CN106063770B - A kind of gel pad pasting containing growth factor and preparation method thereof - Google Patents
A kind of gel pad pasting containing growth factor and preparation method thereof Download PDFInfo
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- CN106063770B CN106063770B CN201610375168.XA CN201610375168A CN106063770B CN 106063770 B CN106063770 B CN 106063770B CN 201610375168 A CN201610375168 A CN 201610375168A CN 106063770 B CN106063770 B CN 106063770B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The invention belongs to cosmetic field, and in particular to a kind of gel pad pasting containing growth factor and preparation method thereof, and the pad pasting is made up of the hydrogel of base material and coating on the substrate, and the hydrogel includes the component of following mass percent：High molecular weight hydrophilic gel-type vehicle, growth factor, NMF, hyaluronic acid, allantoin, transdermal promotion absorbent, crosslinking agent, cross-linked evocating agent, chelating agent, plants essential oil and deionized water, the high molecular weight hydrophilic gel-type vehicle press 1 by sodium carboxymethylcellulose and Sodium Polyacrylate:0.1~5 weight is than composition.The invention provides it is a kind of with good close sense and salubrious sense have simultaneously height whitening, moistening effect gel pad pasting.
Description
Technical field
The invention belongs to cosmetic field, and in particular to a kind of gel pad pasting containing growth factor and preparation method thereof.
Background technology
The hydrophilic hydrogel pad pasting made at present with natural polymer cross-linked polymer, because it has transparency good, entirely
Naturally, it is safe, the aqueous advantage such as abundant and increasingly welcome by consumer.
Hydrogel adhesive film is mainly made up of crosslinking cosmetic material with the water-soluble polymer in hydrogel, skin care activity into
Divide and be stored in hydrogel.Compared with the sheet pad pasting of its non-woven fabric with being soaked with elite, hydrogel adhesive film is almost occurred without
It is sagging, and good use feeling can be provided, but its weak point be close sense when using, use after salubrious sense and moisturizing sense not
Foot；The adhesiveness of another gel pad pasting is not high, easily flows and comes off when using, is difficult painting exhibition.
Chinese patent application discloses Golden flower flower mud pad pasting and preparation method thereof, and each component raw material percentage composition is such as
Under：Golden flower flower 20~30%, sponge gourd flower 20~30%, propane diols 5~8%, carbomer 0.3~0.7%, triethanolamine
1.0~1.5%, EUXYL K300 0.05~0.1%, citral 0.002~0.005%, surplus are that luffa vine grows water.The patch
The preparation method of film comprises the following steps：1) luffa vine grows water sterilization, filters stand-by；2) flower crushing, stirring is treated into muddy
With；3) carbomer is grown water-swellable with luffa vine；4) carbomer gel matrix is prepared；5) citral is dissolved in after propane diols, plus
Enter luffa vine and grow water, obtain solution I；6) solution I and flower slurries are added in gel-type vehicle, add EUXYL K300,
It is uniformly mixed and both obtains Golden flower flower mud pad pasting.The pad pasting has whitening, moisture-keeping efficacy, and has no side effect.Use this
The gel pad pasting that method is prepared has a preferable transparency, but its close sense when using and salubrious sense after using are not
Foot, it is difficult to meet the requirement of consumer.
Therefore, for technical problem present in above-mentioned prior art, need badly and propose that a kind of use feeling is good, tack is strong,
Moistening effect is excellent and the good gel pad pasting of stability.
The content of the invention
For close sense when solving that gel pad pasting is used in the prior art, use after salubrious sense and moisturizing sense it is not enough
Technical problem, it is an object of the invention to provide a kind of gel pad pasting containing growth factor and preparation method thereof, with solve with
Upper defect.
The invention provides a kind of gel pad pasting containing growth factor, the pad pasting is by base material and is coated on the base
Hydrogel composition on material, the hydrogel includes the component of following mass percent：High molecular weight hydrophilic gel-type vehicle 2~8%,
Growth factor 0.005~0.1%, NMF 20~40%, hyaluronic acid 0.005~0.03%, allantoin 0.005~
0.03%th, transdermal promotion absorbent 0.1~0.3%, crosslinking agent 0.2~1%, cross-linked evocating agent 0.2-1%, chelating agent 0.01-
1%th, plants essential oil 0.05~1% and deionized water 50~70%, the high molecular weight hydrophilic gel-type vehicle is by carboxymethyl cellulose
Plain sodium and Sodium Polyacrylate press 1:0.1~5 weight is than composition.
