CN106692403A - Antipruritic ointment and preparation method thereof - Google Patents
Antipruritic ointment and preparation method thereof Download PDFInfo
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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Abstract
The invention discloses an antipruritic ointment and a preparation method thereof. The antipruritic ointment comprises effective components and a matrix, and is characterized in that the effective components comprise the following components in part by weight: 1-5 parts of sublimed sulfur, 1-5 parts of paeonol, 0.5-3 parts of dexamethasone acetate, 1-5 parts of camphor, 0.1-0.5 part of chitosan, 3-8 parts of radix sophorae flavescentis extract, 3-8 parts of lithospermum extract, 0.5-5 parts of eucalyptus oil, 3-8 parts of Phellodendron extract, 1-5 parts of borneol and 1-5 parts of peppermint oil. The preparation method comprises the preparation of an aqueous phase, the preparation of an oil phase and the preparation of a finished product. The antipruritic ointment is delicate and white, has a fresh smell, has the effect of relieving itching, sterilizing and resisting inflammation, and can control and relieve most of pruritus and skin lesions. The antipruritic ointment has the advantages of rapid action and no toxic and side effects.
Description
Technical field
The present invention relates to medicine.
Background technology
The activity of people inevitably contacts various environment, and it is exactly skin to stand in the breach affected.Due to by height
The influence of the environmental factors such as temperature, humidity, and continue nervous, excited and fatigue etc., can trigger skin disease,
Various dermatopathies such as eczema, furuncle, tinea pedis, prickly heat are relatively common.Itch is one of many dermopathic performances, serious
The routine work life that itch can give people brings very big inconvenience.And skin disease easily recurs, it is difficult to effect a radical cure.Therefore exploitation one
The medicine that can control and alleviate such disease of skin is planted with very huge meaning.
The content of the invention
Regarding to the issue above, the present invention provides a kind of antipruritic ointment and preparation method thereof.Antipruritic ointment of the invention include effectively into
Divide and matrix, it is characterised in that the active ingredient is made up of the component of following weight portion：1~5 part of sublimed sulfur, Paeonol 1~5
Part, 0.5~3 part of dexamethasone acetate, 1~5 part of camphor, 0.1~0.5 part of shitosan, 3~8 parts of shrubby sophora extract, Asian puccoon are extracted
3~8 parts of thing, 0.5~5 part of eucalyptus oil, 3~8 parts of phellodendron extract, 1~5 part of borneol, 1~5 part of peppermint oil.
Further, the active ingredient is made up of the component of following weight portion：2~4 parts of sublimed sulfur, 2~4 parts of Paeonol, vinegar
0.8~2 part of sour dexamethasone, 2~4 parts of camphor, 0.2~0.4 part of shitosan, 5~7 parts of shrubby sophora extract, Radix Arnebiae extract 5~7
Part, 0.8~3 part of eucalyptus oil, 5~7 parts of phellodendron extract, 2~4 parts of borneol, 2~4 parts of peppermint oil.
Further, it is characterised in that the active ingredient is made up of the component of following weight portion：3 parts of sublimed sulfur, Paeonol 3
Part, 1 part of dexamethasone acetate, 3 parts of camphor, 0.3 part of shitosan, 6 parts of shrubby sophora extract, 6 parts of Radix Arnebiae extract, eucalyptus
2 parts of leaf oil, phellodendron extract 6,3 parts of borneol, 3 parts of peppermint oil.
Specifically, the shitosan is shitosan of the deacetylation more than 85%.
Further, the matrix is made up of the component of following weight portion：13~18 parts of albolene, glyceryl laurate ester 5~13
Part, 20~30 parts of cetanol, 3~10 parts of lauryl sodium sulfate, 13~18 parts of beeswax, 10~15 parts of glycerine, preservative 0.1~0.5
Part, 50~80 parts of deionized water.
Further, the matrix is made up of the component of following weight portion：14~17 parts of albolene, glyceryl laurate ester 8~10
Part, 23~28 parts of cetanol, 5~8 parts of lauryl sodium sulfate, 14~16 parts of beeswax, 12~14 parts of glycerine, preservative 0.2~0.4
Part, 60~73 parts of deionized water.
Specifically, the preservative is one or two the combination in Phenoxyethanol, methyl hydroxybenzoate.
