, and thus the usability is used. The sense of use is not enough.
專利文獻2係有關一種去皮脂用片狀貼敷劑,係有效地去除多餘的皮脂及污垢,同時在由皮膚剝離時不會伴隨著痛楚,更可一面補充滋潤一面僅去除多餘的皮脂,然而亦無液體滲出等之記載,特別在保溼感等方面不足。Patent Document 2 relates to a sheet-like patch for removing sebum, which effectively removes excess sebum and dirt, and does not accompany pain when peeled off from the skin, and can remove excess sebum while replenishing moisturizing side. There is also no description of liquid exudation, etc., and it is insufficient in terms of moisturizing feeling and the like.
在此方面,專利文獻3係使用如上述之非離子性水溶性高分子作為溶液滲出劑,由於滲出含有藥效成分等之溶液,因此使用效果較高。然而,相較於甘油,該等非離子性水溶性高分子之吸濕度較低,因此為了提高滲出溶液之保濕性,需有吸濕度更高且發揮溶液滲出劑作用者。In this regard, Patent Document 3 uses the above-described nonionic water-soluble polymer as a solution oozing agent, and has a high use effect because it oozes a solution containing a medicinal ingredient or the like. However, compared with glycerin, the nonionic water-soluble polymer has a low moisture absorption. Therefore, in order to improve the moisture retention of the oozing solution, it is necessary to have a higher moisture absorption and function as a solution oozing agent.
本發明之課題係提供一種化粧品貼敷用凝膠片,該凝膠片係在不使來自凝膠表面之溶液的滲出性降低且提高滲出之溶液的保濕性下,同時解決在使用時容易滴落在衣物上之所謂的垂流性之問題,且由於使用中之密著感,以及使用後,水分等滲透至經貼付的皮膚而可充分地得到效果感(保濕感)。An object of the present invention is to provide a gel sheet for cosmetic application which is capable of reducing the oozing property of a solution from a surface of a gel and improving the moisturizing property of a solution which oozes, and at the same time, is easy to be dripped at the time of use. The so-called drooping problem that falls on the clothes is sufficient to give a feeling of effect (moisturizing feeling) due to the feeling of adhesion during use and the penetration of moisture or the like into the applied skin after use.
本發明者等專心致志並進行檢討之結果發現,適量地添加取自豆科植物之瓜爾豆種子的瓜爾膠(guar gum)經羥丙基化之羥丙基瓜爾豆膠、與作為滲出劑之聚氧伸乙基甲基葡萄糖苷時,則來自凝膠之溶液的滲出性不會降低,且滲出溶液之黏度上升,對於垂流性之改善、使用中之密著感以及使用後感受到的效果感(保濕感)可得到明顯效果。As a result of intensive evaluation and review by the present inventors, it was found that guar gum of guar gum seeds obtained from legumes was hydroxypropylated with hydroxypropyl guar gum and as exudation. When the polyoxyethylene ethylglycoside is added, the exudation property of the solution derived from the gel is not lowered, and the viscosity of the exudation solution is increased, and the improvement of the sag, the feeling of intimacy in use, and the feeling after use The sense of effect (moisturizing feeling) can be noticeable.
如此,本發明係有關一種化粧品貼敷用凝膠片,係至少包含具有網眼構造之合成高分子、羥丙基瓜爾膠、濕潤劑、作為滲出劑之聚氧伸乙基甲基葡萄糖苷以及水者,其特徵係:在凝膠片100重量份中含有羥丙基瓜爾膠0.05至3重量份、聚氧伸乙基甲基葡萄糖苷3至12重量份。Thus, the present invention relates to a gel sheet for cosmetic application comprising at least a synthetic polymer having a mesh structure, a hydroxypropyl guar, a wetting agent, and a polyoxyethylidene methyl glucoside as an exuding agent. And the water is characterized in that it contains 0.05 to 3 parts by weight of hydroxypropyl guar and 3 to 12 parts by weight of polyoxyethylidene glucoside in 100 parts by weight of the gel sheet.
本發明之化粧品貼敷用凝膠片係如上所述,由於其構成係至少包含:於包含羥丙基瓜爾膠之具有網眼構造的合成高分子中,含浸滲出凝膠體表面之水性液體的片狀水凝膠、作為使上述液體滲出凝膠體表面之滲出劑的聚氧伸乙基甲基葡萄糖苷、以及水,因而不會使來自凝膠之溶液的滲出性降低並且提高滲出溶液之保溼性,同時,所滲出溶液之黏度上升,對於垂流性之改善、使用中之密著感以及使用後感受到的效果感(保濕感)可得到明顯效果。The gel sheet for cosmetic application of the present invention is as described above, and the composition thereof comprises at least: an aqueous liquid impregnated on the surface of the gel body in a synthetic polymer having a mesh structure comprising hydroxypropyl guar gum. a sheet-like hydrogel, polyoxyethylidene methyl glucoside as an exuding agent for allowing the liquid to exude on the surface of the gel, and water, thereby not lowering the exudation property of the solution derived from the gel and increasing the exudation solution The moisturizing property, at the same time, the viscosity of the oozing solution is increased, and the effect of the drooping property, the feeling of intimacy in use, and the feeling of feeling (moisturizing feeling) felt after use can be obtained.
(合成高分子)(synthetic polymer)
合成高分子如為可形成網眼構造並形成至少含有水之凝膠者即可,而無特別限制。水凝膠在化粧品的領域中作為經皮用途使用時,可使用該領域中所容許之合成高分子。特別是使用具有親水性之合成高分子,然其中亦以具有陰離子性官能基之合成高分子更適用。如此之合成高分子之例可列舉如:具有羧基作為官能基之丙烯酸、甲基丙烯酸等聚合性不飽和單體之聚合物以及該等之鹽(例如鈉鹽、鉀鹽、三乙醇胺鹽等);具有磺基作為官能基之第三丁基丙烯醯胺磺酸等聚合性不飽和單體的聚合物以及該等之鹽(例如鈉鹽、鉀鹽等)。較佳之親水性高分子可使用聚丙烯酸鈉。較佳含量係在凝膠片100重量份中含有0.5至35重量份。The synthetic polymer is not particularly limited as long as it can form a mesh structure and form a gel containing at least water. When the hydrogel is used as a transdermal application in the field of cosmetics, a synthetic polymer permitted in the field can be used. In particular, a synthetic polymer having hydrophilicity is used, and among them, a synthetic polymer having an anionic functional group is also more suitable. Examples of the synthetic polymer include a polymer having a carboxyl group as a functional group, a polymerizable unsaturated monomer such as methacrylic acid, and the like (for example, a sodium salt, a potassium salt or a triethanolamine salt). A polymer of a polymerizable unsaturated monomer such as a third butyl acrylamide sulfonate having a sulfo group as a functional group, and a salt (for example, a sodium salt or a potassium salt). A preferred polyhydric polymer can be sodium polyacrylate. The preferred content is 0.5 to 35 parts by weight in 100 parts by weight of the gel sheet.