Preferably, the hydrogel includes the component of following mass percent：High molecular weight hydrophilic gel-type vehicle 5%, growth
The factor 0.05%, NMF 27%, hyaluronic acid 0.01%, allantoin 0.01%, transdermal promotion absorbent 0.15%, crosslinking agent
0.5%th, cross-linked evocating agent 0.2%, chelating agent 0.03%, plants essential oil 0.4% and deionized water 60%, the macromolecule parent
Hydrogel matrix presses 1 by Sodium Polyacrylate and sodium carboxymethylcellulose:3 weight is than composition.
Preferably, the base material is selected from non-woven fabrics.
Preferably, the crosslinking agent is selected from calcium sulfate, calcium hydroxide, calcium chloride, aluminium hydroxide, aluminium chloride and dihydroxy aluminium ammonia
The one or more of guanidine-acetic acid salt, the cross-linked evocating agent is selected from one or both of citric acid, tartaric acid and lactic acid.
Preferably, the growth factor is selected from recombinant human epidermal growth factor and/or recombination human basic fibroblast cell is given birth to
The long factor.
Preferably, the NMF is selected from glycerine, and the chelating agent is selected from EDTA-2Na and/or EDTA-4Na.
Preferably, the transdermal one or more for promoting absorbent in Tween-80, azone and hydrolecithin.
Preferably, the transdermal promotion absorbent is selected from Tween-80.
Preferably, the plants essential oil be selected from tea oil, lavender oil, rose oil, walnut oil, cinnamon oil, orange oil,
Apricot kernel oil, coconut oil, Blumea oil, Michelia oil, lily caul-fat, peppermint oil, cloves caul-fat, JIANGGENYOU, jasmin oil, Apple Seeds
The one or more of oil, rose caul-fat, evening primrose oil and lemon peel oil.
Preferably, the hydrogel also includes 0.05~0.1% preservative and 0.005-0.03% essence.
Correspondingly, present invention also offers a kind of preparation method of the above-mentioned gel pad pasting containing growth factor, including with
Lower step：
A) high molecular weight hydrophilic gel-type vehicle is fully soaked with 20~40% NMFs, addition 0.2-1% cross-linked evocating agents,
0.2~1% crosslinking agent, 0.05~1% plants essential oil, 0.1~0.3% transdermal promotion absorbent, stir 15~30min；
B deionized water 50~70% and chelating agent 0.01-1%) are continuously added, is stirred, addition 0.005~
0.1% growth factor, 0.005~0.03% hyaluronic acid, 0.005~0.03% allantoin, are stirred under vacuum 3~10min, are made
The gel-type vehicle of flow-like；
C) gel-type vehicle of above-mentioned flow-like is coated with by hydrogel adhesive film machine, cut, is produced.
Preferably, the step B) in also include adding 0.05~0.1% preservative and 0.005-0.03% essence.
The present invention adds the crosslinking that cross-linked evocating agent triggers it with crosslinking agent anti-using high molecular weight hydrophilic gel-type vehicle as raw material
It should produce, add the speed of chelating agent control reaction, the same of gel stretchability can just not influenceed by forming the viscosity of gel
The close sense of Shi Zengjia gels, while active component can be made to be uniformly dispersed.
The present invention is also added into recombinant human epidermal growth factor and recombination human basic fibroblast growth factor, and it can promote
Enter the regeneration of skin collagen and the restructuring of fibr tissue, strengthen skin elasticity, reduce skin sensitivity, can make facial thick
Greatly, flush, the capillary atrophy of expansion attenuate and shoaled, it is to avoid pigment deposition, dispel facial toxin residual, have light spot dispel print,
Effect of wrinkle resistance, whitening.Other skin conditioning agents, such as allantoin, hyaluronic acid in both collaboration plants essential oils and system
Deng with more excellent skin whitening, moisturizing effect, making dark and gloomy skin reappear the soft and smooth exquisiteness of silkiness, shine moving brilliance.
Compared with prior art, inventive gel pad pasting has the advantage that：
1) present invention compounds sodium carboxymethylcellulose and Sodium Polyacrylate to form gel-type vehicle with certain proportioning, and two
The mutual Synergistic of person, the gel of formation has an excellent transparency, and is added while close sense when keeping using
Salubrious sense after use, it is deep to be welcome by consumer.