A kind of preparation method of antipruritic ointment of the invention, it is characterised in that comprise the following steps：
(1) preparation of water phase：By the formula ratio, take suitable quantity of water and dissolve shitosan and lauryl sodium sulfate, and and kuh-seng
Extract, phellodendron extract, Radix Arnebiae extract and excess water are well mixed, and are heated to 60~80 DEG C；
(2) preparation of oil phases：By Paeonol, dexamethasone acetate, camphor, eucalyptus oil, borneol, peppermint oil, albolene,
Glyceryl laurate ester, cetanol, beeswax, glycerine are well mixed with preservative, and are heated to 60~80 DEG C；
(3) preparation of finished products：Under insulation, by the sublimed sulfur of water phase, oil phase and formula ratio obtained in step (2) obtained in step (1)
It is placed in ointment, it is homogenized under 3000r/min stirrings；Room temperature is gradually cooling under 20r/min stirrings, discharge to obtain finished product.
Specifically, the preparation method of the shrubby sophora extract is：Dry grinding is shone after kuh-seng is cleaned, Lightyellow Sophora Root is added 5 times
In the ethanol solution of the 50% of weight, 20~30min of ultrasonic extraction is extracted 2 times altogether, merges extract solution, is concentrated under reduced pressure into 60 DEG C
When relative density be 1.1~1.3 concentrate, obtain final product.
Specifically, the preparation method of the Radix Arnebiae extract is：Dry grinding is shone after Asian puccoon is cleaned, Arnebia Root is added 5 times
In the ethanol solution of the 50% of weight, 20~30min of ultrasonic extraction is extracted 2 times altogether, merges extract solution, is concentrated under reduced pressure into 60 DEG C
When relative density be 1.1~1.3 concentrate, obtain final product.
Specifically, the preparation method of the phellodendron extract is：Dry grinding is shone after golden cypress is cleaned, phellodendron powder is added 5 times
In the ethanol solution of the 50% of weight, 20~30min of ultrasonic extraction is extracted 2 times altogether, merges extract solution, is concentrated under reduced pressure into 60 DEG C
When relative density be 1.1~1.3 concentrate, obtain final product.
Shitosan has preferable antibacterial activity, can suppress the growth and breeding of some fungies, bacterium and virus.Think that it may
Mechanism have three：One is the mobility and permeability for changing pathogen cell membrane；Two is the duplication and transcription for disturbing DNA；Three
It is blocking pathogen metabolism.Shitosan has functions that good moisture absorption, moisturizing, can form a thin layer of in skin surface
Diaphragm, slows down and also protect skin to resist the stimulation in the external world while moisture of skin evaporates.
Eucalyptus oil is a kind of colourless to slightly yellow oily liquids, in the materials such as eucalyptus oil, cajaput oils, camphorated oil, laurel
Extract, in peculiar refrigerant spine folium eucalypti fragrance and band a few minutes camphor smell, with a little medicine gas, with certain bactericidal action.
Kuh-seng bitter, it is cold in nature.The thoughts of returning home, liver, stomach, large intestine, bladder warp.With heat-clearing and damp-drying drug, desinsection, the effect of diuresis.
For hot dysentery, have blood in stool, jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, mange leprosy, outward
Control trichomonas vaginitis.
Golden cypress bitter, it is cold in nature, return kidney, bladder warp.There are heat-clearing and damp-drying drug, purging intense heat, except steaming, effect of detoxification sore treatment.For damp and hot
Rush down dysentery, jaundice urine is red, under band pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis impotence is knitted, hectic fever due to yin labor heat, sore swollen toxin, eczema wet sore.
Asian puccoon is sweet, salty, cold in nature, being capable of cool blood, promoting blood circulation, promoting eruption of detoxifying.For blood-heat and toxin exuberance, atropurpureus macula, measles is not
Thoroughly, sore, eczema, scald etc..
Antipruritic ointment of the invention is pure white in exquisiteness, and smell is pure and fresh, it is easy to received by most people.Natural plant extracts phase
Mutually act synergistically, and be equipped with gentle ointment bases, quality is gently nonirritant.With itch-stopping bactericidal and antiphlogistic effects, can
Control and the most of itch phenomenon of alleviation and cutaneous lesions, work rapid, have no toxic side effect, and symptom does not rebound after being especially discontinued,
Without dependence phenomenon.