另外,交聯前之合成高分子只要不妨礙片狀水凝膠之製造,且可進行部分交聯者即可。並且,如考量製造時之操作性,則宜使用重量平均分子量範圍在10萬至500萬之交聯前的合成高分子。Further, the synthetic polymer before crosslinking may be partially crosslinked as long as it does not interfere with the production of the sheet-like hydrogel. Further, in consideration of the workability at the time of production, it is preferred to use a synthetic polymer having a weight average molecular weight of from 100,000 to 5,000,000 before crosslinking.
(交聯劑)(crosslinking agent)
合成高分子之網眼構造可經由交聯前之合成高分子的交聯而得。亦即,在交聯前之合成高分子中添加交聯劑,因應需要而加熱,即可得到網眼構造。The mesh structure of the synthetic polymer can be obtained by crosslinking of the synthetic polymer before crosslinking. That is, a cross-linking agent is added to the synthetic polymer before cross-linking, and if necessary, it is heated to obtain a mesh structure.
交聯劑之例可列舉如:氫氧化鋁、鉀明礬、硫酸鋁、甘胺酸鋁、醋酸鋁、氧化鋁、偏矽酸鋁、氯化鎂、氫氧化鈣、碳酸鈣、偏矽酸鎂鋁、聚乙烯亞胺、聚乙二醇二縮水甘油醚、甘油三縮水甘油醚、異氰尿酸三縮水甘油酯等。Examples of the crosslinking agent include aluminum hydroxide, potassium alum, aluminum sulfate, aluminum glycinate, aluminum acetate, aluminum oxide, aluminum metasilicate, magnesium chloride, calcium hydroxide, calcium carbonate, magnesium aluminum metasilicate, Polyethyleneimine, polyethylene glycol diglycidyl ether, glycerol triglycidyl ether, triglycidyl isocyanurate, and the like.
較佳含量係在化粧品貼敷用凝膠片100重量份中含有0.1至5重量份。The content is preferably 0.1 to 5 parts by weight based on 100 parts by weight of the gel sheet for cosmetic application.
(pH調整劑)(pH adjuster)
調整成交聯劑作用的最適pH,在更確實地交聯之目的下,除了酒石酸、乳酸、乙醇酸等之α-羥基酸之外,亦可將檸檬酸等各種有機酸或鹽酸等無機酸作為pH調整劑(酸觸媒)使用。In addition to the α-hydroxy acid such as tartaric acid, lactic acid or glycolic acid, various organic acids such as citric acid or inorganic acids such as hydrochloric acid may be used as the optimum pH for the action of the crosslinking agent. Use of pH adjuster (acid catalyst).
較佳含量係在化粧品貼敷用凝膠片100重量份中含有0.1至10重量份者。The content is preferably 0.1 to 10 parts by weight based on 100 parts by weight of the gel sheet for cosmetic application.
本發明之化粧品貼敷用凝膠片雖亦能以色素等著色,惟以具有透明至幾乎透明之外觀者為佳。本發明之所謂透明係將凝膠片置載於以黑色印有20點文字之白色優質紙上時,以確保可判讀有無文字之程度的透明性者為佳。本發明之化粧品貼敷用凝膠片中,在無損及凝膠片之透明性,並提高凝膠片之撕裂強度與操作性之目的下,以凝膠片內部在厚度方向含有開口率充分大之織布或不織布者為佳。同時,本發明中,開口率大之織布或不織布係指即使透過織布或不織布仍可判護具有20點排版之程度的大開口率(維持著透明性)者。The gel sheet for cosmetic application of the present invention can also be colored by a pigment or the like, but it is preferably one having a transparent to almost transparent appearance. In the so-called transparent system of the present invention, when the gel sheet is placed on a white high-quality paper printed with black dots of 20 characters, it is preferable to ensure transparency with respect to the presence or absence of characters. In the gel sheet for cosmetic application of the present invention, the inside of the gel sheet contains a sufficient aperture ratio in the thickness direction without impairing the transparency of the gel sheet and improving the tear strength and handleability of the gel sheet. Large weaving or non-woven fabrics are preferred. Meanwhile, in the present invention, the woven fabric or the non-woven fabric having a large opening ratio means that a large aperture ratio (maintaining transparency) having a degree of 20-point layout can be judged even if it is passed through a woven fabric or a non-woven fabric.
本發明之具有透明至幾乎透明外觀的化粧品貼敷用凝膠片,係通過經貼附之凝膠片除了可見到皮膚之改善效果以外,同時具有可正確地貼在所要部位之優異外觀的效果。The gel sheet for cosmetic application having a transparent to almost transparent appearance of the present invention has an effect of improving the excellent appearance of the desired portion in addition to the improvement effect of the skin by the attached gel sheet. .
本發明之化粧品貼敷用凝膠片的厚度,即使整體均一,然部分厚度亦可不同,惟為了確保密著性、透明性與強度,以0.1至3mm之厚度為佳。如未滿0.1mm,則凝膠片之強度較弱,或超出3mm時,因凝膠片本身的重量過重而有密著性不足的情形。另外,凝膠片整體之厚度不足時,可將凝膠片一部分加厚至6mm之厚度。The thickness of the gel sheet for cosmetic application of the present invention may be different depending on the thickness of the gel sheet for the cosmetic application, and it is preferably 0.1 to 3 mm in thickness in order to secure adhesion, transparency and strength. If it is less than 0.1 mm, the strength of the gel sheet is weak, or when it exceeds 3 mm, the gel sheet itself is too heavy and there is insufficient adhesion. Further, when the thickness of the entire gel sheet is insufficient, a part of the gel sheet may be thickened to a thickness of 6 mm.