2) collective effect of plants essential oil and growth factor so that inventive gel pad pasting has height whitening and moisturizing
Effect, while the good outward appearance having, it is easy to apply exhibition and be absorbed by the skin.
Embodiment：
Below by way of the description of embodiment, the invention will be further described, but this is not the limit to the present invention
System, those skilled in the art are according to the basic thought of the present invention, and various modifications may be made or improves, but without departing from this
The basic thought of invention, within the scope of the present invention.
Embodiment 1, a kind of gel pad pasting containing growth factor
Gel pad pasting described in the embodiment of the present invention 1 is made up of the hydrogel of base material and coating on the substrate, described
Hydrogel is made up of the component of following mass percent：High molecular weight hydrophilic gel-type vehicle 7%, rhEGF0.08%, glycerine 20%,
Hyaluronic acid 0.03%, allantoin 0.02%, Tween-80 0.12%, aluminium chloride 1%, tartaric acid 0.55%, EDTA-2Na
1%th, plants essential oil 0.2% and deionized water 70%, the gel-type vehicle is by sodium carboxymethylcellulose and Sodium Polyacrylate
By 1:2 weight presses 1 than composition, the plants essential oil by tea oil, lavender oil, rose oil and jasmin oil:1:1:1
Weight is than composition.
Preparation method：
A) sodium carboxymethylcellulose and Sodium Polyacrylate are fully soaked with glycerine, aluminium chloride, tartaric acid, plant is added
Essential oil, Tween-80, stir 20min；
B deionized water and EDTA-2Na) are continuously added, is stirred, rhEGF, hyaluronic acid, allantoin is added,
6min is stirred under vacuum, the gel-type vehicle of flow-like is made；
C) gel-type vehicle of above-mentioned flow-like is coated with by hydrogel adhesive film machine, cut, is produced.
Embodiment 2, a kind of gel pad pasting containing growth factor
Gel pad pasting described in the embodiment of the present invention 2 is made up of the hydrogel of base material and coating on the substrate, described
Hydrogel is made up of the component of following mass percent：High molecular weight hydrophilic gel-type vehicle 6%, growth factor 0.05%, glycerine
30%th, hyaluronic acid 0.01%, allantoin 0.01%, Tween-80 0.1%, calcium sulfate 0.5%, citric acid 0.2%, EDTA-
2Na 0.05%, plants essential oil 0.4%, methyl p-hydroxybenzoate 0.05%, essence 0.02% and deionized water 60%,
The gel-type vehicle presses 1 by sodium carboxymethylcellulose and Sodium Polyacrylate:5 weight than composition, the growth factor by
RhEGF and rh-bFGF presses 1:1 weight is than composition, and the plants essential oil is by tea oil, lavender oil, rose oil and jasmine
Caul-fat presses 1:1:1:1 weight is than composition.
Preparation method：The step B) also include adding methyl p-hydroxybenzoate and essence, remaining step is with reference to real
Apply example 1.
Embodiment 3, a kind of gel pad pasting containing growth factor
Gel pad pasting described in the embodiment of the present invention 3 is made up of the hydrogel of base material and coating on the substrate, described
Hydrogel is made up of the component of following mass percent：High molecular weight hydrophilic gel-type vehicle 6%, growth factor 0.06%, glycerine
26%th, hyaluronic acid 0.03%, allantoin 0.03%, Tween-80 0.1%, calcium sulfate 0.8%, citric acid 0.8%, EDTA-
2Na 0.1%, plants essential oil 1%, methyl p-hydroxybenzoate 0.05%, essence 0.03% and deionized water 65%, it is described
Gel-type vehicle presses 1 by sodium carboxymethylcellulose and Sodium Polyacrylate:3 weight than composition, the growth factor by rhEGF and
Rh-bFGF presses 1:1 weight presses 1 than composition, the plants essential oil by tea oil, lavender oil, rose oil and jasmin oil:
1:1:1 weight is than composition.
Preparation method reference implementation example 1.
Comparative example 1, a kind of gel pad pasting containing growth factor
Gel pad pasting described in comparative example 1 of the present invention is made up of the hydrogel of base material and coating on the substrate, described
Hydrogel is made up of the component of following mass percent：High molecular weight hydrophilic gel-type vehicle 6%, growth factor 0.06%, glycerine
26%th, hyaluronic acid 0.03%, allantoin 0.03%, Tween-80 0.1%, calcium hydroxide 0.8%, citric acid 0.8%,
EDTA-2Na 0.1%, plants essential oil 1%, methyl p-hydroxybenzoate 0.05%, essence 0.03% and deionized water 65%,
The high molecular weight hydrophilic gel-type vehicle presses 1 by sodium carboxymethylcellulose and Sodium Polyacrylate:3 weight is than composition, the life
The long factor presses 1 by rhEGF and rh-bFGF:1 weight is than composition, and the plants essential oil is by tea oil, lavender oil, rose
Oil and jasmin oil press 1:1:1:1 weight is than composition.