In order to more fully understand and implement, the following detailed description of the present invention.
Specific embodiment
Prepare embodiment
The preparation method of antipruritic ointment of the invention is as follows：
(1) preparation of shrubby sophora extracts：Dry grinding is shone after kuh-seng is cleaned, Lightyellow Sophora Root is added 5 times the 50% of weight of second
In alcoholic solution, 20~30min of ultrasonic extraction is extracted 2 times altogether, merges extract solution, and relative density is when being concentrated under reduced pressure into 60 DEG C
1.1~1.3 concentrate, obtains final product.
(2) preparation of Radix Arnebiae extracts：Dry grinding is shone after Asian puccoon is cleaned, Arnebia Root is added 5 times the 50% of weight of second
In alcoholic solution, 20~30min of ultrasonic extraction is extracted 2 times altogether, merges extract solution, and relative density is when being concentrated under reduced pressure into 60 DEG C
1.1~1.3 concentrate, obtains final product.
(3) preparation of phellodendron extracts：Dry grinding is shone after golden cypress is cleaned, phellodendron powder is added 5 times the 50% of weight of ethanol
In solution, 20~30min of ultrasonic extraction is extracted 2 times altogether, merges extract solution, and relative density is 1.1~1.3 when being concentrated under reduced pressure into 60 DEG C
Concentrate, obtain final product.
(4) preparation of water phase：By the formula ratio of table 1, shitosan and dodecyl sulphur of the suitable quantity of water by deacetylation more than 85% are taken
Sour sodium dissolving, and be well mixed with step (1)~shrubby sophora extract, phellodendron extract, Radix Arnebiae extract and excess water obtained in (3),
And it is heated to 60~80 DEG C；
(5) preparation of oil phases：By Paeonol, dexamethasone acetate, camphor, eucalyptus oil, borneol, peppermint oil, albolene,
Glyceryl laurate ester, cetanol, beeswax, glycerine are well mixed with preservative, and are heated to 60~80 DEG C；
(6) preparation of finished products：Under insulation, by the sublimed sulfur of water phase, oil phase and formula ratio obtained in step (5) obtained in step (4)
It is placed in ointment, it is homogenized under 3000r/min stirrings；Room temperature is gradually cooling under 20r/min stirrings, discharge to obtain finished product.
<The each component of table 1 is in parts by weight>
Antibacterial effect embodiment
According to GB 15979-2002《Disposable Sanitary Accessory sanitary standard》Appendix C determines the embodiment of the present invention 1~5 and makes
The antibacterial effect of standby antipruritic ointment.
Test organisms：Bacterium：Staphylococcus aureus (ATCC 6538), Escherichia coli (ATCC 25922)；
Saccharomycete：Candida albicans (ATCC 10231).
It is prepared by bacterium solution:The nutrient agar inclined-plane fresh cultured 18~24h of thing in the generation of bacterial strain the 3rd~14 is taken, 5ml 0.03mol/L are used
Phosphate buffer (hereinafter referred to as PBS) washes lower lawn, bacterium is diluted to required concentration with above-mentioned PBS after suspending uniformly.
Operating procedure：
Test organisms 24h slant cultures are washed down with PBS, bacteria suspension is made, it is desirable to concentration be：With 100 μ l drops in control
On print, bacterial count recovered is 1 × 104~9 × 104Cfu/ pieces.
Take by coupons (2.0cm × 3.0cm) and each 4 of print of control, be divided into 4 groups and be placed in 4 sterilizing plates.The control
Print and sample homogeneous material, equal size, but without anti-biotic material, and sterilized treatment.
Take above-mentioned bacteria suspension and be added dropwise 100 μ l in coupons and control print at each respectively, even spread starts timing, makees
With 2min, print is thrown into people respectively with aseptic tweezer and contains 5m1, in the test tube of corresponding nertralizer, fully mixed, make appropriate dilution,
Then wherein 2-3 dilution factor is taken, 0.5ml is drawn respectively, be placed in two plates, with cool to 40-45' DEG C of nutrient agar culture
Base (bacterium) or sabouraud's agar (saccharomycete) 15m1 are poured into, and rotate plate, make its full and uniform, are turned over after agar solidification
Turn flat board, 35 DEG C of scholars, 2 DEG C of cultures 48h (bacterium) or 72h (saccharomycete), make viable bacteria colony counting.Experiment is repeated 3 times, as the following formula
Calculate sterilizing rate：X=(A-B)/A × 100 part
In formula：X--- sterilizing rates, part；
A--- control sample average colony numbers；
The tested sample average clump counts of B---.