(羥丙基瓜爾膠)(hydroxypropyl guar)
本發明中所使用之羥丙基瓜爾膠係以豆科植物的瓜爾豆種子之胚乳部分所含的天然水溶性高分子多醣類之瓜爾膠為藉由與氫氧化鈉以及環氧丙烷反應等之方法,使羥基取代為羥丙基而得之非離子性聚合物。The hydroxypropyl guar used in the present invention is a natural water-soluble polymer polysaccharide guar contained in the endosperm portion of the guar seed of legumes by using sodium hydroxide and epoxy A method of propane reaction or the like, which is obtained by substituting a hydroxyl group with a hydroxypropyl group.
為改善由凝膠片滲出之水溶液的垂流性等,雖認為藉由添加作為水溶性增黏劑使用之其他纖維素醚類或纖維素、瓜爾膠、陽離子化瓜爾膠、澱粉、黃原膠(xanthan gum)等多醣類及其衍生物等即可提升水凝膠中之水等的黏度即可解決,惟凝膠本身的保水性上升而會有來自凝膠之含藥液成分等的溶液滲出受到抑制之問題發生,另一方面,滲出溶液之黏度不上升而為原乾澀觸感,對上述之改善效果不足。In order to improve the sagability of the aqueous solution exuded from the gel sheet, it is considered that by adding other cellulose ethers or cellulose, guar gum, cationized guar gum, starch, yellow, which are used as water-soluble tackifiers. Polysaccharides such as xanthan gum and their derivatives can be solved by increasing the viscosity of water in the hydrogel, but the water retention of the gel itself increases and there is a chemical solution derived from the gel. The problem that the solution bleed out is suppressed is caused. On the other hand, the viscosity of the bleed solution does not rise and the texture is the original dry sensation, and the above-mentioned improvement effect is insufficient.
羥丙基瓜爾膠中之羥丙基的取代度以0.4至1.2者為佳。更佳為0.6至1.0者的效果更高。The degree of substitution of the hydroxypropyl group in the hydroxypropyl guar is preferably from 0.4 to 1.2. More preferably, the effect of 0.6 to 1.0 is higher.
羥丙基瓜爾膠係在化粧品貼敷用凝膠片100重量份中含有0.05至3重量份。羥丙基瓜爾膠在化粧品貼敷用凝膠片100重量份中未達0.05重量份時,相較於不含羥丙基瓜爾膠者,未改善垂流性,且在使用中之密著感降低,使用後所感受到的保溼感亦降低。羥丙基瓜爾膠之含量在化粧品貼敷用凝膠片100重量份中超出3重量份時,由於出現強烈的粘膩感,因而使用時之使用感惡化而不佳。較佳之羥丙基瓜爾膠在化粧品貼敷用凝膠片100重量份中含有0.1至2重量份,其中以0.2至1重量份最為適當。The hydroxypropyl guar gum is contained in an amount of 0.05 to 3 parts by weight based on 100 parts by weight of the gel sheet for cosmetic application. When the hydroxypropyl guar is less than 0.05 part by weight in 100 parts by weight of the gel sheet for cosmetic application, it does not improve the sagability and is dense in use as compared with the case without hydroxypropyl guar. The sense of care is reduced, and the moisturizing feeling felt after use is also lowered. When the content of the hydroxypropyl guar is more than 3 parts by weight in 100 parts by weight of the gel sheet for cosmetic application, the feeling of use at the time of use is deteriorated because of the strong sticky feeling. The hydroxypropyl guar gum is preferably contained in an amount of 0.1 to 2 parts by weight, preferably 0.2 to 1 part by weight, per 100 parts by weight of the gel sheet for cosmetic application.
(滲出劑)(exuding agent)
滲出劑係為了使水凝膠內之溶液有效地滲出水凝膠表面而使用之劑材。亦稱為溶液滲出促進劑。例如經由調配一種既為親水性而又具有某種程度之疏水性的物質,即可使水凝膠內部之水有效地吐出。The exuding agent is a agent used to effectively ooze the solution in the hydrogel out of the surface of the hydrogel. Also known as solution oozing accelerator. The water inside the hydrogel can be effectively spit out, for example, by formulating a substance which is both hydrophilic and somewhat hydrophobic.
本發明中之非離子性水溶性高分子係使用聚氧伸乙基甲基葡萄糖苷。The nonionic water-soluble polymer in the present invention is a polyoxyethylidene methyl glucoside.
聚氧伸乙基甲基葡萄糖苷係在化粧品貼敷用凝膠片100重量份中宜含有3至12重量份。聚氧伸乙基甲基葡萄糖苷在化粧品貼敷用凝膠片100重量份中未達3重量份時,因密著感、效果感不足而不佳。聚氧伸乙基甲基葡萄糖苷在化粧品貼敷用凝膠片100重量份中係超出12重量份時,因滲出量過多使垂流性差而不佳。更佳範圍為6至10重量份。The polyoxyethylidene ethyl glucoside is preferably contained in an amount of from 3 to 12 parts by weight per 100 parts by weight of the gel sheet for cosmetic application. When the polyoxyethylidene ethyl glucoside is less than 3 parts by weight in 100 parts by weight of the gel sheet for cosmetic application, the feeling of adhesion and the feeling of effect are insufficient. When the polyoxyethylidene ethyl glucoside exceeds 12 parts by weight in 100 parts by weight of the gel sheet for cosmetic application, the amount of bleeding is too large, and the drooping property is poor. A more preferred range is 6 to 10 parts by weight.