Preparation method reference implementation example 3.
The difference of comparative example 1 and embodiment 3 is, calcium sulfate is replaced with into calcium hydroxide.
Performance test
Example 1~3 and the gained gel pad pasting of comparative example 1, according to People's Republic of China's light industry standard
" QB-T2872-2007 pad pastings " is tested its sense organ, physics and chemistry and sanitary index, and test result is as shown in table 1 below.
The test result of table 1
As seen from Table 1, gel pad pasting made from the embodiment of the present invention 1~3 and comparative example 1 sense organ, physics and chemistry and
Meet the requirement of People's Republic of China's light industry standard in terms of sanitary index.
Different sodium carboxymethylcelluloses and Sodium Polyacrylate are with the influence for comparing gel rubber plaster film performance
On the basis of embodiment 3,4 kinds of different sodium carboxymethylcelluloses and Sodium Polyacrylate proportioning (such as table 2) are set,
1. -4. group is respectively labeled as, the close sense, moisturizing sense and salubrious sense when using above-mentioned 4 groups of gel pad pastings are tested, and are surveyed
Test result such as table 2.
Method of testing：The state that above-mentioned 4 groups of gels pad pasting above body is erected is attached at 40 female test persons' respectively
On the face, the close sense that uses when being stood 20 minutes with following 5 Phase Evaluations, and skin state after being peelled off after 20 minutes
Moisturizing sense and salubrious sense, full marks are 50 points, take its average value, as a result as shown in table 2 below.
Close sense is evaluated：
50 points (being close to skin completely, do not misplace)；40 points (being close to skin substantially, almost do not misplace)；30 points
(there is the position for not being close to skin, somewhat have dislocation)；20 points (being difficult to be close to skin, misplace many)；10 points (dislocation is big
And slide).
Moisturizing sense is evaluated：
50 points (feeling the notable moisturizing of skin)；40 points (feeling skin moisturizing)；30 points (feeling skin somewhat moisturizing)；20 points
(feeling skin almost without moisturizing)；10 points (imperceptible effect).
Salubrious sense is evaluated：
50 points (feeling that skin is significantly salubrious)；40 points (feeling that skin is salubrious)；30 points (feeling that skin is somewhat salubrious)；20 points
(skin feel is less than salubrious)；10 points (imperceptible effect).
The test result of table 2
| Group | Sodium carboxymethylcellulose | Sodium Polyacrylate | Close sense (is divided) | Moisturizing sense (divides) | Salubrious sense (dividing) |
| ① | 1 | 3 | 44 | 48 | 47 |
| ② | 1 | 6 | 42 | 46 | 48 |
| ③ | 1 | 0.05 | 36 | 42 | 46 |
| ④ | 2 | 3 | 48 | 40 | 36 |
As shown in Table 2, the close sense of pad pasting increases with the increase of sodium carboxymethylcellulose consumption, but its is salubrious
Sense and moisturizing sense are significantly reduced；As the salubrious sense of the increase gel pad pasting of the consumption of Sodium Polyacrylate increases, but patch
The close sense of film and moisturizing sense first increase the trend reduced afterwards, and in summary analysis can be drawn, when sodium carboxymethylcellulose and
Sodium Polyacrylate presses 1:When 3 weight forms gel than compounding, its close sense, moisturizing sense and salubrious sense can obtain most people
Accreditation.
The using effect of inventive gel pad pasting
Trial target：Gel pad pasting, control group Yi Si snail elite hydrogel adhesive films prepared by embodiment 1~3, comparative example 1
(South Korea Its skin, 5 * 25g).
Tested crowd：
Sex number：Female, 100 people.
Age：Between 22~50 years old.
Health status：Subjects skin's health, no skin disease allergies meet subject's aspiration inclusion criteria.
Packet：It is divided into 5 groups, every group of 20 people.