Evaluation criterion：Sterilizing rate >=90 part, product has bactericidal action.Result such as table 2 below：
<The sterilizing rate of table 2, activity is 1:1>
Antiphlogistic effects embodiment
Trial target：The embodiment of the present invention 1~5 and commercially available Compound Dexamethasone Acetate.
Experimental technique：One-level ICR mouse 80, body weight 20-22g, male and female half and half are divided into 1~5 group of the embodiment of the present invention (1.
0g/kg), positive controls：Compound Dexamethasone Acetate (3.0g/kg), simple Ointment group, every group of 12 mouse.Experimental day, by each group dosage
In animal auris dextra (the positive and negative both sides of auricle) coating；60min after medication, medicine is cleaned with dry cotton ball, in auris dextra (the positive and negative both sides of auricle)
Drop coating paraxylene, 30ul/ only, while coating once, after 20min takes off neck execution animal again, cuts two ears, uses diameter 0.8cm
Two ears are broken into disk by card punch, are weighed, and auris dextra subtracts left ear weight difference for swelling, the difference between comparative drug group and control group,
And obtain inhibiting rate.The results are shown in Table 3.
<The paraxylene of table 3 causes the influence of the scorching card of Mice Auricle>
* for commercially available product is compared, p ＜ 0.05.
Antipruritic effect embodiment
Trial target：The embodiment of the present invention 1~5 and commercially available Compound Dexamethasone Acetate.
Cavy is divided into the embodiment of the present invention 1~5 group of (1.0g/kg), positive controls dermatitis by cavy 80,250~300g of body weight
Flat ointment (3.0g/kg), and simple Ointment group.24hr before experiment, to instep shaving behind each group cavy right side, by this group of dosage in dynamic
Behind the thing right side instep shaving coating once, coating 1 time.On the experiment same day, abraded at right metapedes shaving with coarse sandpaper, abrasion area
It is 1cm2, only, hereafter often local coating 1 time again start in the histamine phosphate 0.05ml/ of surface of a wound Chu Di 0.01% after 10min
Every 3min successively with 0.02%, 0.03%, 0.04%... progressive concentration coatings, 0.05ml/ is every time only.Until cavy is turned one's head
It is itch-threshold to add histamine phosphate's total amount (μ g) given during right metapedes, records and compare the itch-threshold of each group.The results are shown in Table 4.
<The histamine phosphate of table 4 causes the influence that cavy itches enough>
Irritation test embodiment
Reference literature method is tested.
Tested material：Prepare the gained sample of embodiment 1~5 obtained in embodiment
Subject：Totally 36 people, men and women half and half, 20~30 years old age, meets subject's aspiration inclusion criteria.
Test method：Tested material is put into spot examination device, consumption is 0.023g.Control wells are blank (not putting any material).
The back or forearm song side of subject will be pasted on added with the spot of the tested material examination non-stimulated adhesive tape of device, be gently pressed with palm and is allowed to uniform
Be pasted on skin, continue 3min.30min after removal tested material spot examination device, dermoreaction is observed after impression disappears.Such as
Result is feminine gender, is observed again once respectively in 24h after patch test and 48h.By table 5 (skin adverse reaction grade scale table)
Record reaction result.
<The skin adverse reaction grade scale table of table 5>
Result of the test is shown in Table 6：
<Table 6 removes assessment result after tested material>
The result that 24h and 48h are observed again respectively after patch test is with table 5.Result above shows, antipruritic ointment pair of the invention
The nonirritant effect of human body skin.
The invention is not limited in above-mentioned implementation method, if not departing from spirit of the invention to various changes of the invention or deformation
And scope, if these are changed and within the scope of deformation belongs to claim of the invention and equivalent technologies, then the present invention is also intended to
Comprising these changes and deformation.