聚氧伸乙基甲基葡萄糖苷在以甘油之吸溼度為100時,係吸溼率70之非離子性水溶性高分子。吸溼率大之非離子性水溶性高分子所具有之保水力雖大,惟具有使水凝膠內之溶液滲出水凝膠表面之能力,而更提高滲出溶液之濕潤感以及保溼效果。Polyoxyethylene methyl glucoside is a nonionic water-soluble polymer having a moisture absorption rate of 70 when the moisture absorption of glycerin is 100. The nonionic water-soluble polymer having a large moisture absorption rate has a large water retention capacity, but has the ability to cause the solution in the hydrogel to exude on the surface of the hydrogel, and further enhances the moisturizing feeling and the moisturizing effect of the oozing solution.
(濕潤劑)(humectant)
濕潤劑之例可列舉如:乙二醇、二乙二醇、三乙二醇、丙二醇、二丙二醇、甘油、二甘油、異丙二醇、1,3-丁二醇、山梨糖醇、麥芽糖醇(maltitol)、海藻糖、棉子糖、木糖醇、甘露醇、玻尿酸及其鹽、海藻糖及棉子糖等之各種衍生物、三甲基甘胺酸、環糊精、玻尿酸及其鹽等二醇類、多元醇類及多糖類等。該等可單獨或混合2種以上使用。Examples of the humectant include ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, glycerin, diglycerin, isopropyl glycol, 1,3-butylene glycol, sorbitol, and maltitol ( Maltitol), trehalose, raffinose, xylitol, mannitol, hyaluronic acid and its salts, various derivatives of trehalose and raffinose, trimethylglycine, cyclodextrin, hyaluronic acid and its salts, etc. Glycols, polyols and polysaccharides. These may be used alone or in combination of two or more.
該等濕潤劑之較佳含量係在化粧品貼敷用凝膠片100重量份中含有1至30重量份。The preferred content of the humectant is 1 to 30 parts by weight based on 100 parts by weight of the gel sheet for cosmetic application.
(藥效成分)(medicinal ingredients)
本發明中可調配之藥效成分只要為以往醫藥品、藥粧品(quasi drug)、化粧品、衛生材料、雜貨等所使用者即可,而無特別限定,其例可列舉如:明日葉萃取物、酪梨萃取物、甘茶萃取物、藥蜀葵萃取物、山金車萃取物、山杏萃取物、杏核萃取物、小茴香萃取物、薑黃萃取物、烏龍茶萃取物、紫錐菊葉萃取物、黃芩萃取物、黃柏萃取物、大麥萃取物、荷蘭芥末萃取物、柑橘萃取物、海水乾燥物、水解彈性蛋白、水解小麥粉末萃取物、水解乳萃取物、洋甘菊萃取物、胡蘿蔔萃取物、茵蔯蒿萃取物、甘草萃取物、洛神花萃取物、奇異果萃取物、奎寧萃取物、小黃爪萃取物、鳥嘌呤核苷、山白竹萃取物、核桃萃取物、葡萄柚萃取物、鐵線蓮萃取物、酵母萃取物、牛蒡萃取物、紫草萃取物、膠原蛋白、蔓越莓萃取物、柴胡萃取物、臍帶萃取液、一串紅萃取物、肥皂草萃取物、竹萃取物、野山楂(Crataegus cuneata)萃取物、香菇萃取物、地黃萃取物、紫根萃取物、華東椴萃取物、繡線菊萃取物、菖蒲根萃取物、白樺萃取物、木賊萃取物、金銀花萃取物、常春藤萃取物、歐山楂(Crataegus oxyacantha)萃取物、黑接骨木(Blcak elder)萃取物、洋蓍草萃取物、歐薄荷萃取物、錦葵萃取物、大棗萃取物、百里香萃取物、丁香萃取物、白茅萃取物、陳皮萃取物、苦橙皮萃取物、魚腥草萃取物、蕃茄萃取物、納豆萃取物、人蔘萃取物、野玫瑰萃取物、木槿花萃取物、麥門冬萃取物、香芹萃取物、蜂蜜、藥用牆草萃取物、藍萼香茶菜萃取物、沒藥醇萃取物、款冬蒲公英萃取物、蜂斗菜萃取物、伏苓萃取物、假葉樹萃取物、葡萄萃取物、蜂膠萃取物、絲瓜萃取物、薄荷萃取物、椴樹萃取物、啤酒花萃取物、松樹皮萃取物、七葉樹萃取物、水芭蕉萃取物、無患子萃取物、蜜桃萃取物、矢車菊萃取物、尤加利樹萃取物、香橙萃取物、艾草萃取物、薰衣草萃取物、蘋果萃取物、萵苣萃取物、檸檬萃取物、紫雲英萃取物、玫瑰花萃取物、迷迭香萃取物、羅馬洋甘菊萃取物、蜂王漿萃取物等。The medicinal ingredient which can be blended in the present invention is not particularly limited as long as it is a user of a conventional pharmaceutical, a quasi drug, a cosmetic, a sanitary material, or a miscellaneous product, and examples thereof include: tomorrow leaf extract , Avocado Extract, Sweet Tea Extract, Herbal Hollyhock Extract, Arnica Extract, Apricot Extract, Apricot Kernel Extract, Cumin Extract, Turmeric Extract, Oolong Tea Extract, Echinacea Extract, Astragalus Extract, Cortex Extract, Barley Extract, Dutch Mustard Extract, Citrus Extract, Seawater Drying, Hydrolyzed Elastin, Hydrolyzed Wheat Powder Extract, Hydrolyzed Milk Extract, Chamomile Extract, Carrot Extract, Artemisia selengensis Extract, Licorice Extract, Rose Flower Extract, Kiwi Fruit Extract, Quinine Extract, Small Yellow Paw Extract, Guanosine, Mountain White Bamboo Extract, Walnut Extract, Grapefruit Extract, Clematis Extract, yeast extract, burdock extract, comfrey extract, collagen, cranberry extract, Bupleurum extract, umbilical cord extract, a string of red extracts, Soap extract, bamboo extract, Crataegus cuneata extract, shiitake mushroom extract, Rehmannia extract, purple root extract, East China glutinous extract, Spiraea extract, Caladium root extract, Birch extract , Equisetum extract, Honeysuckle extract, Ivy extract, Crataegus oxyacantha extract, Black elm (Blcak elder) extract, Jerusalem artichoke extract, Peppermint extract, Mallow extract, Jujube extract, thyme extract, clove extract, whitegrass extract, dried tangerine peel extract, bitter orange peel extract, Houttuynia cordata extract, tomato extract, natto extract, mantis extract, wild rose extract , hibiscus extract, wheat winter extract, parsley extract, honey, medicinal wall extract, blue musk tea extract, bisabol extract, coltsfoot dandelion extract, butterbur extract , Fuxi Extract, False Leaf Extract, Grape Extract, Propolis Extract, Loofah Extract, Peppermint Extract, Eucalyptus Extract, Hop Extract, Pine Bark Extract, Buckeye Extract Water Plantain Extract, Sapindus Extract, Peach Extract, Bluebonnet Extract, Eucalyptus Tree Extract, Orange Extract, Wormwood Extract, Lavender Extract, Apple Extract, Lettuce Extract, Lemon Extract, Milk vetch extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, etc.