Method of testing：Example 1~3, the gel pad pasting of comparative example 1 and control group facial mask are used respectively.Application method：Subject
Face first is cleaned with clear water using preceding, wrapping paper is opened, removes gel pad pasting, gel face is attached on the face, smoothed, stand 20
Minute, three-times-weekly, continue 1 one months, close sense when being used with following 5 Phase Evaluation pad pastings, and shelled after 20 minutes
The moisturizing sense of skin state after going, salubrious sense and whitening effect, full marks are 50 points, and are recorded in detail.
Whitening effect is evaluated：50 points (whitening effect is notable)；40 (having whitening effect)；30 (feeling skin somewhat whitening)；
20 (feeling skin almost without whitening effect)；10 (imperceptible effects).
Close sense, moisturizing sense and the effect assessment clearly felt refer to above-mentioned experiment.
Test assessment result as follows：
(one month) the on probation feedback conclusive table of table 3
Salubrious sense as seen from Table 3, after the gel pad pasting of the embodiment of the present invention 1~3 close sense when in use, use,
It is far superior to control group in terms of moisturizing sense and whitening effect, particularly in terms of close sense and salubrious sense, control group is notable
Less than 1~3 group of the embodiment of the present invention；Wherein 3 groups of the embodiment of the present invention all achieves excellent effect at above-mentioned 4 aspects, therefore
Embodiment 3 is preferred embodiment.
Claims (2)
1. a kind of gel pad pasting containing growth factor, it is characterised in that the pad pasting is by base material and is coated on the base material
On hydrogel composition, the hydrogel is made up of the component of following mass percent：High molecular weight hydrophilic gel-type vehicle 6%, life
The long factor 0.06%, glycerine 26%, hyaluronic acid 0.03%, allantoin 0.03%, Tween-80 0.1%, calcium sulfate 0.8%,
Citric acid 0.8%, EDTA-2Na0.1%, plants essential oil 1%, methyl p-hydroxybenzoate 0.05%, essence 0.03%, deionization
Water 65%, the high molecular weight hydrophilic gel-type vehicle presses 1 by sodium carboxymethylcellulose and Sodium Polyacrylate:3 weight is than composition, institute
Growth factor is stated by rhEGF and rh-bFGF by 1:1 weight is than composition, and the plants essential oil is by tea oil, lavender oil, rose
Rare caul-fat and jasmin oil press 1:1:1:1 weight is than composition.
2. the preparation method of the gel pad pasting as claimed in claim 1 containing growth factor, it is characterised in that including following step
Suddenly：
A) high molecular weight hydrophilic gel-type vehicle is fully soaked with 26% glycerine, 0.8% calcium sulfate, 0.8% citric acid, 1% plant is added
Essential oil, 0.1% Tween-80, stir 20min；
B deionized water 65% and EDTA-2Na0.1%) are continuously added, is stirred, 0.06% growth factor, 0.03% is added
Hyaluronic acid, 0.03% allantoin, 0.05% methyl p-hydroxybenzoate, 0.03% essence, are stirred under vacuum 6min, fluid are made
The gel-type vehicle of shape；
C) gel-type vehicle of above-mentioned flow-like is coated with by hydrogel adhesive film machine, cut, is produced.
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| CN107184439A (en) * | 2017-06-15 | 2017-09-22 | 天津郁美净集团有限公司 | A kind of skin care compositions with crease-resistant effect and preparation method and application |
| CN107349129A (en) * | 2017-07-03 | 2017-11-17 | 李剑峰 | Facial mask liquid and its preparation method and application |
| CN107519034A (en) * | 2017-08-17 | 2017-12-29 | 成都新柯力化工科技有限公司 | A kind of skin deep layer of the bioactie agent containing chelating repairs liquid and preparation method thereof |
| CN111973535B (en) * | 2020-09-10 | 2023-08-08 | 李时珍国灸集团蕲艾产业(蕲春)有限公司 | Mugwort leaf washing-free disinfection gel and preparation method thereof |
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| CN103394116B (en) * | 2013-08-21 | 2015-03-11 | 彭长生 | Hydrogel dressing capable of promoting wound healing and preparation method thereof |
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Address after: 442000 No. 698 Bingbing Road, Yunyang Economic Development Zone, Shiyan City, Hubei Province Patentee after: Hubei Bingbing Pharmaceutical Industry (Group) Co., Ltd. Address before: Longyang Road 430056 Hubei city of Wuhan province Kangda street Hanyang District No. 5 Patentee before: Bingbing Pharmaceutical Co., Ltd., Wuhan |