Claims (9)
1. a kind of antipruritic ointment, including active ingredient and matrix, it is characterised in that the active ingredient by following weight portion component group
Into：1~5 part of sublimed sulfur, 1~5 part of Paeonol, 0.5~3 part of dexamethasone acetate, 1~5 part of camphor, shitosan 0.1~0.5
Part, 3~8 parts of shrubby sophora extract, 3~8 parts of Radix Arnebiae extract, 0.5~5 part of eucalyptus oil, 3~8 parts of phellodendron extract, ice
1~5 part of piece, 1~5 part of peppermint oil.
2. antipruritic ointment according to claim 1, it is characterised in that the active ingredient is made up of the component of following weight portion：
2~4 parts of sublimed sulfur, 2~4 parts of Paeonol, 0.8~2 part of dexamethasone acetate, 2~4 parts of camphor, 0.2~0.4 part of shitosan,
5~7 parts of shrubby sophora extract, 5~7 parts of Radix Arnebiae extract, 0.8~3 part of eucalyptus oil, 5~7 parts of phellodendron extract, borneol 2~4
Part, 2~4 parts of peppermint oil.
3. antipruritic ointment according to claim 2, it is characterised in that the active ingredient is made up of the component of following weight portion：
3 parts of sublimed sulfur, 3 parts of Paeonol, 1 part of dexamethasone acetate, 3 parts of camphor, 0.3 part of shitosan, shrubby sophora extract 6
Part, 6 parts of Radix Arnebiae extract, 2 parts of eucalyptus oil, phellodendron extract 6,3 parts of borneol, 3 parts of peppermint oil.
4. the antipruritic ointment according to claims 1 to 3 any one, it is characterised in that：The shitosan is more than for deacetylation
85% shitosan.
5. the antipruritic ointment according to claims 1 to 3 any one, it is characterised in that the matrix by following weight portion component
Composition：13~18 parts of albolene, 5~13 parts of glyceryl laurate ester, 20~30 parts of cetanol, lauryl sodium sulfate 3~10
Part, 13~18 parts of beeswax, 10~15 parts of glycerine, 0.1~0.5 part of preservative, 50~80 parts of deionized water.
6. the antipruritic ointment according to claims 1 to 3 any one, it is characterised in that the matrix by following weight portion component
Composition：14~17 parts of albolene, 8~10 parts of glyceryl laurate ester, 23~28 parts of cetanol, lauryl sodium sulfate 5~8
Part, 14~16 parts of beeswax, 12~14 parts of glycerine, 0.2~0.4 part of preservative, 60~73 parts of deionized water.
7. the antipruritic ointment according to claim 5~6 any one, it is characterised in that：The preservative is Phenoxyethanol, hydroxyl
One or two combination in benzene methyl.
8. a kind of method for preparing the antipruritic ointment described in claim 5~6 any one, it is characterised in that comprise the following steps：
(1) preparation of water phase：By the formula ratio, take suitable quantity of water and dissolve shitosan and lauryl sodium sulfate, and and kuh-seng
Extract, phellodendron extract, Radix Arnebiae extract and excess water are well mixed, and are heated to 60~80 DEG C；
(2) preparation of oil phases：By Paeonol, dexamethasone acetate, camphor, eucalyptus oil, borneol, peppermint oil, albolene,
Glyceryl laurate ester, cetanol, beeswax, glycerine are well mixed with preservative, and are heated to 60~80 DEG C；
(3) preparation of finished products：Under insulation, by the sublimed sulfur of water phase, oil phase and formula ratio obtained in step (2) obtained in step (1)
It is placed in ointment, it is homogenized under 3000r/min stirrings；Room temperature is gradually cooling under 20r/min stirrings, is gone out
Expect to obtain finished product.