亦可列舉如:去氧核糖核酸、硫酸軟骨素鈉、膠原蛋白、彈力蛋白、幾丁質、幾丁聚糖(chitosan)、水解卵殼膜等之生物高分子;胺基酸、尿素、吡咯啶酮羧酸鈉、甜菜鹼、乳清、三甲基甘胺酸等保溼成分;神經鞘脂質、神經醯胺、膽固醇、膽固醇衍生物、磷脂質等油性成分;ε-胺基己酸、甘草酸、β-甘草次酸、氯化溶菌酶、愈創藍油烴、皮質醇等抗發炎劑;維他命A、維他命B、維他命B6、維他命D、維他命E、泛酸鈣、生物素、菸鹼醯胺等維他命類;尿囊素、二氯乙酸二異丙胺、4-胺基甲基環己烷羧酸等活性成分;生育酚、類胡蘿蔔素、類黃酮、單寧、木酚素(lignan)、皂素等抗氧化劑;γ-米糠醇、維他命E衍生物等血液循環促進劑;視網醇、視網醇衍生物等傷口癒合劑;頭花千金藤素、辣椒酊、檜木醇、含碘大蒜精、鹽酸吡哆醇、d1-α-生育酚、d1-α生育酚醋酸酯、菸鹼酸、菸鹼酸衍生物、泛酸鈣、D-泛醇、乙醯泛醇基乙基醚、生物素、尿囊素、異丙基甲基酚、雌二醇、乙炔基雌二醇、卡普氯銨(Carpronium Chloride)、氯化苯二甲烴銨(benzalkonium chloride)、鹽酸苯海拉明(Diphenhydramine Hydrochloride)、感光素(Takanal)、樟腦、水楊酸、壬酸香草醯胺、吡羅克酮乙醇胺鹽、十五烷酸甘油酯、單硝基愈創木酚、間苯二酚、γ-胺基丁酸、氯化苯銨松寧(benzethonium chloride)、鹽酸美西律(Mexiletine Hydrochloride)、茁長素(auxin)、女性荷爾蒙、斑蟊酊(Cantharides tincture)、環孢靈(Cyclosporin)、氫化可體松(hydrocotisone)、聚氧伸乙基山梨醇酐單硬脂酸酯、止痛劑、精神安定劑、降血壓劑、抗生素、抗組織胺劑、抗菌性物質等。Also mentioned are: biopolymers such as deoxyribonucleic acid, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membrane, etc.; amino acid, urea, pyrrole Moisturizing ingredients such as sodium ketone ketone, betaine, whey, trimethylglycine; oily components such as sphingolipid, neuropterin, cholesterol, cholesterol derivatives, phospholipids; ε-aminohexanoic acid, Anti-inflammatory agents such as glycyrrhizic acid, β-glycyrrhetinic acid, chlorinated lysozyme, guaiac blue oil hydrocarbon, cortisol; vitamin A, vitamin B, vitamin B6, vitamin D, vitamin E, calcium pantothenate, biotin, nicotine Vitamins such as guanamine; active ingredients such as allantoin, diisopropylamine dichloroacetate, 4-aminomethylcyclohexanecarboxylic acid; tocopherol, carotenoids, flavonoids, tannins, lignans ), saponin and other antioxidants; γ-methanol, vitamin E derivatives and other blood circulation promoters; retinol, retinol derivatives and other wound healing agents; head flower ginseng, capsicum, eucalyptus, containing Iodine garlic essence, pyridoxine hydrochloride, d1-α-tocopherol, d1-α tocopherol Acid ester, nicotinic acid, nicotinic acid derivative, calcium pantothenate, D-panthenol, ethyl ethionyl ethyl ether, biotin, allantoin, isopropyl methyl phenol, estradiol, ethynyl Estradiol, Carpronium Chloride, benzalkonium chloride, Diphenhydramine Hydrochloride, Takanal, camphor, salicylic acid, citric acid vanilla Indamine, piroctone, ethanolamine salt, pentadecanoic acid glyceride, mononitroguaiacol, resorcinol, γ-aminobutyric acid, benzethonium chloride, hydrochloric acid Mexiletine Hydrochloride, auxin, female hormone, Cantharides tincture, Cyclosporin, hydrocotisone, polyoxyethyl ether sorbitan A fatty acid ester, an analgesic, a neuroleptic, a blood pressure lowering agent, an antibiotic, an antihistamine, an antibacterial substance, and the like.
該等成分之調配量因其材料而有效成分量不同而無法統一規定,惟一般相對於化粧品貼敷用凝膠片之質量,係以0.05至30質量%者為佳。The blending amount of the components may not be uniformly defined depending on the amount of the active ingredient of the material, but it is generally preferably 0.05 to 30% by mass based on the mass of the gel sheet for cosmetic application.
(製造方法)(Production method)
例如可採用之方法係在至少將合成高分子、羥丙基瓜爾膠、濕潤劑以及水混合而得的混合物中,再添加交聯劑與作為滲出劑之聚氧伸乙基甲基葡萄糖苷加以混合並使之反應者。可採用之較佳的製造方法,其特徵係:添加pH調整劑(酸觸媒)使混合溶液之pH值調整為4至7並使之反應者。For example, a method may be employed in which at least a mixture of a synthetic polymer, a hydroxypropyl guar, a wetting agent, and water is mixed, and a crosslinking agent and a polyoxyethylidene methyl glucoside as an exuding agent are further added. Mix and react to the person. A preferred manufacturing method can be employed, characterized in that a pH adjusting agent (acid catalyst) is added to adjust the pH of the mixed solution to 4 to 7 and react it.
其中最重要者係將羥丙基瓜爾膠預先添加在合成高分子與濕潤劑中使羥丙基瓜爾膠溶解後,再添加交聯劑與作為滲出劑之聚氧伸乙基甲基葡萄糖苷之點。換言之,由於聚氧伸乙基甲基葡萄糖苷在室溫中為液體而無問題,惟期望羥丙基瓜爾膠係在形成凝膠之前添加。如羥丙基瓜爾膠係在形成凝膠之後添加,則步驟增多而使成本增高,亦無法形成均質的貼敷片。亦即,如羥丙基瓜爾膠係在形成凝膠後而添加時,固體的羥丙基瓜爾膠難以均質地分散在凝膠表面,例如:由於作成水溶液添加時亦為高黏度,因而難以均質地分散。另外,為了形成低黏度而作成低濃度之水溶液添加時,亦由於過剩之水而無法獲得所需求的特性(使用性、效果感)。並且,無法均質地分散時,滲出液之黏度不均,例如有部分易於剝離或保溼效果僅為局部性等而無法獲得所需求之特性,因而不佳。The most important one is to pre-add hydroxypropyl guar to the synthetic polymer and humectant to dissolve the hydroxypropyl guar, then add the cross-linking agent and polyoxyethyl ketone as the exuding agent. The point of glycosides. In other words, since the polyoxyethylidene ethyl glucoside is liquid at room temperature without problems, it is desirable that the hydroxypropyl guar gum is added before the gel is formed. If the hydroxypropyl guar gum is added after the gel is formed, the number of steps is increased to increase the cost, and a homogeneous patch cannot be formed. That is, if the hydroxypropyl guar gum is added after forming a gel, the solid hydroxypropyl guar is difficult to uniformly disperse on the surface of the gel, for example, because it is also added as a high viscosity in aqueous solution, It is difficult to disperse homogeneously. Further, in order to form a low-concentration aqueous solution in order to form a low viscosity, the required characteristics (usability, effect feeling) cannot be obtained due to excess water. Further, when it is not uniformly dispersed, the viscosity of the exudate is not uniform, and for example, some of them are easily peeled off or the moisturizing effect is only local, and the desired characteristics are not obtained, which is not preferable.
化粧品貼敷用凝膠片之製造方法,係例如在至少將合成高分子0.5至35重量份(以1至30重量份為佳,2至25重量份更佳)與羥丙基瓜爾膠0.05至3重量份(以0.1至2重量份為佳,0.2至1重量份更佳)與濕潤劑1至30重量份(以2至20重量份為佳)以及水混合而得的混合物中,再添加交聯劑0.1至5重量份(以0.5至2重量份為佳)與作為滲出劑的聚氧伸乙基甲基葡萄糖苷3至12重量份(以6至12重量份為佳)並混合使之反應者。The method for producing a gel sheet for cosmetic application is, for example, at least 0.5 to 35 parts by weight of the synthetic polymer (preferably 1 to 30 parts by weight, more preferably 2 to 25 parts by weight) and hydroxypropyl guar 0.05. To 3 parts by weight (preferably 0.1 to 2 parts by weight, more preferably 0.2 to 1 part by weight) and 1 to 30 parts by weight (preferably 2 to 20 parts by weight) of the wetting agent, and a mixture of water, and then Adding 0.1 to 5 parts by weight of the crosslinking agent (preferably 0.5 to 2 parts by weight) and 3 to 12 parts by weight (preferably 6 to 12 parts by weight) of the polyoxyethylidene glucoside as an exuding agent and mixing Make it a reaction.
其中,化粧品貼敷用凝膠片之製造方法,更佳者係添加pH調整劑(酸觸媒)0.1至10重量份(以1至5重量份為佳)使混合溶液之pH值調整為4至7並使之反應者。In the method for producing a gel sheet for cosmetic application, it is more preferred to add a pH adjuster (acid catalyst) to 0.1 to 10 parts by weight (preferably 1 to 5 parts by weight) to adjust the pH of the mixed solution to 4 To 7 and make it a reaction.
另外,水之總量以添加60至97重量份為佳,以70至95重量份更佳。較佳者係先將上述水之一部分添加於交聯劑與滲出劑之混合物中再作為混合溶液而添加。Further, the total amount of water is preferably 60 to 97 parts by weight, more preferably 70 to 95 parts by weight. Preferably, one part of the above water is added to the mixture of the crosslinking agent and the exuding agent and then added as a mixed solution.
[實施例][Examples]
以下,依實施例與比較例說明本發明,然而本發明並不僅限於此。Hereinafter, the invention will be described by way of examples and comparative examples, but the invention is not limited thereto.
(實施例)(Example)
使用下表所示之凝膠形成用組成物,並依以下順序作成化粧品貼敷片中所用之各實施例‧比較例的凝膠片。在合成高分子與羥丙基瓜爾膠(HP瓜爾膠)或其他增黏劑中添加濕潤劑,再添加藥效成分以及水並充分攪拌混合至均勻為止。The gel-forming composition shown in the following table was used, and the gel pieces of each of the examples and the comparative examples used in the cosmetic patch were prepared in the following order. Add a wetting agent to the synthetic polymer and hydroxypropyl guar (HP guar) or other tackifier, add the medicinal ingredient and water, and mix well until it is homogeneous.