9. the preparation method of antipruritic ointment according to claim 8, it is characterised in that：
The preparation method of the shrubby sophora extract is：Dry grinding is shone after kuh-seng is cleaned, by Lightyellow Sophora Root 5 times of weight of addition
In 50% ethanol solution, 20~30min of ultrasonic extraction is extracted 2 times altogether, merges extract solution, when being concentrated under reduced pressure into 60 DEG C
Relative density is 1.1~1.3 concentrate, is obtained final product；
The preparation method of the Radix Arnebiae extract is：Dry grinding is shone after Asian puccoon is cleaned, by Arnebia Root 5 times of weight of addition
In 50% ethanol solution, 20~30min of ultrasonic extraction is extracted 2 times altogether, merges extract solution, when being concentrated under reduced pressure into 60 DEG C
Relative density is 1.1~1.3 concentrate, is obtained final product；
The preparation method of the phellodendron extract is：Dry grinding is shone after golden cypress is cleaned, by phellodendron powder 5 times of weight of addition
In 50% ethanol solution, 20~30min of ultrasonic extraction is extracted 2 times altogether, merges extract solution, when being concentrated under reduced pressure into 60 DEG C
Relative density is 1.1~1.3 concentrate, is obtained final product.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510782720.2A CN106692403A (en) | 2015-11-13 | 2015-11-13 | Antipruritic ointment and preparation method thereof |
| PCT/CN2015/098907 WO2017080049A1 (en) | 2015-11-13 | 2015-12-25 | Antipruritic ointment and method for preparing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510782720.2A CN106692403A (en) | 2015-11-13 | 2015-11-13 | Antipruritic ointment and preparation method thereof |
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| CN106692403A true CN106692403A (en) | 2017-05-24 |
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| CN201510782720.2A Pending CN106692403A (en) | 2015-11-13 | 2015-11-13 | Antipruritic ointment and preparation method thereof |
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| Country | Link |
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| CN (1) | CN106692403A (en) |
| WO (1) | WO2017080049A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578287A (en) * | 2018-04-27 | 2018-09-28 | 广东名辰堂健康产业股份有限公司 | A kind of antipruritic cooling ointment and preparation method thereof |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111956691B (en) * | 2019-05-18 | 2023-03-14 | 云南伦扬科技有限公司 | Preparation method and application of lithospermum eucalyptol microemulsion gel |
| CN112870137A (en) * | 2021-01-22 | 2021-06-01 | 上海加新生物科技有限公司 | Composite raw material for female private care solution and preparation method thereof |
| CN116421635A (en) * | 2023-04-27 | 2023-07-14 | 小布悠(杭州)科技有限公司 | Low-irritation antipruritic ball formula and preparation method thereof |
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| CN101199787A (en) * | 2007-12-06 | 2008-06-18 | 朱锋 | Medicament compound for treating skin disease |
| CN102366437A (en) * | 2011-07-15 | 2012-03-07 | 吉林敖东集团大连药业股份有限公司 | Compound dexamethasone ointment and preparation method thereof |
| CN103565871A (en) * | 2012-08-08 | 2014-02-12 | 陕西盘龙药业集团股份有限公司 | Sterilizing and anti-itching traditional Chinese medicine composition and preparation method thereof |
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|---|---|---|---|---|
| CN1296084C (en) * | 2004-09-08 | 2007-01-24 | 郁增舜 | Externally applied medicine for treating chronic dermatopathy |
| CN103432584A (en) * | 2013-08-14 | 2013-12-11 | 金红叶纸业集团有限公司 | Cooling and itching relieving composition and paper towel employing same |
| CN104997918A (en) * | 2015-07-17 | 2015-10-28 | 柳培健 | Foot tinea treating traditional Chinese medicine composition |
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2015
- 2015-11-13 CN CN201510782720.2A patent/CN106692403A/en active Pending
- 2015-12-25 WO PCT/CN2015/098907 patent/WO2017080049A1/en active Application Filing
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| CN101199787A (en) * | 2007-12-06 | 2008-06-18 | 朱锋 | Medicament compound for treating skin disease |
| CN102366437A (en) * | 2011-07-15 | 2012-03-07 | 吉林敖东集团大连药业股份有限公司 | Compound dexamethasone ointment and preparation method thereof |
| CN103565871A (en) * | 2012-08-08 | 2014-02-12 | 陕西盘龙药业集团股份有限公司 | Sterilizing and anti-itching traditional Chinese medicine composition and preparation method thereof |
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| 熊芬等: "中西医结合治疗结节性痒疹临床观察", 《中国皮肤性病学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578287A (en) * | 2018-04-27 | 2018-09-28 | 广东名辰堂健康产业股份有限公司 | A kind of antipruritic cooling ointment and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| WO2017080049A1 (en) | 2017-05-18 |
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Application publication date: 20170524 |