在該混合物中添加作為滲出劑之聚氧伸乙基甲基葡萄糖苷,再添加交聯劑與水使充分分散而作成淤漿,並在該淤漿中添加pH調整劑(酸觸媒),合計作為100份,充分地混合攪拌。其次,在平滑玻璃板上所置載38μm厚度的PET膜(聚對苯二甲酸乙二酯)之四邊放置1mm厚度的間隔板,將適量之上述組成物混合結束後使即刻流入其中央部分,疊上單位面積重量17g/m2 之尼龍針織布(半針織)與另一片38μm厚度的PET膜,再自其上以玻璃板夾住放置24小時,得到厚度1mm之凝膠片。將該凝膠片裁成5cm×5cm作為評估用試料。Adding polyoxyethylidene methyl glucoside as an exuding agent to the mixture, adding a crosslinking agent and water to sufficiently disperse and slurrying, and adding a pH adjuster (acid catalyst) to the slurry. In total, as 100 parts, the mixture was thoroughly mixed and stirred. Next, a spacer having a thickness of 1 mm was placed on four sides of a PET film (polyethylene terephthalate) having a thickness of 38 μm placed on a smooth glass plate, and an appropriate amount of the above composition was mixed to immediately flow into the central portion thereof. A nylon knitted fabric (half knitting) having a basis weight of 17 g/m 2 and another PET film having a thickness of 38 μm were stacked, and then placed thereon with a glass plate for 24 hours to obtain a gel sheet having a thickness of 1 mm. The gel piece was cut into 5 cm × 5 cm as a sample for evaluation.
[表1][Table 1]
由凝膠片所滲出液體的滲出量係如下測定。The amount of exudation of the liquid exuded from the gel sheet was measured as follows.
凝膠片係在測定前一刻由袋中取出並剝下雙面之PET膜,測定重量(a)後,僅在單面貼附PET膜。預備2片玻璃板(100×100mm厚度3mm)與濾紙(Advantec公司製造之5A直徑150mm圓形),測定濾紙重量(b)並置於1片玻璃板上。在濾紙之中央部使凝膠面朝下貼上凝膠片,於其上亦置載1片玻璃板並靜置10分鐘。然後,拿掉玻璃板與凝膠片上之PET膜,再去除凝膠並僅測定圓形濾紙之重量(c),從與預先測定之濾紙重量的差算出滲出液之重量。將該液量作為以相對於原有凝膠重量之比例表示之滲出量((c-b)/a)。測定值係使用3片凝膠進行相同試驗之結果的平均值。由於滲出量過少時降低對肌膚的密著性,在使用中易於剝落,且對皮膚的滲透量亦少,因此保溼感等效果不足,過大時則因凝膠之重量而發生偏移掉落,且過剩液體垂流(垂液)而附著於衣物等,因此滲出量之較佳範圍為20至35(%)。The gel sheet was taken out from the bag immediately before the measurement and the double-sided PET film was peeled off, and after measuring the weight (a), the PET film was attached only to one side. Two glass plates (100 × 100 mm thickness: 3 mm) and filter paper (5 A diameter 150 mm round manufactured by Advantec Co., Ltd.) were prepared, and the weight (b) of the filter paper was measured and placed on a glass plate. A gel sheet was attached to the center of the filter paper with the gel facing down, and one glass plate was placed thereon and allowed to stand for 10 minutes. Then, the glass film and the PET film on the gel sheet were removed, the gel was removed, and only the weight (c) of the circular filter paper was measured, and the weight of the exudate was calculated from the difference from the weight of the previously determined filter paper. The amount of the liquid was taken as the amount of exudation ((c-b)/a) expressed as a ratio with respect to the weight of the original gel. The measured value is the average of the results of the same test using 3 gels. When the amount of exudation is too small, the adhesion to the skin is lowered, and it is easy to peel off during use, and the amount of penetration into the skin is small. Therefore, the effect of moisturizing and the like is insufficient, and when it is too large, the weight of the gel is shifted and dropped. Further, the excess liquid is dripped (dip liquid) and adhered to the clothes or the like, so that the amount of bleeding is preferably in the range of 20 to 35 (%).
作為[貼敷劑之評估]As an evaluation of the patch
將上述所形成之凝膠片貼附在上半身坐直狀態之10名女性受驗者之臉頰,將靜置20分鐘時之密著性以及垂流性之評估,與20分鐘後剝離後之肌膚狀態之保溼感以下述1至5之5階段表現,評估作為貼敷劑之使用性及效果感,並將所有受驗者之合計點數作為評估結果。因此,該等評估值係表示性能與效果之大小(滿分50點)。將其結果呈示於表中。The gel pieces formed as described above were attached to the cheeks of 10 female subjects in a state where the upper body was sitting upright, and the adhesion and drooping evaluation were allowed to stand for 20 minutes, and the skin was peeled off after 20 minutes. The moisturizing feeling of the state was expressed in the following five stages of 1 to 5, and the usability and effect feeling of the patch were evaluated, and the total points of all the subjects were used as the evaluation results. Therefore, these evaluation values represent the magnitude of performance and effect (out of 50 points). The results are presented in the table.
效果感(保溼感)評估Effect (moisturizing) assessment
5:感覺到肌膚有明顯的保溼。5: I feel that the skin has obvious moisturizing.
4:感覺到肌膚有保溼。4: I feel the skin is moisturized.
3:感覺到肌膚有些保溼。3: I feel a little moisturizing.
2:感覺到肌膚僅有些微保溼。2: I feel that the skin is only slightly moisturized.
1:感覺不到效果。1: I can't feel the effect.
使用性(垂流性)評估Usability (dragging) assessment
5:毫無垂流性。5: No drooping.
4:僅有些微垂流性。4: Only slightly sag.
3:有些垂流性。3: Some drooling.
2:垂流性多。2: More drooling.
1:垂流性過多,所滲出之液甚至沾附到衣物的程度。1: Excessive drooling, the degree of oozing liquid even adheres to clothing.
使用性(密著性)評估Usability (adhesion) assessment
5:完全與肌膚密著而無偏移。5: Completely adhered to the skin without offset.
4:幾乎與肌膚密著,僅有些許偏移。4: Almost the skin is tight, only a little offset.
3:存在著不與肌膚密著之部分而有些偏移。3: There is some offset from the skin that is not intimate with the skin.
2:難與肌膚密著,偏移多。2: It is difficult to keep close to the skin and has a lot of deviation.
1:偏移過大而掉落。1: The offset is too large and falls.
由表1可知,不論藥效成分為水性或油性,實施例1至6之凝膠片,相較於無添加聚氧伸乙基甲基葡萄糖苷之比較例1,係滲出量適度且使用性(垂流性、密著性)、效果感(保溼感)優異者。相對於化粧品貼敷用凝膠片100重量份,聚氧伸乙基甲基葡萄糖苷為15重量份的比較例2,由於聚氧伸乙基甲基葡萄糖苷過多而使滲出量過剩,因此在垂流性、密著性方面不足。As can be seen from Table 1, the gel tablets of Examples 1 to 6 were compared with Comparative Example 1 without the addition of polyoxyethylidene ethylglycoside, regardless of whether the medicinal component was aqueous or oily, and the amount of exudation was moderate and usable. (drip, adhesion), effect (moisturizing) is excellent. In Comparative Example 2 in which the polyoxyethylidene ethyl glucoside was 15 parts by weight with respect to 100 parts by weight of the gel sheet for cosmetic application, the amount of exudation was excessive due to excessive polyoxyethylidene methyl glucoside, and thus Insufficient sag and adhesion.
以作為其他增黏劑之瓜爾膠、陽離子化瓜爾膠、黃原膠、羥乙基纖維素取代羥丙基瓜爾膠之比較例3至6,滲出量雖適度,但垂流性、密著性不足,且保溼感不足。並且,以玻尿酸鈉作為其他增黏劑之比較例7,垂流性雖佳,但滲出量不足,密著性降低且保溼感不足。Comparative Examples 3 to 6 in which guar gum, cationized guar gum, xanthan gum, and hydroxyethyl cellulose were substituted as hydroxypropyl guar as other tackifiers, although the amount of exudation was moderate, but the sag, Insufficient adhesion and insufficient moisturizing feeling. Further, in Comparative Example 7 in which sodium hyaluronate was used as another tackifier, the drooping property was good, but the amount of bleeding was insufficient, the adhesion was lowered, and the moisturizing feeling was insufficient.
相對於化粧品貼敷用凝膠片100重量份,HP瓜爾膠超出3重量份的比較例8,呈現強烈的黏著感,使用時之使用感惡化。相對於化粧品貼敷用凝膠片100重量份,HP瓜爾膠未達0.05重量份的比較例9,由於HP瓜爾膠過少,滲出量雖適度,但垂流性、密著性不充分使得效果感不足。In comparison with Comparative Example 8 in which the HP guar gum exceeded 3 parts by weight, 100 parts by weight of the gel sheet for cosmetic application showed a strong adhesive feeling, and the feeling of use at the time of use deteriorated. Compared with 100 parts by weight of the gel sheet for cosmetic application, the HP guar was less than 0.05 part by weight of Comparative Example 9. Since the amount of HP guar was too small, the amount of bleeding was moderate, but the drooping property and the adhesion were insufficient. Insufficient effect.
本發明可使用作為貼附在顏面、腕臂、足部等之化粧品貼敷用凝膠片,可用於作用使用水凝膠外用劑之護膚用凝膠貼敷片。The present invention can be used as a gel sheet for cosmetic application applied to a face, a wrist, a foot, or the like, and can be used as a skin care gel patch for using a hydrogel external preparation.
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JP2009073260A JP5503888B2 (en) | 2009-03-25 | 2009-03-25 | Gel sheet for cosmetic pack |
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KR101755306B1 (en) * | 2010-11-30 | 2017-07-11 | (주)아모레퍼시픽 | Cosmetic composition for mask pack |
KR20140068849A (en) * | 2011-06-14 | 2014-06-09 | 가부시키가이샤 시세이도 | Thin film supporting hyaluronic acid or derivative thereof and thin film cosmetic |
ITBS20110100A1 (en) * | 2011-07-13 | 2013-01-14 | Nale | INTIMATE GARMENT FOR THE TREATMENT OF SKIN INESTETISMS |
WO2013108918A1 (en) * | 2012-01-20 | 2013-07-25 | 積水化成品工業株式会社 | Pack cosmetic accommodating article, cosmetic pack, and manufacturing method for pack cosmetic |
KR20130133970A (en) * | 2012-05-30 | 2013-12-10 | 주식회사 센바이텍 | Mask for low frequency device and optical cure apparatus |
JP6265497B2 (en) * | 2012-09-18 | 2018-01-24 | 日産化学工業株式会社 | Hydrogel-forming composition and hydrogel made therefrom |
JP6265498B2 (en) * | 2012-09-18 | 2018-01-24 | 日産化学工業株式会社 | Hydrogel-forming composition and hydrogel made therefrom |
WO2014132783A1 (en) * | 2013-02-28 | 2014-09-04 | 株式会社マンダム | Gel composition for skin |
CN103213758B (en) * | 2013-05-13 | 2016-01-20 | 孙秋玉 | Eye adornment pad pasting |
CN103385545A (en) * | 2013-07-29 | 2013-11-13 | 吴江市峰益纺织有限公司 | Gel skin-whitening, moisture-preserving and body-shaping wear |
CN105705584B (en) * | 2013-11-11 | 2020-05-12 | 日产化学工业株式会社 | Hydrogel-forming composition and hydrogel produced therefrom |
JP6193846B2 (en) * | 2013-12-27 | 2017-09-06 | 積水化成品工業株式会社 | pack |
JP6430128B2 (en) * | 2014-02-17 | 2018-11-28 | コスメディ製薬株式会社 | Cosmetic gel sheet and method for producing the same |
JP6204604B2 (en) * | 2014-09-30 | 2017-09-27 | 積水化成品工業株式会社 | Gel sheet for makeup |
WO2016208044A1 (en) * | 2015-06-25 | 2016-12-29 | 積水化成品工業株式会社 | Pack |
CN105544213B (en) * | 2016-01-21 | 2018-05-15 | 苏州印丝特纺织数码科技有限公司 | Polypropylene slurry that a kind of egg shell is modified and preparation method thereof |
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JP7037639B2 (en) * | 2018-03-30 | 2022-03-16 | 積水化成品工業株式会社 | Hydrogel |
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HK1148205A1 (en) | 2011-09-02 |
JP2010222320A (en) | 2010-10-07 |
CN101843567B (en) | 2012-12-12 |
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TW201034693A (en) | 2010-10-01 |
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